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Description
Strain Information
Former Names STOCK Mttptm2Sgy Ldlrtm1Her Apobtm2Sgy TgN(Mx1-cre)1Cgn (Changed: 15-DEC-04 ) STOCK-Mttptm1SgyLdlrtm1SgyApobtm1SgyTgN(Mx-Cre)1Cgn (Changed: 15-DEC-04 ) STOCK-Mttptm2Sgy Ldlrtm1Her Apobtm2Sgy TgN(Mx1-Cre)1Cgn (Changed: 15-DEC-04 ) STOCK-Mttptm2Sgy Ldlrtm1Her Apobtm2Sgy TgN(Mx1-cre)1Cgn (Changed: 15-DEC-04 ) Type Mutant Strain; Targeted Mutation; Transgenic; Additional information on Genetically Engineered Mutant Mice. Species laboratory mouse Generation F?+4p (30-MAY-04) Donating Investigator Stephen Young, Gladstone Institutes UCSF Description
These mice are homozygous for four different induced mutations. The cumulative result of these mutations is a mouse model in which hypercholesterolemia can be reversed. By themselves, the combined presence of the Ldlrtm1Sgy and Apobtm1Sgy targeted alleles results in mice with a high susceptibility to atherosclerosis and total plasma cholesterol levels of approximately 300 mg/dl. A functional microsomal triglyceride transfer protein gene (Mttp) is essential for establishing a hypercholesterolemic condition. By flanking the Mttp gene with loxP sites and including a Mx1-Cre transgene, it is possible to reduce total plasma cholesterol levels from 300 mg/dl to 30 mg/dl upon induction of the Cre recombinase by administering interferon alpha, interferon beta, or synthetic double-stranded RNA. This unique model is useful in research related to the mechanisms and events of atherosclerotic reversal. Mice homozygous for the targeted alleles are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities.Development
The donating investigator combined existing induced alleles to create this model. See Stock No's 003902, 002077, 002877 and 003556.
Related Strains
Strains carrying Apobtm2Sgy allele
002879 B6;129-Apobtm2Sgy Apoetm1Unc/J 003000 B6;129S-Apobtm2Sgy Ldlrtm1Her/J 002877 B6;129S7-Apobtm2Sgy/J View Strains carrying Apobtm2Sgy (3 strains)
007070 AKR.129S7(B6)-Ldlrtm1Her/J 002246 B6.129-Apoetm1Unc Ldlrtm1Her/J 002207 B6.129S7-Ldlrtm1Her/J 006952 B6.Cg-Akt2tm1.1Mbb Ldlrtm1Her/J 006580 B6.Cg-Ins2Akita Ldlrtm1Her/J 006883 B6.Cg-Ldlrtm1Her Sod2tm1Leb/J 006877 B6.Cg-Ldlrtm1Her Tg(H2-K-AKR1B1)1Tj/J 006906 B6.Cg-Lepob Ldlrtm1Her/J 002245 B6;129-Apoetm1Unc Ldlrtm1Her/J 003000 B6;129S-Apobtm2Sgy Ldlrtm1Her/J 002465 B6;129S-Ldlrtm1Her Lrpap1tm1Her/J 002077 B6;129S7-Ldlrtm1Her/J 007068 D2.129S7(B6)-Ldlrtm1Her/J
003902 B6;129S-Mttptm2Sgy/J
006230 B6.Cg-Cebpatm1Dgt Tg(Mx1-cre)1Cgn/J 003556 B6.Cg-Tg(Mx1-cre)1Cgn/J 005673 C.Cg-Tg(Mx1-cre)1Cgn/J 002527 STOCK Tg(Mx1-cre)1Cgn/J
002053 B6.129P2-Apobtm1Unc/J 007682 B6.129X1-Apobtm1.1Zc/J 002878 B6;129-Apobtm1Sgy Apoetm1Unc/J 002876 B6;129S-Apobtm1Sgy/J 007683 CByJ.129X1(Cg)-Apobtm1.1Zc/J 007679 SWR.129X1(B6)-Apobtm1.1Zc/J
005061 C57BL/6J-LdlrHlb301/J
Additional Web Information
Cre-lox Systems
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
cre relatedResearch Tools
Cre-lox System (Cre-Recombinase Expression: Inducible)
Genetics Research (Mutagenesis and Transgenesis: Cre-lox System)
Apobtm2Sgy relatedResearch Tools
Cre-lox System
Genetics Research (Mutagenesis and Transgenesis: Cre-lox System)
Ldlrtm1Her relatedCardiovascular Research
