Strain Name:

B6.129S4-Prkcetm1Msg/J

Stock Number:

004189

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Availability:

Cryopreserved - Ready for recovery

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Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
 
Donating Investigator Robert Messing,   University of California, San Francisco

Description
Mice that are homozygous for the Prkcetm1Msg targeted mutation are viable, normal in size and do not display any gross physical or behavioral abnormalities. Homozygous females produce small litters (0-2 pups). Protein kinase C, epsilon protein was not immunodetectable in dorsal root ganglia or in the central nervous system of mutant mice. Homozygous mutant mice exhibit reduced anxiety, reduced alcohol consumption and reduced responses to nociceptive stimuli. The mice are also supersensitive to acute behavioral effects of allosteric Gamma aminobutyrate (GABA) type A receptor activating drugs. This strain represents a model that may be useful in studies of pharmacological agents for the treatment of alcoholism, anxiety and pain.

Development
A targeting vector containing neomycin resistance and herpes simplex virus thymidine kinase genes was used to disrupt a 1.2 Kb region of the Prkce gene, including the exon encoding the translation initiation codon. The construct was electroporated into 129S4/SvJae derived RF8 embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6 blastocysts. The resulting chimeric animals were backcrossed to C57BL/6J mice.

Control Information

  Control
   Wild-type from the colony
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Phenotype

Phenotype Information

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Prkcetm1Msg related

Cancer Research
Genes Regulating Growth and Proliferation

Cell Biology Research
Genes Regulating Growth and Proliferation

Sensorineural Research
Nociception

Currently there is no phenotype information for this strain.

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Prkcetm1Msg
Allele Name targeted mutation 1, Robert Messing
Allele Type Targeted (Null/Knockout)
Common Name(s) PKC-epsilon-; PKCepsilon-;
Mutation Made By Robert Messing,   University of California, San Francisco
Strain of Origin129S4/SvJae
ES Cell Line NameRF8
ES Cell Line Strain129S4/SvJae
Gene Symbol and Name Prkce, protein kinase C, epsilon
Chromosome 17
Gene Common Name(s) 5830406C15Rik; PKCE; PKC[e]; PKCepsilon; Pkce; R75156; RIKEN cDNA 5830406C15 gene; expressed sequence R75156; nPKC-epsilon;
Molecular Note 1.2 kb of this gene including the translation initiation site was deleted via homologous recombination with a neo-derived targeting vector. Western blot indicated homozygous mutant animals did not express protein in dorsal root ganglion. [MGI Ref ID J:57887]

Genotyping

Genotyping Information

Genotyping Protocols

Prkcetm1Msg, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Khasar SG; Lin YH; Martin A; Dadgar J; McMahon T; Wang D; Hundle B; Aley KO; Isenberg W; McCarter G; Green PG; Hodge CW; Levine JD; Messing RO. 1999. A novel nociceptor signaling pathway revealed in protein kinase C epsilon mutant mice. Neuron 24(1):253-60. [PubMed: 10677042]  [MGI Ref ID J:57887]

Additional References

Jin ZQ; Zhou HZ; Zhu P; Honbo N; Mochly-Rosen D; Messing RO; Goetzl EJ; Karliner JS; Gray MO. 2002. Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild-type and PKC epsilon knockout mouse hearts. Am J Physiol Heart Circ Physiol 282(6):H1970-7. [PubMed: 12003800]  [MGI Ref ID J:77066]

Olive MF; Mehmert KK; Messing RO; Hodge CW. 2000. Reduced operant ethanol self-administration and in vivo mesolimbic dopamine responses to ethanol in PKCepsilon-deficient mice. Eur J Neurosci 12(11):4131-40. [PubMed: 11069609]  [MGI Ref ID J:89422]

Prkcetm1Msg related

Akoyev V; Das S; Jena S; Grauer L; Takemoto DJ. 2009. Hypoxia-regulated activity of PKCepsilon in the lens. Invest Ophthalmol Vis Sci 50(3):1271-82. [PubMed: 18997087]  [MGI Ref ID J:146679]

Bajo M; Cruz MT; Siggins GR; Messing R; Roberto M. 2008. Protein kinase C epsilon mediation of CRF- and ethanol-induced GABA release in central amygdala. Proc Natl Acad Sci U S A 105(24):8410-5. [PubMed: 18541912]  [MGI Ref ID J:137220]

Barnett M; Lin D; Akoyev V; Willard L; Takemoto D. 2008. Protein kinase C epsilon activates lens mitochondrial cytochrome c oxidase subunit IV during hypoxia. Exp Eye Res 86(2):226-34. [PubMed: 18070622]  [MGI Ref ID J:132507]

Bhavanasi D; Kim S; Goldfinger LE; Kunapuli SP. 2011. Protein kinase Cdelta mediates the activation of protein kinase D2 in platelets. Biochem Pharmacol 82(7):720-7. [PubMed: 21736870]  [MGI Ref ID J:176476]

