Strain Name:

STOCK Mttptm2Sgy Ldlrtm1Her Apobtm2Sgy Tg(Mx1-cre)1Cgn/J

Stock Number:


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The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names STOCK Mttptm2Sgy Ldlrtm1Her Apobtm2Sgy TgN(Mx1-cre)1Cgn    (Changed: 15-DEC-04 )
STOCK-Mttptm1SgyLdlrtm1SgyApobtm1SgyTgN(Mx-Cre)1Cgn    (Changed: 15-DEC-04 )
STOCK-Mttptm2Sgy Ldlrtm1Her Apobtm2Sgy TgN(Mx1-Cre)1Cgn    (Changed: 15-DEC-04 )
STOCK-Mttptm2Sgy Ldlrtm1Her Apobtm2Sgy TgN(Mx1-cre)1Cgn    (Changed: 15-DEC-04 )
Type Targeted Mutation; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
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Specieslaboratory mouse
Donating InvestigatorDr. Stephen Young,   Gladstone Institutes UCSF

These mice are homozygous for four different induced mutations. The cumulative result of these mutations is a mouse model in which hypercholesterolemia can be reversed. By themselves, the combined presence of the Ldlrtm1Sgy and Apobtm1Sgy targeted alleles results in mice with a high susceptibility to atherosclerosis and total plasma cholesterol levels of approximately 300 mg/dl. A functional microsomal triglyceride transfer protein gene (Mttp) is essential for establishing a hypercholesterolemic condition. By flanking the Mttp gene with loxP sites and including a Mx1-Cre transgene, it is possible to reduce total plasma cholesterol levels from 300 mg/dl to 30 mg/dl upon induction of the Cre recombinase by administering interferon alpha, interferon beta, or synthetic double-stranded RNA. This unique model is useful in research related to the mechanisms and events of atherosclerotic reversal. Mice homozygous for the targeted alleles are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities.

The donating investigator combined existing induced alleles to create this model. See Stock No's 003902, 002077, 002877 and 003556.

Related Strains

Strains carrying   Apobtm2Sgy allele
002879   B6;129-Apobtm2Sgy Apoetm1Unc/J
003000   B6;129S-Ldlrtm1Her Apobtm2Sgy/J
002877   B6;129S7-Apobtm2Sgy/J
View Strains carrying   Apobtm2Sgy     (3 strains)

View Strains carrying   Ldlrtm1Her     (15 strains)

Strains carrying   Mttptm2Sgy allele
003902   B6;129S-Mttptm2Sgy/J
View Strains carrying   Mttptm2Sgy     (1 strain)

Strains carrying   Tg(Mx1-cre)1Cgn allele
006230   B6.Cg-Cebpatm1Dgt Tg(Mx1-cre)1Cgn/J
003556   B6.Cg-Tg(Mx1-cre)1Cgn/J
005673   C.Cg-Tg(Mx1-cre)1Cgn/J
002527   STOCK Tg(Mx1-cre)1Cgn/J
View Strains carrying   Tg(Mx1-cre)1Cgn     (4 strains)

Strains carrying other alleles of Apob
002053   B6.129P2-Apobtm1Unc/J
007682   B6.129X1-Apobtm1.1Zc/J
002878   B6;129-Apobtm1Sgy Apoetm1Unc/J
002876   B6;129S-Apobtm1Sgy/J
007683   CByJ.129X1(Cg)-Apobtm1.1Zc/J
007679   SWR.129X1(B6)-Apobtm1.1Zc/J
View Strains carrying other alleles of Apob     (6 strains)

View Strains carrying other alleles of Ldlr     (4 strains)

Strains carrying other alleles of cre
004337   129(Cg)-Foxg1tm1(cre)Skm/J
008569   129-Alpltm1(cre)Nagy/J
005989   129;FVB-Tg(PTH-cre)4167Slib/J
007179   129S.Cg-Tg(UBC-cre/ERT2)1Ejb/J
007915   129S.FVB-Tg(Amh-cre)8815Reb/J
003328   129S/Sv-Tg(Prm-cre)58Og/J
026200   129S1.Cg-Tg(Vsx2-cre)2690Chow/J
004302   129S1/Sv-Hprttm1(cre)Mnn/J
022137   129S4.Cg-Tg(Wnt1-cre)2Sor/J
003960   129S6-Tg(Prnp-GFP/cre)1Blw/J
008523   129S6.Cg-Tg(NPHS2-cre)295Lbh/BroJ
009587   B6(129S4)-Et(icre)1402Rdav/J
009588   B6(129S4)-Et(icre)1470Rdav/J
009589   B6(129S4)-Et(icre)1555Rdav/J
009586   B6(129S4)-Et(icre)754Rdav/J
012687   B6(129S4)-Tg(SYN1-icre/mRFP1)9934Rdav/J
010774   B6(Cg)-Calb2tm1(cre)Zjh/J
017562   B6(Cg)-Cd8atm1.1(cre)Koni/J
012704   B6(Cg)-Crhtm1(cre)Zjh/J
018448   B6(Cg)-Foxn1tm3(cre)Nrm/J
026801   B6(Cg)-Ins1tm1.1(cre)Thor/J
016223   B6(Cg)-Tg(Phox2b-cre)3Jke/J
016959   B6.129(Cg)-Foxp3tm4(YFP/cre)Ayr/J
023055   B6.129(Cg)-Krt12tm3(cre)Wwk/J
008320   B6.129-Leprtm2(cre)Rck/J
017526   B6.129-Nos1tm1(cre)Mgmj/J
005697   B6.129-Otx1tm4(cre)Asim/J
018938   B6.129-Tac2tm1.1(cre)Qima/J
017769   B6.129-Trpv1tm1(cre)Bbm/J
004146   B6.129-Tg(Pcp2-cre)2Mpin/J
008710   B6.129P2(129S4)-Hprttm10(Ple162-EGFP/cre)Ems/Mmjax
008877   B6.129P2(129S4)-Hprttm12(Ple177-EGFP/cre)Ems/Mmjax
009116   B6.129P2(129S4)-Hprttm16(Ple167-EGFP/cre)Ems/Mmjax
008709   B6.129P2(129S4)-Hprttm9(Ple178-EGFP/cre)Ems/Mmjax
006785   B6.129P2(C)-Cd19tm1(cre)Cgn/J
006084   B6.129P2(Cg)-Foxg1tm1(cre)Skm/J
010611   B6.129P2(Cg)-Ighg1tm1(IRES-cre)Cgn/J
007770   B6.129P2-Aicdatm1(cre)Mnz/J
004781   B6.129P2-Lyz2tm1(cre)Ifo/J
017320   B6.129P2-Pvalbtm1(cre)Arbr/J
017915   B6.129S(Cg)-Pgrtm1.1(cre)Shah/AndJ
013594   B6.129S-Atoh1tm5.1(Cre/PGR)Hzo/J
021794   B6.129S1(Cg)-Ascl3tm1.1(EGFP/cre)Ovi/J
024637   B6.129S1(SJL)-Nkx2-5tm2(cre)Rph/J
006600   B6.129S1-Mnx1tm4(cre)Tmj/J
005628   B6.129S2-Emx1tm1(cre)Krj/J
022510   B6.129S4-Gpr88tm1.1(cre/GFP)Rpa/J
017578   B6.129S4-Mcpt8tm1(cre)Lky/J
003755   B6.129S4-Meox2tm1(cre)Sor/J
007893   B6.129S4-Myf5tm3(cre)Sor/J
006878   B6.129S6-Taglntm2(cre)Yec/J
012839   B6.129X1(Cg)-Tnfrsf4tm2(cre)Nik/J
008712   B6.129X1-Twist2tm1.1(cre)Dor/J
006054   B6.C-Tg(CMV-cre)1Cgn/J
020811   B6.C-Tg(Pgk1-cre)1Lni/CrsJ
023530   B6.Cg-Avptm1.1(cre)Hze/J
013590   B6.Cg-Braftm1Mmcm Ptentm1Hwu Tg(Tyr-cre/ERT2)13Bos/BosJ
012358   B6.Cg-Pvalbtm1.1(cre)Aibs/J
005622   B6.Cg-Shhtm1(EGFP/cre)Cjt/J
022762   B6.Cg-Zfp335tm1.2Caw Emx1tm1(cre)Krj/J
017346   B6.Cg-Tg(A930038C07Rik-cre)1Aibs/J
006149   B6.Cg-Tg(ACTA1-cre)79Jme/J
003574   B6.Cg-Tg(Alb-cre)21Mgn/J
006881   B6.Cg-Tg(Aqp2-cre)1Dek/J
011104   B6.Cg-Tg(Atoh1-cre)1Bfri/J
008520   B6.Cg-Tg(CD2-cre)4Kio/J
009350   B6.Cg-Tg(CDX2-cre)101Erf/J
009352   B6.Cg-Tg(CDX2-cre*)189Erf/J
027310   B6.Cg-Tg(Camk2a-cre)2Szi/J
027400   B6.Cg-Tg(Camk2a-cre)3Szi/J
005359   B6.Cg-Tg(Camk2a-cre)T29-1Stl/J
022071   B6.Cg-Tg(Cd4-cre)1Cwi/BfluJ
012237   B6.Cg-Tg(Cdh16-cre)91Igr/J
006368   B6.Cg-Tg(Cr2-cre)3Cgn/J
006663   B6.Cg-Tg(Eno2-cre)39Jme/J
005069   B6.Cg-Tg(Fabp4-cre)1Rev/J
012712   B6.Cg-Tg(Fev-cre)1Esd/J
012849   B6.Cg-Tg(GFAP-cre/ERT2)505Fmv/J
012886   B6.Cg-Tg(Gfap-cre)73.12Mvs/J
024098   B6.Cg-Tg(Gfap-cre)77.6Mvs/2J
009642   B6.Cg-Tg(Gh1-cre)1Sac/J
024474   B6.Cg-Tg(Il9-cre)#Stck/J
003573   B6.Cg-Tg(Ins2-cre)25Mgn/J
008068   B6.Cg-Tg(Itgax-cre)1-1Reiz/J
008781   B6.Cg-Tg(Kap-cre)29066/2Sig/J
003802   B6.Cg-Tg(Lck-cre)548Jxm/J
006889   B6.Cg-Tg(Lck-cre)I540Jxm/J
012837   B6.Cg-Tg(Lck-icre)3779Nik/J
009643   B6.Cg-Tg(Lhb-cre)1Sac/J
008330   B6.Cg-Tg(Mc4r-cre)25Rck/J
007742   B6.Cg-Tg(Myh11-cre,-EGFP)2Mik/J
008205   B6.Cg-Tg(NPHS2-cre)295Lbh/J
003771   B6.Cg-Tg(Nes-cre)1Kln/J
010536   B6.Cg-Tg(Pcp2-cre)3555Jdhu/J
005975   B6.Cg-Tg(Plp1-cre/ERT)3Pop/J
008827   B6.Cg-Tg(Prdm1-cre)1Masu/J
005584   B6.Cg-Tg(Prrx1-cre)1Cjt/J
003967   B6.Cg-Tg(Rbp3-cre)528Jxm/J
021614   B6.Cg-Tg(S100A8-cre,-EGFP)1Ilw/J
008454   B6.Cg-Tg(Sox2-cre)1Amc/J
006361   B6.Cg-Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/J
003966   B6.Cg-Tg(Syn1-cre)671Jxm/J
017491   B6.Cg-Tg(Tagln-cre)1Her/J
004128   B6.Cg-Tg(Tek-cre)12Flv/J
008863   B6.Cg-Tg(Tek-cre)1Ywa/J
008601   B6.Cg-Tg(Th-cre)1Tmd/J
012328   B6.Cg-Tg(Tyr-cre/ERT2)13Bos/J
008085   B6.Cg-Tg(UBC-cre/ERT2)1Ejb/J
008610   B6.Cg-Tg(Vav1-cre)A2Kio/J
004586   B6.Cg-Tg(Vil-cre)997Gum/J
021504   B6.Cg-Tg(Vil1-cre)1000Gum/J
008735   B6.Cg-Tg(Wap-cre)11738Mam/JKnwJ
009614   B6.Cg-Tg(Wfs1-cre/ERT2)2Aibs/J
009107   B6.Cg-Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J
022501   B6.Cg-Tg(Wnt1-cre)2Sor/J
006234   B6.Cg-Tg(tetO-cre)1Jaw/J
016832   B6.FVB(129)-Tg(Alb1-cre)1Dlr/J
005657   B6.FVB(129)-Tg(Myh6-cre/Esr1*)1Jmk/J
024688   B6.FVB(129S)-Tg(Pax6-GFP/cre)1Rilm/J
006475   B6.FVB(129S4)-Tg(Ckmm-cre)5Khn/J
006451   B6.FVB(129X1)-Tg(Sim1-cre)1Lowl/J
006333   B6.FVB(Cg)-Tg(Neurog3-cre)C1Able/J
014643   B6.FVB-Tg(CMA1-cre)6Thhe/J
006137   B6.FVB-Tg(Cdh5-cre)7Mlia/J
018980   B6.FVB-Tg(Ddx4-cre)1Dcas/KnwJ
003724   B6.FVB-Tg(EIIa-cre)C5379Lmgd/J
011069   B6.FVB-Tg(Gh1-cre)bKnmn/J
011038   B6.FVB-Tg(Myh6-cre)2182Mds/J
014647   B6.FVB-Tg(Pdx1-cre)6Tuv/J
010714   B6.FVB-Tg(Pomc-cre)1Lowl/J
022791   B6.FVB-Tg(Rorc-cre)1Litt/J
017535   B6.FVB-Tg(Slc32a1-cre)2.1Hzo/FrkJ
017490   B6.FVB-Tg(Stra8-icre)1Reb/LguJ
024670   B6.FVB-Tg(Ucp1-cre)1Evdr/J
003394   B6.FVB-Tg(Zp3-cre)3Mrt/J
006660   B6.SJL-Slc6a3tm1.1(cre)Bkmn/J
003552   B6129-Tg(Wap-cre)11738Mam/J
023161   B6129S-Tg(Foxp3-EGFP/cre)1aJbs/J
021025   B6;129-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm1(tetO-cre)Haho/J
010529   B6;129-Myf5tm1(cre)Mrc/J
010528   B6;129-Myf6tm2(cre)Mrc/J
017525   B6;129-Ntstm1(cre)Mgmj/J
005549   B6;129-Pax3tm1(cre)Joe/J
017968   B6;129-Tg(Cdh5-cre)1Spe/J
024860   B6;129-Tg(Drd1-cre)120Mxu/Mmjax
010988   B6;129P-Cyp11a1tm1(GFP/cre)Pzg/J
008529   B6;129P-Tg(Neurog1-cre/ERT2)1Good/J
012601   B6;129P2-Lyve1tm1.1(EGFP/cre)Cys/J
006668   B6;129P2-Omptm4(cre)Mom/MomJ
008069   B6;129P2-Pvalbtm1(cre)Arbr/J
012373   B6;129S-Hoxb1tm1(cre)Og/J
024234   B6;129S-Oxttm1.1(cre)Dolsn/J
023526   B6;129S-Rorbtm1.1(cre)Hze/J
023527   B6;129S-Slc17a7tm1.1(cre)Hze/J
023525   B6;129S-Snap25tm2.1(cre)Hze/J
021877   B6;129S-Tac1tm1.1(cre)Hze/J
021878   B6;129S-Tac2tm1.1(cre)Hze/J
017685   B6;129S-Wisp3tm1(cre)Mawa/J
007001   B6;129S-Tg(UBC-cre/ERT2)1Ejb/J
009388   B6;129S1-Osr2tm2(cre)Jian/J
012463   B6;129S4-Foxd1tm1(GFP/cre)Amc/J
011105   B6;129S4-Olig1tm1(cre)Rth/J
006410   B6;129S6-Chattm2(cre)Lowl/J
009616   B6;C3-Tg(A930038C07Rik-cre)4Aibs/J
012433   B6;C3-Tg(ACTA1-rtTA,tetO-cre)102Monk/J
008844   B6;C3-Tg(Ctgf-cre)2Aibs/J
008839   B6;C3-Tg(Cyp39a1-cre)1Aibs/J
009117   B6;C3-Tg(Cyp39a1-cre)7Aibs/J
008848   B6;C3-Tg(Mybpc1-cre)2Aibs/J
009111   B6;C3-Tg(Scnn1a-cre)1Aibs/J
009112   B6;C3-Tg(Scnn1a-cre)2Aibs/J
009613   B6;C3-Tg(Scnn1a-cre)3Aibs/J
009103   B6;C3-Tg(Wfs1-cre/ERT2)3Aibs/J
025806   B6;CBA-Tg(Gsx2-cre)1Kess/J
026555   B6;CBA-Tg(Lhx6-cre)1Kess/J
025807   B6;CBA-Tg(Sox10-cre)1Wdr/J
024507   B6;CBA-Tg(Tbx21-cre)1Dlc/J
017494   B6;D-Tg(Tshz3-GFP/cre)43Amc/J
024926   B6;D2-Tg(Fshr-cre)1Ldu/J
003466   B6;D2-Tg(Sycp1-cre)4Min/J
014160   B6;DBA-Tg(S100b-EGFP/cre/ERT2)22Amc/J
014159   B6;DBA-Tg(Tmem100-EGFP/cre/ERT2)30Amc/J
015855   B6;DBA-Tg(Upk3a-GFP/cre/ERT2)26Amc/J
010803   B6;FVB-Tg(Adipoq-cre)1Evdr/J
018422   B6;FVB-Tg(Aicda-cre)1Rcas/J
023748   B6;FVB-Tg(Aldh1l1-cre)JD1884Gsat/J
011087   B6;FVB-Tg(Crh-cre)1Kres/J
008533   B6;FVB-Tg(Cspg4-cre)1Akik/J
003734   B6;FVB-Tg(GZMB-cre)1Jcb/J
015850   B6;SJL-Pde6b+ Tg(Rho-icre)1Ck/Boc
004426   B6;SJL-Tg(Cga-cre)3Sac/J
003554   B6;SJL-Tg(Col2a1-cre)1Bhr/J
017738   B6;SJL-Tg(Foxl1-cre)1Khk/J
005249   B6;SJL-Tg(Krt1-15-cre/PGR)22Cot/J
019893   B6;SJL-Tg(Tex101-icre)2Lzj/J
007252   B6Ei.129S4-Tg(Prm-cre)58Og/EiJ
025524   B6J.B6N(Cg)-Cx3cr1tm1.1(cre)Jung/J
018956   B6N.129P2(B6)-Lyz2tm1(cre)Ifo/J
018958   B6N.129P2-Cd19tm1(cre)Cgn/J
021077   B6N.129S1-Mrgprb4tm3(cre)And/J
018957   B6N.129S6(B6)-Chattm2(cre)Lowl/J
017911   B6N.129S6(Cg)-Esr1tm1.1(cre)And/J
019013   B6N.129S6(Cg)-Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
018974   B6N.B6-Tg(Nr4a1-EGFP/cre)820Khog/J
019021   B6N.Cg-Ccktm1.1(cre)Zjh/J
019022   B6N.Cg-Gad2tm2(cre)Zjh/J
018973   B6N.Cg-Ssttm2.1(cre)Zjh/J
018961   B6N.Cg-Tg(Alb-cre)21Mgn/J
018966   B6N.Cg-Tg(Camk2a-cre)T29-1Stl/J
018965   B6N.Cg-Tg(Fabp4-cre)1Rev/J
017310   B6N.Cg-Tg(Hsd17b1-icre/ERT2)3Casa/J
018960   B6N.Cg-Tg(Ins2-cre)25Mgn/J
018967   B6N.Cg-Tg(Itgax-cre)1-1Reiz/J
018964   B6N.Cg-Tg(KRT14-cre)1Amc/J
019103   B6N.Cg-Tg(Nes-cre)1Kln/CjDswJ
014094   B6N.Cg-Tg(Sox2-cre)1Amc/J
018968   B6N.Cg-Tg(Vav1-cre)A2Kio/J
018963   B6N.Cg-Tg(Vil-cre)997Gum/J
018972   B6N.FVB(B6)-Tg(Myh6-cre)2182Mds/J
019099   B6N.FVB-Tg(ACTB-cre)2Mrt/CjDswJ
019509   B6N.FVB-Tg(BGLAP-cre)1Clem/J
023047   B6N.FVB-Tg(Dmp1-cre)1Jqfe/BwdJ
017927   B6N.FVB-Tg(Mpz-cre)26Mes/J
003465   BALB/c-Tg(CMV-cre)1Cgn/J
012641   BALB/c-Tg(S100a4-cre)1Egn/YunkJ
010612   C.129P2(Cg)-Ighg1tm1(IRES-cre)Cgn/J
017353   C.129S4(B6)-Il13tm1(YFP/cre)Lky/J
017582   C.129S4(B6)-Mcpt8tm1(cre)Lky/J
004126   C.Cg-Cd19tm1(cre)Cgn Ighb/J
006244   C.Cg-Tg(tetO-cre)1Jaw/J
009155   C57BL/6-Cldn6tm1(cre)Dkwu/J
017557   C57BL/6-Tg(BEST1-cre)1Jdun/J
027406   C57BL/6-Tg(CD2-cre)1Lov/J
016097   C57BL/6-Tg(Car1-cre)5Flt/J
011086   C57BL/6-Tg(Cck-cre)CKres/J
008766   C57BL/6-Tg(Cd8a-cre)1Itan/J
026828   C57BL/6-Tg(Cpa3-cre)4Glli/J
006474   C57BL/6-Tg(Grik4-cre)G32-4Stl/J
008314   C57BL/6-Tg(HBB-cre)12Kpe/J
008870   C57BL/6-Tg(Hspa2-cre)1Eddy/J
016261   C57BL/6-Tg(Nes-cre/ERT2)KEisc/J
012906   C57BL/6-Tg(Nes-cre/Esr1*)1Kuan/J
027205   C57BL/6-Tg(Nms-icre)20Ywa/J
016617   C57BL/6-Tg(Nr4a1-EGFP/cre)820Khog/J
020287   C57BL/6-Tg(Pbsn-cre/Esr1*)14Abch/J
013148   C57BL/6-Tg(Pdgfra-cre)1Clc/J
008535   C57BL/6-Tg(Pf4-cre)Q3Rsko/J
024034   C57BL/6-Tg(Pmch-cre)1Rck/J
016583   C57BL/6-Tg(Slc6a3-icre/ERT2)2Gloss/J
006888   C57BL/6-Tg(Zp3-cre)1Gwh/J
003651   C57BL/6-Tg(Zp3-cre)93Knw/J
021119   C57BL/6J-Tg(Dlx2-cre,-mCherry)4Grsr/GrsrJ
021423   C57BL/6J-Tg(Dlx2-cre,-mCherry)9Grsr/GrsrJ
007567   C57BL/6J-Tg(Itgax-cre,-EGFP)4097Ach/J
018895   C57BL/6J-Tg(Krt6,-cre,-Cerulean)1Grsr/Grsr
018896   C57BL/6J-Tg(Krt6,-cre,-Cerulean)2Grsr/Grsr
018898   C57BL/6J-Tg(Krt6,-cre,-Cerulean)4Grsr/Grsr
018899   C57BL/6J-Tg(Krt6,-cre,-Cerulean)5Grsr/Grsr
021582   C57BL/6J-Tg(Mchr1-cre)1Emf/J
008661   C57BL/6J-Tg(Nkx2-1-cre)2Sand/J
022883   C57BL/6J-Tg(Six6-cre)3Grsr/GrsrJ
022887   C57BL/6J-Tg(Six6-cre)7Grsr/GrsrJ
018754   C57BL/6J-Tg(Tbx22,-cre,-mCherry)1Grsr/GrsrJ
019363   C57BL/6J-Tg(Trp63,-cre,-Cerulean)10Grsr/Grsr
018792   C57BL/6J-Tg(Trp63,-cre,-Cerulean)4Grsr/GrsrJ
003650   C57BL/6J-Tg(Zp3-cre)82Knw/KnwJ
018151   C57BL/6N-Krt17tm1(cre,Cerulean)Murr/GrsrJ
023014   C57BL/6N-Tg(Calcrl,cre)4688Nkza/J
012686   C57BL/6N-Tg(Ppp1r2-cre)4127Nkza/J
016582   C57BL/6N-Tg(Slc32a1-icre/ERT2)3Gloss/J
026861   D2.129P2(B6)-Lyz2tm1(cre)Ifo/SjJ
026858   D2.129S4(B6)-Meox2tm1(cre)Sor/SjJ
026266   D2.B6-Tg(Zp3-cre)93Knw/SjJ
026852   D2.Cg-Tg(Gfap-cre)73.12Mvs/SjJ
024701   D2.Cg-Tg(Plp1-cre/ERT)3Pop/SjJ
026859   D2.Cg-Tg(Sox2-cre)1Amc/SjJ
026857   D2.FVB-Tg(GFAP-cre)25Mes/SjJ
026860   D2.FVB-Tg(Tek-cre)2352Rwng/SjJ
016833   FVB(Cg)-Tg(Alb1-cre)1Dlr/J
012929   FVB(Cg)-Tg(Dhh-cre)1Mejr/J
011034   FVB(Cg)-Tg(Ghrhr-cre)3242Lsk/J
006405   FVB-Tg(Ckmm-cre)5Khn/J
021024   FVB-Tg(Csf1r-icre)1Jwp/J
006954   FVB-Tg(Ddx4-cre)1Dcas/J
004600   FVB-Tg(GFAP-cre)25Mes/J
011037   FVB-Tg(Myh6-cre)2182Mds/J
006364   FVB-Tg(Nr5a1-cre)2Lowl/J
008537   FVB-Tg(Tek-cre)2352Rwng/J
019382   FVB.Cg-Myh9tm1.1Gac Tg(NPHS2-cre)295Lbh/Mmjax
014140   FVB.Cg-Myod1tm2.1(icre)Glh/J
006139   FVB.Cg-Tg(ACTA1-cre)79Jme/J
006297   FVB.Cg-Tg(Eno2-cre)39Jme/J
018394   FVB.Cg-Tg(KRT5-cre/ERT2)2Ipc/JeldJ
008244   FVB.Cg-Tg(tetO-cre)1Jaw/J
003376   FVB/N-Tg(ACTB-cre)2Mrt/J
024384   FVB/N-Tg(AMELX-cre)A1Kul/J
003314   FVB/N-Tg(EIIa-cre)C5379Lmgd/J
025062   FVB/N-Tg(Figla-EGFP,-icre)ZP3Dean/Mmjax
017928   FVB/N-Tg(Mpz-cre)26Mes/J
025066   FVB/N-Tg(Mylpf-cre)3Kraj/Mmjax
006143   FVB/N-Tg(Thy1-cre)1Vln/J
003377   FVB/N-Tg(Zp3-cre)3Mrt/J
023325   FVB;B6-Tg(Pbsn-cre)20Fwan/J
019096   NOD.129P2(B6)-Lyz2tm1(cre)Ifo/NadlJ
023806   NOD.129P2(Cg)-Cd19tm1(cre)Cgn/J
013233   NOD.B6-Tg(Itgax-cre,-EGFP)4097Ach/J
013234   NOD.Cg-Tg(Cd4-cre)1Cwi/2AchJ
023972   NOD.Cg-Tg(Ins2-cre/ERT)1Dam/SbwJ
023203   NOD.Cg-Tg(Itgax-cre)1-1Reiz/PesaJ
005732   NOD.Cg-Tg(Lck-cre)548Jxm/AchJ
023973   NOD.Cg-Tg(Neurog3-cre)1Dam/SbwJ
013251   NOD.FVB-Tg(EIIa-cre)C5379Lmgd/J
008694   NOD/ShiLt-Tg(Foxp3-EGFP/cre)1cJbs/J
004986   NOD/ShiLt-Tg(Ins2-cre)3Lt/LtJ
003855   NOD/ShiLt-Tg(Ins2-cre)5Lt/LtJ
004987   NOD/ShiLt-Tg(Ins2-cre)6Lt/LtJ
012899   STOCK Agrptm1(cre)Lowl/J
026229   STOCK Akap12tm1Ihg Rb1tm2Brn Tg(Pbsn-cre)4Prb/J
012706   STOCK Ccktm1.1(cre)Zjh/J
010910   STOCK Corttm1(cre)Zjh/J
007916   STOCK En1tm2(cre)Wrst/J
008464   STOCK Foxa2tm2.1(cre/Esr1*)Moon/J
010802   STOCK Gad2tm2(cre)Zjh/J
018903   STOCK Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
023407   STOCK HhatTg(TFAP2A-cre)1Will/J
008876   STOCK Hprttm11(Ple176-EGFP/cre)Ems/Mmjax
016879   STOCK Il17atm1.1(icre)Stck/J
024242   STOCK Isl1tm1(cre)Sev/J
018976   STOCK Kdrtm1(cre)Sato/J
017701   STOCK Kiss1tm1.1(cre/EGFP)Stei/J
007022   STOCK Mnx1tm4(cre)Tmj Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
023342   STOCK Myf5tm1(cre/Esr1*)Trdo/J
024713   STOCK Myl1tm1(cre)Sjb/J
014180   STOCK Myocdtm1(cre)Jomm/J
006953   STOCK Notch1tm3(cre)Rko/J
006677   STOCK Olfr151tm28(cre)Mom/MomJ
011103   STOCK Olig2tm2(TVA,cre)Rth/J
010530   STOCK Pax7tm1(cre)Mrc/J
016963   STOCK Slc17a6tm2(cre)Lowl/J
016962   STOCK Slc32a1tm2(cre)Lowl/J
013044   STOCK Ssttm2.1(cre)Zjh/J
012719   STOCK Tgfb3tm1(cre)Vk/J
012620   STOCK Trp53tm1Brd Brca1tm1Aash Tg(LGB-cre)74Acl/J
010908   STOCK Viptm1(cre)Zjh/J
010911   STOCK Wt1tm1(EGFP/cre)Wtp/J
009615   STOCK Tg(Cartpt-cre)1Aibs/J
017336   STOCK Tg(Cd4-cre)1Cwi/BfluJ
005105   STOCK Tg(Chx10-EGFP/cre,-ALPP)2Clc/J
008852   STOCK Tg(En2-cre)22Alj/J
005938   STOCK Tg(Eno2-cre)39Jme/J
011062   STOCK Tg(Gdf9-cre)5092Coo/J
012841   STOCK Tg(Ggt1-cre)M3Egn/J
021207   STOCK Tg(Gnrh1-cre)1Dlc/J
017981   STOCK Tg(Hoxb6-cre)#Mku/J
004692   STOCK Tg(Hoxb7-cre)13Amc/J
014600   STOCK Tg(I12b-cre/ERT2,-ALPP)37Fsh/J
008122   STOCK Tg(Ins2-cre/ERT)1Dam/J
004782   STOCK Tg(KRT14-cre)1Amc/J
005107   STOCK Tg(KRT14-cre/ERT)20Efu/J
008582   STOCK Tg(Kcnc2-Cre)K128Stl/LetJ
023426   STOCK Tg(Kiss1-cre)J2-4Cfe/J
017836   STOCK Tg(LGB-cre)74Acl/J
003551   STOCK Tg(MMTV-cre)1Mam/J
003553   STOCK Tg(MMTV-cre)4Mam/J
009074   STOCK Tg(Myh6-cre)1Jmk/J
005650   STOCK Tg(Myh6-cre/Esr1*)1Jmk/J
009102   STOCK Tg(Nefh-cre)12Kul/J
002858   STOCK Tg(Nes-cre)1Wme/J
002859   STOCK Tg(Nes-cre)2Wme/J
012859   STOCK Tg(Neurog1-cre)1Jejo/J
005667   STOCK Tg(Neurog3-cre)C1Able/J
008119   STOCK Tg(Neurog3-cre/Esr1*)1Dam/J
012462   STOCK Tg(Nr5a1-cre)7Lowl/J
014158   STOCK Tg(Pax4-cre)1Dam/J
024578   STOCK Tg(Pax6-GFP/cre)1Rilm/J
006207   STOCK Tg(Pcp2-cre)1Amc/J
014099   STOCK Tg(Pmch-cre)1Lowl/J
005965   STOCK Tg(Pomc1-cre)16Lowl/J
012452   STOCK Tg(Rr5-GFP/cre)1Sapc/J
006395   STOCK Tg(Sim1-cre)1Lowl/J
009606   STOCK Tg(Six2-EGFP/cre)1Amc/J
019755   STOCK Tg(Six3-cre)69Frty/GcoJ
018147   STOCK Tg(Slc17a8-icre)1Edw/SealJ
012586   STOCK Tg(Slc1a3-cre/ERT)1Nat/J
004783   STOCK Tg(Sox2-cre)1Amc/J
008208   STOCK Tg(Stra8-icre)1Reb/J
016236   STOCK Tg(TCF/Lef1-cre/ERT2)1Dje/J
004746   STOCK Tg(Tagln-cre)1Her/J
012708   STOCK Tg(Thy1-cre/ERT2,-EYFP)HGfng/PyngJ
024240   STOCK Tg(Tnnt2-cre)5Blh/JiaoJ
016584   STOCK Tg(Tph2-icre/ERT2)6Gloss/J
003829   STOCK Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J
008851   STOCK Tg(Wnt1-cre/ERT)1Alj/J
018281   STOCK Tg(Wnt7a-EGFP/cre)#Bhr/Mmjax
008199   STOCK Tg(dlx6a-cre)1Mekk/J
002471   STOCK Tg(hCMV-cre)140Sau/J
023724   STOCK Tg(mI56i-cre,EGFP)1Kc/J
006224   STOCK Tg(tetO-cre)1Jaw/J
View Strains carrying other alleles of cre     (398 strains)

Additional Web Information

Introduction to Cre-lox technology


Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Abdominal Obesity-Metabolic Syndrome 1; AOMS1   (MTTP)
Abetalipoproteinemia; ABL   (MTTP)
Apolipoprotein B; APOB   (APOB)
Hypercholesterolemia, Autosomal Dominant, Type B   (APOB)
Hypercholesterolemia, Familial   (LDLR)
Hypobetalipoproteinemia, Familial, 1; FHBL1   (APOB)
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Research Applications
This mouse can be used to support research in many areas including:

Research Tools
Cre-lox System
      Cre Recombinase Expression
      Cre Recombinase Expression: Inducible
Genetics Research
      Mutagenesis and Transgenesis
      Mutagenesis and Transgenesis: Cre-lox System

cre related

Research Tools
Cre-lox System
Genetics Research
      Mutagenesis and Transgenesis
      Mutagenesis and Transgenesis: Cre-lox System

Apobtm2Sgy related

Cardiovascular Research

Developmental Biology Research
Neural Tube Defects

Neurobiology Research
Neural Tube Defects

Ldlrtm1Her related

Cardiovascular Research

Metabolism Research
Lipid Metabolism

Mttptm2Sgy related

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol Apobtm2Sgy
Allele Name targeted mutation 2, Stephen G Young
Allele Type Targeted (Null/Knockout)
Common Name(s) ApoB48-; ApoB100; ApoB100only; apo-B100;
Mutation Made ByDr. Stephen Young,   Gladstone Institutes UCSF
Strain of Origin129S7/SvEvBrd-Hprt<+>
ES Cell Line NameAB1
ES Cell Line Strain129S7/SvEvBrd-Hprt<+>
Site of ExpressionExpression of the ApoB100 isoform is unaffected by this mutation, while no ApoB48 isoform, which is normally synthesized by the small intestine, is produced from this allele.
Gene Symbol and Name Apob, apolipoprotein B
Chromosome 12
Gene Common Name(s) AI315052; Aa1064; Ac1-060; Apo B-100; ApoB-100; ApoB-48; FLDB; LDLCQ4; expressed sequence AI315052;
General Note Levels of LDL-cholesterol, VLDL, and triglyceride LDL are higher relative to wild-type mice in APOB100 only mice in the presence of wild-type APOE production. In the presence of genetic APOE deficiency, APOB100 only mice have lowered cholesterol levels (J:33830).
Molecular Note A "hit and run"-type vector was used to create a CTA to TTA mutation in codon 2153 in sequences corresponding to the apo-B48 editing codon. Western blot analysis on plasma derived from heterozygous and homozygous mice demostrated that the expression of the ApoB100 isoform is unaffected by this mutation, while no ApoB48 isoform is produced from this allele. [MGI Ref ID J:33830]
Allele Symbol Ldlrtm1Her
Allele Name targeted mutation 1, Joachim Herz
Allele Type Targeted (Null/Knockout)
Common Name(s) LDLR KO; LDLR-; LDLr-KO; LDLr0; LDLrKO; Ldlrtm1Her;
Mutation Made ByDr. Joachim Herz,   Univ of Texas Southwest Med Ctr Dallas
Strain of Origin129S7/SvEvBrd-Hprt<+>
ES Cell Line NameAB1
ES Cell Line Strain129S7/SvEvBrd-Hprt<+>
Site of ExpressionImmunoblot analysis of liver membranes detected a truncated protein in homozygous mutant animals.
Gene Symbol and Name Ldlr, low density lipoprotein receptor
Chromosome 9
Gene Common Name(s) FH; FHC; LDLCQ2; LDLRA;
General Note When used in bone marrow transplant into Ldlrtm1Her homozygous mice, Abca1tm1Jdm Abcg1tm1Dgen homozygous cells accelerate the development of atherosclerosis. (J:130777)
Phenotypic Similarity to Human Syndrome: Type 1 Diabetic Macrovascular Disease (J:174983)
Molecular Note Insertion of a neomycin resistance cassette into exon 4. The authors predict that the targeted allele would encode a truncated non-functional protein that will not bind LDL, and that lacks a membrane spanning segment. Immunoblot analysis of liver membranes detected a truncated protein in homozygous mutant animals. [MGI Ref ID J:37394]
Allele Symbol Mttptm2Sgy
Allele Name targeted mutation 2, Steven G Young
Allele Type Targeted (Conditional ready (e.g. floxed), No functional change)
Common Name(s) Mttpfl;
Mutation Made ByDr. Stephen Young,   Gladstone Institutes UCSF
Strain of Origin129S4/SvJae
ES Cell Line NameJ1
ES Cell Line Strain129S4/SvJae
Site of Expressioncre mutation deletes floxed Mttp gene, reversing hypercholesterolemia phenotype
Gene Symbol and Name Mttp, microsomal triglyceride transfer protein
Chromosome 3
Gene Common Name(s) 1810043K16Rik; ABL; MTP; RIKEN cDNA 1810043K16 gene;
Molecular Note A neomycin resistance cassette flanked by loxP sites was inserted into intron 1. An additional loxP site was inserted 2.5 kb upstream of the promoter and exon 1. [MGI Ref ID J:54612]
Allele Symbol Tg(Mx1-cre)1Cgn
Allele Name transgene insertion 1, University of Cologne
Allele Type Transgenic (Inducible, cre- or Flp-expressing)
Common Name(s) Mx-Cre; Mx-Cre 31; Mx1-Cre; Mx1cre; MxCre; MxCreTg; Tg(Mx1-cre)hemi;
Mutation Made ByDr. Ralf Kuhn,   University of Cologne
Strain of Origin(C57BL/6 x CBA)F2
Site of Expressionwidespread pattern of expression; promoter induced to high levels of transcription by administration of interferon alpha, interferon beta, or synthetic double-stranded RNA; provides capability to induce the "knockout" at any time during development
Expressed Gene cre, cre recombinase, bacteriophage P1
Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence.
Promoter Mx1, MX dynamin-like GTPase 1, mouse, laboratory
Driver Note Mx1
Inducible Note Induced by interferon (-alpha or -beta) or polyinosinic-polycytidylic acid (pI:pC).
Molecular Note This transgene expresses Cre recombinase under the control of an inducible Mx1 promoter, which is silent in healthy mice, and active in the liver and in lymphocytes after induction with IFN or pI-pC. The construct also contains a 2.1 kb fragment from thehuman growth hormone gene. [MGI Ref ID J:67927]


Genotyping Information

Genotyping Protocols

Apobtm2SgyEP, End Point Analysis
Generic Cre Melt Curve Analysis, MELT
Generic Cre Melt Curve Analysis, Probe
Generic Cre Quantitative PCR, QPCR
Ldlrtm1Her-alternate 1, High Resolution Melting
Mttptm2Sgy, Standard PCR
Apobtm2Sgy, Restriction Enzyme Digest

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Selected Reference(s)

Veniant MM; Withycombe S; Young SG. 2001. Lipoprotein size and atherosclerosis susceptibility in Apoe(-/-) and Ldlr(-/-) mice. Arterioscler Thromb Vasc Biol 21(10):1567-70. [PubMed: 11597927]  [MGI Ref ID J:109864]

Additional References

Lieu HD; Withycombe SK; Walker Q; Rong JX; Walzem RL; Wong JS; Hamilton RL; Fisher EA; Young SG. 2003. Eliminating atherogenesis in mice by switching off hepatic lipoprotein secretion. Circulation 107(9):1315-21. [PubMed: 12628954]  [MGI Ref ID J:91722]

Apobtm2Sgy related

Alger HM; Brown JM; Sawyer JK; Kelley KL; Shah R; Wilson MD; Willingham MC; Rudel LL. 2010. Inhibition of acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) prevents dietary cholesterol-associated steatosis by enhancing hepatic triglyceride mobilization. J Biol Chem 285(19):14267-74. [PubMed: 20231283]  [MGI Ref ID J:162960]

Anant S; Murmu N; Houchen CW; Mukhopadhyay D; Riehl TE; Young SG; Morrison AR; Stenson WF; Davidson NO. 2004. Apobec-1 protects intestine from radiation injury through posttranscriptional regulation of cyclooxygenase-2 expression. Gastroenterology 127(4):1139-49. [PubMed: 15480992]  [MGI Ref ID J:93425]

Baeyens N; Mulligan-Kehoe MJ; Corti F; Simon DD; Ross TD; Rhodes JM; Wang TZ; Mejean CO; Simons M; Humphrey J; Schwartz MA. 2014. Syndecan 4 is required for endothelial alignment in flow and atheroprotective signaling. Proc Natl Acad Sci U S A 111(48):17308-13. [PubMed: 25404299]  [MGI Ref ID J:216650]

Bell TA 3rd; Kelley K; Wilson MD; Sawyer JK; Rudel LL. 2007. Dietary fat-induced alterations in atherosclerosis are abolished by ACAT2-deficiency in ApoB100 only, LDLr-/- mice. Arterioscler Thromb Vasc Biol 27(6):1396-402. [PubMed: 17431188]  [MGI Ref ID J:134910]

Bjorkegren JL; Hagg S; Talukdar HA; Foroughi Asl H; Jain RK; Cedergren C; Shang MM; Rossignoli A; Takolander R; Melander O; Hamsten A; Michoel T; Skogsberg J. 2014. Plasma cholesterol-induced lesion networks activated before regression of early, mature, and advanced atherosclerosis. PLoS Genet 10(2):e1004201. [PubMed: 24586211]  [MGI Ref ID J:211003]

Bretillon L; Acar N; Seeliger MW; Santos M; Maire MA; Juaneda P; Martine L; Gregoire S; Joffre C; Bron AM; Creuzot-Garcher C. 2008. ApoB100,LDLR-/- mice exhibit reduced electroretinographic response and cholesteryl esters deposits in the retina. Invest Ophthalmol Vis Sci 49(4):1307-14. [PubMed: 18385042]  [MGI Ref ID J:136142]

Brown JM; Chung S; Sawyer JK; Degirolamo C; Alger HM; Nguyen T; Zhu X; Duong MN; Wibley AL; Shah R; Davis MA; Kelley K; Wilson MD; Kent C; Parks JS; Rudel LL. 2008. Inhibition of stearoyl-coenzyme A desaturase 1 dissociates insulin resistance and obesity from atherosclerosis. Circulation 118(14):1467-75. [PubMed: 18794388]  [MGI Ref ID J:158044]

Brown JM; Chung S; Sawyer JK; Degirolamo C; Alger HM; Nguyen TM; Zhu X; Duong MN; Brown AL; Lord C; Shah R; Davis MA; Kelley K; Wilson MD; Madenspacher J; Fessler MB; Parks JS; Rudel LL. 2010. Combined therapy of dietary fish oil and stearoyl-CoA desaturase 1 inhibition prevents the metabolic syndrome and atherosclerosis. Arterioscler Thromb Vasc Biol 30(1):24-30. [PubMed: 19834103]  [MGI Ref ID J:171803]

Conde-Knape K; Okada K; Ramakrishnan R; Shachter NS. 2004. Overexpression of apoC-III produces lesser hypertriglyceridemia in apoB-48-only gene-targeted mice than in apoB-100-only mice. J Lipid Res 45(12):2235-44. [PubMed: 15342689]  [MGI Ref ID J:94159]

Degrace P; Moindrot B; Mohamed I; Gresti J; Du ZY; Chardigny JM; Sebedio JL; Clouet P. 2006. Upregulation of liver VLDL receptor and FAT/CD36 expression in LDLR-/- apoB100/100 mice fed trans-10,cis-12 conjugated linoleic acid. J Lipid Res 47(12):2647-55. [PubMed: 16957181]  [MGI Ref ID J:117203]

Farese RVJr; Veniant MM; Cham CM; Flynn LM; Pierotti V; Loring JF; Traber M; Ruland S; Stokowski RS; Huszar D; Young SG. 1996. Phenotypic analysis of mice expressing exclusively apolipoprotein B48 or apolipoprotein B100. Proc Natl Acad Sci U S A 93(13):6393-8. [PubMed: 8692825]  [MGI Ref ID J:33830]

Feig JE; Parathath S; Rong JX; Mick SL; Vengrenyuk Y; Grauer L; Young SG; Fisher EA. 2011. Reversal of hyperlipidemia with a genetic switch favorably affects the content and inflammatory state of macrophages in atherosclerotic plaques. Circulation 123(9):989-98. [PubMed: 21339485]  [MGI Ref ID J:183750]

Gonzales JC; Gordts PL; Foley EM; Esko JD. 2013. Apolipoproteins E and AV mediate lipoprotein clearance by hepatic proteoglycans. J Clin Invest 123(6):2742-51. [PubMed: 23676495]  [MGI Ref ID J:201440]

Heinonen SE; Leppanen P; Kholova I; Lumivuori H; Hakkinen SK; Bosch F; Laakso M; Yla-Herttuala S. 2007. Increased atherosclerotic lesion calcification in a novel mouse model combining insulin resistance, hyperglycemia, and hypercholesterolemia. Circ Res 101(10):1058-67. [PubMed: 17872464]  [MGI Ref ID J:141333]

Hinder LM; Vincent AM; Hayes JM; McLean LL; Feldman EL. 2013. Apolipoprotein E knockout as the basis for mouse models of dyslipidemia-induced neuropathy. Exp Neurol 239:102-10. [PubMed: 23059459]  [MGI Ref ID J:196993]

Iqbal J; Rudel LL; Hussain MM. 2008. Microsomal triglyceride transfer protein enhances cellular cholesteryl esterification by relieving product inhibition. J Biol Chem 283(29):19967-80. [PubMed: 18502767]  [MGI Ref ID J:138737]

Kim E; Ambroziak P; Veniant MM; Hamilton RL; Young SG. 1998. A gene-targeted mouse model for familial hypobetalipoproteinemia. Low levels of apolipoprotein B mRNA in association with a nonsense mutation in exon 26 of the apolipoprotein B gene. J Biol Chem 273(51):33977-84. [PubMed: 9852051]  [MGI Ref ID J:51549]

Kim E; Cham CM; Veniant MM; Ambroziak P; Young SG. 1998. Dual mechanisms for the low plasma levels of truncated apolipoprotein B proteins in familial hypobetalipoproteinemia. Analysis of a new mouse model with a nonsense mutation in the Apob gene. J Clin Invest 101(6):1468-77. [PubMed: 9502790]  [MGI Ref ID J:46549]

Kinnunen K; Heinonen SE; Kalesnykas G; Laidinen S; Uusitalo-Jarvinen H; Uusitalo H; Yla-Herttuala S. 2013. LDLR-/-ApoB100/100 mice with insulin-like growth factor II overexpression reveal a novel form of retinopathy with photoreceptor atrophy and altered morphology of the retina. Mol Vis 19:1723-33. [PubMed: 23922490]  [MGI Ref ID J:205300]

Kovacs A; Tornvall P; Nilsson R; Tegner J; Hamsten A; Bjorkegren J. 2007. Human C-reactive protein slows atherosclerosis development in a mouse model with human-like hypercholesterolemia. Proc Natl Acad Sci U S A 104(34):13768-73. [PubMed: 17702862]  [MGI Ref ID J:124095]

Lieu HD; Withycombe SK; Walker Q; Rong JX; Walzem RL; Wong JS; Hamilton RL; Fisher EA; Young SG. 2003. Eliminating atherogenesis in mice by switching off hepatic lipoprotein secretion. Circulation 107(9):1315-21. [PubMed: 12628954]  [MGI Ref ID J:91722]

Lloyd DJ; Helmering J; Kaufman SA; Turk J; Silva M; Vasquez S; Weinstein D; Johnston B; Hale C; Veniant MM. 2011. A Volumetric Method for Quantifying Atherosclerosis in Mice by Using MicroCT: Comparison to En Face. PLoS One 6(4):e18800. [PubMed: 21533112]  [MGI Ref ID J:172393]

Lloyd DJ; McCormick J; Helmering J; Kim KW; Wang M; Fordstrom P; Kaufman SA; Lindberg RA; Veniant MM. 2008. Generation and characterization of two novel mouse models exhibiting the phenotypes of the metabolic syndrome: Apob48-/-Lepob/ob mice devoid of ApoE or Ldlr. Am J Physiol Endocrinol Metab 294(3):E496-505. [PubMed: 18160459]  [MGI Ref ID J:133453]

Lu X; Xia M; Endresz V; Faludi I; Mundkur L; Gonczol E; Chen D; Kakkar VV. 2012. Immunization with a combination of 2 peptides derived from the C5a receptor significantly reduces early atherosclerotic lesion in Ldlr(tm1Her) Apob(tm2Sgy) J mice. Arterioscler Thromb Vasc Biol 32(10):2358-71. [PubMed: 22837469]  [MGI Ref ID J:207883]

Melchior JT; Sawyer JK; Kelley KL; Shah R; Wilson MD; Hantgan RR; Rudel LL. 2013. LDL particle core enrichment in cholesteryl oleate increases proteoglycan binding and promotes atherosclerosis. J Lipid Res 54(9):2495-503. [PubMed: 23804810]  [MGI Ref ID J:200774]

Miller JD; Chu Y; Castaneda LE; Serrano KM; Brooks RM; Heistad DD. 2013. Vascular function during prolonged progression and regression of atherosclerosis in mice. Arterioscler Thromb Vasc Biol 33(3):459-65. [PubMed: 23307875]  [MGI Ref ID J:216887]

Miller JD; Weiss RM; Serrano KM; Brooks RM 2nd; Berry CJ; Zimmerman K; Young SG; Heistad DD. 2009. Lowering plasma cholesterol levels halts progression of aortic valve disease in mice. Circulation 119(20):2693-701. [PubMed: 19433756]  [MGI Ref ID J:166428]

Mollmark J; Ravi S; Sun B; Shipman S; Buitendijk M; Simons M; Mulligan-Kehoe MJ. 2011. Antiangiogenic activity of rPAI-1(23) promotes vasa vasorum regression in hypercholesterolemic mice through a plasmin-dependent mechanism. Circ Res 108(12):1419-28. [PubMed: 21546607]  [MGI Ref ID J:185688]

Mollmark JI; Park AJ; Kim J; Wang TZ; Katzenell S; Shipman SL; Zagorchev LG; Simons M; Mulligan-Kehoe MJ. 2012. Fibroblast growth factor-2 is required for vasa vasorum plexus stability in hypercholesterolemic mice. Arterioscler Thromb Vasc Biol 32(11):2644-51. [PubMed: 22982464]  [MGI Ref ID J:207880]

Mundkur L; Mukhopadhyay R; Samson S; Varma M; Kale D; Chen D; Shivaprasad S; Sivanandan H; Soman V; Lu X; Kakkar VV. 2013. Mucosal tolerance to a combination of ApoB and HSP60 peptides controls plaque progression and stabilizes vulnerable plaque in Apob(tm2Sgy)Ldlr(tm1Her)/J mice. PLoS One 8(3):e58364. [PubMed: 23505495]  [MGI Ref ID J:199840]

Parathath S; Grauer L; Huang LS; Sanson M; Distel E; Goldberg IJ; Fisher EA. 2011. Diabetes adversely affects macrophages during atherosclerotic plaque regression in mice. Diabetes 60(6):1759-69. [PubMed: 21562077]  [MGI Ref ID J:177946]

Ramsey SA; Vengrenyuk Y; Menon P; Podolsky I; Feig JE; Aderem A; Fisher EA; Gold ES. 2014. Epigenome-guided analysis of the transcriptome of plaque macrophages during atherosclerosis regression reveals activation of the Wnt signaling pathway. PLoS Genet 10(12):e1004828. [PubMed: 25474352]  [MGI Ref ID J:222183]

Robbins CS; Chudnovskiy A; Rauch PJ; Figueiredo JL; Iwamoto Y; Gorbatov R; Etzrodt M; Weber GF; Ueno T; van Rooijen N; Mulligan-Kehoe MJ; Libby P; Nahrendorf M; Pittet MJ; Weissleder R; Swirski FK. 2012. Extramedullary hematopoiesis generates Ly-6C(high) monocytes that infiltrate atherosclerotic lesions. Circulation 125(2):364-74. [PubMed: 22144566]  [MGI Ref ID J:193795]

Silvola JM; Saraste A; Forsback S; Laine VJ; Saukko P; Heinonen SE; Yla-Herttuala S; Roivainen A; Knuuti J. 2011. Detection of hypoxia by [18F]EF5 in atherosclerotic plaques in mice. Arterioscler Thromb Vasc Biol 31(5):1011-5. [PubMed: 21372297]  [MGI Ref ID J:191482]

Skogsberg J; Dicker A; Ryden M; Astrom G; Nilsson R; Bhuiyan H; Vitols S; Mairal A; Langin D; Alberts P; Walum E; Tegner J; Hamsten A; Arner P; Bjorkegren J. 2008. ApoB100-LDL acts as a metabolic signal from liver to peripheral fat causing inhibition of lipolysis in adipocytes. PLoS ONE 3(11):e3771. [PubMed: 19020660]  [MGI Ref ID J:143905]

Skogsberg J; Lundstrom J; Kovacs A; Nilsson R; Noori P; Maleki S; Kohler M; Hamsten A; Tegner J; Bjorkegren J. 2008. Transcriptional profiling uncovers a network of cholesterol-responsive atherosclerosis target genes. PLoS Genet 4(3):e1000036. [PubMed: 18369455]  [MGI Ref ID J:136835]

Veniant MM; Pierotti V; Newland D; Cham CM; Sanan DA; Walzem RL ; Young SG. 1997. Susceptibility to atherosclerosis in mice expressing exclusively apolipoprotein B48 or apolipoprotein B100. J Clin Invest 100(1):180-8. [PubMed: 9202070]  [MGI Ref ID J:41510]

Veniant MM; Sullivan MA; Kim SK; Ambroziak P; Chu A; Wilson MD; Hellerstein MK; Rudel LL; Walzem RL; Young SG. 2000. Defining the atherogenicity of large and small lipoproteins containing apolipoprotein B100 J Clin Invest 106(12):1501-10. [PubMed: 11120757]  [MGI Ref ID J:66424]

Veniant MM; Zlot CH; Walzem RL; Pierotti V; Driscoll R; Dichek D ; Herz J ; Young SG. 1998. Lipoprotein clearance mechanisms in LDL receptor-deficient Apo-B48-only and Apo-B100-only mice. J Clin Invest 102(8):1559-68. [PubMed: 9788969]  [MGI Ref ID J:51022]

Weinstein MM; Yin L; Tu Y; Wang X; Wu X; Castellani LW; Walzem RL; Lusis AJ; Fong LG; Beigneux AP; Young SG. 2010. Chylomicronemia elicits atherosclerosis in mice--brief report. Arterioscler Thromb Vasc Biol 30(1):20-3. [PubMed: 19815815]  [MGI Ref ID J:171805]

Xia M; Chen D; Endresz V; Faludi I; Szabo A; Gonczol E; Kakkar V; Lu X. 2013. Immunization of Chlamydia pneumoniae (Cpn)-infected Apob(tm2Sgy)Ldlr(tm1Her)/J mice with a combined peptide of Cpn significantly reduces atherosclerotic lesion development. PLoS One 8(12):e81056. [PubMed: 24349031]  [MGI Ref ID J:211155]

Xie Y; Blanc V; Kerr TA; Kennedy S; Luo J; Newberry EP; Davidson NO. 2009. Decreased Expression of Cholesterol 7{alpha}-Hydroxylase and Altered Bile Acid Metabolism in Apobec-1-/- Mice Lead to Increased Gallstone Susceptibility. J Biol Chem 284(25):16860-71. [PubMed: 19386592]  [MGI Ref ID J:151211]

Ldlrtm1Her related

Accad M; Smith SJ; Newland DL; Sanan DA; King LE Jr; Linton MF; Fazio S; Farese RV Jr. 2000. Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1 [see comments] J Clin Invest 105(6):711-9. [PubMed: 10727439]  [MGI Ref ID J:61147]

Adachi H; Kondo T; Koh GY; Nagy A; Oike Y; Araki E. 2011. Angptl4 deficiency decreases serum triglyceride levels in low-density lipoprotein receptor knockout mice and streptozotocin-induced diabetic mice. Biochem Biophys Res Commun 409(2):177-80. [PubMed: 21549101]  [MGI Ref ID J:172599]

Afek A; Keren G; Harats D; George J. 2001. Whole body hyperthermia accelerates atherogenesis in low-density lipoprotein receptor deficient mice. Exp Mol Pathol 71(1):63-72. [PubMed: 11502098]  [MGI Ref ID J:106255]

Ahmad PJ; Trcka D; Xue S; Franco C; Speer MY; Giachelli CM; Bendeck MP. 2009. Discoidin domain receptor-1 deficiency attenuates atherosclerotic calcification and smooth muscle cell-mediated mineralization. Am J Pathol 175(6):2686-96. [PubMed: 19893047]  [MGI Ref ID J:155320]

Ait-Oufella H; Herbin O; Lahoute C; Coatrieux C; Loyer X; Joffre J; Laurans L; Ramkhelawon B; Blanc-Brude O; Karabina S; Girard CA; Payre C; Yamamoto K; Binder CJ; Murakami M; Tedgui A; Lambeau G; Mallat Z. 2013. Group X secreted phospholipase A2 limits the development of atherosclerosis in LDL receptor-null mice. Arterioscler Thromb Vasc Biol 33(3):466-73. [PubMed: 23349189]  [MGI Ref ID J:216884]

Ait-Oufella H; Kinugawa K; Zoll J; Simon T; Boddaert J; Heeneman S; Blanc-Brude O; Barateau V; Potteaux S; Merval R; Esposito B; Teissier E; Daemen MJ; Leseche G; Boulanger C; Tedgui A; Mallat Z. 2007. Lactadherin deficiency leads to apoptotic cell accumulation and accelerated atherosclerosis in mice. Circulation 115(16):2168-77. [PubMed: 17420351]  [MGI Ref ID J:135906]

Ait-Oufella H; Pouresmail V; Simon T; Blanc-Brude O; Kinugawa K; Merval R; Offenstadt G; Leseche G; Cohen PL; Tedgui A; Mallat Z. 2008. Defective mer receptor tyrosine kinase signaling in bone marrow cells promotes apoptotic cell accumulation and accelerates atherosclerosis. Arterioscler Thromb Vasc Biol 28(8):1429-31. [PubMed: 18467644]  [MGI Ref ID J:159811]

Ait-Oufella H; Salomon BL; Potteaux S; Robertson AK; Gourdy P; Zoll J; Merval R; Esposito B; Cohen JL; Fisson S; Flavell RA; Hansson GK; Klatzmann D; Tedgui A; Mallat Z. 2006. Natural regulatory T cells control the development of atherosclerosis in mice. Nat Med 12(2):178-80. [PubMed: 16462800]  [MGI Ref ID J:105800]

Albrecht C; Preusch MR; Hofmann G; Morris-Rosenfeld S; Blessing E; Rosenfeld ME; Katus HA; Bea F. 2010. Egr-1 deficiency in bone marrow-derived cells reduces atherosclerotic lesion formation in a hyperlipidaemic mouse model. Cardiovasc Res 86(2):321-9. [PubMed: 20110335]  [MGI Ref ID J:175882]

Alger HM; Brown JM; Sawyer JK; Kelley KL; Shah R; Wilson MD; Willingham MC; Rudel LL. 2010. Inhibition of acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) prevents dietary cholesterol-associated steatosis by enhancing hepatic triglyceride mobilization. J Biol Chem 285(19):14267-74. [PubMed: 20231283]  [MGI Ref ID J:162960]

Allred KF; Smart EJ; Wilson ME. 2006. Estrogen receptor-alpha mediates gender differences in atherosclerosis induced by HIV protease inhibitors. J Biol Chem 281(3):1419-25. [PubMed: 16299001]  [MGI Ref ID J:107322]

Altenburg M; Arbones-Mainar J; Johnson L; Wilder J; Maeda N. 2008. Human LDL receptor enhances sequestration of ApoE4 and VLDL remnants on the surface of hepatocytes but not their internalization in mice. Arterioscler Thromb Vasc Biol 28(6):1104-10. [PubMed: 18369154]  [MGI Ref ID J:149026]

Angeli V; Llodra J; Rong JX; Satoh K; Ishii S; Shimizu T; Fisher EA; Randolph GJ. 2004. Dyslipidemia associated with atherosclerotic disease systemically alters dendritic cell mobilization. Immunity 21(4):561-74. [PubMed: 15485633]  [MGI Ref ID J:93917]

Anggraeni VY; Emoto N; Yagi K; Mayasari DS; Nakayama K; Izumikawa T; Kitagawa H; Hirata K. 2011. Correlation of C4ST-1 and ChGn-2 expression with chondroitin sulfate chain elongation in atherosclerosis. Biochem Biophys Res Commun 406(1):36-41. [PubMed: 21284936]  [MGI Ref ID J:170936]

Arai S; Shelton JM; Chen M; Bradley MN; Castrillo A; Bookout AL; Mak PA; Edwards PA; Mangelsdorf DJ; Tontonoz P; Miyazaki T. 2005. A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development. Cell Metab 1(3):201-13. [PubMed: 16054063]  [MGI Ref ID J:129845]

Aslanian AM; Chapman HA; Charo IF. 2005. Transient role for CD1d-restricted natural killer T cells in the formation of atherosclerotic lesions. Arterioscler Thromb Vasc Biol 25(3):628-32. [PubMed: 15591216]  [MGI Ref ID J:110061]

Aslanian AM; Charo IF. 2006. Targeted disruption of the scavenger receptor and chemokine CXCL16 accelerates atherosclerosis. Circulation 114(6):583-90. [PubMed: 16880330]  [MGI Ref ID J:123851]

Ason B; van der Hoorn JW; Chan J; Lee E; Pieterman EJ; Nguyen KK; Di M; Shetterly S; Tang J; Yeh WC; Schwarz M; Jukema JW; Scott R; Wasserman SM; Princen HM; Jackson S. 2014. PCSK9 inhibition fails to alter hepatic LDLR, circulating cholesterol, and atherosclerosis in the absence of ApoE. J Lipid Res 55(11):2370-9. [PubMed: 25258384]  [MGI Ref ID J:216603]

Asterholm IW; Rutkowski JM; Fujikawa T; Cho YR; Fukuda M; Tao C; Wang ZV; Gupta RK; Elmquist JK; Scherer PE. 2014. Elevated resistin levels induce central leptin resistance and increased atherosclerotic progression in mice. Diabetologia 57(6):1209-18. [PubMed: 24623101]  [MGI Ref ID J:210884]

Avraham-Davidi I; Ely Y; Pham VN; Castranova D; Grunspan M; Malkinson G; Gibbs-Bar L; Mayseless O; Allmog G; Lo B; Warren CM; Chen TT; Ungos J; Kidd K; Shaw K; Rogachev I; Wan W; Murphy PM; Farber SA; Carmel L; Shelness GS; Iruela-Arispe ML; Weinstein BM; Yaniv K. 2012. ApoB-containing lipoproteins regulate angiogenesis by modulating expression of VEGF receptor 1. Nat Med 18(6):967-73. [PubMed: 22581286]  [MGI Ref ID J:187459]

Azhar S; Luo Y; Medicherla S; Reaven E. 1999. Upregulation of selective cholesteryl ester uptake pathway in mice with deletion of low-density lipoprotein receptor function. J Cell Physiol 180(2):190-202. [PubMed: 10395289]  [MGI Ref ID J:56099]

Babaev VR; Chew JD; Ding L; Davis S; Breyer MD; Breyer RM; Oates JA; Fazio S; Linton MF. 2008. Macrophage EP4 deficiency increases apoptosis and suppresses early atherosclerosis. Cell Metab 8(6):492-501. [PubMed: 19041765]  [MGI Ref ID J:144376]

Babaev VR; Ding L; Reese J; Morrow JD; Breyer MD; Dey SK; Fazio S; Linton MF. 2006. Cyclooxygenase-1 deficiency in bone marrow cells increases early atherosclerosis in apolipoprotein E- and low-density lipoprotein receptor-null mice. Circulation 113(1):108-17. [PubMed: 16380543]  [MGI Ref ID J:121507]

Babaev VR; Hebron KE; Wiese CB; Toth CL; Ding L; Zhang Y; May JM; Fazio S; Vickers KC; Linton MF. 2014. Macrophage deficiency of Akt2 reduces atherosclerosis in Ldlr null mice. J Lipid Res 55(11):2296-308. [PubMed: 25240046]  [MGI Ref ID J:216614]

Babaev VR; Ishiguro H; Ding L; Yancey PG; Dove DE; Kovacs WJ; Semenkovich CF; Fazio S; Linton MF. 2007. Macrophage expression of peroxisome proliferator-activated receptor-alpha reduces atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation 116(12):1404-12. [PubMed: 17724261]  [MGI Ref ID J:139843]

Babaev VR; Yancey PG; Ryzhov SV; Kon V; Breyer MD; Magnuson MA; Fazio S; Linton MF. 2005. Conditional knockout of macrophage PPARgamma increases atherosclerosis in C57BL/6 and low-density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol 25(8):1647-53. [PubMed: 15947238]  [MGI Ref ID J:114332]

Baeyens N; Mulligan-Kehoe MJ; Corti F; Simon DD; Ross TD; Rhodes JM; Wang TZ; Mejean CO; Simons M; Humphrey J; Schwartz MA. 2014. Syndecan 4 is required for endothelial alignment in flow and atheroprotective signaling. Proc Natl Acad Sci U S A 111(48):17308-13. [PubMed: 25404299]  [MGI Ref ID J:216650]

Baldan A; Pei L; Lee R; Tarr P; Tangirala RK; Weinstein MM; Frank J; Li AC; Tontonoz P; Edwards PA. 2006. Impaired development of atherosclerosis in hyperlipidemic Ldlr-/- and ApoE-/- mice transplanted with Abcg1-/- bone marrow. Arterioscler Thromb Vasc Biol 26(10):2301-7. [PubMed: 16888235]  [MGI Ref ID J:128048]

Banko NS; McAlpine CS; Venegas-Pino DE; Raja P; Shi Y; Khan MI; Werstuck GH. 2014. Glycogen synthase kinase 3alpha deficiency attenuates atherosclerosis and hepatic steatosis in high fat diet-fed low density lipoprotein receptor-deficient mice. Am J Pathol 184(12):3394-404. [PubMed: 25451156]  [MGI Ref ID J:218258]

Barish GD; Yu RT; Karunasiri MS; Becerra D; Kim J; Tseng TW; Tai LJ; Leblanc M; Diehl C; Cerchietti L; Miller YI; Witztum JL; Melnick AM; Dent AL; Tangirala RK; Evans RM. 2012. The Bcl6-SMRT/NCoR cistrome represses inflammation to attenuate atherosclerosis. Cell Metab 15(4):554-62. [PubMed: 22465074]  [MGI Ref ID J:184208]

Barlic J; Murphy PM. 2007. Chemokine regulation of atherosclerosis. J Leukoc Biol 82(2):226-36. [PubMed: 17329566]  [MGI Ref ID J:123530]

Bartelt A; Bruns OT; Reimer R; Hohenberg H; Ittrich H; Peldschus K; Kaul MG; Tromsdorf UI; Weller H; Waurisch C; Eychmuller A; Gordts PL; Rinninger F; Bruegelmann K; Freund B; Nielsen P; Merkel M; Heeren J. 2011. Brown adipose tissue activity controls triglyceride clearance. Nat Med 17(2):200-5. [PubMed: 21258337]  [MGI Ref ID J:168555]

Barthwal MK; Anzinger JJ; Xu Q; Bohnacker T; Wymann MP; Kruth HS. 2013. Fluid-phase pinocytosis of native low density lipoprotein promotes murine M-CSF differentiated macrophage foam cell formation. PLoS One 8(3):e58054. [PubMed: 23536783]  [MGI Ref ID J:199527]

Bassett CM; Edel AL; Patenaude AF; McCullough RS; Blackwood DP; Chouinard PY; Paquin P; Lamarche B; Pierce GN. 2010. Dietary vaccenic acid has antiatherogenic effects in LDLr-/- mice. J Nutr 140(1):18-24. [PubMed: 19923390]  [MGI Ref ID J:155556]

Basso F; Amar MJ; Wagner EM; Vaisman B; Paigen B; Santamarina-Fojo S; Remaley AT. 2006. Enhanced ABCG1 expression increases atherosclerosis in LDLr-KO mice on a western diet. Biochem Biophys Res Commun 351(2):398-404. [PubMed: 17070501]  [MGI Ref ID J:116554]

Basso F; Freeman LA; Ko C; Joyce C; Amar MJ; Shamburek RD; Tansey T; Thomas F; Wu J; Paigen B; Remaley AT; Santamarina-Fojo S; Brewer HB Jr. 2007. Hepatic ABCG5/G8 overexpression reduces apoB-lipoproteins and atherosclerosis when cholesterol absorption is inhibited. J Lipid Res 48(1):114-26. [PubMed: 17060690]  [MGI Ref ID J:117682]

Bavendiek U; Zirlik A; LaClair S; MacFarlane L; Libby P; Schonbeck U. 2005. Atherogenesis in mice does not require CD40 ligand from bone marrow-derived cells. Arterioscler Thromb Vasc Biol 25(6):1244-9. [PubMed: 15746436]  [MGI Ref ID J:114293]

Becker L; Liu NC; Averill MM; Yuan W; Pamir N; Peng Y; Irwin AD; Fu X; Bornfeldt KE; Heinecke JW. 2012. Unique proteomic signatures distinguish macrophages and dendritic cells. PLoS One 7(3):e33297. [PubMed: 22428014]  [MGI Ref ID J:186914]

Becker M; Rabe K; Lebherz C; Zugwurst J; Goke B; Parhofer KG; Lehrke M; Broedl UC. 2010. Expression of human chemerin induces insulin resistance in the skeletal muscle but does not affect weight, lipid levels, and atherosclerosis in LDL receptor knockout mice on high-fat diet. Diabetes 59(11):2898-903. [PubMed: 20724582]  [MGI Ref ID J:169337]

Bell TA 3rd; Kelley K; Wilson MD; Sawyer JK; Rudel LL. 2007. Dietary fat-induced alterations in atherosclerosis are abolished by ACAT2-deficiency in ApoB100 only, LDLr-/- mice. Arterioscler Thromb Vasc Biol 27(6):1396-402. [PubMed: 17431188]  [MGI Ref ID J:134910]

Bernal-Mizrachi C; Weng S; Feng C; Finck BN; Knutsen RH; Leone TC; Coleman T; Mecham RP; Kelly DP; Semenkovich CF. 2003. Dexamethasone induction of hypertension and diabetes is PPAR-alpha dependent in LDL receptor-null mice. Nat Med 9(8):1069-75. [PubMed: 12847522]  [MGI Ref ID J:84844]

Bernhagen J; Krohn R; Lue H; Gregory JL; Zernecke A; Koenen RR; Dewor M; Georgiev I; Schober A; Leng L; Kooistra T; Fingerle-Rowson G; Ghezzi P; Kleemann R; McColl SR; Bucala R; Hickey MJ; Weber C. 2007. MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment. Nat Med 13(5):587-596. [PubMed: 17435771]  [MGI Ref ID J:121807]

Bhasin KK; van Nas A; Martin LJ; Davis RC; Devaskar SU; Lusis AJ. 2009. Maternal low-protein diet or hypercholesterolemia reduces circulating essential amino acids and leads to intrauterine growth restriction. Diabetes 58(3):559-66. [PubMed: 19073773]  [MGI Ref ID J:146932]

Bhatia VK; Yun S; Leung V; Grimsditch DC; Benson GM; Botto MB; Boyle JJ; Haskard DO. 2007. Complement C1q reduces early atherosclerosis in low-density lipoprotein receptor-deficient mice. Am J Pathol 170(1):416-26. [PubMed: 17200212]  [MGI Ref ID J:117210]

Bi X; Zhu X; Duong M; Boudyguina EY; Wilson MD; Gebre AK; Parks JS. 2013. Liver ABCA1 deletion in LDLrKO mice does not impair macrophage reverse cholesterol transport or exacerbate atherogenesis. Arterioscler Thromb Vasc Biol 33(10):2288-96. [PubMed: 23814116]  [MGI Ref ID J:222231]

Bie J; Wang J; Marqueen KE; Osborne R; Kakiyama G; Korzun W; Ghosh SS; Ghosh S. 2013. Liver-specific cholesteryl ester hydrolase deficiency attenuates sterol elimination in the feces and increases atherosclerosis in ldlr-/- mice. Arterioscler Thromb Vasc Biol 33(8):1795-802. [PubMed: 23744992]  [MGI Ref ID J:221021]

Bie J; Wang J; Yuan Q; Kakiyama G; Ghosh SS; Ghosh S. 2014. Liver-specific transgenic expression of cholesteryl ester hydrolase reduces atherosclerosis in Ldlr-/- mice. J Lipid Res 55(4):729-38. [PubMed: 24563511]  [MGI Ref ID J:208896]

Bie J; Zhao B; Ghosh S. 2011. Atherosclerotic lesion progression is attenuated by reconstitution with bone marrow from macrophage-specific cholesteryl ester hydrolase transgenic mice. Am J Physiol Regul Integr Comp Physiol 301(4):R967-74. [PubMed: 21795638]  [MGI Ref ID J:178811]