Atherosclerosis
Hypocholesterolemia
Hypotriglyceridemia
Developmental Biology Research
Neural Tube Defects
Mouse/Human Gene Homologs
hypobetalipoproteinemia, familial
Neurobiology Research
Neural Tube Defects
Mttptm2Sgy relatedCardiovascular Research
Atherosclerosis
Hypercholesterolemia
Metabolism Research
Lipid Metabolism
Mouse/Human Gene Homologs
hypercholesterolemia, familial
Metabolism Research
Lipid Metabolism
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Apobtm2Sgy | ||
|---|---|---|---|
| Allele Name | targeted mutation 2, Stephen G Young | ||
| Allele Type | Targeted (knock-out) | ||
| Common Name(s) | apo-B100; | ||
| Mutation Made By | Stephen Young, Gladstone Institutes UCSF | ||
| Strain of Origin | 129S7/SvEvBrd-Hprt1<+> | ||
| ES Cell Line Name | AB1 | ||
| ES Cell Line Strain | 129S7/SvEvBrd-Hprt1<+> | ||
| Gene Symbol and Name | Apob, apolipoprotein B | ||
| Chromosome | 12 | ||
| Gene Common Name(s) | AI315052; Aa1064; Ac1-060; ApoB-100; ApoB-48; FLDB; expressed sequence AI315052; | ||
| Molecular Note | A "hit and run"-type vector was used to create a CTA to TTA mutation in codon 2153 in sequences corresponding to the apo-B48 editing codon. Western blot analysis on plasma derived from heterozygous and homozygous mice demostrated that the expression of the ApoB100 isoform is unaffected by this mutation, while no ApoB48 isoform is produced from this allele. [MGI Ref ID J:33830] | ||
| Allele Symbol | Ldlrtm1Her | ||
| Allele Name | targeted mutation 1, Joachim Herz | ||
| Allele Type | Targeted (knock-out) | ||
| Common Name(s) | LDLR KO; LDLR-; LDLr0; LDLrKO; Ldlrtm1Her; | ||
| Mutation Made By | Joachim Herz, Univ of Texas Southwest Med Ctr Dallas | ||
| Strain of Origin | 129S7/SvEvBrd-Hprt1<+> | ||
| ES Cell Line Name | AB1 | ||
| ES Cell Line Strain | 129S7/SvEvBrd-Hprt1<+> | ||
| Gene Symbol and Name | Ldlr, low density lipoprotein receptor | ||
| Chromosome | 9 | ||
| Gene Common Name(s) | FH; FHC; | ||
| General Note | When used in bone marrow transplant into Ldlrtm1Her homozygous mice, Abca1tm1Jdm Abcg1tm1Dgen homozygous cells accelerate the development of atherosclerosis. (J:130777) | ||
| Molecular Note | Insertion of a neomycin resistance cassette into exon 4. The authors predict that the targeted allele would encode a truncated non-functional protein that will not bind LDL, and that lacks a membrane spanning segment. Immunoblot analysis of liver membranes detected a truncated protein in homozygous mutant animals. [MGI Ref ID J:37394] | ||
| Allele Symbol | Mttptm2Sgy | ||
| Allele Name | targeted mutation 2, Steven G Young | ||
| Allele Type | Targeted (Floxed/Frt) | ||
| Mutation Made By | Stephen Young, Gladstone Institutes UCSF | ||
| Strain of Origin | 129S4/SvJae | ||
| Site of Expression | cre mutation deletes floxed Mttp gene, reversing hypercholesterolemia phenotype | ||
| Gene Symbol and Name | Mttp, microsomal triglyceride transfer protein | ||
| Chromosome | 3 | ||
| Gene Common Name(s) | ABL; MGC149819; MGC149820; MTP; | ||
| Molecular Note | A neomycin resistance cassette flanked by loxP sites was inserted into intron 1. An additional loxP site was inserted 2.5 kb upstream of the promoter and exon 1. [MGI Ref ID J:54612] | ||
| Allele Symbol | Tg(Mx1-cre)1Cgn | ||
