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These transgenic mice express the mouse alpha-chain and beta-chain T cell receptor that pairs with the CD4 coreceptor and is specific for chicken ovalbumin 323-339 in the context of I-A b. In these mice there is a four-fold increase in the CD4 to CD8 peripheral T cell ratio, and lymph node T cells demonstrate a dose-dependent proliferative response to the specific ovalbumin ligand. These transgenic mice are useful for studying in vivo T cell biology such as TCR-ligand interactions, T cell activation, thymic selection, cross-presentation of antigens, process of thymic selection and central and peripheral T cell tolerance and induction.


Strain Information

Former Names C57BL/6-Tg(TcraTcrb)425Cbn/J    (Changed: 09-APR-10 )
Type Congenic; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Breeding Considerations This strain is a good breeder.
Specieslaboratory mouse
H2 Haplotypeb
GenerationN4F?N3F10pF3 (14-AUG-14)
Generation Definitions
Donating Investigator Frank Carbone,   University of Melbourne

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These transgenic mice express the mouse alpha-chain and beta-chain T cell receptor that pairs with the CD4 coreceptor and is specific for chicken ovalbumin 323-339 in the context of I-A b. Homozygous mice are viable and fertile. In these mice there is a four-fold increase in the CD4 to CD8 peripheral T cell ratio, and lymph node T cells demonstrate a dose-dependent proliferative response to the specific ovalbumin ligand. These transgenic mice are useful for studying in vivo T cell biology such as TCR-ligand interactions, T cell activation, thymic selection, cross-presentation of antigens, process of thymic selection and central and peripheral T cell tolerance and induction.

Transgenic constructs containing the alpha-chain and beta-chain of the T-cell receptor from a T cell hybridoma clone including the endogenous TCR promoter were coinjected into fertilized B6 x B6.C-H2bm1 mouse eggs. The T cell hybridoma clone is CD4+, MHC class II-restricted and is specific for the ovalbumin residue 323-339 peptides in the context of the MHC class II I-A2 molecule. Founder animals (described as OT-II.2 subline 425-2) were bred to wild-type B6 mice.

Control Information

   000664 C57BL/6J
  Considerations for Choosing Controls

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005895   B10.Cg-Thy1a H2d Tg(TcraCl1,TcrbCl1)1Shrm/J
002761   B10.Cg-Tg(TcrAND)53Hed/J
003147   B10.D2-Hc1 H2d H2-T18c/nSnJ-Tg(DO11.10)10Dlo/J
003199   B10.PL-H2u H2-T18a/(73NS)Sn-Tg(TCRA)B1Jg/J
002116   B6.129S2-Tcratm1Mom/J
008684   B6.Cg-Rag1tm1Mom Tyrp1B-w Tg(Tcra,Tcrb)9Rest/J
014550   B6.Cg-Thy1a Tg(TcraCWM5,TcrbCWM5)1807Wuth/J
005023   B6.Cg-Thy1a/Cy Tg(TcraTcrb)8Rest/J
005655   B6.Cg-Tg(Tcra,Tcrb)3Ayr/J
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008429   B6.Cg-Tg(Tcra,Tcrb)HRVAll/J
008006   B6.Cg-Tg(Tcra51-11.5,Tcrb51-11.5)AR206Ayr/J
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002115   B6;129S2-Tcratm1Mom/J
004694   B6;D2-Tg(TcrLCMV)327Sdz/JDvsJ
002408   B6;SJL-Tg(TcrAND)53Hed/J
007848   BXSB.129P2(Cg)-Tcratm1Mjo/TheoJ
021880   BXSB.B6-Tg(TcraTcrb)1100Mjb/DcrJ
004364   C.Cg-Tcratm1Mom Tcrbtm1Mom/J
003303   C.Cg-Tg(DO11.10)10Dlo/J
002045   C.SJL-Tcrac/SlkJ
002047   C.SJL-Tcrba Tcrac/SlkJ
014639   C57BL/6-Tg(Cd4-TcraDN32D3)1Aben/J
011005   C57BL/6-Tg(H2-Kb-Tcra,-Tcrb)P25Ktk/J
026970   C57BL/6-Tg(Tcra,Tcrb)1Litt/J
006912   C57BL/6-Tg(Tcra2D2,Tcrb2D2)1Kuch/J
003831   C57BL/6-Tg(TcraTcrb)1100Mjb/J
027230   C57BL/6J-Tg(Tcra,Tcrb)2Litt/J
005307   CBy.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005922   CBy.Cg-Thy1a Tg(TcraCl1,TcrbCl1)1Shrm/J
005694   D1Lac.Cg-Tg(Tcra,Tcrb)24Efro/J
017314   NOD-Tg(TcraTcrb)2H6Lwn/J
004444   NOD.129P2(C)-Tcratm1Mjo/DoiJ
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026243   NOD.Cg-(D9rs4135590-D9rs13480186)H2k2Tg(ILK3mHEL)3Ccg Tg(TcrHEL3A9)1Mmd/SlsgJ
026624   NOD.Cg-(D9rs6385855-D9rs13480186)H2k2Tg(ILK3mHEL)3Ccg Tg(TcrHEL3A9)1Mmd/SlsgJ
004257   NOD.Cg-Prkdcscid Tg(TcrLCMV)327Sdz/DvsJ
004347   NOD.Cg-Rag1tm1Mom Tg(TcraAI4)1Dvs/DvsJ
009377   NOD.Cg-Rag1tm1Mom Tg(TcraBDC12-4.1)10Jos Tg(TcrbBDC12-4.1)82Gse/J
024476   NOD.Cg-Stat4tm1Gru Thy1a Ifngr1tm1Agt Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/LmbrJ
005686   NOD.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
004696   NOD.Cg-Tg(TcrLCMV)327Sdz/DvsJ
004460   NOD.Cg-Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/DoiJ
010526   NOD.Cg-Tg(TcraTcrbNY4.1)1Pesa/DvsJ
005868   NOD.Cg-Tg(TcraTcrbNY8.3)1Pesa/DvsJ
006303   NOD.FVB-Tg(TcraBDC12-4.1)10Jos/GseJ
004334   NOD/ShiLt-Tg(TcraAI4)1Dvs
018030   SJL.Cg-Tg(TcraTcrbVP2)1Bkim/J
002597   STOCK Tg(TcrHEL3A9)1Mmd/J
View Strains carrying other alleles of Tcra     (51 strains)