Bie J; Zhao B; Song J; Ghosh S. 2010. Improved insulin sensitivity in high fat- and high cholesterol-fed Ldlr-/- mice with macrophage-specific transgenic expression of cholesteryl ester hydrolase: role of macrophage inflammation and infiltration into adipose tissue. J Biol Chem 285(18):13630-7. [PubMed: 20189995]  [MGI Ref ID J:163056]

Bieghs V; Van Gorp PJ; Wouters K; Hendrikx T; Gijbels MJ; van Bilsen M; Bakker J; Binder CJ; Lutjohann D; Staels B; Hofker MH; Shiri-Sverdlov R. 2012. LDL receptor knock-out mice are a physiological model particularly vulnerable to study the onset of inflammation in non-alcoholic fatty liver disease. PLoS One 7(1):e30668. [PubMed: 22295101]  [MGI Ref ID J:184219]

Bietrix F; Lombardo E; van Roomen CP; Ottenhoff R; Vos M; Rensen PC; Verhoeven AJ; Aerts JM; Groen AK. 2010. Inhibition of glycosphingolipid synthesis induces a profound reduction of plasma cholesterol and inhibits atherosclerosis development in APOE*3 Leiden and low-density lipoprotein receptor-/- mice. Arterioscler Thromb Vasc Biol 30(5):931-7. [PubMed: 20167657]  [MGI Ref ID J:175820]

Billon-Gales A; Fontaine C; Douin-Echinard V; Delpy L; Berges H; Calippe B; Lenfant F; Laurell H; Guery JC; Gourdy P; Arnal JF. 2009. Endothelial estrogen receptor-alpha plays a crucial role in the atheroprotective action of 17beta-estradiol in low-density lipoprotein receptor-deficient mice. Circulation 120(25):2567-76. [PubMed: 19996016]  [MGI Ref ID J:168125]

Billon-Gales A; Fontaine C; Filipe C; Douin-Echinard V; Fouque MJ; Flouriot G; Gourdy P; Lenfant F; Laurell H; Krust A; Chambon P; Arnal JF. 2009. The transactivating function 1 of estrogen receptor alpha is dispensable for the vasculoprotective actions of 17beta-estradiol. Proc Natl Acad Sci U S A 106(6):2053-8. [PubMed: 19188600]  [MGI Ref ID J:144952]

Billon-Gales A; Krust A; Fontaine C; Abot A; Flouriot G; Toutain C; Berges H; Gadeau AP; Lenfant F; Gourdy P; Chambon P; Arnal JF. 2011. Activation function 2 (AF2) of estrogen receptor-alpha is required for the atheroprotective action of estradiol but not to accelerate endothelial healing. Proc Natl Acad Sci U S A 108(32):13311-6. [PubMed: 21788522]  [MGI Ref ID J:175619]

Binder CJ; Hartvigsen K; Chang MK; Miller M; Broide D; Palinski W; Curtiss LK; Corr M; Witztum JL. 2004. IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis. J Clin Invest 114(3):427-37. [PubMed: 15286809]  [MGI Ref ID J:118092]

Binder CJ; Horkko S; Dewan A; Chang MK; Kieu EP; Goodyear CS; Shaw PX; Palinski W; Witztum JL; Silverman GJ. 2003. Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL. Nat Med 9(6):736-43. [PubMed: 12740573]  [MGI Ref ID J:83726]

Bischoff ED; Daige CL; Petrowski M; Dedman H; Pattison J; Juliano J; Li AC; Schulman IG. 2010. Non-redundant roles for LXRalpha and LXRbeta in atherosclerosis susceptibility in low density lipoprotein receptor knockout mice. J Lipid Res 51(5):900-6. [PubMed: 20388921]  [MGI Ref ID J:160160]

Bjorkegren JL; Hagg S; Talukdar HA; Foroughi Asl H; Jain RK; Cedergren C; Shang MM; Rossignoli A; Takolander R; Melander O; Hamsten A; Michoel T; Skogsberg J. 2014. Plasma cholesterol-induced lesion networks activated before regression of early, mature, and advanced atherosclerosis. PLoS Genet 10(2):e1004201. [PubMed: 24586211]  [MGI Ref ID J:211003]

Blasiole DA; Oler AT; Attie AD. 2008. Regulation of ApoB secretion by the low density lipoprotein receptor requires exit from the endoplasmic reticulum and interaction with ApoE or ApoB. J Biol Chem 283(17):11374-81. [PubMed: 18272520]  [MGI Ref ID J:136523]

Boisvert WA; Rose DM; Johnson KA; Fuentes ME; Lira SA; Curtiss LK; Terkeltaub RA. 2006. Up-regulated expression of the CXCR2 Ligand KC/GRO-alpha in atherosclerotic lesions plays a central role in macrophage accumulation and lesion progression. Am J Pathol 168(4):1385-95. [PubMed: 16565511]  [MGI Ref ID J:107325]

Boisvert WA; Santiago R; Curtiss LK; Terkeltaub RA. 1998. A leukocyte homologue of the IL-8 receptor CXCR-2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice. J Clin Invest 101(2):353-63. [PubMed: 9435307]  [MGI Ref ID J:45392]

Bojic LA; Telford DE; Fullerton MD; Ford RJ; Sutherland BG; Edwards JY; Sawyez CG; Gros R; Kemp BE; Steinberg GR; Huff MW. 2014. PPARdelta activation attenuates hepatic steatosis in Ldlr-/- mice by enhanced fat oxidation, reduced lipogenesis, and improved insulin sensitivity. J Lipid Res 55(7):1254-1266. [PubMed: 24864274]  [MGI Ref ID J:214996]

Bol V; Desjardins F; Reusens B; Balligand JL; Remacle C. 2010. Does early mismatched nutrition predispose to hypertension and atherosclerosis, in male mice? PLoS One 5(9):. [PubMed: 20844591]  [MGI Ref ID J:165129]

Bolduc V; Baraghis E; Duquette N; Thorin-Trescases N; Lambert J; Lesage F; Thorin E. 2012. Catechin prevents severe dyslipidemia-associated changes in wall biomechanics of cerebral arteries in LDLr-/-:hApoB+/+ mice and improves cerebral blood flow. Am J Physiol Heart Circ Physiol 302(6):H1330-9. [PubMed: 22268108]  [MGI Ref ID J:186586]

Bolduc V; Drouin A; Gillis MA; Duquette N; Thorin-Trescases N; Frayne-Robillard I; Des Rosiers C; Tardif JC; Thorin E. 2011. Heart rate-associated mechanical stress impairs carotid but not cerebral artery compliance in dyslipidemic atherosclerotic mice. Am J Physiol Heart Circ Physiol 301(5):H2081-92. [PubMed: 21926346]  [MGI Ref ID J:178785]

Bolick DT; Skaflen MD; Johnson LE; Kwon SC; Howatt D; Daugherty A; Ravichandran KS; Hedrick CC. 2009. G2A deficiency in mice promotes macrophage activation and atherosclerosis. Circ Res 104(3):318-27. [PubMed: 19106413]  [MGI Ref ID J:163438]

Bonfleur ML; Vanzela EC; Ribeiro RA; de Gabriel Dorighello G; de Franca Carvalho CP; Collares-Buzato CB; Carneiro EM; Boschero AC; de Oliveira HC. 2010. Primary hypercholesterolaemia impairs glucose homeostasis and insulin secretion in low-density lipoprotein receptor knockout mice independently of high-fat diet and obesity. Biochim Biophys Acta 1801(2):183-90. [PubMed: 19913637]  [MGI Ref ID J:164825]

Bostrom MA; Boyanovsky BB; Jordan CT; Wadsworth MP; Taatjes DJ; de Beer FC; Webb NR. 2007. Group v secretory phospholipase A2 promotes atherosclerosis: evidence from genetically altered mice. Arterioscler Thromb Vasc Biol 27(3):600-6. [PubMed: 17204667]  [MGI Ref ID J:149057]

Bot M; Bot I; Lopez-Vales R; van de Lest CH; Saulnier-Blache JS; Helms JB; David S; van Berkel TJ; Biessen EA. 2010. Atherosclerotic lesion progression changes lysophosphatidic acid homeostasis to favor its accumulation. Am J Pathol 176(6):3073-84. [PubMed: 20431029]  [MGI Ref ID J:161328]

Bot M; Van Veldhoven PP; de Jager SC; Johnson J; Nijstad N; Van Santbrink PJ; Westra MM; Van Der Hoeven G; Gijbels MJ; Muller-Tidow C; Varga G; Tietge UJ; Kuiper J; Van Berkel TJ; Nofer JR; Bot I; Biessen EA. 2013. Hematopoietic sphingosine 1-phosphate lyase deficiency decreases atherosclerotic lesion development in LDL-receptor deficient mice. PLoS One 8(5):e63360. [PubMed: 23700419]  [MGI Ref ID J:200844]

Bot M; de Jager SC; MacAleese L; Lagraauw HM; van Berkel TJ; Quax PH; Kuiper J; Heeren RM; Biessen EA; Bot I. 2013. Lysophosphatidic acid triggers mast cell-driven atherosclerotic plaque destabilization by increasing vascular inflammation. J Lipid Res 54(5):1265-74. [PubMed: 23396975]  [MGI Ref ID J:196303]

Boucher P; Gotthardt M; Li WP; Anderson RG; Herz J. 2003. LRP: role in vascular wall integrity and protection from atherosclerosis. Science 300(5617):329-32. [PubMed: 12690199]  [MGI Ref ID J:82871]

Boucher P; Li WP; Matz RL; Takayama Y; Auwerx J; Anderson RG; Herz J. 2007. LRP1 functions as an atheroprotective integrator of TGFbeta and PDFG signals in the vascular wall: implications for Marfan syndrome. PLoS ONE 2(5):e448. [PubMed: 17505534]  [MGI Ref ID J:129347]

Bovenschen N; Mertens K; Hu L; Havekes LM; van Vlijmen BJ. 2005. LDL receptor cooperates with LDL receptor-related protein in regulating plasma levels of coagulation factor VIII in vivo. Blood 106(3):906-12. [PubMed: 15840700]  [MGI Ref ID J:117317]

Boyanovsky B; Zack M; Forrest K; Webb NR. 2009. The capacity of group V sPLA2 to increase atherogenicity of ApoE-/- and LDLR-/- mouse LDL in vitro predicts its atherogenic role in vivo. Arterioscler Thromb Vasc Biol 29(4):532-8. [PubMed: 19164803]  [MGI Ref ID J:159779]

Boyanovsky BB; van der Westhuyzen DR; Webb NR. 2005. Group V secretory phospholipase A2-modified low density lipoprotein promotes foam cell formation by a SR-A- and CD36-independent process that involves cellular proteoglycans. J Biol Chem 280(38):32746-52. [PubMed: 16040605]  [MGI Ref ID J:102157]

Bretillon L; Acar N; Seeliger MW; Santos M; Maire MA; Juaneda P; Martine L; Gregoire S; Joffre C; Bron AM; Creuzot-Garcher C. 2008. ApoB100,LDLR-/- mice exhibit reduced electroretinographic response and cholesteryl esters deposits in the retina. Invest Ophthalmol Vis Sci 49(4):1307-14. [PubMed: 18385042]  [MGI Ref ID J:136142]

Broedl UC; Maugeais C; Millar JS; Jin W; Moore RE; Fuki IV; Marchadier D; Glick JM; Rader DJ. 2004. Endothelial lipase promotes the catabolism of ApoB-containing lipoproteins. Circ Res 94(12):1554-61. [PubMed: 15117821]  [MGI Ref ID J:100064]

Brown JM; Bell TA 3rd; Alger HM; Sawyer JK; Smith TL; Kelley K; Shah R; Wilson MD; Davis MA; Lee RG; Graham MJ; Crooke RM; Rudel LL. 2008. Targeted depletion of hepatic ACAT2-driven cholesterol esterification reveals a non-biliary route for fecal neutral sterol loss. J Biol Chem 283(16):10522-34. [PubMed: 18281279]  [MGI Ref ID J:136556]

Brown JM; Chung S; Sawyer JK; Degirolamo C; Alger HM; Nguyen T; Zhu X; Duong MN; Wibley AL; Shah R; Davis MA; Kelley K; Wilson MD; Kent C; Parks JS; Rudel LL. 2008. Inhibition of stearoyl-coenzyme A desaturase 1 dissociates insulin resistance and obesity from atherosclerosis. Circulation 118(14):1467-75. [PubMed: 18794388]  [MGI Ref ID J:158044]

Brown JM; Chung S; Sawyer JK; Degirolamo C; Alger HM; Nguyen TM; Zhu X; Duong MN; Brown AL; Lord C; Shah R; Davis MA; Kelley K; Wilson MD; Madenspacher J; Fessler MB; Parks JS; Rudel LL. 2010. Combined therapy of dietary fish oil and stearoyl-CoA desaturase 1 inhibition prevents the metabolic syndrome and atherosclerosis. Arterioscler Thromb Vasc Biol 30(1):24-30. [PubMed: 19834103]  [MGI Ref ID J:171803]

Brunham LR; Singaraja RR; Duong M; Timmins JM; Fievet C; Bissada N; Kang MH; Samra A; Fruchart JC; McManus B; Staels B; Parks JS; Hayden MR. 2009. Tissue-specific roles of ABCA1 influence susceptibility to atherosclerosis. Arterioscler Thromb Vasc Biol 29(4):548-54. [PubMed: 19201688]  [MGI Ref ID J:159775]

Bu DX; Tarrio M; Maganto-Garcia E; Stavrakis G; Tajima G; Lederer J; Jarolim P; Freeman GJ; Sharpe AH; Lichtman AH. 2011. Impairment of the programmed cell death-1 pathway increases atherosclerotic lesion development and inflammation. Arterioscler Thromb Vasc Biol 31(5):1100-7. [PubMed: 21393583]  [MGI Ref ID J:191478]

Buga GM; Frank JS; Mottino GA; Hakhamian A; Narasimha A; Watson AD; Yekta B; Navab M; Reddy ST; Anantharamaiah GM; Fogelman AM. 2008. D-4F reduces EO6 immunoreactivity, SREBP-1c mRNA levels, and renal inflammation in LDL receptor-null mice fed a Western diet. J Lipid Res 49(1):192-205. [PubMed: 17925450]  [MGI Ref ID J:130095]

Buga GM; Frank JS; Mottino GA; Hendizadeh M; Hakhamian A; Tillisch JH; Reddy ST; Navab M; Anantharamaiah GM; Ignarro LJ; Fogelman AM. 2006. D-4F decreases brain arteriole inflammation and improves cognitive performance in LDL receptor-null mice on a Western diet. J Lipid Res 47(10):2148-60. [PubMed: 16835442]  [MGI Ref ID J:116493]

Buono C; Binder CJ; Stavrakis G; Witztum JL; Glimcher LH; Lichtman AH. 2005. T-bet deficiency reduces atherosclerosis and alters plaque antigen-specific immune responses. Proc Natl Acad Sci U S A 102(5):1596-601. [PubMed: 15665085]  [MGI Ref ID J:96110]

Buono C; Come CE; Stavrakis G; Maguire GF; Connelly PW; Lichtman AH. 2003. Influence of interferon-gamma on the extent and phenotype of diet-induced atherosclerosis in the LDLR-deficient mouse. Arterioscler Thromb Vasc Biol 23(3):454-60. [PubMed: 12615659]  [MGI Ref ID J:103072]

Buono C; Come CE; Witztum JL; Maguire GF; Connelly PW; Carroll M; Lichtman AH. 2002. Influence of C3 deficiency on atherosclerosis. Circulation 105(25):3025-31. [PubMed: 12081998]  [MGI Ref ID J:103349]

Burkhardt R; Sundermann S; Ludwig D; Ceglarek U; Holdt LM; Thiery J; Teupser D. 2011. Cosegregation of aortic root atherosclerosis and intermediate lipid phenotypes on chromosomes 2 and 8 in an intercross of C57BL/6 and BALBc/ByJ low-density lipoprotein receptor-/- mice. Arterioscler Thromb Vasc Biol 31(4):775-84. [PubMed: 21252064]  [MGI Ref ID J:184168]

Burkhardt R; Toh SA; Lagor WR; Birkeland A; Levin M; Li X; Robblee M; Fedorov VD; Yamamoto M; Satoh T; Akira S; Kathiresan S; Breslow JL; Rader DJ. 2010. Trib1 is a lipid- and myocardial infarction-associated gene that regulates hepatic lipogenesis and VLDL production in mice. J Clin Invest 120(12):4410-4. [PubMed: 21084752]  [MGI Ref ID J:171867]

Burleigh ME; Babaev VR; Oates JA; Harris RC; Gautam S; Riendeau D; Marnett LJ; Morrow JD; Fazio S; Linton MF. 2002. Cyclooxygenase-2 promotes early atherosclerotic lesion formation in LDL receptor-deficient mice. Circulation 105(15):1816-23. [PubMed: 11956125]  [MGI Ref ID J:103220]

Busch M; Westhofen TC; Koch M; Lutz MB; Zernecke A. 2014. Dendritic cell subset distributions in the aorta in healthy and atherosclerotic mice. PLoS One 9(2):e88452. [PubMed: 24551105]  [MGI Ref ID J:213070]

Cain WJ; Millar JS; Himebauch AS; Tietge UJ; Maugeais C; Usher D; Rader DJ. 2005. Lipoprotein [a] is cleared from the plasma primarily by the liver in a process mediated by apolipoprotein [a]. J Lipid Res 46(12):2681-91. [PubMed: 16150825]  [MGI Ref ID J:106146]

Calara F; Silvestre M; Casanada F; Yuan N; Napoli C; Palinski W. 2001. Spontaneous plaque rupture and secondary thrombosis in apolipoprotein E-deficient and LDL receptor-deficient mice. J Pathol 195(2):257-63. [PubMed: 11592107]  [MGI Ref ID J:71794]

Caligiuri G; Levy B; Pernow J; Thoren P; Hansson GK. 1999. Myocardial infarction mediated by endothelin receptor signaling in hypercholesterolemic mice. Proc Natl Acad Sci U S A 96(12):6920-4. [PubMed: 10359814]  [MGI Ref ID J:55973]

Campbell IC; Weiss D; Suever JD; Virmani R; Veneziani A; Vito RP; Oshinski JN; Taylor WR. 2013. Biomechanical modeling and morphology analysis indicates plaque rupture due to mechanical failure unlikely in atherosclerosis-prone mice. Am J Physiol Heart Circ Physiol 304(3):H473-86. [PubMed: 23203971]  [MGI Ref ID J:194633]

Cao D; Fukuchi K; Wan H; Kim H; Li L. 2006. Lack of LDL receptor aggravates learning deficits and amyloid deposits in Alzheimer transgenic mice. Neurobiol Aging 27(11):1632-43. [PubMed: 16236385]  [MGI Ref ID J:114480]

Cao Q; Wang X; Jia L; Mondal AK; Diallo A; Hawkins GA; Das SK; Parks JS; Yu L; Shi H; Shi H; Xue B. 2014. Inhibiting DNA Methylation by 5-Aza-2'-deoxycytidine ameliorates atherosclerosis through suppressing macrophage inflammation. Endocrinology 155(12):4925-38. [PubMed: 25251587]  [MGI Ref ID J:219682]

Carpenter B; Lin Y; Stoll S; Raffai RL; McCuskey R; Wang R. 2005. VEGF is crucial for the hepatic vascular development required for lipoprotein uptake. Development 132(14):3293-303. [PubMed: 15944181]  [MGI Ref ID J:100427]

Casagrande V; Menghini R; Menini S; Marino A; Marchetti V; Cavalera M; Fabrizi M; Hribal ML; Pugliese G; Gentileschi P; Schillaci O; Porzio O; Lauro D; Sbraccia P; Lauro R; Federici M. 2012. Overexpression of tissue inhibitor of metalloproteinase 3 in macrophages reduces atherosclerosis in low-density lipoprotein receptor knockout mice. Arterioscler Thromb Vasc Biol 32(1):74-81. [PubMed: 22015660]  [MGI Ref ID J:195978]

Casquero AC; Berti JA; Salerno AG; Bighetti EJ; Cazita PM; Ketelhuth DF; Gidlund M; Oliveira HC. 2006. Atherosclerosis is enhanced by testosterone deficiency and attenuated by CETP expression in transgenic mice. J Lipid Res 47(7):1526-34. [PubMed: 16603720]  [MGI Ref ID J:112057]

Cassis LA; Gupte M; Thayer S; Zhang X; Charnigo R; Howatt DA; Rateri DL; Daugherty A. 2009. ANG II infusion promotes abdominal aortic aneurysms independent of increased blood pressure in hypercholesterolemic mice. Am J Physiol Heart Circ Physiol 296(5):H1660-5. [PubMed: 19252100]  [MGI Ref ID J:150893]

Cassis LA; Rateri DL; Lu H; Daugherty A. 2007. Bone marrow transplantation reveals that recipient AT1a receptors are required to initiate angiotensin II-induced atherosclerosis and aneurysms. Arterioscler Thromb Vasc Biol 27(2):380-6. [PubMed: 17158350]  [MGI Ref ID J:130546]

Castellani LW; Chang JJ; Wang X; Lusis AJ; Reynolds WF. 2006. Transgenic mice express human MPO -463G/A alleles at atherosclerotic lesions, developing hyperlipidemia and obesity in -463G males. J Lipid Res 47(7):1366-77. [PubMed: 16639078]  [MGI Ref ID J:112085]

Catanozi S; Rocha JC; Passarelli M; Guzzo ML; Alves C; Furukawa LN; Nunes VS; Nakandakare ER; Heimann JC; Quintao EC. 2003. Dietary sodium chloride restriction enhances aortic wall lipid storage and raises plasma lipid concentration in LDL receptor knockout mice. J Lipid Res 44(4):727-32. [PubMed: 12562870]  [MGI Ref ID J:120709]

Cazita PM; Berti JA; Aoki C; Gidlund M; Harada LM; Nunes VS; Quintao EC; Oliveira HC. 2003. Cholesteryl ester transfer protein expression attenuates atherosclerosis in ovariectomized mice. J Lipid Res 44(1):33-40. [PubMed: 12518020]  [MGI Ref ID J:120685]

Chadjichristos CE; Matter CM; Roth I; Sutter E; Pelli G; Luscher TF; Chanson M; Kwak BR. 2006. Reduced connexin43 expression limits neointima formation after balloon distension injury in hypercholesterolemic mice. Circulation 113(24):2835-43. [PubMed: 16769907]  [MGI Ref ID J:122443]

Chakraborty M; Lou C; Huan C; Kuo MS; Park TS; Cao G; Jiang XC. 2013. Myeloid cell-specific serine palmitoyltransferase subunit 2 haploinsufficiency reduces murine atherosclerosis. J Clin Invest 123(4):1784-97. [PubMed: 23549085]  [MGI Ref ID J:197606]

Chan JC; Piper DE; Cao Q; Liu D; King C; Wang W; Tang J; Liu Q; Higbee J; Xia Z; Di Y; Shetterly S; Arimura Z; Salomonis H; Romanow WG; Thibault ST; Zhang R; Cao P; Yang XP; Yu T; Lu M; Retter MW; Kwon G; Henne K; Pan O; Tsai MM; Fuchslocher B; Yang E; Zhou L; Lee KJ; Daris M; Sheng J; Wang Y; Shen WD; Yeh WC; Emery M; Walker NP; Shan B; Schwarz M; Jackson SM. 2009. A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates. Proc Natl Acad Sci U S A 106(24):9820-5. [PubMed: 19443683]  [MGI Ref ID J:150005]

Chehaibi K; Cedo L; Metso J; Palomer X; Santos D; Quesada H; Naceur Slimane M; Wahli W; Julve J; Vazquez-Carrera M; Jauhiainen M; Blanco-Vaca F; Escola-Gil JC. 2015. PPAR-beta/delta activation promotes phospholipid transfer protein expression. Biochem Pharmacol 94(2):101-8. [PubMed: 25662586]  [MGI Ref ID J:219883]

Chellan B; Koroleva EP; Sontag TJ; Tumanov AV; Fu YX; Getz GS; Reardon CA. 2013. LIGHT/TNFSR14 can regulate hepatic lipase expression by hepatocytes independent of T cells and Kupffer cells. PLoS One 8(1):e54719. [PubMed: 23355893]  [MGI Ref ID J:195803]

Chen CT; Ma DW; Kim JH; Mount HT; Bazinet RP. 2008. The low density lipoprotein receptor is not necessary for maintaining mouse brain polyunsaturated fatty acid concentrations. J Lipid Res 49(1):147-52. [PubMed: 17932396]  [MGI Ref ID J:130078]

Chen X; Rateri DL; Howatt DA; Balakrishnan A; Moorleghen JJ; Morris AJ; Charnigo R; Cassis LA; Daugherty A. 2013. Amlodipine reduces AngII-induced aortic aneurysms and atherosclerosis in hypercholesterolemic mice. PLoS One 8(11):e81743. [PubMed: 24244746]  [MGI Ref ID J:209689]

Chen Z; Fitzgerald RL; Li G; Davidson NO; Schonfeld G. 2004. Hepatic secretion of apoB-100 is impaired in hypobetalipoproteinemic mice with an apoB-38.9-specifying allele. J Lipid Res 45(1):155-63. [PubMed: 13130124]  [MGI Ref ID J:87974]

Cheng SL; Shao JS; Halstead LR; Distelhorst K; Sierra O; Towler DA. 2010. Activation of vascular smooth muscle parathyroid hormone receptor inhibits Wnt/beta-catenin signaling and aortic fibrosis in diabetic arteriosclerosis. Circ Res 107(2):271-82. [PubMed: 20489161]  [MGI Ref ID J:175050]

Choi JH; Cheong C; Dandamudi DB; Park CG; Rodriguez A; Mehandru S; Velinzon K; Jung IH; Yoo JY; Oh GT; Steinman RM. 2011. Flt3 Signaling-Dependent Dendritic Cells Protect against Atherosclerosis. Immunity 35(5):819-31. [PubMed: 22078798]  [MGI Ref ID J:178831]

Choi JH; Nam KH; Kim J; Baek MW; Park JE; Park HY; Kwon HJ; Kwon OS; Kim DY; Oh GT. 2005. Trichostatin A exacerbates atherosclerosis in low density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol 25(11):2404-9. [PubMed: 16141407]  [MGI Ref ID J:116800]

Christoffersen C; Benn M; Christensen PM; Gordts PL; Roebroek AJ; Frikke-Schmidt R; Tybjaerg-Hansen A; Dahlback B; Nielsen LB. 2012. The plasma concentration of HDL-associated apoM is influenced by LDL receptor-mediated clearance of apoB-containing particles. J Lipid Res 53(10):2198-204. [PubMed: 22826357]  [MGI Ref ID J:188041]

Christoffersen C; Jauhiainen M; Moser M; Porse B; Ehnholm C; Boesl M; Dahlback B; Nielsen LB. 2008. Effect of apolipoprotein M on high density lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knock-out mice. J Biol Chem 283(4):1839-47. [PubMed: 18006500]  [MGI Ref ID J:130647]

Christoffersen C; Pedersen TX; Gordts PL; Roebroek AJ; Dahlback B; Nielsen LB. 2010. Opposing effects of apolipoprotein m on catabolism of apolipoprotein B-containing lipoproteins and atherosclerosis. Circ Res 106(10):1624-34. [PubMed: 20360257]  [MGI Ref ID J:172136]

Cochain C; Chaudhari SM; Koch M; Wiendl H; Eckstein HH; Zernecke A. 2014. Programmed cell death-1 deficiency exacerbates T cell activation and atherogenesis despite expansion of regulatory T cells in atherosclerosis-prone mice. PLoS One 9(4):e93280. [PubMed: 24691202]  [MGI Ref ID J:215043]

Coenen KR; Gruen ML; Chait A; Hasty AH. 2007. Diet-induced increases in adiposity, but not plasma lipids, promote macrophage infiltration into white adipose tissue. Diabetes 56(3):564-73. [PubMed: 17327423]  [MGI Ref ID J:122029]

Coenen KR; Gruen ML; Lee-Young RS; Puglisi MJ; Wasserman DH; Hasty AH. 2009. Impact of macrophage toll-like receptor 4 deficiency on macrophage infiltration into adipose tissue and the artery wall in mice. Diabetologia 52(2):318-28. [PubMed: 19052722]  [MGI Ref ID J:144370]

Coenen KR; Hasty AH. 2007. Obesity potentiates development of fatty liver and insulin resistance, but not atherosclerosis, in high-fat diet-fed agouti LDLR-deficient mice. Am J Physiol Endocrinol Metab 293(2):E492-9. [PubMed: 17566116]  [MGI Ref ID J:123342]

Collins AR; Gupte AA; Ji R; Ramirez MR; Minze LJ; Liu JZ; Arredondo M; Ren Y; Deng T; Wang J; Lyon CJ; Hsueh WA. 2012. Myeloid deletion of nuclear factor erythroid 2-related factor 2 increases atherosclerosis and liver injury. Arterioscler Thromb Vasc Biol 32(12):2839-46. [PubMed: 23023374]  [MGI Ref ID J:208317]

Constantinou C; Mpatsoulis D; Natsos A; Petropoulou PI; Zvintzou E; Traish AM; Voshol PJ; Karagiannides I; Kypreos KE. 2014. The low density lipoprotein receptor modulates the effects of hypogonadism on diet-induced obesity and related metabolic perturbations. J Lipid Res 55(7):1434-1447. [PubMed: 24837748]  [MGI Ref ID J:215003]

Curtiss LK; Black AS; Bonnet DJ; Tobias PS. 2012. Atherosclerosis induced by endogenous and exogenous toll-like receptor (TLR)1 or TLR6 agonists. J Lipid Res 53(10):2126-32. [PubMed: 22822027]  [MGI Ref ID J:188042]

Cybulsky MI; Iiyama K; Li H; Zhu S; Chen M; Iiyama M; Davis V; Gutierrez-Ramos JC; Connelly PW; Milstone DS. 2001. A major role for VCAM-1, but not ICAM-1, in early atherosclerosis. J Clin Invest 107(10):1255-62. [PubMed: 11375415]  [MGI Ref ID J:69597]

Cyrus T; Tang LX; Rokach J; FitzGerald GA; Pratico D. 2001. Lipid peroxidation and platelet activation in murine atherosclerosis. Circulation 104(16):1940-5. [PubMed: 11602498]  [MGI Ref ID J:103216]

Daissormont IT; Christ A; Temmerman L; Sampedro Millares S; Seijkens T; Manca M; Rousch M; Poggi M; Boon L; van der Loos C; Daemen M; Lutgens E; Halvorsen B; Aukrust P; Janssen E; Biessen EA. 2011. Plasmacytoid dendritic cells protect against atherosclerosis by tuning T-cell proliferation and activity. Circ Res 109(12):1387-95. [PubMed: 22021930]  [MGI Ref ID J:192720]

Dandapat A; Hu CP; Chen J; Liu Y; Khan JA; Remeo F; Carey RM; Hermonat PL; Mehta JL. 2008. Over-expression of angiotensin II type 2 receptor (agtr2) decreases collagen accumulation in atherosclerotic plaque. Biochem Biophys Res Commun 366(4):871-7. [PubMed: 18037370]  [MGI Ref ID J:130186]

Daugherty A; Rateri DL; Howatt DA; Charnigo R; Cassis LA. 2013. PD123319 augments angiotensin II-induced abdominal aortic aneurysms through an AT2 receptor-independent mechanism. PLoS One 8(4):e61849. [PubMed: 23593499]  [MGI Ref ID J:200118]

Davies MR; Lund RJ; Mathew S; Hruska KA. 2005. Low turnover osteodystrophy and vascular calcification are amenable to skeletal anabolism in an animal model of chronic kidney disease and the metabolic syndrome. J Am Soc Nephrol 16(4):917-28. [PubMed: 15743994]  [MGI Ref ID J:110048]

Day SM; Reeve JL; Pedersen B; Farris DM; Myers DD; Im M; Wakefield TW; Mackman N; Fay WP. 2005. Macrovascular thrombosis is driven by tissue factor derived primarily from the blood vessel wall. Blood 105(1):192-8. [PubMed: 15339841]  [MGI Ref ID J:96377]

Deane R; Sagare A; Hamm K; Parisi M; Lane S; Finn MB; Holtzman DM; Zlokovic BV. 2008. apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain. J Clin Invest 118(12):4002-13. [PubMed: 19033669]  [MGI Ref ID J:144730]

Deevska GM; Rozenova KA; Giltiay NV; Chambers MA; White J; Boyanovsky BB; Wei J; Daugherty A; Smart EJ; Reid MB; Merrill AH Jr; Nikolova-Karakashian M. 2009. Acid Sphingomyelinase Deficiency Prevents Diet-induced Hepatic Triacylglycerol Accumulation and Hyperglycemia in Mice. J Biol Chem 284(13):8359-68. [PubMed: 19074137]  [MGI Ref ID J:148558]

Degrace P; Moindrot B; Mohamed I; Gresti J; Du ZY; Chardigny JM; Sebedio JL; Clouet P. 2006. Upregulation of liver VLDL receptor and FAT/CD36 expression in LDLR-/- apoB100/100 mice fed trans-10,cis-12 conjugated linoleic acid. J Lipid Res 47(12):2647-55. [PubMed: 16957181]  [MGI Ref ID J:117203]

Denis M; Marcinkiewicz J; Zaid A; Gauthier D; Poirier S; Lazure C; Seidah NG; Prat A. 2012. Gene inactivation of proprotein convertase subtilisin/kexin type 9 reduces atherosclerosis in mice. Circulation 125(7):894-901. [PubMed: 22261195]  [MGI Ref ID J:196628]

Depner CM; Torres-Gonzalez M; Tripathy S; Milne G; Jump DB. 2012. Menhaden oil decreases high-fat diet-induced markers of hepatic damage, steatosis, inflammation, and fibrosis in obese ldlr-/- mice. J Nutr 142(8):1495-503. [PubMed: 22739374]  [MGI Ref ID J:186393]

Derwall M; Malhotra R; Lai CS; Beppu Y; Aikawa E; Seehra JS; Zapol WM; Bloch KD; Yu PB. 2012. Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis. Arterioscler Thromb Vasc Biol 32(3):613-22. [PubMed: 22223731]  [MGI Ref ID J:195959]

Devlin CM; Kuriakose G; Hirsch E; Tabas I. 2002. Genetic alterations of IL-1 receptor antagonist in mice affect plasma cholesterol level and foam cell lesion size. Proc Natl Acad Sci U S A 99(9):6280-5. [PubMed: 11983917]  [MGI Ref ID J:76336]

Devlin CM; Leventhal AR; Kuriakose G; Schuchman EH; Williams KJ; Tabas I. 2008. Acid sphingomyelinase promotes lipoprotein retention within early atheromata and accelerates lesion progression. Arterioscler Thromb Vasc Biol 28(10):1723-30. [PubMed: 18669882]  [MGI Ref ID J:148825]

Dichek HL; Agrawal N; El Andaloussi N; Qian K. 2006. Attenuated corticosterone response to chronic ACTH stimulation in hepatic lipase-deficient mice: evidence for a role for hepatic lipase in adrenal physiology. Am J Physiol Endocrinol Metab 290(5):E908-15. [PubMed: 16368783]  [MGI Ref ID J:108412]

Dichek HL; Johnson SM; Akeefe H; Lo GT; Sage E; Yap CE; Mahley RW. 2001. Hepatic lipase overexpression lowers remnant and LDL levels by a noncatalytic mechanism in LDL receptor-deficient mice. J Lipid Res 42(2):201-10. [PubMed: 11181749]  [MGI Ref ID J:68351]

Dichek HL; Qian K; Agrawal N. 2004. Divergent effects of the catalytic and bridging functions of hepatic lipase on atherosclerosis. Arterioscler Thromb Vasc Biol 24(9):1696-702. [PubMed: 15205216]  [MGI Ref ID J:134693]

Dichek HL; Qian K; Agrawal N. 2004. The bridging function of hepatic lipase clears plasma cholesterol in LDL receptor-deficient 'apoB-48-only' and 'apoB-100-only' mice. J Lipid Res 45(3):551-60. [PubMed: 14679168]  [MGI Ref ID J:88634]

Ding Z; Mizeracki AM; Hu C; Mehta JL. 2013. LOX-1 deletion and macrophage trafficking in atherosclerosis. Biochem Biophys Res Commun 440(2):210-4. [PubMed: 24036126]  [MGI Ref ID J:211431]

Dong Y; Zhang M; Liang B; Xie Z; Zhao Z; Asfa S; Choi HC; Zou MH. 2010. Reduction of AMP-activated protein kinase alpha2 increases endoplasmic reticulum stress and atherosclerosis in vivo. Circulation 121(6):792-803. [PubMed: 20124121]  [MGI Ref ID J:170442]

Doring Y; Manthey HD; Drechsler M; Lievens D; Megens RT; Soehnlein O; Busch M; Manca M; Koenen RR; Pelisek J; Daemen MJ; Lutgens E; Zenke M; Binder CJ; Weber C; Zernecke A. 2012. Auto-antigenic protein-DNA complexes stimulate plasmacytoid dendritic cells to promote atherosclerosis. Circulation 125(13):1673-83. [PubMed: 22388324]  [MGI Ref ID J:198616]

Drechsler M; Megens RT; van Zandvoort M; Weber C; Soehnlein O. 2010. Hyperlipidemia-triggered neutrophilia promotes early atherosclerosis. Circulation 122(18):1837-45. [PubMed: 20956207]  [MGI Ref ID J:179481]

Drouin A; Bolduc V; Thorin-Trescases N; Belanger E; Fernandes P; Baraghis E; Lesage F; Gillis MA; Villeneuve L; Hamel E; Ferland G; Thorin E. 2010. Catechin treatment improves cerebrovascular flow-mediated dilation and learning abilities in atherosclerotic mice. Am J Physiol Heart Circ Physiol :. [PubMed: 21186270]  [MGI Ref ID J:167205]

Duewell P; Kono H; Rayner KJ; Sirois CM; Vladimer G; Bauernfeind FG; Abela GS; Franchi L; Nunez G; Schnurr M; Espevik T; Lien E; Fitzgerald KA; Rock KL; Moore KJ; Wright SD; Hornung V; Latz E. 2010. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature 464(7293):1357-61. [PubMed: 20428172]  [MGI Ref ID J:159453]

Dullens SP; Mensink RP; Bragt MC; Kies AK; Plat J. 2008. Effects of emulsified policosanols with different chain lengths on cholesterol metabolism in heterozygous LDL receptor-deficient mice. J Lipid Res 49(4):790-6. [PubMed: 18162663]  [MGI Ref ID J:133589]

Dupasquier CM; Dibrov E; Kneesh AL; Cheung PK; Lee KG; Alexander HK; Yeganeh BK; Moghadasian MH; Pierce GN. 2007. Dietary flaxseed inhibits atherosclerosis in the LDL receptor-deficient mouse in part through antiproliferative and anti-inflammatory actions. Am J Physiol Heart Circ Physiol 293(4):H2394-402. [PubMed: 17616740]  [MGI Ref ID J:126120]

Eberle C; Merki E; Yamashita T; Johnson S; Armando AM; Quehenberger O; Napoli C; Palinski W. 2012. Maternal immunization affects in utero programming of insulin resistance and type 2 diabetes. PLoS One 7(9):e45361. [PubMed: 23028961]  [MGI Ref ID J:192004]

Egan KM; Lawson JA; Fries S; Koller B; Rader DJ; Smyth EM; Fitzgerald GA. 2004. COX-2-derived prostacyclin confers atheroprotection on female mice. Science 306(5703):1954-7. [PubMed: 15550624]  [MGI Ref ID J:105640]

Elder GA; Cho JY; English DF; Franciosi S; Schmeidler J; Sosa MA; Gasperi RD; Fisher EA; Mathews PM; Haroutunian V; Buxbaum JD. 2007. Elevated plasma cholesterol does not affect brain Abeta in mice lacking the low-density lipoprotein receptor. J Neurochem 102(4):1220-31. [PubMed: 17472705]  [MGI Ref ID J:124132]

Elder GA; Ragnauth A; Dorr N; Franciosi S; Schmeidler J; Haroutunian V; Buxbaum JD. 2008. Increased locomotor activity in mice lacking the low-density lipoprotein receptor. Behav Brain Res 191(2):256-265. [PubMed: 18466986]  [MGI Ref ID J:135078]

Erickson RP; Bhattacharyya A; Hunter RJ; Heidenreich RA; Cherrington NJ. 2005. Liver disease with altered bile acid transport in Niemann-Pick C mice on a high-fat, 1% cholesterol diet. Am J Physiol Gastrointest Liver Physiol 289(2):G300-7. [PubMed: 15790756]  [MGI Ref ID J:100351]

Erickson RP; Kiela M; Garver WS; Krishnan K; Heidenreich RA. 2001. Cholesterol signaling at the endoplasmic reticulum occurs in npc1(-/-) but not in npc1(-/-), LDLR(-/-) mice. Biochem Biophys Res Commun 284(2):326-30. [PubMed: 11394880]  [MGI Ref ID J:69915]

Eriksson EE; Xie X; Werr J; Thoren P; Lindbom L. 2001. Direct viewing of atherosclerosis in vivo: plaque invasion by leukocytes is initiated by the endothelial selectins. FASEB J 15(7):1149-57. [PubMed: 11344083]  [MGI Ref ID J:120455]

Eriksson EE; Xie X; Werr J; Thoren P; Lindbom L. 2001. Importance of primary capture and L-selectin-dependent secondary capture in leukocyte accumulation in inflammation and atherosclerosis in vivo. J Exp Med 194(2):205-18. [PubMed: 11457895]  [MGI Ref ID J:118726]

Espirito Santo SM; Pires NM; Boesten LS; Gerritsen G; Bovenschen N; van Dijk KW; Jukema JW; Princen HM; Bensadoun A; Li WP; Herz J; Havekes LM; van Vlijmen BJ. 2004. Hepatic low-density lipoprotein receptor-related protein deficiency in mice increases atherosclerosis independent of plasma cholesterol. Blood 103(10):3777-82. [PubMed: 14739216]  [MGI Ref ID J:90547]

Estrada-Smith D; Collins AR; Wang X; Crockett C; Castellani L; Lusis AJ; Davis RC. 2006. Impact of chromosome 2 obesity loci on cardiovascular complications of insulin resistance in LDL receptor-deficient C57BL/6 mice. Diabetes 55(8):2265-71. [PubMed: 16873689]  [MGI Ref ID J:116503]

Fan J; Stukas S; Wong C; Chan J; May S; Devalle N; Hirsch-Reinshagen V; Wilkinson A; Oda MN; Wellington CL. 2011. An ABCA1-independent pathway for recycling a poorly lipidated 8.1 nm apolipoprotein E particle from glia. J Lipid Res 52(9):1605-16. [PubMed: 21705806]  [MGI Ref ID J:175557]

Farris SD; Hu JH; Krishnan R; Emery I; Chu T; Du L; Kremen M; Dichek HL; Gold E; Ramsey SA; Dichek DA. 2011. Mechanisms of urokinase plasminogen activator (uPA)-mediated atherosclerosis: role of the uPA receptor and S100A8/A9 proteins. J Biol Chem 286(25):22665-77. [PubMed: 21536666]  [MGI Ref ID J:174810]

Fazio S; Babaev VR; Burleigh ME; Major AS; Hasty AH; Linton MF. 2002. Physiological expression of macrophage apoE in the artery wall reduces atherosclerosis in severely hyperlipidemic mice. J Lipid Res 43(10):1602-9. [PubMed: 12364544]  [MGI Ref ID J:79439]

Fazio S; Hasty AH; Carter KJ; Murray AB; Price JO; Linton MF. 1997. Leukocyte low density lipoprotein receptor (LDL-R) does not contribute to LDL clearance in vivo: bone marrow transplantation studies in the mouse. J Lipid Res 38(2):391-400. [PubMed: 9162757]  [MGI Ref ID J:38840]

Feig JE; Parathath S; Rong JX; Mick SL; Vengrenyuk Y; Grauer L; Young SG; Fisher EA. 2011. Reversal of hyperlipidemia with a genetic switch favorably affects the content and inflammatory state of macrophages in atherosclerotic plaques. Circulation 123(9):989-98. [PubMed: 21339485]  [MGI Ref ID J:183750]

Feig JE; Pineda-Torra I; Sanson M; Bradley MN; Vengrenyuk Y; Bogunovic D; Gautier EL; Rubinstein D; Hong C; Liu J; Wu C; van Rooijen N; Bhardwaj N; Garabedian M; Tontonoz P; Fisher EA. 2010. LXR promotes the maximal egress of monocyte-derived cells from mouse aortic plaques during atherosclerosis regression. J Clin Invest 120(12):4415-24. [PubMed: 21041949]  [MGI Ref ID J:171875]

Feng Y; Schouteden S; Geenens R; Van Duppen V; Herijgers P; Holvoet P; Van Veldhoven PP; Verfaillie CM. 2012. Hematopoietic stem/progenitor cell proliferation and differentiation is differentially regulated by high-density and low-density lipoproteins in mice. PLoS One 7(11):e47286. [PubMed: 23144813]  [MGI Ref ID J:194860]

Findeisen HM; Gizard F; Zhao Y; Cohn D; Heywood EB; Jones KL; Lovett DH; Howatt DA; Daugherty A; Bruemmer D. 2011. Telomerase deficiency in bone marrow-derived cells attenuates angiotensin II-induced abdominal aortic aneurysm formation. Arterioscler Thromb Vasc Biol 31(2):253-60. [PubMed: 21088250]  [MGI Ref ID J:184181]

Foks AC; Ran IA; Frodermann V; Bot I; van Santbrink PJ; Kuiper J; van Puijvelde GH. 2013. Agonistic anti-TIGIT treatment inhibits T cell responses in LDLr deficient mice without affecting atherosclerotic lesion development. PLoS One 8(12):e83134. [PubMed: 24376654]  [MGI Ref ID J:211124]

Foks AC; Ran IA; Wasserman L; Frodermann V; Ter Borg MN; de Jager SC; van Santbrink PJ; Yagita H; Akiba H; Bot I; Kuiper J; van Puijvelde GH. 2013. T-cell immunoglobulin and mucin domain 3 acts as a negative regulator of atherosclerosis. Arterioscler Thromb Vasc Biol 33(11):2558-65. [PubMed: 23990206]  [MGI Ref ID J:222219]

Foks AC; van Puijvelde GH; Bot I; ter Borg MN; Habets KL; Johnson JL; Yagita H; van Berkel TJ; Kuiper J. 2013. Interruption of the OX40-OX40 ligand pathway in LDL receptor-deficient mice causes regression of atherosclerosis. J Immunol 191(9):4573-80. [PubMed: 24068673]  [MGI Ref ID J:206243]

Fontana K; Campos GE; Staron RS; da Cruz-Hofling MA. 2013. Effects of anabolic steroids and high-intensity aerobic exercise on skeletal muscle of transgenic mice. PLoS One 8(11):e80909. [PubMed: 24260508]  [MGI Ref ID J:209673]

Forte TM; Subbanagounder G; Berliner JA; Blanche PJ; Clermont AO; Jia Z; Oda MN; Krauss RM; Bielicki JK. 2002. Altered activities of anti-atherogenic enzymes LCAT, paraoxonase, and platelet-activating factor acetylhydrolase in atherosclerosis-susceptible mice. J Lipid Res 43(3):477-85. [PubMed: 11893784]  [MGI Ref ID J:75568]

Fougerat A; Gayral S; Gourdy P; Schambourg A; Ruckle T; Schwarz MK; Rommel C; Hirsch E; Arnal JF; Salles JP; Perret B; Breton-Douillon M; Wymann MP; Laffargue M. 2008. Genetic and pharmacological targeting of phosphoinositide 3-kinase-gamma reduces atherosclerosis and favors plaque stability by modulating inflammatory processes. Circulation 117(10):1310-7. [PubMed: 18268153]  [MGI Ref ID J:148451]

Franco C; Ahmad PJ; Hou G; Wong E; Bendeck MP. 2010. Increased cell and matrix accumulation during atherogenesis in mice with vessel wall-specific deletion of discoidin domain receptor 1. Circ Res 106(11):1775-83. [PubMed: 20448217]  [MGI Ref ID J:172702]

Franco C; Britto K; Wong E; Hou G; Zhu SN; Chen M; Cybulsky MI; Bendeck MP. 2009. Discoidin domain receptor 1 on bone marrow-derived cells promotes macrophage accumulation during atherogenesis. Circ Res 105(11):1141-8. [PubMed: 19834008]  [MGI Ref ID J:170145]

Franco C; Hou G; Ahmad PJ; Fu EY; Koh L; Vogel WF; Bendeck MP. 2008. Discoidin domain receptor 1 (ddr1) deletion decreases atherosclerosis by accelerating matrix accumulation and reducing inflammation in low-density lipoprotein receptor-deficient mice. Circ Res 102(10):1202-11. [PubMed: 18451340]  [MGI Ref ID J:149015]

Francone OL; Royer L; Boucher G; Haghpassand M; Freeman A; Brees D; Aiello RJ. 2005. Increased cholesterol deposition, expression of scavenger receptors, and response to chemotactic factors in Abca1-deficient macrophages. Arterioscler Thromb Vasc Biol 25(6):1198-205. [PubMed: 15831807]  [MGI Ref ID J:114227]

Freeman L; Amar MJ; Shamburek R; Paigen B; Brewer HB Jr; Santamarina-Fojo S; Gonzalez-Navarro H. 2007. Lipolytic and ligand-binding functions of hepatic lipase protect against atherosclerosis in LDL receptor-deficient mice. J Lipid Res 48(1):104-13. [PubMed: 17071916]  [MGI Ref ID J:117481]

Freigang S; Ampenberger F; Weiss A; Kanneganti TD; Iwakura Y; Hersberger M; Kopf M. 2013. Fatty acid-induced mitochondrial uncoupling elicits inflammasome-independent IL-1alpha and sterile vascular inflammation in atherosclerosis. Nat Immunol 14(10):1045-53. [PubMed: 23995233]  [MGI Ref ID J:208219]

Freigang S; Landais E; Zadorozhny V; Kain L; Yoshida K; Liu Y; Deng S; Palinski W; Savage PB; Bendelac A; Teyton L. 2012. Scavenger receptors target glycolipids for natural killer T cell activation. J Clin Invest 122(11):3943-54. [PubMed: 23064364]  [MGI Ref ID J:193547]

Freigang S; Zadorozhny V; McKinney MK; Krebs P; Herro R; Pawlak J; Kain L; Schrantz N; Masuda K; Liu Y; Savage PB; Bendelac A; Cravatt BF; Teyton L. 2010. Fatty acid amide hydrolase shapes NKT cell responses by influencing the serum transport of lipid antigen in mice. J Clin Invest 120(6):1873-84. [PubMed: 20484813]  [MGI Ref ID J:161640]

Fryer JD; Demattos RB; McCormick LM; O'Dell MA; Spinner ML; Bales KR; Paul SM; Sullivan PM; Parsadanian M; Bu G; Holtzman DM. 2005. The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice. J Biol Chem 280(27):25754-9. [PubMed: 15888448]  [MGI Ref ID J:100836]

Fukuda D; Aikawa E; Swirski FK; Novobrantseva TI; Kotelianski V; Gorgun CZ; Chudnovskiy A; Yamazaki H; Croce K; Weissleder R; Aster JC; Hotamisligil GS; Yagita H; Aikawa M. 2012. Notch ligand Delta-like 4 blockade attenuates atherosclerosis and metabolic disorders. Proc Natl Acad Sci U S A 109(27):E1868-77. [PubMed: 22699504]  [MGI Ref ID J:186429]

Furbee JW Jr; Francone O; Parks JS. 2001. Alteration of plasma HDL cholesteryl ester composition with transgenic expression of a point mutation (E149A) of human LCAT. J Lipid Res 42(10):1626-35. [PubMed: 11590219]  [MGI Ref ID J:124250]

Furbee JW Jr; Francone O; Parks JS. 2002. In vivo contribution of LCAT to apolipoprotein B lipoprotein cholesteryl esters in LDL receptor and apolipoprotein E knockout mice. J Lipid Res 43(3):428-37. [PubMed: 11893779]  [MGI Ref ID J:75567]

Furbee JW Jr; Sawyer JK; Parks JS. 2002. Lecithin:cholesterol acyltransferase deficiency increases atherosclerosis in the low density lipoprotein receptor and apolipoprotein E knockout mice. J Biol Chem 277(5):3511-9. [PubMed: 11719520]  [MGI Ref ID J:74315]

Gaudreault N; Kumar N; Posada JM; Stephens KB; Reyes de Mochel NS; Eberle D; Olivas VR; Kim RY; Harms MJ; Johnson S; Messina LM; Rapp JH; Raffai RL. 2012. ApoE suppresses atherosclerosis by reducing lipid accumulation in circulating monocytes and the expression of inflammatory molecules on monocytes and vascular endothelium. Arterioscler Thromb Vasc Biol 32(2):264-72. [PubMed: 22053073]  [MGI Ref ID J:195610]

Ge S; Hertel B; Koltsova EK; Sorensen-Zender I; Kielstein JT; Ley K; Haller H; von Vietinghoff S. 2013. Increased atherosclerotic lesion formation and vascular leukocyte accumulation in renal impairment are mediated by interleukin-17A. Circ Res 113(8):965-74. [PubMed: 23908345]  [MGI Ref ID J:213467]

Gendron ME; Theoret JF; Mamarbachi AM; Drouin A; Nguyen A; Bolduc V; Thorin-Trescases N; Merhi Y; Thorin E. 2010. Late chronic catechin antioxidant treatment is deleterious to the endothelial function in aging mice with established atherosclerosis. Am J Physiol Heart Circ Physiol 298(6):H2062-70. [PubMed: 20382853]  [MGI Ref ID J:160434]

George J; Afek A; Shaish A; Levkovitz H; Bloom N; Cyrus T; Zhao L; Funk CD; Sigal E; Harats D. 2001. 12/15-Lipoxygenase gene disruption attenuates atherogenesis in LDL receptor-deficient mice. Circulation 104(14):1646-50. [PubMed: 11581143]  [MGI Ref ID J:86385]

George J; Shoenfeld Y; Harats D. 1999. The involvement of beta2-glycoprotein I (beta2-GPI) in human and murine atherosclerosis. J Autoimmun 13(1):57-60. [PubMed: 10441168]  [MGI Ref ID J:56653]

German DC; Quintero EM; Liang C; Xie C; Dietschy JM. 2001. Degeneration of neurons and glia in the Niemann-Pick C mouse is unrelated to the low-density lipoprotein receptor. Neuroscience 105(4):999-1005. [PubMed: 11530237]  [MGI Ref ID J:126474]

Gessner DK; Ringseis R; Moller C; Eder K. 2012. Increased plasma thyroid hormone concentrations in LDL receptor deficient mice may be explained by inhibition of aryl hydrocarbon receptor-dependent expression of hepatic UDP-glucuronosyltransferases. Biochim Biophys Acta 1820(4):495-502. [PubMed: 22185956]  [MGI Ref ID J:182449]

Ghazalpour A; Wang X; Lusis AJ; Mehrabian M. 2006. Complex inheritance of the 5-lipoxygenase locus influencing atherosclerosis in mice. Genetics 173(2):943-51. [PubMed: 16624897]  [MGI Ref ID J:109792]

Ghesquiere SA; Gijbels MJ; Anthonsen M; van Gorp PJ; van der Made I; Johansen B; Hofker MH; de Winther MP. 2005. Macrophage-specific overexpression of group IIa sPLA2 increases atherosclerosis and enhances collagen deposition. J Lipid Res 46(2):201-10. [PubMed: 15576846]  [MGI Ref ID J:136941]

Girod WG; Jones SP; Sieber N; Aw TY; Lefer DJ. 1999. Effects of hypercholesterolemia on myocardial ischemia-reperfusion injury in LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol 19(11):2776-81. [PubMed: 10559025]  [MGI Ref ID J:129258]

Gistera A; Robertson AK; Andersson J; Ketelhuth DF; Ovchinnikova O; Nilsson SK; Lundberg AM; Li MO; Flavell RA; Hansson GK. 2013. Transforming growth factor-beta signaling in T cells promotes stabilization of atherosclerotic plaques through an interleukin-17-dependent pathway. Sci Transl Med 5(196):196ra100. [PubMed: 23903754]  [MGI Ref ID J:213468]

Gitlin JM; Homeister JW; Bulgrien J; Counselman J; Curtiss LK; Lowe JB; Boisvert WA. 2009. Disruption of tissue-specific fucosyltransferase VII, an enzyme necessary for selectin ligand synthesis, suppresses atherosclerosis in mice. Am J Pathol 174(1):343-50. [PubMed: 19056851]  [MGI Ref ID J:144237]

Goel R; Schrank BR; Arora S; Boylan B; Fleming B; Miura H; Newman PJ; Molthen RC; Newman DK. 2008. Site-specific effects of PECAM-1 on atherosclerosis in LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol 28(11):1996-2002. [PubMed: 18669884]  [MGI Ref ID J:159801]

Goldberg IJ; Hu Y; Noh HL; Wei J; Huggins LA; Rackmill MG; Hamai H; Reid BN; Blaner WS; Huang LS. 2008. Decreased lipoprotein clearance is responsible for increased cholesterol in LDL receptor knockout mice with streptozotocin-induced diabetes. Diabetes 57(6):1674-82. [PubMed: 18346984]  [MGI Ref ID J:136922]

Goldberg IJ; Huang LS; Huggins LA; Yu S; Nagareddy PR; Scanlan TS; Ehrenkranz JR. 2012. Thyroid hormone reduces cholesterol via a non-LDL receptor-mediated pathway. Endocrinology 153(11):5143-9. [PubMed: 22948212]  [MGI Ref ID J:192913]

Gonon AT; Bulhak A; Broijersen A; Pernow J. 2005. Cardioprotective effect of an endothelin receptor antagonist during ischaemia/reperfusion in the severely atherosclerotic mouse heart. Br J Pharmacol 144(6):860-6. [PubMed: 15685207]  [MGI Ref ID J:110052]

Gonzales JC; Gordts PL; Foley EM; Esko JD. 2013. Apolipoproteins E and AV mediate lipoprotein clearance by hepatic proteoglycans. J Clin Invest 123(6):2742-51. [PubMed: 23676495]  [MGI Ref ID J:201440]

Goossens P; Gijbels MJ; Zernecke A; Eijgelaar W; Vergouwe MN; van der Made I; Vanderlocht J; Beckers L; Buurman WA; Daemen MJ; Kalinke U; Weber C; Lutgens E; de Winther MP. 2010. Myeloid type I interferon signaling promotes atherosclerosis by stimulating macrophage recruitment to lesions. Cell Metab 12(2):142-53. [PubMed: 20674859]  [MGI Ref ID J:163078]

Goossens P; Vergouwe MN; Gijbels MJ; Curfs DM; van Woezik JH; Hoeksema MA; Xanthoulea S; Leenen PJ; Rupec RA; Hofker MH; de Winther MP. 2011. Myeloid IkappaBalpha Deficiency Promotes Atherogenesis by Enhancing Leukocyte Recruitment to the Plaques. PLoS One 6(7):e22327. [PubMed: 21814576]  [MGI Ref ID J:174920]

Gordts PL; Reekmans S; Lauwers A; Van Dongen A; Verbeek L; Roebroek AJ. 2009. Inactivation of the LRP1 intracellular NPxYxxL motif in LDLR-deficient mice enhances postprandial dyslipidemia and atherosclerosis. Arterioscler Thromb Vasc Biol 29(9):1258-64. [PubMed: 19667105]  [MGI Ref ID J:167801]

Gordts SC; Van Craeyveld E; Muthuramu I; Singh N; Jacobs F; De Geest B. 2012. Lipid lowering and HDL raising gene transfer increase endothelial progenitor cells, enhance myocardial vascularity, and improve diastolic function. PLoS One 7(10):e46849. [PubMed: 23056485]  [MGI Ref ID J:191934]

Graham MJ; Lee RG; Bell TA 3rd; Fu W; Mullick AE; Alexander VJ; Singleton W; Viney N; Geary R; Su J; Baker BF; Burkey J; Crooke ST; Crooke RM. 2013. Antisense oligonucleotide inhibition of apolipoprotein C-III reduces plasma triglycerides in rodents, nonhuman primates, and humans. Circ Res 112(11):1479-90. [PubMed: 23542898]  [MGI Ref ID J:213303]

Grainger DJ; Reckless J; McKilligin E. 2004. Apolipoprotein E modulates clearance of apoptotic bodies in vitro and in vivo, resulting in a systemic proinflammatory state in apolipoprotein E-deficient mice. J Immunol 173(10):6366-75. [PubMed: 15528376]  [MGI Ref ID J:94282]

Gu L; Okada Y; Clinton SK; Gerard C; Sukhova GK; Libby P; Rollins BJ. 1998. Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice. Mol Cell 2(2):275-81. [PubMed: 9734366]  [MGI Ref ID J:75837]

Guo W; Wong S; Bhasin S. 2013. AAV-mediated administration of myostatin pro-peptide mutant in adult Ldlr null mice reduces diet-induced hepatosteatosis and arteriosclerosis. PLoS One 8(8):e71017. [PubMed: 23936482]  [MGI Ref ID J:205772]

Gupte AA; Minze LJ; Reyes M; Ren Y; Wang X; Brunner G; Ghosn M; Cordero-Reyes AM; Ding K; Pratico D; Morrisett J; Shi ZZ; Hamilton DJ; Lyon CJ; Hsueh WA. 2013. High-fat feeding-induced hyperinsulinemia increases cardiac glucose uptake and mitochondrial function despite peripheral insulin resistance. Endocrinology 154(8):2650-62. [PubMed: 23709089]  [MGI Ref ID J:201180]

Haeusler RA; Pratt-Hyatt M; Welch CL; Klaassen CD; Accili D. 2012. Impaired generation of 12-hydroxylated bile acids links hepatic insulin signaling with dyslipidemia. Cell Metab 15(1):65-74. [PubMed: 22197325]  [MGI Ref ID J:182348]

Hager L; Li L; Pun H; Liu L; Hossain MA; Maguire GF; Naples M; Baker C; Magomedova L; Tam J; Adeli K; Cummins CL; Connelly PW; Ng DS. 2012. Lecithin:cholesterol acyltransferase deficiency protects against cholesterol-induced hepatic endoplasmic reticulum stress in mice. J Biol Chem 287(24):20755-68. [PubMed: 22500017]  [MGI Ref ID J:186520]

Hamers AA; Vos M; Rassam F; Marinkovic G; Kurakula K; van Gorp PJ; de Winther MP; Gijbels MJ; de Waard V; de Vries CJ. 2012. Bone marrow-specific deficiency of nuclear receptor Nur77 enhances atherosclerosis. Circ Res 110(3):428-38. [PubMed: 22194623]  [MGI Ref ID J:192703]

Han CY; Subramanian S; Chan CK; Omer M; Chiba T; Wight TN; Chait A. 2007. Adipocyte-derived serum amyloid A3 and hyaluronan play a role in monocyte recruitment and adhesion. Diabetes 56(9):2260-73. [PubMed: 17563062]  [MGI Ref ID J:126587]

Han L; Tang MX; Ti Y; Wang ZH; Wang J; Ding WY; Wang H; Zhang Y; Zhang W; Zhong M. 2013. Overexpressing STAMP2 improves insulin resistance in diabetic ApoE(-)/(-)/LDLR(-)/(-) mice via macrophage polarization shift in adipose tissues. PLoS One 8(11):e78903. [PubMed: 24236066]  [MGI Ref ID J:209316]

Han S; Liang CP; DeVries-Seimon T; Ranalletta M; Welch CL; Collins-Fletcher K; Accili D; Tabas I; Tall AR. 2006. Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions. Cell Metab 3(4):257-66. [PubMed: 16581003]  [MGI Ref ID J:129653]

Han S; Liang CP; Westerterp M; Senokuchi T; Welch CL; Wang Q; Matsumoto M; Accili D; Tall AR. 2009. Hepatic insulin signaling regulates VLDL secretion and atherogenesis in mice. J Clin Invest 119(4):1029-41. [PubMed: 19273907]  [MGI Ref ID J:149755]

Hanna RN; Shaked I; Hubbeling HG; Punt JA; Wu R; Herrley E; Zaugg C; Pei H; Geissmann F; Ley K; Hedrick CC. 2012. NR4A1 (Nur77) deletion polarizes macrophages toward an inflammatory phenotype and increases atherosclerosis. Circ Res 110(3):416-27. [PubMed: 22194622]  [MGI Ref ID J:192704]

Harada-Shiba M; Takagi A; Marutsuka K; Moriguchi S; Yagyu H; Ishibashi S; Asada Y; Yokoyama S. 2004. Disruption of autosomal recessive hypercholesterolemia gene shows different phenotype in vitro and in vivo. Circ Res 95(9):945-52. [PubMed: 15472122]  [MGI Ref ID J:102291]

Harats D; Shaish A; George J; Mulkins M; Kurihara H; Levkovitz H; Sigal E. 2000. Overexpression of 15-lipoxygenase in vascular endothelium accelerates early atherosclerosis in LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol 20(9):2100-5. [PubMed: 10978255]  [MGI Ref ID J:127953]

Hartman HB; Lai K; Evans MJ. 2009. Loss of small heterodimer partner expression in the liver protects against dyslipidemia. J Lipid Res 50(2):193-203. [PubMed: 18820241]  [MGI Ref ID J:149005]

Hartvigsen K; Binder CJ; Hansen LF; Rafia A; Juliano J; Horkko S; Steinberg D; Palinski W; Witztum JL; Li AC. 2007. A diet-induced hypercholesterolemic murine model to study atherogenesis without obesity and metabolic syndrome. Arterioscler Thromb Vasc Biol 27(4):878-85. [PubMed: 17255537]  [MGI Ref ID J:148155]

Hasty AH; Shimano H; Osuga Ji; Namatame I; Takahashi A; Yahagi N; Perrey S; Iizuka Y; Tamura Y; Amemiya-Kudo M; Yoshikawa T; Okazaki H; Ohashi K; Harada K; Matsuzaka T; Sone H; Gotoda T; Nagai R; Ishibashi S; Yamada N. 2001. Severe hypercholesterolemia, hypertriglyceridemia, and atherosclerosis in mice lacking both leptin and the low density lipoprotein receptor. J Biol Chem 276(40):37402-8. [PubMed: 11445560]  [MGI Ref ID J:72027]

Hauer AD; Uyttenhove C; de Vos P; Stroobant V; Renauld JC; van Berkel TJ; van Snick J; Kuiper J. 2005. Blockade of interleukin-12 function by protein vaccination attenuates atherosclerosis. Circulation 112(7):1054-62. [PubMed: 16103256]  [MGI Ref ID J:117550]

Heikkila HM; Trosien J; Metso J; Jauhiainen M; Pentikainen MO; Kovanen PT; Lindstedt KA. 2010. Mast cells promote atherosclerosis by inducing both an atherogenic lipid profile and vascular inflammation. J Cell Biochem 109(3):615-23. [PubMed: 20024959]  [MGI Ref ID J:161254]

Heinonen SE; Leppanen P; Kholova I; Lumivuori H; Hakkinen SK; Bosch F; Laakso M; Yla-Herttuala S. 2007. Increased atherosclerotic lesion calcification in a novel mouse model combining insulin resistance, hyperglycemia, and hypercholesterolemia. Circ Res 101(10):1058-67. [PubMed: 17872464]  [MGI Ref ID J:141333]

Hemdahl AL; Falk E; Thoren P; Hansson GK. 2004. Thrombin inhibitor reduces myocardial infarction in apoE-/- x LDLR-/- mice. Am J Physiol Heart Circ Physiol 287(2):H872-7. [PubMed: 15031124]  [MGI Ref ID J:95598]

Hendrikx T; Bieghs V; Walenbergh SM; van Gorp PJ; Verheyen F; Jeurissen ML; Steinbusch MM; Vaes N; Binder CJ; Koek GH; Stienstra R; Netea MG; Hofker MH; Shiri-Sverdlov R. 2013. Macrophage specific caspase-1/11 deficiency protects against cholesterol crystallization and hepatic inflammation in hyperlipidemic mice. PLoS One 8(12):e78792. [PubMed: 24312444]  [MGI Ref ID J:209749]

Henninger DD; Gerritsen ME; Granger DN. 1997. Low-density lipoprotein receptor knockout mice exhibit exaggerated microvascular responses to inflammatory stimuli. Circ Res 81(2):274-81. [PubMed: 9242189]  [MGI Ref ID J:42527]

Herijgers N; Van Eck M; Korporaal SJ; Hoogerbrugge PM; Van Berkel TJ. 2000. Relative importance of the LDL receptor and scavenger receptor class B in the beta-VLDL-induced uptake and accumulation of cholesteryl esters by peritoneal macrophages J Lipid Res 41(7):1163-71. [PubMed: 10884299]  [MGI Ref ID J:63449]

Herijgers N; de Winther MP; Van Eck M; Havekes LM; Hofker MH; Hoogerbrugge PM; Van Berkel TJ. 2000. Effect of human scavenger receptor class A overexpression in bone marrow-derived cells on lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knockout mice J Lipid Res 41(9):1402-9. [PubMed: 10974047]  [MGI Ref ID J:64891]

Herz J; Qiu SQ; Oesterle A; DeSilva HV; Shafi S; Havel RJ. 1995. Initial hepatic removal of chylomicron remnants is unaffected but endocytosis is delayed in mice lacking the low density lipoprotein receptor. Proc Natl Acad Sci U S A 92(10):4611-5. [PubMed: 7753850]  [MGI Ref ID J:25195]

Hilgendorf I; Theurl I; Gerhardt LM; Robbins CS; Weber GF; Gonen A; Iwamoto Y; Degousee N; Holderried TA; Winter C; Zirlik A; Lin HY; Sukhova GK; Butany J; Rubin BB; Witztum JL; Libby P; Nahrendorf M; Weissleder R; Swirski FK. 2014. Innate response activator B cells aggravate atherosclerosis by stimulating T helper-1 adaptive immunity. Circulation 129(16):1677-87. [PubMed: 24488984]  [MGI Ref ID J:221696]

Hime NJ; Black AS; Bulgrien JJ; Curtiss LK. 2008. Leukocyte-derived hepatic lipase increases HDL and decreases en face aortic atherosclerosis in LDLr-/- mice expressing CETP. J Lipid Res 49(10):2113-23. [PubMed: 18599739]  [MGI Ref ID J:140426]

Hockings PD; Roberts T; Galloway GJ; Reid DG; Harris DA; Vidgeon-Hart M; Groot PH; Suckling KE; Benson GM. 2002. Repeated three-dimensional magnetic resonance imaging of atherosclerosis development in innominate arteries of low-density lipoprotein receptor-knockout mice. Circulation 106(13):1716-21. [PubMed: 12270868]  [MGI Ref ID J:103222]

Hoekstra M; Stitzinger M; van Wanrooij EJ; Michon IN; Kruijt JK; Kamphorst J; Van Eck M; Vreugdenhil E; Van Berkel TJ; Kuiper J. 2006. Microarray analysis indicates an important role for FABP5 and putative novel FABPs on a Western-type diet. J Lipid Res 47(10):2198-207. [PubMed: 16885566]  [MGI Ref ID J:116502]

Holdt LM; Thiery J; Breslow JL; Teupser D. 2008. Increased ADAM17 mRNA expression and activity is associated with atherosclerosis resistance in LDL-receptor deficient mice. Arterioscler Thromb Vasc Biol 28(6):1097-103. [PubMed: 18356551]  [MGI Ref ID J:149028]

Hu C; Dandapat A; Sun L; Chen J; Marwali MR; Romeo F; Sawamura T; Mehta JL. 2008. LOX-1 deletion decreases collagen accumulation in atherosclerotic plaque in low-density lipoprotein receptor knockout mice fed a high-cholesterol diet. Cardiovasc Res 79(2):287-93. [PubMed: 18453637]  [MGI Ref ID J:161897]

Hu L; Boesten LS; May P; Herz J; Bovenschen N; Huisman MV; Berbee JF; Havekes LM; van Vlijmen BJ; Tamsma JT. 2006. Macrophage low-density lipoprotein receptor-related protein deficiency enhances atherosclerosis in ApoE/LDLR double knockout mice. Arterioscler Thromb Vasc Biol 26(12):2710-5. [PubMed: 17038633]  [MGI Ref ID J:129557]

Hu L; van der Hoogt CC; Espirito Santo SM; Out R; Kypreos KE; van Vlijmen BJ; Van Berkel TJ; Romijn JA; Havekes LM; van Dijk KW; Rensen PC. 2008. The hepatic uptake of VLDL in lrp-ldlr-/-vldlr-/- mice is regulated by LPL activity and involves proteoglycans and SR-BI. J Lipid Res 49(7):1553-61. [PubMed: 18367731]  [MGI Ref ID J:138462]

Huang F; Thompson JC; Wilson PG; Aung HH; Rutledge JC; Tannock LR. 2008. Angiotensin II increases vascular proteoglycan content preceding and contributing to atherosclerosis development. J Lipid Res 49(3):521-30. [PubMed: 18033753]  [MGI Ref ID J:133289]

Huang Y; Liu XQ; Rall SC Jr; Taylor JM; von Eckardstein A; Assmann G; Mahley RW. 1998. Overexpression and accumulation of apolipoprotein E as a cause of hypertriglyceridemia. J Biol Chem 273(41):26388-93. [PubMed: 9756870]  [MGI Ref ID J:115206]

Huang Y; Rall SC Jr; Mahley RW. 1997. Genetic factors precipitating type III hyperlipoproteinemia in hypolipidemic transgenic mice expressing human apolipoprotein E2. Arterioscler Thromb Vasc Biol 17(11):2817-24. [PubMed: 9409260]  [MGI Ref ID J:45728]

Hui Y; Ricciotti E; Crichton I; Yu Z; Wang D; Stubbe J; Wang M; Pure E; FitzGerald GA. 2010. Targeted deletions of cyclooxygenase-2 and atherogenesis in mice. Circulation 121(24):2654-60. [PubMed: 20530000]  [MGI Ref ID J:178670]

Huszar D; Varban ML; Rinninger F; Feeley R; Arai T; Fairchild-Huntress V; Donovan MJ; Tall AR. 2000. Increased LDL cholesterol and atherosclerosis in LDL receptor-deficient mice with attenuated expression of scavenger receptor B1. Arterioscler Thromb Vasc Biol 20(4):1068-73. [PubMed: 10764675]  [MGI Ref ID J:62371]