| Allele Name | transgene insertion 1, University of Cologne | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | Mx-Cre; Mx-Cre 31; Mx1-Cre; Mx1cre; MxCre; | ||
| Mutation Made By | Ralf Kuhn, University of Cologne | ||
| Strain of Origin | (C57BL/6 x CBA)F2 | ||
| Site of Expression | widespread pattern of expression; promoter induced to high levels of transcription by administration of interferon alpha, interferon beta, or synthetic double-stranded RNA; provides capability to induce the "knockout" at any time during development | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | Mx1, myxovirus (influenza virus) resistance 1, mouse, laboratory | ||
| Molecular Note | This transgene expresses Cre recombinase under the control of an inducible Mx1 promoter, which is silent in healthy mice, and active in the liver and in lymphocytes after induction with IFN or pI-pC. The construct also contains a 2.1 kb fragment from thehuman growth hormone gene. [MGI Ref ID J:105040] [MGI Ref ID J:67927] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Apobtm2Sgy, REST, vers. 1
Ldlr tm1Her, STD PCR, vers. 2
Helpful Links
Optimizing PCR Protocols
References
References
Selected Reference(s)
Veniant MM; Withycombe S; Young SG. 2001. Lipoprotein size and atherosclerosis susceptibility in Apoe(-/-) and Ldlr(-/-) mice. Arterioscler Thromb Vasc Biol 21(10):1567-70. [PubMed: 11597927] [MGI Ref ID J:109864]
Additional References
Lieu HD; Withycombe SK; Walker Q; Rong JX; Walzem RL; Wong JS; Hamilton RL; Fisher EA; Young SG. 2003. Eliminating atherogenesis in mice by switching off hepatic lipoprotein secretion. Circulation 107(9):1315-21. [PubMed: 12628954] [MGI Ref ID J:91722]
Apobtm2Sgy relatedLdlrtm1Her relatedAnant S; Murmu N; Houchen CW; Mukhopadhyay D; Riehl TE; Young SG; Morrison AR; Stenson WF; Davidson NO. 2004. Apobec-1 protects intestine from radiation injury through posttranscriptional regulation of cyclooxygenase-2 expression. Gastroenterology 127(4):1139-49. [PubMed: 15480992] [MGI Ref ID J:93425]
Bell TA rd; Kelley K; Wilson MD; Sawyer JK; Rudel LL. 2007. Dietary fat-induced alterations in atherosclerosis are abolished by ACAT2-deficiency in ApoB100 only, LDLr-/- mice. Arterioscler Thromb Vasc Biol 27(6):1396-402. [PubMed: 17431188] [MGI Ref ID J:134910]
Bretillon L; Acar N; Seeliger MW; Santos M; Maire MA; Juaneda P; Martine L; Gregoire S; Joffre C; Bron AM; Creuzot-Garcher C. 2008. ApoB100,LDLR-/- mice exhibit reduced electroretinographic response and cholesteryl esters deposits in the retina. Invest Ophthalmol Vis Sci 49(4):1307-14. [PubMed: 18385042] [MGI Ref ID J:136142]
Conde-Knape K; Okada K; Ramakrishnan R; Shachter NS. 2004. Overexpression of apoC-III produces lesser hypertriglyceridemia in apoB-48-only gene-targeted mice than in apoB-100-only mice. J Lipid Res 45(12):2235-44. [PubMed: 15342689] [MGI Ref ID J:94159]
Degrace P; Moindrot B; Mohamed I; Gresti J; Du ZY; Chardigny JM; Sebedio JL; Clouet P. 2006. Upregulation of liver VLDL receptor and FAT/CD36 expression in LDLR-/- apoB100/100 mice fed trans-10,cis-12 conjugated linoleic acid. J Lipid Res 47(12):2647-55. [PubMed: 16957181] [MGI Ref ID J:117203]