Bynagari-Settipalli YS; Lakhani P; Jin J; Bhavaraju K; Rico MC; Kim S; Woulfe D; Kunapuli SP. 2012. Protein kinase C isoform epsilon negatively regulates ADP-induced calcium mobilization and thromboxane generation in platelets. Arterioscler Thromb Vasc Biol 32(5):1211-9. [PubMed: 22362759]  [MGI Ref ID J:196934]

Choi DS; Wang D; Dadgar J; Chang WS; Messing RO. 2002. Conditional rescue of protein kinase C epsilon regulates ethanol preference and hypnotic sensitivity in adult mice. J Neurosci 22(22):9905-11. [PubMed: 12427847]  [MGI Ref ID J:80186]

Choi DS; Wang D; Yu GQ; Zhu G; Kharazia VN; Paredes JP; Chang WS; Deitchman JK; Mucke L; Messing RO. 2006. PKCepsilon increases endothelin converting enzyme activity and reduces amyloid plaque pathology in transgenic mice. Proc Natl Acad Sci U S A 103(21):8215-20. [PubMed: 16698938]  [MGI Ref ID J:110206]

Ehre C; Zhu Y; Abdullah LH; Olsen J; Nakayama KI; Nakayama K; Messing RO; Davis CW. 2007. nPKCepsilon, a P2Y2-R downstream effector in regulated mucin secretion from airway goblet cells. Am J Physiol Cell Physiol 293(5):C1445-54. [PubMed: 17728398]  [MGI Ref ID J:145117]

Gray MO; Zhou HZ; Schafhalter-Zoppoth I; Zhu P; Mochly-Rosen D; Messing RO. 2004. Preservation of base-line hemodynamic function and loss of inducible cardioprotection in adult mice lacking protein kinase C epsilon. J Biol Chem 279(5):3596-604. [PubMed: 14600145]  [MGI Ref ID J:87583]

Hodge CW; Mehmert KK; Kelley SP; McMahon T; Haywood A; Olive MF; Wang D; Sanchez-Perez AM; Messing RO. 1999. Supersensitivity to allosteric GABA(A) receptor modulators and alcohol in mice lacking PKCepsilon. Nat Neurosci 2(11):997-1002. [PubMed: 10526339]  [MGI Ref ID J:58126]

Hodge CW; Raber J; McMahon T; Walter H; Sanchez-Perez AM; Olive MF; Mehmert K; Morrow AL; Messing RO. 2002. Decreased anxiety-like behavior, reduced stress hormones, and neurosteroid supersensitivity in mice lacking protein kinase Cepsilon. J Clin Invest 110(7):1003-10. [PubMed: 12370278]  [MGI Ref ID J:79806]

Jin ZQ; Zhou HZ; Zhu P; Honbo N; Mochly-Rosen D; Messing RO; Goetzl EJ; Karliner JS; Gray MO. 2002. Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild-type and PKC epsilon knockout mouse hearts. Am J Physiol Heart Circ Physiol 282(6):H1970-7. [PubMed: 12003800]  [MGI Ref ID J:77066]

Kaiser JP; Beier JI; Zhang J; David Hoetker J; von Montfort C; Guo L; Zheng Y; Monia BP; Bhatnagar A; Arteel GE. 2009. PKCepsilon plays a causal role in acute ethanol-induced steatosis. Arch Biochem Biophys 482(1-2):104-11. [PubMed: 19022218]  [MGI Ref ID J:146581]

Kitaura J; Eto K; Kinoshita T; Kawakami Y; Leitges M; Lowell CA; Kawakami T. 2005. Regulation of highly cytokinergic IgE-induced mast cell adhesion by Src, Syk, Tec, and protein kinase C family kinases. J Immunol 174(8):4495-504. [PubMed: 15814670]  [MGI Ref ID J:98164]

Lee AM; Messing RO. 2011. Protein kinase C epsilon modulates nicotine consumption and dopamine reward signals in the nucleus accumbens. Proc Natl Acad Sci U S A 108(38):16080-5. [PubMed: 21911393]  [MGI Ref ID J:176883]

Lesscher HM; McMahon T; Lasek AW; Chou WH; Connolly J; Kharazia V; Messing RO. 2008. Amygdala protein kinase C epsilon regulates corticotropin-releasing factor and anxiety-like behavior. Genes Brain Behav 7(3):323-33. [PubMed: 17908177]  [MGI Ref ID J:147475]

Lesscher HM; Wallace MJ; Zeng L; Wang V; Deitchman JK; McMahon T; Messing RO; Newton PM. 2009. Amygdala protein kinase C epsilon controls alcohol consumption. Genes Brain Behav 8(5):493-9. [PubMed: 19243450]  [MGI Ref ID J:151115]

Littler CM; Morris KG Jr; Fagan KA; McMurtry IF; Messing RO; Dempsey EC. 2003. Protein kinase C-epsilon-null mice have decreased hypoxic pulmonary vasoconstriction. Am J Physiol Heart Circ Physiol 284(4):H1321-31. [PubMed: 12505875]  [MGI Ref ID J:83035]

Littler CM; Wehling CA; Wick MJ; Fagan KA; Cool CD; Messing RO; Dempsey EC. 2005. Divergent contractile and structural responses of the murine PKC-epsilon null pulmonary circulation to chronic hypoxia. Am J Physiol Lung Cell Mol Physiol 289(6):L1083-93. [PubMed: 16085670]  [MGI Ref ID J:105000]