Igbavboa U; Avdulov NA; Chochina SV; Wood WG. 1997. Transbilayer distribution of cholesterol is modified in brain synaptic plasma membranes of knockout mice deficient in the low-density lipoprotein receptor, apolipoprotein E, or both proteins. J Neurochem 69(4):1661-7. [PubMed: 9326295]  [MGI Ref ID J:43043]

Iqbal J; Rudel LL; Hussain MM. 2008. Microsomal triglyceride transfer protein enhances cellular cholesteryl esterification by relieving product inhibition. J Biol Chem 283(29):19967-80. [PubMed: 18502767]  [MGI Ref ID J:138737]

Ishibashi S; Brown MS; Goldstein JL; Gerard RD; Hammer RE; Herz J. 1993. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery [see comments] J Clin Invest 92(2):883-93. [PubMed: 8349823]  [MGI Ref ID J:37394]

Ishibashi S; Goldstein JL; Brown MS; Herz J; Burns DK. 1994. Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice. J Clin Invest 93(5):1885-93. [PubMed: 8182121]  [MGI Ref ID J:77012]

Ishibashi S; Hammer RE; Herz J. 1994. Asialoglycoprotein receptor deficiency in mice lacking the minor receptor subunit. J Biol Chem 269(45):27803-6. [PubMed: 7961705]  [MGI Ref ID J:21380]

Ishibashi S; Herz J; Maeda N; Goldstein JL; Brown MS. 1994. The two-receptor model of lipoprotein clearance: tests of the hypothesis in knockout mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins. Proc Natl Acad Sci U S A 91(10):4431-5. [PubMed: 8183926]  [MGI Ref ID J:18138]

Ishibashi S; Perrey S; Chen Z; Osuga Ji; Shimada M; Ohashi K; Harada K; Yazaki Y; Yamada N. 1996. Role of the low density lipoprotein (LDL) receptor pathway in the metabolism of chylomicron remnants. A quantitative study in knockout mice lacking the LDL receptor, apolipoprotein E, or both. J Biol Chem 271(37):22422-7. [PubMed: 8798405]  [MGI Ref ID J:35377]

Ishikawa K; Sugawara D; Wang Xp; Suzuki K; Itabe H; Maruyama Y; Lusis AJ. 2001. Heme oxygenase-1 inhibits atherosclerotic lesion formation in ldl-receptor knockout mice. Circ Res 88(5):506-12. [PubMed: 11249874]  [MGI Ref ID J:115392]

Iwaki T; Donahue DL; Castellino FJ. 2007. High levels of LDL-cholesterol rescue the neonatal mortality associated with afibrinogenemia in mice. J Thromb Haemost 5(3):624-6. [PubMed: 17155952]  [MGI Ref ID J:135942]

Iwaki T; Sandoval-Cooper MJ; Brechmann M; Ploplis VA; Castellino FJ. 2006. A fibrinogen deficiency accelerates the initiation of LDL cholesterol-driven atherosclerosis via thrombin generation and platelet activation in genetically predisposed mice. Blood 107(10):3883-91. [PubMed: 16434491]  [MGI Ref ID J:132734]

Jagavelu K; Tietge UJ; Gaestel M; Drexler H; Schieffer B; Bavendiek U. 2007. Systemic deficiency of the MAP kinase-activated protein kinase 2 reduces atherosclerosis in hypercholesterolemic mice. Circ Res 101(11):1104-12. [PubMed: 17885219]  [MGI Ref ID J:142788]

Jeong Ts; Schissel SL; Tabas I; Pownall HJ; Tall AR; Jiang X. 1998. Increased sphingomyelin content of plasma lipoproteins in apolipoprotein E knockout mice reflects combined production and catabolic defects and enhances reactivity with mammalian sphingomyelinase. J Clin Invest 101(4):905-12. [PubMed: 9466986]  [MGI Ref ID J:46009]

Jiang XC; Qin S; Qiao C; Kawano K; Lin M; Skold A; Xiao X; Tall AR. 2001. Apolipoprotein B secretion and atherosclerosis are decreased in mice with phospholipid-transfer protein deficiency. Nat Med 7(7):847-52. [PubMed: 11433351]  [MGI Ref ID J:70250]

Jiang XC; Tall AR; Qin S; Lin M; Schneider M; Lalanne F; Deckert V; Desrumaux C; Athias A; Witztum JL; Lagrost L. 2002. Phospholipid transfer protein deficiency protects circulating lipoproteins from oxidation due to the enhanced accumulation of vitamin E. J Biol Chem 277(35):31850-6. [PubMed: 12105225]  [MGI Ref ID J:120468]

Johansson F; Kramer F; Barnhart S; Kanter JE; Vaisar T; Merrill RD; Geng L; Oka K; Chan L; Chait A; Heinecke JW; Bornfeldt KE. 2008. Type 1 diabetes promotes disruption of advanced atherosclerotic lesions in LDL receptor-deficient mice. Proc Natl Acad Sci U S A 105(6):2082-7. [PubMed: 18252823]  [MGI Ref ID J:143961]

Johnson LA; Altenburg MK; Walzem RL; Scanga LT; Maeda N. 2008. Absence of hyperlipidemia in LDL receptor-deficient mice having apolipoprotein B100 without the putative receptor-binding sequences. Arterioscler Thromb Vasc Biol 28(10):1745-52. [PubMed: 18617647]  [MGI Ref ID J:159802]

Johnson LA; Arbones-Mainar JM; Fox RG; Pendse AA; Altenburg MK; Kim HS; Maeda N. 2011. Apolipoprotein E4 exaggerates diabetic dyslipidemia and atherosclerosis in mice lacking the LDL receptor. Diabetes 60(9):2285-94. [PubMed: 21810592]  [MGI Ref ID J:189275]

Johnson LA; Olsen RH; Merkens LS; DeBarber A; Steiner RD; Sullivan PM; Maeda N; Raber J. 2014. Apolipoprotein E-low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner. Neurobiol Dis 64:150-62. [PubMed: 24412220]  [MGI Ref ID J:211613]

Jones C; Garuti R; Michaely P; Li WP; Maeda N; Cohen JC; Herz J; Hobbs HH. 2007. Disruption of LDL but not VLDL clearance in autosomal recessive hypercholesterolemia. J Clin Invest 117(1):165-74. [PubMed: 17200716]  [MGI Ref ID J:117439]

Jones C; Hammer RE; Li WP; Cohen JC; Hobbs HH; Herz J. 2003. Normal sorting but defective endocytosis of the low density lipoprotein receptor in mice with autosomal recessive hypercholesterolemia. J Biol Chem 278(31):29024-30. [PubMed: 12746448]  [MGI Ref ID J:84694]

Jong MC; Dahlmans VE; van Gorp PJ; van Dijk KW; Breuer ML; Hofker MH; Havekes LM. 1996. In the absence of the low density lipoprotein receptor, human apolipoprotein C1 overexpression in transgenic mice inhibits the hepatic uptake of very low density lipoproteins via a receptor-associated protein-sensitive pathway. J Clin Invest 98(10):2259-67. [PubMed: 8941642]  [MGI Ref ID J:65146]

Joseph SB; McKilligin E; Pei L; Watson MA; Collins AR; Laffitte BA; Chen M; Noh G; Goodman J; Hagger GN; Tran J; Tippin TK; Wang X; Lusis AJ; Hsueh WA; Law RE; Collins JL; Willson TM; Tontonoz P. 2002. Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Proc Natl Acad Sci U S A 99(11):7604-9. [PubMed: 12032330]  [MGI Ref ID J:76860]

Joyce CW; Wagner EM; Basso F; Amar MJ; Freeman LA; Shamburek RD; Knapper CL; Syed J; Wu J; Vaisman BL; Fruchart-Najib J; Billings EM; Paigen B; Remaley AT; Santamarina-Fojo S; Brewer HB Jr. 2006. ABCA1 overexpression in the liver of LDLr-KO mice leads to accumulation of pro-atherogenic lipoproteins and enhanced atherosclerosis. J Biol Chem 281(44):33053-65. [PubMed: 16928680]  [MGI Ref ID J:117282]

Kadl A; Meher AK; Sharma PR; Lee MY; Doran AC; Johnstone SR; Elliott MR; Gruber F; Han J; Chen W; Kensler T; Ravichandran KS; Isakson BE; Wamhoff BR; Leitinger N. 2010. Identification of a novel macrophage phenotype that develops in response to atherogenic phospholipids via Nrf2. Circ Res 107(6):737-46. [PubMed: 20651288]  [MGI Ref ID J:175024]

Kanter JE; Kramer F; Barnhart S; Averill MM; Vivekanandan-Giri A; Vickery T; Li LO; Becker L; Yuan W; Chait A; Braun KR; Potter-Perigo S; Sanda S; Wight TN; Pennathur S; Serhan CN; Heinecke JW; Coleman RA; Bornfeldt KE. 2012. Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1. Proc Natl Acad Sci U S A 109(12):E715-24. [PubMed: 22308341]  [MGI Ref ID J:182631]

Kanter JE; Tang C; Oram JF; Bornfeldt KE. 2012. Acyl-CoA synthetase 1 is required for oleate and linoleate mediated inhibition of cholesterol efflux through ATP-binding cassette transporter A1 in macrophages. Biochim Biophys Acta 1821(3):358-64. [PubMed: 22020260]  [MGI Ref ID J:182368]

Kanters E; Gijbels MJ; van der Made I; Vergouwe MN; Heeringa P; Kraal G; Hofker MH; de Winther MP. 2004. Hematopoietic NF-kappaB1 deficiency results in small atherosclerotic lesions with an inflammatory phenotype. Blood 103(3):934-40. [PubMed: 14512319]  [MGI Ref ID J:87639]

Kanters E; Pasparakis M; Gijbels MJ; Vergouwe MN; Partouns-Hendriks I; Fijneman RJ; Clausen BE; Forster I; Kockx MM; Rajewsky K; Kraal G; Hofker MH; de Winther MP. 2003. Inhibition of NF-kappaB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice. J Clin Invest 112(8):1176-85. [PubMed: 14561702]  [MGI Ref ID J:86163]

Karagiannides I; Abdou R; Tzortzopoulou A; Voshol PJ; Kypreos KE. 2008. Apolipoprotein E predisposes to obesity and related metabolic dysfunctions in mice. FEBS J 275(19):4796-809. [PubMed: 18754772]  [MGI Ref ID J:142460]

Karasawa T; Takahashi A; Saito R; Sekiya M; Igarashi M; Iwasaki H; Miyahara S; Koyasu S; Nakagawa Y; Ishii K; Matsuzaka T; Kobayashi K; Yahagi N; Takekoshi K; Sone H; Yatoh S; Suzuki H; Yamada N; Shimano H. 2011. Sterol regulatory element-binding protein-1 determines plasma remnant lipoproteins and accelerates atherosclerosis in low-density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol 31(8):1788-95. [PubMed: 21546605]  [MGI Ref ID J:191862]

Karavia EA; Papachristou DJ; Kotsikogianni I; Giopanou I; Kypreos KE. 2011. Deficiency in apolipoprotein E has a protective effect on diet-induced nonalcoholic fatty liver disease in mice. FEBS J 278(17):3119-29. [PubMed: 21740524]  [MGI Ref ID J:190789]

Kassel KM; Sullivan BP; Cui W; Copple BL; Luyendyk JP. 2012. Therapeutic administration of the direct thrombin inhibitor argatroban reduces hepatic inflammation in mice with established Fatty liver disease. Am J Pathol 181(4):1287-95. [PubMed: 22841818]  [MGI Ref ID J:188704]

Kassim SH; Li H; Vandenberghe LH; Hinderer C; Bell P; Marchadier D; Wilson A; Cromley D; Redon V; Yu H; Wilson JM; Rader DJ. 2010. Gene therapy in a humanized mouse model of familial hypercholesterolemia leads to marked regression of atherosclerosis. PLoS One 5(10):e13424. [PubMed: 20976059]  [MGI Ref ID J:166224]

Katsouri L; Georgopoulos S. 2011. Lack of LDL receptor enhances amyloid deposition and decreases glial response in an Alzheimer's disease mouse model. PLoS One 6(7):e21880. [PubMed: 21755005]  [MGI Ref ID J:174945]

Kaufmann BA; Carr CL; Belcik JT; Xie A; Yue Q; Chadderdon S; Caplan ES; Khangura J; Bullens S; Bunting S; Lindner JR. 2010. Molecular imaging of the initial inflammatory response in atherosclerosis: implications for early detection of disease. Arterioscler Thromb Vasc Biol 30(1):54-9. [PubMed: 19834105]  [MGI Ref ID J:171802]

Kawashiri Ma; Zhang Y; Usher D; Reilly M; Pure E; Rader DJ. 2001. Effects of coexpression of the LDL receptor and apoE on cholesterol metabolism and atherosclerosis in LDL receptor-deficient mice. J Lipid Res 42(6):943-50. [PubMed: 11369802]  [MGI Ref ID J:69834]

Kennedy A; Gruen ML; Gutierrez DA; Surmi BK; Orr JS; Webb CD; Hasty AH. 2012. Impact of macrophage inflammatory protein-1alpha deficiency on atherosclerotic lesion formation, hepatic steatosis, and adipose tissue expansion. PLoS One 7(2):e31508. [PubMed: 22359597]  [MGI Ref ID J:185223]

Kennedy DJ; Kuchibhotla S; Westfall KM; Silverstein RL; Morton RE; Febbraio M. 2011. A CD36-dependent pathway enhances macrophage and adipose tissue inflammation and impairs insulin signalling. Cardiovasc Res 89(3):604-13. [PubMed: 21088116]  [MGI Ref ID J:186882]

Kennedy DJ; Kuchibhotla SD; Guy E; Park YM; Nimako G; Vanegas D; Morton RE; Febbraio M. 2009. Dietary cholesterol plays a role in CD36-mediated atherogenesis in LDLR-knockout mice. Arterioscler Thromb Vasc Biol 29(10):1481-7. [PubMed: 19608973]  [MGI Ref ID J:167807]

Keren P; George J; Shaish A; Levkovitz H; Janakovic Z; Afek A; Goldberg I; Kopolovic J; Keren G; Harats D. 2000. Effect of hyperglycemia and hyperlipidemia on atherosclerosis in LDL receptor-deficient mice: establishment of a combined model and association with heat shock protein 65 immunity. Diabetes 49(6):1064-9. [PubMed: 10866061]  [MGI Ref ID J:62295]

Khan OM; Akula MK; Skalen K; Karlsson C; Stahlman M; Young SG; Boren J; Bergo MO. 2013. Targeting GGTase-I activates RHOA, increases macrophage reverse cholesterol transport, and reduces atherosclerosis in mice. Circulation 127(7):782-90. [PubMed: 23334894]  [MGI Ref ID J:210275]

Kim HS; Ullevig SL; Zamora D; Lee CF; Asmis R. 2012. Redox regulation of MAPK phosphatase 1 controls monocyte migration and macrophage recruitment. Proc Natl Acad Sci U S A 109(41):E2803-12. [PubMed: 22991462]  [MGI Ref ID J:190103]

King LM; Francomano CA. 2001. Characterization of a human gene encoding nucleosomal binding protein nsbp1. Genomics 71(2):163-73. [PubMed: 11161810]  [MGI Ref ID J:67578]

King VL; Cassis LA; Daugherty A. 2007. Interleukin-4 does not influence development of hypercholesterolemia or angiotensin II-induced atherosclerotic lesions in mice. Am J Pathol 171(6):2040-7. [PubMed: 18055554]  [MGI Ref ID J:128948]

King VL; Szilvassy SJ; Daugherty A. 2002. Interleukin-4 deficiency decreases atherosclerotic lesion formation in a site-specific manner in female LDL receptor-/- mice. Arterioscler Thromb Vasc Biol 22(3):456-61. [PubMed: 11884290]  [MGI Ref ID J:103308]

King VL; Szilvassy SJ; Daugherty A. 2002. Interleukin-4 deficiency promotes gallstone formation. J Lipid Res 43(5):768-71. [PubMed: 11971948]  [MGI Ref ID J:76258]

Kinnunen K; Heinonen SE; Kalesnykas G; Laidinen S; Uusitalo-Jarvinen H; Uusitalo H; Yla-Herttuala S. 2013. LDLR-/-ApoB100/100 mice with insulin-like growth factor II overexpression reveal a novel form of retinopathy with photoreceptor atrophy and altered morphology of the retina. Mol Vis 19:1723-33. [PubMed: 23922490]  [MGI Ref ID J:205300]

Kitamoto S; Sukhova GK; Sun J; Yang M; Libby P; Love V; Duramad P; Sun C; Zhang Y; Yang X; Peters C; Shi GP. 2007. Cathepsin L deficiency reduces diet-induced atherosclerosis in low-density lipoprotein receptor-knockout mice. Circulation 115(15):2065-75. [PubMed: 17404153]  [MGI Ref ID J:135371]

Kjolby M; Andersen OM; Breiderhoff T; Fjorback AW; Pedersen KM; Madsen P; Jansen P; Heeren J; Willnow TE; Nykjaer A. 2010. Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export. Cell Metab 12(3):213-23. [PubMed: 20816088]  [MGI Ref ID J:166369]

Klingenberg R; Gerdes N; Badeau RM; Gistera A; Strodthoff D; Ketelhuth DF; Lundberg AM; Rudling M; Nilsson SK; Olivecrona G; Zoller S; Lohmann C; Luscher TF; Jauhiainen M; Sparwasser T; Hansson GK. 2013. Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis. J Clin Invest 123(3):1323-34. [PubMed: 23426179]  [MGI Ref ID J:196393]

Knouff C; Briand O; Lestavel S; Clavey V; Altenburg M; Maeda N. 2004. Defective VLDL metabolism and severe atherosclerosis in mice expressing human apolipoprotein E isoforms but lacking the LDL receptor. Biochim Biophys Acta 1684(1-3):8-17. [PubMed: 15450205]  [MGI Ref ID J:92554]

Ko KW; Paul A; Ma K; Li L; Chan L. 2005. Endothelial lipase modulates HDL but has no effect on atherosclerosis development in apoE-/- and LDLR-/- mice. J Lipid Res 46(12):2586-94. [PubMed: 16199802]  [MGI Ref ID J:106132]

Kobayashi K; Oka K; Forte T; Ishida B; Teng B; Ishimura-Oka K; Nakamuta M; Chan L. 1996. Reversal of hypercholesterolemia in low density lipoprotein receptor knockout mice by adenovirus-mediated gene transfer of the very low density lipoprotein receptor. J Biol Chem 271(12):6852-60. [PubMed: 8636110]  [MGI Ref ID J:32102]

Koltsova EK; Kim G; Lloyd KM; Saris CJ; von Vietinghoff S; Kronenberg M; Ley K. 2012. Interleukin-27 receptor limits atherosclerosis in Ldlr-/- mice. Circ Res 111(10):1274-85. [PubMed: 22927332]  [MGI Ref ID J:212625]

Kovacs A; Tornvall P; Nilsson R; Tegner J; Hamsten A; Bjorkegren J. 2007. Human C-reactive protein slows atherosclerosis development in a mouse model with human-like hypercholesterolemia. Proc Natl Acad Sci U S A 104(34):13768-73. [PubMed: 17702862]  [MGI Ref ID J:124095]

Koya T; Miyazaki T; Watanabe T; Shichiri M; Atsumi T; Kim-Kaneyama JR; Miyazaki A. 2012. Salusin-beta accelerates inflammatory responses in vascular endothelial cells via NF-kappaB signaling in LDL receptor-deficient mice in vivo and HUVECs in vitro. Am J Physiol Heart Circ Physiol 303(1):H96-105. [PubMed: 22561298]  [MGI Ref ID J:189056]

Kozarsky KF; Donahee MH; Glick JM; Krieger M; Rader DJ. 2000. Gene transfer and hepatic overexpression of the HDL receptor SR-BI reduces atherosclerosis in the cholesterol-fed LDL receptor-deficient mouse. Arterioscler Thromb Vasc Biol 20(3):721-7. [PubMed: 10712397]  [MGI Ref ID J:61288]

Kraemer FB; Shen WJ; Patel S; Osuga J; Ishibashi S; Azhar S. 2007. The LDL receptor is not necessary for acute adrenal steroidogenesis in mouse adrenocortical cells. Am J Physiol Endocrinol Metab 292(2):E408-12. [PubMed: 16985254]  [MGI Ref ID J:143674]

Krishna SM; Seto SW; Moxon JV; Rush C; Walker PJ; Norman PE; Golledge J. 2012. Fenofibrate increases high-density lipoprotein and sphingosine 1 phosphate concentrations limiting abdominal aortic aneurysm progression in a mouse model. Am J Pathol 181(2):706-18. [PubMed: 22698985]  [MGI Ref ID J:186431]

Kruit JK; Kremer PH; Dai L; Tang R; Ruddle P; de Haan W; Brunham LR; Verchere CB; Hayden MR. 2010. Cholesterol efflux via ATP-binding cassette transporter A1 (ABCA1) and cholesterol uptake via the LDL receptor influences cholesterol-induced impairment of beta cell function in mice. Diabetologia 53(6):1110-9. [PubMed: 20229095]  [MGI Ref ID J:159879]

Kubo N; Boisvert WA; Ballantyne CM; Curtiss LK. 2000. Leukocyte CD11b expression is not essential for the development of atherosclerosis in mice J Lipid Res 41(7):1060-6. [PubMed: 10884286]  [MGI Ref ID J:63447]

Kulinski A; Rustaeus S; Vance JE. 2002. Microsomal Triacylglycerol Transfer Protein Is Required for Lumenal Accretion of Triacylglycerol Not Associated with ApoB, as Well as for ApoB Lipidation. J Biol Chem 277(35):31516-25. [PubMed: 12072432]  [MGI Ref ID J:78774]

Kumar AP; Piedrafita FJ; Reynolds WF. 2004. Peroxisome proliferator-activated receptor gamma ligands regulate myeloperoxidase expression in macrophages by an estrogen-dependent mechanism involving the -463GA promoter polymorphism. J Biol Chem 279(9):8300-15. [PubMed: 14668325]  [MGI Ref ID J:130052]

Kunjathoor VV; Chiu DS; O'Brien KD; LeBoeuf RC. 2002. Accumulation of biglycan and perlecan, but not versican, in lesions of murine models of atherosclerosis. Arterioscler Thromb Vasc Biol 22(3):462-8. [PubMed: 11884291]  [MGI Ref ID J:103309]

Kwak BR; Veillard N; Pelli G; Mulhaupt F; James RW; Chanson M; Mach F. 2003. Reduced connexin43 expression inhibits atherosclerotic lesion formation in low-density lipoprotein receptor-deficient mice. Circulation 107(7):1033-9. [PubMed: 12600918]  [MGI Ref ID J:103052]

Kypreos KE; Li X; van Dijk KW; Havekes LM; Zannis VI. 2003. Molecular mechanisms of type III hyperlipoproteinemia: The contribution of the carboxy-terminal domain of ApoE can account for the dyslipidemia that is associated with the E2/E2 phenotype. Biochemistry 42(33):9841-53. [PubMed: 12924933]  [MGI Ref ID J:115687]

Kypreos KE; Zannis VI. 2006. LDL receptor deficiency or apoE mutations prevent remnant clearance and induce hypertriglyceridemia in mice. J Lipid Res 47(3):521-9. [PubMed: 16339113]  [MGI Ref ID J:107556]

Lagace TA; Curtis DE; Garuti R; McNutt MC; Park SW; Prather HB; Anderson NN; Ho YK; Hammer RE; Horton JD. 2006. Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and inlivers of parabiotic mice. J Clin Invest 116(11):2995-3005. [PubMed: 17080197]  [MGI Ref ID J:114949]

Lai CF; Seshadri V; Huang K; Shao JS; Cai J; Vattikuti R; Schumacher A; Loewy AP; Denhardt DT; Rittling SR; Towler DA. 2006. An osteopontin-NADPH oxidase signaling cascade promotes pro-matrix metalloproteinase 9 activation in aortic mesenchymal cells. Circ Res 98(12):1479-89. [PubMed: 16709900]  [MGI Ref ID J:122625]

Lambert G; Jarnoux AL; Pineau T; Pape O; Chetiveaux M; Laboisse C; Krempf M; Costet P. 2006. Fasting induces hyperlipidemia in mice overexpressing proprotein convertase subtilisin kexin type 9: lack of modulation of very-low-density lipoprotein hepatic output by the low-density lipoprotein receptor. Endocrinology 147(10):4985-95. [PubMed: 16794006]  [MGI Ref ID J:129548]

Lamharzi N; Renard CB; Kramer F; Pennathur S; Heinecke JW; Chait A; Bornfeldt KE. 2004. Hyperlipidemia in concert with hyperglycemia stimulates the proliferation of macrophages in atherosclerotic lesions: potential role of glucose-oxidized LDL. Diabetes 53(12):3217-25. [PubMed: 15561953]  [MGI Ref ID J:94609]

Lammers B; Chandak PG; Aflaki E; Van Puijvelde GH; Radovic B; Hildebrand RB; Meurs I; Out R; Kuiper J; Van Berkel TJ; Kolb D; Haemmerle G; Zechner R; Levak-Frank S; Van Eck M; Kratky D. 2011. Macrophage adipose triglyceride lipase deficiency attenuates atherosclerotic lesion development in low-density lipoprotein receptor knockout mice. Arterioscler Thromb Vasc Biol 31(1):67-73. [PubMed: 21030715]  [MGI Ref ID J:184190]

Lammers B; Zhao Y; Foks AC; Hildebrand RB; Kuiper J; Van Berkel TJ; Van Eck M. 2012. Leukocyte ABCA1 remains atheroprotective in splenectomized LDL receptor knockout mice. PLoS One 7(10):e48080. [PubMed: 23133551]  [MGI Ref ID J:192253]

Lammers B; Zhao Y; Hoekstra M; Hildebrand RB; Ye D; Meurs I; Van Berkel TJ; Van Eck M. 2011. Augmented atherogenesis in LDL receptor deficient mice lacking both macrophage ABCA1 and ApoE. PLoS One 6(10):e26095. [PubMed: 22022523]  [MGI Ref ID J:178098]

Lampropoulou A; Zannis VI; Kypreos KE. 2012. Pharmacodynamic and pharmacokinetic analysis of apoE4 [L261A, W264A, F265A, L268A, V269A], a recombinant apolipoprotein E variant with improved biological properties. Biochem Pharmacol 84(11):1451-8. [PubMed: 22985620]  [MGI Ref ID J:193572]

Langheinrich AC; Michniewicz A; Sedding DG; Walker G; Beighley PE; Rau WS; Bohle RM; Ritman EL. 2006. Correlation of vasa vasorum neovascularization and plaque progression in aortas of apolipoprotein E(-/-)/low-density lipoprotein(-/-) double knockout mice. Arterioscler Thromb Vasc Biol 26(2):347-52. [PubMed: 16293797]  [MGI Ref ID J:127960]

Larsson SL; Skogsberg J; Bjorkegren J. 2004. The low density lipoprotein receptor prevents secretion of dense apoB100-containing lipoproteins from the liver. J Biol Chem 279(2):831-6. [PubMed: 14583618]  [MGI Ref ID J:124544]

Laurila A; Cole SP; Merat S; Obonyo M; Palinski W; Fierer J; Witztum JL. 2001. High-fat, high-cholesterol diet increases the incidence of gastritis in LDL receptor-negative mice. Arterioscler Thromb Vasc Biol 21(6):991-6. [PubMed: 11397709]  [MGI Ref ID J:103300]

Lauring B; Taggart AK; Tata JR; Dunbar R; Caro L; Cheng K; Chin J; Colletti SL; Cote J; Khalilieh S; Liu J; Luo WL; Maclean AA; Peterson LB; Polis AB; Sirah W; Wu TJ; Liu X; Jin L; Wu K; Boatman PD; Semple G; Behan DP; Connolly DT; Lai E; Wagner JA; Wright SD; Cuffie C; Mitchel YB; Rader DJ; Paolini JF; Waters MG; Plump A. 2012. Niacin Lipid Efficacy Is Independent of Both the Niacin Receptor GPR109A and Free Fatty Acid Suppression. Sci Transl Med 4(148):148ra115. [PubMed: 22914621]  [MGI Ref ID J:187220]

Lee CH; Chawla A; Urbiztondo N; Liao D; Boisvert WA; Evans RM; Curtiss LK. 2003. Transcriptional repression of atherogenic inflammation: modulation by PPARdelta. Science 302(5644):453-7. [PubMed: 12970571]  [MGI Ref ID J:122915]

Lee EC; Desai U; Gololobov G; Hong S; Feng X; Yu XC; Gay J; Wilganowski N; Gao C; Du LL; Chen J; Hu Y; Zhao S; Kirkpatrick L; Schneider M; Zambrowicz BP; Landes G; Powell DR; Sonnenburg WK. 2009. Identification of a new functional domain in angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) involved in binding and inhibition of lipoprotein lipase (LPL). J Biol Chem 284(20):13735-45. [PubMed: 19318355]  [MGI Ref ID J:149912]

Lee RG; Kelley KL; Sawyer JK; Farese RV Jr; Parks JS; Rudel LL. 2004. Plasma cholesteryl esters provided by lecithin:cholesterol acyltransferase and acyl-coenzyme a:cholesterol acyltransferase 2 have opposite atherosclerotic potential. Circ Res 95(10):998-1004. [PubMed: 15486318]  [MGI Ref ID J:103854]

Lee RG; Shah R; Sawyer JK; Hamilton RL; Parks JS; Rudel LL. 2005. ACAT2 contributes cholesteryl esters to newly secreted VLDL, whereas LCAT adds cholesteryl ester to LDL in mice. J Lipid Res 46(6):1205-12. [PubMed: 15805543]  [MGI Ref ID J:128885]

Lee SJ; Grosskopf I; Choi SY; Cooper AD. 2004. Chylomicron remnant uptake in the livers of mice expressing human apolipoproteins E3, E2 (Arg158->Cys), and E3-Leiden. J Lipid Res 45(12):2199-210. [PubMed: 15466367]  [MGI Ref ID J:94176]

Lemmens KJ; van de Wier B; Koek GH; Kohler E; Drittij MJ; van der Vijgh WJ; Bast A; Haenen GR. 2015. The flavonoid monoHER promotes the adaption to oxidative stress during the onset of NAFLD. Biochem Biophys Res Commun 456(1):179-82. [PubMed: 25462563]  [MGI Ref ID J:220261]

Leppanen P; Koota S; Kholova I; Koponen J; Fieber C; Eriksson U; Alitalo K; Yla-Herttuala S. 2005. Gene transfers of vascular endothelial growth factor-A, vascular endothelial growth factor-B, vascular endothelial growth factor-C, and vascular endothelial growth factor-D have no effects on atherosclerosis in hypercholesterolemic low-density lipoprotein-receptor/apolipoprotein B48-deficient mice. Circulation 112(9):1347-52. [PubMed: 16129816]  [MGI Ref ID J:118230]

Leung VW; Yun S; Botto M; Mason JC; Malik TH; Song W; Paixao-Cavalcante D; Pickering MC; Boyle JJ; Haskard DO. 2009. Decay-accelerating factor suppresses complement C3 activation and retards atherosclerosis in low-density lipoprotein receptor-deficient mice. Am J Pathol 175(4):1757-67. [PubMed: 19729477]  [MGI Ref ID J:153060]

Levin MC; Jirholt P; Wramstedt A; Johansson ME; Lundberg AM; Trajkovska MG; Stahlman M; Fogelstrand P; Brisslert M; Fogelstrand L; Yan ZQ; Hansson GK; Bjorkbacka H; Olofsson SO; Boren J. 2011. Rip2 deficiency leads to increased atherosclerosis despite decreased inflammation. Circ Res 109(11):1210-8. [PubMed: 21959219]  [MGI Ref ID J:196562]

Lewis MJ; Malik TH; Ehrenstein MR; Boyle JJ; Botto M; Haskard DO. 2009. Immunoglobulin M is required for protection against atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation 120(5):417-26. [PubMed: 19620499]  [MGI Ref ID J:166420]

Li AC; Brown KK; Silvestre MJ; Willson TM; Palinski W; Glass CK. 2000. Peroxisome proliferator-activated receptor gamma ligands inhibit development of atherosclerosis in LDL receptor-deficient mice. J Clin Invest 106(4):523-31. [PubMed: 10953027]  [MGI Ref ID J:64040]

Li L; Hossain MA; Sadat S; Hager L; Liu L; Tam L; Schroer S; Huogen L; Fantus IG; Connelly PW; Woo M; Ng DS. 2011. Lecithin Cholesterol Acyltransferase Null Mice Are Protected from Diet-induced Obesity and Insulin Resistance in a Gender-specific Manner through Multiple Pathways. J Biol Chem 286(20):17809-20. [PubMed: 21454561]  [MGI Ref ID J:172680]

Li L; Naples M; Song H; Yuan R; Ye F; Shafi S; Adeli K; Ng DS. 2007. LCAT-null mice develop improved hepatic insulin sensitivity through altered regulation of transcription factors and suppressors of cytokine signaling. Am J Physiol Endocrinol Metab 293(2):E587-94. [PubMed: 17551001]  [MGI Ref ID J:123371]

Li L; Thompson PA; Kitchens RL. 2008. Infection induces a positive acute phase apolipoprotein E response from a negative acute phase gene: role of hepatic LDL receptors. J Lipid Res 49(8):1782-93. [PubMed: 18497424]  [MGI Ref ID J:138430]

Li R; Mittelstein D; Kam W; Pakbin P; Du Y; Tintut Y; Navab M; Sioutas C; Hsiai T. 2013. Atmospheric ultrafine particles promote vascular calcification via the NF-kappaB signaling pathway. Am J Physiol Cell Physiol 304(4):C362-9. [PubMed: 23242187]  [MGI Ref ID J:194848]

Li S; Sun Y; Liang CP; Thorp EB; Han S; Jehle AW; Saraswathi V; Pridgen B; Kanter JE; Li R; Welch CL; Hasty AH; Bornfeldt KE; Breslow JL; Tabas I; Tall AR. 2009. Defective phagocytosis of apoptotic cells by macrophages in atherosclerotic lesions of ob/ob mice and reversal by a fish oil diet. Circ Res 105(11):1072-82. [PubMed: 19834009]  [MGI Ref ID J:170144]

Li Y; Xu S; Mihaylova MM; Zheng B; Hou X; Jiang B; Park O; Luo Z; Lefai E; Shyy JY; Gao B; Wierzbicki M; Verbeuren TJ; Shaw RJ; Cohen RA; Zang M. 2011. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab 13(4):376-88. [PubMed: 21459323]  [MGI Ref ID J:172248]

Li Z; Basterr MJ; Hailemariam TK; Hojjati MR; Lu S; Liu J; Liu R; Zhou H; Jiang XC. 2005. The effect of dietary sphingolipids on plasma sphingomyelin metabolism and atherosclerosis. Biochim Biophys Acta 1735(2):130-4. [PubMed: 15967715]  [MGI Ref ID J:124540]

Lian J; Quiroga AD; Li L; Lehner R. 2012. Ces3/TGH deficiency improves dyslipidemia and reduces atherosclerosis in Ldlr(-/-) mice. Circ Res 111(8):982-90. [PubMed: 22872154]  [MGI Ref ID J:212633]

Liang CP; Han S; Li G; Tabas I; Tall AR. 2012. Impaired MEK signaling and SERCA expression promote ER stress and apoptosis in insulin-resistant macrophages and are reversed by exenatide treatment. Diabetes 61(10):2609-20. [PubMed: 22751695]  [MGI Ref ID J:208519]

Liao X; Sluimer JC; Wang Y; Subramanian M; Brown K; Pattison JS; Robbins J; Martinez J; Tabas I. 2012. Macrophage autophagy plays a protective role in advanced atherosclerosis. Cell Metab 15(4):545-53. [PubMed: 22445600]  [MGI Ref ID J:184210]

Lichtman AH; Clinton SK; Iiyama K; Connelly PW; Libby P; Cybulsky MI. 1999. Hyperlipidemia and atherosclerotic lesion development in LDL receptor-deficient mice fed defined semipurified diets with and without cholate. Arterioscler Thromb Vasc Biol 19(8):1938-44. [PubMed: 10446074]  [MGI Ref ID J:129810]

Lie J; Moerland M; van Gent T; van Haperen R; Scheek L; Sadeghi-Niaraki F; de Crom R; van Tol A. 2006. Sex differences in atherosclerosis in mice with elevated phospholipid transfer protein activity are related to decreased plasma high density lipoproteins and not to increased production of triglycerides. Biochim Biophys Acta 1761(9):1070-7. [PubMed: 16935026]  [MGI Ref ID J:116584]

Lie J; de Crom R; van Gent T; van Haperen R; Scheek L; Sadeghi-Niaraki F; van Tol A. 2004. Elevation of plasma phospholipid transfer protein increases the risk of atherosclerosis despite lower apolipoprotein B-containing lipoproteins. J Lipid Res 45(5):805-11. [PubMed: 14993244]  [MGI Ref ID J:89308]

Lieu HD; Withycombe SK; Walker Q; Rong JX; Walzem RL; Wong JS; Hamilton RL; Fisher EA; Young SG. 2003. Eliminating atherogenesis in mice by switching off hepatic lipoprotein secretion. Circulation 107(9):1315-21. [PubMed: 12628954]  [MGI Ref ID J:91722]

Lightle S; Tosheva R; Lee A; Queen-Baker J; Boyanovsky B; Shedlofsky S; Nikolova-Karakashian M. 2003. Elevation of ceramide in serum lipoproteins during acute phase response in humans and mice: role of serine-palmitoyl transferase. Arch Biochem Biophys 419(2):120-8. [PubMed: 14592455]  [MGI Ref ID J:113578]

Lillis AP; Greenlee MC; Mikhailenko I; Pizzo SV; Tenner AJ; Strickland DK; Bohlson SS. 2008. Murine low-density lipoprotein receptor-related protein 1 (LRP) is required for phagocytosis of targets bearing LRP ligands but is not required for C1q-triggered enhancement of phagocytosis. J Immunol 181(1):364-73. [PubMed: 18566402]  [MGI Ref ID J:137404]

Lim H; Kim YU; Sun H; Lee JH; Reynolds JM; Hanabuchi S; Wu H; Teng BB; Chung Y. 2014. Proatherogenic conditions promote autoimmune T helper 17 cell responses in vivo. Immunity 40(1):153-65. [PubMed: 24412615]  [MGI Ref ID J:209392]

Lim HY; Thiam CH; Yeo KP; Bisoendial R; Hii CS; McGrath KC; Tan KW; Heather A; Alexander JS; Angeli V. 2013. Lymphatic vessels are essential for the removal of cholesterol from peripheral tissues by SR-BI-mediated transport of HDL. Cell Metab 17(5):671-84. [PubMed: 23663736]  [MGI Ref ID J:199273]

Lim RS; Suhalim JL; Miyazaki-Anzai S; Miyazaki M; Levi M; Potma EO; Tromberg BJ. 2011. Identification of cholesterol crystals in plaques of atherosclerotic mice using hyperspectral CARS imaging. J Lipid Res 52(12):2177-86. [PubMed: 21949051]  [MGI Ref ID J:178544]

Lim WS; Timmins JM; Seimon TA; Sadler A; Kolodgie FD; Virmani R; Tabas I. 2008. Signal transducer and activator of transcription-1 is critical for apoptosis in macrophages subjected to endoplasmic reticulum stress in vitro and in advanced atherosclerotic lesions in vivo. Circulation 117(7):940-51. [PubMed: 18227389]  [MGI Ref ID J:145081]

Lin J; Li H; Yang M; Ren J; Huang Z; Han F; Huang J; Ma J; Zhang D; Zhang Z; Wu J; Huang D; Qiao M; Jin G; Wu Q; Huang Y; Du J; Han J. 2013. A role of RIP3-mediated macrophage necrosis in atherosclerosis development. Cell Rep 3(1):200-10. [PubMed: 23333278]  [MGI Ref ID J:196325]

Lin JZ; Martagon AJ; Hsueh WA; Baxter JD; Gustafsson JA; Webb P; Phillips KJ. 2012. Thyroid hormone receptor agonists reduce serum cholesterol independent of the LDL receptor. Endocrinology 153(12):6136-44. [PubMed: 23087171]  [MGI Ref ID J:192628]

Lingrel JB; Pilcher-Roberts R; Basford JE; Manoharan P; Neumann J; Konaniah ES; Srinivasan R; Bogdanov VY; Hui DY. 2012. Myeloid-specific Kruppel-like factor 2 inactivation increases macrophage and neutrophil adhesion and promotes atherosclerosis. Circ Res 110(10):1294-302. [PubMed: 22474254]  [MGI Ref ID J:212516]

Linton MF; Babaev VR; Gleaves LA; Fazio S. 1999. A direct role for the macrophage low density lipoprotein receptor in atherosclerotic lesion formation. J Biol Chem 274(27):19204-10. [PubMed: 10383427]  [MGI Ref ID J:56080]

Lipinski MJ; Campbell KA; Duong SQ; Welch TJ; Garmey JC; Doran AC; Skaflen MD; Oldham SN; Kelly KA; McNamara CA. 2012. Loss of Id3 increases VCAM-1 expression, macrophage accumulation, and atherogenesis in Ldlr-/- mice. Arterioscler Thromb Vasc Biol 32(12):2855-61. [PubMed: 23042815]  [MGI Ref ID J:208316]

Liu B; Li H; Repa JJ; Turley SD; Dietschy JM. 2008. Genetic variations and treatments that affect the lifespan of the NPC1 mouse. J Lipid Res 49(3):663-9. [PubMed: 18077828]  [MGI Ref ID J:133425]

Liu B; Xie C; Richardson JA; Turley SD; Dietschy JM. 2007. Receptor-mediated and bulk-phase endocytosis cause macrophage and cholesterol accumulation in Niemann-Pick C disease. J Lipid Res 48(8):1710-23. [PubMed: 17476031]  [MGI Ref ID J:123778]

Liu J; Huan C; Chakraborty M; Zhang H; Lu D; Kuo MS; Cao G; Jiang XC. 2009. Macrophage sphingomyelin synthase 2 deficiency decreases atherosclerosis in mice. Circ Res 105(3):295-303. [PubMed: 19590047]  [MGI Ref ID J:164932]

Lloyd DJ; Helmering J; Kaufman SA; Turk J; Silva M; Vasquez S; Weinstein D; Johnston B; Hale C; Veniant MM. 2011. A Volumetric Method for Quantifying Atherosclerosis in Mice by Using MicroCT: Comparison to En Face. PLoS One 6(4):e18800. [PubMed: 21533112]  [MGI Ref ID J:172393]

Lloyd DJ; McCormick J; Helmering J; Kim KW; Wang M; Fordstrom P; Kaufman SA; Lindberg RA; Veniant MM. 2008. Generation and characterization of two novel mouse models exhibiting the phenotypes of the metabolic syndrome: Apob48-/-Lepob/ob mice devoid of ApoE or Ldlr. Am J Physiol Endocrinol Metab 294(3):E496-505. [PubMed: 18160459]  [MGI Ref ID J:133453]

Lo JC; Wang Y; Tumanov AV; Bamji M; Yao Z; Reardon CA; Getz GS; Fu YX. 2007. Lymphotoxin beta receptor-dependent control of lipid homeostasis. Science 316(5822):285-8. [PubMed: 17431181]  [MGI Ref ID J:120962]

Lo Sasso G; Murzilli S; Salvatore L; D'Errico I; Petruzzelli M; Conca P; Jiang ZY; Calabresi L; Parini P; Moschetta A. 2010. Intestinal specific LXR activation stimulates reverse cholesterol transport and protects from atherosclerosis. Cell Metab 12(2):187-93. [PubMed: 20674863]  [MGI Ref ID J:163075]

Loeffler B; Heeren J; Blaeser M; Radner H; Kayser D; Aydin B; Merkel M. 2007. Lipoprotein lipase-facilitated uptake of LDL is mediated by the LDL receptor. J Lipid Res 48(2):288-98. [PubMed: 17090659]  [MGI Ref ID J:118187]

Loeper S; Asa SL; Ezzat S. 2008. Ikaros modulates cholesterol uptake: a link between tumor suppression and differentiation. Cancer Res 68(10):3715-23. [PubMed: 18483254]  [MGI Ref ID J:135021]

Lowbeer C; Forsberg AM; Tokuno S; Hemdahl AL; Gustafsson SA; Valen G. 2004. Cardiac troponin T content in heart and skeletal muscle and in blood samples from ApoE/LDL receptor double knockout mice. Clin Chim Acta 344(1-2):73-8. [PubMed: 15149873]  [MGI Ref ID J:105262]

Lu H; Boustany-Kari CM; Daugherty A; Cassis LA. 2007. Angiotensin II increases adipose angiotensinogen expression. Am J Physiol Endocrinol Metab 292(5):E1280-7. [PubMed: 17213477]  [MGI Ref ID J:121237]

Lu H; Rateri DL; Feldman DL; Jr RJ; Fukamizu A; Ishida J; Oesterling EG; Cassis LA; Daugherty A. 2008. Renin inhibition reduces hypercholesterolemia-induced atherosclerosis in mice. J Clin Invest 118(3):984-93. [PubMed: 18274671]  [MGI Ref ID J:135297]

Lu J; Cheng H; Atti E; Shih DM; Demer LL; Tintut Y. 2013. Role of paraoxonase-1 in bone anabolic effects of parathyroid hormone in hyperlipidemic mice. Biochem Biophys Res Commun 431(1):19-24. [PubMed: 23291186]  [MGI Ref ID J:198076]

Lu X; Xia M; Endresz V; Faludi I; Mundkur L; Gonczol E; Chen D; Kakkar VV. 2012. Immunization with a combination of 2 peptides derived from the C5a receptor significantly reduces early atherosclerotic lesion in Ldlr(tm1Her) Apob(tm2Sgy) J mice. Arterioscler Thromb Vasc Biol 32(10):2358-71. [PubMed: 22837469]  [MGI Ref ID J:207883]

Luchtefeld M; Grothusen C; Gagalick A; Jagavelu K; Schuett H; Tietge UJ; Pabst O; Grote K; Drexler H; Forster R; Schieffer B. 2010. Chemokine receptor 7 knockout attenuates atherosclerotic plaque development. Circulation 122(16):1621-8. [PubMed: 20921438]  [MGI Ref ID J:179485]

Ludewig B; Jaggi M; Dumrese T; Brduscha-Riem K; Odermatt B; Hengartner H; Zinkernagel RM. 2001. Hypercholesterolemia exacerbates virus-induced immunopathologic liver disease via suppression of antiviral cytotoxic T cell responses. J Immunol 166(5):3369-76. [PubMed: 11207293]  [MGI Ref ID J:126478]

Lukasova M; Malaval C; Gille A; Kero J; Offermanns S. 2011. Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells. J Clin Invest 121(3):1163-73. [PubMed: 21317532]  [MGI Ref ID J:172039]

Lundberg AM; Ketelhuth DF; Johansson ME; Gerdes N; Liu S; Yamamoto M; Akira S; Hansson GK. 2013. Toll-like receptor 3 and 4 signalling through the TRIF and TRAM adaptors in haematopoietic cells promotes atherosclerosis. Cardiovasc Res 99(2):364-73. [PubMed: 23417039]  [MGI Ref ID J:218663]

Luo N; Liu J; Chung BH; Yang Q; Klein RL; Garvey WT; Fu Y. 2010. Macrophage adiponectin expression improves insulin sensitivity and protects against inflammation and atherosclerosis. Diabetes 59(4):791-9. [PubMed: 20350970]  [MGI Ref ID J:164323]

Lutgens E; Lievens D; Beckers L; Wijnands E; Soehnlein O; Zernecke A; Seijkens T; Engel D; Cleutjens J; Keller AM; Naik SH; Boon L; Oufella HA; Mallat Z; Ahonen CL; Noelle RJ; de Winther MP; Daemen MJ; Biessen EA; Weber C. 2010. Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile. J Exp Med 207(2):391-404. [PubMed: 20100871]  [MGI Ref ID J:157760]

Ma Y; Wang W; Zhang J; Lu Y; Wu W; Yan H; Wang Y. 2012. Hyperlipidemia and atherosclerotic lesion development in Ldlr-deficient mice on a long-term high-fat diet. PLoS One 7(4):e35835. [PubMed: 22558236]  [MGI Ref ID J:187279]

MacArthur JM; Bishop JR; Stanford KI; Wang L; Bensadoun A; Witztum JL; Esko JD. 2007. Liver heparan sulfate proteoglycans mediate clearance of triglyceride-rich lipoproteins independently of LDL receptor family members. J Clin Invest 117(1):153-64. [PubMed: 17200715]  [MGI Ref ID J:117455]

MacDonald ML; Singaraja RR; Bissada N; Ruddle P; Watts R; Karasinska JM; Gibson WT; Fievet C; Vance JE; Staels B; Hayden MR. 2008. Absence of stearoyl-CoA desaturase-1 ameliorates features of the metabolic syndrome in LDLR-deficient mice. J Lipid Res 49(1):217-29. [PubMed: 17960025]  [MGI Ref ID J:130278]

MacDonald ML; van Eck M; Hildebrand RB; Wong BW; Bissada N; Ruddle P; Kontush A; Hussein H; Pouladi MA; Chapman MJ; Fievet C; van Berkel TJ; Staels B; McManus BM; Hayden MR. 2009. Despite antiatherogenic metabolic characteristics, SCD1-deficient mice have increased inflammation and atherosclerosis. Arterioscler Thromb Vasc Biol 29(3):341-7. [PubMed: 19095997]  [MGI Ref ID J:160858]

MacDougall ED; Kramer F; Polinsky P; Barnhart S; Askari B; Johansson F; Varon R; Rosenfeld ME; Oka K; Chan L; Schwartz SM; Bornfeldt KE. 2006. Aggressive very low-density lipoprotein (VLDL) and LDL lowering by gene transfer of the VLDL receptor combined with a low-fat diet regimen induces regression and reduces macrophage content in advanced atherosclerotic lesions in LDL receptor-deficient mice. Am J Pathol 168(6):2064-73. [PubMed: 16723719]  [MGI Ref ID J:109123]

Mach F; Sukhova GK; Michetti M; Libby P; Michetti P. 2002. Influence of Helicobacter pylori infection during atherogenesis in vivo in mice. Circ Res 90(1):E1-4. [PubMed: 11786527]  [MGI Ref ID J:109711]

Machado RM; Stefano JT; Oliveira CP; Mello ES; Ferreira FD; Nunes VS; de Lima VM; Quintao EC; Catanozi S; Nakandakare ER; Lottenberg AM. 2010. Intake of trans fatty acids causes nonalcoholic steatohepatitis and reduces adipose tissue fat content. J Nutr 140(6):1127-32. [PubMed: 20357081]  [MGI Ref ID J:160756]

Madenspacher JH; Draper DW; Smoak KA; Li H; Griffiths GL; Suratt BT; Wilson MD; Rudel LL; Fessler MB. 2010. Dyslipidemia induces opposing effects on intrapulmonary and extrapulmonary host defense through divergent TLR response phenotypes. J Immunol 185(3):1660-9. [PubMed: 20581153]  [MGI Ref ID J:162471]

Maganto-Garcia E; Tarrio ML; Grabie N; Bu DX; Lichtman AH. 2011. Dynamic changes in regulatory T cells are linked to levels of diet-induced hypercholesterolemia. Circulation 124(2):185-95. [PubMed: 21690490]  [MGI Ref ID J:186295]

Major AS; Fazio S; Linton MF. 2002. B-lymphocyte deficiency increases atherosclerosis in LDL receptor-null mice. Arterioscler Thromb Vasc Biol 22(11):1892-8. [PubMed: 12426221]  [MGI Ref ID J:103218]

Malik TH; Cortini A; Carassiti D; Boyle JJ; Haskard DO; Botto M. 2010. The alternative pathway is critical for pathogenic complement activation in endotoxin- and diet-induced atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation 122(19):1948-56. [PubMed: 20974996]  [MGI Ref ID J:179480]

Mallat Z; Gojova A; Sauzeau V; Brun V; Silvestre JS; Esposito B; Merval R; Groux H; Loirand G; Tedgui A. 2003. Rho-associated protein kinase contributes to early atherosclerotic lesion formation in mice. Circ Res 93(9):884-8. [PubMed: 14525807]  [MGI Ref ID J:115653]

Malloy SI; Altenburg MK; Knouff C; Lanningham-Foster L; Parks JS; Maeda N. 2004. Harmful effects of increased LDLR expression in mice with human APOE*4 but not APOE*3. Arterioscler Thromb Vasc Biol 24(1):91-7. [PubMed: 12969990]  [MGI Ref ID J:146721]

Marquart TJ; Wu J; Lusis AJ; Baldan A. 2013. Anti-miR-33 therapy does not alter the progression of atherosclerosis in low-density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol 33(3):455-8. [PubMed: 23288159]  [MGI Ref ID J:216897]

Marsh MM; Walker VR; Curtiss LK; Banka CL. 1999. Protection against atherosclerosis by estrogen is independent of plasma cholesterol levels in LDL receptor-deficient mice. J Lipid Res 40(5):893-900. [PubMed: 10224158]  [MGI Ref ID J:54588]

Martens GW; Vallerskog T; Kornfeld H. 2012. Hypercholesterolemic LDL receptor-deficient mice mount a neutrophilic response to tuberculosis despite the timely expression of protective immunity. J Leukoc Biol 91(6):849-57. [PubMed: 22227965]  [MGI Ref ID J:184951]

Martins IJ; Hone E; Chi C; Seydel U; Martins RN; Redgrave TG. 2000. Relative roles of LDLr and LRP in the metabolism of chylomicron remnants in genetically manipulated mice. J Lipid Res 41(2):205-13. [PubMed: 10681404]  [MGI Ref ID J:120545]

Masucci-Magoulas L; Goldberg IJ; Bisgaier CL; Serajuddin H; Francone OL ; Breslow JL ; Tall AR. 1997. A mouse model with features of familial combined hyperlipidemia. Science 275(5298):391-4. [PubMed: 8994037]  [MGI Ref ID J:37861]

Masucci-Magoulas L; Plump A; Jiang XC; Walsh A; Breslow JL; Tall AR. 1996. Profound induction of hepatic cholesteryl ester transfer protein transgene expression in apolipoprotein E and low density lipoprotein receptor gene knockout mice. A novel mechanism signals changes in plasma cholesterol levels. J Clin Invest 97(1):154-61. [PubMed: 8550828]  [MGI Ref ID J:111394]

Matasconi M; Parini P; Angelin B; Rudling M. 2005. Pituitary control of cholesterol metabolism in normal and LDL receptor knock-out mice: effects of hypophysectomy and growth hormone treatment. Biochim Biophys Acta 1736(3):221-7. [PubMed: 16185916]  [MGI Ref ID J:102525]

Matt U; Sharif O; Martins R; Furtner T; Langeberg L; Gawish R; Elbau I; Zivkovic A; Lakovits K; Oskolkova O; Doninger B; Vychytil A; Perkmann T; Schabbauer G; Binder CJ; Bochkov VN; Scott JD; Knapp S. 2013. WAVE1 mediates suppression of phagocytosis by phospholipid-derived DAMPs. J Clin Invest 123(7):3014-24. [PubMed: 23934128]  [MGI Ref ID J:201609]

Matthijsen RA; de Winther MP; Kuipers D; van der Made I; Weber C; Herias MV; Gijbels MJ; Buurman WA. 2009. Macrophage-specific expression of mannose-binding lectin controls atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation 119(16):2188-95. [PubMed: 19380618]  [MGI Ref ID J:166493]

McCaffrey TA; Fu C; Du B; Eksinar S; Kent KC; Bush H Jr; Kreiger K; Rosengart T; Cybulsky MI; Silverman ES; Collins T. 2000. High-level expression of Egr-1 and Egr-1-inducible genes in mouse and human atherosclerosis [see comments] J Clin Invest 105(5):653-62. [PubMed: 10712437]  [MGI Ref ID J:60968]

McGillicuddy CJ; Carrier MJ; Weinberg PD. 2001. Distribution of lipid deposits around aortic branches of mice lacking LDL receptors and apolipoprotein E. Arterioscler Thromb Vasc Biol 21(7):1220-5. [PubMed: 11451755]  [MGI Ref ID J:103203]

McMillen TS; Heinecke JW; LeBoeuf RC. 2005. Expression of human myeloperoxidase by macrophages promotes atherosclerosis in mice. Circulation 111(21):2798-804. [PubMed: 15911707]  [MGI Ref ID J:112270]

Mehrabian M; Allayee H; Wong J; Shi W; Wang XP; Shaposhnik Z; Funk CD; Lusis AJ. 2002. Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice. Circ Res 91(2):120-6. [PubMed: 12142344]  [MGI Ref ID J:109703]

Mehta JL; Sanada N; Hu CP; Chen J; Dandapat A; Sugawara F; Satoh H; Inoue K; Kawase Y; Jishage K; Suzuki H; Takeya M; Schnackenberg L; Beger R; Hermonat PL; Thomas M; Sawamura T. 2007. Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol diet. Circ Res 100(11):1634-42. [PubMed: 17478727]  [MGI Ref ID J:130794]

Meiler S; Baumer Y; Huang Z; Hoffmann FW; Fredericks GJ; Rose AH; Norton RL; Hoffmann PR; Boisvert WA. 2013. Selenoprotein K is required for palmitoylation of CD36 in macrophages: implications in foam cell formation and atherogenesis. J Leukoc Biol 93(5):771-80. [PubMed: 23444136]  [MGI Ref ID J:200795]

Melchior JT; Sawyer JK; Kelley KL; Shah R; Wilson MD; Hantgan RR; Rudel LL. 2013. LDL particle core enrichment in cholesteryl oleate increases proteoglycan binding and promotes atherosclerosis. J Lipid Res 54(9):2495-503. [PubMed: 23804810]  [MGI Ref ID J:200774]

Merat S; Casanada F; Sutphin M; Palinski W; Reaven PD. 1999. Western-type diets induce insulin resistance and hyperinsulinemia in LDL receptor-deficient mice but do not increase aortic atherosclerosis compared with normoinsulinemic mice in which similar plasma cholesterol levels are achieved by a fructose-rich diet. Arterioscler Thromb Vasc Biol 19(5):1223-30. [PubMed: 10323773]  [MGI Ref ID J:103205]

Merat S; Fruebis J; Sutphin M; Silvestre M; Reaven PD. 2000. Effect of aging on aortic expression of the vascular cell adhesion molecule-1 and atherosclerosis in murine models of atherosclerosis. J Gerontol A Biol Sci Med Sci 55(2):B85-94. [PubMed: 10737683]  [MGI Ref ID J:61164]

Merched A; Tollefson K; Chan L. 2010. Beta2 integrins modulate the initiation and progression of atherosclerosis in low-density lipoprotein receptor knockout mice. Cardiovasc Res 85(4):853-63. [PubMed: 19843511]  [MGI Ref ID J:172548]

Merkel M; Velez-Carrasco W; Hudgins LC; Breslow JL. 2001. Compared with saturated fatty acids, dietary monounsaturated fatty acids and carbohydrates increase atherosclerosis and VLDL cholesterol levels in LDL receptor-deficient, but not apolipoprotein E-deficient, mice. Proc Natl Acad Sci U S A 98(23):13294-9. [PubMed: 11606787]  [MGI Ref ID J:72580]

Methia N; Andre P; Denis CV; Economopoulos M; Wagner DD. 2001. Localized reduction of atherosclerosis in von Willebrand factor-deficient mice. Blood 98(5):1424-8. [PubMed: 11520791]  [MGI Ref ID J:106677]

Meurs I; Calpe-Berdiel L; Habets KL; Zhao Y; Korporaal SJ; Mommaas AM; Josselin E; Hildebrand RB; Ye D; Out R; Kuiper J; Van Berkel TJ; Chimini G; Van Eck M. 2012. Effects of deletion of macrophage ABCA7 on lipid metabolism and the development of atherosclerosis in the presence and absence of ABCA1. PLoS One 7(3):e30984. [PubMed: 22403608]  [MGI Ref ID J:186854]

Meyer JM; Ji A; Cai L; van der Westhuyzen DR. 2014. Minimally oxidized LDL inhibits macrophage selective cholesteryl ester uptake and native LDL-induced foam cell formation. J Lipid Res 55(8):1648-1656. [PubMed: 24891335]  [MGI Ref ID J:214992]

Mihara K; Spansier M; Rooseboom M; Smit MJ; Dokter W. 2007. Functional replacement of murine CXCR2 by its human homologue in the development of atherosclerosis in LDLR knockout mice. Biol Pharm Bull 30(7):1231-6. [PubMed: 17603159]  [MGI Ref ID J:124372]

Milanski M; Arruda AP; Coope A; Ignacio-Souza LM; Nunez CE; Roman EA; Romanatto T; Pascoal LB; Caricilli AM; Torsoni MA; Prada PO; Saad MJ; Velloso LA. 2012. Inhibition of hypothalamic inflammation reverses diet-induced insulin resistance in the liver. Diabetes 61(6):1455-62. [PubMed: 22522614]  [MGI Ref ID J:196822]

Millar JS; Maugeais C; Fuki IV; Rader DJ. 2002. Normal production rate of apolipoprotein B in LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol 22(6):989-94. [PubMed: 12067909]  [MGI Ref ID J:103299]

Miller JD; Chu Y; Castaneda LE; Serrano KM; Brooks RM; Heistad DD. 2013. Vascular function during prolonged progression and regression of atherosclerosis in mice. Arterioscler Thromb Vasc Biol 33(3):459-65. [PubMed: 23307875]  [MGI Ref ID J:216887]

Miller JD; Weiss RM; Serrano KM; Brooks RM 2nd; Berry CJ; Zimmerman K; Young SG; Heistad DD. 2009. Lowering plasma cholesterol levels halts progression of aortic valve disease in mice. Circulation 119(20):2693-701. [PubMed: 19433756]  [MGI Ref ID J:166428]

Minahk C; Kim KW; Nelson R; Trigatti B; Lehner R; Vance DE. 2008. Conversion of low density lipoprotein-associated phosphatidylcholine to triacylglycerol by primary hepatocytes. J Biol Chem 283(10):6449-58. [PubMed: 18175806]  [MGI Ref ID J:133757]

Missiou A; Kostlin N; Varo N; Rudolf P; Aichele P; Ernst S; Munkel C; Walter C; Stachon P; Sommer B; Pfeifer D; Zirlik K; MacFarlane L; Wolf D; Tsitsikov E; Bode C; Libby P; Zirlik A. 2010. Tumor necrosis factor receptor-associated factor 1 (TRAF1) deficiency attenuates atherosclerosis in mice by impairing monocyte recruitment to the vessel wall. Circulation 121(18):2033-44. [PubMed: 20421522]  [MGI Ref ID J:172624]

Missiou A; Rudolf P; Stachon P; Wolf D; Varo N; Aichele P; Colberg C; Hoppe N; Ernst S; Munkel C; Walter C; Sommer B; Hilgendorf I; Nakano H; Bode C; Zirlik A. 2010. TRAF5 deficiency accelerates atherogenesis in mice by increasing inflammatory cell recruitment and foam cell formation. Circ Res 107(6):757-66. [PubMed: 20651286]  [MGI Ref ID J:175026]

Mitchell PL; Karakach TK; Currie DL; McLeod RS. 2012. t-10, c-12 CLA dietary supplementation inhibits atherosclerotic lesion development despite adverse cardiovascular and hepatic metabolic marker profiles. PLoS One 7(12):e52634. [PubMed: 23285120]  [MGI Ref ID J:195756]

Miyazaki T; Taketomi Y; Takimoto M; Lei XF; Arita S; Kim-Kaneyama JR; Arata S; Ohata H; Ota H; Murakami M; Miyazaki A. 2011. m-Calpain induction in vascular endothelial cells on human and mouse atheromas and its roles in VE-cadherin disorganization and atherosclerosis. Circulation 124(23):2522-32. [PubMed: 22064597]  [MGI Ref ID J:193805]

Moerland M; Samyn H; van Gent T; Jauhiainen M; Metso J; van Haperen R; Grosveld F; van Tol A; de Crom R. 2007. Atherogenic, enlarged, and dysfunctional HDL in human PLTP/apoA-I double transgenic mice. J Lipid Res 48(12):2622-31. [PubMed: 17761633]  [MGI Ref ID J:129970]

Moerland M; Samyn H; van Gent T; van Haperen R; Dallinga-Thie G; Grosveld F; van Tol A; de Crom R. 2008. Acute elevation of plasma PLTP activity strongly increases pre-existing atherosclerosis. Arterioscler Thromb Vasc Biol 28(7):1277-82. [PubMed: 18421000]  [MGI Ref ID J:159813]

Mollmark J; Ravi S; Sun B; Shipman S; Buitendijk M; Simons M; Mulligan-Kehoe MJ. 2011. Antiangiogenic activity of rPAI-1(23) promotes vasa vasorum regression in hypercholesterolemic mice through a plasmin-dependent mechanism. Circ Res 108(12):1419-28. [PubMed: 21546607]  [MGI Ref ID J:185688]

Mollmark JI; Park AJ; Kim J; Wang TZ; Katzenell S; Shipman SL; Zagorchev LG; Simons M; Mulligan-Kehoe MJ. 2012. Fibroblast growth factor-2 is required for vasa vasorum plexus stability in hypercholesterolemic mice. Arterioscler Thromb Vasc Biol 32(11):2644-51. [PubMed: 22982464]  [MGI Ref ID J:207880]

Mooij HL; Bernelot Moens SJ; Gordts PL; Stanford KI; Foley EM; van den Boogert MA; Witjes JJ; Hassing HC; Tanck MW; van de Sande MA; Levels JH; Kastelein JJ; Stroes ES; Dallinga-Thie GM; Esko JD; Nieuwdorp M. 2015. Ext1 heterozygosity causes a modest effect on postprandial lipid clearance in humans. J Lipid Res 56(3):665-73. [PubMed: 25568062]  [MGI Ref ID J:220029]

Moore RE; Navab M; Millar JS; Zimetti F; Hama S; Rothblat GH; Rader DJ. 2005. Increased atherosclerosis in mice lacking apolipoprotein A-I attributable to both impaired reverse cholesterol transport and increased inflammation. Circ Res 97(8):763-71. [PubMed: 16151025]  [MGI Ref ID J:114636]

Moreira EL; Aguiar AS Jr; de Carvalho CR; Santos DB; de Oliveira J; de Bem AF; Xikota JC; Walz R; Farina M; Prediger RD. 2013. Effects of lifestyle modifications on cognitive impairments in a mouse model of hypercholesterolemia. Neurosci Lett 541:193-8. [PubMed: 23470631]  [MGI Ref ID J:199546]

Moreira EL; de Oliveira J; Dutra MF; Santos DB; Goncalves CA; Goldfeder EM; de Bem AF; Prediger RD; Aschner M; Farina M. 2012. Does methylmercury-induced hypercholesterolemia play a causal role in its neurotoxicity and cardiovascular disease? Toxicol Sci 130(2):373-82. [PubMed: 22903822]  [MGI Ref ID J:192657]

Mori N; Horie Y; Nimura Y; Wolf R; Granger DN. 2000. Hepatic microvascular responses to ischemia-reperfusion in low-density lipoprotein receptor knockout mice. Am J Physiol Gastrointest Liver Physiol 279(6):G1257-64. [PubMed: 11093949]  [MGI Ref ID J:108060]

Mortimer BC; Beveridge DJ; Martins IJ; Redgrave TG. 1995. Intracellular localization and metabolism of chylomicron remnants in the livers of low density lipoprotein receptor-deficient mice and apoE-deficient mice. Evidence for slow metabolism via an alternative apoE-dependent pathway. J Biol Chem 270(48):28767-76. [PubMed: 7499399]  [MGI Ref ID J:29909]

Mulder M; Jansen PJ; Janssen BJ; van de Berg WD; van der Boom H; Havekes LM; de Kloet RE; Ramaekers FC; Blokland A. 2004. Low-density lipoprotein receptor-knockout mice display impaired spatial memory associated with a decreased synaptic density in the hippocampus. Neurobiol Dis 16(1):212-9. [PubMed: 15207278]  [MGI Ref ID J:120389]

Mulder M; Koopmans G; Wassink G; Al Mansouri G; Simard ML; Havekes LM; Prickaerts J; Blokland A. 2007. LDL receptor deficiency results in decreased cell proliferation and presynaptic bouton density in the murine hippocampus. Neurosci Res 59(3):251-6. [PubMed: 17720268]  [MGI Ref ID J:127270]

Mullick AE; Fu W; Graham MJ; Lee RG; Witchell D; Bell TA; Whipple CP; Crooke RM. 2011. Antisense oligonucleotide reduction of apoB-ameliorated atherosclerosis in LDL receptor-deficient mice. J Lipid Res 52(5):885-96. [PubMed: 21343632]  [MGI Ref ID J:180930]

Mullick AE; Soldau K; Kiosses WB; Bell TA 3rd; Tobias PS; Curtiss LK. 2008. Increased endothelial expression of Toll-like receptor 2 at sites of disturbed blood flow exacerbates early atherogenic events. J Exp Med 205(2):373-83. [PubMed: 18250194]  [MGI Ref ID J:131783]

Mullick AE; Tobias PS; Curtiss LK. 2005. Modulation of atherosclerosis in mice by Toll-like receptor 2. J Clin Invest 115(11):3149-56. [PubMed: 16211093]  [MGI Ref ID J:102502]

Mulvihill EE; Allister EM; Sutherland BG; Telford DE; Sawyez CG; Edwards JY; Markle JM; Hegele RA; Huff MW. 2009. Naringenin prevents dyslipidemia, apolipoprotein B overproduction, and hyperinsulinemia in LDL receptor-null mice with diet-induced insulin resistance. Diabetes 58(10):2198-210. [PubMed: 19592617]  [MGI Ref ID J:154397]

Mulvihill EE; Assini JM; Lee JK; Allister EM; Sutherland BG; Koppes JB; Sawyez CG; Edwards JY; Telford DE; Charbonneau A; St-Pierre P; Marette A; Huff MW. 2011. Nobiletin Attenuates VLDL Overproduction, Dyslipidemia, and Atherosclerosis in Mice With Diet-Induced Insulin Resistance. Diabetes 60(5):1446-57. [PubMed: 21471511]  [MGI Ref ID J:171813]

Mundkur L; Mukhopadhyay R; Samson S; Varma M; Kale D; Chen D; Shivaprasad S; Sivanandan H; Soman V; Lu X; Kakkar VV. 2013. Mucosal tolerance to a combination of ApoB and HSP60 peptides controls plaque progression and stabilizes vulnerable plaque in Apob(tm2Sgy)Ldlr(tm1Her)/J mice. PLoS One 8(3):e58364. [PubMed: 23505495]  [MGI Ref ID J:199840]

Muratoglu SC; Belgrave S; Lillis AP; Migliorini M; Robinson S; Smith E; Zhang L; Strickland DK. 2011. Macrophage LRP1 suppresses neo-intima formation during vascular remodeling by modulating the TGF-beta signaling pathway. PLoS One 6(12):e28846. [PubMed: 22174911]  [MGI Ref ID J:182253]

Murphy AJ; Akhtari M; Tolani S; Pagler T; Bijl N; Kuo CL; Wang M; Sanson M; Abramowicz S; Welch C; Bochem AE; Kuivenhoven JA; Yvan-Charvet L; Tall AR. 2011. ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in mice. J Clin Invest 121(10):4138-49. [PubMed: 21968112]  [MGI Ref ID J:178453]

Murphy AJ; Bijl N; Yvan-Charvet L; Welch CB; Bhagwat N; Reheman A; Wang Y; Shaw JA; Levine RL; Ni H; Tall AR; Wang N. 2013. Cholesterol efflux in megakaryocyte progenitors suppresses platelet production and thrombocytosis. Nat Med 19(5):586-94. [PubMed: 23584088]  [MGI Ref ID J:198517]

Nagareddy PR; Murphy AJ; Stirzaker RA; Hu Y; Yu S; Miller RG; Ramkhelawon B; Distel E; Westerterp M; Huang LS; Schmidt AM; Orchard TJ; Fisher EA; Tall AR; Goldberg IJ. 2013. Hyperglycemia promotes myelopoiesis and impairs the resolution of atherosclerosis. Cell Metab 17(5):695-708. [PubMed: 23663738]  [MGI Ref ID J:199272]

Naik SU; Wang X; Da Silva JS; Jaye M; Macphee CH; Reilly MP; Billheimer JT; Rothblat GH; Rader DJ. 2006. Pharmacological activation of liver X receptors promotes reverse cholesterol transport in vivo. Circulation 113(1):90-7. [PubMed: 16365197]  [MGI Ref ID J:121508]

Nakai Y; Iwabuchi K; Fujii S; Ishimori N; Dashtsoodol N; Watano K; Mishima T; Iwabuchi C; Tanaka S; Bezbradica JS; Nakayama T; Taniguchi M; Miyake S; Yamamura T; Kitabatake A; Joyce S; Van Kaer L; Onoe K. 2004. Natural killer T cells accelerate atherogenesis in mice. Blood 104(7):2051-9. [PubMed: 15113755]  [MGI Ref ID J:93754]

Nakamura I; Hasegawa K; Wada Y; Hirase T; Node K; Watanabe Y. 2013. Detection of early stage atherosclerotic plaques using PET and CT fusion imaging targeting P-selectin in low density lipoprotein receptor-deficient mice. Biochem Biophys Res Commun 433(1):47-51. [PubMed: 23485468]  [MGI Ref ID J:201227]

Nakamura T; Ruiz-Lozano P; Lindner V; Yabe D; Taniwaki M; Furukawa Y; Kobuke K; Tashiro K; Lu Z; Andon NL; Schaub R; Matsumori A; Sasayama S; Chien KR; Honjo T. 1999. DANCE, a novel secreted RGD protein expressed in developing, atherosclerotic, and balloon-injured arteries. J Biol Chem 274(32):22476-83. [PubMed: 10428823]  [MGI Ref ID J:56624]

Nakamuta M; Taniguchi S; Ishida BY; Kobayashi K; Chan L. 1998. Phenotype interaction of apobec-1 and CETP, LDLR, and apoE gene expression in mice: role of apoB mRNA editing in lipoprotein phenotype expression. Arterioscler Thromb Vasc Biol 18(5):747-55. [PubMed: 9598833]  [MGI Ref ID J:48202]