Farese RVJr; Veniant MM; Cham CM; Flynn LM; Pierotti V; Loring JF; Traber M; Ruland S; Stokowski RS; Huszar D; Young SG. 1996. Phenotypic analysis of mice expressing exclusively apolipoprotein B48 or apolipoprotein B100. Proc Natl Acad Sci U S A 93(13):6393-8. [PubMed: 8692825] [MGI Ref ID J:33830]
Iqbal J; Rudel LL; Hussain MM. 2008. Microsomal triglyceride transfer protein enhances cellular cholesteryl esterification by relieving product inhibition. J Biol Chem 283(29):19967-80. [PubMed: 18502767] [MGI Ref ID J:138737]
Kim E; Cham CM; Veniant MM; Ambroziak P; Young SG. 1998. Dual mechanisms for the low plasma levels of truncated apolipoprotein B proteins in familial hypobetalipoproteinemia. Analysis of a new mouse model with a nonsense mutation in the Apob gene. J Clin Invest 101(6):1468-77. [PubMed: 9502790] [MGI Ref ID J:46549]
Kovacs A; Tornvall P; Nilsson R; Tegner J; Hamsten A; Bjorkegren J. 2007. Human C-reactive protein slows atherosclerosis development in a mouse model with human-like hypercholesterolemia. Proc Natl Acad Sci U S A 104(34):13768-73. [PubMed: 17702862] [MGI Ref ID J:124095]
Lieu HD; Withycombe SK; Walker Q; Rong JX; Walzem RL; Wong JS; Hamilton RL; Fisher EA; Young SG. 2003. Eliminating atherogenesis in mice by switching off hepatic lipoprotein secretion. Circulation 107(9):1315-21. [PubMed: 12628954] [MGI Ref ID J:91722]
Lloyd DJ; McCormick J; Helmering J; Kim KW; Wang M; Fordstrom P; Kaufman SA; Lindberg RA; Veniant MM. 2008. Generation and characterization of two novel mouse models exhibiting the phenotypes of the metabolic syndrome: Apob48-/-Lepob/ob mice devoid of ApoE or Ldlr. Am J Physiol Endocrinol Metab 294(3):E496-505. [PubMed: 18160459] [MGI Ref ID J:133453]
Skogsberg J; Lundstrom J; Kovacs A; Nilsson R; Noori P; Maleki S; Kohler M; Hamsten A; Tegner J; Bjorkegren J. 2008. Transcriptional profiling uncovers a network of cholesterol-responsive atherosclerosis target genes. PLoS Genet 4(3):e1000036. [PubMed: 18369455] [MGI Ref ID J:136835]
Veniant MM; Pierotti V; Newland D; Cham CM; Sanan DA; Walzem RL ; Young SG. 1997. Susceptibility to atherosclerosis in mice expressing exclusively apolipoprotein B48 or apolipoprotein B100. J Clin Invest 100(1):180-8. [PubMed: 9202070] [MGI Ref ID J:41510]
Veniant MM; Sullivan MA; Kim SK; Ambroziak P; Chu A; Wilson MD; Hellerstein MK; Rudel LL; Walzem RL; Young SG. 2000. Defining the atherogenicity of large and small lipoproteins containing apolipoprotein B100 J Clin Invest 106(12):1501-10. [PubMed: 11120757] [MGI Ref ID J:66424]
Veniant MM; Zlot CH; Walzem RL; Pierotti V; Driscoll R; Dichek D ; Herz J ; Young SG. 1998. Lipoprotein clearance mechanisms in LDL receptor-deficient Apo-B48-only and Apo-B100-only mice. J Clin Invest 102(8):1559-68. [PubMed: 9788969] [MGI Ref ID J:51022]
Accad M; Smith SJ; Newland DL; Sanan DA; King LE Jr; Linton MF; Fazio S; Farese RV Jr. 2000. Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1 [see comments] J Clin Invest 105(6):711-9. [PubMed: 10727439] [MGI Ref ID J:61147]
Afek A; Keren G; Harats D; George J. 2001. Whole body hyperthermia accelerates atherogenesis in low-density lipoprotein receptor deficient mice. Exp Mol Pathol 71(1):63-72. [PubMed: 11502098] [MGI Ref ID J:106255]