Liu QH; Zheng YM; Korde AS; Li XQ; Ma J; Takeshima H; Wang YX. 2009. Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells. Am J Respir Cell Mol Biol 40(6):663-71. [PubMed: 19011160]  [MGI Ref ID J:160862]

Nasser MW; Marjoram RJ; Brown SL; Richardson RM. 2005. Cross-desensitization among CXCR1, CXCR2, and CCR5: role of protein kinase C-epsilon1. J Immunol 174(11):6927-33. [PubMed: 15905535]  [MGI Ref ID J:99016]

Newton PM; Kim JA; McGeehan AJ; Paredes JP; Chu K; Wallace MJ; Roberts AJ; Hodge CW; Messing RO. 2007. Increased response to morphine in mice lacking protein kinase C epsilon. Genes Brain Behav 6(4):329-38. [PubMed: 16899053]  [MGI Ref ID J:137288]

Olive MF; Mehmert KK; Messing RO; Hodge CW. 2000. Reduced operant ethanol self-administration and in vivo mesolimbic dopamine responses to ethanol in PKCepsilon-deficient mice. Eur J Neurosci 12(11):4131-40. [PubMed: 11069609]  [MGI Ref ID J:89422]

Olive MF; Mehmert KK; Nannini MA; Camarini R; Messing RO; Hodge CW. 2001. Reduced ethanol withdrawal severity and altered withdrawal-induced c-fos expression in various brain regions of mice lacking protein kinase C-epsilon. Neuroscience 103(1):171-9. [PubMed: 11311798]  [MGI Ref ID J:125979]

Proctor WR; Poelchen W; Bowers BJ; Wehner JM; Messing RO; Dunwiddie TV. 2003. Ethanol differentially enhances hippocampal GABA A receptor-mediated responses in protein kinase C gamma (PKC gamma) and PKC epsilon null mice. J Pharmacol Exp Ther 305(1):264-70. [PubMed: 12649378]  [MGI Ref ID J:124740]

Qi ZH; Song M; Wallace MJ; Wang D; Newton PM; McMahon T; Chou WH; Zhang C; Shokat KM; Messing RO. 2007. Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits. J Biol Chem 282(45):33052-63. [PubMed: 17875639]  [MGI Ref ID J:126967]

Rathore R; Zheng YM; Li XQ; Wang QS; Liu QH; Ginnan R; Singer HA; Ho YS; Wang YX. 2006. Mitochondrial ROS-PKCepsilon signaling axis is uniquely involved in hypoxic increase in [Ca2+]i in pulmonary artery smooth muscle cells. Biochem Biophys Res Commun 351(3):784-90. [PubMed: 17087917]  [MGI Ref ID J:115267]

Rathore R; Zheng YM; Niu CF; Liu QH; Korde A; Ho YS; Wang YX. 2008. Hypoxia activates NADPH oxidase to increase [ROS]i and [Ca2+]i through the mitochondrial ROS-PKCepsilon signaling axis in pulmonary artery smooth muscle cells. Free Radic Biol Med 45(9):1223-31. [PubMed: 18638544]  [MGI Ref ID J:141206]

Wood TR; Chow RY; Hanes CM; Zhang X; Kashiwagi K; Shirai Y; Trebak M; Loegering DJ; Saito N; Lennartz MR. 2013. PKC-epsilon pseudosubstrate and catalytic activity are necessary for membrane delivery during IgG-mediated phagocytosis. J Leukoc Biol 94(1):109-22. [PubMed: 23670290]  [MGI Ref ID J:201847]

Wu DF; Chandra D; McMahon T; Wang D; Dadgar J; Kharazia VN; Liang YJ; Waxman SG; Dib-Hajj SD; Messing RO. 2012. PKCepsilon phosphorylation of the sodium channel NaV1.8 increases channel function and produces mechanical hyperalgesia in mice. J Clin Invest 122(4):1306-15. [PubMed: 22426212]  [MGI Ref ID J:184549]

Wyatt TA; Sisson JH; Allen-Gipson DS; McCaskill ML; Boten JA; Devasure JM; Bailey KL; Poole JA. 2012. Co-exposure to cigarette smoke and alcohol decreases airway epithelial cell cilia beating in a protein kinase cepsilon-dependent manner. Am J Pathol 181(2):431-40. [PubMed: 22677421]  [MGI Ref ID J:187004]

Yuan J; Lugea A; Zheng L; Gukovsky I; Edderkaoui M; Rozengurt E; Pandol SJ. 2008. Protein kinase D1 mediates NF-kappaB activation induced by cholecystokinin and cholinergic signaling in pancreatic acinar cells. Am J Physiol Gastrointest Liver Physiol 295(6):G1190-201. [PubMed: 18845574]  [MGI Ref ID J:143406]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryThis strain originated on a C57BL/6J X 129S4 background, and has been backcrossed for 10 generations on a C57BL/6J background. Coat color expected from breeding:Black

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2525.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $1650.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3283.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $2145.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   Wild-type from the colony
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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