Nakaya H; Summers BD; Nicholson AC; Gotto AM Jr; Hajjar DP; Han J. 2009. Atherosclerosis in LDLR-knockout mice is inhibited, but not reversed, by the PPARgamma ligand pioglitazone. Am J Pathol 174(6):2007-14. [PubMed: 19435790]  [MGI Ref ID J:148764]

Nassir F; Xie Y; Patterson BW; Luo J; Davidson NO. 2004. Hepatic secretion of small lipoprotein particles in apobec-1-/- mice is regulated by the LDL receptor. J Lipid Res 45(9):1649-59. [PubMed: 15145984]  [MGI Ref ID J:121192]

Nathan L; Shi W; Dinh H; Mukherjee TK; Wang X; Lusis AJ; Chaudhuri G. 2001. Testosterone inhibits early atherogenesis by conversion to estradiol: critical role of aromatase. Proc Natl Acad Sci U S A 98(6):3589-93. [PubMed: 11248122]  [MGI Ref ID J:80921]

Navab M; Hama-Levy S; Van Lenten BJ; Fonarow GC; Cardinez CJ ; Castellani LW ; Brennan ML ; Lusis AJ ; Fogelman AM ; La Du BN. 1997. Mildly oxidized LDL induces an increased apolipoprotein J/paraoxonase ratio [published erratum appears in J Clin Invest 1997 Jun 15;99(12):3043] J Clin Invest 99(8):2005-19. [PubMed: 9109446]  [MGI Ref ID J:40285]

Nawrocki AR; Hofmann SM; Teupser D; Basford JE; Durand JL; Jelicks LA; Woo CW; Kuriakose G; Factor SM; Tanowitz HB; Hui DY; Tabas I; Scherer PE. 2010. Lack of association between adiponectin levels and atherosclerosis in mice. Arterioscler Thromb Vasc Biol 30(6):1159-65. [PubMed: 20299691]  [MGI Ref ID J:180866]

Netea MG; Demacker PN; Kullberg BJ; Boerman OC; Verschueren I; Stalenhoef AF; van der Meer JW. 1996. Low-density lipoprotein receptor-deficient mice are protected against lethal endotoxemia and severe gram-negative infections. J Clin Invest 97(6):1366-72. [PubMed: 8617867]  [MGI Ref ID J:31997]

Netea MG; Joosten LA; Keuter M; Wagener F; Stalenhoef AF; van der Meer JW; Kullberg BJ. 2009. Circulating lipoproteins are a crucial component of host defense against invasive Salmonella typhimurium infection. PLoS ONE 4(1):e4237. [PubMed: 19156198]  [MGI Ref ID J:144972]

Ng DS; Xie C; Maguire GF; Zhu X; Ugwu F; Lam E; Connelly PW. 2004. Hypertriglyceridemia in lecithin-cholesterol acyltransferase-deficient mice is associated with hepatic overproduction of triglycerides, increased lipogenesis, and improved glucose tolerance. J Biol Chem 279(9):7636-42. [PubMed: 14668345]  [MGI Ref ID J:89015]

Ngai YF; Quong WL; Glier MB; Glavas MM; Babich SL; Innis SM; Kieffer TJ; Gibson WT. 2010. Ldlr-/- mice display decreased susceptibility to Western-type diet-induced obesity due to increased thermogenesis. Endocrinology 151(11):5226-36. [PubMed: 20881250]  [MGI Ref ID J:168347]

Nishizawa T; Kanter JE; Kramer F; Barnhart S; Shen X; Vivekanandan-Giri A; Wall VZ; Kowitz J; Devaraj S; O'Brien KD; Pennathur S; Tang J; Miyaoka RS; Raines EW; Bornfeldt KE. 2014. Testing the role of myeloid cell glucose flux in inflammation and atherosclerosis. Cell Rep 7(2):356-65. [PubMed: 24726364]  [MGI Ref ID J:211813]

Nofer JR; Bot M; Brodde M; Taylor PJ; Salm P; Brinkmann V; van Berkel T; Assmann G; Biessen EA. 2007. FTY720, a synthetic sphingosine 1 phosphate analogue, inhibits development of atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation 115(4):501-8. [PubMed: 17242282]  [MGI Ref ID J:130151]

Nookaew I; Gabrielsson BG; Holmang A; Sandberg AS; Nielsen J. 2010. Identifying molecular effects of diet through systems biology: influence of herring diet on sterol metabolism and protein turnover in mice. PLoS One 5(8):. [PubMed: 20808764]  [MGI Ref ID J:164017]

Nuotio-Antar AM; Hachey DL; Hasty AH. 2007. Carbenoxolone treatment attenuates symptoms of metabolic syndrome and atherogenesis in obese, hyperlipidemic mice. Am J Physiol Endocrinol Metab 293(6):E1517-28. [PubMed: 17878220]  [MGI Ref ID J:145108]

O'Brien KD; McDonald TO; Kunjathoor V; Eng K; Knopp EA; Lewis K; Lopez R; Kirk EA; Chait A; Wight TN; deBeer FC; LeBoeuf RC. 2005. Serum amyloid A and lipoprotein retention in murine models of atherosclerosis. Arterioscler Thromb Vasc Biol 25(4):785-90. [PubMed: 15692094]  [MGI Ref ID J:110024]

Okamoto R; Gery S; Gombart AF; Wang X; Castellani LW; Akagi T; Chen S; Arditi M; Ho Q; Lusis AJ; Li Q; Koeffler HP. 2014. Deficiency of CCAAT/enhancer binding protein-epsilon reduces atherosclerotic lesions in LDLR-/- mice. PLoS One 9(1):e85341. [PubMed: 24489659]  [MGI Ref ID J:211106]

Okayasu M; Nakayachi M; Hayashida C; Ito J; Kaneda T; Masuhara M; Suda N; Sato T; Hakeda Y. 2012. Low-density lipoprotein receptor deficiency causes impaired osteoclastogenesis and increased bone mass in mice because of defect in osteoclastic cell-cell fusion. J Biol Chem 287(23):19229-41. [PubMed: 22500026]  [MGI Ref ID J:186208]

Okazaki H; Tazoe F; Okazaki S; Isoo N; Tsukamoto K; Sekiya M; Yahagi N; Iizuka Y; Ohashi K; Kitamine T; Tozawa R; Inaba T; Yagyu H; Okazaki M; Shimano H; Shibata N; Arai H; Nagai RZ; Kadowaki T; Osuga J; Ishibashi S. 2006. Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver. J Lipid Res 47(9):1950-8. [PubMed: 16741291]  [MGI Ref ID J:114485]

Oliveira HC; Cosso RG; Alberici LC; Maciel EN; Salerno AG; Dorighello GG; Velho JA; de Faria EC; Vercesi AE. 2005. Oxidative stress in atherosclerosis-prone mouse is due to low antioxidant capacity of mitochondria. FASEB J 19(2):278-80. [PubMed: 15569776]  [MGI Ref ID J:105088]

Orozco LD; Kapturczak MH; Barajas B; Wang X; Weinstein MM; Wong J; Deshane J; Bolisetty S; Shaposhnik Z; Shih DM; Agarwal A; Lusis AJ; Araujo JA. 2007. Heme oxygenase-1 expression in macrophages plays a beneficial role in atherosclerosis. Circ Res 100(12):1703-11. [PubMed: 17495224]  [MGI Ref ID J:137771]

Osono Y; Woollett LA; Herz J; Dietschy JM. 1995. Role of the low density lipoprotein receptor in the flux of cholesterol through the plasma and across the tissues of the mouse. J Clin Invest 95(3):1124-32. [PubMed: 7883961]  [MGI Ref ID J:23579]

Osuga J; Yonemoto M; Yamada N; Shimano H; Yagyu H; Ohashi K; Harada K; Kamei T; Yazaki Y; Ishibashi S. 1998. Cholesterol lowering in low density lipoprotein receptor knockout mice overexpressing apolipoprotein E. J Clin Invest 102(2):386-94. [PubMed: 9664080]  [MGI Ref ID J:115142]

Ou ZJ; Li L; Liao XL; Wang YM; Hu XX; Zhang QL; Wang ZP; Yu H; Zhang X; Hu P; Xu YQ; Liang QL; Ou JS; Luo G. 2012. Apolipoprotein A-I mimetic peptide inhibits atherosclerosis by altering plasma metabolites in hypercholesterolemia. Am J Physiol Endocrinol Metab 303(6):E683-94. [PubMed: 22535745]  [MGI Ref ID J:189438]

Out R; Hoekstra M; Habets K; Meurs I; de Waard V; Hildebrand RB; Wang Y; Chimini G; Kuiper J; Van Berkel TJ; Van Eck M. 2008. Combined deletion of macrophage ABCA1 and ABCG1 leads to massive lipid accumulation in tissue macrophages and distinct atherosclerosis at relatively low plasma cholesterol levels. Arterioscler Thromb Vasc Biol 28(2):258-64. [PubMed: 18006857]  [MGI Ref ID J:147678]

Out R; Hoekstra M; Hildebrand RB; Kruit JK; Meurs I; Li Z; Kuipers F; Van Berkel TJ; Van Eck M. 2006. Macrophage ABCG1 deletion disrupts lipid homeostasis in alveolar macrophages and moderately influences atherosclerotic lesion development in LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol 26(10):2295-300. [PubMed: 16857950]  [MGI Ref ID J:128052]

Overton CD; Yancey PG; Major AS; Linton MF; Fazio S. 2007. Deletion of macrophage LDL receptor-related protein increases atherogenesis in the mouse. Circ Res 100(5):670-7. [PubMed: 17303763]  [MGI Ref ID J:133698]

Owens AP 3rd; Passam FH; Antoniak S; Marshall SM; McDaniel AL; Rudel L; Williams JC; Hubbard BK; Dutton JA; Wang J; Tobias PS; Curtiss LK; Daugherty A; Kirchhofer D; Luyendyk JP; Moriarty PM; Nagarajan S; Furie BC; Furie B; Johns DG; Temel RE; Mackman N. 2012. Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin. J Clin Invest 122(2):558-68. [PubMed: 22214850]  [MGI Ref ID J:184381]

Owens AP 3rd; Rateri DL; Howatt DA; Moore KJ; Tobias PS; Curtiss LK; Lu H; Cassis LA; Daugherty A. 2011. MyD88 deficiency attenuates angiotensin II-induced abdominal aortic aneurysm formation independent of signaling through Toll-like receptors 2 and 4. Arterioscler Thromb Vasc Biol 31(12):2813-9. [PubMed: 21960563]  [MGI Ref ID J:191452]

Paim BA; Velho JA; Castilho RF; Oliveira HC; Vercesi AE. 2008. Oxidative stress in hypercholesterolemic LDL (low-density lipoprotein) receptor knockout mice is associated with low content of mitochondrial NADP-linked substrates and is partially reversed by citrate replacement. Free Radic Biol Med 44(3):444-51. [PubMed: 17991444]  [MGI Ref ID J:130348]

Pan JH; Sukhova GK; Yang JT; Wang B; Xie T; Fu H; Zhang Y; Satoskar AR; David JR; Metz CN; Bucala R; Fang K; Simon DI; Chapman HA; Libby P; Shi GP. 2004. Macrophage migration inhibitory factor deficiency impairs atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation 109(25):3149-53. [PubMed: 15197138]  [MGI Ref ID J:102201]

Pan X; Jiang XC; Hussain MM. 2013. Impaired cholesterol metabolism and enhanced atherosclerosis in clock mutant mice. Circulation 128(16):1758-69. [PubMed: 24014832]  [MGI Ref ID J:218726]

Parathath S; Grauer L; Huang LS; Sanson M; Distel E; Goldberg IJ; Fisher EA. 2011. Diabetes adversely affects macrophages during atherosclerotic plaque regression in mice. Diabetes 60(6):1759-69. [PubMed: 21562077]  [MGI Ref ID J:177946]

Park SH; Sui Y; Gizard F; Xu J; Rios-Pilier J; Helsley RN; Han SS; Zhou C. 2012. Myeloid-specific IkappaB kinase beta deficiency decreases atherosclerosis in low-density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol 32(12):2869-76. [PubMed: 23023371]  [MGI Ref ID J:207877]

Parks BW; Gambill GP; Lusis AJ; Kabarowski JH. 2005. Loss of G2A promotes macrophage accumulation in atherosclerotic lesions of low density lipoprotein receptor-deficient mice. J Lipid Res 46(7):1405-15. [PubMed: 15834123]  [MGI Ref ID J:100498]

Parks BW; Lusis AJ; Kabarowski JH. 2006. Loss of the lysophosphatidylcholine effector, G2A, ameliorates aortic atherosclerosis in low-density lipoprotein receptor knockout mice. Arterioscler Thromb Vasc Biol 26(12):2703-9. [PubMed: 16990555]  [MGI Ref ID J:128044]

Parks BW; Srivastava R; Yu S; Kabarowski JH. 2009. ApoE-dependent modulation of HDL and atherosclerosis by G2A in LDL receptor-deficient mice independent of bone marrow-derived cells. Arterioscler Thromb Vasc Biol 29(4):539-47. [PubMed: 19164809]  [MGI Ref ID J:159778]

Paulson KE; Zhu SN; Chen M; Nurmohamed S; Jongstra-Bilen J; Cybulsky MI. 2010. Resident intimal dendritic cells accumulate lipid and contribute to the initiation of atherosclerosis. Circ Res 106(2):383-90. [PubMed: 19893012]  [MGI Ref ID J:170071]

Persson L; Boren J; Nicoletti A; Hansson GK; Pekna M. 2005. Immunoglobulin treatment reduces atherosclerosis in apolipoprotein E-/- low-density lipoprotein receptor-/- mice via the complement system. Clin Exp Immunol 142(3):441-5. [PubMed: 16297155]  [MGI Ref ID J:107602]

Persson L; Boren J; Robertson AK; Wallenius V; Hansson GK; Pekna M. 2004. Lack of complement factor C3, but not factor B, increases hyperlipidemia and atherosclerosis in apolipoprotein E-/- low-density lipoprotein receptor-/- mice. Arterioscler Thromb Vasc Biol 24(6):1062-7. [PubMed: 15059809]  [MGI Ref ID J:102339]

Picataggi A; Lim GF; Kent AP; Millar JS; Rader DJ; Stylianou IM. 2013. A coding variant in SR-BI (I179N) significantly increases atherosclerosis in mice. Mamm Genome :. [PubMed: 23722970]  [MGI Ref ID J:199101]

Pinkaew D; Hutadilok-Towatana N; Teng BB; Mahabusarakam W; Fujise K. 2012. Morelloflavone, a biflavonoid inhibitor of migration-related kinases, ameliorates atherosclerosis in mice. Am J Physiol Heart Circ Physiol 302(2):H451-8. [PubMed: 22058152]  [MGI Ref ID J:181657]

Pinkaew D; Le RJ; Chen Y; Eltorky M; Teng BB; Fujise K. 2013. Fortilin reduces apoptosis in macrophages and promotes atherosclerosis. Am J Physiol Heart Circ Physiol 305(10):H1519-29. [PubMed: 24043250]  [MGI Ref ID J:204609]

Plat J; Beugels I; Gijbels MJ; de Winther MP; Mensink RP. 2006. Plant sterol or stanol esters retard lesion formation in LDL receptor-deficient mice independent of changes in serum plant sterols. J Lipid Res 47(12):2762-71. [PubMed: 16957178]  [MGI Ref ID J:117204]

Plump AS; Masucci-Magoulas L; Bruce C; Bisgaier CL; Breslow JL; Tall AR. 1999. Increased atherosclerosis in ApoE and LDL receptor gene knock-out mice as a result of human cholesteryl ester transfer protein transgene expression. Arterioscler Thromb Vasc Biol 19(4):1105-10. [PubMed: 10195942]  [MGI Ref ID J:55980]

Podrez EA; Byzova TV; Febbraio M; Salomon RG; Ma Y; Valiyaveettil M; Poliakov E; Sun M; Finton PJ; Curtis BR; Chen J; Zhang R; Silverstein RL; Hazen SL. 2007. Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype. Nat Med 13(9):1086-95. [PubMed: 17721545]  [MGI Ref ID J:125153]

Poduri A; Owens AP 3rd; Howatt DA; Moorleghen JJ; Balakrishnan A; Cassis LA; Daugherty A. 2012. Regional variation in aortic AT1b receptor mRNA abundance is associated with contractility but unrelated to atherosclerosis and aortic aneurysms. PLoS One 7(10):e48462. [PubMed: 23119030]  [MGI Ref ID J:192277]

Pols TW; Nomura M; Harach T; Lo Sasso G; Oosterveer MH; Thomas C; Rizzo G; Gioiello A; Adorini L; Pellicciari R; Auwerx J; Schoonjans K. 2011. TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading. Cell Metab 14(6):747-57. [PubMed: 22152303]  [MGI Ref ID J:179660]

Postea O; Vasina EM; Cauwenberghs S; Projahn D; Liehn EA; Lievens D; Theelen W; Kramp BK; Butoi ED; Soehnlein O; Heemskerk JW; Ludwig A; Weber C; Koenen RR. 2012. Contribution of platelet CX(3)CR1 to platelet-monocyte complex formation and vascular recruitment during hyperlipidemia. Arterioscler Thromb Vasc Biol 32(5):1186-93. [PubMed: 22383701]  [MGI Ref ID J:196930]

Potteaux S; Esposito B; van Oostrom O; Brun V; Ardouin P; Groux H; Tedgui A; Mallat Z. 2004. Leukocyte-derived interleukin 10 is required for protection against atherosclerosis in low-density lipoprotein receptor knockout mice. Arterioscler Thromb Vasc Biol 24(8):1474-8. [PubMed: 15178562]  [MGI Ref ID J:102225]

Poupel L; Boissonnas A; Hermand P; Dorgham K; Guyon E; Auvynet C; Charles FS; Lesnik P; Deterre P; Combadiere C. 2013. Pharmacological inhibition of the chemokine receptor, CX3CR1, reduces atherosclerosis in mice. Arterioscler Thromb Vasc Biol 33(10):2297-305. [PubMed: 23887641]  [MGI Ref ID J:222227]

Powell-Braxton L; Veniant M; Latvala RD; Hirano KI; Won WB; Ross J; Dybdal N; Zlot CH; Young SG; Davidson NO. 1998. A mouse model of human familial hypercholesterolemia: markedly elevated low density lipoprotein cholesterol levels and severe atherosclerosis on a low-fat chow diet [see comments] Nat Med 4(8):934-8. [PubMed: 9701246]  [MGI Ref ID J:49125]

Pratico D; Cyrus T; Li H; FitzGerald GA. 2000. Endogenous biosynthesis of thromboxane and prostacyclin in 2 distinct murine models of atherosclerosis Blood 96(12):3823-6. [PubMed: 11090066]  [MGI Ref ID J:66258]

Pratico D; Rokach J; Tangirala RK. 1999. Brains of aged apolipoprotein E-deficient mice have increased levels of F2-isoprostanes, in vivo markers of lipid peroxidation. J Neurochem 73(2):736-41. [PubMed: 10428071]  [MGI Ref ID J:111985]

Pratico D; Tillmann C; Zhang ZB; Li H; FitzGerald GA. 2001. Acceleration of atherogenesis by COX-1-dependent prostanoid formation in low density lipoprotein receptor knockout mice. Proc Natl Acad Sci U S A 98(6):3358-63. [PubMed: 11248083]  [MGI Ref ID J:68091]

Preusch MR; Rattazzi M; Albrecht C; Merle U; Tuckermann J; Schutz G; Blessing E; Zoppellaro G; Pauletto P; Krempien R; Rosenfeld ME; Katus HA; Bea F. 2008. Critical role of macrophages in glucocorticoid driven vascular calcification in a mouse-model of atherosclerosis. Arterioscler Thromb Vasc Biol 28(12):2158-64. [PubMed: 18787189]  [MGI Ref ID J:159796]

Qian YW; Schmidt RJ; Zhang Y; Chu S; Lin A; Wang H; Wang X; Beyer TP; Bensch WR; Li W; Ehsani ME; Lu D; Konrad RJ; Eacho PI; Moller DE; Karathanasis SK; Cao G. 2007. Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis. J Lipid Res 48(7):1488-98. [PubMed: 17449864]  [MGI Ref ID J:122491]

Qiang L; Lin HV; Kim-Muller JY; Welch CL; Gu W; Accili D. 2011. Proatherogenic abnormalities of lipid metabolism in SirT1 transgenic mice are mediated through Creb deacetylation. Cell Metab 14(6):758-67. [PubMed: 22078933]  [MGI Ref ID J:179674]

Qiang L; Tsuchiya K; Kim-Muller JY; Lin HV; Welch C; Accili D. 2012. Increased atherosclerosis and endothelial dysfunction in mice bearing constitutively deacetylated alleles of Foxo1 gene. J Biol Chem 287(17):13944-51. [PubMed: 22389493]  [MGI Ref ID J:184477]

Qiu H; Gabrielsen A; Agardh HE; Wan M; Wetterholm A; Wong CH; Hedin U; Swedenborg J; Hansson GK; Samuelsson B; Paulsson-Berne G; Haeggstrom JZ. 2006. Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability. Proc Natl Acad Sci U S A 103(21):8161-6. [PubMed: 16698924]  [MGI Ref ID J:110208]

Qu A; Shah YM; Manna SK; Gonzalez FJ. 2012. Disruption of endothelial peroxisome proliferator-activated receptor gamma accelerates diet-induced atherogenesis in LDL receptor-null mice. Arterioscler Thromb Vasc Biol 32(1):65-73. [PubMed: 22015658]  [MGI Ref ID J:195979]

Quan G; Xie C; Dietschy JM; Turley SD. 2003. Ontogenesis and regulation of cholesterol metabolism in the central nervous system of the mouse. Brain Res Dev Brain Res 146(1-2):87-98. [PubMed: 14643015]  [MGI Ref ID J:86935]

Radonjic M; Wielinga PY; Wopereis S; Kelder T; Goelela VS; Verschuren L; Toet K; van Duyvenvoorde W; van der Werff van der Vat B; Stroeve JH; Cnubben N; Kooistra T; van Ommen B; Kleemann R. 2013. Differential effects of drug interventions and dietary lifestyle in developing type 2 diabetes and complications: a systems biology analysis in LDLr-/- mice. PLoS One 8(2):e56122. [PubMed: 23457508]  [MGI Ref ID J:198285]

Raikwar NS; Cho WK; Bowen RF; Deeg MA. 2006. Glycosylphosphatidylinositol-specific phospholipase D influences triglyceride-rich lipoprotein metabolism. Am J Physiol Endocrinol Metab 290(3):E463-70. [PubMed: 16219662]  [MGI Ref ID J:106052]

Ramirez C; Sierra S; Tercero I; Vazquez JA; Pineda A; Manrique T; Burgos JS. 2011. ApoB100/LDLR-/- hypercholesterolaemic mice as a model for mild cognitive impairment and neuronal damage. PLoS One 6(7):e22712. [PubMed: 21829488]  [MGI Ref ID J:175834]

Ramsey SA; Vengrenyuk Y; Menon P; Podolsky I; Feig JE; Aderem A; Fisher EA; Gold ES. 2014. Epigenome-guided analysis of the transcriptome of plaque macrophages during atherosclerosis regression reveals activation of the Wnt signaling pathway. PLoS Genet 10(12):e1004828. [PubMed: 25474352]  [MGI Ref ID J:222183]

Rashid S; Curtis DE; Garuti R; Anderson NN; Bashmakov Y; Ho YK; Hammer RE; Moon YA; Horton JD. 2005. Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9. Proc Natl Acad Sci U S A 102(15):5374-9. [PubMed: 15805190]  [MGI Ref ID J:97836]

Rateri DL; Davis FM; Balakrishnan A; Howatt DA; Moorleghen JJ; O'Connor WN; Charnigo R; Cassis LA; Daugherty A. 2014. Angiotensin II induces region-specific medial disruption during evolution of ascending aortic aneurysms. Am J Pathol 184(9):2586-95. [PubMed: 25038458]  [MGI Ref ID J:213954]

Rateri DL; Moorleghen JJ; Balakrishnan A; Owens AP 3rd; Howatt DA; Subramanian V; Poduri A; Charnigo R; Cassis LA; Daugherty A. 2011. Endothelial Cell-Specific Deficiency of Ang II Type 1a Receptors Attenuates Ang II-Induced Ascending Aortic Aneurysms in LDL Receptor-/- Mice. Circ Res 108(5):574-81. [PubMed: 21252156]  [MGI Ref ID J:170230]

Rateri DL; Moorleghen JJ; Knight V; Balakrishnan A; Howatt DA; Cassis LA; Daugherty A. 2012. Depletion of endothelial or smooth muscle cell-specific angiotensin II type 1a receptors does not influence aortic aneurysms or atherosclerosis in LDL receptor deficient mice. PLoS One 7(12):e51483. [PubMed: 23236507]  [MGI Ref ID J:195549]

Ratliff EP; Gutierrez A; Davis RA. 2006. Transgenic expression of CYP7A1 in LDL receptor-deficient mice blocks diet-induced hypercholesterolemia. J Lipid Res 47(7):1513-20. [PubMed: 16609145]  [MGI Ref ID J:112052]

Rayner KJ; Suarez Y; Davalos A; Parathath S; Fitzgerald ML; Tamehiro N; Fisher EA; Moore KJ; Fernandez-Hernando C. 2010. MiR-33 contributes to the regulation of cholesterol homeostasis. Science 328(5985):1570-3. [PubMed: 20466885]  [MGI Ref ID J:160971]

Recinos A rd; Carr BK; Bartos DB; Boldogh I; Carmical JR; Belalcazar LM; Brasier AR. 2004. Liver gene expression associated with diet and lesion development in atherosclerosis-prone mice: induction of components of alternative complement pathway. Physiol Genomics 19(1):131-42. [PubMed: 15238619]  [MGI Ref ID J:106239]

Reddy ST; Nguyen JT; Grijalva V; Hough G; Hama S; Navab M; Fogelman AM. 2004. Potential role for mitogen-activated protein kinase phosphatase-1 in the development of atherosclerotic lesions in mouse models. Arterioscler Thromb Vasc Biol 24(9):1676-81. [PubMed: 15242861]  [MGI Ref ID J:102220]

Reiterer G; MacDonald R; Browning JD; Morrow J; Matveev SV; Daugherty A; Smart E; Toborek M; Hennig B. 2005. Zinc deficiency increases plasma lipids and atherosclerotic markers in LDL-receptor-deficient mice. J Nutr 135(9):2114-8. [PubMed: 16140885]  [MGI Ref ID J:106652]

Renard CB; Kramer F; Johansson F; Lamharzi N; Tannock LR; von Herrath MG; Chait A; Bornfeldt KE. 2004. Diabetes and diabetes-associated lipid abnormalities have distinct effects on initiation and progression of atherosclerotic lesions. J Clin Invest 114(5):659-68. [PubMed: 15343384]  [MGI Ref ID J:92597]

Rensen SS; Bieghs V; Xanthoulea S; Arfianti E; Bakker JA; Shiri-Sverdlov R; Hofker MH; Greve JW; Buurman WA. 2012. Neutrophil-derived myeloperoxidase aggravates non-alcoholic steatohepatitis in low-density lipoprotein receptor-deficient mice. PLoS One 7(12):e52411. [PubMed: 23285030]  [MGI Ref ID J:195762]

Rensing KL; de Jager SC; Stroes ES; Vos M; Twickler MT; Dallinga-Thie GM; de Vries CJ; Kuiper J; Bot I; von der Thusen JH. 2014. Akt2/LDLr double knockout mice display impaired glucose tolerance and develop more complex atherosclerotic plaques than LDLr knockout mice. Cardiovasc Res 101(2):277-87. [PubMed: 24220638]  [MGI Ref ID J:219538]

Repa JJ; Li H; Frank-Cannon TC; Valasek MA; Turley SD; Tansey MG; Dietschy JM. 2007. Liver X receptor activation enhances cholesterol loss from the brain, decreases neuroinflammation, and increases survival of the NPC1 mouse. J Neurosci 27(52):14470-80. [PubMed: 18160655]  [MGI Ref ID J:130969]

Repa JJ; Turley SD; Quan G; Dietschy JM. 2005. Delineation of molecular changes in intrahepatic cholesterol metabolism resulting from diminished cholesterol absorption. J Lipid Res 46(4):779-89. [PubMed: 15654122]  [MGI Ref ID J:98574]

Rinninger F; Heine M; Singaraja R; Hayden M; Brundert M; Ramakrishnan R; Heeren J. 2014. High density lipoprotein metabolism in low density lipoprotein receptor-deficient mice. J Lipid Res 55(9):1914-24. [PubMed: 24954421]  [MGI Ref ID J:214973]

Robbins CS; Chudnovskiy A; Rauch PJ; Figueiredo JL; Iwamoto Y; Gorbatov R; Etzrodt M; Weber GF; Ueno T; van Rooijen N; Mulligan-Kehoe MJ; Libby P; Nahrendorf M; Pittet MJ; Weissleder R; Swirski FK. 2012. Extramedullary hematopoiesis generates Ly-6C(high) monocytes that infiltrate atherosclerotic lesions. Circulation 125(2):364-74. [PubMed: 22144566]  [MGI Ref ID J:193795]

Robbins CS; Hilgendorf I; Weber GF; Theurl I; Iwamoto Y; Figueiredo JL; Gorbatov R; Sukhova GK; Gerhardt LM; Smyth D; Zavitz CC; Shikatani EA; Parsons M; van Rooijen N; Lin HY; Husain M; Libby P; Nahrendorf M; Weissleder R; Swirski FK. 2013. Local proliferation dominates lesional macrophage accumulation in atherosclerosis. Nat Med 19(9):1166-72. [PubMed: 23933982]  [MGI Ref ID J:201890]

Rogers L; Burchat S; Gage J; Hasu M; Thabet M; Wilcox L; Ramsamy TA; Whitman SC. 2008. Deficiency of invariant V alpha 14 natural killer T cells decreases atherosclerosis in LDL receptor null mice. Cardiovasc Res 78(1):167-74. [PubMed: 18192239]  [MGI Ref ID J:140276]

Rohlmann A; Gotthardt M; Hammer RE; Herz J. 1998. Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants. J Clin Invest 101(3):689-95. [PubMed: 9449704]  [MGI Ref ID J:67929]

Romeo GR; Moulton KS; Kazlauskas A. 2007. Attenuated expression of profilin-1 confers protection from atherosclerosis in the LDL receptor null mouse. Circ Res 101(4):357-67. [PubMed: 17615372]  [MGI Ref ID J:140294]

Rong S; Cao Q; Liu M; Seo J; Jia L; Boudyguina E; Gebre AK; Colvin PL; Smith TL; Murphy RC; Mishra N; Parks JS. 2012. Macrophage 12/15 lipoxygenase expression increases plasma and hepatic lipid levels and exacerbates atherosclerosis. J Lipid Res 53(4):686-95. [PubMed: 22279185]  [MGI Ref ID J:184947]

Roselaar SE; Kakkanathu PX; Daugherty A. 1996. Lymphocyte populations in atherosclerotic lesions of apoE -/- and LDL receptor -/- mice. Decreasing density with disease progression. Arterioscler Thromb Vasc Biol 16(8):1013-8. [PubMed: 8696940]  [MGI Ref ID J:111962]

Rotllan N; Chamorro-Jorganes A; Araldi E; Wanschel AC; Aryal B; Aranda JF; Goedeke L; Salerno AG; Ramirez CM; Sessa WC; Suarez Y; Fernandez-Hernando C. 2015. Hematopoietic Akt2 deficiency attenuates the progression of atherosclerosis. FASEB J 29(2):597-610. [PubMed: 25392271]  [MGI Ref ID J:218205]

Roubtsova A; Munkonda MN; Awan Z; Marcinkiewicz J; Chamberland A; Lazure C; Cianflone K; Seidah NG; Prat A. 2011. Circulating proprotein convertase subtilisin/kexin 9 (PCSK9) regulates VLDLR protein and triglyceride accumulation in visceral adipose tissue. Arterioscler Thromb Vasc Biol 31(4):785-91. [PubMed: 21273557]  [MGI Ref ID J:184166]

Rousselet E; Marcinkiewicz J; Kriz J; Zhou A; Hatten ME; Prat A; Seidah NG. 2011. PCSK9 reduces the protein levels of the LDL receptor in mouse brain during development and after ischemic stroke. J Lipid Res 52(7):1383-91. [PubMed: 21518694]  [MGI Ref ID J:174826]

Rudling M; Angelin B. 2001. Growth hormone reduces plasma cholesterol in LDL receptor-deficient mice. FASEB J 15(8):1350-6. [PubMed: 11387232]  [MGI Ref ID J:120519]

Rudolf M; Winkler B; Aherrahou Z; Doehring LC; Kaczmarek P; Schmidt-Erfurth U. 2005. Increased expression of vascular endothelial growth factor associated with accumulation of lipids in Bruch's membrane of LDL receptor knockout mice. Br J Ophthalmol 89(12):1627-30. [PubMed: 16299144]  [MGI Ref ID J:116908]

Ruotsalainen AK; Inkala M; Partanen ME; Lappalainen JP; Kansanen E; Makinen PI; Heinonen SE; Laitinen HM; Heikkila J; Vatanen T; Horkko S; Yamamoto M; Yla-Herttuala S; Jauhiainen M; Levonen AL. 2013. The absence of macrophage Nrf2 promotes early atherogenesis. Cardiovasc Res 98(1):107-15. [PubMed: 23341579]  [MGI Ref ID J:210429]

Sag D; Cekic C; Wu R; Linden J; Hedrick CC. 2015. The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity. Nat Commun 6:6354. [PubMed: 25724068]  [MGI Ref ID J:221785]

Saito R; Matsuzaka T; Karasawa T; Sekiya M; Okada N; Igarashi M; Matsumori R; Ishii K; Nakagawa Y; Iwasaki H; Kobayashi K; Yatoh S; Takahashi A; Sone H; Suzuki H; Yahagi N; Yamada N; Shimano H. 2011. Macrophage Elovl6 deficiency ameliorates foam cell formation and reduces atherosclerosis in low-density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol 31(9):1973-9. [PubMed: 21817094]  [MGI Ref ID J:191842]

Sakai K; Tiebel O; Ljungberg MC; Sullivan M; Lee HJ; Terashima T; Li R; Kobayashi K; Lu HC; Chan L; Oka K. 2009. A neuronal VLDLR variant lacking the third complement-type repeat exhibits high capacity binding of apoE containing lipoproteins. Brain Res 1276:11-21. [PubMed: 19393635]  [MGI Ref ID J:157221]

Sakamoto N; Rosenberg AS. 2011. Apolipoprotein B binding domains: evidence that they are cell-penetrating peptides that efficiently deliver antigenic peptide for cross-presentation of cytotoxic T cells. J Immunol 186(8):5004-11. [PubMed: 21402897]  [MGI Ref ID J:172521]

Samyn H; Moerland M; van Gent T; van Haperen R; Metso J; Grosveld F; Jauhiainen M; van Tol A; de Crom R. 2008. Plasma phospholipid transfer activity is essential for increased atherogenesis in PLTP transgenic mice: a mutation-inactivation study. J Lipid Res 49(12):2504-12. [PubMed: 18711210]  [MGI Ref ID J:142969]

Sanan DA; Newland DL; Tao R; Marcovina S; Wang J; Mooser V; Hammer RE; Hobbs HH. 1998. Low density lipoprotein receptor-negative mice expressing human apolipoprotein B-100 develop complex atherosclerotic lesions on a chow diet: no accentuation by apolipoprotein(a). Proc Natl Acad Sci U S A 95(8):4544-9. [PubMed: 9539774]  [MGI Ref ID J:47464]

Saraswathi V; Morrow JD; Hasty AH. 2009. Dietary fish oil exerts hypolipidemic effects in lean and insulin sensitizing effects in obese LDLR-/- mice. J Nutr 139(12):2380-6. [PubMed: 19864403]  [MGI Ref ID J:154774]

Schiller NK; Black AS; Bradshaw GP; Bonnet DJ; Curtiss LK. 2004. Participation of macrophages in atherosclerotic lesion morphology in LDLr-/- mice. J Lipid Res 45(8):1398-409. [PubMed: 15175354]  [MGI Ref ID J:91367]

Schiller NK; Boisvert WA; Curtiss LK. 2002. Inflammation in atherosclerosis: lesion formation in LDL receptor-deficient mice with perforin and Lyst(beige) mutations. Arterioscler Thromb Vasc Biol 22(8):1341-6. [PubMed: 12171798]  [MGI Ref ID J:103214]

Schmidt-Erfurth U; Rudolf M; Funk M; Hofmann-Rummelt C; Franz-Haas NS; Aherrahrou Z; Schlotzer-Schrehardt U. 2008. Ultrastructural changes in a murine model of graded Bruch membrane lipoidal degeneration and corresponding VEGF164 detection. Invest Ophthalmol Vis Sci 49(1):390-8. [PubMed: 18172117]  [MGI Ref ID J:132498]

Schneider F; Sukhova GK; Aikawa M; Canner J; Gerdes N; Tang SM; Shi GP; Apte SS; Libby P. 2008. Matrix-metalloproteinase-14 deficiency in bone-marrow-derived cells promotes collagen accumulation in mouse atherosclerotic plaques. Circulation 117(7):931-9. [PubMed: 18250269]  [MGI Ref ID J:145079]

Schneider JG; Finck BN; Ren J; Standley KN; Takagi M; Maclean KH; Bernal-Mizrachi C; Muslin AJ; Kastan MB; Semenkovich CF. 2006. ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome. Cell Metab 4(5):377-89. [PubMed: 17084711]  [MGI Ref ID J:129761]

Schonbeck U; Sukhova GK; Shimizu K; Mach F; Libby P. 2000. Inhibition of CD40 signaling limits evolution of established atherosclerosis in mice [see comments] Proc Natl Acad Sci U S A 97(13):7458-63. [PubMed: 10861012]  [MGI Ref ID J:63076]

Schreyer SA; Vick C; Lystig TC; Mystkowski P; LeBoeuf RC. 2002. LDL receptor but not apolipoprotein E deficiency increases diet-induced obesity and diabetes in mice. Am J Physiol Endocrinol Metab 282(1):E207-14. [PubMed: 11739102]  [MGI Ref ID J:75609]

Schroeter MR; Leifheit-Nestler M; Hubert A; Schumann B; Gluckermann R; Eschholz N; Kruger N; Lutz S; Hasenfuss G; Konstantinides S; Schafer K. 2013. Leptin promotes neointima formation and smooth muscle cell proliferation via NADPH oxidase activation and signalling in caveolin-rich microdomains. Cardiovasc Res 99(3):555-65. [PubMed: 23723060]  [MGI Ref ID J:218655]

Sehayek E; Ono JG; Duncan EM; Batta AK; Salen G; Shefer S; Neguyen LB; Yang K; Lipkin M; Breslow JL. 2001. Hyodeoxycholic acid efficiently suppresses atherosclerosis formation and plasma cholesterol levels in mice. J Lipid Res 42(8):1250-6. [PubMed: 11483626]  [MGI Ref ID J:70721]

Seidelmann SB; Kuo C; Pleskac N; Molina J; Sayers S; Li R; Zhou J; Johnson P; Braun K; Chan C; Teupser D; Breslow JL; Wight TN; Tall AR; Welch CL. 2008. Athsq1 is an atherosclerosis modifier locus with dramatic effects on lesion area and prominent accumulation of versican. Arterioscler Thromb Vasc Biol 28(12):2180-6. [PubMed: 18818413]  [MGI Ref ID J:159792]

Seimon TA; Nadolski MJ; Liao X; Magallon J; Nguyen M; Feric NT; Koschinsky ML; Harkewicz R; Witztum JL; Tsimikas S; Golenbock D; Moore KJ; Tabas I. 2010. Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress. Cell Metab 12(5):467-82. [PubMed: 21035758]  [MGI Ref ID J:167910]

Sekiya M; Osuga J; Nagashima S; Ohshiro T; Igarashi M; Okazaki H; Takahashi M; Tazoe F; Wada T; Ohta K; Takanashi M; Kumagai M; Nishi M; Takase S; Yahagi N; Yagyu H; Ohashi K; Nagai R; Kadowaki T; Furukawa Y; Ishibashi S. 2009. Ablation of neutral cholesterol ester hydrolase 1 accelerates atherosclerosis. Cell Metab 10(3):219-28. [PubMed: 19723498]  [MGI Ref ID J:152385]

Semenkovich CF; Coleman T; Daugherty A. 1998. Effects of heterozygous lipoprotein lipase deficiency on diet-induced atherosclerosis in mice. J Lipid Res 39(6):1141-51. [PubMed: 9643345]  [MGI Ref ID J:48030]

Senokuchi T; Liang CP; Seimon TA; Han S; Matsumoto M; Banks AS; Paik JH; DePinho RA; Accili D; Tabas I; Tall AR. 2008. Forkhead transcription factors (FoxOs) promote apoptosis of insulin-resistant macrophages during cholesterol-induced endoplasmic reticulum stress. Diabetes 57(11):2967-76. [PubMed: 18728232]  [MGI Ref ID J:142468]

Shah Z; Kampfrath T; Deiuliis JA; Zhong J; Pineda C; Ying Z; Xu X; Lu B; Moffatt-Bruce S; Durairaj R; Sun Q; Mihai G; Maiseyeu A; Rajagopalan S. 2011. Long-term dipeptidyl-peptidase 4 inhibition reduces atherosclerosis and inflammation via effects on monocyte recruitment and chemotaxis. Circulation 124(21):2338-49. [PubMed: 22007077]  [MGI Ref ID J:189450]

Shao JS; Sierra OL; Cohen R; Mecham RP; Kovacs A; Wang J; Distelhorst K; Behrmann A; Halstead LR; Towler DA. 2011. Vascular calcification and aortic fibrosis: a bifunctional role for osteopontin in diabetic arteriosclerosis. Arterioscler Thromb Vasc Biol 31(8):1821-33. [PubMed: 21597007]  [MGI Ref ID J:191858]

Shaposhnik Z; Wang X; Lusis AJ. 2010. Arterial colony stimulating factor-1 influences atherosclerotic lesions by regulating monocyte migration and apoptosis. J Lipid Res 51(7):1962-70. [PubMed: 20194110]  [MGI Ref ID J:162834]

Shaposhnik Z; Wang X; Weinstein M; Bennett BJ; Lusis AJ. 2007. Granulocyte macrophage colony-stimulating factor regulates dendritic cell content of atherosclerotic lesions. Arterioscler Thromb Vasc Biol 27(3):621-7. [PubMed: 17158354]  [MGI Ref ID J:130538]

Sharabi Y; Grossman E; Sherer Y; Shaish A; Levkovitz H; Bitzur R; Harats D. 2000. The effect of renin-angiotensin axis inhibition on early atherogenesis in LDL-receptor-deficient mice. Pathobiology 68(6):270-4. [PubMed: 11493760]  [MGI Ref ID J:71167]

Sherer Y; Shoenfeld Y; Shaish A; Levkovitz H; Bitzur R; Harats D. 2000. Suppression of atherogenesis in female low-density lipoprotein receptor knockout mice following magnesium fortification of drinking water: the importance of diet. Pathobiology 68(2):93-8. [PubMed: 10878506]  [MGI Ref ID J:63520]

Shi W; Wang X; Wong J; Hedrick CC; Wong H; Castellani LW; Lusis AJ. 2004. Effect of macrophage-derived apolipoprotein E on hyperlipidemia and atherosclerosis of LDLR-deficient mice. Biochem Biophys Res Commun 317(1):223-9. [PubMed: 15047172]  [MGI Ref ID J:88891]

Shih DM; Shaposhnik Z; Meng Y; Rosales M; Wang X; Wu J; Ratiner B; Zadini F; Zadini G; Lusis AJ. 2013. Hyodeoxycholic acid improves HDL function and inhibits atherosclerotic lesion formation in LDLR-knockout mice. FASEB J 27(9):3805-17. [PubMed: 23752203]  [MGI Ref ID J:201179]

Shih DM; Xia YR; Wang XP; Wang SS; Bourquard N; Fogelman AM; Lusis AJ; Reddy ST. 2007. Decreased obesity and atherosclerosis in human paraoxonase 3 transgenic mice. Circ Res 100(8):1200-7. [PubMed: 17379834]  [MGI Ref ID J:135375]

Shimada M; Ishibashi S; Inaba T; Yagyu H; Harada K; Osuga JI; Ohashi K; Yazaki Y; Yamada N. 1996. Suppression of diet-induced atherosclerosis in low density lipoprotein receptor knockout mice overexpressing lipoprotein lipase. Proc Natl Acad Sci U S A 93(14):7242-6. [PubMed: 8692976]  [MGI Ref ID J:34082]

Sigel S; Bunk S; Meergans T; Doninger B; Stich K; Stulnig T; Derfler K; Hoffmann J; Deininger S; von Aulock S; Knapp S. 2012. Apolipoprotein B100 is a suppressor of Staphylococcus aureus-induced innate immune responses in humans and mice. Eur J Immunol 42(11):2983-9. [PubMed: 22806614]  [MGI Ref ID J:188717]

Silvola JM; Saraste A; Forsback S; Laine VJ; Saukko P; Heinonen SE; Yla-Herttuala S; Roivainen A; Knuuti J. 2011. Detection of hypoxia by [18F]EF5 in atherosclerotic plaques in mice. Arterioscler Thromb Vasc Biol 31(5):1011-5. [PubMed: 21372297]  [MGI Ref ID J:191482]

Singh I; Sagare AP; Coma M; Perlmutter D; Gelein R; Bell RD; Deane RJ; Zhong E; Parisi M; Ciszewski J; Kasper RT; Deane R. 2013. Low levels of copper disrupt brain amyloid-beta homeostasis by altering its production and clearance. Proc Natl Acad Sci U S A 110(36):14771-6. [PubMed: 23959870]  [MGI Ref ID J:200976]

Singh U; Zhong S; Xiong M; Li TB; Sniderman A; Teng BB. 2004. Increased plasma non-esterified fatty acids and platelet-activating factor acetylhydrolase are associated with susceptibility to atherosclerosis in mice. Clin Sci (Lond) 106(4):421-32. [PubMed: 14717654]  [MGI Ref ID J:105456]

Sjoland H; Eitzman DT; Gordon D; Westrick R; Nabel EG; Ginsburg D. 2000. Atherosclerosis progression in LDL receptor-deficient and apolipoprotein E-deficient mice is independent of genetic alterations in plasminogen activator inhibitor-1. Arterioscler Thromb Vasc Biol 20(3):846-52. [PubMed: 10712412]  [MGI Ref ID J:61287]

Skogsberg J; Dicker A; Ryden M; Astrom G; Nilsson R; Bhuiyan H; Vitols S; Mairal A; Langin D; Alberts P; Walum E; Tegner J; Hamsten A; Arner P; Bjorkegren J. 2008. ApoB100-LDL acts as a metabolic signal from liver to peripheral fat causing inhibition of lipolysis in adipocytes. PLoS ONE 3(11):e3771. [PubMed: 19020660]  [MGI Ref ID J:143905]

Skogsberg J; Lundstrom J; Kovacs A; Nilsson R; Noori P; Maleki S; Kohler M; Hamsten A; Tegner J; Bjorkegren J. 2008. Transcriptional profiling uncovers a network of cholesterol-responsive atherosclerosis target genes. PLoS Genet 4(3):e1000036. [PubMed: 18369455]  [MGI Ref ID J:136835]

Solca C; Pandit B; Yu H; Tint GS; Patel SB. 2007. Loss of apolipoprotein E exacerbates the neonatal lethality of the Smith-Lemli-Opitz syndrome mouse. Mol Genet Metab 91(1):7-14. [PubMed: 17197219]  [MGI Ref ID J:121454]

Sommerville LJ; Kelemen SE; Autieri MV. 2008. Increased smooth muscle cell activation and neointima formation in response to injury in AIF-1 transgenic mice. Arterioscler Thromb Vasc Biol 28(1):47-53. [PubMed: 17991871]  [MGI Ref ID J:147519]

Song H; Zhu L; Picardo CM; Maguire G; Leung V; Connelly PW; Ng DS. 2006. Coordinated alteration of hepatic gene expression in fatty acid and triglyceride synthesis in LCAT-null mice is associated with altered PUFA metabolism. Am J Physiol Endocrinol Metab 290(1):E17-E25. [PubMed: 16105858]  [MGI Ref ID J:104219]

Song L; Leung C; Schindler C. 2001. Lymphocytes are important in early atherosclerosis. J Clin Invest 108(2):251-9. [PubMed: 11457878]  [MGI Ref ID J:118405]

Sontag TJ; Chellan B; Bhanvadia CV; Getz GS; Reardon CA. 2015. Alginic acid cell entrapment: a novel method for measuring in vivo macrophage cholesterol homeostasis. J Lipid Res 56(2):470-83. [PubMed: 25465389]  [MGI Ref ID J:219836]

Sontag TJ; Chellan B; Getz GS; Reardon CA. 2013. Differing rates of cholesterol absorption among inbred mouse strains yield differing levels of HDL-cholesterol. J Lipid Res 54(9):2515-24. [PubMed: 23812556]  [MGI Ref ID J:200771]

Sorci-Thomas MG; Zabalawi M; Bharadwaj MS; Wilhelm AJ; Owen JS; Asztalos BF; Bhat S; Thomas MJ. 2012. Dysfunctional HDL containing L159R ApoA-I leads to exacerbation of atherosclerosis in hyperlipidemic mice. Biochim Biophys Acta 1821(3):502-12. [PubMed: 21944998]  [MGI Ref ID J:182370]

Souza JC; Vanzela EC; Ribeiro RA; Rezende LF; de Oliveira CA; Carneiro EM; Oliveira HC; Boschero AC. 2013. Cholesterol reduction ameliorates glucose-induced calcium handling and insulin secretion in islets from low-density lipoprotein receptor knockout mice. Biochim Biophys Acta 1831(4):769-75. [PubMed: 23298460]  [MGI Ref ID J:199048]

Spady DK; Cuthbert JA; Willard MN; Meidell RS. 1998. Overexpression of cholesterol 7alpha-hydroxylase (CYP7A) in mice lacking the low density lipoprotein (LDL) receptor gene. LDL transport and plasma LDL concentrations are reduced. J Biol Chem 273(1):126-32. [PubMed: 9417056]  [MGI Ref ID J:45043]

Spann NJ; Garmire LX; McDonald JG; Myers DS; Milne SB; Shibata N; Reichart D; Fox JN; Shaked I; Heudobler D; Raetz CR; Wang EW; Kelly SL; Sullards MC; Murphy RC; Merrill AH Jr; Brown HA; Dennis EA; Li AC; Ley K; Tsimikas S; Fahy E; Subramaniam S; Quehenberger O; Russell DW; Glass CK. 2012. Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses. Cell 151(1):138-52. [PubMed: 23021221]  [MGI Ref ID J:188262]

Stachon P; Missiou A; Walter C; Varo N; Colberg C; Wolf D; Buchner M; von Zur Muhlen C; Zirlik K; Bode C; Zirlik A. 2010. Tumor necrosis factor receptor associated factor 6 is not required for atherogenesis in mice and does not associate with atherosclerosis in humans. PLoS One 5(7):e11589. [PubMed: 20644648]  [MGI Ref ID J:163110]

Stanford KI; Bishop JR; Foley EM; Gonzales JC; Niesman IR; Witztum JL; Esko JD. 2009. Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice. J Clin Invest 119(11):3236-45. [PubMed: 19805913]  [MGI Ref ID J:154621]

Stanic AK; Stein CM; Morgan AC; Fazio S; Linton MF; Wakeland EK; Olsen NJ; Major AS. 2006. Immune dysregulation accelerates atherosclerosis and modulates plaque composition in systemic lupus erythematosus. Proc Natl Acad Sci U S A 103(18):7018-23. [PubMed: 16636270]  [MGI Ref ID J:109461]

Staprans I; Pan XM; Rapp JH; Grunfeld C; Feingold KR. 2000. Oxidized cholesterol in the diet accelerates the development of atherosclerosis in LDL receptor- and apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 20(3):708-14. [PubMed: 10712395]  [MGI Ref ID J:103278]

Steffens S; Burger F; Pelli G; Dean Y; Elson G; Kosco-Vilbois M; Chatenoud L; Mach F. 2006. Short-term treatment with anti-CD3 antibody reduces the development and progression of atherosclerosis in mice. Circulation 114(18):1977-84. [PubMed: 17043169]  [MGI Ref ID J:127202]

Stein CS; Martins I; Davidson BL. 2000. Long-term reversal of hypercholesterolemia in low density lipoprotein receptor (LDLR)-deficient mice by adenovirus-mediated LDLR gene transfer combined with CD154 blockade J Gene Med 2(1):41-51. [PubMed: 10765504]  [MGI Ref ID J:62368]

Stein S; Oosterveer MH; Mataki C; Xu P; Lemos V; Havinga R; Dittner C; Ryu D; Menzies KJ; Wang X; Perino A; Houten SM; Melchior F; Schoonjans K. 2014. SUMOylation-dependent LRH-1/PROX1 interaction promotes atherosclerosis by decreasing hepatic reverse cholesterol transport. Cell Metab 20(4):603-13. [PubMed: 25176150]  [MGI Ref ID J:215556]

Steiner T; Francescut L; Byrne S; Hughes T; Jayanthi A; Guschina I; Harwood J; Cianflone K; Stover C; Francis S. 2014. Protective role for properdin in progression of experimental murine atherosclerosis. PLoS One 9(3):e92404. [PubMed: 24667818]  [MGI Ref ID J:215053]

Strack AM; Carballo-Jane E; Wang SP; Xue J; Ping X; McNamara LA; Thankappan A; Price O; Wolff M; Wu TJ; Kawka D; Mariano M; Burton C; Chang CH; Chen J; Menke J; Luell S; Zycband EI; Tong X; Raubertas R; Sparrow CP; Hubbard B; Woods J; O'Neill G; Waters MG; Sitlani A. 2013. Nicotinic acid and DP1 blockade: studies in mouse models of atherosclerosis. J Lipid Res 54(1):177-88. [PubMed: 23103473]  [MGI Ref ID J:192168]

Strom A; Olin AI; Aspberg A; Hultgardh-Nilsson A. 2006. Fibulin-2 is present in murine vascular lesions and is important for smooth muscle cell migration. Cardiovasc Res 69(3):755-63. [PubMed: 16409997]  [MGI Ref ID J:105710]

Subbaiah PV; Jiang XC; Belikova NA; Aizezi B; Huang ZH; Reardon CA. 2012. Regulation of plasma cholesterol esterification by sphingomyelin: Effect of physiological variations of plasma sphingomyelin on lecithin-cholesterol acyltransferase activity. Biochim Biophys Acta 1821(6):908-13. [PubMed: 22370449]  [MGI Ref ID J:185003]

Subramanian M; Thorp E; Hansson GK; Tabas I. 2013. Treg-mediated suppression of atherosclerosis requires MYD88 signaling in DCs. J Clin Invest 123(1):179-88. [PubMed: 23257360]  [MGI Ref ID J:194509]

Subramanian S; Goodspeed L; Wang S; Kim J; Zeng L; Ioannou GN; Haigh WG; Yeh MM; Kowdley KV; O'Brien KD; Pennathur S; Chait A. 2011. Dietary cholesterol exacerbates hepatic steatosis and inflammation in obese LDL receptor-deficient mice. J Lipid Res 52(9):1626-35. [PubMed: 21690266]  [MGI Ref ID J:175559]

Subramanian S; Han CY; Chiba T; McMillen TS; Wang SA; Haw A rd; Kirk EA; O'Brien KD; Chait A. 2008. Dietary cholesterol worsens adipose tissue macrophage accumulation and atherosclerosis in obese LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol 28(4):685-91. [PubMed: 18239153]  [MGI Ref ID J:149038]

Subramanian V; Golledge J; Ijaz T; Bruemmer D; Daugherty A. 2010. Pioglitazone-induced reductions in atherosclerosis occur via smooth muscle cell-specific interaction with PPAR{gamma}. Circ Res 107(8):953-8. [PubMed: 20798360]  [MGI Ref ID J:178193]

Subramanian V; Moorleghen JJ; Balakrishnan A; Howatt DA; Chishti AH; Uchida HA. 2013. Calpain-2 compensation promotes angiotensin II-induced ascending and abdominal aortic aneurysms in calpain-1 deficient mice. PLoS One 8(8):e72214. [PubMed: 23977256]  [MGI Ref ID J:206427]

Sugiyama E; Tanaka N; Nakajima T; Kamijo Y; Yokoyama S; Li Y; Gonzalez FJ; Aoyama T. 2006. Haploinsufficiency in the PPARalpha and LDL receptor genes leads to gender- and age-specific obesity and hyperinsulinemia. Biochem Biophys Res Commun 350(2):370-6. [PubMed: 17011521]  [MGI Ref ID J:116049]

Sui Y; Park SH; Xu J; Monette S; Helsley RN; Han SS; Zhou C. 2014. IKKbeta links vascular inflammation to obesity and atherosclerosis. J Exp Med 211(5):869-86. [PubMed: 24799533]  [MGI Ref ID J:211281]

Sukhova GK; Zhang Y; Pan JH; Wada Y; Yamamoto T; Naito M; Kodama T; Tsimikas S; Witztum JL; Lu ML; Sakara Y; Chin MT; Libby P; Shi GP. 2003. Deficiency of cathepsin S reduces atherosclerosis in LDL receptor-deficient mice. J Clin Invest 111(6):897-906. [PubMed: 12639996]  [MGI Ref ID J:82520]

Sun H; Samarghandi A; Zhang N; Yao Z; Xiong M; Teng BB. 2012. Proprotein convertase subtilisin/kexin type 9 interacts with apolipoprotein B and prevents its intracellular degradation, irrespective of the low-density lipoprotein receptor. Arterioscler Thromb Vasc Biol 32(7):1585-95. [PubMed: 22580899]  [MGI Ref ID J:186176]

Sun J; Hartvigsen K; Chou MY; Zhang Y; Sukhova GK; Zhang J; Lopez-Ilasaca M; Diehl CJ; Yakov N; Harats D; George J; Witztum JL; Libby P; Ploegh H; Shi GP. 2010. Deficiency of antigen-presenting cell invariant chain reduces atherosclerosis in mice. Circulation 122(8):808-20. [PubMed: 20697023]  [MGI Ref ID J:178588]

Sun J; Sukhova GK; Wolters PJ; Yang M; Kitamoto S; Libby P; MacFarlane LA; Mallen-St Clair J; Shi GP. 2007. Mast cells promote atherosclerosis by releasing proinflammatory cytokines. Nat Med 13(6):719-24. [PubMed: 17546038]  [MGI Ref ID J:125116]

Sun L; Ishida T; Yasuda T; Kojima Y; Honjo T; Yamamoto Y; Yamamoto H; Ishibashi S; Hirata K; Hayashi Y. 2009. RAGE mediates oxidized LDL-induced pro-inflammatory effects and atherosclerosis in non-diabetic LDL receptor-deficient mice. Cardiovasc Res 82(2):371-81. [PubMed: 19176597]  [MGI Ref ID J:162198]

Surmi BK; Atkinson RD; Gruen ML; Coenen KR; Hasty AH. 2008. The role of macrophage leptin receptor in aortic root lesion formation. Am J Physiol Endocrinol Metab 294(3):E488-95. [PubMed: 18182468]  [MGI Ref ID J:133462]

Tacken PJ; Teusink B; Jong MC; Harats D; Havekes LM; van Dijk KW; Hofker MH. 2000. LDL receptor deficiency unmasks altered VLDL triglyceride metabolism in VLDL receptor transgenic and knockout mice J Lipid Res 41(12):2055-62. [PubMed: 11108739]  [MGI Ref ID J:66431]

Tadin-Strapps M; Peterson LB; Cumiskey AM; Rosa RL; Mendoza VH; Castro-Perez J; Puig O; Zhang L; Strapps WR; Yendluri S; Andrews L; Pickering V; Rice J; Luo L; Chen Z; Tep S; Ason B; Somers EP; Sachs AB; Bartz SR; Tian J; Chin J; Hubbard BK; Wong KK; Mitnaul LJ. 2011. siRNA-induced liver ApoB knockdown lowers serum LDL-cholesterol in a mouse model with human-like serum lipids. J Lipid Res 52(6):1084-97. [PubMed: 21398511]  [MGI Ref ID J:180925]

Takata Y; Liu J; Yin F; Collins AR; Lyon CJ; Lee CH; Atkins AR; Downes M; Barish GD; Evans RM; Hsueh WA; Tangirala RK. 2008. PPARdelta-mediated antiinflammatory mechanisms inhibit angiotensin II-accelerated atherosclerosis. Proc Natl Acad Sci U S A 105(11):4277-82. [PubMed: 18337495]  [MGI Ref ID J:133474]

Taleb S; Herbin O; Ait-Oufella H; Verreth W; Gourdy P; Barateau V; Merval R; Esposito B; Clement K; Holvoet P; Tedgui A; Mallat Z. 2007. Defective leptin/leptin receptor signaling improves regulatory T cell immune response and protects mice from atherosclerosis. Arterioscler Thromb Vasc Biol 27(12):2691-8. [PubMed: 17690315]  [MGI Ref ID J:147531]

Taleb S; Romain M; Ramkhelawon B; Uyttenhove C; Pasterkamp G; Herbin O; Esposito B; Perez N; Yasukawa H; Van Snick J; Yoshimura A; Tedgui A; Mallat Z. 2009. Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis. J Exp Med 206(10):2067-77. [PubMed: 19737863]  [MGI Ref ID J:153361]

Taneja D; Thompson J; Wilson P; Brandewie K; Schaefer L; Mitchell B; Tannock LR. 2010. Reversibility of renal injury with cholesterol lowering in hyperlipidemic diabetic mice. J Lipid Res 51(6):1464-70. [PubMed: 20110440]  [MGI Ref ID J:161500]

Tang EH; Shimizu K; Christen T; Rocha VZ; Shvartz E; Tesmenitsky Y; Sukhova G; Shi GP; Libby P. 2011. Lack of EP4 receptors on bone marrow-derived cells enhances inflammation in atherosclerotic lesions. Cardiovasc Res 89(1):234-43. [PubMed: 20736236]  [MGI Ref ID J:167790]

Tang EH; Shvartz E; Shimizu K; Rocha VZ; Zheng C; Fukuda D; Shi GP; Sukhova G; Libby P. 2011. Deletion of EP4 on bone marrow-derived cells enhances inflammation and angiotensin II-induced abdominal aortic aneurysm formation. Arterioscler Thromb Vasc Biol 31(2):261-9. [PubMed: 21088251]  [MGI Ref ID J:184180]

Tang JJ; Li JG; Qi W; Qiu WW; Li PS; Li BL; Song BL. 2011. Inhibition of SREBP by a small molecule, betulin, improves hyperlipidemia and insulin resistance and reduces atherosclerotic plaques. Cell Metab 13(1):44-56. [PubMed: 21195348]  [MGI Ref ID J:169478]

Tang M; Cyrus T; Yao Y; Vocun L; Pratico D. 2005. Involvement of thromboxane receptor in the proatherogenic effect of isoprostane F2alpha-III: evidence from apolipoprotein E- and LDL receptor-deficient mice. Circulation 112(18):2867-74. [PubMed: 16267259]  [MGI Ref ID J:116835]

Tang SY; Monslow J; Todd L; Lawson J; Pure E; FitzGerald GA. 2014. Cyclooxygenase-2 in endothelial and vascular smooth muscle cells restrains atherogenesis in hyperlipidemic mice. Circulation 129(17):1761-9. [PubMed: 24519928]  [MGI Ref ID J:221694]

Tangirala RK; Bischoff ED; Joseph SB; Wagner BL; Walczak R; Laffitte BA; Daige CL; Thomas D; Heyman RA; Mangelsdorf DJ; Wang X; Lusis AJ; Tontonoz P; Schulman IG. 2002. Identification of macrophage liver X receptors as inhibitors of atherosclerosis. Proc Natl Acad Sci U S A 99(18):11896-901. [PubMed: 12193651]  [MGI Ref ID J:125452]

Tangirala RK; Pratico D; FitzGerald GA; Chun S; Tsukamoto K; Maugeais C; Usher DC; Pure E; Rader DJ. 2001. Reduction of isoprostanes and regression of advanced atherosclerosis by apolipoprotein E. J Biol Chem 276(1):261-6. [PubMed: 11024044]  [MGI Ref ID J:66833]

Tangirala RK; Rubin EM; Palinski W. 1995. Quantitation of atherosclerosis in murine models: correlation between lesions in the aortic origin and in the entire aorta, and differences in the extent of lesions between sexes in LDL receptor-deficient and apolipoprotein E-deficient mice. J Lipid Res 36(11):2320-8. [PubMed: 8656070]  [MGI Ref ID J:29950]

Tanigawa H; Billheimer JT; Tohyama J; Zhang Y; Rothblat G; Rader DJ. 2007. Expression of cholesteryl ester transfer protein in mice promotes macrophage reverse cholesterol transport. Circulation 116(11):1267-73. [PubMed: 17709636]  [MGI Ref ID J:139845]

Tavori H; Fan D; Blakemore JL; Yancey PG; Ding L; Linton MF; Fazio S. 2013. Serum proprotein convertase subtilisin/kexin type 9 and cell surface low-density lipoprotein receptor: evidence for a reciprocal regulation. Circulation 127(24):2403-13. [PubMed: 23690465]  [MGI Ref ID J:211389]

Tennert C; Teupser D; Mueller MA; Wilfert W; Renner-Muller I; Stein O; Stein Y; Sippel AE; Wolf E; Thiery J. 2007. Effect of macrophage ApoE on atherosclerosis in LDL-receptor deficient mice. Biochem Biophys Res Commun 361(3):574-9. [PubMed: 17669363]  [MGI Ref ID J:124271]

Tep S; Mihaila R; Freeman A; Pickering V; Huyhn F; Tadin-Strapps M; Stracks A; Hubbard B; Caldwell J; Flanagan WM; Kuklin NA; Ason B. 2012. Rescue of Mtp siRNA-induced hepatic steatosis by DGAT2 siRNA silencing. J Lipid Res 53(5):859-67. [PubMed: 22355095]  [MGI Ref ID J:184930]

Terasaka N; Wang N; Yvan-Charvet L; Tall AR. 2007. High-density lipoprotein protects macrophages from oxidized low-density lipoprotein-induced apoptosis by promoting efflux of 7-ketocholesterol via ABCG1. Proc Natl Acad Sci U S A 104(38):15093-8. [PubMed: 17846428]  [MGI Ref ID J:125197]

Terasaka N; Yu S; Yvan-Charvet L; Wang N; Mzhavia N; Langlois R; Pagler T; Li R; Welch CL; Goldberg IJ; Tall AR. 2008. ABCG1 and HDL protect against endothelial dysfunction in mice fed a high-cholesterol diet. J Clin Invest 118(11):3701-13. [PubMed: 18924609]  [MGI Ref ID J:144580]

Terrand J; Bruban V; Zhou L; Gong W; El Asmar Z; May P; Zurhove K; Haffner P; Philippe C; Woldt E; Matz RL; Gracia C; Metzger D; Auwerx J; Herz J; Boucher P. 2009. LRP1 controls intracellular cholesterol storage and fatty acid synthesis through modulation of Wnt signaling. J Biol Chem 284(1):381-8. [PubMed: 18990694]  [MGI Ref ID J:146007]

Teupser D; Kretzschmar D; Tennert C; Burkhardt R; Wilfert W; Fengler D; Naumann R; Sippel AE; Thiery J. 2008. Effect of macrophage overexpression of murine liver X receptor-alpha (LXR-alpha) on atherosclerosis in LDL-receptor deficient mice. Arterioscler Thromb Vasc Biol 28(11):2009-15. [PubMed: 18787185]  [MGI Ref ID J:159797]

Teupser D; Pavlides S; Tan M; Gutierrez-Ramos JC; Kolbeck R; Breslow JL. 2004. Major reduction of atherosclerosis in fractalkine (CX3CL1)-deficient mice is at the brachiocephalic artery, not the aortic root. Proc Natl Acad Sci U S A 101(51):17795-800. [PubMed: 15596719]  [MGI Ref ID J:95279]

Teupser D; Tan M; Persky AD; Breslow JL. 2006. Atherosclerosis quantitative trait loci are sex- and lineage-dependent in an intercross of C57BL/6 and FVB/N low-density lipoprotein receptor-/- mice. Proc Natl Acad Sci U S A 103(1):123-8. [PubMed: 16380418]  [MGI Ref ID J:104621]

Teupser D; Weber O; Rao TN; Sass K; Thiery J; Fehling HJ. 2011. No reduction of atherosclerosis in C-reactive protein (CRP)-deficient mice. J Biol Chem 286(8):6272-9. [PubMed: 21149301]  [MGI Ref ID J:170409]

Teusink B; Mensenkamp AR; van der Boom H; Kuipers F; van Dijk KW; Havekes LM. 2001. Stimulation of the in vivo production of very low density lipoproteins by apolipoprotein E is independent of the presence of the low density lipoprotein receptor. J Biol Chem 276(44):40693-7. [PubMed: 11546779]  [MGI Ref ID J:119460]

Thatcher SE; Zhang X; Howatt DA; Lu H; Gurley SB; Daugherty A; Cassis LA. 2011. Angiotensin-converting enzyme 2 deficiency in whole body or bone marrow-derived cells increases atherosclerosis in low-density lipoprotein receptor-/- mice. Arterioscler Thromb Vasc Biol 31(4):758-65. [PubMed: 21252069]  [MGI Ref ID J:184167]

Thirumangalakudi L; Prakasam A; Zhang R; Bimonte-Nelson H; Sambamurti K; Kindy MS; Bhat NR. 2008. High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice. J Neurochem 106(1):475-85. [PubMed: 18410513]  [MGI Ref ID J:137264]

Thompson J; Wilson P; Brandewie K; Taneja D; Schaefer L; Mitchell B; Tannock LR. 2011. Renal accumulation of biglycan and lipid retention accelerates diabetic nephropathy. Am J Pathol 179(3):1179-87. [PubMed: 21723246]  [MGI Ref ID J:176327]

Thorp E; Li G; Seimon TA; Kuriakose G; Ron D; Tabas I. 2009. Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/- mice lacking CHOP. Cell Metab 9(5):474-81. [PubMed: 19416717]  [MGI Ref ID J:148485]

Tian J; Pei H; Sanders JM; Angle JF; Sarembock IJ; Matsumoto AH; Helm GA; Shi W. 2006. Hyperlipidemia is a major determinant of neointimal formation in LDL receptor-deficient mice. Biochem Biophys Res Commun 345(3):1004-9. [PubMed: 16712797]  [MGI Ref ID J:109645]

Tiebel O; Oka K; Robinson K; Sullivan M; Martinez J; Nakamuta M; Ishimura-Oka K; Chan L. 1999. Mouse very low-density lipoprotein receptor (VLDLR): gene structure, tissue-specific expression and dietary and developmental regulation. Atherosclerosis 145(2):239-51. [PubMed: 10488949]  [MGI Ref ID J:59491]

Tietge UJ; Pratico D; Ding T; Funk CD; Hildebrand RB; Van Berkel T; Van Eck M. 2005. Macrophage-specific expression of group IIA sPLA2 results in accelerated atherogenesis by increasing oxidative stress. J Lipid Res 46(8):1604-14. [PubMed: 15897607]  [MGI Ref ID J:100744]

Tilley RE; Pedersen B; Pawlinski R; Sato Y; Erlich JH; Shen Y; Day S; Huang Y; Eitzman DT; Boisvert WA; Curtiss LK; Fay WP; Mackman N. 2006. Atherosclerosis in mice is not affected by a reduction in tissue factor expression. Arterioscler Thromb Vasc Biol 26(3):555-62. [PubMed: 16385085]  [MGI Ref ID J:127980]

Tokuno S; Hinokiyama K; Tokuno K; Lowbeer C; Hansson LO; Valen G. 2002. Spontaneous ischemic events in the brain and heart adapt the hearts of severely atherosclerotic mice to ischemia. Arterioscler Thromb Vasc Biol 22(6):995-1001. [PubMed: 12067910]  [MGI Ref ID J:102937]

Towler DA; Bidder M; Latifi T; Coleman T; Semenkovich CF. 1998. Diet-induced diabetes activates an osteogenic gene regulatory program in the aortas of low density lipoprotein receptor-deficient mice. J Biol Chem 273(46):30427-34. [PubMed: 9804809]  [MGI Ref ID J:50962]

Tozawa R; Ishibashi S; Osuga J; Yagyu H; Oka T; Chen Z; Ohashi K; Perrey S; Shionoiri F; Yahagi N; Harada K; Gotoda T; Yazaki Y; Yamada N. 1999. Embryonic lethality and defective neural tube closure in mice lacking squalene synthase. J Biol Chem 274(43):30843-8. [PubMed: 10521476]  [MGI Ref ID J:58231]

Truong TQ; Auger A; Denizeau F; Brissette L. 2000. Analysis of low-density lipoprotein catabolism by primary cultures of hepatic cells from normal and low-density lipoprotein receptor knockout mice. Biochim Biophys Acta 1484(2-3):307-15. [PubMed: 10760479]  [MGI Ref ID J:61821]

Tsai SH; Huang PH; Peng YJ; Chang WC; Tsai HY; Leu HB; Chen JW; Lin SJ. 2013. Zoledronate attenuates angiotensin II-induced abdominal aortic aneurysm through inactivation of Rho/ROCK-dependent JNK and NF-kappaB pathway. Cardiovasc Res 100(3):501-10. [PubMed: 24225494]  [MGI Ref ID J:219537]

Tsuchiya K; Westerterp M; Murphy AJ; Subramanian V; Ferrante AW Jr; Tall AR; Accili D. 2013. Expanded granulocyte/monocyte compartment in myeloid-specific triple FoxO knockout increases oxidative stress and accelerates atherosclerosis in mice. Circ Res 112(7):992-1003. [PubMed: 23420833]  [MGI Ref ID J:213325]

Tu P; Bhasin S; Hruz PW; Herbst KL; Castellani LW; Hua N; Hamilton JA; Guo W. 2009. Genetic disruption of myostatin reduces the development of proatherogenic dyslipidemia and atherogenic lesions in Ldlr null mice. Diabetes 58(8):1739-48. [PubMed: 19509018]  [MGI Ref ID J:154414]