Ait-Oufella H; Kinugawa K; Zoll J; Simon T; Boddaert J; Heeneman S; Blanc-Brude O; Barateau V; Potteaux S; Merval R; Esposito B; Teissier E; Daemen MJ; Leseche G; Boulanger C; Tedgui A; Mallat Z. 2007. Lactadherin deficiency leads to apoptotic cell accumulation and accelerated atherosclerosis in mice. Circulation 115(16):2168-77. [PubMed: 17420351] [MGI Ref ID J:135906]
Ait-Oufella H; Salomon BL; Potteaux S; Robertson AK; Gourdy P; Zoll J; Merval R; Esposito B; Cohen JL; Fisson S; Flavell RA; Hansson GK; Klatzmann D; Tedgui A; Mallat Z. 2006. Natural regulatory T cells control the development of atherosclerosis in mice. Nat Med 12(2):178-80. [PubMed: 16462800] [MGI Ref ID J:105800]
Allred KF; Smart EJ; Wilson ME. 2006. Estrogen receptor-alpha mediates gender differences in atherosclerosis induced by HIV protease inhibitors. J Biol Chem 281(3):1419-25. [PubMed: 16299001] [MGI Ref ID J:107322]
Angeli V; Llodra J; Rong JX; Satoh K; Ishii S; Shimizu T; Fisher EA; Randolph GJ. 2004. Dyslipidemia associated with atherosclerotic disease systemically alters dendritic cell mobilization. Immunity 21(4):561-74. [PubMed: 15485633] [MGI Ref ID J:93917]
Arai S; Shelton JM; Chen M; Bradley MN; Castrillo A; Bookout AL; Mak PA; Edwards PA; Mangelsdorf DJ; Tontonoz P; Miyazaki T. 2005. A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development. Cell Metab 1(3):201-13. [PubMed: 16054063] [MGI Ref ID J:129845]
Aslanian AM; Chapman HA; Charo IF. 2005. Transient role for CD1d-restricted natural killer T cells in the formation of atherosclerotic lesions. Arterioscler Thromb Vasc Biol 25(3):628-32. [PubMed: 15591216] [MGI Ref ID J:110061]
Aslanian AM; Charo IF. 2006. Targeted disruption of the scavenger receptor and chemokine CXCL16 accelerates atherosclerosis. Circulation 114(6):583-90. [PubMed: 16880330] [MGI Ref ID J:123851]
Azhar S; Luo Y; Medicherla S; Reaven E. 1999. Upregulation of selective cholesteryl ester uptake pathway in mice with deletion of low-density lipoprotein receptor function. J Cell Physiol 180(2):190-202. [PubMed: 10395289] [MGI Ref ID J:56099]
Babaev VR; Ding L; Reese J; Morrow JD; Breyer MD; Dey SK; Fazio S; Linton MF. 2006. Cyclooxygenase-1 deficiency in bone marrow cells increases early atherosclerosis in apolipoprotein E- and low-density lipoprotein receptor-null mice. Circulation 113(1):108-17. [PubMed: 16380543] [MGI Ref ID J:121507]
Babaev VR; Ishiguro H; Ding L; Yancey PG; Dove DE; Kovacs WJ; Semenkovich CF; Fazio S; Linton MF. 2007. Macrophage expression of peroxisome proliferator-activated receptor-alpha reduces atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation 116(12):1404-12. [PubMed: 17724261] [MGI Ref ID J:139843]
Babaev VR; Yancey PG; Ryzhov SV; Kon V; Breyer MD; Magnuson MA; Fazio S; Linton MF. 2005. Conditional knockout of macrophage PPARgamma increases atherosclerosis in C57BL/6 and low-density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol 25(8):1647-53. [PubMed: 15947238] [MGI Ref ID J:114332]
Baldan A; Pei L; Lee R; Tarr P; Tangirala RK; Weinstein MM; Frank J; Li AC; Tontonoz P; Edwards PA. 2006. Impaired development of atherosclerosis in hyperlipidemic Ldlr-/- and ApoE-/- mice transplanted with Abcg1-/- bone marrow. Arterioscler Thromb Vasc Biol 26(10):2301-7. [PubMed: 16888235] [MGI Ref ID J:128048]