Twisk J; Gillian-Daniel DL; Tebon A; Wang L; Barrett PH; Attie AD. 2000. The role of the LDL receptor in apolipoprotein B secretion. J Clin Invest 105(4):521-32. [PubMed: 10683382]  [MGI Ref ID J:60664]

Uchida HA; Poduri A; Subramanian V; Cassis LA; Daugherty A. 2011. Urokinase-type plasminogen activator deficiency in bone marrow-derived cells augments rupture of angiotensin II-induced abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol 31(12):2845-52. [PubMed: 21868698]  [MGI Ref ID J:191466]

Umans L; Overbergh L; Serneels L; Tesseur I; Van Leuven F. 1999. Analysis of expression of genes involved in apolipoprotein E-based lipoprotein metabolism in pregnant mice deficient in the receptor-associated protein, the low density lipoprotein receptor, or apolipoprotein E. Biol Reprod 61(5):1216-25. [PubMed: 10529267]  [MGI Ref ID J:107547]

Umemoto T; Han CY; Mitra P; Averill MM; Tang C; Goodspeed L; Omer M; Subramanian S; Wang S; Den Hartigh LJ; Wei H; Kim EJ; Kim J; O'Brien KD; Chait A. 2013. Apolipoprotein AI and high-density lipoprotein have anti-inflammatory effects on adipocytes via cholesterol transporters: ATP-binding cassette A-1, ATP-binding cassette G-1, and scavenger receptor B-1. Circ Res 112(10):1345-54. [PubMed: 23501697]  [MGI Ref ID J:213314]

Valenta DT; Bulgrien JJ; Bonnet DJ; Curtiss LK. 2008. Macrophage PLTP is atheroprotective in LDLr-deficient mice with systemic PLTP deficiency. J Lipid Res 49(1):24-32. [PubMed: 17928634]  [MGI Ref ID J:130081]

Van Eck M; Bos IS; Hildebrand RB; Van Rij BT; Van Berkel TJ. 2004. Dual role for scavenger receptor class B, type I on bone marrow-derived cells in atherosclerotic lesion development. Am J Pathol 165(3):785-94. [PubMed: 15331403]  [MGI Ref ID J:92320]

Van Eck M; Ye D; Hildebrand RB; Kar Kruijt J; de Haan W; Hoekstra M; Rensen PC; Ehnholm C; Jauhiainen M; Van Berkel TJ. 2007. Important role for bone marrow-derived cholesteryl ester transfer protein in lipoprotein cholesterol redistribution and atherosclerotic lesion development in LDL receptor knockout mice. Circ Res 100(5):678-85. [PubMed: 17293475]  [MGI Ref ID J:133704]

Van den Bergh A; Vanderper A; Vangheluwe P; Desjardins F; Nevelsteen I; Verreth W; Wuytack F; Holvoet P; Flameng W; Balligand JL; Herijgers P. 2008. Dyslipidaemia in type II diabetic mice does not aggravate contractile impairment but increases ventricular stiffness. Cardiovasc Res 77(2):371-9. [PubMed: 18006491]  [MGI Ref ID J:161915]

VanderLaan PA; Reardon CA; Thisted RA; Getz GS. 2009. VLDL best predicts aortic root atherosclerosis in LDL receptor deficient mice. J Lipid Res 50(3):376-85. [PubMed: 18957695]  [MGI Ref ID J:149089]

Varadhachary AS; Monestier M; Salgame P. 2001. Reciprocal induction of IL-10 and IL-12 from macrophages by low-density lipoprotein and its oxidized forms. Cell Immunol 213(1):45-51. [PubMed: 11747355]  [MGI Ref ID J:115363]

Vasandani C; Kafrouni AI; Caronna A; Bashmakov Y; Gotthardt M; Horton JD; Spady DK. 2002. Upregulation of hepatic LDL transport by n-3 fatty acids in LDL receptor knockout mice. J Lipid Res 43(5):772-84. [PubMed: 11971949]  [MGI Ref ID J:124748]

Veniant MM; Sullivan MA; Kim SK; Ambroziak P; Chu A; Wilson MD; Hellerstein MK; Rudel LL; Walzem RL; Young SG. 2000. Defining the atherogenicity of large and small lipoproteins containing apolipoprotein B100 J Clin Invest 106(12):1501-10. [PubMed: 11120757]  [MGI Ref ID J:66424]

Veniant MM; Zlot CH; Walzem RL; Pierotti V; Driscoll R; Dichek D ; Herz J ; Young SG. 1998. Lipoprotein clearance mechanisms in LDL receptor-deficient Apo-B48-only and Apo-B100-only mice. J Clin Invest 102(8):1559-68. [PubMed: 9788969]  [MGI Ref ID J:51022]

Verschuren L; Kooistra T; Bernhagen J; Voshol PJ; Ouwens DM; van Erk M; de Vries-van der Weij J; Leng L; van Bockel JH; van Dijk KW; Fingerle-Rowson G; Bucala R; Kleemann R. 2009. MIF deficiency reduces chronic inflammation in white adipose tissue and impairs the development of insulin resistance, glucose intolerance, and associated atherosclerotic disease. Circ Res 105(1):99-107. [PubMed: 19478200]  [MGI Ref ID J:164757]

Vikramadithyan RK; Hu Y; Noh HL; Liang CP; Hallam K; Tall AR; Ramasamy R; Goldberg IJ. 2005. Human aldose reductase expression accelerates diabetic atherosclerosis in transgenic mice. J Clin Invest 115(9):2434-43. [PubMed: 16127462]  [MGI Ref ID J:100916]

Vikramadithyan RK; Kako Y; Chen G; Hu Y; Arikawa-Hirasawa E; Yamada Y; Goldberg IJ. 2004. Atherosclerosis in perlecan heterozygous mice. J Lipid Res 45(10):1806-12. [PubMed: 15258195]  [MGI Ref ID J:93619]

Vikstedt R; Ye D; Metso J; Hildebrand RB; Van Berkel TJ; Ehnholm C; Jauhiainen M; Van Eck M. 2007. Macrophage phospholipid transfer protein contributes significantly to total plasma phospholipid transfer activity and its deficiency leads to diminished atherosclerotic lesion development. Arterioscler Thromb Vasc Biol 27(3):578-86. [PubMed: 17170377]  [MGI Ref ID J:148673]

Von Der Thusen JH; Kuiper J; Fekkes ML; De Vos P; Van Berkel TJ; Biessen EA. 2001. Attenuation of atherogenesis by systemic and local adenovirus-mediated gene transfer of interleukin-10 in LDLr-/- mice. FASEB J 15(14):2730-2. [PubMed: 11687507]  [MGI Ref ID J:73161]

Voorend M; van der Ven AJ; Mulder M; Lodder J; Steinbusch HW; Bruggeman CA. 2010. Chlamydia pneumoniae infection enhances microglial activation in atherosclerotic mice. Neurobiol Aging 31(10):1766-73. [PubMed: 19027992]  [MGI Ref ID J:165244]

Wang J; Sjoberg S; Tang TT; Oorni K; Wu W; Liu C; Secco B; Tia V; Sukhova GK; Fernandes C; Lesner A; Kovanen PT; Libby P; Cheng X; Shi GP. 2014. Cathepsin G activity lowers plasma LDL and reduces atherosclerosis. Biochim Biophys Acta 1842(11):2174-83. [PubMed: 25092171]  [MGI Ref ID J:218470]

Wang M; Lee E; Song W; Ricciotti E; Rader DJ; Lawson JA; Pure E; FitzGerald GA. 2008. Microsomal prostaglandin E synthase-1 deletion suppresses oxidative stress and angiotensin II-induced abdominal aortic aneurysm formation. Circulation 117(10):1302-9. [PubMed: 18285567]  [MGI Ref ID J:148450]

Wang M; Zukas AM; Hui Y; Ricciotti E; Pure E; FitzGerald GA. 2006. Deletion of microsomal prostaglandin E synthase-1 augments prostacyclin and retards atherogenesis. Proc Natl Acad Sci U S A 103(39):14507-12. [PubMed: 16973753]  [MGI Ref ID J:114545]

Wang MD; Kiss RS; Franklin V; McBride HM; Whitman SC; Marcel YL. 2007. Different cellular traffic of LDL-cholesterol and acetylated LDL-cholesterol leads to distinct reverse cholesterol transport pathways. J Lipid Res 48(3):633-45. [PubMed: 17148552]  [MGI Ref ID J:120283]

Wang S; Zhang M; Liang B; Xu J; Xie Z; Liu C; Viollet B; Yan D; Zou MH. 2010. AMPKalpha2 deletion causes aberrant expression and activation of NAD(P)H oxidase and consequent endothelial dysfunction in vivo: role of 26S proteasomes. Circ Res 106(6):1117-28. [PubMed: 20167927]  [MGI Ref ID J:171036]

Wang Z; Nicholls SJ; Rodriguez ER; Kummu O; Horkko S; Barnard J; Reynolds WF; Topol EJ; DiDonato JA; Hazen SL. 2007. Protein carbamylation links inflammation, smoking, uremia and atherogenesis. Nat Med 13(10):1176-84. [PubMed: 17828273]  [MGI Ref ID J:129923]

Wang ZH; Shang YY; Zhang S; Zhong M; Wang XP; Deng JT; Pan J; Zhang Y; Zhang W. 2012. Silence of TRIB3 suppresses atherosclerosis and stabilizes plaques in diabetic ApoE-/-/LDL receptor-/- mice. Diabetes 61(2):463-73. [PubMed: 22275087]  [MGI Ref ID J:196759]

Wanschel A; Seibert T; Hewing B; Ramkhelawon B; Ray TD; van Gils JM; Rayner KJ; Feig JE; O'Brien ER; Fisher EA; Moore KJ. 2013. Neuroimmune guidance cue Semaphorin 3E is expressed in atherosclerotic plaques and regulates macrophage retention. Arterioscler Thromb Vasc Biol 33(5):886-93. [PubMed: 23430613]  [MGI Ref ID J:217969]

Webb NR; Bostrom MA; Szilvassy SJ; van der Westhuyzen DR; Daugherty A; de Beer FC. 2003. Macrophage-expressed group IIA secretory phospholipase A2 increases atherosclerotic lesion formation in LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol 23(2):263-8. [PubMed: 12588769]  [MGI Ref ID J:127990]

Weber C; Meiler S; Doring Y; Koch M; Drechsler M; Megens RT; Rowinska Z; Bidzhekov K; Fecher C; Ribechini E; van Zandvoort MA; Binder CJ; Jelinek I; Hristov M; Boon L; Jung S; Korn T; Lutz MB; Forster I; Zenke M; Hieronymus T; Junt T; Zernecke A. 2011. CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice. J Clin Invest 121(7):2898-910. [PubMed: 21633167]  [MGI Ref ID J:175665]

Wei S; Wang H; Zhang G; Lu Y; An X; Ren S; Wang Y; Chen Y; White JG; Zhang C; Simon DI; Wu C; Li Z; Huo Y. 2013. Platelet IkappaB kinase-beta deficiency increases mouse arterial neointima formation via delayed glycoprotein Ibalpha shedding. Arterioscler Thromb Vasc Biol 33(2):241-8. [PubMed: 23241410]  [MGI Ref ID J:216903]

Weng S; Sprague JE; Oh J; Riek AE; Chin K; Garcia M; Bernal-Mizrachi C. 2013. Vitamin D deficiency induces high blood pressure and accelerates atherosclerosis in mice. PLoS One 8(1):e54625. [PubMed: 23349943]  [MGI Ref ID J:195839]

Weng S; Zemany L; Standley KN; Novack DV; La Regina M; Bernal-Mizrachi C; Coleman T; Semenkovich CF. 2003. Beta3 integrin deficiency promotes atherosclerosis and pulmonary inflammation in high-fat-fed, hyperlipidemic mice. Proc Natl Acad Sci U S A 100(11):6730-5. [PubMed: 12746502]  [MGI Ref ID J:83615]

Westerterp M; Koetsveld J; Yu S; Han S; Li R; Goldberg IJ; Welch CL; Tall AR. 2010. Increased atherosclerosis in mice with vascular ATP-binding cassette transporter G1 deficiency--brief report. Arterioscler Thromb Vasc Biol 30(11):2103-5. [PubMed: 20705913]  [MGI Ref ID J:183210]

Westerterp M; Murphy AJ; Wang M; Pagler TA; Vengrenyuk Y; Kappus MS; Gorman DJ; Nagareddy PR; Zhu X; Abramowicz S; Parks JS; Welch C; Fisher EA; Wang N; Yvan-Charvet L; Tall AR. 2013. Deficiency of ATP-binding cassette transporters A1 and G1 in macrophages increases inflammation and accelerates atherosclerosis in mice. Circ Res 112(11):1456-65. [PubMed: 23572498]  [MGI Ref ID J:213300]

Westmuckett AD; Moore KL. 2009. Lack of tyrosylprotein sulfotransferase activity in hematopoietic cells drastically attenuates atherosclerosis in Ldlr-/- mice. Arterioscler Thromb Vasc Biol 29(11):1730-6. [PubMed: 19679829]  [MGI Ref ID J:167800]

Whitman SC; Rateri DL; Szilvassy SJ; Cornicelli JA; Daugherty A. 2002. Macrophage-specific expression of class A scavenger receptors in LDL receptor(-/-) mice decreases atherosclerosis and changes spleen morphology. J Lipid Res 43(8):1201-8. [PubMed: 12177164]  [MGI Ref ID J:78922]

Wilck N; Fechner M; Dreger H; Hewing B; Arias A; Meiners S; Baumann G; Stangl V; Stangl K; Ludwig A. 2012. Attenuation of early atherogenesis in low-density lipoprotein receptor-deficient mice by proteasome inhibition. Arterioscler Thromb Vasc Biol 32(6):1418-26. [PubMed: 22516063]  [MGI Ref ID J:197090]

Wilhelm AJ; Zabalawi M; Grayson JM; Weant AE; Major AS; Owen J; Bharadwaj M; Walzem R; Chan L; Oka K; Thomas MJ; Sorci-Thomas MG. 2009. Apolipoprotein A-I and its role in lymphocyte cholesterol homeostasis and autoimmunity. Arterioscler Thromb Vasc Biol 29(6):843-9. [PubMed: 19286630]  [MGI Ref ID J:162193]

Wilhelm AJ; Zabalawi M; Owen JS; Shah D; Grayson JM; Major AS; Bhat S; Gibbs DP Jr; Thomas MJ; Sorci-Thomas MG. 2010. Apolipoprotein A-I modulates regulatory T cells in autoimmune LDLr-/-, ApoA-I-/- mice. J Biol Chem 285(46):36158-69. [PubMed: 20833724]  [MGI Ref ID J:166862]

Willnow TE; Armstrong SA; Hammer RE; Herz J. 1995. Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo. Proc Natl Acad Sci U S A 92(10):4537-41. [PubMed: 7538675]  [MGI Ref ID J:43736]

Wilund KR; Yu L; Xu F; Hobbs HH; Cohen JC. 2004. High-level expression of ABCG5 and ABCG8 attenuates diet-induced hypercholesterolemia and atherosclerosis in Ldlr-/- mice. J Lipid Res 45(8):1429-36. [PubMed: 15175362]  [MGI Ref ID J:91353]

Witting PK; Pettersson K; Ostlund-Lindqvist AM; Westerlund C; Eriksson AW; Stocker R. 1999. Inhibition by a coantioxidant of aortic lipoprotein lipid peroxidation and atherosclerosis in apolipoprotein E and low density lipoprotein receptor gene double knockout mice. FASEB J 13(6):667-75. [PubMed: 10094927]  [MGI Ref ID J:54037]

Wolfrum C; Poy MN; Stoffel M. 2005. Apolipoprotein M is required for prebeta-HDL formation and cholesterol efflux to HDL and protects against atherosclerosis. Nat Med 11(4):418-22. [PubMed: 15793583]  [MGI Ref ID J:97550]

Wong CW; Burger F; Pelli G; Mach F; Kwak BR. 2003. Dual benefit of reduced Cx43 on atherosclerosis in LDL receptor-deficient mice. Cell Commun Adhes 10(4-6):395-400. [PubMed: 14681047]  [MGI Ref ID J:103076]

Wouters K; van Bilsen M; van Gorp PJ; Bieghs V; Lutjohann D; Kerksiek A; Staels B; Hofker MH; Shiri-Sverdlov R. 2010. Intrahepatic cholesterol influences progression, inhibition and reversal of non-alcoholic steatohepatitis in hyperlipidemic mice. FEBS Lett 584(5):1001-5. [PubMed: 20114046]  [MGI Ref ID J:157585]

Wu D; Yang H; Xiang W; Zhou L; Shi M; Julies G; Laplante JM; Ballard BR; Guo Z. 2005. Heterozygous mutation of ataxia-telangiectasia mutated gene aggravates hypercholesterolemia in apoE-deficient mice. J Lipid Res 46(7):1380-7. [PubMed: 15863839]  [MGI Ref ID J:100500]

Wu JE; Basso F; Shamburek RD; Amar MJ; Vaisman B; Szakacs G; Joyce C; Tansey T; Freeman L; Paigen BJ; Thomas F; Brewer HB Jr; Santamarina-Fojo S. 2004. Hepatic ABCG5 and ABCG8 overexpression increases hepatobiliary sterol transport but does not alter aortic atherosclerosis in transgenic mice. J Biol Chem 279(22):22913-25. [PubMed: 15044450]  [MGI Ref ID J:90718]

Wu L; Vikramadithyan R; Yu S; Pau C; Hu Y; Goldberg IJ; Dansky HM. 2006. Addition of dietary fat to cholesterol in the diets of LDL receptor knockout mice: effects on plasma insulin, lipoproteins, and atherosclerosis. J Lipid Res 47(10):2215-22. [PubMed: 16840797]  [MGI Ref ID J:116491]

Xanthoulea S; Thelen M; Pottgens C; Gijbels MJ; Lutgens E; de Winther MP. 2009. Absence of p55 TNF receptor reduces atherosclerosis, but has no major effect on angiotensin II induced aneurysms in LDL receptor deficient mice. PLoS One 4(7):e6113. [PubMed: 19582157]  [MGI Ref ID J:151487]

Xia M; Chen D; Endresz V; Faludi I; Szabo A; Gonczol E; Kakkar V; Lu X. 2013. Immunization of Chlamydia pneumoniae (Cpn)-infected Apob(tm2Sgy)Ldlr(tm1Her)/J mice with a combined peptide of Cpn significantly reduces atherosclerotic lesion development. PLoS One 8(12):e81056. [PubMed: 24349031]  [MGI Ref ID J:211155]

Xie C; Burns DK; Turley SD; Dietschy JM. 2000. Cholesterol is sequestered in the brains of mice with Niemann-Pick type C disease but turnover is increased. J Neuropathol Exp Neurol 59(12):1106-17. [PubMed: 11138930]  [MGI Ref ID J:104996]

Xie C; Richardson JA; Turley SD; Dietschy JM. 2006. Cholesterol substrate pools and steroid hormone levels are normal in the face of mutational inactivation of NPC1 protein. J Lipid Res 47(5):953-63. [PubMed: 16461760]  [MGI Ref ID J:109000]

Xie C; Turley SD; Dietschy JM. 2000. Centripetal cholesterol flow from the extrahepatic organs through the liver is normal in mice with mutated niemann-pick type C protein (NPC1) J Lipid Res 41(8):1278-89. [PubMed: 10946016]  [MGI Ref ID J:64028]

Xie C; Turley SD; Dietschy JM. 1999. Cholesterol accumulation in tissues of the Niemann-pick type C mouse is determined by the rate of lipoprotein-cholesterol uptake through the coated-pit pathway in each organ. Proc Natl Acad Sci U S A 96(21):11992-7. [PubMed: 10518564]  [MGI Ref ID J:76735]

Xu Y; Arai H; Murayama T; Kita T; Yokode M. 2007. Hypercholesterolemia contributes to the development of atherosclerosis and vascular remodeling by recruiting bone marrow-derived cells in cuff-induced vascular injury. Biochem Biophys Res Commun 363(3):782-7. [PubMed: 17897625]  [MGI Ref ID J:127338]

Yagyu H; Kitamine T; Osuga J; Tozawa R; Chen Z; Kaji Y; Oka T; Perrey S; Tamura Y; Ohashi K; Okazaki H; Yahagi N; Shionoiri F; Iizuka Y; Harada K; Shimano H; Yamashita H; Gotoda T; Yamada N; Ishibashi S. 2000. Absence of ACAT-1 attenuates atherosclerosis but causes dry eye and cutaneous xanthomatosis in mice with congenital hyperlipidemia. J Biol Chem 275(28):21324-30. [PubMed: 10777503]  [MGI Ref ID J:63468]

Yan D; Jauhiainen M; Hildebrand RB; Willems van Dijk K; Van Berkel TJ; Ehnholm C; Van Eck M; Olkkonen VM. 2007. Expression of human OSBP-related protein 1L in macrophages enhances atherosclerotic lesion development in LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol 27(7):1618-24. [PubMed: 17478758]  [MGI Ref ID J:134908]

Yan D; Navab M; Bruce C; Fogelman AM; Jiang XC. 2004. PLTP deficiency improves the anti-inflammatory properties of HDL and reduces the ability of LDL to induce monocyte chemotactic activity. J Lipid Res 45(10):1852-8. [PubMed: 15258196]  [MGI Ref ID J:93620]

Yancey PG; Ding Y; Fan D; Blakemore JL; Zhang Y; Ding L; Zhang J; Linton MF; Fazio S. 2011. Low-density lipoprotein receptor-related protein 1 prevents early atherosclerosis by limiting lesional apoptosis and inflammatory Ly-6Chigh monocytosis: evidence that the effects are not apolipoprotein E dependent. Circulation 124(4):454-64. [PubMed: 21730304]  [MGI Ref ID J:186294]

Yang X; Peterson L; Thieringer R; Deignan JL; Wang X; Zhu J; Wang S; Zhong H; Stepaniants S; Beaulaurier J; Wang IM; Rosa R; Cumiskey AM; Luo JM; Luo Q; Shah K; Xiao J; Nickle D; Plump A; Schadt EE; Lusis AJ; Lum PY. 2010. Identification and validation of genes affecting aortic lesions in mice. J Clin Invest 120(7):2414-22. [PubMed: 20577049]  [MGI Ref ID J:163781]

Ye D; Meurs I; Ohigashi M; Calpe-Berdiel L; Habets KL; Zhao Y; Kubo Y; Yamaguchi A; Van Berkel TJ; Nishi T; Van Eck M. 2010. Macrophage ABCA5 deficiency influences cellular cholesterol efflux and increases susceptibility to atherosclerosis in female LDLr knockout mice. Biochem Biophys Res Commun 395(3):387-94. [PubMed: 20382126]  [MGI Ref ID J:160341]

Ye D; Zhao Y; Hildebrand RB; Singaraja RR; Hayden MR; Van Berkel TJ; Van Eck M. 2011. The dynamics of macrophage infiltration into the arterial wall during atherosclerotic lesion development in low-density lipoprotein receptor knockout mice. Am J Pathol 178(1):413-22. [PubMed: 21224078]  [MGI Ref ID J:168077]

Yen FT; Roitel O; Bonnard L; Notet V; Pratte D; Stenger C; Magueur E; Bihain BE. 2008. Lipolysis stimulated lipoprotein receptor: a novel molecular link between hyperlipidemia, weight gain, and atherosclerosis in mice. J Biol Chem 283(37):25650-9. [PubMed: 18644789]  [MGI Ref ID J:142162]

Yokoyama M; Seo T; Park T; Yagyu H; Hu Y; Son NH; Augustus AS; Vikramadithyan RK; Ramakrishnan R; Pulawa LK; Eckel RH; Goldberg IJ. 2007. Effects of lipoprotein lipase and statins on cholesterol uptake into heart and skeletal muscle. J Lipid Res 48(3):646-55. [PubMed: 17189607]  [MGI Ref ID J:120271]

Yoon J; Subramanian S; Ding Y; Wang S; Goodspeed L; Sullivan B; Kim J; O'Brien KD; Chait A. 2011. Chronic insulin therapy reduces adipose tissue macrophage content in LDL-receptor-deficient mice. Diabetologia :. [PubMed: 21327868]  [MGI Ref ID J:169596]

Yoshimatsu M; Terasaki Y; Sakashita N; Kiyota E; Sato H; van der Laan LJ; Takeya M. 2004. Induction of macrophage scavenger receptor MARCO in nonalcoholic steatohepatitis indicates possible involvement of endotoxin in its pathogenic process. Int J Exp Pathol 85(6):335-43. [PubMed: 15566430]  [MGI Ref ID J:104609]

Yu F; Du F; Wang Y; Huang S; Miao R; Major AS; Murphy EA; Fu M; Fan D. 2013. Bone marrow deficiency of MCPIP1 results in severe multi-organ inflammation but diminishes atherogenesis in hyperlipidemic mice. PLoS One 8(11):e80089. [PubMed: 24223214]  [MGI Ref ID J:209217]

Yu KC; Chen W; Cooper AD. 2001. LDL receptor-related protein mediates cell-surface clustering and hepatic sequestration of chylomicron remnants in LDLR-deficient mice. J Clin Invest 107(11):1387-94. [PubMed: 11390420]  [MGI Ref ID J:69912]

Yu KC; Jiang Y; Chen W; Cooper AD. 2000. Rapid initial removal of chylomicron remnants by the mouse liver does not require hepatically localized apolipoprotein E J Lipid Res 41(11):1715-27. [PubMed: 11060341]  [MGI Ref ID J:65695]

Yu Y; Lucitt MB; Stubbe J; Cheng Y; Friis UG; Hansen PB; Jensen BL; Smyth EM; FitzGerald GA. 2009. Prostaglandin F2alpha elevates blood pressure and promotes atherosclerosis. Proc Natl Acad Sci U S A 106(19):7985-90. [PubMed: 19416858]  [MGI Ref ID J:148401]

Yvan-Charvet L; Pagler T; Gautier EL; Avagyan S; Siry RL; Han S; Welch CL; Wang N; Randolph GJ; Snoeck HW; Tall AR. 2010. ATP-binding cassette transporters and HDL suppress hematopoietic stem cell proliferation. Science 328(5986):1689-93. [PubMed: 20488992]  [MGI Ref ID J:161310]

Yvan-Charvet L; Ranalletta M; Wang N; Han S; Terasaka N; Li R; Welch C; Tall AR. 2007. Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice. J Clin Invest 117(12):3900-8. [PubMed: 17992262]  [MGI Ref ID J:130777]

Zabalawi M; Bharadwaj M; Horton H; Cline M; Willingham M; Thomas MJ; Sorci-Thomas MG. 2007. Inflammation and skin cholesterol in LDLr-/-, apoA-I-/- mice: link between cholesterol homeostasis and self-tolerance? J Lipid Res 48(1):52-65. [PubMed: 17071966]  [MGI Ref ID J:117480]

Zabalawi M; Bhat S; Loughlin T; Thomas MJ; Alexander E; Cline M; Bullock B; Willingham M; Sorci-Thomas MG. 2003. Induction of fatal inflammation in LDL receptor and ApoA-I double-knockout mice fed dietary fat and cholesterol. Am J Pathol 163(3):1201-13. [PubMed: 12937162]  [MGI Ref ID J:85174]

Zaid A; Roubtsova A; Essalmani R; Marcinkiewicz J; Chamberland A; Hamelin J; Tremblay M; Jacques H; Jin W; Davignon J; Seidah NG; Prat A. 2008. Proprotein convertase subtilisin/kexin type 9 (PCSK9): hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration. Hepatology 48(2):646-54. [PubMed: 18666258]  [MGI Ref ID J:169834]

Zernecke A; Bot I; Djalali-Talab Y; Shagdarsuren E; Bidzhekov K; Meiler S; Krohn R; Schober A; Sperandio M; Soehnlein O; Bornemann J; Tacke F; Biessen EA; Weber C. 2008. Protective role of CXC receptor 4/CXC ligand 12 unveils the importance of neutrophils in atherosclerosis. Circ Res 102(2):209-17. [PubMed: 17991882]  [MGI Ref ID J:145593]

Zhang C; An J; Strickland DK; Yepes M. 2009. The low-density lipoprotein receptor-related protein 1 mediates tissue-type plasminogen activator-induced microglial activation in the ischemic brain. Am J Pathol 174(2):586-94. [PubMed: 19147818]  [MGI Ref ID J:144185]

Zhang D; Fang P; Jiang X; Nelson J; Moore JK; Kruger WD; Berretta RM; Houser SR; Yang X; Wang H. 2012. Severe hyperhomocysteinemia promotes bone marrow-derived and resident inflammatory monocyte differentiation and atherosclerosis in LDLr/CBS-deficient mice. Circ Res 111(1):37-49. [PubMed: 22628578]  [MGI Ref ID J:212656]

Zhang WJ; Bird KE; McMillen TS; LeBoeuf RC; Hagen TM; Frei B. 2008. Dietary alpha-lipoic acid supplementation inhibits atherosclerotic lesion development in apolipoprotein E-deficient and apolipoprotein E/low-density lipoprotein receptor-deficient mice. Circulation 117(3):421-8. [PubMed: 18158360]  [MGI Ref ID J:145089]

Zhang X; Thatcher SE; Rateri DL; Bruemmer D; Charnigo R; Daugherty A; Cassis LA. 2012. Transient exposure of neonatal female mice to testosterone abrogates the sexual dimorphism of abdominal aortic aneurysms. Circ Res 110(11):e73-85. [PubMed: 22539767]  [MGI Ref ID J:212660]

Zhang Y; Breevoort SR; Angdisen J; Fu M; Schmidt DR; Holmstrom SR; Kliewer SA; Mangelsdorf DJ; Schulman IG. 2012. Liver LXRalpha expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice. J Clin Invest 122(5):1688-99. [PubMed: 22484817]  [MGI Ref ID J:184536]

Zhang Y; Wang X; Vales C; Lee FY; Lee H; Lusis AJ; Edwards PA. 2006. FXR deficiency causes reduced atherosclerosis in Ldlr-/- mice. Arterioscler Thromb Vasc Biol 26(10):2316-21. [PubMed: 16825595]  [MGI Ref ID J:128055]

Zhao B; Song J; Chow WN; St Clair RW; Rudel LL; Ghosh S. 2007. Macrophage-specific transgenic expression of cholesteryl ester hydrolase significantly reduces atherosclerosis and lesion necrosis in Ldlr mice. J Clin Invest 117(10):2983-92. [PubMed: 17885686]  [MGI Ref ID J:127535]

Zhao L; Cuff CA; Moss E; Wille U; Cyrus T; Klein EA; Pratico D; Rader DJ; Hunter CA; Pure E; Funk CD. 2002. Selective interleukin-12 synthesis defect in 12/15-lipoxygenase-deficient macrophages associated with reduced atherosclerosis in a mouse model of familial hypercholesterolemia. J Biol Chem 277(38):35350-6. [PubMed: 12122008]  [MGI Ref ID J:79120]

Zhao Y; Pennings M; Hildebrand RB; Ye D; Calpe-Berdiel L; Out R; Kjerrulf M; Hurt-Camejo E; Groen AK; Hoekstra M; Jessup W; Chimini G; Van Berkel TJ; Van Eck M. 2010. Enhanced foam cell formation, atherosclerotic lesion development, and inflammation by combined deletion of ABCA1 and SR-BI in Bone marrow-derived cells in LDL receptor knockout mice on western-type diet. Circ Res 107(12):e20-31. [PubMed: 21071707]  [MGI Ref ID J:178508]

Zhao Y; Su B; Jacobs RL; Kennedy B; Francis GA; Waddington E; Brosnan JT; Vance JE; Vance DE. 2009. Lack of phosphatidylethanolamine N-methyltransferase alters plasma VLDL phospholipids and attenuates atherosclerosis in mice. Arterioscler Thromb Vasc Biol 29(9):1349-55. [PubMed: 19520976]  [MGI Ref ID J:167813]

Zhao Y; Ye D; Wang J; Calpe-Berdiel L; Azzis SB; Van Berkel TJ; Van Eck M. 2011. Stage-specific remodeling of atherosclerotic lesions upon cholesterol lowering in LDL receptor knockout mice. Am J Pathol 179(3):1522-32. [PubMed: 21741939]  [MGI Ref ID J:179953]

Zhou C; Pridgen B; King N; Xu J; Breslow JL. 2011. Hyperglycemic Ins2AkitaLdlr-/- mice show severely elevated lipid levels and increased atherosclerosis: a model of type 1 diabetic macrovascular disease. J Lipid Res 52(8):1483-93. [PubMed: 21606463]  [MGI Ref ID J:174983]

Zhou L; Choi HY; Li WP; Xu F; Herz J. 2009. LRP1 controls cPLA2 phosphorylation, ABCA1 expression and cellular cholesterol export. PLoS One 4(8):e6853. [PubMed: 19718435]  [MGI Ref ID J:152391]

Zhou L; Takayama Y; Boucher P; Tallquist MD; Herz J. 2009. LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation. PLoS One 4(9):e6922. [PubMed: 19742316]  [MGI Ref ID J:153626]

Zhou L; Yang H; Lin X; Okoro EU; Guo Z. 2012. Cholecystokinin elevates mouse plasma lipids. PLoS One 7(12):e51011. [PubMed: 23300532]  [MGI Ref ID J:195734]

Zhou L; Yang H; Okoro EU; Guo Z. 2014. Up-regulation of cholesterol absorption is a mechanism for cholecystokinin-induced hypercholesterolemia. J Biol Chem 289(19):12989-99. [PubMed: 24692543]  [MGI Ref ID J:214128]

Zhou Q; Mei Y; Shoji T; Han X; Kaminski K; Oh GT; Ongusaha PP; Zhang K; Schmitt H; Moser M; Bode C; Liao JK. 2012. Rho-associated coiled-coil-containing kinase 2 deficiency in bone marrow-derived cells leads to increased cholesterol efflux and decreased atherosclerosis. Circulation 126(18):2236-47. [PubMed: 23011471]  [MGI Ref ID J:210071]

Zhou X; He W; Huang Z; Gotto AM Jr; Hajjar DP; Han J. 2008. Genetic deletion of low density lipoprotein receptor impairs sterol-induced mouse macrophage ABCA1 expression. A new SREBP1-dependent mechanism. J Biol Chem 283(4):2129-38. [PubMed: 18029360]  [MGI Ref ID J:130725]

Zhu L; Stalker TJ; Fong KP; Jiang H; Tran A; Crichton I; Lee EK; Neeves KB; Maloney SF; Kikutani H; Kumanogoh A; Pure E; Diamond SL; Brass LF. 2009. Disruption of SEMA4D ameliorates platelet hypersensitivity in dyslipidemia and confers protection against the development of atherosclerosis. Arterioscler Thromb Vasc Biol 29(7):1039-45. [PubMed: 19390055]  [MGI Ref ID J:167817]

Zhu SN; Chen M; Jongstra-Bilen J; Cybulsky MI. 2009. GM-CSF regulates intimal cell proliferation in nascent atherosclerotic lesions. J Exp Med 206(10):2141-9. [PubMed: 19752185]  [MGI Ref ID J:153507]

Zirlik A; Maier C; Gerdes N; MacFarlane L; Soosairajah J; Bavendiek U; Ahrens I; Ernst S; Bassler N; Missiou A; Patko Z; Aikawa M; Schonbeck U; Bode C; Libby P; Peter K. 2007. CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1. Circulation 115(12):1571-80. [PubMed: 17372166]  [MGI Ref ID J:133045]

Zotes TM; Arias CF; Fuster JJ; Spada R; Perez-Yague S; Hirsch E; Wymann M; Carrera AC; Andres V; Barber DF. 2013. PI3K p110gamma deletion attenuates murine atherosclerosis by reducing macrophage proliferation but not polarization or apoptosis in lesions. PLoS One 8(8):e72674. [PubMed: 23991137]  [MGI Ref ID J:204917]

de Claro RA; Zhu X; Tang J; Morgan-Stevenson V; Schwartz BR; Iwata A; Liles WC; Raines EW; Harlan JM. 2011. Hematopoietic Fas Deficiency Does Not Affect Experimental Atherosclerotic Lesion Formation despite Inducing a Proatherogenic State. Am J Pathol 178(6):2931-7. [PubMed: 21550016]  [MGI Ref ID J:173162]

de Haan W; Out R; Berbee JF; van der Hoogt CC; van Dijk KW; van Berkel TJ; Romijn JA; Jukema JW; Havekes LM; Rensen PC. 2008. Apolipoprotein CI inhibits scavenger receptor BI and increases plasma HDL levels in vivo. Biochem Biophys Res Commun 377(4):1294-8. [PubMed: 18992221]  [MGI Ref ID J:143183]

de Nooijer R; Bot I; von der Thusen JH; Leeuwenburgh MA; Overkleeft HS; Kraaijeveld AO; Dorland R; van Santbrink PJ; van Heiningen SH; Westra MM; Kovanen PT; Jukema JW; van der Wall EE; van Berkel TJ; Shi GP; Biessen EA. 2009. Leukocyte cathepsin S is a potent regulator of both cell and matrix turnover in advanced atherosclerosis. Arterioscler Thromb Vasc Biol 29(2):188-94. [PubMed: 19095996]  [MGI Ref ID J:163799]

de Oliveira J; Hort MA; Moreira EL; Glaser V; Ribeiro-do-Valle RM; Prediger RD; Farina M; Latini A; de Bem AF. 2011. Positive correlation between elevated plasma cholesterol levels and cognitive impairments in LDL receptor knockout mice: relevance of cortico-cerebral mitochondrial dysfunction and oxidative stress. Neuroscience 197:99-106. [PubMed: 21945034]  [MGI Ref ID J:184047]

de Souza JC; de Oliveira CA; Carneiro EM; Boschero AC; de Oliveira HC. 2010. Cholesterol toxicity in pancreatic islets from LDL receptor-deficient mice. Diabetologia 53(11):2461-2; author reply 2463-4. [PubMed: 20694455]  [MGI Ref ID J:166652]

van Dijk KW; van Vlijmen BJ; de Winther MP; van 't Hof B; van der Zee A; van der Boom H; Havekes LM; Hofker MH. 1999. Hyperlipidemia of ApoE2(Arg(158)-Cys) and ApoE3-Leiden transgenic mice is modulated predominantly by LDL receptor expression. Arterioscler Thromb Vasc Biol 19(12):2945-51. [PubMed: 10591674]  [MGI Ref ID J:59826]

van Eck M; Bos IS; Kaminski WE; Orso E; Rothe G; Twisk J; Bottcher A; Van Amersfoort ES; Christiansen-Weber TA; Fung-Leung WP; Van Berkel TJ; Schmitz G. 2002. Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues. Proc Natl Acad Sci U S A 99(9):6298-303. [PubMed: 11972062]  [MGI Ref ID J:76337]

van Es T; van Puijvelde GH; Ramos OH; Segers FM; Joosten LA; van den Berg WB; Michon IM; de Vos P; van Berkel TJ; Kuiper J. 2009. Attenuated atherosclerosis upon IL-17R signaling disruption in LDLr deficient mice. Biochem Biophys Res Commun 388(2):261-5. [PubMed: 19660432]  [MGI Ref ID J:152718]

van Gils JM; Derby MC; Fernandes LR; Ramkhelawon B; Ray TD; Rayner KJ; Parathath S; Distel E; Feig JL; Alvarez-Leite JI; Rayner AJ; McDonald TO; O'Brien KD; Stuart LM; Fisher EA; Lacy-Hulbert A; Moore KJ. 2012. The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques. Nat Immunol 13(2):136-43. [PubMed: 22231519]  [MGI Ref ID J:181210]

van Kampen E; Jaminon A; van Berkel TJ; Van Eck M. 2014. Diet-induced (epigenetic) changes in bone marrow augment atherosclerosis. J Leukoc Biol 96(5):833-41. [PubMed: 25024399]  [MGI Ref ID J:220135]

van Leeuwen M; Kemna MJ; de Winther MP; Boon L; Duijvestijn AM; Henatsch D; Bos NA; Gijbels MJ; Tervaert JW. 2013. Passive immunization with hypochlorite-oxLDL specific antibodies reduces plaque volume in LDL receptor-deficient mice. PLoS One 8(7):e68039. [PubMed: 23874490]  [MGI Ref ID J:204410]

van Puijvelde GH; Hauer AD; de Vos P; van den Heuvel R; van Herwijnen MJ; van der Zee R; van Eden W; van Berkel TJ; Kuiper J. 2006. Induction of oral tolerance to oxidized low-density lipoprotein ameliorates atherosclerosis. Circulation 114(18):1968-76. [PubMed: 17060383]  [MGI Ref ID J:127201]

van Vlijmen BJ; Rohlmann A; Page ST; Bensadoun A; Bos IS; van Berkel TJ; Havekes LM; Herz J. 1999. An extrahepatic receptor-associated protein-sensitive mechanism is involved in the metabolism of triglyceride-rich lipoproteins. J Biol Chem 274(49):35219-26. [PubMed: 10575007]  [MGI Ref ID J:58704]

van Vlijmen BJ; van Dijk KW; van't Hof HB; van Gorp PJ; van der Zee A; van der Boom H; Breuer ML; Hofker MH; Havekes LM. 1996. In the absence of endogenous mouse apolipoprotein E, apolipoprotein E*2(Arg-158 --> Cys) transgenic mice develop more severe hyperlipoproteinemia than apolipoprotein E*3-Leiden transgenic mice. J Biol Chem 271(48):30595-602. [PubMed: 8940032]  [MGI Ref ID J:37473]

van der Hoogt CC; Berbee JF; Espirito Santo SM; Gerritsen G; Krom YD; van der Zee A; Havekes LM; van Dijk KW; Rensen PC. 2006. Apolipoprotein CI causes hypertriglyceridemia independent of the very-low-density lipoprotein receptor and apolipoprotein CIII in mice. Biochim Biophys Acta 1761(2):213-20. [PubMed: 16478678]  [MGI Ref ID J:110564]

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Bjorkegren J; Beigneux A; Bergo MO; Maher JJ; Young SG. 2002. Blocking the secretion of hepatic very low density lipoproteins renders the liver more susceptible to toxin-induced injury. J Biol Chem 277(7):5476-83. [PubMed: 11739387]  [MGI Ref ID J:74633]

Bjorkegren J; Veniant M; Kim SK; Withycombe SK; Wood PA; Hellerstein MK; Neese RA; Young SG. 2001. Lipoprotein secretion and triglyceride stores in the heart. J Biol Chem 276(42):38511-7. [PubMed: 11481337]  [MGI Ref ID J:120416]

Bjorkegren JL; Hagg S; Talukdar HA; Foroughi Asl H; Jain RK; Cedergren C; Shang MM; Rossignoli A; Takolander R; Melander O; Hamsten A; Michoel T; Skogsberg J. 2014. Plasma cholesterol-induced lesion networks activated before regression of early, mature, and advanced atherosclerosis. PLoS Genet 10(2):e1004201. [PubMed: 24586211]  [MGI Ref ID J:211003]

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Dikkers A; Annema W; de Boer JF; Iqbal J; Hussain MM; Tietge UJ. 2014. Differential impact of hepatic deficiency and total body inhibition of MTP on cholesterol metabolism and RCT in mice. J Lipid Res 55(5):816-25. [PubMed: 24511105]  [MGI Ref ID J:210163]

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Dougan SK; Rava P; Hussain MM; Blumberg RS. 2007. MTP regulated by an alternate promoter is essential for NKT cell development. J Exp Med 204(3):533-45. [PubMed: 17312007]  [MGI Ref ID J:125365]

Feig JE; Parathath S; Rong JX; Mick SL; Vengrenyuk Y; Grauer L; Young SG; Fisher EA. 2011. Reversal of hyperlipidemia with a genetic switch favorably affects the content and inflammatory state of macrophages in atherosclerotic plaques. Circulation 123(9):989-98. [PubMed: 21339485]  [MGI Ref ID J:183750]

Iqbal J; Rudel LL; Hussain MM. 2008. Microsomal triglyceride transfer protein enhances cellular cholesteryl esterification by relieving product inhibition. J Biol Chem 283(29):19967-80. [PubMed: 18502767]  [MGI Ref ID J:138737]

Khatun I; Zeissig S; Iqbal J; Wang M; Curiel D; Shelness GS; Blumberg RS; Hussain MM. 2012. Phospholipid transfer activity of microsomal triglyceride transfer protein produces apolipoprotein B and reduces hepatosteatosis while maintaining low plasma lipids in mice. Hepatology 55(5):1356-68. [PubMed: 22121032]  [MGI Ref ID J:210793]

Larsson SL; Skogsberg J; Bjorkegren J. 2004. The low density lipoprotein receptor prevents secretion of dense apoB100-containing lipoproteins from the liver. J Biol Chem 279(2):831-6. [PubMed: 14583618]  [MGI Ref ID J:124544]

Liao W; Hui TY; Young SG; Davis RA. 2003. Blocking microsomal triglyceride transfer protein interferes with apoB secretion without causing retention or stress in the ER. J Lipid Res 44(5):978-85. [PubMed: 12588952]  [MGI Ref ID J:83459]

Lieu HD; Withycombe SK; Walker Q; Rong JX; Walzem RL; Wong JS; Hamilton RL; Fisher EA; Young SG. 2003. Eliminating atherogenesis in mice by switching off hepatic lipoprotein secretion. Circulation 107(9):1315-21. [PubMed: 12628954]  [MGI Ref ID J:91722]

Miller JD; Chu Y; Castaneda LE; Serrano KM; Brooks RM; Heistad DD. 2013. Vascular function during prolonged progression and regression of atherosclerosis in mice. Arterioscler Thromb Vasc Biol 33(3):459-65. [PubMed: 23307875]  [MGI Ref ID J:216887]

Miller JD; Weiss RM; Serrano KM; Brooks RM 2nd; Berry CJ; Zimmerman K; Young SG; Heistad DD. 2009. Lowering plasma cholesterol levels halts progression of aortic valve disease in mice. Circulation 119(20):2693-701. [PubMed: 19433756]  [MGI Ref ID J:166428]

Miller JD; Weiss RM; Serrano KM; Castaneda LE; Brooks RM; Zimmerman K; Heistad DD. 2010. Evidence for active regulation of pro-osteogenic signaling in advanced aortic valve disease. Arterioscler Thromb Vasc Biol 30(12):2482-6. [PubMed: 20864669]  [MGI Ref ID J:183146]

Minehira K; Young SG; Villanueva CJ; Yetukuri L; Oresic M; Hellerstein MK; Farese RV Jr; Horton JD; Preitner F; Thorens B; Tappy L. 2008. Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice. J Lipid Res 49(9):2038-44. [PubMed: 18515909]  [MGI Ref ID J:139765]

Minehira-Castelli K; Leonard SW; Walker QM; Traber MG; Young SG. 2006. Absence of VLDL secretion does not affect alpha-tocopherol content in peripheral tissues. J Lipid Res 47(8):1733-8. [PubMed: 16710047]  [MGI Ref ID J:112587]

Olszak T; Neves JF; Dowds CM; Baker K; Glickman J; Davidson NO; Lin CS; Jobin C; Brand S; Sotlar K; Wada K; Katayama K; Nakajima A; Mizuguchi H; Kawasaki K; Nagata K; Muller W; Snapper SB; Schreiber S; Kaser A; Zeissig S; Blumberg RS. 2014. Protective mucosal immunity mediated by epithelial CD1d and IL-10. Nature 509(7501):497-502. [PubMed: 24717441]  [MGI Ref ID J:210436]

Parathath S; Grauer L; Huang LS; Sanson M; Distel E; Goldberg IJ; Fisher EA. 2011. Diabetes adversely affects macrophages during atherosclerotic plaque regression in mice. Diabetes 60(6):1759-69. [PubMed: 21562077]  [MGI Ref ID J:177946]

Raabe M; Veniant MM; Sullivan MA; Zlot CH; Bjorkegren J; Nielsen LB; Wong JS; Hamilton RL; Young SG. 1999. Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice. J Clin Invest 103(9):1287-98. [PubMed: 10225972]  [MGI Ref ID J:54612]

Ramsey SA; Vengrenyuk Y; Menon P; Podolsky I; Feig JE; Aderem A; Fisher EA; Gold ES. 2014. Epigenome-guided analysis of the transcriptome of plaque macrophages during atherosclerosis regression reveals activation of the Wnt signaling pathway. PLoS Genet 10(12):e1004828. [PubMed: 25474352]  [MGI Ref ID J:222183]

Sagiv Y; Bai L; Wei DG; Agami R; Savage PB; Teyton L; Bendelac A. 2007. A distal effect of microsomal triglyceride transfer protein deficiency on the lysosomal recycling of CD1d. J Exp Med 204(4):921-8. [PubMed: 17403933]  [MGI Ref ID J:125608]

Skogsberg J; Dicker A; Ryden M; Astrom G; Nilsson R; Bhuiyan H; Vitols S; Mairal A; Langin D; Alberts P; Walum E; Tegner J; Hamsten A; Arner P; Bjorkegren J. 2008. ApoB100-LDL acts as a metabolic signal from liver to peripheral fat causing inhibition of lipolysis in adipocytes. PLoS ONE 3(11):e3771. [PubMed: 19020660]  [MGI Ref ID J:143905]

Skogsberg J; Lundstrom J; Kovacs A; Nilsson R; Noori P; Maleki S; Kohler M; Hamsten A; Tegner J; Bjorkegren J. 2008. Transcriptional profiling uncovers a network of cholesterol-responsive atherosclerosis target genes. PLoS Genet 4(3):e1000036. [PubMed: 18369455]  [MGI Ref ID J:136835]

Xie Y; Fung HY; Newberry EP; Kennedy S; Luo J; Crooke RM; Graham MJ; Davidson NO. 2014. Hepatic Mttp deletion reverses gallstone susceptibility in L-Fabp knockout mice. J Lipid Res 55(3):540-8. [PubMed: 24474819]  [MGI Ref ID J:208783]

Xie Y; Luo J; Kennedy S; Davidson NO. 2007. Conditional intestinal lipotoxicity in Apobec-1-/- Mttp-IKO mice: a survival advantage for mammalian intestinal apolipoprotein BmRNA editing. J Biol Chem 282(45):33043-51. [PubMed: 17855359]  [MGI Ref ID J:126942]

Xie Y; Matsumoto H; Nalbantoglu I; Kerr TA; Luo J; Rubin DC; Kennedy S; Davidson NO. 2013. Intestine-Specific Mttp Deletion Increases the Severity of Experimental Colitis and Leads to Greater Tumor Burden in a Model of Colitis Associated Cancer. PLoS One 8(6):e67819. [PubMed: 23805328]  [MGI Ref ID J:204352]

Xie Y; Newberry EP; Young SG; Robine S; Hamilton RL; Wong JS; Luo J; Kennedy S; Davidson NO. 2006. Compensatory increase in hepatic lipogenesis in mice with conditional intestine-specific Mttp deficiency. J Biol Chem 281(7):4075-86. [PubMed: 16354657]  [MGI Ref ID J:108489]

Tg(Mx1-cre)1Cgn related

Abdel-Wahab O; Gao J; Adli M; Dey A; Trimarchi T; Chung YR; Kuscu C; Hricik T; Ndiaye-Lobry D; Lafave LM; Koche R; Shih AH; Guryanova OA; Kim E; Li S; Pandey S; Shin JY; Telis L; Liu J; Bhatt PK; Monette S; Zhao X; Mason CE; Park CY; Bernstein BE; Aifantis I; Levine RL. 2013. Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo. J Exp Med 210(12):2641-59. [PubMed: 24218140]  [MGI Ref ID J:208092]

Adelman CA; De S; Petrini JH. 2009. Rad50 is dispensable for the maintenance and viability of postmitotic tissues. Mol Cell Biol 29(2):483-92. [PubMed: 19001091]  [MGI Ref ID J:144766]

Akada H; Akada S; Hutchison RE; Mohi G. 2014. Loss of wild-type Jak2 allele enhances myeloid cell expansion and accelerates myelofibrosis in Jak2V617F knock-in mice. Leukemia 28(8):1627-35. [PubMed: 24480985]  [MGI Ref ID J:212503]

Akada H; Akada S; Hutchison RE; Sakamoto K; Wagner KU; Mohi G. 2014. Critical role of Jak2 in the maintenance and function of adult hematopoietic stem cells. Stem Cells 32(7):1878-89. [PubMed: 24677703]  [MGI Ref ID J:216787]

Akada H; Yan D; Zou H; Fiering S; Hutchison RE; Mohi MG. 2010. Conditional expression of heterozygous or homozygous Jak2V617F from its endogenous promoter induces a polycythemia vera-like disease. Blood 115(17):3589-97. [PubMed: 20197548]  [MGI Ref ID J:184283]

Akbar H; Shang X; Perveen R; Berryman M; Funk K; Johnson JF; Tandon NN; Zheng Y. 2011. Gene Targeting Implicates Cdc42 GTPase in GPVI and Non-GPVI Mediated Platelet Filopodia Formation, Secretion and Aggregation. PLoS One 6(7):e22117. [PubMed: 21789221]  [MGI Ref ID J:174929]

Akerman ME; Pilch J; Peters D; Ruoslahti E. 2005. Angiostatic peptides use plasma fibronectin to home to angiogenic vasculature. Proc Natl Acad Sci U S A 102(6):2040-5. [PubMed: 15687502]  [MGI Ref ID J:96503]

Akiyama TE; Sakai S; Lambert G; Nicol CJ; Matsusue K; Pimprale S; Lee YH; Ricote M; Glass CK; Brewer HB Jr; Gonzalez FJ. 2002. Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux. Mol Cell Biol 22(8):2607-19. [PubMed: 11909955]  [MGI Ref ID J:75777]

Alexaki A; Gupta SD; Majumder S; Kono M; Tuymetova G; Harmon JM; Dunn TM; Proia RL. 2014. Autophagy regulates sphingolipid levels in the liver. J Lipid Res 55(12):2521-31. [PubMed: 25332431]  [MGI Ref ID J:217156]

Aliprantis AO; Stolina M; Kostenuik PJ; Poliachik SL; Warner SE; Bain SD; Gross TS. 2012. Transient muscle paralysis degrades bone via rapid osteoclastogenesis. FASEB J 26(3):1110-8. [PubMed: 22125315]  [MGI Ref ID J:182803]

Aliprantis AO; Ueki Y; Sulyanto R; Park A; Sigrist KS; Sharma SM; Ostrowski MC; Olsen BR; Glimcher LH. 2008. NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism. J Clin Invest 118(11):3775-89. [PubMed: 18846253]  [MGI Ref ID J:144598]

Allende ML; Zhou D; Kalkofen DN; Benhamed S; Tuymetova G; Borowski C; Bendelac A; Proia RL. 2008. S1P1 receptor expression regulates emergence of NKT cells in peripheral tissues. FASEB J 22(1):307-15. [PubMed: 17785606]  [MGI Ref ID J:134801]

Alonzi T; Maritano D; Gorgoni B; Rizzuto G; Libert C; Poli V. 2001. Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene activation in the liver. Mol Cell Biol 21(5):1621-32. [PubMed: 11238899]  [MGI Ref ID J:67357]

Alonzi T; Newton IP; Bryce PJ; Di Carlo E; Lattanzio G; Tripodi M; Musiani P; Poli V. 2004. Induced somatic inactivation of STAT3 in mice triggers the development of a fulminant form of enterocolitis. Cytokine 26(2):45-56. [PubMed: 15050604]  [MGI Ref ID J:146716]

Ambrogini E; Almeida M; Martin-Millan M; Paik JH; Depinho RA; Han L; Goellner J; Weinstein RS; Jilka RL; O'Brien CA; Manolagas SC. 2010. FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice. Cell Metab 11(2):136-46. [PubMed: 20142101]  [MGI Ref ID J:158622]

Ammirante M; Luo JL; Grivennikov S; Nedospasov S; Karin M. 2010. B-cell-derived lymphotoxin promotes castration-resistant prostate cancer. Nature 464(7286):302-5. [PubMed: 20220849]  [MGI Ref ID J:157973]

Anwar K; Iqbal J; Hussain MM. 2007. Mechanisms involved in vitamin E transport by primary enterocytes and in vivo absorption. J Lipid Res 48(9):2028-38. [PubMed: 17582142]  [MGI Ref ID J:125237]

Araya R; Eckardt D; Maxeiner S; Kruger O; Theis M; Willecke K; Saez JC. 2005. Expression of connexins during differentiation and regeneration of skeletal muscle: functional relevance of connexin43. J Cell Sci 118(Pt 1):27-37. [PubMed: 15601660]  [MGI Ref ID J:94694]

Arieta Kuksin C; Gonzalez-Perez G; Minter LM. 2015. CXCR4 expression on pathogenic T cells facilitates their bone marrow infiltration in a mouse model of aplastic anemia. Blood 125(13):2087-94. [PubMed: 25647836]  [MGI Ref ID J:222051]

Arnon TI; Xu Y; Lo C; Pham T; An J; Coughlin S; Dorn GW; Cyster JG. 2011. GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood. Science 333(6051):1898-903. [PubMed: 21960637]  [MGI Ref ID J:176118]

Artinger EL; Mishra BP; Zaffuto KM; Li BE; Chung EK; Moore AW; Chen Y; Cheng C; Ernst P. 2013. An MLL-dependent network sustains hematopoiesis. Proc Natl Acad Sci U S A 110(29):12000-5. [PubMed: 23744037]  [MGI Ref ID J:198726]

Assi H; Espinosa J; Suprise S; Sofroniew M; Doherty R; Zamler D; Lowenstein PR; Castro MG. 2014. Assessing the role of STAT3 in DC differentiation and autologous DC immunotherapy in mouse models of GBM. PLoS One 9(5):e96318. [PubMed: 24806510]  [MGI Ref ID J:217363]

Avagyan S; Aguilo F; Kamezaki K; Snoeck HW. 2011. Quantitative trait mapping reveals a regulatory axis involving peroxisome proliferator-activated receptors, PRDM16, transforming growth factor-beta2 and FLT3 in hematopoiesis. Blood 118(23):6078-86. [PubMed: 21967974]  [MGI Ref ID J:179097]

Baena E; Gandarillas A; Vallespinos M; Zanet J; Bachs O; Redondo C; Fabregat I; Martinez-A C; de Alboran IM. 2005. c-Myc regulates cell size and ploidy but is not essential for postnatal proliferation in liver. Proc Natl Acad Sci U S A 102(20):7286-91. [PubMed: 15857952]  [MGI Ref ID J:99242]

Baena E; Ortiz M; Martinez-A C; de Alboran IM. 2007. c-Myc is essential for hematopoietic stem cell differentiation and regulates Lin(-)Sca-1(+)c-Kit(-) cell generation through p21. Exp Hematol 35(9):1333-43. [PubMed: 17637497]  [MGI Ref ID J:126563]

Baker SJ; Ma'ayan A; Lieu YK; John P; Reddy MV; Chen EY; Duan Q; Snoeck HW; Reddy EP. 2014. B-myb is an essential regulator of hematopoietic stem cell and myeloid progenitor cell development. Proc Natl Acad Sci U S A 111(8):3122-7. [PubMed: 24516162]  [MGI Ref ID J:206816]

Banerjee ER; Jiang Y; Henderson WR Jr; Latchman Y; Papayannopoulou T. 2009. Absence of alpha 4 but not beta 2 integrins restrains development of chronic allergic asthma using mouse genetic models. Exp Hematol 37(6):715-727.e3. [PubMed: 19463772]  [MGI Ref ID J:151240]

Banerjee ER; Jiang Y; Henderson WR Jr; Scott LM; Papayannopoulou T. 2007. Alpha4 and beta2 integrins have nonredundant roles for asthma development, but for optimal allergen sensitization only alpha4 is critical. Exp Hematol 35(4):605-17. [PubMed: 17379071]  [MGI Ref ID J:123141]

Banerjee ER; Latchman YE; Jiang Y; Priestley GV; Papayannopoulou T. 2008. Distinct changes in adult lymphopoiesis in Rag2-/- mice fully reconstituted by alpha4-deficient adult bone marrow cells. Exp Hematol 36(8):1004-13. [PubMed: 18468770]  [MGI Ref ID J:139405]

Barde I; Rauwel B; Marin-Florez RM; Corsinotti A; Laurenti E; Verp S; Offner S; Marquis J; Kapopoulou A; Vanicek J; Trono D. 2013. A KRAB/KAP1-miRNA cascade regulates erythropoiesis through stage-specific control of mitophagy. Science 340(6130):350-3. [PubMed: 23493425]  [MGI Ref ID J:195118]

Bauer M; Brakebusch C; Coisne C; Sixt M; Wekerle H; Engelhardt B; Fassler R. 2009. Beta1 integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity. Proc Natl Acad Sci U S A 106(6):1920-5. [PubMed: 19179279]  [MGI Ref ID J:144959]

Behrens A; Sibilia M; David JP; Mohle-Steinlein U; Tronche F; Schutz G; Wagner EF. 2002. Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c-jun in the liver. EMBO J 21(7):1782-90. [PubMed: 11927562]  [MGI Ref ID J:75863]

Beier F; Foronda M; Martinez P; Blasco MA. 2012. Conditional TRF1 knockout in the hematopoietic compartment leads to bone marrow failure and recapitulates clinical features of dyskeratosis congenita. Blood 120(15):2990-3000. [PubMed: 22932806]  [MGI Ref ID J:192926]

Bejar R; Lord A; Stevenson K; Bar-Natan M; Perez-Ladaga A; Zaneveld J; Wang H; Caughey B; Stojanov P; Getz G; Garcia-Manero G; Kantarjian H; Chen R; Stone RM; Neuberg D; Steensma DP; Ebert BL. 2014. TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients. Blood 124(17):2705-12. [PubMed: 25224413]  [MGI Ref ID J:218683]

Benhamouche S; Curto M; Saotome I; Gladden AB; Liu CH; Giovannini M; McClatchey AI. 2010. Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver. Genes Dev 24(16):1718-30. [PubMed: 20675406]  [MGI Ref ID J:163257]

Bentmann A; Kawelke N; Moss D; Zentgraf H; Bala Y; Berger I; Gasser JA; Nakchbandi IA. 2010. Circulating fibronectin affects bone matrix, whereas osteoblast fibronectin modulates osteoblast function. J Bone Miner Res 25(4):706-15. [PubMed: 19821765]  [MGI Ref ID J:179869]

Benz C; Martins VC; Radtke F; Bleul CC. 2008. The stream of precursors that colonizes the thymus proceeds selectively through the early T lineage precursor stage of T cell development. J Exp Med 205(5):1187-99. [PubMed: 18458114]  [MGI Ref ID J:136220]

Berberich S; Dahne S; Schippers A; Peters T; Muller W; Kremmer E; Forster R; Pabst O. 2008. Differential molecular and anatomical basis for B cell migration into the peritoneal cavity and omental milky spots. J Immunol 180(4):2196-203. [PubMed: 18250426]  [MGI Ref ID J:132002]

Bereshchenko O; Mancini E; Luciani L; Gambardella A; Riccardi C; Nerlov C. 2012. Pontin is essential for murine hematopoietic stem cell survival. Haematologica 97(9):1291-4. [PubMed: 22371176]  [MGI Ref ID J:220926]

Berger A; Hoelbl-Kovacic A; Bourgeais J; Hoefling L; Warsch W; Grundschober E; Uras IZ; Menzl I; Putz EM; Hoermann G; Schuster C; Fajmann S; Leitner E; Kubicek S; Moriggl R; Gouilleux F; Sexl V. 2014. PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis. Leukemia 28(3):629-41. [PubMed: 24263804]  [MGI Ref ID J:206976]

Bergo MO; Lieu HD; Gavino BJ; Ambroziak P; Otto JC; Casey PJ; Walker QM; Young SG. 2004. On the physiological importance of endoproteolysis of CAAX proteins: heart-specific RCE1 knockout mice develop a lethal cardiomyopathy. J Biol Chem 279(6):4729-36. [PubMed: 14625273]  [MGI Ref ID J:87958]

Besseyrias V; Fiorini E; Strobl LJ; Zimber-Strobl U; Dumortier A; Koch U; Arcangeli ML; Ezine S; Macdonald HR; Radtke F. 2007. Hierarchy of Notch-Delta interactions promoting T cell lineage commitment and maturation. J Exp Med 204(2):331-43. [PubMed: 17261636]  [MGI Ref ID J:125373]

Betz UA; Bloch W; van den Broek M; Yoshida K; Taga T; Kishimoto T; Addicks K; Rajewsky K; Muller W. 1998. Postnatally induced inactivation of gp130 in mice results in neurological, cardiac, hematopoietic, immunological, hepatic, and pulmonary defects. J Exp Med 188(10):1955-65. [PubMed: 9815272]  [MGI Ref ID J:67677]

Bjorkegren JL; Hagg S; Talukdar HA; Foroughi Asl H; Jain RK; Cedergren C; Shang MM; Rossignoli A; Takolander R; Melander O; Hamsten A; Michoel T; Skogsberg J. 2014. Plasma cholesterol-induced lesion networks activated before regression of early, mature, and advanced atherosclerosis. PLoS Genet 10(2):e1004201. [PubMed: 24586211]  [MGI Ref ID J:211003]

Bleuming SA; He XC; Kodach LL; Hardwick JC; Koopman FA; Ten Kate FJ; van Deventer SJ; Hommes DW; Peppelenbosch MP; Offerhaus GJ; Li L; van den Brink GR. 2007. Bone morphogenetic protein signaling suppresses tumorigenesis at gastric epithelial transition zones in mice. Cancer Res 67(17):8149-55. [PubMed: 17804727]  [MGI Ref ID J:124881]

Bohm C; Hayer S; Kilian A; Zaiss MM; Finger S; Hess A; Engelke K; Kollias G; Kronke G; Zwerina J; Schett G; David JP. 2009. The alpha-isoform of p38 MAPK specifically regulates arthritic bone loss. J Immunol 183(9):5938-47. [PubMed: 19828631]  [MGI Ref ID J:156807]

Bondar T; Medzhitov R. 2010. p53-mediated hematopoietic stem and progenitor cell competition. Cell Stem Cell 6(4):309-22. [PubMed: 20362536]  [MGI Ref ID J:158953]

Borowiak M; Garratt AN; Wustefeld T; Strehle M; Trautwein C; Birchmeier C. 2004. Met provides essential signals for liver regeneration. Proc Natl Acad Sci U S A 101(29):10608-13. [PubMed: 15249655]  [MGI Ref ID J:91484]

Bourgeois C; Hao Z; Rajewsky K; Potocnik AJ; Stockinger B. 2008. Ablation of thymic export causes accelerated decay of naive CD4 T cells in the periphery because of activation by environmental antigen. Proc Natl Acad Sci U S A 105(25):8691-6. [PubMed: 18562288]  [MGI Ref ID J:143955]

Brakebusch C; Fillatreau S; Potocnik AJ; Bungartz G; Wilhelm P; Svensson M; Kearney P; Korner H; Gray D; Fassler R. 2002. Beta1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response. Immunity 16(3):465-77. [PubMed: 11911830]  [MGI Ref ID J:75623]

Braun BS; Archard JA; Van Ziffle JA; Tuveson DA; Jacks TE; Shannon K. 2006. Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo. Blood 108(6):2041-4. [PubMed: 16720837]  [MGI Ref ID J:115071]

Braun BS; Tuveson DA; Kong N; Le DT; Kogan SC; Rozmus J; Le Beau MM; Jacks TE; Shannon KM. 2004. Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder. Proc Natl Acad Sci U S A 101(2):597-602. [PubMed: 14699048]  [MGI Ref ID J:87429]

Breart B; Ramos-Perez WD; Mendoza A; Salous AK; Gobert M; Huang Y; Adams RH; Lafaille JJ; Escalante-Alcalde D; Morris AJ; Schwab SR. 2011. Lipid phosphate phosphatase 3 enables efficient thymic egress. J Exp Med 208(6):1267-78. [PubMed: 21576386]  [MGI Ref ID J:176831]

Brooks R; Fuhler GM; Iyer S; Smith MJ; Park MY; Paraiso KH; Engelman RW; Kerr WG. 2010. SHIP1 inhibition increases immunoregulatory capacity and triggers apoptosis of hematopoietic cancer cells. J Immunol 184(7):3582-9. [PubMed: 20200281]  [MGI Ref ID J:160073]

Broske AM; Vockentanz L; Kharazi S; Huska MR; Mancini E; Scheller M; Kuhl C; Enns A; Prinz M; Jaenisch R; Nerlov C; Leutz A; Andrade-Navarro MA; Jacobsen SE; Rosenbauer F. 2009. DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction. Nat Genet 41(11):1207-15. [PubMed: 19801979]  [MGI Ref ID J:155126]

Bungartz G; Land H; Scadden DT; Emerson SG. 2012. NF-Y is necessary for hematopoietic stem cell proliferation and survival. Blood 119(6):1380-9. [PubMed: 22072554]  [MGI Ref ID J:181647]

Buonamici S; Trimarchi T; Ruocco MG; Reavie L; Cathelin S; Mar BG; Klinakis A; Lukyanov Y; Tseng JC; Sen F; Gehrie E; Li M; Newcomb E; Zavadil J; Meruelo D; Lipp M; Ibrahim S; Efstratiadis A; Zagzag D; Bromberg JS; Dustin ML; Aifantis I. 2009. CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia. Nature 459(7249):1000-4. [PubMed: 19536265]  [MGI Ref ID J:197167]

Burgess MR; Hwang E; Firestone AJ; Huang T; Xu J; Zuber J; Bohin N; Wen T; Kogan SC; Haigis KM; Sampath D; Lowe S; Shannon K; Li Q. 2014. Preclinical efficacy of MEK inhibition in Nras-mutant AML. Blood 124(26):3947-55. [PubMed: 25361812]  [MGI Ref ID J:220778]

Buza-Vidas N; Cismasiu VB; Moore S; Mead AJ; Woll PS; Lutteropp M; Melchiori L; Luc S; Bouriez-Jones T; Atkinson D; O'Carroll D; Jacobsen SE; Nerlov C. 2012. Dicer is selectively important for the earliest stages of erythroid development. Blood 120(12):2412-6. [PubMed: 22869792]  [MGI Ref ID J:191447]

Byon JC; Chen J; Doty RT; Abkowitz JL. 2013. FLVCR is necessary for erythroid maturation, may contribute to platelet maturation, but is dispensable for normal hematopoietic stem cell function. Blood 122(16):2903-10. [PubMed: 24021674]  [MGI Ref ID J:204083]

Cai X; Gaudet JJ; Mangan JK; Chen MJ; De Obaldia ME; Oo Z; Ernst P; Speck NA. 2011. Runx1 loss minimally impacts long-term hematopoietic stem cells. PLoS One 6(12):e28430. [PubMed: 22145044]  [MGI Ref ID J:182271]

Cales C; Roman-Trufero M; Pavon L; Serrano I; Melgar T; Endoh M; Perez C; Koseki H; Vidal M. 2008. Inactivation of the polycomb group protein Ring1B unveils an antiproliferative role in hematopoietic cell expansion and cooperation with tumorigenesis associated with Ink4a deletion. Mol Cell Biol 28(3):1018-28. [PubMed: 18039844]  [MGI Ref ID J:130397]

Camerer E; Regard JB; Cornelissen I; Srinivasan Y; Duong DN; Palmer D; Pham TH; Wong JS; Pappu R; Coughlin SR. 2009. Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice. J Clin Invest 119(7):1871-9. [PubMed: 19603543]  [MGI Ref ID J:152547]

Cancelas JA; Jansen M; Williams DA. 2006. The role of chemokine activation of Rac GTPases in hematopoietic stem cell marrow homing, retention, and peripheral mobilization. Exp Hematol 34(8):976-85. [PubMed: 16863904]  [MGI Ref ID J:111908]

Carofino BL; Ayanga B; Justice MJ. 2013. A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL). Dis Model Mech 6(6):1494-506. [PubMed: 24046360]  [MGI Ref ID J:202090]

Carotta S; Dakic A; D'Amico A; Pang SH; Greig KT; Nutt SL; Wu L. 2010. The transcription factor PU.1 controls dendritic cell development and Flt3 cytokine receptor expression in a dose-dependent manner. Immunity 32(5):628-41. [PubMed: 20510871]  [MGI Ref ID J:160816]

Caton ML; Smith-Raska MR; Reizis B. 2007. Notch-RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleen. J Exp Med 204(7):1653-64. [PubMed: 17591855]  [MGI Ref ID J:125869]

Challen GA; Sun D; Jeong M; Luo M; Jelinek J; Berg JS; Bock C; Vasanthakumar A; Gu H; Xi Y; Liang S; Lu Y; Darlington GJ; Meissner A; Issa JP; Godley LA; Li W; Goodell MA. 2011. Dnmt3a is essential for hematopoietic stem cell differentiation. Nat Genet 44(1):23-31. [PubMed: 22138693]  [MGI Ref ID J:179661]

Chan CK; Seo EY; Chen JY; Lo D; McArdle A; Sinha R; Tevlin R; Seita J; Vincent-Tompkins J; Wearda T; Lu WJ; Senarath-Yapa K; Chung MT; Marecic O; Tran M; Yan KS; Upton R; Walmsley GG; Lee AS; Sahoo D; Kuo CJ; Weissman IL; Longaker MT. 2015. Identification and specification of the mouse skeletal stem cell. Cell 160(1-2):285-98. [PubMed: 25594184]  [MGI Ref ID J:219579]

Chan G; Cheung LS; Yang W; Milyavsky M; Sanders AD; Gu S; Hong WX; Liu AX; Wang X; Barbara M; Sharma T; Gavin J; Kutok JL; Iscove NN; Shannon KM; Dick JE; Neel BG; Braun BS. 2011. Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells. Blood 117(16):4253-61. [PubMed: 21398220]  [MGI Ref ID J:173832]

Chan G; Gu S; Neel BG. 2013. Erk1 and Erk2 are required for maintenance of hematopoietic stem cells and adult hematopoiesis. Blood 121(18):3594-8. [PubMed: 23444405]  [MGI Ref ID J:197571]

Chan G; Kalaitzidis D; Usenko T; Kutok JL; Yang W; Mohi MG; Neel BG. 2009. Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis. Blood 113(18):4414-24. [PubMed: 19179468]  [MGI Ref ID J:148430]

Chan IT; Kutok JL; Williams IR; Cohen S; Kelly L; Shigematsu H; Johnson L; Akashi K; Tuveson DA; Jacks T; Gilliland DG. 2004. Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease. J Clin Invest 113(4):528-38. [PubMed: 14966562]  [MGI Ref ID J:88163]

Chan IT; Kutok JL; Williams IR; Cohen S; Moore S; Shigematsu H; Ley TJ; Akashi K; Le Beau MM; Gilliland DG. 2006. Oncogenic K-ras cooperates with PML-RAR alpha to induce an acute promyelocytic leukemia-like disease. Blood 108(5):1708-15. [PubMed: 16675706]  [MGI Ref ID J:115068]

Chan WI; Hannah RL; Dawson MA; Pridans C; Foster D; Joshi A; Gottgens B; Van Deursen JM; Huntly BJ. 2011. The transcriptional coactivator cbp regulates self-renewal and differentiation in adult hematopoietic stem cells. Mol Cell Biol 31(24):5046-60. [PubMed: 22006020]  [MGI Ref ID J:178304]

Chang T; Krisman K; Theobald EH; Xu J; Akutagawa J; Lauchle JO; Kogan S; Braun BS; Shannon K. 2013. Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice. J Clin Invest 123(1):335-9. [PubMed: 23221337]  [MGI Ref ID J:194161]

Charles JF; Coury F; Sulyanto R; Sitara D; Wu J; Brady N; Tsang K; Sigrist K; Tollefsen DM; He L; Storm D; Aliprantis AO. 2012. The collection of NFATc1-dependent transcripts in the osteoclast includes numerous genes non-essential to physiologic bone resorption. Bone 51(5):902-12. [PubMed: 22985540]  [MGI Ref ID J:193573]

Chatterjee A; Ghosh J; Ramdas B; Mali RS; Martin H; Kobayashi M; Vemula S; Canela VH; Waskow ER; Visconte V; Tiu RV; Smith CC; Shah N; Bunting KD; Boswell HS; Liu Y; Chan RJ; Kapur R. 2014. Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis. Cell Rep 9(4):1333-48. [PubMed: 25456130]  [MGI Ref ID J:218754]

Chee LC; Hendy J; Purton LE; McArthur GA. 2013. ATRA and the specific RARalpha agonist, NRX195183, have opposing effects on the clonogenicity of pre-leukemic murine AML1-ETO bone marrow cells. Leukemia 27(6):1369-80. [PubMed: 23228968]  [MGI Ref ID J:198248]

Chee LC; Hendy J; Purton LE; McArthur GA. 2013. The granulocyte-colony stimulating factor receptor (G-CSFR) interacts with retinoic acid receptors (RARs) in the regulation of myeloid differentiation. J Leukoc Biol 93(2):235-43. [PubMed: 23136256]  [MGI Ref ID J:193750]

Chen C; Liu Y; Liu R; Ikenoue T; Guan KL; Liu Y; Zheng P. 2008. TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. J Exp Med 205(10):2397-408. [PubMed: 18809716]  [MGI Ref ID J:140099]

Chen H; Zou Z; Sarratt KL; Zhou D; Zhang M; Sebzda E; Hammer DA; Kahn ML. 2006. In vivo beta1 integrin function requires phosphorylation-independent regulation by cytoplasmic tyrosines. Genes Dev 20(8):927-32. [PubMed: 16618804]  [MGI Ref ID J:108331]

Chen HZ; Ouseph MM; Li J; Pecot T; Chokshi V; Kent L; Bae S; Byrne M; Duran C; Comstock G; Trikha P; Mair M; Senapati S; Martin CK; Gandhi S; Wilson N; Liu B; Huang YW; Thompson JC; Raman S; Singh S; Leone M; Machiraju R; Huang K; Mo X; Fernandez S; Kalaszczynska I; Wolgemuth DJ; Sicinski P; Huang T; Jin V; Leone G. 2012. Canonical and atypical E2Fs regulate the mammalian endocycle. Nat Cell Biol 14(11):1192-202. [PubMed: 23064266]  [MGI Ref ID J:190713]

Chen W; Han C; Xie B; Hu X; Yu Q; Shi L; Wang Q; Li D; Wang J; Zheng P; Liu Y; Cao X. 2013. Induction of Siglec-G by RNA Viruses Inhibits the Innate Immune Response by Promoting RIG-I Degradation. Cell 152(3):467-78. [PubMed: 23374343]  [MGI Ref ID J:193456]

Chen X; Barozzi I; Termanini A; Prosperini E; Recchiuti A; Dalli J; Mietton F; Matteoli G; Hiebert S; Natoli G. 2012. Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophages. Proc Natl Acad Sci U S A 109(42):E2865-74. [PubMed: 22802645]  [MGI Ref ID J:188513]

Cheng M; Zhou J; Wu M; Boriboun C; Thorne T; Liu T; Xiang Z; Zeng Q; Tanaka T; Tang YL; Kishore R; Tomasson MH; Miller RJ; Losordo DW; Qin G. 2010. CXCR4-mediated bone marrow progenitor cell maintenance and mobilization are modulated by c-kit activity. Circ Res 107(9):1083-93. [PubMed: 20847314]  [MGI Ref ID J:178186]

Chiang MY; Shestova O; Xu L; Aster JC; Pear WS. 2013. Divergent effects of supraphysiologic Notch signals on leukemia stem cells and hematopoietic stem cells. Blood 121(6):905-17. [PubMed: 23115273]  [MGI Ref ID J:194558]

Chinenov Y; Gupte R; Dobrovolna J; Flammer JR; Liu B; Michelassi FE; Rogatsky I. 2012. Role of transcriptional coregulator GRIP1 in the anti-inflammatory actions of glucocorticoids. Proc Natl Acad Sci U S A 109(29):11776-81. [PubMed: 22753499]  [MGI Ref ID J:186491]

Choi J; Ko M; Jeon S; Jeon Y; Park K; Lee C; Lee H; Seong RH. 2012. The SWI/SNF-like BAF complex is essential for early B cell development. J Immunol 188(8):3791-803. [PubMed: 22427636]  [MGI Ref ID J:184060]

Choi YJ; Li X; Hydbring P; Sanda T; Stefano J; Christie AL; Signoretti S; Look AT; Kung AL; von Boehmer H; Sicinski P. 2012. The requirement for cyclin D function in tumor maintenance. Cancer Cell 22(4):438-51. [PubMed: 23079655]  [MGI Ref ID J:192032]

Choi YJ; Saez B; Anders L; Hydbring P; Stefano J; Bacon NA; Cook C; Kalaszczynska I; Signoretti S; Young RA; Scadden DT; Sicinski P. 2014. D-cyclins repress apoptosis in hematopoietic cells by controlling death receptor Fas and its ligand FasL. Dev Cell 30(3):255-67. [PubMed: 25087893]  [MGI Ref ID J:214085]

Chou WC; Levy DE; Lee CK. 2006. STAT3 positively regulates an early step in B-cell development. Blood 108(9):3005-11. [PubMed: 16825489]  [MGI Ref ID J:140460]

Cobas M; Wilson A; Ernst B; Mancini SJ; MacDonald HR; Kemler R; Radtke F. 2004. Beta-catenin is dispensable for hematopoiesis and lymphopoiesis. J Exp Med 199(2):221-9. [PubMed: 14718516]  [MGI Ref ID J:89995]

Collazo MM; Paraiso KH; Park MY; Hazen AL; Kerr WG. 2012. Lineage extrinsic and intrinsic control of immunoregulatory cell numbers by SHIP. Eur J Immunol 42(7):1785-95. [PubMed: 22535653]  [MGI Ref ID J:187777]

Collazo MM; Wood D; Paraiso KH; Lund E; Engelman RW; Le CT; Stauch D; Kotsch K; Kerr WG. 2009. SHIP limits immunoregulatory capacity in the T-cell compartment. Blood 113(13):2934-44. [PubMed: 19136659]  [MGI Ref ID J:146908]

Coury F; Zenger S; Stewart AK; Stephens S; Neff L; Tsang K; Shull GE; Alper SL; Baron R; Aliprantis AO. 2013. SLC4A2-mediated Cl-/HCO3- exchange activity is essential for calpain-dependent regulation of the actin cytoskeleton in osteoclasts. Proc Natl Acad Sci U S A 110(6):2163-8. [PubMed: 23341620]  [MGI Ref ID J:193823]

Cunningham K; Uchida Y; O'Donnell E; Claudio E; Li W; Soneji K; Wang H; Mukouyama YS; Siebenlist U. 2011. Conditional deletion of Ccm2 causes hemorrhage in the adult brain: a mouse model of human cerebral cavernous malformations. Hum Mol Genet 20(16):3198-206. [PubMed: 21596842]  [MGI Ref ID J:174085]

Cunningham L; Finckbeiner S; Hyde RK; Southall N; Marugan J; Yedavalli VR; Dehdashti SJ; Reinhold WC; Alemu L; Zhao L; Yeh JR; Sood R; Pommier Y; Austin CP; Jeang KT; Zheng W; Liu P. 2012. Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFbeta interaction. Proc Natl Acad Sci U S A 109(36):14592-7. [PubMed: 22912405]  [MGI Ref ID J:189877]

Curtis DJ; Hall MA; Van Stekelenburg LJ; Robb L; Jane SM; Begley CG. 2004. SCL is required for normal function of short-term repopulating hematopoietic stem cells. Blood 103(9):3342-8. [PubMed: 14726374]  [MGI Ref ID J:90290]

Cutts BA; Sjogren AK; Andersson KM; Wahlstrom AM; Karlsson C; Swolin B; Bergo MO. 2009. Nf1 deficiency cooperates with oncogenic K-RAS to induce acute myeloid leukemia in mice. Blood 114(17):3629-32. [PubMed: 19710506]  [MGI Ref ID J:153839]

Dakic A; Metcalf D; Di Rago L; Mifsud S; Wu L; Nutt SL. 2005. PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis. J Exp Med 201(9):1487-502. [PubMed: 15867096]  [MGI Ref ID J:98188]

Darshan D; Vanoaica L; Richman L; Beermann F; Kuhn LC. 2009. Conditional deletion of ferritin H in mice induces loss of iron storage and liver damage. Hepatology 50(3):852-60. [PubMed: 19492434]  [MGI Ref ID J:166515]

Das M; Garlick DS; Greiner DL; Davis RJ. 2011. The role of JNK in the development of hepatocellular carcinoma. Genes Dev 25(6):634-45. [PubMed: 21406557]  [MGI Ref ID J:171040]

Das M; Sabio G; Jiang F; Rincon M; Flavell RA; Davis RJ. 2009. Induction of hepatitis by JNK-mediated expression of TNF-alpha. Cell 136(2):249-60. [PubMed: 19167327]  [MGI Ref ID J:147632]

De Vita S; Schneider RK; Garcia M; Wood J; Gavillet M; Ebert BL; Gerbaulet A; Roers A; Levine RL; Mullally A; Williams DA. 2014. Loss of function of TET2 cooperates with constitutively active KIT in murine and human models of mastocytosis. PLoS One 9(5):e96209. [PubMed: 24788138]  [MGI Ref ID J:217231]

Deckert M; Lutjen S; Leuker CE; Kwok LY; Strack A; Muller W; Wagner N; Schluter D. 2003. Mice with neonatally induced inactivation of the vascular cell adhesion molecule-1 fail to control the parasite in Toxoplasma encephalitis. Eur J Immunol 33(5):1418-28. [PubMed: 12731069]  [MGI Ref ID J:83353]

Demuth I; Frappart PO; Hildebrand G; Melchers A; Lobitz S; Stockl L; Varon R; Herceg Z; Sperling K; Wang ZQ; Digweed M. 2004. An inducible null mutant murine model of Nijmegen breakage syndrome proves the essential function of NBS1 in chromosomal stability and cell viability. Hum Mol Genet 13(20):2385-97. [PubMed: 15333589]  [MGI Ref ID J:93598]

Deng J; Liu Y; Lee H; Herrmann A; Zhang W; Zhang C; Shen S; Priceman SJ; Kujawski M; Pal SK; Raubitschek A; Hoon DS; Forman S; Figlin RA; Liu J; Jove R; Yu H. 2012. S1PR1-STAT3 signaling is crucial for myeloid cell colonization at future metastatic sites. Cancer Cell 21(5):642-54. [PubMed: 22624714]  [MGI Ref ID J:189298]

Dishowitz MI; Mutyaba PL; Takacs JD; Barr AM; Engiles JB; Ahn J; Hankenson KD. 2013. Systemic inhibition of canonical Notch signaling results in sustained callus inflammation and alters multiple phases of fracture healing. PLoS One 8(7):e68726. [PubMed: 23844237]  [MGI Ref ID J:204295]

Dooher JE; Paz-Priel I; Houng S; Baldwin AS Jr; Friedman AD. 2011. C/EBPalpha, C/EBPalpha oncoproteins, or C/EBPbeta preferentially bind NF-kappaB p50 compared with p65, focusing therapeutic targeting on the C/EBP:p50 interaction. Mol Cancer Res 9(10):1395-405. [PubMed: 21813505]  [MGI Ref ID J:205221]

Dos Santos C; McDonald T; Ho YW; Liu H; Lin A; Forman SJ; Kuo YH; Bhatia R. 2013. The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agents. Blood 122(11):1900-13. [PubMed: 23896410]  [MGI Ref ID J:202360]

Du J; Chen Y; Li Q; Han X; Cheng C; Wang Z; Danielpour D; Dunwoodie SL; Bunting KD; Yang YC. 2012. HIF-1alpha deletion partially rescues defects of hematopoietic stem cell quiescence caused by Cited2 deficiency. Blood 119(12):2789-98. [PubMed: 22308296]  [MGI Ref ID J:182527]

Du J; Liu Y; Meline B; Kong G; Tan LX; Lo JC; Wang J; Ranheim E; Zhang L; Chang YI; Ryu MJ; Zhang JF; Zhang J. 2013. Loss of CD44 attenuates aberrant GM-CSF signaling in Kras G12D hematopoietic progenitor/precursor cells and prolongs the survival of diseased animals. Leukemia 27(3):754-7. [PubMed: 22976127]  [MGI Ref ID J:196802]

Durant L; Watford WT; Ramos HL; Laurence A; Vahedi G; Wei L; Takahashi H; Sun HW; Kanno Y; Powrie F; O'Shea JJ. 2010. Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis. Immunity 32(5):605-15. [PubMed: 20493732]  [MGI Ref ID J:160679]

Duy C; Yu JJ; Nahar R; Swaminathan S; Kweon SM; Polo JM; Valls E; Klemm L; Shojaee S; Cerchietti L; Schuh W; Jack HM; Hurtz C; Ramezani-Rad P; Herzog S; Jumaa H; Koeffler HP; de Alboran IM; Melnick AM; Ye BH; Muschen M. 2010. BCL6 is critical for the development of a diverse primary B cell repertoire. J Exp Med 207(6):1209-21. [PubMed: 20498019]  [MGI Ref ID J:163422]

Eferl R; Ricci R; Kenner L; Zenz R; David JP; Rath M; Wagner EF. 2003. Liver Tumor Development. c-Jun Antagonizes the Proapoptotic Activity of p53. Cell 112(2):181-92. [PubMed: 12553907]  [MGI Ref ID J:81543]

Ehninger A; Boch T; Medyouf H; Mudder K; Orend G; Trumpp A. 2014. Loss of SPARC protects hematopoietic stem cells from chemotherapy toxicity by accelerating their return to quiescence. Blood 123(26):4054-63. [PubMed: 24833352]  [MGI Ref ID J:213736]

El Andaloussi A; Graves S; Meng F; Mandal M; Mashayekhi M; Aifantis I. 2006. Hedgehog signaling controls thymocyte progenitor homeostasis and differentiation in the thymus. Nat Immunol 7(4):418-26. [PubMed: 16518394]  [MGI Ref ID J:112555]

Elliott ER; Van Ziffle JA; Scapini P; Sullivan BM; Locksley RM; Lowell CA. 2011. Deletion of Syk in neutrophils prevents immune complex arthritis. J Immunol 187(8):4319-30. [PubMed: 21918195]  [MGI Ref ID J:179306]

Elyaman W; Bassil R; Bradshaw EM; Orent W; Lahoud Y; Zhu B; Radtke F; Yagita H; Khoury SJ. 2012. Notch receptors and Smad3 signaling cooperate in the induction of interleukin-9-producing T cells. Immunity 36(4):623-34. [PubMed: 22503540]  [MGI Ref ID J:187328]

Endo Y; Zhang M; Yamaji S; Cang Y. 2012. Genetic abolishment of hepatocyte proliferation activates hepatic stem cells. PLoS One 7(2):e31846. [PubMed: 22384083]  [MGI Ref ID J:185302]

Enquist IB; Nilsson E; Ooka A; Mansson JE; Olsson K; Ehinger M; Brady RO; Richter J; Karlsson S. 2006. Effective cell and gene therapy in a murine model of Gaucher disease. Proc Natl Acad Sci U S A 103(37):13819-24. [PubMed: 16954197]  [MGI Ref ID J:113751]

Escribano O; Guillen C; Nevado C; Gomez-Hernandez A; Kahn CR; Benito M. 2009. Beta-Cell hyperplasia induced by hepatic insulin resistance: role of a liver-pancreas endocrine axis through insulin receptor A isoform. Diabetes 58(4):820-8. [PubMed: 19136656]  [MGI Ref ID J:151043]

Factor VM; Seo D; Ishikawa T; Kaposi-Novak P; Marquardt JU; Andersen JB; Conner EA; Thorgeirsson SS. 2010. Loss of c-Met disrupts gene expression program required for G2/M progression during liver regeneration in mice. PLoS One 5(9):. [PubMed: 20862286]  [MGI Ref ID J:220946]

Fan Q; Gu D; Liu H; Yang L; Zhang X; Yoder MC; Kaplan MH; Xie J. 2014. Defective TGF-beta signaling in bone marrow-derived cells prevents hedgehog-induced skin tumors. Cancer Res 74(2):471-83. [PubMed: 24282281]  [MGI Ref ID J:206729]

Farfel-Becker T; Vitner EB; Futerman AH. 2011. Animal models for Gaucher disease research. Dis Model Mech 4(6):746-52. [PubMed: 21954067]  [MGI Ref ID J:177669]

Feig JE; Parathath S; Rong JX; Mick SL; Vengrenyuk Y; Grauer L; Young SG; Fisher EA. 2011. Reversal of hyperlipidemia with a genetic switch favorably affects the content and inflammatory state of macrophages in atherosclerotic plaques. Circulation 123(9):989-98. [PubMed: 21339485]  [MGI Ref ID J:183750]

Ficara F; Murphy MJ; Lin M; Cleary ML. 2008. Pbx1 regulates self-renewal of long-term hematopoietic stem cells by maintaining their quiescence. Cell Stem Cell 2(5):484-96. [PubMed: 18462698]  [MGI Ref ID J:149799]

Finch AJ; Hilcenko C; Basse N; Drynan LF; Goyenechea B; Menne TF; Gonzalez Fernandez A; Simpson P; D'Santos CS; Arends MJ; Donadieu J; Bellanne-Chantelot C; Costanzo M; Boone C; McKenzie AN; Freund SM; Warren AJ. 2011. Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome. Genes Dev 25(9):917-29. [PubMed: 21536732]  [MGI Ref ID J:171416]

Flick MJ; Du X; Prasad JM; Raghu H; Palumbo JS; Smeds E; Hook M; Degen JL. 2013. Genetic elimination of the binding motif on fibrinogen for the S. aureus virulence factor ClfA improves host survival in septicemia. Blood 121(10):1783-94. [PubMed: 23299312]  [MGI Ref ID J:194757]

Foldi J; Chung AY; Xu H; Zhu J; Outtz HH; Kitajewski J; Li Y; Hu X; Ivashkiv LB. 2010. Autoamplification of Notch signaling in macrophages by TLR-induced and RBP-J-dependent induction of Jagged1. J Immunol 185(9):5023-31. [PubMed: 20870935]  [MGI Ref ID J:165202]

Foley SB; Hildenbrand ZL; Soyombo AA; Magee JA; Wu Y; Oravecz-Wilson KI; Ross TS. 2013. Expression of BCR/ABL p210 from a knockin allele enhances bone marrow engraftment without inducing neoplasia. Cell Rep 5(1):51-60. [PubMed: 24095735]  [MGI Ref ID J:203111]

Forand A; Beck L; Leroy C; Rousseau A; Boitez V; Cohen I; Courtois G; Hermine O; Friedlander G. 2013. EKLF-driven PIT1 expression is critical for mouse erythroid maturation in vivo and in vitro. Blood 121(4):666-78. [PubMed: 23190530]  [MGI Ref ID J:194198]

Foudi A; Kramer DJ; Qin J; Ye D; Behlich AS; Mordecai S; Preffer FI; Amzallag A; Ramaswamy S; Hochedlinger K; Orkin SH; Hock H. 2014. Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation. J Exp Med :. [PubMed: 24711581]  [MGI Ref ID J:207446]

Frelin C; Herrington R; Janmohamed S; Barbara M; Tran G; Paige CJ; Benveniste P; Zuniga-Pflucker JC; Souabni A; Busslinger M; Iscove NN. 2013. GATA-3 regulates the self-renewal of long-term hematopoietic stem cells. Nat Immunol 14(10):1037-44. [PubMed: 23974957]  [MGI Ref ID J:208223]

Fu J; Gerhardt H; McDaniel JM; Xia B; Liu X; Ivanciu L; Ny A; Hermans K; Silasi-Mansat R; McGee S; Nye E; Ju T; Ramirez MI; Carmeliet P; Cummings RD; Lupu F; Xia L. 2008. Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice. J Clin Invest 118(11):3725-37. [PubMed: 18924607]  [MGI Ref ID J:144581]

Fu W; Ergun A; Lu T; Hill JA; Haxhinasto S; Fassett MS; Gazit R; Adoro S; Glimcher L; Chan S; Kastner P; Rossi D; Collins JJ; Mathis D; Benoist C. 2012. A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells. Nat Immunol 13(10):972-80. [PubMed: 22961053]  [MGI Ref ID J:187667]

Fujii T; Ueda T; Nagata S; Fukunaga R. 2010. Essential role of p400/mDomino chromatin-remodeling ATPase in bone marrow hematopoiesis and cell-cycle progression. J Biol Chem 285(39):30214-23. [PubMed: 20610385]  [MGI Ref ID J:166397]

Fukuda S; Hoggatt J; Singh P; Abe M; Speth JM; Hu P; Conway EM; Nucifora G; Yamaguchi S; Pelus LM. 2015. Survivin modulates genes with divergent molecular functions and regulates proliferation of hematopoietic stem cells through Evi-1. Leukemia 29(2):433-40. [PubMed: 24903482]  [MGI Ref ID J:217841]

Gaba A; Grivennikov SI; Do MV; Stumpo DJ; Blackshear PJ; Karin M. 2012. Cutting edge: IL-10-mediated tristetraprolin induction is part of a feedback loop that controls macrophage STAT3 activation and cytokine production. J Immunol 189(5):2089-93. [PubMed: 22865915]  [MGI Ref ID J:189846]

Galan-Caridad JM; Harel S; Arenzana TL; Hou ZE; Doetsch FK; Mirny LA; Reizis B. 2007. Zfx controls the self-renewal of embryonic and hematopoietic stem cells. Cell 129(2):345-57. [PubMed: 17448993]  [MGI Ref ID J:149654]

Gall A; Treuting P; Elkon KB; Loo YM; Gale M Jr; Barber GN; Stetson DB. 2012. Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease. Immunity 36(1):120-31. [PubMed: 22284419]  [MGI Ref ID J:181257]

Gallo EM; Ho L; Winslow MM; Staton TL; Crabtree GR. 2008. Selective role of calcineurin in haematopoiesis and lymphopoiesis. EMBO Rep 9(11):1141-8. [PubMed: 18818667]  [MGI Ref ID J:143345]

Gao C; Kozlowska A; Nechaev S; Li H; Zhang Q; Hossain DM; Kowolik CM; Chu P; Swiderski P; Diamond DJ; Pal SK; Raubitschek A; Kortylewski M. 2013. TLR9 signaling in the tumor microenvironment initiates cancer recurrence after radiotherapy. Cancer Res 73(24):7211-21. [PubMed: 24154870]  [MGI Ref ID J:206520]

Gao J; Graves S; Koch U; Liu S; Jankovic V; Buonamici S; El Andaloussi A; Nimer SD; Kee BL; Taichman R; Radtke F; Aifantis I. 2009. Hedgehog signaling is dispensable for adult hematopoietic stem cell function. Cell Stem Cell 4(6):548-58. [PubMed: 19497283]  [MGI Ref ID J:149820]

Garcia P; Berlanga O; Watson R; Frampton J. 2005. Generation of a conditional allele of the B-myb gene. Genesis 43(4):189-95. [PubMed: 16283626]  [MGI Ref ID J:103413]

Garfin PM; Min D; Bryson JL; Serwold T; Edris B; Blackburn CC; Richie ER; Weinberg KI; Manley NR; Sage J; Viatour P. 2013. Inactivation of the RB family prevents thymus involution and promotes thymic function by direct control of Foxn1 expression. J Exp Med 210(6):1087-97. [PubMed: 23669396]  [MGI Ref ID J:200953]

Ge J; Crosby SD; Heinz ME; Bessler M; Mason PJ. 2010. SnoRNA microarray analysis reveals changes in H/ACA and C/D RNA levels caused by dyskerin ablation in mouse liver. Biochem J 429(1):33-41. [PubMed: 20423331]  [MGI Ref ID J:164467]

Ge J; Rudnick DA; He J; Crimmins DL; Ladenson JH; Bessler M; Mason PJ. 2010. Dyskerin ablation in mouse liver inhibits rRNA processing and cell division. Mol Cell Biol 30(2):413-22. [PubMed: 19917719]  [MGI Ref ID J:156403]

Geisler F; Algul H; Paxian S; Schmid RM. 2007. Genetic inactivation of RelA/p65 sensitizes adult mouse hepatocytes to TNF-induced apoptosis in vivo and in vitro. Gastroenterology 132(7):2489-503. [PubMed: 17570221]  [MGI Ref ID J:128311]

Genetic Resource Science at The Jackson Laboratory. 2013. Expression/Specificity Patterns of Cre Alleles, 2013 Direct Data Submission from Genetic Resource Science :.  [MGI Ref ID J:193672]

Gerbaulet A; Wickenhauser C; Scholten J; Peschke K; Drube S; Horny HP; Kamradt T; Naumann R; Muller W; Krieg T; Waskow C; Hartmann K; Roers A. 2011. Mast cell hyperplasia, B-cell malignancy, and intestinal inflammation in mice with conditional expression of a constitutively active kit. Blood 117(6):2012-21. [PubMed: 21148330]  [MGI Ref ID J:169611]

Gerber HP; Hillan KJ; Ryan AM; Kowalski J; Keller GA; Rangell L ; Wright BD ; Radtke F ; Aguet M ; Ferrara N. 1999. VEGF is required for growth and survival in neonatal mice. Development 126(6):1149-59. [PubMed: 10021335]  [MGI Ref ID J:52793]

Gerber HP; Malik AK; Solar GP; Sherman D; Liang XH; Meng G; Hong K; Marsters JC; Ferrara N. 2002. VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism. Nature 417(6892):954-8. [PubMed: 12087404]  [MGI Ref ID J:77388]

Germar K; Dose M; Konstantinou T; Zhang J; Wang H; Lobry C; Arnett KL; Blacklow SC; Aifantis I; Aster JC; Gounari F. 2011. T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling. Proc Natl Acad Sci U S A 108(50):20060-5. [PubMed: 22109558]  [MGI Ref ID J:180443]

Golan K; Vagima Y; Ludin A; Itkin T; Cohen-Gur S; Kalinkovich A; Kollet O; Kim C; Schajnovitz A; Ovadya Y; Lapid K; Shivtiel S; Morris AJ; Ratajczak MZ; Lapidot T. 2012. S1P promotes murine progenitor cell egress and mobilization via S1P1-mediated ROS signaling and SDF-1 release. Blood 119(11):2478-88. [PubMed: 22279055]  [MGI Ref ID J:182535]

Gonzalez-Nieto D; Li L; Kohler A; Ghiaur G; Ishikawa E; Sengupta A; Madhu M; Arnett JL; Santho RA; Dunn SK; Fishman GI; Gutstein DE; Civitelli R; Barrio LC; Gunzer M; Cancelas JA. 2012. Connexin-43 in the osteogenic BM niche regulates its cellular composition and the bidirectional traffic of hematopoietic stem cells and progenitors. Blood 119(22):5144-54. [PubMed: 22498741]  [MGI Ref ID J:185148]

Goodwin CB; Li XJ; Mali RS; Chan G; Kang M; Liu Z; Vanhaesebroeck B; Neel BG; Loh ML; Lannutti BJ; Kapur R; Chan RJ. 2014. PI3K p110delta uniquely promotes gain-of-function Shp2-induced GM-CSF hypersensitivity in a model of JMML. Blood 123(18):2838-42. [PubMed: 24553178]  [MGI Ref ID J:210890]

Goren A; Simchen G; Fibach E; Szabo PE; Tanimoto K; Chakalova L; Pfeifer GP; Fraser PJ; Engel JD; Cedar H. 2006. Fine tuning of globin gene expression by DNA methylation. PLoS ONE 1:e46. [PubMed: 17183675]  [MGI Ref ID J:129359]

Gorjestani S; Yu M; Tang B; Zhang D; Wang D; Lin X. 2011. Phospholipase Cgamma2 (PLCgamma2) Is Key Component in Dectin-2 Signaling Pathway, Mediating Anti-fungal Innate Immune Responses. J Biol Chem 286(51):43651-9. [PubMed: 22041900]  [MGI Ref ID J:178744]

Gotthardt D; Putz EM; Straka E; Kudweis P; Biaggio M; Poli V; Strobl B; Muller M; Sexl V. 2014. Loss of STAT3 in murine NK cells enhances NK cell-dependent tumor surveillance. Blood 124(15):2370-9. [PubMed: 25185262]  [MGI Ref ID J:218699]

Gough DJ; Marie IJ; Lobry C; Aifantis I; Levy DE. 2014. STAT3 supports experimental K-RasG12D-induced murine myeloproliferative neoplasms dependent on serine phosphorylation. Blood 124(14):2252-61. [PubMed: 25150294]  [MGI Ref ID J:218707]

Goyama S; Yamamoto G; Shimabe M; Sato T; Ichikawa M; Ogawa S; Chiba S; Kurokawa M. 2008. Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells. Cell Stem Cell 3(2):207-20. [PubMed: 18682242]  [MGI Ref ID J:149794]

Graves CW; Philips ST; Bradley SV; Oravecz-Wilson KI; Li L; Gauvin A; Ross TS. 2008. Use of a cryptic splice site for the expression of huntingtin interacting protein 1 in select normal and neoplastic tissues. Cancer Res 68(4):1064-73. [PubMed: 18281481]  [MGI Ref ID J:131697]

Grech AP; Amesbury M; Chan T; Gardam S; Basten A; Brink R. 2004. TRAF2 differentially regulates the canonical and noncanonical pathways of NF-kappaB activation in mature B cells. Immunity 21(5):629-42. [PubMed: 15539150]  [MGI Ref ID J:93890]

Green JA; Suzuki K; Cho B; Willison LD; Palmer D; Allen CD; Schmidt TH; Xu Y; Proia RL; Coughlin SR; Cyster JG. 2011. The sphingosine 1-phosphate receptor S1P maintains the homeostasis of germinal center B cells and promotes niche confinement. Nat Immunol 12(7):672-80. [PubMed: 21642988]  [MGI Ref ID J:174313]

Greenblatt MB; Aliprantis A; Hu B; Glimcher LH. 2010. Calcineurin regulates innate antifungal immunity in neutrophils. J Exp Med 207(5):923-31. [PubMed: 20421389]  [MGI Ref ID J:160937]

Greten FR; Arkan MC; Bollrath J; Hsu LC; Goode J; Miething C; Goktuna SI; Neuenhahn M; Fierer J; Paxian S; Van Rooijen N; Xu Y; O'Cain T; Jaffee BB; Busch DH; Duyster J; Schmid RM; Eckmann L; Karin M. 2007. NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta. Cell 130(5):918-31. [PubMed: 17803913]  [MGI Ref ID J:129928]

Gritsman K; Yuzugullu H; Von T; Yan H; Clayton L; Fritsch C; Maira SM; Hollingworth G; Choi C; Khandan T; Paktinat M; Okabe RO; Roberts TM; Zhao JJ. 2014. Hematopoiesis and RAS-driven myeloid leukemia differentially require PI3K isoform p110alpha. J Clin Invest 124(4):1794-809. [PubMed: 24569456]  [MGI Ref ID J:209632]

Grover A; Mancini E; Moore S; Mead AJ; Atkinson D; Rasmussen KD; O'Carroll D; Jacobsen SE; Nerlov C. 2014. Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate. J Exp Med 211(2):181-8. [PubMed: 24493804]  [MGI Ref ID J:208436]

Growney JD; Shigematsu H; Li Z; Lee BH; Adelsperger J; Rowan R; Curley DP; Kutok JL; Akashi K; Williams IR; Speck NA; Gilliland DG. 2005. Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype. Blood 106(2):494-504. [PubMed: 15784726]  [MGI Ref ID J:107469]

Gruber JJ; Zatechka DS; Sabin LR; Yong J; Lum JJ; Kong M; Zong WX; Zhang Z; Lau CK; Rawlings J; Cherry S; Ihle JN; Dreyfuss G; Thompson CB. 2009. Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation. Cell 138(2):328-39. [PubMed: 19632182]  [MGI Ref ID J:152729]

Guitart AV; Subramani C; Armesilla-Diaz A; Smith G; Sepulveda C; Gezer D; Vukovic M; Dunn K; Pollard P; Holyoake TL; Enver T; Ratcliffe PJ; Kranc KR. 2013. Hif-2alpha is not essential for cell-autonomous hematopoietic stem cell maintenance. Blood 122(10):1741-5. [PubMed: 23894152]  [MGI Ref ID J:202361]

Guo F; Cancelas JA; Hildeman D; Williams DA; Zheng Y. 2008. Rac GTPase isoforms Rac1 and Rac2 play a redundant and crucial role in T-cell development. Blood 112(5):1767-75. [PubMed: 18579797]  [MGI Ref ID J:138889]

Guo F; Li J; Du W; Zhang S; O'Connor M; Thomas G; Kozma S; Zingarelli B; Pang Q; Zheng Y. 2013. mTOR regulates DNA damage response through NF-kappaB-mediated FANCD2 pathway in hematopoietic cells. Leukemia 27(10):2040-6. [PubMed: 23538752]  [MGI Ref ID J:201860]

Guo F; Velu CS; Grimes HL; Zheng Y. 2009. Rho GTPase Cdc42 is essential for B-lymphocyte development and activation. Blood 114(14):2909-16. [PubMed: 19671922]  [MGI Ref ID J:153368]

Guo F; Zhang S; Grogg M; Cancelas JA; Varney ME; Starczynowski DT; Du W; Yang JQ; Liu W; Thomas G; Kozma S; Pang Q; Zheng Y. 2013. Mouse gene targeting reveals an essential role of mTOR in hematopoietic stem cell engraftment and hematopoiesis. Haematologica 98(9):1353-8. [PubMed: 23716557]  [MGI Ref ID J:205539]

Guo S; Lu J; Schlanger R; Zhang H; Wang JY; Fox MC; Purton LE; Fleming HH; Cobb B; Merkenschlager M; Golub TR; Scadden DT. 2010. MicroRNA miR-125a controls hematopoietic stem cell number. Proc Natl Acad Sci U S A 107(32):14229-34. [PubMed: 20616003]  [MGI Ref ID J:163479]

Guo Y; Niu C; Breslin P; Tang M; Zhang S; Wei W; Kini AR; Paner GP; Alkan S; Morris SW; Diaz M; Stiff PJ; Zhang J. 2009. c-Myc-mediated control of cell fate in megakaryocyte-erythrocyte progenitors. Blood 114(10):2097-106. [PubMed: 19372257]  [MGI Ref ID J:152282]

Gupte R; Muse GW; Chinenov Y; Adelman K; Rogatsky I. 2013. Glucocorticoid receptor represses proinflammatory genes at distinct steps of the transcription cycle. Proc Natl Acad Sci U S A 110(36):14616-21. [PubMed: 23950223]  [MGI Ref ID J:200982]

Gusarova GA; Wang IC; Major ML; Kalinichenko VV; Ackerson T; Petrovic V; Costa RH. 2007. A cell-penetrating ARF peptide inhibitor of FoxM1 in mouse hepatocellular carcinoma treatment. J Clin Invest 117(1):99-111. [PubMed: 17173139]  [MGI Ref ID J:117461]

Gutierrez L; Tsukamoto S; Suzuki M; Yamamoto-Mukai H; Yamamoto M; Philipsen S; Ohneda K. 2008. Ablation of Gata1 in adult mice results in aplastic crisis, revealing its essential role in steady-state and stress erythropoiesis. Blood 111(8):4375-85. [PubMed: 18258797]  [MGI Ref ID J:134354]

Hakem A; El Ghamrasni S; Maire G; Lemmers B; Karaskova J; Jurisicova A; Sanchez O; Squire J; Hakem R. 2012. Caspase-8 is essential for maintaining chromosomal stability and suppressing B-cell lymphomagenesis. Blood 119(15):3495-502. [PubMed: 22343728]  [MGI Ref ID J:183787]

Hall MA; Curtis DJ; Metcalf D; Elefanty AG; Sourris K; Robb L; Gothert JR; Jane SM; Begley CG. 2003. The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12. Proc Natl Acad Sci U S A 100(3):992-7. [PubMed: 12552125]  [MGI Ref ID J:81826]

Hall MA; Slater NJ; Begley CG; Salmon JM; Van Stekelenburg LJ; McCormack MP; Jane SM; Curtis DJ. 2005. Functional but abnormal adult erythropoiesis in the absence of the stem cell leukemia gene. Mol Cell Biol 25(15):6355-62. [PubMed: 16024775]  [MGI Ref ID J:100016]

Han H; Tanigaki K; Yamamoto N; Kuroda K; Yoshimoto M; Nakahata T; Ikuta K; Honjo T. 2002. Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision. Int Immunol 14(6):637-45. [PubMed: 12039915]  [MGI Ref ID J:99747]

Hao Z; Hampel B; Yagita H; Rajewsky K. 2004. T cell-specific ablation of Fas leads to Fas ligand-mediated lymphocyte depletion and inflammatory pulmonary fibrosis. J Exp Med 199(10):1355-65. [PubMed: 15148335]  [MGI Ref ID J:114948]

Hao Z; Rajewsky K. 2001. Homeostasis of peripheral b cells in the absence of b cell influx from the bone marrow. J Exp Med 194(8):1151-64. [PubMed: 11602643]  [MGI Ref ID J:72214]

Hara T; Nakamura K; Matsui M; Yamamoto A; Nakahara Y; Suzuki-Migishima R; Yokoyama M; Mishima K; Saito I; Okano H; Mizushima N. 2006. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 441(7095):885-9. [PubMed: 16625204]  [MGI Ref ID J:110050]

Hartner JC; Walkley CR; Lu J; Orkin SH. 2009. ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling. Nat Immunol 10(1):109-15. [PubMed: 19060901]  [MGI Ref ID J:142338]

Hasemann MS; Lauridsen FK; Waage J; Jakobsen JS; Frank AK; Schuster MB; Rapin N; Bagger FO; Hoppe PS; Schroeder T; Porse BT. 2014. C/EBPalpha is required for long-term self-renewal and lineage priming of hematopoietic stem cells and for the maintenance of epigenetic configurations in multipotent progenitors. PLoS Genet 10(1):e1004079. [PubMed: 24415956]  [MGI Ref ID J:208818]

Hasenfuss SC; Bakiri L; Thomsen MK; Williams EG; Auwerx J; Wagner EF. 2014. Regulation of steatohepatitis and PPARgamma signaling by distinct AP-1 dimers. Cell Metab 19(1):84-95. [PubMed: 24411941]  [MGI Ref ID J:210545]

Hashimoto A; Takeda K; Inaba M; Sekimata M; Kaisho T; Ikehara S; Homma Y; Akira S; Kurosaki T. 2000. Cutting edge: essential role of phospholipase C-gamma 2 in B cell development and function. J Immunol 165(4):1738-42. [PubMed: 10925250]  [MGI Ref ID J:63744]

Hashimoto D; Chow A; Noizat C; Teo P; Beasley MB; Leboeuf M; Becker CD; See P; Price J; Lucas D; Greter M; Mortha A; Boyer SW; Forsberg EC; Tanaka M; van Rooijen N; Garcia-Sastre A; Stanley ER; Ginhoux F; Frenette PS; Merad M. 2013. Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes. Immunity 38(4):792-804. [PubMed: 23601688]  [MGI Ref ID J:196958]

Hasselblatt P; Rath M; Komnenovic V; Zatloukal K; Wagner EF. 2007. Hepatocyte survival in acute hepatitis is due to c-Jun/AP-1-dependent expression of inducible nitric oxide synthase. Proc Natl Acad Sci U S A 104(43):17105-10. [PubMed: 17940019]  [MGI Ref ID J:125913]

Hayashi M; Fearns C; Eliceiri B; Yang Y; Lee JD. 2005. Big mitogen-activated protein kinase 1/extracellular signal-regulated kinase 5 signaling pathway is essential for tumor-associated angiogenesis. Cancer Res 65(17):7699-706. [PubMed: 16140937]  [MGI Ref ID J:101725]

Hayashi M; Kim SW; Imanaka-Yoshida K; Yoshida T; Abel ED; Eliceiri B; Yang Y; Ulevitch RJ; Lee JD. 2004. Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure. J Clin Invest 113(8):1138-48. [PubMed: 15085193]  [MGI Ref ID J:89215]

Hazen AL; Smith MJ; Desponts C; Winter O; Moser K; Kerr WG. 2009. SHIP is required for a functional hematopoietic stem cell niche. Blood 113(13):2924-33. [PubMed: 19074735]  [MGI Ref ID J:146931]

He G; Yu GY; Temkin V; Ogata H; Kuntzen C; Sakurai T; Sieghart W; Peck-Radosavljevic M; Leffert HL; Karin M. 2010. Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation. Cancer Cell 17(3):286-97. [PubMed: 20227042]  [MGI Ref ID J:158659]

He XC; Yin T; Grindley JC; Tian Q; Sato T; Tao WA; Dirisina R; Porter-Westpfahl KS; Hembree M; Johnson T; Wiedemann LM; Barrett TA; Hood L; Wu H; Li L. 2007. PTEN-deficient intestinal stem cells initiate intestinal polyposis. Nat Genet 39(2):189-98. [PubMed: 17237784]  [MGI Ref ID J:118329]

He XC; Zhang J; Tong WG; Tawfik O; Ross J; Scoville DH; Tian Q; Zeng X; He X; Wiedemann LM; Mishina Y; Li L. 2004. BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling. Nat Genet 36(10):1117-21. [PubMed: 15378062]  [MGI Ref ID J:93850]

Hegde S; Ni S; He S; Yoon D; Feng GS; Watowich SS; Paulson RF; Hankey PA. 2009. Stat3 promotes the development of erythroleukemia by inducing Pu.1 expression and inhibiting erythroid differentiation. Oncogene 28(38):3349-59. [PubMed: 19581930]  [MGI Ref ID J:157335]

Heidel FH; Bullinger L; Arreba-Tutusaus P; Wang Z; Gaebel J; Hirt C; Niederwieser D; Lane SW; Dohner K; Vasioukhin V; Fischer T; Armstrong SA. 2013. The cell fate determinant Llgl1 influences HSC fitness and prognosis in AML. J Exp Med 210(1):15-22. [PubMed: 23277453]  [MGI Ref ID J:194775]

Heilman SA; Kuo YH; Goudswaard CS; Valk PJ; Castilla LH. 2006. Cbfbeta reduces Cbfbeta-SMMHC-associated acute myeloid leukemia in mice. Cancer Res 66(23):11214-8. [PubMed: 17145866]  [MGI Ref ID J:116203]

Herrmann A; Kortylewski M; Kujawski M; Zhang C; Reckamp K; Armstrong B; Wang L; Kowolik C; Deng J; Figlin R; Yu H. 2010. Targeting Stat3 in the myeloid compartment drastically improves the in vivo antitumor functions of adoptively transferred T cells. Cancer Res 70(19):7455-64. [PubMed: 20841481]  [MGI Ref ID J:164674]

Herzog BH; Fu J; Wilson SJ; Hess PR; Sen A; McDaniel JM; Pan Y; Sheng M; Yago T; Silasi-Mansat R; McGee S; May F; Nieswandt B; Morris AJ; Lupu F; Coughlin SR; McEver RP; Chen H; Kahn ML; Xia L. 2013. Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature 502(7469):105-9. [PubMed: 23995678]  [MGI Ref ID J:205423]

Hetz C; Bernasconi P; Fisher J; Lee AH; Bassik MC; Antonsson B; Brandt GS; Iwakoshi NN; Schinzel A; Glimcher LH; Korsmeyer SJ. 2006. Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha. Science 312(5773):572-6. [PubMed: 16645094]  [MGI Ref ID J:108337]

Hevener AL; Olefsky JM; Reichart D; Nguyen MT; Bandyopadyhay G; Leung HY; Watt MJ; Benner C; Febbraio MA; Nguyen AK; Folian B; Subramaniam S; Gonzalez FJ; Glass CK; Ricote M. 2007. Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. J Clin Invest 117(6):1658-69. [PubMed: 17525798]  [MGI Ref ID J:122186]

Higuchi M; O'Brien D; Kumaravelu P; Lenny N; Yeoh EJ; Downing JR. 2002. Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia. Cancer Cell 1(1):63-74. [PubMed: 12086889]  [MGI Ref ID J:77129]

Hirai H; Zhang P; Dayaram T; Hetherington CJ; Mizuno S; Imanishi J; Akashi K; Tenen DG. 2006. C/EBPbeta is required for 'emergency' granulopoiesis. Nat Immunol 7(7):732-9. [PubMed: 16751774]  [MGI Ref ID J:112664]

Hobbs CM; Manning H; Bennett C; Vasquez L; Severin S; Brain L; Mazharian A; Guerrero JA; Li J; Soranzo N; Green AR; Watson SP; Ghevaert C. 2013. JAK2V617F leads to intrinsic changes in platelet formation and reactivity in a knock-in mouse model of essential thrombocythemia. Blood 122(23):3787-97. [PubMed: 24085768]  [MGI Ref ID J:204599]

Hock H; Meade E; Medeiros S; Schindler JW; Valk PJ; Fujiwara Y; Orkin SH. 2004. Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival. Genes Dev 18(19):2336-41. [PubMed: 15371326]  [MGI Ref ID J:93052]

Hofmann I; Stover EH; Cullen DE; Mao J; Morgan KJ; Lee BH; Kharas MG; Miller PG; Cornejo MG; Okabe R; Armstrong SA; Ghilardi N; Gould S; de Sauvage FJ; McMahon AP; Gilliland DG. 2009. Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis. Cell Stem Cell 4(6):559-67. [PubMed: 19497284]  [MGI Ref ID J:149819]

Horcher M; Souabni A; Busslinger M. 2001. Pax5/BSAP maintains the identity of B cells in late B lymphopoiesis. Immunity 14(6):779-90. [PubMed: 11420047]  [MGI Ref ID J:75504]

Horiuchi K; Kimura T; Miyamoto T; Takaishi H; Okada Y; Toyama Y; Blobel CP. 2007. Cutting edge: TNF-alpha-converting enzyme (TACE/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock. J Immunol 179(5):2686-9. [PubMed: 17709479]  [MGI Ref ID J:139846]

Horiuchi K; Morioka H; Takaishi H; Akiyama H; Blobel CP; Toyama Y. 2009. Ectodomain shedding of FLT3 ligand is mediated by TNF-alpha converting enzyme. J Immunol 182(12):7408-14. [PubMed: 19494263]  [MGI Ref ID J:149303]

Horman SR; Velu CS; Chaubey A; Bourdeau T; Zhu J; Paul WE; Gebelein B; Grimes HL. 2009. Gfi1 integrates progenitor versus granulocytic transcriptional programming. Blood 113(22):5466-75. [PubMed: 19346496]  [MGI Ref ID J:148893]

Hosoya T; Clifford M; Losson R; Tanabe O; Engel JD. 2013. TRIM28 is essential for erythroblast differentiation in the mouse. Blood 122(23):3798-807. [PubMed: 24092935]  [MGI Ref ID J:204593]

Hosoya T; Kuroha T; Moriguchi T; Cummings D; Maillard I; Lim KC; Engel JD. 2009. GATA-3 is required for early T lineage progenitor development. J Exp Med 206(13):2987-3000. [PubMed: 19934022]  [MGI Ref ID J:155686]

Hossain DM; Dos Santos C; Zhang Q; Kozlowska A; Liu H; Gao C; Moreira D; Swiderski P; Jozwiak A; Kline J; Forman S; Bhatia R; Kuo YH; Kortylewski M. 2014. Leukemia cell-targeted STAT3 silencing and TLR9 triggering generate systemic antitumor immunity. Blood 123(1):15-25. [PubMed: 24169824]  [MGI Ref ID J:207711]

Hozumi K; Negishi N; Suzuki D; Abe N; Sotomaru Y; Tamaoki N; Mailhos C; Ish-Horowicz D; Habu S; Owen MJ. 2004. Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo. Nat Immunol 5(6):638-44. [PubMed: 15146182]  [MGI Ref ID J:90630]

Hsieh YT; Gang EJ; Geng H; Park E; Huantes S; Chudziak D; Dauber K; Schaefer P; Scharman C; Shimada H; Shojaee S; Klemm L; Parameswaran R; Loh M; Kang ES; Koo HH; Hofmann WK; Andrade J; Crooks GM; Willman CL; Muschen M; Papayannopoulou T; Heisterkamp N; Bonig H; Kim YM. 2013. Integrin alpha4 blockade sensitizes drug resistant pre-B acute lymphoblastic leukemia to chemotherapy. Blood 121(10):1814-8. [PubMed: 23319569]  [MGI Ref ID J:195422]

Hsu LC; Enzler T; Seita J; Timmer AM; Lee CY; Lai TY; Yu GY; Lai LC; Temkin V; Sinzig U; Aung T; Nizet V; Weissman IL; Karin M. 2011. IL-1beta-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKbeta. Nat Immunol 12(2):144-50. [PubMed: 21170027]  [MGI Ref ID J:169021]

Hu P; Carlesso N; Xu M; Liu Y; Nebreda AR; Takemoto C; Kapur R. 2012. Genetic evidence for critical roles of P38alpha protein in regulating mast cell differentiation and chemotaxis through distinct mechanisms. J Biol Chem 287(24):20258-69. [PubMed: 22518842]  [MGI Ref ID J:186514]

Hu P; Nebreda AR; Liu Y; Carlesso N; Kaplan M; Kapur R. 2012. p38alpha protein negatively regulates T helper type 2 responses by orchestrating multiple T cell receptor-associated signals. J Biol Chem 287(40):33215-26. [PubMed: 22859305]  [MGI Ref ID J:191251]

Hu T; Ghazaryan S; Sy C; Wiedmeyer C; Chang V; Wu L. 2012. Concomitant inactivation of Rb and E2f8 in hematopoietic stem cells synergizes to induce severe anemia. Blood 119(19):4532-42. [PubMed: 22422820]  [MGI Ref ID J:185180]

Huang G; Zhang P; Hirai H; Elf S; Yan X; Chen Z; Koschmieder S; Okuno Y; Dayaram T; Growney JD; Shivdasani RA; Gilliland DG; Speck NA; Nimer SD; Tenen DG. 2008. PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis. Nat Genet 40(1):51-60. [PubMed: 17994017]  [MGI Ref ID J:131217]

Huebener P; Gwak GY; Pradere JP; Quinzii CM; Friedman R; Lin CS; Trent CM; Mederacke I; Zhao E; Dapito DH; Lin Y; Goldberg IJ; Czaja MJ; Schwabe RF. 2014. High-mobility group box 1 is dispensable for autophagy, mitochondrial quality control, and organ function in vivo. Cell Metab 19(3):539-47. [PubMed: 24606906]  [MGI Ref ID J:210631]

Huebener P; Pradere JP; Hernandez C; Gwak GY; Caviglia JM; Mu X; Loike JD; Jenkins RE; Antoine DJ; Schwabe RF. 2015. The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis. J Clin Invest 125(2):539-50. [PubMed: 25562324]  [MGI Ref ID J:220563]

Hui L; Bakiri L; Mairhorfer A; Schweifer N; Haslinger C; Kenner L; Komnenovic V; Scheuch H; Beug H; Wagner EF. 2007. p38alpha suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway. Nat Genet 39(6):741-9. [PubMed: 17468757]  [MGI Ref ID J:122396]

Hur KY; So JS; Ruda V; Frank-Kamenetsky M; Fitzgerald K; Koteliansky V; Iwawaki T; Glimcher LH; Lee AH. 2012. IRE1alpha activation protects mice against acetaminophen-induced hepatotoxicity. J Exp Med 209(2):307-18. [PubMed: 22291093]  [MGI Ref ID J:181870]

Ichikawa M; Asai T; Saito T; Yamamoto G; Seo S; Yamazaki I; Yamagata T; Mitani K; Chiba S; Hirai H; Ogawa S; Kurokawa M. 2004. AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis. Nat Med 10(3):299-304. [PubMed: 14966519]  [MGI Ref ID J:88511]

Ichikawa M; Goyama S; Asai T; Kawazu M; Nakagawa M; Takeshita M; Chiba S; Ogawa S; Kurokawa M. 2008. AML1/Runx1 Negatively Regulates Quiescent Hematopoietic Stem Cells in Adult Hematopoiesis. J Immunol 180(7):4402-8. [PubMed: 18354160]  [MGI Ref ID J:132971]

Ikejiri A; Nagai S; Goda N; Kurebayashi Y; Osada-Oka M; Takubo K; Suda T; Koyasu S. 2012. Dynamic regulation of Th17 differentiation by oxygen concentrations. Int Immunol 24(3):137-46. [PubMed: 22207131]  [MGI Ref ID J:182569]

Ikushima YM; Arai F; Nakamura Y; Hosokawa K; Kubota Y; Hirashima M; Toyama H; Suda T. 2013. Enhanced Angpt1/Tie2 signaling affects the differentiation and long-term repopulation ability of hematopoietic stem cells. Biochem Biophys Res Commun 430(1):20-5. [PubMed: 23149415]  [MGI Ref ID J:193742]

Ippolito GC; Dekker JD; Wang YH; Lee BK; Shaffer AL 3rd; Lin J; Wall JK; Lee BS; Staudt LM; Liu YJ; Iyer VR; Tucker HO. 2014. Dendritic cell fate is determined by BCL11A. Proc Natl Acad Sci U S A 111(11):E998-E1006. [PubMed: 24591644]  [MGI Ref ID J:207383]

Iqbal J; Rudel LL; Hussain MM. 2008. Microsomal triglyceride transfer protein enhances cellular cholesteryl esterification by relieving product inhibition. J Biol Chem 283(29):19967-80. [PubMed: 18502767]  [MGI Ref ID J:138737]

Ishikawa Y; Maeda M; Pasham M; Aguet F; Tacheva-Grigorova SK; Masuda T; Yi H; Lee SU; Xu J; Teruya-Feldstein J; Ericsson M; Mullally A; Heuser J; Kirchhausen T; Maeda T. 2015. Role of the clathrin adaptor PICALM in normal hematopoiesis and polycythemia vera pathophysiology. Haematologica 100(4):439-51. [PubMed: 25552701]  [MGI Ref ID J:220728]

Iwasaki H; Somoza C; Shigematsu H; Duprez EA; Iwasaki-Arai J; Mizuno S; Arinobu Y; Geary K; Zhang P; Dayaram T; Fenyus ML; Elf S; Chan S; Kastner P; Huettner CS; Murray R; Tenen DG; Akashi K. 2005. Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation. Blood 106(5):1590-600. [PubMed: 15914556]  [MGI Ref ID J:114150]

Jackson JT; Nasa C; Shi W; Huntington ND; Bogue CW; Alexander WS; McCormack MP. 2015. A crucial role for the homeodomain transcription factor Hhex in lymphopoiesis. Blood 125(5):803-14. [PubMed: 25472970]  [MGI Ref ID J:221385]

Jain P; Coisne C; Enzmann G; Rottapel R; Engelhardt B. 2010. Alpha4beta1 integrin mediates the recruitment of immature dendritic cells across the blood-brain barrier during experimental autoimmune encephalomyelitis. J Immunol 184(12):7196-206. [PubMed: 20483748]  [MGI Ref ID J:161147]

Jantsch J; Schatz V; Friedrich D; Schroder A; Kopp C; Siegert I; Maronna A; Wendelborn D; Linz P; Binger KJ; Gebhardt M; Heinig M; Neubert P; Fischer F; Teufel S; David JP; Neufert C; Cavallaro A; Rakova N; Kuper C; Beck FX; Neuhofer W; Muller DN; Schuler G; Uder M; Bogdan C; Luft FC; Titze J. 2015. Cutaneous Na+ storage strengthens the antimicrobial barrier function of the skin and boosts macrophage-driven host defense. Cell Metab 21(3):493-501. [PubMed: 25738463]  [MGI Ref ID J:220700]

Jenne CN; Enders A; Rivera R; Watson SR; Bankovich AJ; Pereira JP; Xu Y; Roots CM; Beilke JN; Banerjee A; Reiner SL; Miller SA; Weinmann AS; Goodnow CC; Lanier LL; Cyster JG; Chun J. 2009. T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow. J Exp Med 206(11):2469-81. [PubMed: 19808259]  [MGI Ref ID J:154069]

Jeong HW; Kim JH; Kim JY; Ha SJ; Kong YY. 2012. Mind bomb-1 in dendritic cells is specifically required for Notch-mediated T helper type 2 differentiation. PLoS One 7(4):e36359. [PubMed: 22558446]  [MGI Ref ID J:187271]

Jesenberger V; Procyk KJ; Ruth J; Schreiber M; Theussl HC; Wagner EF; Baccarini M. 2001. Protective role of Raf-1 in Salmonella-induced macrophage apoptosis. J Exp Med 193(3):353-64. [PubMed: 11157055]  [MGI Ref ID J:93687]

Juarez JG; Harun N; Thien M; Welschinger R; Baraz R; Pena AD; Pitson SM; Rettig M; DiPersio JF; Bradstock KF; Bendall LJ. 2012. Sphingosine-1-phosphate facilitates trafficking of hematopoietic stem cells and their mobilization by CXCR4 antagonists in mice. Blood 119(3):707-16. [PubMed: 22049516]  [MGI Ref ID J:181661]

Jude CD; Climer L; Xu D; Artinger E; Fisher JK; Ernst P. 2007. Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors. Cell Stem Cell 1(3):324-37. [PubMed: 18371366]  [MGI Ref ID J:147265]

Jurado S; Gleeson K; O'Donnell K; Izon DJ; Walkley CR; Strasser A; Tarlinton DM; Heierhorst J. 2012. The Zinc-finger protein ASCIZ regulates B cell development via DYNLL1 and Bim. J Exp Med 209(9):1629-39. [PubMed: 22891272]  [MGI Ref ID J:191832]

Jurczak MJ; Lee AH; Jornayvaz FR; Lee HY; Birkenfeld AL; Guigni BA; Kahn M; Samuel VT; Glimcher LH; Shulman GI. 2012. Dissociation of inositol-requiring enzyme (IRE1alpha)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice. J Biol Chem 287(4):2558-67. [PubMed: 22128176]  [MGI Ref ID J:181385]

Kalaitzidis D; Sykes SM; Wang Z; Punt N; Tang Y; Ragu C; Sinha AU; Lane SW; Souza AL; Clish CB; Anastasiou D; Gilliland DG; Scadden DT; Guertin DA; Armstrong SA. 2012. mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis. Cell Stem Cell 11(3):429-39. [PubMed: 22958934]  [MGI Ref ID J:193428]

Kalaszczynska I; Geng Y; Iino T; Mizuno S; Choi Y; Kondratiuk I; Silver DP; Wolgemuth DJ; Akashi K; Sicinski P. 2009. Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells. Cell 138(2):352-65. [PubMed: 19592082]  [MGI Ref ID J:155178]

Kalfa TA; Pushkaran S; Zhang X; Johnson JF; Pan D; Daria D; Geiger H; Cancelas JA; Williams DA; Zheng Y. 2010. Rac1 and Rac2 GTPases are necessary for early erythropoietic expansion in the bone marrow but not in the spleen. Haematologica 95(1):27-35. [PubMed: 20065081]  [MGI Ref ID J:162051]

Kamata T; Dankort D; Kang J; Giblett S; Pritchard CA; McMahon M; Leavitt AD. 2013. Hematopoietic expression of oncogenic BRAF promotes aberrant growth of monocyte-lineage cells resistant to PLX4720. Mol Cancer Res 11(12):1530-41. [PubMed: 24152792]  [MGI Ref ID J:206521]

Kamezaki K; Shimoda K; Numata A; Haro T; Kakumitsu H; Yoshie M; Yamamoto M; Takeda K; Matsuda T; Akira S; Ogawa K; Harada M. 2005. Roles of Stat3 and ERK in G-CSF signaling. Stem Cells 23(2):252-63. [PubMed: 15671148]  [MGI Ref ID J:110076]

Kang TB; Ben-Moshe T; Varfolomeev EE; Pewzner-Jung Y; Yogev N; Jurewicz A; Waisman A; Brenner O; Haffner R; Gustafsson E; Ramakrishnan P; Lapidot T; Wallach D. 2004. Caspase-8 serves both apoptotic and nonapoptotic roles. J Immunol 173(5):2976-84. [PubMed: 15322156]  [MGI Ref ID J:92722]

Karlsson G; Blank U; Moody JL; Ehinger M; Singbrant S; Deng CX; Karlsson S. 2007. Smad4 is critical for self-renewal of hematopoietic stem cells. J Exp Med 204(3):467-74. [PubMed: 17353364]  [MGI Ref ID J:125357]

Kato Y; Iwama A; Tadokoro Y; Shimoda K; Minoguchi M; Akira S; Tanaka M; Miyajima A; Kitamura T; Nakauchi H. 2005. Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis. J Exp Med 202(1):169-79. [PubMed: 15998795]  [MGI Ref ID J:100628]

Katzerke C; Madan V; Gerloff D; Brauer-Hartmann D; Hartmann JU; Wurm AA; Muller-Tidow C; Schnittger S; Tenen DG; Niederwieser D; Behre G. 2013. Transcription factor C/EBPalpha-induced microRNA-30c inactivates Notch1 during granulopoiesis and is downregulated in acute myeloid leukemia. Blood 122(14):2433-42. [PubMed: 23974200]  [MGI Ref ID J:203439]

Kawagoe H; Grosveld GC. 2005. MN1-TEL myeloid oncoprotein expressed in multipotent progenitors perturbs both myeloid and lymphoid growth and causes T-lymphoid tumors in mice. Blood 106(13):4278-86. [PubMed: 16081688]  [MGI Ref ID J:106800]

Kawane K; Ohtani M; Miwa K; Kizawa T; Kanbara Y; Yoshioka Y; Yoshikawa H; Nagata S. 2006. Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages. Nature 443(7114):998-1002. [PubMed: 17066036]  [MGI Ref ID J:114982]

Kawane K; Tanaka H; Kitahara Y; Shimaoka S; Nagata S. 2010. Cytokine-dependent but acquired immunity-independent arthritis caused by DNA escaped from degradation. Proc Natl Acad Sci U S A 107(45):19432-7. [PubMed: 20974942]  [MGI Ref ID J:167378]

Kawatani Y; Suzuki T; Shimizu R; Kelly VP; Yamamoto M. 2011. Nrf2 and selenoproteins are essential for maintaining oxidative homeostasis in erythrocytes and protecting against hemolytic anemia. Blood 117(3):986-96. [PubMed: 20978266]  [MGI Ref ID J:168404]

Kawelke N; Vasel M; Sens C; Au A; Dooley S; Nakchbandi IA. 2011. Fibronectin protects from excessive liver fibrosis by modulating the availability of and responsiveness of stellate cells to active TGF-beta. PLoS One 6(11):e28181. [PubMed: 22140539]  [MGI Ref ID J:181129]

Keel SB; Doty RT; Yang Z; Quigley JG; Chen J; Knoblaugh S; Kingsley PD; De Domenico I; Vaughn MB; Kaplan J; Palis J; Abkowitz JL. 2008. A heme export protein is required for red blood cell differentiation and iron homeostasis. Science 319(5864):825-8. [PubMed: 18258918]  [MGI Ref ID J:132057]

Keel SB; Phelps S; Sabo KM; O'Leary MN; Kirn-Safran CB; Abkowitz JL. 2012. Establishing Rps6 hemizygous mice as a model for studying how ribosomal protein haploinsufficiency impairs erythropoiesis. Exp Hematol 40(4):290-4. [PubMed: 22198155]  [MGI Ref ID J:191502]

Kemp R; Ireland H; Clayton E; Houghton C; Howard L; Winton DJ. 2004. Elimination of background recombination: somatic induction of Cre by combined transcriptional regulation and hormone binding affinity. Nucleic Acids Res 32(11):e92. [PubMed: 15247325]  [MGI Ref ID J:143936]

Kent DG; Li J; Tanna H; Fink J; Kirschner K; Pask DC; Silber Y; Hamilton TL; Sneade R; Simons BD; Green AR. 2013. Self-renewal of single mouse hematopoietic stem cells is reduced by JAK2V617F without compromising progenitor cell expansion. PLoS Biol 11(6):e1001576. [PubMed: 23750118]  [MGI Ref ID J:201427]

Keren Z; Naor S; Nussbaum S; Golan K; Itkin T; Sasaki Y; Schmidt-Supprian M; Lapidot T; Melamed D. 2011. B-cell depletion reactivates B lymphopoiesis in the BM and rejuvenates the B lineage in aging. Blood 117(11):3104-12. [PubMed: 21228330]  [MGI Ref ID J:170519]

Kerenyi MA; Shao Z; Hsu YJ; Guo G; Luc S; O'Brien K; Fujiwara Y; Peng C; Nguyen M; Orkin SH. 2013. Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation. Elife 2:e00633. [PubMed: 23795291]  [MGI Ref ID J:201572]

Khandanpour C; Krongold J; Schutte J; Bouwman F; Vassen L; Gaudreau MC; Chen R; Calero-Nieto FJ; Diamanti E; Hannah R; Meyer SE; Grimes HL; van der Reijden BA; Jansen JH; Patel CV; Peeters JK; Lowenberg B; Duhrsen U; Gottgens B; Moroy T. 2012. The human GFI136N variant induces epigenetic changes at the Hoxa9 locus and accelerates K-RAS driven myeloproliferative disorder in mice. Blood 120(19):4006-17. [PubMed: 22932805]  [MGI Ref ID J:192927]

Khandanpour C; Phelan JD; Vassen L; Schutte J; Chen R; Horman SR; Gaudreau MC; Krongold J; Zhu J; Paul WE; Duhrsen U; Gottgens B; Grimes HL; Moroy T. 2013. Growth factor independence 1 antagonizes a p53-induced DNA damage response pathway in lymphoblastic leukemia. Cancer Cell 23(2):200-14. [PubMed: 23410974]  [MGI Ref ID J:194309]

Khandanpour C; Sharif-Askari E; Vassen L; Gaudreau MC; Zhu J; Paul WE; Okayama T; Kosan C; Moroy T. 2010. Evidence that growth factor independence 1b regulates dormancy and peripheral blood mobilization of hematopoietic stem cells. Blood 116(24):5149-61. [PubMed: 20826720]  [MGI Ref ID J:167416]

Kim A; Morgan K; Hasz DE; Wiesner SM; Lauchle JO; Geurts JL; Diers MD; Le DT; Kogan SC; Parada LF; Shannon K; Largaespada DA. 2007. Beta common receptor inactivation attenuates myeloproliferative disease in Nf1 mutant mice. Blood 109(4):1687-91. [PubMed: 17090653]  [MGI Ref ID J:123850]

Kim I; Saunders TL; Morrison SJ. 2007. Sox17 dependence distingushes the transcriptional regulation of fetal from adult hematopoietic stem cells Cell 130(3):470-83. [PubMed: 17655922]  [MGI Ref ID J:123050]

Kim IM; Ackerson T; Ramakrishna S; Tretiakova M; Wang IC; Kalin TV; Major ML; Gusarova GA; Yoder HM; Costa RH; Kalinichenko VV. 2006. The Forkhead Box m1 transcription factor stimulates the proliferation of tumor cells during development of lung cancer. Cancer Res 66(4):2153-61. [PubMed: 16489016]  [MGI Ref ID J:106651]

Kim JH; Thimmulappa RK; Kumar V; Cui W; Kumar S; Kombairaju P; Zhang H; Margolick J; Matsui W; Macvittie T; Malhotra SV; Biswal S. 2014. NRF2-mediated Notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation. J Clin Invest 124(2):730-41. [PubMed: 24463449]  [MGI Ref ID J:208444]

Kim YW; Koo BK; Jeong HW; Yoon MJ; Song R; Shin J; Jeong DC; Kim SH; Kong YY. 2008. Defective Notch activation in microenvironment leads to myeloproliferative disease. Blood 112(12):4628-38. [PubMed: 18818392]  [MGI Ref ID J:143346]

Kimura A; Rieger MA; Simone JM; Chen W; Wickre MC; Zhu BM; Hoppe PS; O'Shea JJ; Schroeder T; Hennighausen L. 2009. The transcription factors STAT5A/B regulate GM-CSF-mediated granulopoiesis. Blood 114(21):4721-8. [PubMed: 19779039]  [MGI Ref ID J:155489]

King B; Trimarchi T; Reavie L; Xu L; Mullenders J; Ntziachristos P; Aranda-Orgilles B; Perez-Garcia A; Shi J; Vakoc C; Sandy P; Shen SS; Ferrando A; Aifantis I. 2013. The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability. Cell 153(7):1552-66. [PubMed: 23791182]  [MGI Ref ID J:200006]

Kipp AP; Muller MF; Goken EM; Deubel S; Brigelius-Flohe R. 2012. The selenoproteins GPx2, TrxR2 and TrxR3 are regulated by Wnt signalling in the intestinal epithelium. Biochim Biophys Acta 1820(10):1588-96. [PubMed: 22683372]  [MGI Ref ID J:188063]

Kirstetter P; Anderson K; Porse BT; Jacobsen SE; Nerlov C. 2006. Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block. Nat Immunol 7(10):1048-56. [PubMed: 16951689]  [MGI Ref ID J:112660]

Kistler M; Even A; Wagner S; Becker C; Darshan D; Vanoaica L; Kuhn LC; Schumann K. 2014. 59Fe-distribution in conditional ferritin-H-deleted mice. Exp Hematol 42(1):59-69. [PubMed: 24141093]  [MGI Ref ID J:215731]

Klinakis A; Lobry C; Abdel-Wahab O; Oh P; Haeno H; Buonamici S; van De Walle I; Cathelin S; Trimarchi T; Araldi E; Liu C; Ibrahim S; Beran M; Zavadil J; Efstratiadis A; Taghon T; Michor F; Levine RL; Aifantis I. 2011. A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia. Nature 473(7346):230-3. [PubMed: 21562564]  [MGI Ref ID J:172442]

Knutson SK; Chyla BJ; Amann JM; Bhaskara S; Huppert SS; Hiebert SW. 2008. Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks. EMBO J 27(7):1017-28. [PubMed: 18354499]  [MGI Ref ID J:134288]

Kobayashi E; Shimizu R; Kikuchi Y; Takahashi S; Yamamoto M. 2010. Loss of the Gata1 gene IE exon leads to variant transcript expression and the production of a GATA1 protein lacking the N-terminal domain. J Biol Chem 285(1):773-83. [PubMed: 19854837]  [MGI Ref ID J:158194]

Koch U; Fiorini E; Benedito R; Besseyrias V; Schuster-Gossler K; Pierres M; Manley NR; Duarte A; Macdonald HR; Radtke F. 2008. Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment. J Exp Med 205(11):2515-23. [PubMed: 18824585]  [MGI Ref ID J:143472]

Koch U; Wilson A; Cobas M; Kemler R; Macdonald HR; Radtke F. 2008. Simultaneous loss of beta- and gamma-catenin does not perturb hematopoiesis or lymphopoiesis. Blood 111(1):160-4. [PubMed: 17855627]  [MGI Ref ID J:129952]

Kohara H; Omatsu Y; Sugiyama T; Noda M; Fujii N; Nagasawa T. 2007. Development of plasmacytoid dendritic cells in bone marrow stromal cell niches requires CXCL12-CXCR4 chemokine signaling. Blood 110(13):4153-60. [PubMed: 17827391]  [MGI Ref ID J:149096]

Komatsu M; Kurokawa H; Waguri S; Taguchi K; Kobayashi A; Ichimura Y; Sou YS; Ueno I; Sakamoto A; Tong KI; Kim M; Nishito Y; Iemura S; Natsume T; Ueno T; Kominami E; Motohashi H; Tanaka K; Yamamoto M. 2010. The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat Cell Biol 12(3):213-23. [PubMed: 20173742]  [MGI Ref ID J:172945]

Komatsu M; Waguri S; Koike M; Sou YS; Ueno T; Hara T; Mizushima N; Iwata J; Ezaki J; Murata S; Hamazaki J; Nishito Y; Iemura S; Natsume T; Yanagawa T; Uwayama J; Warabi E; Yoshida H; Ishii T; Kobayashi A; Yamamoto M; Yue Z; Uchiyama Y; Kominami E; TanakaK. 2007. Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell 131(6):1149-63. [PubMed: 18083104]  [MGI Ref ID J:130839]

Komatsu M; Waguri S; Ueno T; Iwata J; Murata S; Tanida I; Ezaki J; Mizushima N; Ohsumi Y; Uchiyama Y; Kominami E; Tanaka K; Chiba T. 2005. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 169(3):425-34. [PubMed: 15866887]  [MGI Ref ID J:100199]

Kong G; Wunderlich M; Yang D; Ranheim EA; Young KH; Wang J; Chang YI; Du J; Liu Y; Tey SR; Zhang X; Juckett M; Mattison R; Damnernsawad A; Zhang J; Mulloy JC; Zhang J. 2014. Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm. J Clin Invest 124(6):2762-73. [PubMed: 24812670]  [MGI Ref ID J:212912]