Barlic J; Murphy PM. 2007. Chemokine regulation of atherosclerosis. J Leukoc Biol 82(2):226-36. [PubMed: 17329566] [MGI Ref ID J:123530]
Basso F; Amar MJ; Wagner EM; Vaisman B; Paigen B; Santamarina-Fojo S; Remaley AT. 2006. Enhanced ABCG1 expression increases atherosclerosis in LDLr-KO mice on a western diet. Biochem Biophys Res Commun 351(2):398-404. [PubMed: 17070501] [MGI Ref ID J:116554]
Basso F; Freeman LA; Ko C; Joyce C; Amar MJ; Shamburek RD; Tansey T; Thomas F; Wu J; Paigen B; Remaley AT; Santamarina-Fojo S; Brewer HB Jr. 2007. Hepatic ABCG5/G8 overexpression reduces apoB-lipoproteins and atherosclerosis when cholesterol absorption is inhibited. J Lipid Res 48(1):114-26. [PubMed: 17060690] [MGI Ref ID J:117682]
Bavendiek U; Zirlik A; LaClair S; MacFarlane L; Libby P; Schonbeck U. 2005. Atherogenesis in mice does not require CD40 ligand from bone marrow-derived cells. Arterioscler Thromb Vasc Biol 25(6):1244-9. [PubMed: 15746436] [MGI Ref ID J:114293]
Bell TA rd; Kelley K; Wilson MD; Sawyer JK; Rudel LL. 2007. Dietary fat-induced alterations in atherosclerosis are abolished by ACAT2-deficiency in ApoB100 only, LDLr-/- mice. Arterioscler Thromb Vasc Biol 27(6):1396-402. [PubMed: 17431188] [MGI Ref ID J:134910]
Bernal-Mizrachi C; Weng S; Feng C; Finck BN; Knutsen RH; Leone TC; Coleman T; Mecham RP; Kelly DP; Semenkovich CF. 2003. Dexamethasone induction of hypertension and diabetes is PPAR-alpha dependent in LDL receptor-null mice. Nat Med 9(8):1069-75. [PubMed: 12847522] [MGI Ref ID J:84844]
Bernhagen J; Krohn R; Lue H; Gregory JL; Zernecke A; Koenen RR; Dewor M; Georgiev I; Schober A; Leng L; Kooistra T; Fingerle-Rowson G; Ghezzi P; Kleemann R; McColl SR; Bucala R; Hickey MJ; Weber C. 2007. MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment. Nat Med 13(5):587-596. [PubMed: 17435771] [MGI Ref ID J:121807]
Bhatia VK; Yun S; Leung V; Grimsditch DC; Benson GM; Botto MB; Boyle JJ; Haskard DO. 2007. Complement C1q reduces early atherosclerosis in low-density lipoprotein receptor-deficient mice. Am J Pathol 170(1):416-26. [PubMed: 17200212] [MGI Ref ID J:117210]
Binder CJ; Hartvigsen K; Chang MK; Miller M; Broide D; Palinski W; Curtiss LK; Corr M; Witztum JL. 2004. IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis. J Clin Invest 114(3):427-37. [PubMed: 15286809] [MGI Ref ID J:118092]
Binder CJ; Horkko S; Dewan A; Chang MK; Kieu EP; Goodyear CS; Shaw PX; Palinski W; Witztum JL; Silverman GJ. 2003. Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL. Nat Med 9(6):736-43. [PubMed: 12740573] [MGI Ref ID J:83726]
Blasiole DA; Oler AT; Attie AD. 2008. Regulation of ApoB secretion by the low density lipoprotein receptor requires exit from the endoplasmic reticulum and interaction with ApoE or ApoB. J Biol Chem 283(17):11374-81. [PubMed: 18272520] [MGI Ref ID J:136523]
Boisvert WA; Rose DM; Johnson KA; Fuentes ME; Lira SA; Curtiss LK; Terkeltaub RA. 2006. Up-regulated expression of the CXCR2 Ligand KC/GRO-alpha in atherosclerotic lesions plays a central role in macrophage accumulation and lesion progression. Am J Pathol 168(4):1385-95. [PubMed: 16565511] [MGI Ref ID J:107325]
Boisvert WA; Santiago R; Curtiss LK; Terkeltaub RA. 1998. A leukocyte homologue of the IL-8 receptor CXCR-2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice. J Clin Invest 101(2):353-63. [PubMed: 9435307] [MGI Ref ID J:45392]