Kono M; Tucker AE; Tran J; Bergner JB; Turner EM; Proia RL. 2014. Sphingosine-1-phosphate receptor 1 reporter mice reveal receptor activation sites in vivo. J Clin Invest 124(5):2076-86. [PubMed: 24667638]  [MGI Ref ID J:212772]

Kortylewski M; Kujawski M; Herrmann A; Yang C; Wang L; Liu Y; Salcedo R; Yu H. 2009. Toll-like receptor 9 activation of signal transducer and activator of transcription 3 constrains its agonist-based immunotherapy. Cancer Res 69(6):2497-505. [PubMed: 19258507]  [MGI Ref ID J:146884]

Kortylewski M; Kujawski M; Wang T; Wei S; Zhang S; Pilon-Thomas S; Niu G; Kay H; Mule J; Kerr WG; Jove R; Pardoll D; Yu H. 2005. Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity. Nat Med 11(12):1314-21. [PubMed: 16288283]  [MGI Ref ID J:104133]

Kortylewski M; Xin H; Kujawski M; Lee H; Liu Y; Harris T; Drake C; Pardoll D; Yu H. 2009. Regulation of the IL-23 and IL-12 balance by Stat3 signaling in the tumor microenvironment. Cancer Cell 15(2):114-23. [PubMed: 19185846]  [MGI Ref ID J:144812]

Kranc KR; Schepers H; Rodrigues NP; Bamforth S; Villadsen E; Ferry H; Bouriez-Jones T; Sigvardsson M; Bhattacharya S; Jacobsen SE; Enver T. 2009. Cited2 is an essential regulator of adult hematopoietic stem cells. Cell Stem Cell 5(6):659-65. [PubMed: 19951693]  [MGI Ref ID J:155878]

Krasteva V; Buscarlet M; Diaz-Tellez A; Bernard MA; Crabtree GR; Lessard JA. 2012. The BAF53a subunit of SWI/SNF-like BAF complexes is essential for hemopoietic stem cell function. Blood 120(24):4720-32. [PubMed: 23018638]  [MGI Ref ID J:192124]

Kraus M; Alimzhanov MB; Rajewsky N; Rajewsky K. 2004. Survival of resting mature B lymphocytes depends on BCR signaling via the Igalpha/beta heterodimer. Cell 117(6):787-800. [PubMed: 15186779]  [MGI Ref ID J:91091]

Krivtsov AV; Feng Z; Lemieux ME; Faber J; Vempati S; Sinha AU; Xia X; Jesneck J; Bracken AP; Silverman LB; Kutok JL; Kung AL; Armstrong SA. 2008. H3K79 methylation profiles define murine and human MLL-AF4 leukemias. Cancer Cell 14(5):355-68. [PubMed: 18977325]  [MGI Ref ID J:140628]

Kroy DC; Hebing L; Sander LE; Gassler N; Erschfeld S; Sackett S; Galm O; Trautwein C; Streetz KL. 2012. Differential role of gp130-dependent STAT and Ras signalling for haematopoiesis following bone-marrow transplantation. PLoS One 7(6):e39728. [PubMed: 22745821]  [MGI Ref ID J:187931]

Kruger M; Moser M; Ussar S; Thievessen I; Luber CA; Forner F; Schmidt S; Zanivan S; Fassler R; Mann M. 2008. SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function. Cell 134(2):353-64. [PubMed: 18662549]  [MGI Ref ID J:145476]

Ku CJ; Hosoya T; Maillard I; Engel JD. 2012. GATA-3 regulates hematopoietic stem cell maintenance and cell-cycle entry. Blood 119(10):2242-51. [PubMed: 22267605]  [MGI Ref ID J:182538]

Kubovcakova L; Lundberg P; Grisouard J; Hao-Shen H; Romanet V; Andraos R; Murakami M; Dirnhofer S; Wagner KU; Radimerski T; Skoda RC. 2013. Differential effects of hydroxyurea and INC424 on mutant allele burden and myeloproliferative phenotype in a JAK2-V617F polycythemia vera mouse model. Blood 121(7):1188-99. [PubMed: 23264594]  [MGI Ref ID J:194600]

Kudo T; Sato T; Hagiwara K; Kozuma Y; Yamaguchi T; Ikehara Y; Hamada M; Matsumoto K; Ema M; Murata S; Ohkohchi N; Narimatsu H; Takahashi S. 2013. C1galt1-deficient mice exhibit thrombocytopenia due to abnormal terminal differentiation of megakaryocytes. Blood 122(9):1649-57. [PubMed: 23794065]  [MGI Ref ID J:202276]

Kuhn R; Schwenk F; Aguet M; Rajewsky K. 1995. Inducible gene targeting in mice. Science 269(5229):1427-9. [PubMed: 7660125]  [MGI Ref ID J:67927]

Kuijpers MJ; Schulte V; Bergmeier W; Lindhout T; Brakebusch C; Offermanns S; Fassler R; Heemskerk JW; Nieswandt B. 2003. Complementary roles of glycoprotein VI and alpha2beta1 integrin in collagen-induced thrombus formation in flowing whole blood ex vivo. FASEB J 17(6):685-7. [PubMed: 12586747]  [MGI Ref ID J:118488]

Kujawski M; Kortylewski M; Lee H; Herrmann A; Kay H; Yu H. 2008. Stat3 mediates myeloid cell-dependent tumor angiogenesis in mice. J Clin Invest 118(10):3367-77. [PubMed: 18776941]  [MGI Ref ID J:141140]

Kumar S; Xu J; Perkins C; Guo F; Snapper S; Finkelman FD; Zheng Y; Filippi MD. 2012. Cdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubules. Blood 120(17):3563-74. [PubMed: 22932798]  [MGI Ref ID J:192929]

Kuo YH; Gerstein RM; Castilla LH. 2008. Cbf{beta}-SMMHC impairs differentiation of common lymphoid progenitors and reveals an essential role for RUNX in early B-cell development. Blood 111(3):1543-51. [PubMed: 17940206]  [MGI Ref ID J:130688]

Kuo YH; Landrette SF; Heilman SA; Perrat PN; Garrett L; Liu PP; Le Beau MM; Kogan SC; Castilla LH. 2006. Cbf beta-SMMHC induces distinct abnormal myeloid progenitors able to develop acute myeloid leukemia. Cancer Cell 9(1):57-68. [PubMed: 16413472]  [MGI Ref ID J:105040]

Kuo YH; Zaidi SK; Gornostaeva S; Komori T; Stein GS; Castilla LH. 2009. Runx2 induces acute myeloid leukemia in cooperation with Cbfbeta-SMMHC in mice. Blood 113(14):3323-32. [PubMed: 19179305]  [MGI Ref ID J:148126]

Kusy S; Gault N; Ferri F; Lewandowski D; Barroca V; Jaracz-Ros A; Losson R; Romeo PH. 2011. Adult Hematopoiesis is Regulated by TIF1gamma, a Repressor of TAL1 and PU.1 Transcriptional Activity. Cell Stem Cell 8(4):412-25. [PubMed: 21474105]  [MGI Ref ID J:171356]

Kwon SM; Eguchi M; Wada M; Iwami Y; Hozumi K; Iwaguro H; Masuda H; Kawamoto A; Asahara T. 2008. Specific Jagged-1 signal from bone marrow microenvironment is required for endothelial progenitor cell development for neovascularization. Circulation 118(2):157-65. [PubMed: 18591437]  [MGI Ref ID J:155665]

Lai JC; Ponti S; Pan D; Kohler H; Skoda RC; Matthias P; Nagamine Y. 2012. The DEAH-box helicase RHAU is an essential gene and critical for mouse hematopoiesis. Blood 119(18):4291-300. [PubMed: 22422825]  [MGI Ref ID J:185179]

Lam K; Muselman A; Du R; Harada Y; Scholl AG; Yan M; Matsuura S; Weng S; Harada H; Zhang DE. 2014. Hmga2 is a direct target gene of RUNX1 and regulates expansion of myeloid progenitors in mice. Blood 124(14):2203-12. [PubMed: 25150295]  [MGI Ref ID J:218706]

Lam KP; Kuhn R; Rajewsky K. 1997. In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell 90(6):1073-83. [PubMed: 9323135]  [MGI Ref ID J:79299]

Lammermann T; Bader BL; Monkley SJ; Worbs T; Wedlich-Soldner R; Hirsch K; Keller M; Forster R; Critchley DR; Fassler R; Sixt M. 2008. Rapid leukocyte migration by integrin-independent flowing and squeezing. Nature 453(7191):51-5. [PubMed: 18451854]  [MGI Ref ID J:134784]

Lammermann T; Renkawitz J; Wu X; Hirsch K; Brakebusch C; Sixt M. 2009. Cdc42-dependent leading edge coordination is essential for interstitial dendritic cell migration. Blood 113(23):5703-10. [PubMed: 19190242]  [MGI Ref ID J:149380]

Lamsoul I; Metais A; Gouot E; Heuze ML; Lennon-Dumenil AM; Moog-Lutz C; Lutz PG. 2013. ASB2alpha regulates migration of immature dendritic cells. Blood 122(4):533-41. [PubMed: 23632887]  [MGI Ref ID J:200966]

Lan YY; Londono D; Bouley R; Rooney MS; Hacohen N. 2014. Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagy. Cell Rep 9(1):180-92. [PubMed: 25284779]  [MGI Ref ID J:218543]

Landrette SF; Kuo YH; Hensen K; Barjesteh van Waalwijk van Doorn-Khosrovani S; Perrat PN; Van de Ven WJ; Delwel R; Castilla LH. 2005. Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11. Blood 105(7):2900-7. [PubMed: 15585652]  [MGI Ref ID J:98443]

Larsson J; Blank U; Helgadottir H; Bjornsson JM; Ehinger M; Goumans MJ; Fan X; Leveen P; Karlsson S. 2003. TGF-beta signaling-deficient hematopoietic stem cells have normal self-renewal and regenerative ability in vivo despite increased proliferative capacity in vitro. Blood 102(9):3129-35. [PubMed: 12842983]  [MGI Ref ID J:86262]

Larsson J; Blank U; Klintman J; Magnusson M; Karlsson S. 2005. Quiescence of hematopoietic stem cells and maintenance of the stem cell pool is not dependent on TGF-beta signaling in vivo. Exp Hematol 33(5):592-6. [PubMed: 15850837]  [MGI Ref ID J:105140]

Larsson J; Ohishi M; Garrison B; Aspling M; Janzen V; Adams GB; Curto M; McClatchey AI; Schipani E; Scadden DT. 2008. Nf2/merlin regulates hematopoietic stem cell behavior by altering microenvironmental architecture. Cell Stem Cell 3(2):221-7. [PubMed: 18682243]  [MGI Ref ID J:149793]

Larsson SL; Skogsberg J; Bjorkegren J. 2004. The low density lipoprotein receptor prevents secretion of dense apoB100-containing lipoproteins from the liver. J Biol Chem 279(2):831-6. [PubMed: 14583618]  [MGI Ref ID J:124544]

Lassen LB; Fuchtbauer A; Schmitz A; Sorensen AB; Pedersen FS; Fuchtbauer EM. 2013. Septin9 is involved in T-cell development and CD8+ T-cell homeostasis. Cell Tissue Res 352(3):695-705. [PubMed: 23644740]  [MGI Ref ID J:205027]

Lauchle JO; Kim D; Le DT; Akagi K; Crone M; Krisman K; Warner K; Bonifas JM; Li Q; Coakley KM; Diaz-Flores E; Gorman M; Przybranowski S; Tran M; Kogan SC; Roose JP; Copeland NG; Jenkins NA; Parada L; Wolff L; Sebolt-Leopold J; Shannon K. 2009. Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras. Nature 461(7262):411-4. [PubMed: 19727076]  [MGI Ref ID J:152381]

Laurenti E; Varnum-Finney B; Wilson A; Ferrero I; Blanco-Bose WE; Ehninger A; Knoepfler PS; Cheng PF; MacDonald HR; Eisenman RN; Bernstein ID; Trumpp A. 2008. Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity. Cell Stem Cell 3(6):611-24. [PubMed: 19041778]  [MGI Ref ID J:149864]

Lazorchak AS; Wojciechowski J; Dai M; Zhuang Y. 2006. E2A promotes the survival of precursor and mature B lymphocytes. J Immunol 177(4):2495-504. [PubMed: 16888011]  [MGI Ref ID J:138355]

Lazzerini Denchi E; Celli G; de Lange T. 2006. Hepatocytes with extensive telomere deprotection and fusion remain viable and regenerate liver mass through endoreduplication. Genes Dev 20(19):2648-53. [PubMed: 17015429]  [MGI Ref ID J:112957]

Le DT; Kong N; Zhu Y; Lauchle JO; Aiyigari A; Braun BS; Wang E; Kogan SC; Le Beau MM; Parada L; Shannon KM. 2004. Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder. Blood 103(11):4243-50. [PubMed: 14982883]  [MGI Ref ID J:90973]

Lee AH; Scapa EF; Cohen DE; Glimcher LH. 2008. Regulation of hepatic lipogenesis by the transcription factor XBP1. Science 320(5882):1492-6. [PubMed: 18556558]  [MGI Ref ID J:137188]

Lee CK; Raz R; Gimeno R; Gertner R; Wistinghausen B; Takeshita K; DePinho RA; Levy DE. 2002. STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation. Immunity 17(1):63-72. [PubMed: 12150892]  [MGI Ref ID J:78088]

Lee D; Kim T; Lim DS. 2011. The Er71 is an important regulator of hematopoietic stem cells in adult mice. Stem Cells 29(3):539-48. [PubMed: 21425416]  [MGI Ref ID J:172687]

Lee H; Herrmann A; Deng JH; Kujawski M; Niu G; Li Z; Forman S; Jove R; Pardoll DM; Yu H. 2009. Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors. Cancer Cell 15(4):283-93. [PubMed: 19345327]  [MGI Ref ID J:147435]

Lee JY; Nakada D; Yilmaz OH; Tothova Z; Joseph NM; Lim MS; Gilliland DG; Morrison SJ. 2010. mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion. Cell Stem Cell 7(5):593-605. [PubMed: 21040901]  [MGI Ref ID J:167537]

Lee SU; Maeda M; Ishikawa Y; Li SM; Wilson A; Jubb AM; Sakurai N; Weng L; Fiorini E; Radtke F; Yan M; Macdonald HR; Chen CC; Maeda T. 2013. LRF-mediated Dll4 repression in erythroblasts is necessary for hematopoietic stem cell maintenance. Blood 121(6):918-29. [PubMed: 23134786]  [MGI Ref ID J:194639]

Lefort CT; Rossaint J; Moser M; Petrich BG; Zarbock A; Monkley SJ; Critchley DR; Ginsberg MH; Fassler R; Ley K. 2012. Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation. Blood 119(18):4275-82. [PubMed: 22431571]  [MGI Ref ID J:185175]

Lei Y; Ripen AM; Ishimaru N; Ohigashi I; Nagasawa T; Jeker LT; Bosl MR; Hollander GA; Hayashi Y; Malefyt Rde W; Nitta T; Takahama Y. 2011. Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development. J Exp Med 208(2):383-94. [PubMed: 21300913]  [MGI Ref ID J:176844]

Lengner CJ; Camargo FD; Hochedlinger K; Welstead GG; Zaidi S; Gokhale S; Scholer HR; Tomilin A; Jaenisch R. 2007. Oct4 expression is not required for mouse somatic stem cell self-renewal. Cell Stem Cell 1(4):403-415. [PubMed: 18159219]  [MGI Ref ID J:130248]

Leuenroth SJ; Bencivenga N; Chahboune H; Hyder F; Crews CM. 2010. Triptolide reduces cyst formation in a neonatal to adult transition Pkd1 model of ADPKD. Nephrol Dial Transplant 25(7):2187-94. [PubMed: 20139063]  [MGI Ref ID J:168178]

Leuker CE; Labow M; Muller W; Wagner N. 2001. Neonatally induced inactivation of the vascular cell adhesion molecule 1 gene impairs b cell localization and t cell-dependent humoral immune response. J Exp Med 193(6):755-68. [PubMed: 11257141]  [MGI Ref ID J:68148]

Leung CG; Xu Y; Mularski B; Liu H; Gurbuxani S; Crispino JD. 2007. Requirements for survivin in terminal differentiation of erythroid cells and maintenance of hematopoietic stem and progenitor cells. J Exp Med 204(7):1603-11. [PubMed: 17576776]  [MGI Ref ID J:125872]

Levantini E; Lee S; Radomska HS; Hetherington CJ; Alberich-Jorda M; Amabile G; Zhang P; Gonzalez DA; Zhang J; Basseres DS; Wilson NK; Koschmieder S; Huang G; Zhang DE; Ebralidze AK; Bonifer C; Okuno Y; Gottgens B; Tenen DG. 2011. RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory element. EMBO J 30(19):4059-70. [PubMed: 21873977]  [MGI Ref ID J:179931]

Leveen P; Carlsen M; Makowska A; Oddsson S; Larsson J; Goumans MJ; Cilio CM; Karlsson S. 2005. TGF-beta type II receptor-deficient thymocytes develop normally but demonstrate increased CD8+ proliferation in vivo. Blood 106(13):4234-40. [PubMed: 16131565]  [MGI Ref ID J:124057]

Li BE; Gan T; Meyerson M; Rabbitts TH; Ernst P. 2013. Distinct pathways regulated by menin and by MLL1 in hematopoietic stem cells and developing B cells. Blood 122(12):2039-46. [PubMed: 23908472]  [MGI Ref ID J:202501]

Li H; Oliver T; Jia W; He YW. 2006. Efficient dendritic cell priming of T lymphocytes depends on the extracellular matrix protein mindin. EMBO J 25(17):4097-107. [PubMed: 16917498]  [MGI Ref ID J:112875]

Li J; Nanayakkara A; Jun J; Savransky V; Polotsky VY. 2007. Effect of deficiency in SREBP cleavage-activating protein on lipid metabolism during intermittent hypoxia. Physiol Genomics 31(2):273-80. [PubMed: 17666524]  [MGI Ref ID J:128622]

Li J; Spensberger D; Ahn JS; Anand S; Beer PA; Ghevaert C; Chen E; Forrai A; Scott LM; Ferreira R; Campbell PJ; Watson SP; Liu P; Erber WN; Huntly BJ; Ottersbach K; Green AR. 2010. JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia. Blood 116(9):1528-38. [PubMed: 20489053]  [MGI Ref ID J:164539]

Li L; Jothi R; Cui K; Lee JY; Cohen T; Gorivodsky M; Tzchori I; Zhao Y; Hayes SM; Bresnick EH; Zhao K; Westphal H; Love PE. 2011. Nuclear adaptor Ldb1 regulates a transcriptional program essential for the maintenance of hematopoietic stem cells. Nat Immunol 12(2):129-36. [PubMed: 21186366]  [MGI Ref ID J:170572]

Li L; Lee JY; Gross J; Song SH; Dean A; Love PE. 2010. A requirement for Lim domain binding protein 1 in erythropoiesis. J Exp Med 207(12):2543-50. [PubMed: 21041453]  [MGI Ref ID J:176875]

Li L; Piloto O; Nguyen HB; Greenberg K; Takamiya K; Racke F; Huso D; Small D. 2008. Knock-in of an internal tandem duplication mutation into murine FLT3 confers myeloproliferative disease in a mouse model. Blood 111(7):3849-58. [PubMed: 18245664]  [MGI Ref ID J:133528]

Li Q; Haigis KM; McDaniel A; Harding-Theobald E; Kogan SC; Akagi K; Wong JC; Braun BS; Wolff L; Jacks T; Shannon K. 2011. Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus. Blood 117(6):2022-32. [PubMed: 21163920]  [MGI Ref ID J:169608]

Li W; Hou Y; Ming M; Yu L; Seba A; Qian Z. 2013. Apc regulates the function of hematopoietic stem cells largely through beta-catenin-dependent mechanisms. Blood 121(20):4063-72. [PubMed: 23547052]  [MGI Ref ID J:198202]

Li X; Romain RD; Park D; Scadden DT; Merchant JL; Arnaout MA. 2014. Stress Hematopoiesis Is Regulated by the Kruppel-Like Transcription Factor ZBP-89. Stem Cells 32(3):791-801. [PubMed: 24549639]  [MGI Ref ID J:206932]

Liao W; Hui TY; Young SG; Davis RA. 2003. Blocking microsomal triglyceride transfer protein interferes with apoB secretion without causing retention or stress in the ER. J Lipid Res 44(5):978-85. [PubMed: 12588952]  [MGI Ref ID J:83459]

Lieu HD; Withycombe SK; Walker Q; Rong JX; Walzem RL; Wong JS; Hamilton RL; Fisher EA; Young SG. 2003. Eliminating atherogenesis in mice by switching off hepatic lipoprotein secretion. Circulation 107(9):1315-21. [PubMed: 12628954]  [MGI Ref ID J:91722]

Lieu YK; Reddy EP. 2009. Conditional c-myb knockout in adult hematopoietic stem cells leads to loss of self-renewal due to impaired proliferation and accelerated differentiation. Proc Natl Acad Sci U S A :. [PubMed: 19955420]  [MGI Ref ID J:155521]

Lindberg MK; Svensson J; Venken K; Chavoshi T; Andersson N; Moverare Skrtic S; Isaksson O; Vanderschueren D; Carlsten H; Ohlsson C. 2006. Liver-derived IGF-I is permissive for ovariectomy-induced trabecular bone loss. Bone 38(1):85-92. [PubMed: 16257281]  [MGI Ref ID J:123447]

Liu B; Zupan B; Laird E; Klein S; Gleason G; Bozinoski M; Gal Toth J; Toth M. 2014. Maternal hematopoietic TNF, via milk chemokines, programs hippocampal development and memory. Nat Neurosci 17(1):97-105. [PubMed: 24292233]  [MGI Ref ID J:207927]

Liu F; Lee JY; Wei H; Tanabe O; Engel JD; Morrison SJ; Guan JL. 2010. FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells. Blood 116(23):4806-14. [PubMed: 20716775]  [MGI Ref ID J:167258]

Liu H; Zhou J; Cheng P; Ramachandran I; Nefedova Y; Gabrilovich DI. 2013. Regulation of dendritic cell differentiation in bone marrow during emergency myelopoiesis. J Immunol 191(4):1916-26. [PubMed: 23833236]  [MGI Ref ID J:205705]

Liu J; Halene S; Yang M; Iqbal J; Yang R; Mehal WZ; Chuang WL; Jain D; Yuen T; Sun L; Zaidi M; Mistry PK. 2012. Gaucher disease gene GBA functions in immune regulation. Proc Natl Acad Sci U S A 109(25):10018-23. [PubMed: 22665763]  [MGI Ref ID J:185511]

Liu L; Li M; Spangler LC; Spear C; Veenstra M; Darnall L; Chang C; Cotleur AC; Ransohoff RM. 2013. Functional defect of peripheral neutrophils in mice with induced deletion of CXCR2. Genesis 51(8):587-95. [PubMed: 23650205]  [MGI Ref ID J:204482]

Liu L; Sanchez-Bonilla M; Crouthamel M; Giachelli C; Keel S. 2013. Mice lacking the sodium-dependent phosphate import protein, PiT1 (SLC20A1), have a severe defect in terminal erythroid differentiation and early B cell development. Exp Hematol 41(5):432-43.e7. [PubMed: 23376999]  [MGI Ref ID J:214922]

Lotinun S; Kiviranta R; Matsubara T; Alzate JA; Neff L; Luth A; Koskivirta I; Kleuser B; Vacher J; Vuorio E; Horne WC; Baron R. 2013. Osteoclast-specific cathepsin K deletion stimulates S1P-dependent bone formation. J Clin Invest :. [PubMed: 23321671]  [MGI Ref ID J:194492]

Lu J; Sun Y; Nombela-Arrieta C; Du KP; Park SY; Chai L; Walkley C; Luo HR; Silberstein LE. 2012. Fak depletion in both hematopoietic and nonhematopoietic niche cells leads to hematopoietic stem cell expansion. Exp Hematol 40(4):307-17.e3. [PubMed: 22155722]  [MGI Ref ID J:191529]

Lukin K; Fields S; Lopez D; Cherrier M; Ternyak K; Ramirez J; Feeney AJ; Hagman J. 2010. Compound haploinsufficiencies of Ebf1 and Runx1 genes impede B cell lineage progression. Proc Natl Acad Sci U S A 107(17):7869-74. [PubMed: 20385820]  [MGI Ref ID J:159374]

Luyten A; Su X; Gondela S; Chen Y; Rompani S; Takakura A; Zhou J. 2010. Aberrant regulation of planar cell polarity in polycystic kidney disease. J Am Soc Nephrol 21(9):1521-32. [PubMed: 20705705]  [MGI Ref ID J:185908]

Lyubynska N; Gorman MF; Lauchle JO; Hong WX; Akutagawa JK; Shannon K; Braun BS. 2011. A MEK Inhibitor Abrogates Myeloproliferative Disease in Kras Mutant Mice. Sci Transl Med 3(76):76ra27. [PubMed: 21451123]  [MGI Ref ID J:170811]

Maeda S; Kamata H; Luo JL; Leffert H; Karin M. 2005. IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 121(7):977-90. [PubMed: 15989949]  [MGI Ref ID J:115107]

Maeda T; Ito K; Merghoub T; Poliseno L; Hobbs RM; Wang G; Dong L; Maeda M; Dore LC; Zelent A; Luzzatto L; Teruya-Feldstein J; Weiss MJ; Pandolfi PP. 2009. LRF is an essential downstream target of GATA1 in erythroid development and regulates BIM-dependent apoptosis. Dev Cell 17(4):527-40. [PubMed: 19853566]  [MGI Ref ID J:154780]

Maeda T; Merghoub T; Hobbs RM; Dong L; Maeda M; Zakrzewski J; van den Brink MR; Zelent A; Shigematsu H; Akashi K; Teruya-Feldstein J; Cattoretti G; Pandolfi PP. 2007. Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF. Science 316(5826):860-6. [PubMed: 17495164]  [MGI Ref ID J:121576]

Magee JA; Ikenoue T; Nakada D; Lee JY; Guan KL; Morrison SJ. 2012. Temporal changes in PTEN and mTORC2 regulation of hematopoietic stem cell self-renewal and leukemia suppression. Cell Stem Cell 11(3):415-28. [PubMed: 22958933]  [MGI Ref ID J:191342]

Maillard I; Koch U; Dumortier A; Shestova O; Xu L; Sai H; Pross SE; Aster JC; Bhandoola A; Radtke F; Pear WS. 2008. Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cells. Cell Stem Cell 2(4):356-66. [PubMed: 18397755]  [MGI Ref ID J:149802]

Mali RS; Ma P; Zeng LF; Martin H; Ramdas B; He Y; Sims E; Nabinger S; Ghosh J; Sharma N; Munugalavadla V; Chatterjee A; Li S; Sandusky G; Craig AW; Bunting KD; Feng GS; Chan RJ; Zhang ZY; Kapur R. 2012. Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT. Blood 120(13):2669-78. [PubMed: 22806893]  [MGI Ref ID J:189153]

Malik G; Knowles LM; Dhir R; Xu S; Yang S; Ruoslahti E; Pilch J. 2010. Plasma fibronectin promotes lung metastasis by contributions to fibrin clots and tumor cell invasion. Cancer Res 70(11):4327-34. [PubMed: 20501851]  [MGI Ref ID J:160678]

Mancini A; Niemann-Seyde SC; Pankow R; El Bounkari O; Klebba-Farber S; Koch A; Jaworska E; Spooncer E; Gruber AD; Whetton AD; Tamura T. 2010. THOC5/FMIP, an mRNA export TREX complex protein, is essential for hematopoietic primitive cell survival in vivo. BMC Biol 8:1. [PubMed: 20051105]  [MGI Ref ID J:169944]

Mancini E; Sanjuan-Pla A; Luciani L; Moore S; Grover A; Zay A; Rasmussen KD; Luc S; Bilbao D; O'Carroll D; Jacobsen SE; Nerlov C. 2011. FOG-1 and GATA-1 act sequentially to specify definitive megakaryocytic and erythroid progenitors. EMBO J 31(2):351-65. [PubMed: 22068055]  [MGI Ref ID J:180160]

Mancini SJ; Mantei N; Dumortier A; Suter U; Macdonald HR; Radtke F. 2005. Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation. Blood 105(6):2340-2. [PubMed: 15550486]  [MGI Ref ID J:98129]

Mao X; Fujiwara Y; Chapdelaine A; Yang H; Orkin SH. 2001. Activation of EGFP expression by cre-mediated excision in a new ROSA26 reporter mouse strain Blood 97(1):324-6. [PubMed: 11133778]  [MGI Ref ID J:66742]

Maritano D; Sugrue ML; Tininini S; Dewilde S; Strobl B; Fu X; Murray-Tait V; Chiarle R; Poli V. 2004. The STAT3 isoforms alpha and beta have unique and specific functions. Nat Immunol 5(4):401-9. [PubMed: 15021879]  [MGI Ref ID J:89194]

Maruyama M; Lam KP; Rajewsky K. 2000. Memory B-cell persistence is independent of persisting immunizing antigen. Nature 407(6804):636-42. [PubMed: 11034213]  [MGI Ref ID J:111654]

Marx-Stoelting P; Borowiak M; Knorpp T; Birchmeier C; Buchmann A; Schwarz M. 2009. Hepatocarcinogenesis in mice with a conditional knockout of the hepatocyte growth factor receptor c-Met. Int J Cancer 124(8):1767-72. [PubMed: 19123478]  [MGI Ref ID J:147508]

Matsumoto A; Takeishi S; Kanie T; Susaki E; Onoyama I; Tateishi Y; Nakayama K; Nakayama KI. 2011. p57 Is Required for Quiescence and Maintenance of Adult Hematopoietic Stem Cells. Cell Stem Cell 9(3):262-71. [PubMed: 21885021]  [MGI Ref ID J:176209]

Matsumoto N; Ezaki J; Komatsu M; Takahashi K; Mineki R; Taka H; Kikkawa M; Fujimura T; Takeda-Ezaki M; Ueno T; Tanaka K; Kominami E. 2008. Comprehensive proteomics analysis of autophagy-deficient mouse liver. Biochem Biophys Res Commun 368(3):643-9. [PubMed: 18249191]  [MGI Ref ID J:132663]

Matsuoka S; Oike Y; Onoyama I; Iwama A; Arai F; Takubo K; Mashimo Y; Oguro H; Nitta E; Ito K; Miyamoto K; Yoshiwara H; Hosokawa K; Nakamura Y; Gomei Y; Iwasaki H; Hayashi Y; Matsuzaki Y; Nakayama K; Ikeda Y; Hata A; Chiba S; Nakayama KI; Suda T. 2008. Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL. Genes Dev 22(8):986-91. [PubMed: 18367647]  [MGI Ref ID J:133773]

Matsuura S; Komeno Y; Stevenson KE; Biggs JR; Lam K; Tang T; Lo MC; Cong X; Yan M; Neuberg DS; Zhang DE. 2012. Expression of the runt homology domain of RUNX1 disrupts homeostasis of hematopoietic stem cells and induces progression to myelodysplastic syndrome. Blood 120(19):4028-37. [PubMed: 22919028]  [MGI Ref ID J:192948]

McCarty OJ; Larson MK; Auger JM; Kalia N; Atkinson BT; Pearce AC; Ruf S; Henderson RB; Tybulewicz VL; Machesky LM; Watson SP. 2005. Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow. J Biol Chem 280(47):39474-84. [PubMed: 16195235]  [MGI Ref ID J:104107]

McCormack MP; Hall MA; Schoenwaelder SM; Zhao Q; Ellis S; Prentice JA; Clarke AJ; Slater NJ; Salmon JM; Jackson SP; Jane SM; Curtis DJ. 2006. A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis. Blood 108(7):2248-56. [PubMed: 16763211]  [MGI Ref ID J:139474]

McCormack MP; Shields BJ; Jackson JT; Nasa C; Shi W; Slater NJ; Tremblay CS; Rabbitts TH; Curtis DJ. 2013. Requirement for Lyl1 in a model of Lmo2-driven early T-cell precursor ALL. Blood 122(12):2093-103. [PubMed: 23926305]  [MGI Ref ID J:202496]

McCormack MP; Young LF; Vasudevan S; de Graaf CA; Codrington R; Rabbitts TH; Jane SM; Curtis DJ. 2010. The lmo2 oncogene initiates leukemia in mice by inducing thymocyte self-renewal. Science 327(5967):879-83. [PubMed: 20093438]  [MGI Ref ID J:156935]

McGowan KA; Pang WW; Bhardwaj R; Perez MG; Pluvinage JV; Glader BE; Malek R; Mendrysa SM; Weissman IL; Park CY; Barsh GS. 2011. Reduced ribosomal protein gene dosage and p53 activation in low-risk myelodysplastic syndrome. Blood 118(13):3622-33. [PubMed: 21788341]  [MGI Ref ID J:177077]

McMahan RS; Riehle KJ; Fausto N; Campbell JS. 2013. A disintegrin and metalloproteinase 17 regulates TNF and TNFR1 levels in inflammation and liver regeneration in mice. Am J Physiol Gastrointest Liver Physiol 305(1):G25-34. [PubMed: 23639813]  [MGI Ref ID J:202784]

Mead AJ; Kharazi S; Atkinson D; Macaulay I; Pecquet C; Loughran S; Lutteropp M; Woll P; Chowdhury O; Luc S; Buza-Vidas N; Ferry H; Clark SA; Goardon N; Vyas P; Constantinescu SN; Sitnicka E; Nerlov C; Jacobsen SE. 2013. FLT3-ITDs Instruct a Myeloid Differentiation and Transformation Bias in Lymphomyeloid Multipotent Progenitors. Cell Rep 3(6):1766-76. [PubMed: 23727242]  [MGI Ref ID J:199313]

Meinders M; Kulu DI; van de Werken HJ; Hoogenboezem M; Janssen H; Brouwer RW; van Ijcken WF; Rijkers EJ; Demmers JA; Kruger I; van den Berg TK; Suske G; Gutierrez L; Philipsen S. 2015. Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function. Blood 125(12):1957-67. [PubMed: 25538045]  [MGI Ref ID J:221503]

Melchers A; Stockl L; Radszewski J; Anders M; Krenzlin H; Kalischke C; Scholz R; Jordan A; Nebrich G; Klose J; Sperling K; Digweed M; Demuth I. 2009. A systematic proteomic study of irradiated DNA repair deficient Nbn-mice. PLoS ONE 4(5):e5423. [PubMed: 19412544]  [MGI Ref ID J:148891]

Mendrysa SM; McElwee MK; Michalowski J; O'Leary KA; Young KM; Perry ME. 2003. mdm2 Is Critical for Inhibition of p53 during Lymphopoiesis and the Response to Ionizing Irradiation. Mol Cell Biol 23(2):462-72. [PubMed: 12509446]  [MGI Ref ID J:81065]

Menendez-Gutierrez MP; Roszer T; Fuentes L; Nunez V; Escolano A; Redondo JM; De Clerck N; Metzger D; Valledor AF; Ricote M. 2015. Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling. J Clin Invest 125(2):809-23. [PubMed: 25574839]  [MGI Ref ID J:220393]

Mercer K; Giblett S; Green S; Lloyd D; Darocha Dias S; Plumb M; Marais R; Pritchard C. 2005. Expression of endogenous oncogenic V600EB-raf induces proliferation and developmental defects in mice and transformation of primary fibroblasts. Cancer Res 65(24):11493-500. [PubMed: 16357158]  [MGI Ref ID J:104375]

Metcalf D; Dakic A; Mifsud S; Di Rago L; Wu L; Nutt S. 2006. Inactivation of PU.1 in adult mice leads to the development of myeloid leukemia. Proc Natl Acad Sci U S A 103(5):1486-91. [PubMed: 16432184]  [MGI Ref ID J:105994]

Mikkola HK; Klintman J; Yang H; Hock H; Schlaeger TM; Fujiwara Y; Orkin SH. 2003. Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene. Nature 421(6922):547-51. [PubMed: 12540851]  [MGI Ref ID J:83215]

Miller JD; Chu Y; Castaneda LE; Serrano KM; Brooks RM; Heistad DD. 2013. Vascular function during prolonged progression and regression of atherosclerosis in mice. Arterioscler Thromb Vasc Biol 33(3):459-65. [PubMed: 23307875]  [MGI Ref ID J:216887]

Miller JD; Weiss RM; Serrano KM; Brooks RM 2nd; Berry CJ; Zimmerman K; Young SG; Heistad DD. 2009. Lowering plasma cholesterol levels halts progression of aortic valve disease in mice. Circulation 119(20):2693-701. [PubMed: 19433756]  [MGI Ref ID J:166428]

Miller JD; Weiss RM; Serrano KM; Castaneda LE; Brooks RM; Zimmerman K; Heistad DD. 2010. Evidence for active regulation of pro-osteogenic signaling in advanced aortic valve disease. Arterioscler Thromb Vasc Biol 30(12):2482-6. [PubMed: 20864669]  [MGI Ref ID J:183146]

Minehira-Castelli K; Leonard SW; Walker QM; Traber MG; Young SG. 2006. Absence of VLDL secretion does not affect alpha-tocopherol content in peripheral tissues. J Lipid Res 47(8):1733-8. [PubMed: 16710047]  [MGI Ref ID J:112587]

Mistry PK; Liu J; Sun L; Chuang WL; Yuen T; Yang R; Lu P; Zhang K; Li J; Keutzer J; Stachnik A; Mennone A; Boyer JL; Jain D; Brady RO; New MI; Zaidi M. 2014. Glucocerebrosidase 2 gene deletion rescues type 1 Gaucher disease. Proc Natl Acad Sci U S A 111(13):4934-9. [PubMed: 24639522]  [MGI Ref ID J:207369]

Mistry PK; Liu J; Yang M; Nottoli T; McGrath J; Jain D; Zhang K; Keutzer J; Chuang WL; Mehal WZ; Zhao H; Lin A; Mane S; Liu X; Peng YZ; Li JH; Agrawal M; Zhu LL; Blair HC; Robinson LJ; Iqbal J; Sun L; Zaidi M. 2010. Glucocerebrosidase gene-deficient mouse recapitulates Gaucher disease displaying cellular and molecular dysregulation beyond the macrophage. Proc Natl Acad Sci U S A 107(45):19473-8. [PubMed: 20962279]  [MGI Ref ID J:167081]

Moers A; Nieswandt B; Massberg S; Wettschureck N; Gruner S; Konrad I; Schulte V; Aktas B; Gratacap MP; Simon MI; Gawaz M; Offermanns S. 2003. G13 is an essential mediator of platelet activation in hemostasis and thrombosis. Nat Med 9(11):1418-22. [PubMed: 14528298]  [MGI Ref ID J:99597]

Moon JO; Welch TP; Gonzalez FJ; Copple BL. 2009. Reduced liver fibrosis in hypoxia-inducible factor-1alpha-deficient mice. Am J Physiol Gastrointest Liver Physiol 296(3):G582-92. [PubMed: 19136383]  [MGI Ref ID J:146542]

Moran-Crusio K; Reavie L; Shih A; Abdel-Wahab O; Ndiaye-Lobry D; Lobry C; Figueroa ME; Vasanthakumar A; Patel J; Zhao X; Perna F; Pandey S; Madzo J; Song C; Dai Q; He C; Ibrahim S; Beran M; Zavadil J; Nimer SD; Melnick A; Godley LA; Aifantis I; Levine RL. 2011. Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation. Cancer Cell 20(1):11-24. [PubMed: 21723200]  [MGI Ref ID J:174053]

Moriya K; Bae E; Honda K; Sakai K; Sakaguchi T; Tsujimoto I; Kamisoyama H; Keene DR; Sasaki T; Sakai T. 2011. A fibronectin-independent mechanism of collagen fibrillogenesis in adult liver remodeling. Gastroenterology 140(5):1653-63. [PubMed: 21320502]  [MGI Ref ID J:214945]

Moriya K; Sakai K; Yan MH; Sakai T. 2012. Fibronectin is essential for survival but is dispensable for proliferation of hepatocytes in acute liver injury in mice. Hepatology 56(1):311-21. [PubMed: 22318920]  [MGI Ref ID J:215864]

Morris ZS; McClatchey AI. 2009. Aberrant epithelial morphology and persistent epidermal growth factor receptor signaling in a mouse model of renal carcinoma. Proc Natl Acad Sci U S A 106(24):9767-72. [PubMed: 19487675]  [MGI Ref ID J:150071]

Moser M; Nieswandt B; Ussar S; Pozgajova M; Fassler R. 2008. Kindlin-3 is essential for integrin activation and platelet aggregation. Nat Med 14(3):325-30. [PubMed: 18278053]  [MGI Ref ID J:133659]

Muers MR; Sharpe JA; Garrick D; Sloane-Stanley J; Nolan PM; Hacker T; Wood WG; Higgs DR; Gibbons RJ. 2007. Defining the cause of skewed X-chromosome inactivation in X-linked mental retardation by use of a mouse model. Am J Hum Genet 80(6):1138-49. [PubMed: 17503331]  [MGI Ref ID J:128058]

Mullins ES; Kombrinck KW; Talmage KE; Shaw MA; Witte DP; Ullman JM; Degen SJ; Sun W; Flick MJ; Degen JL. 2009. Genetic elimination of prothrombin in adult mice is not compatible with survival and results in spontaneous hemorrhagic events in both heart and brain. Blood 113(3):696-704. [PubMed: 18927430]  [MGI Ref ID J:144572]

Mupo A; Celani L; Dovey O; Cooper JL; Grove C; Rad R; Sportoletti P; Falini B; Bradley A; Vassiliou GS. 2013. A powerful molecular synergy between mutant Nucleophosmin and Flt3-ITD drives acute myeloid leukemia in mice. Leukemia 27(9):1917-20. [PubMed: 23478666]  [MGI Ref ID J:200121]

Murakami S; Shimizu R; Romeo PH; Yamamoto M; Motohashi H. 2014. Keap1-Nrf2 system regulates cell fate determination of hematopoietic stem cells. Genes Cells 19(3):239-53. [PubMed: 24580727]  [MGI Ref ID J:215699]

Nabinger SC; Li XJ; Ramdas B; He Y; Zhang X; Zeng L; Richine B; Bowling JD; Fukuda S; Goenka S; Liu Z; Feng GS; Yu M; Sandusky GE; Boswell HS; Zhang ZY; Kapur R; Chan RJ. 2013. The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo. Leukemia 27(2):398-408. [PubMed: 23103841]  [MGI Ref ID J:193632]

Nagahama Y; Sone M; Chen X; Okada Y; Yamamoto M; Xin B; Matsuo Y; Komatsu M; Suzuki A; Enomoto K; Nishikawa Y. 2014. Contributions of hepatocytes and bile ductular cells in ductular reactions and remodeling of the biliary system after chronic liver injury. Am J Pathol 184(11):3001-12. [PubMed: 25193593]  [MGI Ref ID J:216376]

Nagamachi A; Nakata Y; Ueda T; Yamasaki N; Ebihara Y; Tsuji K; Honda Z; Takubo K; Suda T; Oda H; Inaba T; Honda H. 2014. Acquired deficiency of A20 results in rapid apoptosis, systemic inflammation, and abnormal hematopoietic stem cell function. PLoS One 9(1):e87425. [PubMed: 24498102]  [MGI Ref ID J:212681]

Nakada D; Oguro H; Levi BP; Ryan N; Kitano A; Saitoh Y; Takeichi M; Wendt GR; Morrison SJ. 2014. Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy. Nature 505(7484):555-8. [PubMed: 24451543]  [MGI Ref ID J:206862]

Nakada D; Saunders TL; Morrison SJ. 2010. Lkb1 regulates cell cycle and energy metabolism in hematopoietic stem cells Nature 468(7324):653-658. [PubMed: 21124450]  [MGI Ref ID J:165090]

Nakagawa M; Shimabe M; Watanabe-Okochi N; Arai S; Yoshimi A; Shinohara A; Nishimoto N; Kataoka K; Sato T; Kumano K; Nannya Y; Ichikawa M; Imai Y; Kurokawa M. 2011. AML1/RUNX1 functions as a cytoplasmic attenuator of NF-kappaB signaling in the repression of myeloid tumors. Blood 118(25):6626-37. [PubMed: 22021368]  [MGI Ref ID J:179069]

Nalapareddy P; Schungel S; Hong JY; Manns MP; Jaeschke H; Vogel A. 2009. The BH3-only protein bid does not mediate death-receptor-induced liver injury in obstructive cholestasis. Am J Pathol 175(3):1077-85. [PubMed: 19661444]  [MGI Ref ID J:152902]

Natarajan A; Wagner B; Sibilia M. 2007. The EGF receptor is required for efficient liver regeneration. Proc Natl Acad Sci U S A 104(43):17081-6. [PubMed: 17940036]  [MGI Ref ID J:125912]

Ng CE; Sinha A; Krivtsov A; Dias S; Chang J; Armstrong SA; Kalaitzidis D. 2014. KRas(G12D)-evoked leukemogenesis does not require beta-catenin. Leukemia 28(3):698-702. [PubMed: 24189294]  [MGI Ref ID J:206982]

Ni H; Papalia JM; Degen JL; Wagner DD. 2003. Control of thrombus embolization and fibronectin internalization by integrin alpha IIb beta 3 engagement of the fibrinogen gamma chain. Blood 102(10):3609-14. [PubMed: 12855554]  [MGI Ref ID J:86449]

Ni H; Yuen PS; Papalia JM; Trevithick JE; Sakai T; Fassler R; Hynes RO; Wagner DD. 2003. Plasma fibronectin promotes thrombus growth and stability in injured arterioles. Proc Natl Acad Sci U S A 100(5):2415-9. [PubMed: 12606706]  [MGI Ref ID J:82373]

Niendorf S; Oksche A; Kisser A; Lohler J; Prinz M; Schorle H; Feller S; Lewitzky M; Horak I; Knobeloch KP. 2007. Essential role of ubiquitin-specific protease 8 for receptor tyrosine kinase stability and endocytic trafficking in vivo. Mol Cell Biol 27(13):5029-39. [PubMed: 17452457]  [MGI Ref ID J:122732]

Nieswandt B; Brakebusch C; Bergmeier W; Schulte V; Bouvard D; Mokhtari-Nejad R; Lindhout T; Heemskerk JW; Zirngibl H; Fassler R. 2001. Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen. EMBO J 20(9):2120-30. [PubMed: 11331578]  [MGI Ref ID J:78984]

Nieswandt B; Moser M; Pleines I; Varga-Szabo D; Monkley S; Critchley D; Fassler R. 2007. Loss of talin1 in platelets abrogates integrin activation, platelet aggregation, and thrombus formation in vitro and in vivo. J Exp Med 204(13):3113-8. [PubMed: 18086864]  [MGI Ref ID J:129708]

Nishimichi N; Hayashita-Kinoh H; Chen C; Matsuda H; Sheppard D; Yokosaki Y. 2011. Osteopontin Undergoes Polymerization in Vivo and Gains Chemotactic Activity for Neutrophils Mediated by Integrin {alpha}9{beta}1. J Biol Chem 286(13):11170-8. [PubMed: 21321126]  [MGI Ref ID J:170901]

Nishimoto N; Arai S; Ichikawa M; Nakagawa M; Goyama S; Kumano K; Takahashi T; Kamikubo Y; Imai Y; Kurokawa M. 2011. Loss of AML1/Runx1 accelerates the development of MLL-ENL leukemia through down-regulation of p19ARF. Blood 118(9):2541-50. [PubMed: 21757616]  [MGI Ref ID J:177091]

Niu C; Zhang J; Breslin P; Onciu M; Ma Z; Morris SW. 2009. c-Myc is a target of RNA-binding motif protein 15 in the regulation of adult hematopoietic stem cell and megakaryocyte development. Blood 114(10):2087-96. [PubMed: 19542301]  [MGI Ref ID J:152262]

Noda M; Omatsu Y; Sugiyama T; Oishi S; Fujii N; Nagasawa T. 2011. CXCL12-CXCR4 chemokine signaling is essential for NK-cell development in adult mice. Blood 117(2):451-8. [PubMed: 20944068]  [MGI Ref ID J:168425]

Nolte MA; Arens R; Kraus M; van Oers MH; Kraal G; van Lier RA; Mebius RE. 2004. B cells are crucial for both development and maintenance of the splenic marginal zone. J Immunol 172(6):3620-7. [PubMed: 15004164]  [MGI Ref ID J:88620]

Norseen J; Hosooka T; Hammarstedt A; Yore MM; Kant S; Aryal P; Kiernan UA; Phillips DA; Maruyama H; Kraus BJ; Usheva A; Davis RJ; Smith U; Kahn BB. 2012. Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism. Mol Cell Biol 32(10):2010-9. [PubMed: 22431523]  [MGI Ref ID J:185736]

Nunez V; Alameda D; Rico D; Mota R; Gonzalo P; Cedenilla M; Fischer T; Bosca L; Glass CK; Arroyo AG; Ricote M. 2010. Retinoid X receptor alpha controls innate inflammatory responses through the up-regulation of chemokine expression. Proc Natl Acad Sci U S A 107(23):10626-31. [PubMed: 20498053]  [MGI Ref ID J:161295]

O'Carroll D; Mecklenbrauker I; Das PP; Santana A; Koenig U; Enright AJ; Miska EA; Tarakhovsky A. 2007. A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway. Genes Dev 21(16):1999-2004. [PubMed: 17626790]  [MGI Ref ID J:165967]

Oh-Hora M; Komatsu N; Pishyareh M; Feske S; Hori S; Taniguchi M; Rao A; Takayanagi H. 2013. Agonist-selected T cell development requires strong T cell receptor signaling and store-operated calcium entry. Immunity 38(5):881-95. [PubMed: 23499491]  [MGI Ref ID J:203161]

Ohlsson E; Hasemann MS; Willer A; Lauridsen FK; Rapin N; Jendholm J; Porse BT. 2014. Initiation of MLL-rearranged AML is dependent on C/EBPalpha. J Exp Med 211(1):5-13. [PubMed: 24367003]  [MGI Ref ID J:208356]

Olivera A; Eisner C; Kitamura Y; Dillahunt S; Allende L; Tuymetova G; Watford W; Meylan F; Diesner SC; Li L; Schnermann J; Proia RL; Rivera J. 2010. Sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 are vital to recovery from anaphylactic shock in mice. J Clin Invest 120(5):1429-40. [PubMed: 20407207]  [MGI Ref ID J:161468]

Olivera A; Kitamura Y; Wright LD; Allende ML; Chen W; Kaneko-Goto T; Yoshihara Y; Proia RL; Rivera J. 2013. Sphingosine-1-phosphate can promote mast cell hyper-reactivity through regulation of contactin-4 expression. J Leukoc Biol 94(5):1013-24. [PubMed: 23904439]  [MGI Ref ID J:209552]

Onoyama I; Suzuki A; Matsumoto A; Tomita K; Katagiri H; Oike Y; Nakayama K; Nakayama KI. 2011. Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver. J Clin Invest 121(1):342-54. [PubMed: 21123947]  [MGI Ref ID J:171853]

Opferman JT; Iwasaki H; Ong CC; Suh H; Mizuno S; Akashi K; Korsmeyer SJ. 2005. Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells. Science 307(5712):1101-4. [PubMed: 15718471]  [MGI Ref ID J:96127]

Opferman JT; Letai A; Beard C; Sorcinelli MD; Ong CC; Korsmeyer SJ. 2003. Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. Nature 426(6967):671-6. [PubMed: 14668867]  [MGI Ref ID J:86906]

Oravecz-Wilson KI; Philips ST; Yilmaz OH; Ames HM; Li L; Crawford BD; Gauvin AM; Lucas PC; Sitwala K; Downing JR; Morrison SJ; Ross TS. 2009. Persistence of leukemia-initiating cells in a conditional knockin model of an imatinib-responsive myeloproliferative disorder. Cancer Cell 16(2):137-48. [PubMed: 19647224]  [MGI Ref ID J:151974]

Otero DC; Baker DP; David M. 2013. IRF7-Dependent IFN-beta Production in Response to RANKL Promotes Medullary Thymic Epithelial Cell Development. J Immunol 190(7):3289-98. [PubMed: 23440417]  [MGI Ref ID J:194737]

Paik JH; Kollipara R; Chu G; Ji H; Xiao Y; Ding Z; Miao L; Tothova Z; Horner JW; Carrasco DR; Jiang S; Gilliland DG; Chin L; Wong WH; Castrillon DH; DePinho RA. 2007. FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell 128(2):309-23. [PubMed: 17254969]  [MGI Ref ID J:118179]

Pajerowski AG; Shapiro MJ; Gwin K; Sundsbak R; Nelson-Holte M; Medina K; Shapiro VS. 2010. Adult hematopoietic stem cells require NKAP for maintenance and survival. Blood 116(15):2684-93. [PubMed: 20610818]  [MGI Ref ID J:165872]

Pan D; Schomber T; Kalberer CP; Terracciano LM; Hafen K; Krenger W; Hao-Shen H; Deng C; Skoda RC. 2007. Normal erythropoiesis but severe polyposis and bleeding anemia in Smad4-deficient mice. Blood 110(8):3049-55. [PubMed: 17638848]  [MGI Ref ID J:149127]

Pappu R; Schwab SR; Cornelissen I; Pereira JP; Regard JB; Xu Y; Camerer E; Zheng YW; Huang Y; Cyster JG; Coughlin SR. 2007. Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science 316(5822):295-8. [PubMed: 17363629]  [MGI Ref ID J:120783]

Paraiso KH; Ghansah T; Costello A; Engelman RW; Kerr WG. 2007. Induced SHIP deficiency expands myeloid regulatory cells and abrogates graft-versus-host disease. J Immunol 178(5):2893-900. [PubMed: 17312133]  [MGI Ref ID J:144110]

Parathath S; Grauer L; Huang LS; Sanson M; Distel E; Goldberg IJ; Fisher EA. 2011. Diabetes adversely affects macrophages during atherosclerotic plaque regression in mice. Diabetes 60(6):1759-69. [PubMed: 21562077]  [MGI Ref ID J:177946]

Park D; Spencer JA; Koh BI; Kobayashi T; Fujisaki J; Clemens TL; Lin CP; Kronenberg HM; Scadden DT. 2012. Endogenous bone marrow MSCs are dynamic, fate-restricted participants in bone maintenance and regeneration. Cell Stem Cell 10(3):259-72. [PubMed: 22385654]  [MGI Ref ID J:185671]

Park SK; Haase VH; Johnson RS. 2007. von Hippel Lindau tumor suppressor regulates hepatic glucose metabolism by controlling expression of glucose transporter 2 and glucose 6-phosphatase. Int J Oncol 30(2):341-8. [PubMed: 17203215]  [MGI Ref ID J:123030]

Park SM; Deering RP; Lu Y; Tivnan P; Lianoglou S; Al-Shahrour F; Ebert BL; Hacohen N; Leslie C; Daley GQ; Lengner CJ; Kharas MG. 2014. Musashi-2 controls cell fate, lineage bias, and TGF-beta signaling in HSCs. J Exp Med 211(1):71-87. [PubMed: 24395885]  [MGI Ref ID J:208349]

Park SM; Gonen M; Vu L; Minuesa G; Tivnan P; Barlowe TS; Taggart J; Lu Y; Deering RP; Hacohen N; Figueroa ME; Paietta E; Fernandez HF; Tallman MS; Melnick A; Levine R; Leslie C; Lengner CJ; Kharas MG. 2015. Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program. J Clin Invest 125(3):1286-98. [PubMed: 25664853]  [MGI Ref ID J:220547]

Passegue E; Wagner EF; Weissman IL. 2004. JunB deficiency leads to a myeloproliferative disorder arising from hematopoietic stem cells. Cell 119(3):431-43. [PubMed: 15507213]  [MGI Ref ID J:94778]

Paul E; Cronan R; Weston PJ; Boekelheide K; Sedivy JM; Lee SY; Wiest DL; Resnick MB; Klysik JE. 2009. Disruption of Supv3L1 damages the skin and causes sarcopenia, loss of fat, and death. Mamm Genome 20(2):92-108. [PubMed: 19145458]  [MGI Ref ID J:144991]

Pavlova E; Wang S; Archer J; Dekker N; Aerts J; Karlsson S; Cox T. 2013. B cell lymphoma and myeloma in murine Gaucher's disease. (Correction J Pathol 2013;231:544-545) J Pathol 231(1):88-97. [PubMed: 23775597]  [MGI Ref ID J:200010]

Pavlova EV; Archer J; Z Wang S; Dekker N; Aerts JM; Karlsson S; Cox TM. 2015. Inhibition of UDP-glucosylceramide synthase in mice prevents Gaucher disease-associated B-cell malignancy. J Pathol 235(1):113-24. [PubMed: 25256118]  [MGI Ref ID J:216455]

Pelanda R; Hobeika E; Kurokawa T; Zhang Y; Kuppig S; Reth M. 2002. Cre recombinase-controlled expression of the mb-1 allele. Genesis 32(2):154-7. [PubMed: 11857807]  [MGI Ref ID J:75114]

Perry JM; Harandi OF; Porayette P; Hegde S; Kannan AK; Paulson RF. 2009. Maintenance of the BMP4-dependent stress erythropoiesis pathway in the murine spleen requires hedgehog signaling. Blood 113(4):911-8. [PubMed: 18927434]  [MGI Ref ID J:144571]

Perry JM; He XC; Sugimura R; Grindley JC; Haug JS; Ding S; Li L. 2011. Cooperation between both Wnt/{beta}-catenin and PTEN/PI3K/Akt signaling promotes primitive hematopoietic stem cell self-renewal and expansion. Genes Dev 25(18):1928-42. [PubMed: 21890648]  [MGI Ref ID J:176204]

Petzold T; Ruppert R; Pandey D; Barocke V; Meyer H; Lorenz M; Zhang L; Siess W; Massberg S; Moser M. 2013. beta1 integrin-mediated signals are required for platelet granule secretion and hemostasis in mouse. Blood 122(15):2723-31. [PubMed: 24004668]  [MGI Ref ID J:203825]

Philips ST; Hildenbrand ZL; Oravecz-Wilson KI; Foley SB; Mgbemena VE; Ross TS. 2014. Toward a therapeutic reduction of imatinib refractory myeloproliferative neoplasm-initiating cells. Oncogene 33(46):5379-90. [PubMed: 24240679]  [MGI Ref ID J:216270]

Pietras EM; Lakshminarasimhan R; Techner JM; Fong S; Flach J; Binnewies M; Passegue E. 2014. Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons. J Exp Med 211(2):245-62. [PubMed: 24493802]  [MGI Ref ID J:208438]

Pleines I; Dutting S; Cherpokova D; Eckly A; Meyer I; Morowski M; Krohne G; Schulze H; Gachet C; Debili N; Brakebusch C; Nieswandt B. 2013. Defective tubulin organization and proplatelet formation in murine megakaryocytes lacking Rac1 and Cdc42. Blood 122(18):3178-87. [PubMed: 23861250]  [MGI Ref ID J:203299]

Polic B; Kunkel D; Scheffold A; Rajewsky K. 2001. How alpha beta T cells deal with induced TCR alpha ablation. Proc Natl Acad Sci U S A 98(15):8744-9. [PubMed: 11447257]  [MGI Ref ID J:79298]

Pondarre C; Antiochos BB; Campagna DR; Clarke SL; Greer EL; Deck KM; McDonald A; Han AP; Medlock A; Kutok JL; Anderson SA; Eisenstein RS; Fleming MD. 2006. The mitochondrial ATP-binding cassette transporter Abcb7 is essential in mice and participates in cytosolic iron-sulfur cluster biogenesis. Hum Mol Genet 15(6):953-64. [PubMed: 16467350]  [MGI Ref ID J:106838]

Pondarre C; Campagna DR; Antiochos B; Sikorski L; Mulhern H; Fleming MD. 2007. Abcb7, the gene responsible for X-linked sideroblastic anemia with ataxia, is essential for hematopoiesis. Blood 109(8):3567-9. [PubMed: 17192398]  [MGI Ref ID J:136594]

Poulos MG; Guo P; Kofler NM; Pinho S; Gutkin MC; Tikhonova A; Aifantis I; Frenette PS; Kitajewski J; Rafii S; Butler JM. 2013. Endothelial Jagged-1 is necessary for homeostatic and regenerative hematopoiesis. Cell Rep 4(5):1022-34. [PubMed: 24012753]  [MGI Ref ID J:202842]

Priestley GV; Scott LM; Ulyanova T; Papayannopoulou T. 2006. Lack of alpha4 integrin expression in stem cells restricts competitive function and self-renewal activity. Blood 107(7):2959-67. [PubMed: 16357327]  [MGI Ref ID J:131263]

Putz G; Rosner A; Nuesslein I; Schmitz N; Buchholz F. 2006. AML1 deletion in adult mice causes splenomegaly and lymphomas. Oncogene 25(6):929-39. [PubMed: 16247465]  [MGI Ref ID J:105709]

Qi X; Hong J; Chaves L; Zhuang Y; Chen Y; Wang D; Chabon J; Graham B; Ohmori K; Li Y; Huang H. 2013. Antagonistic regulation by the transcription factors C/EBPalpha and MITF specifies basophil and mast cell fates. Immunity 39(1):97-110. [PubMed: 23871207]  [MGI Ref ID J:208242]

Qian C; Qian L; Yu Y; An H; Guo Z; Han Y; Chen Y; Bai Y; Wang Q; Cao X. 2013. Fas signal promotes the immunosuppressive function of regulatory dendritic cells via the ERK/beta-catenin pathway. J Biol Chem 288(39):27825-35. [PubMed: 23943615]  [MGI Ref ID J:203852]

Qian Z; Chen L; Fernald AA; Williams BO; Le Beau MM. 2008. A critical role for Apc in hematopoietic stem and progenitor cell survival. J Exp Med 205(9):2163-75. [PubMed: 18725524]  [MGI Ref ID J:138809]

Qin G; Ii M; Silver M; Wecker A; Bord E; Ma H; Gavin M; Goukassian DA; Yoon YS; Papayannopoulou T; Asahara T; Kearney M; Thorne T; Curry C; Eaton L; Heyd L; Dinesh D; Kishore R; Zhu Y; Losordo DW. 2006. Functional disruption of alpha4 integrin mobilizes bone marrow-derived endothelial progenitors and augments ischemic neovascularization. J Exp Med 203(1):153-63. [PubMed: 16401693]  [MGI Ref ID J:118824]

Quast T; Tappertzhofen B; Schild C; Grell J; Czeloth N; Forster R; Alon R; Fraemohs L; Dreck K; Weber C; Lammermann T; Sixt M; Kolanus W. 2009. Cytohesin-1 controls the activation of RhoA and modulates integrin-dependent adhesion and migration of dendritic cells. Blood 113(23):5801-10. [PubMed: 19346499]  [MGI Ref ID J:149500]

Quere R; Karlsson G; Hertwig F; Rissler M; Lindqvist B; Fioretos T; Vandenberghe P; Slovak ML; Cammenga J; Karlsson S. 2011. Smad4 binds Hoxa9 in the cytoplasm and protects primitive hematopoietic cells against nuclear activation by Hoxa9 and leukemia transformation. Blood 117(22):5918-30. [PubMed: 21471525]  [MGI Ref ID J:174718]

Quivoron C; Couronne L; Della Valle V; Lopez CK; Plo I; Wagner-Ballon O; Do Cruzeiro M; Delhommeau F; Arnulf B; Stern MH; Godley L; Opolon P; Tilly H; Solary E; Duffourd Y; Dessen P; Merle-Beral H; Nguyen-Khac F; Fontenay M; Vainchenker W; Bastard C; Mercher T; Bernard OA. 2011. TET2 Inactivation Results in Pleiotropic Hematopoietic Abnormalities in Mouse and Is a Recurrent Event during Human Lymphomagenesis. Cancer Cell 20(1):25-38. [PubMed: 21723201]  [MGI Ref ID J:174052]

Radtke F; Wilson A; Stark G; Bauer M; van Meerwijk J; MacDonald HR; Aguet M. 1999. Deficient T cell fate specification in mice with an induced inactivation of Notch1. Immunity 10(5):547-58. [PubMed: 10367900]  [MGI Ref ID J:55400]

Raffel GD; Mercher T; Shigematsu H; Williams IR; Cullen DE; Akashi K; Bernard OA; Gilliland DG. 2007. Ott1(Rbm15) has pleiotropic roles in hematopoietic development. Proc Natl Acad Sci U S A 104(14):6001-6. [PubMed: 17376872]  [MGI Ref ID J:120321]

Ragu C; Boukour S; Elain G; Wagner-Ballon O; Raslova H; Debili N; Olson EN; Daegelen D; Vainchenker W; Bernard OA; Penard-Lacronique V. 2010. The serum response factor (SRF)/megakaryocytic acute leukemia (MAL) network participates in megakaryocyte development. Leukemia 24(6):1227-30. [PubMed: 20428204]  [MGI Ref ID J:161966]

Ragu C; Elain G; Mylonas E; Ottolenghi C; Cagnard N; Daegelen D; Passegue E; Vainchenker W; Bernard OA; Penard-Lacronique V. 2010. The transcription factor Srf regulates hematopoietic stem cell adhesion. Blood 116(22):4464-73. [PubMed: 20709909]  [MGI Ref ID J:166639]

Rajasekaran K; Chu H; Kumar P; Xiao Y; Tinguely M; Samarakoon A; Kim TW; Li X; Thakar MS; Zhang J; Malarkannan S. 2011. Transforming growth factor-beta-activated kinase 1 regulates natural killer cell-mediated cytotoxicity and cytokine production. J Biol Chem 286(36):31213-24. [PubMed: 21771792]  [MGI Ref ID J:176611]

Rajasekaran K; Kumar P; Schuldt KM; Peterson EJ; Vanhaesebroeck B; Dixit V; Thakar MS; Malarkannan S. 2013. Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells. Nat Immunol 14(11):1127-36. [PubMed: 24036998]  [MGI Ref ID J:208208]

Ramsey SA; Vengrenyuk Y; Menon P; Podolsky I; Feig JE; Aderem A; Fisher EA; Gold ES. 2014. Epigenome-guided analysis of the transcriptome of plaque macrophages during atherosclerosis regression reveals activation of the Wnt signaling pathway. PLoS Genet 10(12):e1004828. [PubMed: 25474352]  [MGI Ref ID J:222183]

Ranson T; Vosshenrich CA; Corcuff E; Richard O; Muller W; Di Santo JP. 2003. IL-15 is an essential mediator of peripheral NK-cell homeostasis. Blood 101(12):4887-93. [PubMed: 12586624]  [MGI Ref ID J:132257]

Ribeiro VS; Hasan M; Wilson A; Boucontet L; Pereira P; Lesjean-Pottier S; Satoh-Takayama N; Di Santo JP; Vosshenrich CA. 2010. Cutting edge: Thymic NK cells develop independently from T cell precursors. J Immunol 185(9):4993-7. [PubMed: 20889548]  [MGI Ref ID J:165182]

Ricote M; Snyder CS; Leung HY; Chen J; Chien KR; Glass CK. 2006. Normal hematopoiesis after conditional targeting of RXRalpha in murine hematopoietic stem/progenitor cells. J Leukoc Biol 80(4):850-61. [PubMed: 16888087]  [MGI Ref ID J:113089]

Ringelhan M; Schmid RM; Geisler F. 2012. The NF-kappaB subunit RelA/p65 is dispensable for successful liver regeneration after partial hepatectomy in mice. PLoS One 7(10):e46469. [PubMed: 23049704]  [MGI Ref ID J:191955]

Rius J; Guma M; Schachtrup C; Akassoglou K; Zinkernagel AS; Nizet V; Johnson RS; Haddad GG; Karin M. 2008. NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature 453(7196):807-11. [PubMed: 18432192]  [MGI Ref ID J:136296]

Roberts CW; Leroux MM; Fleming MD; Orkin SH. 2002. Highly penetrant, rapid tumorigenesis through conditional inversion of the tumor suppressor gene Snf5. Cancer Cell 2(5):415-25. [PubMed: 12450796]  [MGI Ref ID J:80224]

Roderick JE; Gonzalez-Perez G; Kuksin CA; Dongre A; Roberts ER; Srinivasan J; Andrzejewski C Jr; Fauq AH; Golde TE; Miele L; Minter LM. 2013. Therapeutic targeting of NOTCH signaling ameliorates immune-mediated bone marrow failure of aplastic anemia. J Exp Med 210(7):1311-29. [PubMed: 23733784]  [MGI Ref ID J:201337]

Roebroek AJ; Taylor NA; Louagie E; Pauli I; Smeijers L; Snellinx A; Lauwers A; Van de Ven WJ; Hartmann D; Creemers JW. 2004. Limited redundancy of the proprotein convertase furin in mouse liver. J Biol Chem 279(51):53442-50. [PubMed: 15471862]  [MGI Ref ID J:118515]

Rosenberg S; Zhang H; Zhang J. 2011. FADD deficiency impairs early hematopoiesis in the bone marrow. J Immunol 186(1):203-13. [PubMed: 21115735]  [MGI Ref ID J:168722]

Ross K; Sedello AK; Todd GP; Paszkowski-Rogacz M; Bird AW; Ding L; Grinenko T; Behrens K; Hubner N; Mann M; Waskow C; Stocking C; Buchholz F. 2012. Polycomb group ring finger 1 cooperates with Runx1 in regulating differentiation and self-renewal of hematopoietic cells. Blood 119(18):4152-61. [PubMed: 22411870]  [MGI Ref ID J:184985]

Rothweiler S; Dill MT; Terracciano L; Makowska Z; Quagliata L; Hlushchuk R; Djonov V; Heim MH; Semela D. 2015. Generation of a murine hepatic angiosarcoma cell line and reproducible mouse tumor model. Lab Invest 95(3):351-62. [PubMed: 25418579]  [MGI Ref ID J:218611]

Rowland SL; DePersis CL; Torres RM; Pelanda R. 2010. Ras activation of Erk restores impaired tonic BCR signaling and rescues immature B cell differentiation. J Exp Med 207(3):607-21. [PubMed: 20176802]  [MGI Ref ID J:158819]

Ruocco MG; Maeda S; Park JM; Lawrence T; Hsu LC; Cao Y; Schett G; Wagner EF; Karin M. 2005. I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss. J Exp Med 201(10):1677-87. [PubMed: 15897281]  [MGI Ref ID J:99211]

Ruud J; Wilhelms DB; Nilsson A; Eskilsson A; Tang YJ; Strohle P; Caesar R; Schwaninger M; Wunderlich T; Backhed F; Engblom D; Blomqvist A. 2013. Inflammation- and tumor-induced anorexia and weight loss require MyD88 in hematopoietic/myeloid cells but not in brain endothelial or neural cells. FASEB J 27(5):1973-80. [PubMed: 23395911]  [MGI Ref ID J:197842]

Ryan MA; Nattamai KJ; Xing E; Schleimer D; Daria D; Sengupta A; Kohler A; Liu W; Gunzer M; Jansen M; Ratner N; Le Cras TD; Waterstrat A; Van Zant G; Cancelas JA; Zheng Y; Geiger H. 2010. Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization. Nat Med 16(10):1141-6. [PubMed: 20871610]  [MGI Ref ID J:165196]

Sabnis AJ; Cheung LS; Dail M; Kang HC; Santaguida M; Hermiston ML; Passegue E; Shannon K; Braun BS. 2009. Oncogenic Kras initiates leukemia in hematopoietic stem cells. PLoS Biol 7(3):e59. [PubMed: 19296721]  [MGI Ref ID J:149615]

Sagiv Y; Bai L; Wei DG; Agami R; Savage PB; Teyton L; Bendelac A. 2007. A distal effect of microsomal triglyceride transfer protein deficiency on the lysosomal recycling of CD1d. J Exp Med 204(4):921-8. [PubMed: 17403933]  [MGI Ref ID J:125608]

Saito T; Chiba S; Ichikawa M; Kunisato A; Asai T; Shimizu K; Yamaguchi T; Yamamoto G; Seo S; Kumano K; Nakagami-Yamaguchi E; Hamada Y; Aizawa S; Hirai H. 2003. Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development. Immunity 18(5):675-85. [PubMed: 12753744]  [MGI Ref ID J:83476]

Sakai K; Jawaid S; Sasaki T; Bou-Gharios G; Sakai T. 2014. Transforming growth factor-beta-independent role of connective tissue growth factor in the development of liver fibrosis. Am J Pathol 184(10):2611-7. [PubMed: 25108224]  [MGI Ref ID J:214834]

Sakai T; Johnson KJ; Murozono M; Sakai K; Magnuson MA; Wieloch T; Cronberg T; Isshiki A; Erickson HP; Fassler R. 2001. Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis. Nat Med 7(3):324-30. [PubMed: 11231631]  [MGI Ref ID J:67961]

Sakata-Yanagimoto M; Sakai T; Miyake Y; Saito TI; Maruyama H; Morishita Y; Nakagami-Yamaguchi E; Kumano K; Yagita H; Fukayama M; Ogawa S; Kurokawa M; Yasutomo K; Chiba S. 2011. Notch2 signaling is required for proper mast cell distribution and mucosal immunity in the intestine. Blood 117(1):128-34. [PubMed: 20971948]  [MGI Ref ID J:168409]

Salmon JM; Slater NJ; Hall MA; McCormack MP; Nutt SL; Jane SM; Curtis DJ. 2007. Aberrant mast-cell differentiation in mice lacking the stem-cell leukemia gene. Blood 110(10):3573-81. [PubMed: 17644741]  [MGI Ref ID J:149122]

Sander LE; Obermeier F; Dierssen U; Kroy DC; Singh AK; Seidler U; Streetz KL; Lutz HH; Muller W; Tacke F; Trautwein C. 2008. Gp130 signaling promotes development of acute experimental colitis by facilitating early neutrophil/macrophage recruitment and activation. J Immunol 181(5):3586-94. [PubMed: 18714032]  [MGI Ref ID J:138939]

Sankaran VG; Orkin SH; Walkley CR. 2008. Rb intrinsically promotes erythropoiesis by coupling cell cycle exit with mitochondrial biogenesis. Genes Dev 22(4):463-75. [PubMed: 18258751]  [MGI Ref ID J:210155]

Sankaran VG; Xu J; Ragoczy T; Ippolito GC; Walkley CR; Maika SD; Fujiwara Y; Ito M; Groudine M; Bender MA; Tucker PW; Orkin SH. 2009. Developmental and species-divergent globin switching are driven by BCL11A. Nature 460(7259):1093-7. [PubMed: 19657335]  [MGI Ref ID J:151995]

Sasca D; Hahnel PS; Szybinski J; Khawaja K; Kriege O; Pante SV; Bullinger L; Strand S; Strand D; Theobald M; Kindler T. 2014. SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia. Blood 124(1):121-33. [PubMed: 24855208]  [MGI Ref ID J:214302]

Sathyanarayana P; Dev A; Pradeep A; Ufkin M; Licht JD; Wojchowski DM. 2012. Spry1 as a novel regulator of erythropoiesis, EPO/EPOR target, and suppressor of JAK2. Blood 119(23):5522-31. [PubMed: 22508938]  [MGI Ref ID J:188083]

Satyanarayana A; Gudmundsson KO; Chen X; Coppola V; Tessarollo L; Keller JR; Hou SX. 2010. RapGEF2 is essential for embryonic hematopoiesis but dispensable for adult hematopoiesis. Blood 116(16):2921-31. [PubMed: 20595512]  [MGI Ref ID J:165879]

Sawai CM; Freund J; Oh P; Ndiaye-Lobry D; Bretz JC; Strikoudis A; Genesca L; Trimarchi T; Kelliher MA; Clark M; Soulier J; Chen-Kiang S; Aifantis I. 2012. Therapeutic targeting of the cyclin D3:CDK4/6 complex in T cell leukemia. Cancer Cell 22(4):452-65. [PubMed: 23079656]  [MGI Ref ID J:192031]

Scheller M; Huelsken J; Rosenbauer F; Taketo MM; Birchmeier W; Tenen DG; Leutz A. 2006. Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation. Nat Immunol 7(10):1037-47. [PubMed: 16951686]  [MGI Ref ID J:112659]

Scheller M; Schonheit J; Zimmermann K; Leser U; Rosenbauer F; Leutz A. 2013. Cross talk between Wnt/beta-catenin and Irf8 in leukemia progression and drug resistance. J Exp Med 210(11):2239-56. [PubMed: 24101380]  [MGI Ref ID J:204584]

Schindler JW; Van Buren D; Foudi A; Krejci O; Qin J; Orkin SH; Hock H. 2009. TEL-AML1 corrupts hematopoietic stem cells to persist in the bone marrow and initiate leukemia. Cell Stem Cell 5(1):43-53. [PubMed: 19570513]  [MGI Ref ID J:151639]

Schmedt C; Saijo K; Niidome T; Kuhn R; Aizawa S; Tarakhovsky A. 1998. Csk controls antigen receptor-mediated development and selection of T-lineage cells. Nature 394(6696):901-4. [PubMed: 9732874]  [MGI Ref ID J:49654]

Schmedt C; Tarakhovsky A. 2001. Autonomous maturation of alpha/beta T lineage cells in the absence of COOH-terminal Src kinase (Csk). J Exp Med 193(7):815-26. [PubMed: 11283154]  [MGI Ref ID J:120548]

Schmidt S; Nakchbandi I; Ruppert R; Kawelke N; Hess MW; Pfaller K; Jurdic P; Fassler R; Moser M. 2011. Kindlin-3-mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorption. J Cell Biol 192(5):883-97. [PubMed: 21357746]  [MGI Ref ID J:170685]

Schramek D; Leibbrandt A; Sigl V; Kenner L; Pospisilik JA; Lee HJ; Hanada R; Joshi PA; Aliprantis A; Glimcher L; Pasparakis M; Khokha R; Ormandy CJ; Widschwendter M; Schett G; Penninger JM. 2010. Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer. Nature 468(7320):98-102. [PubMed: 20881962]  [MGI Ref ID J:166078]

Schramm M; Wiegmann K; Schramm S; Gluschko A; Herb M; Utermohlen O; Kronke M. 2014. Riboflavin (vitamin B2 ) deficiency impairs NADPH oxidase 2 (Nox2) priming and defense against Listeria monocytogenes. Eur J Immunol 44(3):728-41. [PubMed: 24272050]  [MGI Ref ID J:209081]

Schuler A; Schwieger M; Engelmann A; Weber K; Horn S; Muller U; Arnold MA; Olson EN; Stocking C. 2008. The MADS transcription factor Mef2c is a pivotal modulator of myeloid cell fate. Blood 111(9):4532-41. [PubMed: 18326819]  [MGI Ref ID J:134352]

Schwieger M; Schuler A; Forster M; Engelmann A; Arnold MA; Delwel R; Valk PJ; Lohler J; Slany RK; Olson EN; Stocking C. 2009. Homing and invasiveness of MLL/ENL leukemic cells is regulated by MEF2C. Blood 114(12):2476-88. [PubMed: 19584403]  [MGI Ref ID J:152811]

Scott LM; Priestley GV; Papayannopoulou T. 2003. Deletion of alpha4 integrins from adult hematopoietic cells reveals roles in homeostasis, regeneration, and homing. Mol Cell Biol 23(24):9349-60. [PubMed: 14645544]  [MGI Ref ID J:86861]

Sekiguchi S; Kimura K; Chiyo T; Ohtsuki T; Tobita Y; Tokunaga Y; Yasui F; Tsukiyama-Kohara K; Wakita T; Tanaka T; Miyasaka M; Mizuno K; Hayashi Y; Hishima T; Matsushima K; Kohara M. 2012. Immunization with a recombinant vaccinia virus that encodes nonstructural proteins of the hepatitis C virus suppresses viral protein levels in mouse liver. PLoS One 7(12):e51656. [PubMed: 23284733]  [MGI Ref ID J:195632]

Sengupta A; Duran A; Ishikawa E; Florian MC; Dunn SK; Ficker AM; Leitges M; Geiger H; Diaz-Meco M; Moscat J; Cancelas JA. 2011. Atypical protein kinase C (aPKC{zeta} and aPKC{lambda}) is dispensable for mammalian hematopoietic stem cell activity and blood formation. Proc Natl Acad Sci U S A 108(24):9957-62. [PubMed: 21653884]  [MGI Ref ID J:173454]

Shenderov K; Riteau N; Yip R; Mayer-Barber KD; Oland S; Hieny S; Fitzgerald P; Oberst A; Dillon CP; Green DR; Cerundolo V; Sher A. 2014. Cutting edge: Endoplasmic reticulum stress licenses macrophages to produce mature IL-1beta in response to TLR4 stimulation through a caspase-8- and TRIF-dependent pathway. J Immunol 192(5):2029-33. [PubMed: 24489101]  [MGI Ref ID J:209937]

Shibata K; Yamada H; Sato T; Dejima T; Nakamura M; Ikawa T; Hara H; Yamasaki S; Kageyama R; Iwakura Y; Kawamoto H; Toh H; Yoshikai Y. 2011. Notch-Hes1 pathway is required for the development of IL-17-producing {gamma}{delta} T cells. Blood 118(3):586-93. [PubMed: 21606479]  [MGI Ref ID J:174874]

Shik Park C; Lee PH; Yamada T; Burns A; Shen Y; Puppi M; Lacorazza HD. 2012. Kruppel-like factor 4 (KLF4) promotes the survival of natural killer cells and maintains the number of conventional dendritic cells in the spleen. J Leukoc Biol 91(5):739-50. [PubMed: 22345706]  [MGI Ref ID J:183785]

Shinnick KM; Eklund EA; McGarry TJ. 2010. Geminin deletion from hematopoietic cells causes anemia and thrombocytosis in mice. J Clin Invest 120(12):4303-15. [PubMed: 21041951]  [MGI Ref ID J:171741]

Siggins SL; Nguyen NY; McCormack MP; Vasudevan S; Villani R; Jane SM; Wainwright BJ; Curtis DJ. 2009. The Hedgehog receptor Patched1 regulates myeloid and lymphoid progenitors by distinct cell-extrinsic mechanisms. Blood 114(5):995-1004. [PubMed: 19483124]  [MGI Ref ID J:151338]

Simon C; Chagraoui J; Krosl J; Gendron P; Wilhelm B; Lemieux S; Boucher G; Chagnon P; Drouin S; Lambert R; Rondeau C; Bilodeau A; Lavallee S; Sauvageau M; Hebert J; Sauvageau G. 2012. A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia. Genes Dev 26(7):651-6. [PubMed: 22431509]  [MGI Ref ID J:182211]

Singbrant S; Karlsson G; Ehinger M; Olsson K; Jaako P; Miharada K; Stadtfeld M; Graf T; Karlsson S. 2010. Canonical BMP signaling is dispensable for hematopoietic stem cell function in both adult and fetal liver hematopoiesis, but essential to preserve colon architecture. Blood 115(23):4689-98. [PubMed: 20371744]  [MGI Ref ID J:161541]

Singbrant S; Moody JL; Blank U; Karlsson G; Umans L; Zwijsen A; Karlsson S. 2006. Smad5 is dispensable for adult murine hematopoiesis. Blood 108(12):3707-12. [PubMed: 16896158]  [MGI Ref ID J:140441]

Sirac C; Bridoux F; Carrion C; Devuyst O; Fernandez B; Goujon JM; El Hamel C; Aldigier JC; Touchard G; Cogne M. 2006. Role of the monoclonal kappa chain V domain and reversibility of renal damage in a transgenic model of acquired Fanconi syndrome. Blood 108(2):536-43. [PubMed: 16543471]  [MGI Ref ID J:135758]

Sjogren AK; Andersson KM; Khan O; Olofsson FJ; Karlsson C; Bergo MO. 2011. Inactivating GGTase-I reduces disease phenotypes in a mouse model of K-RAS-induced myeloproliferative disease. Leukemia 25(1):186-9. [PubMed: 20975663]  [MGI Ref ID J:167639]

Sjogren K; Liu JL; Blad K; Skrtic S; Vidal O; Wallenius V; LeRoith D; Tornell J; Isaksson OG; Jansson JO; Ohlsson C. 1999. Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice. Proc Natl Acad Sci U S A 96(12):7088-92. [PubMed: 10359843]  [MGI Ref ID J:55718]

Sjogren K; Sheng M; Moverare S; Liu JL; Wallenius K; Tornell J; Isaksson O; Jansson JO; Mohan S; Ohlsson C. 2002. Effects of liver-derived insulin-like growth factor I on bone metabolism in mice. J Bone Miner Res 17(11):1977-87. [PubMed: 12412805]  [MGI Ref ID J:111425]

Skogsberg J; Dicker A; Ryden M; Astrom G; Nilsson R; Bhuiyan H; Vitols S; Mairal A; Langin D; Alberts P; Walum E; Tegner J; Hamsten A; Arner P; Bjorkegren J. 2008. ApoB100-LDL acts as a metabolic signal from liver to peripheral fat causing inhibition of lipolysis in adipocytes. PLoS ONE 3(11):e3771. [PubMed: 19020660]  [MGI Ref ID J:143905]

Skogsberg J; Lundstrom J; Kovacs A; Nilsson R; Noori P; Maleki S; Kohler M; Hamsten A; Tegner J; Bjorkegren J. 2008. Transcriptional profiling uncovers a network of cholesterol-responsive atherosclerosis target genes. PLoS Genet 4(3):e1000036. [PubMed: 18369455]  [MGI Ref ID J:136835]

So JS; Hur KY; Tarrio M; Ruda V; Frank-Kamenetsky M; Fitzgerald K; Koteliansky V; Lichtman AH; Iwawaki T; Glimcher LH; Lee AH. 2012. Silencing of lipid metabolism genes through IRE1alpha-mediated mRNA decay lowers plasma lipids in mice. Cell Metab 16(4):487-99. [PubMed: 23040070]  [MGI Ref ID J:190921]

Song R; Kim YW; Koo BK; Jeong HW; Yoon MJ; Yoon KJ; Jun DJ; Im SK; Shin J; Kong MP; Kim KT; Yoon K; Kong YY. 2008. Mind bomb 1 in the lymphopoietic niches is essential for T and marginal zone B cell development. J Exp Med 205(11):2525-36. [PubMed: 18824586]  [MGI Ref ID J:140960]

Song SJ; Ito K; Ala U; Kats L; Webster K; Sun SM; Jongen-Lavrencic M; Manova-Todorova K; Teruya-Feldstein J; Avigan DE; Delwel R; Pandolfi PP. 2013. The Oncogenic MicroRNA miR-22 Targets the TET2 Tumor Suppressor to Promote Hematopoietic Stem Cell Self-Renewal and Transformation. Cell Stem Cell 13(1):87-101. [PubMed: 23827711]  [MGI Ref ID J:199366]

Souabni A; Cobaleda C; Schebesta M; Busslinger M. 2002. Pax5 promotes B lymphopoiesis and blocks T cell development by repressing Notch1. Immunity 17(6):781-93. [PubMed: 12479824]  [MGI Ref ID J:80815]

Souroullas GP; Salmon JM; Sablitzky F; Curtis DJ; Goodell MA. 2009. Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival. Cell Stem Cell 4(2):180-6. [PubMed: 19200805]  [MGI Ref ID J:149689]

Sportoletti P; Varasano E; Rossi R; Bereshchenko O; Cecchini D; Gionfriddo I; Bolli N; Tiacci E; Intermesoli T; Zanghi P; Masciulli A; Martelli MP; Falzetti F; Martelli MF; Falini B. 2013. The human NPM1 mutation A perturbs megakaryopoiesis in a conditional mouse model. Blood 121(17):3447-58. [PubMed: 23435463]  [MGI Ref ID J:196690]

Staber PB; Zhang P; Ye M; Welner RS; Levantini E; Di Ruscio A; Ebralidze AK; Bach C; Zhang H; Zhang J; Vanura K; Delwel R; Yang H; Huang G; Tenen DG. 2014. The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells. Blood 124(15):2391-9. [PubMed: 25185713]  [MGI Ref ID J:218696]

Staber PB; Zhang P; Ye M; Welner RS; Nombela-Arrieta C; Bach C; Kerenyi M; Bartholdy BA; Zhang H; Alberich-Jorda M; Lee S; Yang H; Ng F; Zhang J; Leddin M; Silberstein LE; Hoefler G; Orkin SH; Gottgens B; Rosenbauer F; Huang G; Tenen DG. 2013. Sustained PU.1 levels balance cell-cycle regulators to prevent exhaustion of adult hematopoietic stem cells. Mol Cell 49(5):934-46. [PubMed: 23395001]  [MGI Ref ID J:196609]

Starck J; Weiss-Gayet M; Gonnet C; Guyot B; Vicat JM; Morle F. 2010. Inducible Fli-1 gene deletion in adult mice modifies several myeloid lineage commitment decisions and accelerates proliferation arrest and terminal erythrocytic differentiation. Blood 116(23):4795-805. [PubMed: 20733157]  [MGI Ref ID J:167426]

Staser K; Park SJ; Rhodes SD; Zeng Y; He YZ; Shew MA; Gehlhausen JR; Cerabona D; Menon K; Chen S; Sun Z; Yuan J; Ingram DA; Nalepa G; Yang FC; Clapp DW. 2013. Normal hematopoiesis and neurofibromin-deficient myeloproliferative disease require Erk. J Clin Invest 123(1):329-34. [PubMed: 23221339]  [MGI Ref ID J:194159]

Staser K; Shew MA; Michels EG; Mwanthi MM; Yang FC; Clapp DW; Park SJ. 2013. A Pak1-PP2A-ERM signaling axis mediates F-actin rearrangement and degranulation in mast cells. Exp Hematol 41(1):56-66.e2. [PubMed: 23063725]  [MGI Ref ID J:196216]

Stehling-Sun S; Dade J; Nutt SL; DeKoter RP; Camargo FD. 2009. Regulation of lymphoid versus myeloid fate 'choice' by the transcription factor Mef2c. Nat Immunol 10(3):289-96. [PubMed: 19169261]  [MGI Ref ID J:146135]

Stein SJ; Baldwin AS. 2013. Deletion of the NF-kappaB subunit p65/RelA in the hematopoietic compartment leads to defects in hematopoietic stem cell function. Blood 121(25):5015-24. [PubMed: 23670180]  [MGI Ref ID J:200952]

Stepniak E; Ricci R; Eferl R; Sumara G; Sumara I; Rath M; Hui L; Wagner EF. 2006. c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity. Genes Dev 20(16):2306-14. [PubMed: 16912279]  [MGI Ref ID J:111671]

Stoddart A; Fernald AA; Wang J; Davis EM; Karrison T; Anastasi J; Le Beau MM. 2014. Haploinsufficiency of del(5q) genes, Egr1 and Apc, cooperate with Tp53 loss to induce acute myeloid leukemia in mice. Blood 123(7):1069-78. [PubMed: 24381225]  [MGI Ref ID J:208692]

Stoddart A; Wang J; Fernald AA; Karrison T; Anastasi J; Le Beau MM. 2014. Cell intrinsic and extrinsic factors synergize in mice with haploinsufficiency for Tp53, and two human del(5q) genes, Egr1 and Apc. Blood 123(2):228-38. [PubMed: 24264229]  [MGI Ref ID J:208082]

Stoffels JM; Hoekstra D; Franklin RJ; Baron W; Zhao C. 2015. The EIIIA domain from astrocyte-derived fibronectin mediates proliferation of oligodendrocyte progenitor cells following CNS demyelination. Glia 63(2):242-56. [PubMed: 25156142]  [MGI Ref ID J:217763]

Streetz KL; Tacke F; Leifeld L; Wustefeld T; Graw A; Klein C; Kamino K; Spengler U; Kreipe H; Kubicka S; Muller W; Manns MP; Trautwein C. 2003. Interleukin 6/gp130-dependent pathways are protective during chronic liver diseases. Hepatology 38(1):218-29. [PubMed: 12830005]  [MGI Ref ID J:105827]

Stumpf M; Yue X; Schmitz S; Luche H; Reddy JK; Borggrefe T. 2010. Specific erythroid-lineage defect in mice conditionally deficient for Mediator subunit Med1. Proc Natl Acad Sci U S A :. [PubMed: 21098667]  [MGI Ref ID J:167145]

Su IH; Basavaraj A; Krutchinsky AN; Hobert O; Ullrich A; Chait BT; Tarakhovsky A. 2003. Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement. Nat Immunol 4(2):124-31. [PubMed: 12496962]  [MGI Ref ID J:83216]

Sugiyama T; Kohara H; Noda M; Nagasawa T. 2006. Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches. Immunity 25(6):977-88. [PubMed: 17174120]  [MGI Ref ID J:116780]

Sullivan AL; Benner C; Heinz S; Huang W; Xie L; Miano JM; Glass CK. 2011. Serum response factor utilizes distinct promoter- and enhancer-based mechanisms to regulate cytoskeletal gene expression in macrophages. Mol Cell Biol 31(4):861-75. [PubMed: 21135125]  [MGI Ref ID J:170425]

Summers AR; Fischer MA; Stengel KR; Zhao Y; Kaiser JF; Wells CE; Hunt A; Bhaskara S; Luzwick JW; Sampathi S; Chen X; Thompson MA; Cortez D; Hiebert SW. 2013. HDAC3 is essential for DNA replication in hematopoietic progenitor cells. J Clin Invest 123(7):3112-23. [PubMed: 23921131]  [MGI Ref ID J:201622]

Svensson J; Diez M; Engel J; Wass C; Tivesten A; Jansson JO; Isaksson O; Archer T; Hokfelt T; Ohlsson C. 2006. Endocrine, liver-derived IGF-I is of importance for spatial learning and memory in old mice. J Endocrinol 189(3):617-27. [PubMed: 16731792]  [MGI Ref ID J:109081]

Svensson J; Kindblom J; Shao R; Moverare-Skrtic S; Lagerquist MK; Andersson N; Sjogren K; Venken K; Vanderschueren D; Jansson JO; Isaksson O; Ohlsson C. 2008. Liver-derived IGF1 enhances the androgenic response in prostate. J Endocrinol 199(3):489-97. [PubMed: 18827067]  [MGI Ref ID J:142809]

Svensson J; Sjogren K; Faldt J; Andersson N; Isaksson O; Jansson JO; Ohlsson C. 2011. Liver-derived IGF-I regulates mean life span in mice. PLoS One 6(7):e22640. [PubMed: 21799924]  [MGI Ref ID J:175763]

Svensson J; Tivesten A; Sjogren K; Isaksson O; Bergstrom G; Mohan S; Molne J; Isgaard J; Ohlsson C. 2007. Liver-derived IGF-I regulates kidney size, sodium reabsorption, and renal IGF-II expression. J Endocrinol 193(3):359-66. [PubMed: 17535874]  [MGI Ref ID J:121798]

Sykes SM; Lane SW; Bullinger L; Kalaitzidis D; Yusuf R; Saez B; Ferraro F; Mercier F; Singh H; Brumme KM; Acharya SS; Scholl C; Tothova Z; Attar EC; Frohling S; Depinho RA; Armstrong SA; Gilliland DG; Scadden DT. 2011. AKT/FOXO Signaling Enforces Reversible Differentiation Blockade in Myeloid Leukemias. Cell 146(5):697-708. [PubMed: 21884932]  [MGI Ref ID J:176214]

Szczur K; Zheng Y; Filippi MD. 2009. The small Rho GTPase Cdc42 regulates neutrophil polarity via CD11b integrin signaling. Blood 114(20):4527-37. [PubMed: 19752396]  [MGI Ref ID J:154928]

TaconicArtemis. 2012. Recombinase Mice Artemis :1-2.  [MGI Ref ID J:188321]

Takeda S; Chen DY; Westergard TD; Fisher JK; Rubens JA; Sasagawa S; Kan JT; Korsmeyer SJ; Cheng EH; Hsieh JJ. 2006. Proteolysis of MLL family proteins is essential for Taspase1-orchestrated cell cycle progression. Genes Dev 20(17):2397-409. [PubMed: 16951254]  [MGI Ref ID J:112159]

Takeishi S; Matsumoto A; Onoyama I; Naka K; Hirao A; Nakayama KI. 2013. Ablation of Fbxw7 eliminates leukemia-initiating cells by preventing quiescence. Cancer Cell 23(3):347-61. [PubMed: 23518349]  [MGI Ref ID J:197046]

Takeuchi O; Fisher J; Suh H; Harada H; Malynn BA; Korsmeyer SJ. 2005. Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease. Proc Natl Acad Sci U S A 102(32):11272-7. [PubMed: 16055554]  [MGI Ref ID J:100463]

Takubo K; Goda N; Yamada W; Iriuchishima H; Ikeda E; Kubota Y; Shima H; Johnson RS; Hirao A; Suematsu M; Suda T. 2010. Regulation of the HIF-1alpha level is essential for hematopoietic stem cells. Cell Stem Cell 7(3):391-402. [PubMed: 20804974]  [MGI Ref ID J:164436]

Takubo K; Nagamatsu G; Kobayashi CI; Nakamura-Ishizu A; Kobayashi H; Ikeda E; Goda N; Rahimi Y; Johnson RS; Soga T; Hirao A; Suematsu M; Suda T. 2013. Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells. Cell Stem Cell 12(1):49-61. [PubMed: 23290136]  [MGI Ref ID J:194930]

Tandon P; Gallo CA; Khatri S; Barger JF; Yepiskoposyan H; Plas DR. 2011. Requirement for ribosomal protein S6 kinase 1 to mediate glycolysis and apoptosis resistance induced by Pten deficiency. Proc Natl Acad Sci U S A 108(6):2361-5. [PubMed: 21262837]  [MGI Ref ID J:169097]

Tang F; Wu Q; Ikenoue T; Guan KL; Liu Y; Zheng P. 2012. A critical role for Rictor in T lymphopoiesis. J Immunol 189(4):1850-7. [PubMed: 22815285]  [MGI Ref ID J:189736]

Tang K; Rossiter HB; Wagner PD; Breen EC. 2004. Lung-targeted VEGF inactivation leads to an emphysema phenotype in mice. J Appl Physiol 97(4):1559-66; discussion 1549. [PubMed: 15208295]  [MGI Ref ID J:134576]

Tang M; Wei X; Guo Y; Breslin P; Zhang S; Zhang S; Wei W; Xia Z; Diaz M; Akira S; Zhang J. 2008. TAK1 is required for the survival of hematopoietic cells and hepatocytes in mice. J Exp Med 205(7):1611-9. [PubMed: 18573910]  [MGI Ref ID J:137388]

Tanigaki K; Han H; Yamamoto N; Tashiro K; Ikegawa M; Kuroda K; Suzuki A; Nakano T; Honjo T. 2002. Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells. Nat Immunol 3(5):443-50. [PubMed: 11967543]  [MGI Ref ID J:76240]

Taniguchi Ishikawa E; Chang KH; Nayak R; Olsson HA; Ficker AM; Dunn SK; Madhu MN; Sengupta A; Whitsett JA; Grimes HL; Cancelas JA. 2013. Klf5 controls bone marrow homing of stem cells and progenitors through Rab5-mediated beta1/beta2-integrin trafficking. Nat Commun 4:1660. [PubMed: 23552075]  [MGI Ref ID J:205746]

Tesio M; Oser GM; Baccelli I; Blanco-Bose W; Wu H; Gothert JR; Kogan SC; Trumpp A. 2013. Pten loss in the bone marrow leads to G-CSF-mediated HSC mobilization. J Exp Med 210(11):2337-49. [PubMed: 24127490]  [MGI Ref ID J:206536]

Thomas EK; Cancelas JA; Chae HD; Cox AD; Keller PJ; Perrotti D; Neviani P; Druker BJ; Setchell KD; Zheng Y; Harris CE; Williams DA. 2007. Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease. Cancer Cell 12(5):467-78. [PubMed: 17996650]  [MGI Ref ID J:127321]

Thompson BJ; Jankovic V; Gao J; Buonamici S; Vest A; Lee JM; Zavadil J; Nimer SD; Aifantis I. 2008. Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7. J Exp Med 205(6):1395-408. [PubMed: 18474632]  [MGI Ref ID J:137138]

Thomsen MK; Bakiri L; Hasenfuss SC; Hamacher R; Martinez L; Wagner EF. 2013. JUNB/AP-1 controls IFN-gamma during inflammatory liver disease. J Clin Invest 123(12):5258-68. [PubMed: 24200694]  [MGI Ref ID J:207773]

Thoren LA; Norgaard GA; Weischenfeldt J; Waage J; Jakobsen JS; Damgaard I; Bergstrom FC; Blom AM; Borup R; Bisgaard HC; Porse BT. 2010. UPF2 is a critical regulator of liver development, function and regeneration. PLoS One 5(7):e11650. [PubMed: 20657840]  [MGI Ref ID J:163097]

Tiedt R; Hao-Shen H; Sobas MA; Looser R; Dirnhofer S; Schwaller J; Skoda RC. 2008. Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice. Blood 111(8):3931-40. [PubMed: 18160670]  [MGI Ref ID J:134364]

Tivesten A; Bollano E; Andersson I; Fitzgerald S; Caidahl K; Sjogren K; Skott O; Liu JL; Mobini R; Isaksson OG; Jansson JO; Ohlsson C; Bergstrom G; Isgaard J. 2002. Liver-derived insulin-like growth factor-I is involved in the regulation of blood pressure in mice. Endocrinology 143(11):4235-42. [PubMed: 12399417]  [MGI Ref ID J:80468]

Tomita S; Sinal CJ; Yim SH; Gonzalez FJ. 2000. Conditional disruption of the aryl hydrocarbon receptor nuclear translocator (Arnt) gene leads to loss of target gene induction by the aryl hydrocarbon receptor and hypoxia-inducible factor 1alpha Mol Endocrinol 14(10):1674-81. [PubMed: 11043581]  [MGI Ref ID J:64967]

Torchia EC; Boyd K; Rehg JE; Qu C; Baker SJ. 2007. EWS/FLI-1 induces rapid onset of myeloid/erythroid leukemia in mice. Mol Cell Biol 27(22):7918-34. [PubMed: 17875932]  [MGI Ref ID J:129039]

Tothova Z; Kollipara R; Huntly BJ; Lee BH; Castrillon DH; Cullen DE; McDowell EP; Lazo-Kallanian S; Williams IR; Sears C; Armstrong SA; Passegue E; DePinho RA; Gilliland DG. 2007. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell 128(2):325-39. [PubMed: 17254970]  [MGI Ref ID J:117892]

Toubai T; Sun Y; Tawara I; Friedman A; Liu C; Evers R; Nieves E; Malter C; Chockley P; Maillard I; Winandy S; Reddy P. 2011. Ikaros-Notch axis in host hematopoietic cells regulates experimental graft-versus-host disease. Blood 118(1):192-204. [PubMed: 21471527]  [MGI Ref ID J:174908]

Trierweiler C; Blum HE; Hasselblatt P. 2012. The transcription factor c-Jun protects against liver damage following activated beta-Catenin signaling. PLoS One 7(7):e40638. [PubMed: 22792392]  [MGI Ref ID J:189640]

Tripathi P; Kurtulus S; Wojciechowski S; Sholl A; Hoebe K; Morris SC; Finkelman FD; Grimes HL; Hildeman DA. 2010. STAT5 is critical to maintain effector CD8+ T cell responses. J Immunol 185(4):2116-24. [PubMed: 20644163]  [MGI Ref ID J:162623]

Troadec MB; Warner D; Wallace J; Thomas K; Spangrude GJ; Phillips J; Khalimonchuk O; Paw BH; Ward DM; Kaplan J. 2011. Targeted deletion of the mouse Mitoferrin1 gene: from anemia to protoporphyria. Blood 117(20):5494-502. [PubMed: 21310927]  [MGI Ref ID J:173284]

Trowbridge JJ; Sinha AU; Zhu N; Li M; Armstrong SA; Orkin SH. 2012. Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains. Genes Dev 26(4):344-9. [PubMed: 22345515]  [MGI Ref ID J:181638]

Trowbridge JJ; Snow JW; Kim J; Orkin SH. 2009. DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells. Cell Stem Cell 5(4):442-9. [PubMed: 19796624]  [MGI Ref ID J:154111]

Trumpp A; Refaeli Y; Oskarsson T; Gasser S; Murphy M; Martin GR; Bishop JM. 2001. c-Myc regulates mammalian body size by controlling cell number but not cell size. Nature 414(6865):768-73. [PubMed: 11742404]  [MGI Ref ID J:73369]

Tsuji-Takechi K; Negishi-Koga T; Sumiya E; Kukita A; Kato S; Maeda T; Pandolfi PP; Moriyama K; Takayanagi H. 2012. Stage-specific functions of leukemia/lymphoma-related factor (LRF) in the transcriptional control of osteoclast development. Proc Natl Acad Sci U S A 109(7):2561-6. [PubMed: 22308398]  [MGI Ref ID J:182617]

Tze LE; Schram BR; Lam KP; Hogquist KA; Hippen KL; Liu J; Shinton SA; Otipoby KL; Rodine PR; Vegoe AL; Kraus M; Hardy RR; Schlissel MS; Rajewsky K; Behrens TW. 2005. Basal immunoglobulin signaling actively maintains developmental stage in immature B cells. PLoS Biol 3(3):e82. [PubMed: 15752064]  [MGI Ref ID J:133822]

Ulyanova T; Jiang Y; Padilla S; Nakamoto B; Papayannopoulou T. 2011. Combinatorial and distinct roles of alpha and alpha integrins in stress erythropoiesis in mice. Blood 117(3):975-85. [PubMed: 20956802]  [MGI Ref ID J:168417]

Ulyanova T; Priestley GV; Banerjee ER; Papayannopoulou T. 2007. Unique and redundant roles of alpha4 and beta2 integrins in kinetics of recruitment of lymphoid vs myeloid cell subsets to the inflamed peritoneum revealed by studies of genetically deficient mice. Exp Hematol 35(8):1256-65. [PubMed: 17553614]  [MGI Ref ID J:126483]

Ulyanova T; Priestley GV; Nakamoto B; Jiang Y; Papayannopoulou T. 2007. VCAM-1 ablation in nonhematopoietic cells in MxCre+ VCAM-1f/f mice is variable and dictates their phenotype. Exp Hematol 35(4):565-71. [PubMed: 17379066]  [MGI Ref ID J:123142]

Vahl JC; Heger K; Knies N; Hein MY; Boon L; Yagita H; Polic B; Schmidt-Supprian M. 2013. NKT cell-TCR expression activates conventional T cells in vivo, but is largely dispensable for mature NKT cell biology. PLoS Biol 11(6):e1001589. [PubMed: 23853545]  [MGI Ref ID J:201417]

Vallespinos M; Fernandez D; Rodriguez L; Alvaro-Blanco J; Baena E; Ortiz M; Dukovska D; Martinez D; Rojas A; Campanero MR; Moreno de Alboran I. 2011. B Lymphocyte commitment program is driven by the proto-oncogene c-Myc. J Immunol 186(12):6726-36. [PubMed: 21572027]  [MGI Ref ID J:175485]

Van Meter ME; Diaz-Flores E; Archard JA; Passegue E; Irish JM; Kotecha N; Nolan GP; Shannon K; Braun BS. 2007. K-RasG12D expression induces hyperproliferation and aberrant signaling in primary hematopoietic stem/progenitor cells. Blood 109(9):3945-52. [PubMed: 17192389]  [MGI Ref ID J:145335]

Vanoaica L; Richman L; Jaworski M; Darshan D; Luther SA; Kuhn LC. 2014. Conditional deletion of ferritin h in mice reduces B and T lymphocyte populations. PLoS One 9(2):e89270. [PubMed: 24586648]  [MGI Ref ID J:213756]

Varnum-Finney B; Halasz LM; Sun M; Gridley T; Radtke F; Bernstein ID. 2011. Notch2 governs the rate of generation of mouse long- and short-term repopulating stem cells. J Clin Invest 121(3):1207-16. [PubMed: 21285514]  [MGI Ref ID J:171820]

Vassiliou GS; Cooper JL; Rad R; Li J; Rice S; Uren A; Rad L; Ellis P; Andrews R; Banerjee R; Grove C; Wang W; Liu P; Wright P; Arends M; Bradley A. 2011. Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice. Nat Genet 43(5):470-5. [PubMed: 21441929]  [MGI Ref ID J:172071]

Vegiopoulos A; Garcia P; Emambokus N; Frampton J. 2006. Coordination of erythropoiesis by the transcription factor c-Myb. Blood 107(12):4703-10. [PubMed: 16484593]  [MGI Ref ID J:132864]

Velasco-Hernandez T; Hyrenius-Wittsten A; Rehn M; Bryder D; Cammenga J. 2014. HIF-1alpha can act as a tumor suppressor gene in murine acute myeloid leukemia. Blood 124(24):3597-607. [PubMed: 25267197]  [MGI Ref ID J:220797]

Vemula S; Ramdas B; Hanneman P; Martin J; Beggs HE; Kapur R. 2010. Essential role for focal adhesion kinase in regulating stress hematopoiesis. Blood 116(20):4103-15. [PubMed: 20664055]  [MGI Ref ID J:166470]

Ventura A; Young AG; Winslow MM; Lintault L; Meissner A; Erkeland SJ; Newman J; Bronson RT; Crowley D; Stone JR; Jaenisch R; Sharp PA; Jacks T. 2008. Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell 132(5):875-86. [PubMed: 18329372]  [MGI Ref ID J:134861]

Verdeguer F; Le Corre S; Fischer E; Callens C; Garbay S; Doyen A; Igarashi P; Terzi F; Pontoglio M. 2010. A mitotic transcriptional switch in polycystic kidney disease. Nat Med 16(1):106-10. [PubMed: 19966811]  [MGI Ref ID J:155869]

Viatour P; Somervaille TC; Venkatasubrahmanyam S; Kogan S; McLaughlin ME; Weissman IL; Butte AJ; Passegue E; Sage J. 2008. Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family. Cell Stem Cell 3(4):416-28. [PubMed: 18940733]  [MGI Ref ID J:149791]

Volarevic S; Stewart MJ; Ledermann B; Zilberman F; Terracciano L; Montini E; Grompe M; Kozma SC; Thomas G. 2000. Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6. Science 288(5473):2045-7. [PubMed: 10856218]  [MGI Ref ID J:62795]

Wada T; Stepniak E; Hui L; Leibbrandt A; Katada T; Nishina H; Wagner EF; Penninger JM. 2008. Antagonistic control of cell fates by JNK and p38-MAPK signaling. Cell Death Differ 15(1):89-93. [PubMed: 17762881]  [MGI Ref ID J:142173]

Wahlstrom AM; Cutts BA; Karlsson C; Andersson KM; Liu M; Sjogren AK; Swolin B; Young SG; Bergo MO. 2007. Rce1 deficiency accelerates the development of K-RAS-induced myeloproliferative disease. Blood 109(2):763-8. [PubMed: 16973961]  [MGI Ref ID J:143675]

Wahlstrom AM; Cutts BA; Liu M; Lindskog A; Karlsson C; Sjogren AK; Andersson KM; Young SG; Bergo MO. 2008. Inactivating Icmt ameliorates K-RAS-induced myeloproliferative disease. Blood 112(4):1357-65. [PubMed: 18502828]  [MGI Ref ID J:138426]

Walkley CR; Orkin SH. 2006. Rb is dispensable for self-renewal and multilineage differentiation of adult hematopoietic stem cells. Proc Natl Acad Sci U S A 103(24):9057-62. [PubMed: 16754850]  [MGI Ref ID J:111063]

Wallenius K; Sjogren K; Peng XD; Park S; Wallenius V; Liu JL; Umaerus M; Wennbo H; Isaksson O; Frohman L; Kineman R; Ohlsson C; Jansson JO. 2001. Liver-derived igf-i regulates gh secretion at the pituitary level in mice. Endocrinology 142(11):4762-70. [PubMed: 11606442]  [MGI Ref ID J:72793]

Walz C; Ahmed W; Lazarides K; Betancur M; Patel N; Hennighausen L; Zaleskas VM; Van Etten RA. 2012. Essential role for Stat5a/b in myeloproliferative neoplasms induced by BCR-ABL1 and JAK2(V617F) in mice. Blood 119(15):3550-60. [PubMed: 22234689]  [MGI Ref ID J:183819]

Wang CQ; Motoda L; Satake M; Ito Y; Taniuchi I; Tergaonkar V; Osato M. 2013. Runx3 deficiency results in myeloproliferative disorder in aged mice. Blood 122(4):562-6. [PubMed: 23741011]  [MGI Ref ID J:201784]

Wang J; Iwasaki H; Krivtsov A; Febbo PG; Thorner AR; Ernst P; Anastasiadou E; Kutok JL; Kogan SC; Zinkel SS; Fisher JK; Hess JL; Golub TR; Armstrong SA; Akashi K; Korsmeyer SJ. 2005. Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease. EMBO J 24(2):368-81. [PubMed: 15635450]  [MGI Ref ID J:95914]

Wang J; Kong G; Liu Y; Du J; Chang YI; Tey SR; Zhang X; Ranheim EA; Saba-El-Leil MK; Meloche S; Damnernsawad A; Zhang J; Zhang J. 2013. Nras(G12D/+) promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions. Blood 121(26):5203-7. [PubMed: 23687087]  [MGI Ref ID J:201009]

Wang J; Liu Y; Li Z; Du J; Ryu MJ; Taylor PR; Fleming MD; Young KH; Pitot H; Zhang J. 2010. Endogenous oncogenic Nras mutation promotes aberrant GM-CSF signaling in granulocytic/monocytic precursors in a murine model of chronic myelomonocytic leukemia. Blood 116(26):5991-6002. [PubMed: 20921338]  [MGI Ref ID J:167384]

Wang J; Liu Y; Li Z; Wang Z; Tan LX; Ryu MJ; Meline B; Du J; Young KH; Ranheim E; Chang Q; Zhang J. 2011. Endogenous oncogenic Nras mutation initiates hematopoietic malignancies in a dose- and cell type-dependent manner. Blood 118(2):368-79. [PubMed: 21586752]  [MGI Ref ID J:174880]

Wang L; Wang CM; Hou LH; Dou GR; Wang YC; Hu XB; He F; Feng F; Zhang HW; Liang YM; Dou KF; Han H. 2009. Disruption of the transcription factor recombination signal-binding protein-Jkappa (RBP-J) leads to veno-occlusive disease and interfered liver regeneration in mice. Hepatology 49(1):268-77. [PubMed: 19065680]  [MGI Ref ID J:153784]

Wang L; Wang YC; Hu XB; Zhang BF; Dou GR; He F; Gao F; Feng F; Liang YM; Dou KF; Han H. 2009. Notch-RBP-J signaling regulates the mobilization and function of endothelial progenitor cells by dynamic modulation of CXCR4 expression in mice. PLoS One 4(10):e7572. [PubMed: 19859544]  [MGI Ref ID J:154034]

Wang XD; Leow CC; Zha J; Tang Z; Modrusan Z; Radtke F; Aguet M; de Sauvage FJ; Gao WQ. 2006. Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation. Dev Biol 290(1):66-80. [PubMed: 16360140]  [MGI Ref ID J:104805]

Wang Y; Reheman A; Spring CM; Kalantari J; Marshall AH; Wolberg AS; Gross PL; Weitz JI; Rand ML; Mosher DF; Freedman J; Ni H. 2014. Plasma fibronectin supports hemostasis and regulates thrombosis. J Clin Invest 124(10):4281-93. [PubMed: 25180602]  [MGI Ref ID J:217640]

Wang Y; Wimmer U; Lichtlen P; Inderbitzin D; Stieger B; Meier PJ; Hunziker L; Stallmach T; Forrer R; Rulicke T; Georgiev O; Schaffner W. 2004. Metal-responsive transcription factor-1 (MTF-1) is essential for embryonic liver development and heavy metal detoxification in the adult liver. FASEB J 18(10):1071-9. [PubMed: 15226267]  [MGI Ref ID J:91119]

Wang YC; He F; Feng F; Liu XW; Dong GY; Qin HY; Hu XB; Zheng MH; Liang L; Feng L; Liang YM; Han H. 2010. Notch signaling determines the M1 versus M2 polarization of macrophages in antitumor immune responses. Cancer Res 70(12):4840-9. [PubMed: 20501839]  [MGI Ref ID J:160918]

Wang YC; Hu XB; He F; Feng F; Wang L; Li W; Zhang P; Li D; Jia ZS; Liang YM; Han H. 2009. Lipopolysaccharide-induced maturation of bone marrow-derived dendritic cells is regulated by notch signaling through the up-regulation of CXCR4. J Biol Chem 284(23):15993-6003. [PubMed: 19357083]  [MGI Ref ID J:150688]

Wang YH; Israelsen WJ; Lee D; Yu VW; Jeanson NT; Clish CB; Cantley LC; Vander Heiden MG; Scadden DT. 2014. Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesis. Cell 158(6):1309-23. [PubMed: 25215489]  [MGI Ref ID J:214948]

Wang Z; Li G; Tse W; Bunting KD. 2009. Conditional deletion of STAT5 in adult mouse hematopoietic stem cells causes loss of quiescence and permits efficient nonablative stem cell replacement. Blood 113(20):4856-65. [PubMed: 19258595]  [MGI Ref ID J:148957]

Waning DL; Li B; Jia N; Naaldijk Y; Goebel WS; HogenEsch H; Chun KT. 2008. Cul4A is required for hematopoietic cell viability and its deficiency leads to apoptosis. Blood 112(2):320-9. [PubMed: 18339895]  [MGI Ref ID J:138468]

Warr MR; Binnewies M; Flach J; Reynaud D; Garg T; Malhotra R; Debnath J; Passegue E. 2013. FOXO3A directs a protective autophagy program in haematopoietic stem cells. Nature 494(7437):323-7. [PubMed: 23389440]  [MGI Ref ID J:194535]

Weber BN; Chi AW; Chavez A; Yashiro-Ohtani Y; Yang Q; Shestova O; Bhandoola A. 2011. A critical role for TCF-1 in T-lineage specification and differentiation. Nature 476(7358):63-8. [PubMed: 21814277]  [MGI Ref ID J:174921]

Weber S; Wetzel S; Prox J; Lehmann T; Schneppenheim J; Donners M; Saftig P. 2013. Regulation of adult hematopoiesis by the a disintegrin and metalloproteinase 10 (ADAM10). Biochem Biophys Res Commun 442(3-4):234-41. [PubMed: 24239882]  [MGI Ref ID J:211494]

Wein MN; Jones DC; Shim JH; Aliprantis AO; Sulyanto R; Lazarevic V; Poliachik SL; Gross TS; Glimcher LH. 2012. Control of bone resorption in mice by Schnurri-3. Proc Natl Acad Sci U S A 109(21):8173-8. [PubMed: 22573816]  [MGI Ref ID J:184764]

Weischenfeldt J; Damgaard I; Bryder D; Theilgaard-Monch K; Thoren LA; Nielsen FC; Jacobsen SE; Nerlov C; Porse BT. 2008. NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements. Genes Dev 22(10):1381-96. [PubMed: 18483223]  [MGI Ref ID J:134765]

Welch JS; Yuan W; Ley TJ. 2011. PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice. J Clin Invest 121(4):1636-45. [PubMed: 21364283]  [MGI Ref ID J:172024]

Wells CM; Walmsley M; Ooi S; Tybulewicz V; Ridley AJ. 2004. Rac1-deficient macrophages exhibit defects in cell spreading and membrane ruffling but not migration. J Cell Sci 117(Pt 7):1259-68. [PubMed: 14996945]  [MGI Ref ID J:119419]

Welner RS; Bararia D; Amabile G; Czibere A; Benoukraf T; Bach C; Wansa KD; Ye M; Zhang H; Iino T; Hetherington CJ; Akashi K; Tenen DG. 2013. C/EBPalpha is required for development of dendritic cell progenitors. Blood 121(20):4073-81. [PubMed: 23547051]  [MGI Ref ID J:198203]

Wendorff AA; Koch U; Wunderlich FT; Wirth S; Dubey C; Bruning JC; MacDonald HR; Radtke F. 2010. Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation. Immunity 33(5):671-84. [PubMed: 21093323]  [MGI Ref ID J:167000]

Weng Z; Li D; Zhang L; Chen J; Ruan C; Chen G; Gartner TK; Liu J. 2010. PTEN regulates collagen-induced platelet activation. Blood 116(14):2579-81. [PubMed: 20554973]  [MGI Ref ID J:165893]

Wenzel J; Held C; Palmisano R; Teufel S; David JP; Wittenberg T; Lang R. 2011. Measurement of TLR-Induced Macrophage Spreading by Automated Image Analysis: Differential Role of Myd88 and MAPK in Early and Late Responses. Front Physiol 2:71. [PubMed: 22028692]  [MGI Ref ID J:177994]

Wey S; Luo B; Tseng CC; Ni M; Zhou H; Fu Y; Bhojwani D; Carroll WL; Lee AS. 2012. Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis and AKT oncogenic signaling. Blood 119(3):817-25. [PubMed: 21937694]  [MGI Ref ID J:181587]

Wiede F; La Gruta NL; Tiganis T. 2014. PTPN2 attenuates T-cell lymphopenia-induced proliferation. Nat Commun 5:3073. [PubMed: 24445916]  [MGI Ref ID J:206438]

Willis MS; Homeister JW; Rosson GB; Annayev Y; Holley D; Holly SP; Madden VJ; Godfrey V; Parise LV; Bultman SJ. 2012. Functional redundancy of SWI/SNF catalytic subunits in maintaining vascular endothelial cells in the adult heart. Circ Res 111(5):e111-22. [PubMed: 22740088]  [MGI Ref ID J:212652]

Wilson A; Ardiet DL; Saner C; Vilain N; Beermann F; Aguet M; Macdonald HR; Zilian O. 2007. Normal hemopoiesis and lymphopoiesis in the combined absence of numb and numblike. J Immunol 178(11):6746-51. [PubMed: 17513721]  [MGI Ref ID J:133550]

Wilson A; MacDonald HR; Radtke F. 2001. Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus. J Exp Med 194(7):1003-12. [PubMed: 11581321]  [MGI Ref ID J:119436]

Wilson A; Murphy MJ; Oskarsson T; Kaloulis K; Bettess MD; Oser GM; Pasche AC; Knabenhans C; Macdonald HR; Trumpp A. 2004. c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation. Genes Dev 18(22):2747-63. [PubMed: 15545632]  [MGI Ref ID J:93882]

Wilting RH; Yanover E; Heideman MR; Jacobs H; Horner J; van der Torre J; DePinho RA; Dannenberg JH. 2010. Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis. EMBO J 29(15):2586-97. [PubMed: 20571512]  [MGI Ref ID J:197818]

Wimmer U; Wang Y; Georgiev O; Schaffner W. 2005. Two major branches of anti-cadmium defense in the mouse: MTF-1/metallothioneins and glutathione. Nucleic Acids Res 33(18):5715-27. [PubMed: 16221973]  [MGI Ref ID J:102512]

Wirth KG; Ricci R; Gimenez-Abian JF; Taghybeeglu S; Kudo NR; Jochum W; Vasseur-Cognet M; Nasmyth K. 2004. Loss of the anaphase-promoting complex in quiescent cells causes unscheduled hepatocyte proliferation. Genes Dev 18(1):88-98. [PubMed: 14724179]  [MGI Ref ID J:87782]

Wirth KG; Wutz G; Kudo NR; Desdouets C; Zetterberg A; Taghybeeglu S; Seznec J; Ducos GM; Ricci R; Firnberg N; Peters JM; Nasmyth K. 2006. Separase: a universal trigger for sister chromatid disjunction but not chromosome cycle progression. J Cell Biol 172(6):847-60. [PubMed: 16533945]  [MGI Ref ID J:107916]

Wong CC; Martincorena I; Rust AG; Rashid M; Alifrangis C; Alexandrov LB; Tiffen JC; Kober C; Green AR; Massie CE; Nangalia J; Lempidaki S; Dohner H; Dohner K; Bray SJ; McDermott U; Papaemmanuil E; Campbell PJ; Adams DJ. 2014. Inactivating CUX1 mutations promote tumorigenesis. Nat Genet 46(1):33-8. [PubMed: 24316979]  [MGI Ref ID J:205497]

Wong JC; Zhang Y; Lieuw KH; Tran MT; Forgo E; Weinfurtner K; Alzamora P; Kogan SC; Akagi K; Wolff L; Le Beau MM; Killeen N; Shannon K. 2010. Use of chromosome engineering to model a segmental deletion of chromosome band 7q22 found in myeloid malignancies. Blood 115(22):4524-32. [PubMed: 20233966]  [MGI Ref ID J:161558]

Wong SH; Walker JA; Jolin HE; Drynan LF; Hams E; Camelo A; Barlow JL; Neill DR; Panova V; Koch U; Radtke F; Hardman CS; Hwang YY; Fallon PG; McKenzie AN. 2012. Transcription factor RORalpha is critical for nuocyte development. Nat Immunol 13(3):229-36. [PubMed: 22267218]  [MGI Ref ID J:181284]

Woodland RT; Fox CJ; Schmidt MR; Hammerman PS; Opferman JT; Korsmeyer SJ; Hilbert DM; Thompson CB. 2008. Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survival. Blood 111(2):750-60. [PubMed: 17942753]  [MGI Ref ID J:130058]

Wu X; Yamamoto M; Akira S; Sun SC. 2009. Regulation of hematopoiesis by the K63-specific ubiquitin-conjugating enzyme Ubc13. Proc Natl Acad Sci U S A :. [PubMed: 19926860]  [MGI Ref ID J:155549]

Wuestefeld T; Klein C; Streetz KL; Beraza N; Scholmerich J; Burgart LJ; Zender L; Kubicka S; Baskin-Bey E; Gores GJ; Manns MP; Trautwein C. 2005. Lack of gp130 expression results in more bacterial infection and higher mortality during chronic cholestasis in mice. Hepatology 42(5):1082-90. [PubMed: 16250046]  [MGI Ref ID J:191185]

Wuestefeld T; Klein C; Streetz KL; Betz U; Lauber J; Buer J; Manns MP; Muller W; Trautwein C. 2003. Interleukin-6/glycoprotein 130-dependent pathways are protective during liver regeneration. J Biol Chem 278(13):11281-8. [PubMed: 12509437]  [MGI Ref ID J:91064]

Xiang Z; Luo H; Payton JE; Cain J; Ley TJ; Opferman JT; Tomasson MH. 2010. Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia. J Clin Invest 120(6):2109-18. [PubMed: 20484815]  [MGI Ref ID J:161639]

Xiao N; Jani K; Morgan K; Okabe R; Cullen DE; Jesneck JL; Raffel GD. 2012. Hematopoietic stem cells lacking Ott1 display aspects associated with aging and are unable to maintain quiescence during proliferative stress. Blood 119(21):4898-907. [PubMed: 22490678]  [MGI Ref ID J:185157]

Xiao Y; Li H; Zhang J; Volk A; Zhang S; Wei W; Zhang S; Breslin P; Zhang J. 2011. TNF-alpha/Fas-RIP-1-induced cell death signaling separates murine hematopoietic stem cells/progenitors into 2 distinct populations. Blood 118(23):6057-67. [PubMed: 21989986]  [MGI Ref ID J:179087]

Xie H; Xu J; Hsu JH; Nguyen M; Fujiwara Y; Peng C; Orkin SH. 2014. Polycomb repressive complex 2 regulates normal hematopoietic stem cell function in a developmental-stage-specific manner. Cell Stem Cell 14(1):68-80. [PubMed: 24239285]  [MGI Ref ID J:205522]

Xie J; Wang W; Si JW; Miao XY; Li JC; Wang YC; Wang ZR; Ma J; Zhao XC; Li Z; Yi H; Han H. 2013. Notch signaling regulates CXCR4 expression and the migration of mesenchymal stem cells. Cell Immunol 281(1):68-75. [PubMed: 23474530]  [MGI Ref ID J:194910]

Xin H; Lu R; Lee H; Zhang W; Zhang C; Deng J; Liu Y; Shen S; Wagner KU; Forman S; Jove R; Yu H. 2013. G-protein-coupled receptor agonist BV8/prokineticin-2 and STAT3 protein form a feed-forward loop in both normal and malignant myeloid cells. J Biol Chem 288(19):13842-9. [PubMed: 23548897]  [MGI Ref ID J:198587]

Xu D; Liu X; Yu WM; Meyerson HJ; Guo C; Gerson SL; Qu CK. 2011. Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells. J Exp Med 208(10):1977-88. [PubMed: 21930766]  [MGI Ref ID J:177285]

Xu J; Bauer DE; Kerenyi MA; Vo TD; Hou S; Hsu YJ; Yao H; Trowbridge JJ; Mandel G; Orkin SH. 2013. Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A. Proc Natl Acad Sci U S A 110(16):6518-23. [PubMed: 23576758]  [MGI Ref ID J:196140]

Xu J; Haigis KM; Firestone AJ; McNerney ME; Li Q; Davis E; Chen SC; Nakitandwe J; Downing J; Jacks T; Le Beau MM; Shannon K. 2013. Dominant role of oncogene dosage and absence of tumor suppressor activity in Nras-driven hematopoietic transformation. Cancer Discov 3(9):993-1001. [PubMed: 23733505]  [MGI Ref ID J:204263]

Xu J; Peng C; Sankaran VG; Shao Z; Esrick EB; Chong BG; Ippolito GC; Fujiwara Y; Ebert BL; Tucker PW; Orkin SH. 2011. Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing. Science 334(6058):993-6. [PubMed: 21998251]  [MGI Ref ID J:177861]

Xu S; Liu X; Bao Y; Zhu X; Han C; Zhang P; Zhang X; Li W; Cao X. 2012. Constitutive MHC class I molecules negatively regulate TLR-triggered inflammatory responses via the Fps-SHP-2 pathway. Nat Immunol 13(6):551-9. [PubMed: 22522491]  [MGI Ref ID J:186456]

Xu W; Fukuyama T; Ney PA; Wang D; Rehg J; Boyd K; van Deursen JM; Brindle PK. 2006. Global transcriptional coactivators CREB-binding protein and p300 are highly essential collectively but not individually in peripheral B cells. Blood 107(11):4407-16. [PubMed: 16424387]  [MGI Ref ID J:123532]

Xu Y; Swartz KL; Siu KT; Bhattacharyya M; Minella AC. 2014. Fbw7-dependent cyclin E regulation ensures terminal maturation of bone marrow erythroid cells by restraining oxidative metabolism. Oncogene 33(24):3161-71. [PubMed: 23873023]  [MGI Ref ID J:212621]

Xue L; Pulikkan JA; Valk PJ; Castilla LH. 2014. NrasG12D oncoprotein inhibits apoptosis of preleukemic cells expressing Cbfbeta-SMMHC via activation of MEK/ERK axis. Blood 124(3):426-36. [PubMed: 24894773]  [MGI Ref ID J:214458]

Yamada T; Kurosaki T; Hikida M. 2008. Essential roles of mgcRacGAP in multilineage differentiation and survival of murine hematopoietic cells. Biochem Biophys Res Commun 372(4):941-6. [PubMed: 18541143]  [MGI Ref ID J:137760]

Yamaji S; Zhang M; Zhang J; Endo Y; Bibikova E; Goff SP; Cang Y. 2010. Hepatocyte-specific deletion of DDB1 induces liver regeneration and tumorigenesis. Proc Natl Acad Sci U S A 107(51):22237-42. [PubMed: 21135245]  [MGI Ref ID J:167296]

Yamasaki N; Miyazaki K; Nagamachi A; Koller R; Oda H; Miyazaki M; Sasaki T; Honda ZI; Wolff L; Inaba T; Honda H. 2010. Identification of Zfp521/ZNF521 as a cooperative gene for E2A-HLF to develop acute B-lineage leukemia. Oncogene 29(13):1963-75. [PubMed: 20062079]  [MGI Ref ID J:160392]

Yamashita M; Nitta E; Nagamatsu G; Ikushima YM; Hosokawa K; Arai F; Suda T. 2013. Nucleostemin is indispensable for the maintenance and genetic stability of hematopoietic stem cells. Biochem Biophys Res Commun 441(1):196-201. [PubMed: 24140061]  [MGI Ref ID J:211519]

Yamazaki S; Ema H; Karlsson G; Yamaguchi T; Miyoshi H; Shioda S; Taketo MM; Karlsson S; Iwama A; Nakauchi H. 2011. Nonmyelinating schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche. Cell 147(5):1146-58. [PubMed: 22118468]  [MGI Ref ID J:178929]

Yan D; Hutchison RE; Mohi G. 2012. Critical requirement for Stat5 in a mouse model of polycythemia vera. Blood 119(15):3539-49. [PubMed: 22144185]  [MGI Ref ID J:183821]

Yang J; Croniger CM; Lekstrom-Himes J; Zhang P; Fenyus M; Tenen DG; Darlington GJ; Hanson RW. 2005. Metabolic response of mice to a postnatal ablation of CCAAT/enhancer-binding protein alpha. J Biol Chem 280(46):38689-99. [PubMed: 16166091]  [MGI Ref ID J:103822]

Yang L; Wang L; Geiger H; Cancelas JA; Mo J; Zheng Y. 2007. Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow. Proc Natl Acad Sci U S A 104(12):5091-6. [PubMed: 17360364]  [MGI Ref ID J:120090]

Yang L; Wang L; Kalfa TA; Cancelas JA; Shang X; Pushkaran S; Mo J; Williams DA; Zheng Y. 2007. Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis. Blood 110(12):3853-61. [PubMed: 17702896]  [MGI Ref ID J:149106]

Yang P; An H; Liu X; Wen M; Zheng Y; Rui Y; Cao X. 2010. The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway. Nat Immunol 11(6):487-94. [PubMed: 20453844]  [MGI Ref ID J:160697]

Yang Q; Monticelli LA; Saenz SA; Chi AW; Sonnenberg GF; Tang J; De Obaldia ME; Bailis W; Bryson JL; Toscano K; Huang J; Haczku A; Pear WS; Artis D; Bhandoola A. 2013. T cell factor 1 is required for group 2 innate lymphoid cell generation. Immunity 38(4):694-704. [PubMed: 23601684]  [MGI Ref ID J:196648]

Yang S; Li YP; Liu T; He X; Yuan X; Li C; Cao J; Kim Y. 2013. Mx1-Cre mediated Rgs12 conditional knockout mice exhibit increased bone mass phenotype. Genesis 51(3):201-9. [PubMed: 23349096]  [MGI Ref ID J:194057]

Yang XO; Zhang H; Kim BS; Niu X; Peng J; Chen Y; Kerketta R; Lee YH; Chang SH; Corry DB; Wang D; Watowich SS; Dong C. 2013. The signaling suppressor CIS controls proallergic T cell development and allergic airway inflammation. Nat Immunol 14(7):732-40. [PubMed: 23727894]  [MGI Ref ID J:204829]

Yang ZF; Drumea K; Cormier J; Wang J; Zhu X; Rosmarin AG. 2011. GABP transcription factor is required for myeloid differentiation, in part, through its control of Gfi-1 expression. Blood 118(8):2243-53. [PubMed: 21705494]  [MGI Ref ID J:176911]

Yang ZF; Zhang H; Ma L; Peng C; Chen Y; Wang J; Green MR; Li S; Rosmarin AG. 2013. GABP transcription factor is required for development of chronic myelogenous leukemia via its control of PRKD2. Proc Natl Acad Sci U S A 110(6):2312-7. [PubMed: 23345428]  [MGI Ref ID J:194335]

Yao D; Huang Y; Huang X; Wang W; Yan Q; Wei L; Xin W; Gerson S; Stanley P; Lowe JB; Zhou L. 2011. Protein O-fucosyltransferase 1 (Pofut1) regulates lymphoid and myeloid homeostasis through modulation of Notch receptor ligand interactions. Blood 117(21):5652-62. [PubMed: 21464368]  [MGI Ref ID J:173256]

Yao H; Goldman DC; Nechiporuk T; Kawane S; McWeeney SK; Tyner JW; Fan G; Kerenyi MA; Orkin SH; Fleming WH; Mandel G. 2014. Corepressor Rcor1 is essential for murine erythropoiesis. Blood 123(20):3175-84. [PubMed: 24652990]  [MGI Ref ID J:211681]

Yasuda T; Sanjo H; Pages G; Kawano Y; Karasuyama H; Pouyssegur J; Ogata M; Kurosaki T. 2008. Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion. Immunity 28(4):499-508. [PubMed: 18356083]  [MGI Ref ID J:134528]

Yazdanpanah B; Wiegmann K; Tchikov V; Krut O; Pongratz C; Schramm M; Kleinridders A; Wunderlich T; Kashkar H; Utermohlen O; Bruning JC; Schutze S; Kronke M. 2009. Riboflavin kinase couples TNF receptor 1 to NADPH oxidase. Nature 460(7259):1159-63. [PubMed: 19641494]  [MGI Ref ID J:151999]

Ye M; Zhang H; Amabile G; Yang H; Staber PB; Zhang P; Levantini E; Alberich-Jorda M; Zhang J; Kawasaki A; Tenen DG. 2013. C/EBPa controls acquisition and maintenance of adult haematopoietic stem cell quiescence. Nat Cell Biol 15(4):385-94. [PubMed: 23502316]  [MGI Ref ID J:197635]

Ye P; Liu Y; Chen C; Tang F; Wu Q; Wang X; Liu CG; Liu X; Liu R; Liu Y; Zheng P. 2015. An mTORC1-Mdm2-Drosha axis for miRNA biogenesis in response to glucose- and amino acid-deprivation. Mol Cell 57(4):708-20. [PubMed: 25639470]  [MGI Ref ID J:219960]

Yeligar SM; Machida K; Kalra VK. 2010. Ethanol-induced HO-1 and NQO1 are differentially regulated by HIF-1alpha and Nrf2 to attenuate inflammatory cytokine expression. J Biol Chem 285(46):35359-73. [PubMed: 20833713]  [MGI Ref ID J:166863]

Yeligar SM; Machida K; Tsukamoto H; Kalra VK. 2009. Ethanol augments RANTES/CCL5 expression in rat liver sinusoidal endothelial cells and human endothelial cells via activation of NF-kappa B, HIF-1 alpha, and AP-1. J Immunol 183(9):5964-76. [PubMed: 19828633]  [MGI Ref ID J:156806]

Yildiz Y; Hoffmann P; Vom Dahl S; Breiden B; Sandhoff R; Niederau C; Horwitz M; Karlsson S; Filocamo M; Elstein D; Beck M; Sandhoff K; Mengel E; Gonzalez MC; Nothen MM; Sidransky E; Zimran A; Mattheisen M. 2013. Functional and genetic characterization of the non-lysosomal glucosylceramidase 2 as a modifier for Gaucher disease. Orphanet J Rare Dis 8(1):151. [PubMed: 24070122]  [MGI Ref ID J:202681]

Yilmaz OH; Valdez R; Theisen BK; Guo W; Ferguson DO; Wu H; Morrison SJ. 2006. Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature 441(7092):475-82. [PubMed: 16598206]  [MGI Ref ID J:109085]

Yoda M; Kimura T; Tohmonda T; Uchikawa S; Koba T; Takito J; Morioka H; Matsumoto M; Link DC; Chiba K; Okada Y; Toyama Y; Horiuchi K. 2011. Dual functions of cell-autonomous and non-cell-autonomous ADAM10 activity in granulopoiesis. Blood 118(26):6939-42. [PubMed: 22042698]  [MGI Ref ID J:179060]

Yoshida T; Hazan I; Zhang J; Ng SY; Naito T; Snippert HJ; Heller EJ; Qi X; Lawton LN; Williams CJ; Georgopoulos K. 2008. The role of the chromatin remodeler Mi-2beta in hematopoietic stem cell self-renewal and multilineage differentiation. Genes Dev 22(9):1174-89. [PubMed: 18451107]  [MGI Ref ID J:134655]

Yoshitaka T; Mukai T; Kittaka M; Alford LM; Masrani S; Ishida S; Yamaguchi K; Yamada M; Mizuno N; Olsen BR; Reichenberger EJ; Ueki Y. 2014. Enhanced TLR-MYD88 signaling stimulates autoinflammation in SH3BP2 cherubism mice and defines the etiology of cherubism. Cell Rep 8(6):1752-66. [PubMed: 25220465]  [MGI Ref ID J:218550]

Youn JI; Kumar V; Collazo M; Nefedova Y; Condamine T; Cheng P; Villagra A; Antonia S; McCaffrey JC; Fishman M; Sarnaik A; Horna P; Sotomayor E; Gabrilovich DI. 2013. Epigenetic silencing of retinoblastoma gene regulates pathologic differentiation of myeloid cells in cancer. Nat Immunol 14(3):211-20. [PubMed: 23354483]  [MGI Ref ID J:193480]

Yu WM; Liu X; Shen J; Jovanovic O; Pohl EE; Gerson SL; Finkel T; Broxmeyer HE; Qu CK. 2013. Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation. Cell Stem Cell 12(1):62-74. [PubMed: 23290137]  [MGI Ref ID J:194929]

Yumimoto K; Akiyoshi S; Ueo H; Sagara Y; Onoyama I; Ueo H; Ohno S; Mori M; Mimori K; Nakayama KI. 2015. F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner. J Clin Invest 125(2):621-35. [PubMed: 25555218]  [MGI Ref ID J:220397]

Zhang H; Alberich-Jorda M; Amabile G; Yang H; Staber PB; Diruscio A; Welner RS; Ebralidze A; Zhang J; Levantini E; Lefebvre V; Valk PJ; Delwel R; Hoogenkamp M; Nerlov C; Cammenga J; Saez B; Scadden DT; Bonifer C; Ye M; Tenen DG. 2013. Sox4 is a key oncogenic target in C/EBPalpha mutant acute myeloid leukemia. Cancer Cell 24(5):575-88. [PubMed: 24183681]  [MGI Ref ID J:206602]

Zhang J; Grindley JC; Yin T; Jayasinghe S; He XC; Ross JT; Haug JS; Rupp D; Porter-Westpfahl KS; Wiedemann LM; Wu H; Li L. 2006. PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention. Nature 441(7092):518-22. [PubMed: 16633340]  [MGI Ref ID J:109084]

Zhang J; Wang J; Liu Y; Sidik H; Young KH; Lodish HF; Fleming MD. 2009. Oncogenic Kras-induced leukemogeneis: hematopoietic stem cells as the initial target and lineage-specific progenitors as the potential targets for final leukemic transformation. Blood 113(6):1304-14. [PubMed: 19066392]  [MGI Ref ID J:145536]

Zhang J; Xiao Y; Guo Y; Breslin P; Zhang S; Wei W; Zhang Z; Zhang J. 2011. Differential requirements for c-Myc in chronic hematopoietic hyperplasia and acute hematopoietic malignancies in Pten-null mice. Leukemia 25(12):1857-68. [PubMed: 21926961]  [MGI Ref ID J:178782]

Zhang P; Iwasaki-Arai J; Iwasaki H; Fenyus ML; Dayaram T; Owens BM; Shigematsu H; Levantini E; Huettner CS; Lekstrom-Himes JA; Akashi K; Tenen DG. 2004. Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alpha. Immunity 21(6):853-63. [PubMed: 15589173]  [MGI Ref ID J:94682]

Zhang S; Han CH; Chen XS; Zhang M; Xu LM; Zhang JJ; Xia Q. 2012. Transient ureteral obstruction prevents against kidney ischemia/reperfusion injury via hypoxia-inducible factor (HIF)-2alpha activation. PLoS One 7(1):e29876. [PubMed: 22295069]  [MGI Ref ID J:222349]

Zhang T; Liu S; Yang P; Han C; Wang J; Liu J; Han Y; Yu Y; Cao X. 2009. Fibronectin maintains survival of mouse natural killer (NK) cells via CD11b/Src/beta-catenin pathway. Blood 114(19):4081-8. [PubMed: 19738028]  [MGI Ref ID J:154182]

Zhang Y; Hu T; Hua C; Gu J; Zhang L; Hao S; Liang H; Wang X; Wang W; Xu J; Liu H; Liu B; Cheng T; Yuan W. 2014. Rictor is required for early B cell development in bone marrow. PLoS One 9(8):e103970. [PubMed: 25084011]  [MGI Ref ID J:218993]

Zhang Y; Ma X. 2010. Triptolide inhibits IL-12/IL-23 expression in APCs via CCAAT/enhancer-binding protein alpha. J Immunol 184(7):3866-77. [PubMed: 20194724]  [MGI Ref ID J:160081]

Zhang Y; Wang J; Wheat J; Chen X; Jin S; Sadrzadeh H; Fathi AT; Peterson RT; Kung AL; Sweetser DA; Yeh JR. 2013. AML1-ETO mediates hematopoietic self-renewal and leukemogenesis through a COX/beta-catenin signaling pathway. Blood 121(24):4906-16. [PubMed: 23645839]  [MGI Ref ID J:198932]

Zhang Y; Wong J; Klinger M; Tran MT; Shannon KM; Killeen N. 2009. MLL5 contributes to hematopoietic stem cell fitness and homeostasis. Blood 113(7):1455-63. [PubMed: 18818388]  [MGI Ref ID J:145449]

Zhang Z; Zhou L; Yang X; Wang Y; Zhang P; Hou L; Hu X; Xing Y; Liu Y; Li W; Han H. 2012. Notch-RBP-J-independent marginal zone B cell development in IgH transgenic mice with VH derived from a natural polyreactive antibody. PLoS One 7(6):e38894. [PubMed: 22719978]  [MGI Ref ID J:222344]

Zhao B; Grimes SN; Li S; Hu X; Ivashkiv LB. 2012. TNF-induced osteoclastogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J. J Exp Med 209(2):319-34. [PubMed: 22249448]  [MGI Ref ID J:181699]

Zhao L; Melenhorst JJ; Alemu L; Kirby M; Anderson S; Kench M; Hoogstraten-Miller S; Brinster L; Kamikubo Y; Gilliland DG; Liu PP. 2012. KIT with D816 mutations cooperates with CBFB-MYH11 for leukemogenesis in mice. Blood 119(6):1511-21. [PubMed: 22160378]  [MGI Ref ID J:181735]

Zhao M; Ross JT; Itkin T; Perry JM; Venkatraman A; Haug JS; Hembree MJ; Deng CX; Lapidot T; He XC; Li L. 2012. FGF signaling facilitates postinjury recovery of mouse hematopoietic system. Blood 120(9):1831-42. [PubMed: 22802336]  [MGI Ref ID J:189159]

Zhao Z; Zuber J; Diaz-Flores E; Lintault L; Kogan SC; Shannon K; Lowe SW. 2010. p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal. Genes Dev 24(13):1389-402. [PubMed: 20595231]  [MGI Ref ID J:161357]

Zhou BO; Ding L; Morrison SJ. 2015. Hematopoietic stem and progenitor cells regulate the regeneration of their niche by secreting Angiopoietin-1. Elife 4:. [PubMed: 25821987]  [MGI Ref ID J:220459]

Zhou X; Florian MC; Arumugam P; Chen X; Cancelas JA; Lang R; Malik P; Geiger H; Zheng Y. 2013. RhoA GTPase controls cytokinesis and programmed necrosis of hematopoietic progenitors. J Exp Med 210(11):2371-85. [PubMed: 24101377]  [MGI Ref ID J:204586]

Zhu HH; Ji K; Alderson N; He Z; Li S; Liu W; Zhang DE; Li L; Feng GS. 2011. Kit-Shp2-Kit signaling acts to maintain a functional hematopoietic stem and progenitor cell pool. Blood 117(20):5350-61. [PubMed: 21450902]  [MGI Ref ID J:177959]

Zimmer J; Ioannidis V; Held W. 2001. H-2D ligand expression by Ly49A+ natural killer (NK) cells precludes ligand uptake from environmental cells: implications for NK cell function. J Exp Med 194(10):1531-9. [PubMed: 11714759]  [MGI Ref ID J:108568]

Zingarelli B; Fan H; Ashton S; Piraino G; Mangeshkar P; Cook JA. 2008. Peroxisome proliferator activated receptor gamma is not necessary for the development of LPS-induced tolerance in macrophages. Immunology 124(1):51-7. [PubMed: 18028370]  [MGI Ref ID J:136454]

de la Roche M; Ritter AT; Angus KL; Dinsmore C; Earnshaw CH; Reiter JF; Griffiths GM. 2013. Hedgehog signaling controls T cell killing at the immunological synapse. Science 342(6163):1247-50. [PubMed: 24311692]  [MGI Ref ID J:205261]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandrySeveral strains contribute to the genetic background of this mutant mouse. Contributions from C57BL/6, CBA, 129S7/SvEvBrd-Hprtb-m2 and 129S4/SvJae are noted.Expected Coat color: Black and White Bellied Agouti.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

Pricing for USA, Canada and Mexico shipping destinations View International Pricing


Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2625.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $1725.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing


Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3412.50
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $2242.50

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use

General Terms and Conditions

For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.
- Use of MICE by companies or for-profit entities requires a license.

Contact information

General inquiries regarding Terms of Use

Contracts Administration


JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty


In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.