Boucher P; Gotthardt M; Li WP; Anderson RG; Herz J. 2003. LRP: role in vascular wall integrity and protection from atherosclerosis. Science 300(5617):329-32. [PubMed: 12690199] [MGI Ref ID J:82871]
Boucher P; Li WP; Matz RL; Takayama Y; Auwerx J; Anderson RG; Herz J. 2007. LRP1 functions as an atheroprotective integrator of TGFbeta and PDFG signals in the vascular wall: implications for Marfan syndrome. PLoS ONE 2(5):e448. [PubMed: 17505534] [MGI Ref ID J:129347]
Bovenschen N; Mertens K; Hu L; Havekes LM; van Vlijmen BJ. 2005. LDL receptor cooperates with LDL receptor-related protein in regulating plasma levels of coagulation factor VIII in vivo. Blood 106(3):906-12. [PubMed: 15840700] [MGI Ref ID J:117317]
Boyanovsky BB; van der Westhuyzen DR; Webb NR. 2005. Group V secretory phospholipase A2-modified low density lipoprotein promotes foam cell formation by a SR-A- and CD36-independent process that involves cellular proteoglycans. J Biol Chem 280(38):32746-52. [PubMed: 16040605] [MGI Ref ID J:102157]
Bretillon L; Acar N; Seeliger MW; Santos M; Maire MA; Juaneda P; Martine L; Gregoire S; Joffre C; Bron AM; Creuzot-Garcher C. 2008. ApoB100,LDLR-/- mice exhibit reduced electroretinographic response and cholesteryl esters deposits in the retina. Invest Ophthalmol Vis Sci 49(4):1307-14. [PubMed: 18385042] [MGI Ref ID J:136142]
Broedl UC; Maugeais C; Millar JS; Jin W; Moore RE; Fuki IV; Marchadier D; Glick JM; Rader DJ. 2004. Endothelial lipase promotes the catabolism of ApoB-containing lipoproteins. Circ Res 94(12):1554-61. [PubMed: 15117821] [MGI Ref ID J:100064]
Brown JM; Bell TA rd; Alger HM; Sawyer JK; Smith TL; Kelley K; Shah R; Wilson MD; Davis MA; Lee RG; Graham MJ; Crooke RM; Rudel LL. 2008. Targeted depletion of hepatic ACAT2-driven cholesterol esterification reveals a non-biliary route for fecal neutral sterol loss. J Biol Chem 283(16):10522-34. [PubMed: 18281279] [MGI Ref ID J:136556]
Buga GM; Frank JS; Mottino GA; Hakhamian A; Narasimha A; Watson AD; Yekta B; Navab M; Reddy ST; Anantharamaiah GM; Fogelman AM. 2008. D-4F reduces EO6 immunoreactivity, SREBP-1c mRNA levels, and renal inflammation in LDL receptor-null mice fed a Western diet. J Lipid Res 49(1):192-205. [PubMed: 17925450] [MGI Ref ID J:130095]
Buga GM; Frank JS; Mottino GA; Hendizadeh M; Hakhamian A; Tillisch JH; Reddy ST; Navab M; Anantharamaiah GM; Ignarro LJ; Fogelman AM. 2006. D-4F decreases brain arteriole inflammation and improves cognitive performance in LDL receptor-null mice on a Western diet. J Lipid Res 47(10):2148-60. [PubMed: 16835442] [MGI Ref ID J:116493]
Buono C; Binder CJ; Stavrakis G; Witztum JL; Glimcher LH; Lichtman AH. 2005. T-bet deficiency reduces atherosclerosis and alters plaque antigen-specific immune responses. Proc Natl Acad Sci U S A 102(5):1596-601. [PubMed: 15665085] [MGI Ref ID J:96110]
Buono C; Come CE; Stavrakis G; Maguire GF; Connelly PW; Lichtman AH. 2003. Influence of interferon-gamma on the extent and phenotype of diet-induced atherosclerosis in the LDLR-deficient mouse. Arterioscler Thromb Vasc Biol 23(3):454-60. [PubMed: 12615659] [MGI Ref ID J:103072]
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