Strains carrying other alleles of Tcrb
005308   B10.Cg-H2d Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005895   B10.Cg-Thy1a H2d Tg(TcraCl1,TcrbCl1)1Shrm/J
002761   B10.Cg-Tg(TcrAND)53Hed/J
003147   B10.D2-Hc1 H2d H2-T18c/nSnJ-Tg(DO11.10)10Dlo/J
003200   B10.PL-H2u H2-T18a/(73NS)Sn-Tg(TCRB)C14Jg/J
002122   B6.129P2-Tcrbtm1Mom Tcrdtm1Mom/J
002118   B6.129P2-Tcrbtm1Mom/J
008684   B6.Cg-Rag1tm1Mom Tyrp1B-w Tg(Tcra,Tcrb)9Rest/J
014550   B6.Cg-Thy1a Tg(TcraCWM5,TcrbCWM5)1807Wuth/J
005023   B6.Cg-Thy1a/Cy Tg(TcraTcrb)8Rest/J
005655   B6.Cg-Tg(Tcra,Tcrb)3Ayr/J
008428   B6.Cg-Tg(Tcra,Tcrb)HRCAll/J
008429   B6.Cg-Tg(Tcra,Tcrb)HRVAll/J
008006   B6.Cg-Tg(Tcra51-11.5,Tcrb51-11.5)AR206Ayr/J
005236   B6.Cg-Tg(TcraY1,TcrbY1)416Tev/J
008430   B6.Cg-Tg(Tcrb)HRBAll/J
004555   B6.NOD-(D17Mit21-D17Mit10) Tg(TCRbAI4)1Dvs/DvsJ
002121   B6;129P-Tcrbtm1Mom Tcrdtm1Mom/J
002117   B6;129P2-Tcrbtm1Mom/J
004694   B6;D2-Tg(TcrLCMV)327Sdz/JDvsJ
002408   B6;SJL-Tg(TcrAND)53Hed/J
021880   BXSB.B6-Tg(TcraTcrb)1100Mjb/DcrJ
004364   C.Cg-Tcratm1Mom Tcrbtm1Mom/J
003303   C.Cg-Tg(DO11.10)10Dlo/J
002047   C.SJL-Tcrba Tcrac/SlkJ
002046   C.SJL-Tcrba/SlkJ
011005   C57BL/6-Tg(H2-Kb-Tcra,-Tcrb)P25Ktk/J
026970   C57BL/6-Tg(Tcra,Tcrb)1Litt/J
006912   C57BL/6-Tg(Tcra2D2,Tcrb2D2)1Kuch/J
003831   C57BL/6-Tg(TcraTcrb)1100Mjb/J
027230   C57BL/6J-Tg(Tcra,Tcrb)2Litt/J
003540   C57L/J-Tg(Tcrb)93Vbo/J
005307   CBy.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005922   CBy.Cg-Thy1a Tg(TcraCl1,TcrbCl1)1Shrm/J
007081   CByJ.129P2(B6)-Tcrbtm1Mom/J
005694   D1Lac.Cg-Tg(Tcra,Tcrb)24Efro/J
017314   NOD-Tg(TcraTcrb)2H6Lwn/J
023082   NOD.129P2(Cg)-Tcrbtm1Mom/MnkaJ
006437   NOD.Cg-(Gpi1-D7Mit346)C57BL/6J Tg(TcrbAI4)1Dvs/DvsJ
026243   NOD.Cg-(D9rs4135590-D9rs13480186)H2k2Tg(ILK3mHEL)3Ccg Tg(TcrHEL3A9)1Mmd/SlsgJ
026624   NOD.Cg-(D9rs6385855-D9rs13480186)H2k2Tg(ILK3mHEL)3Ccg Tg(TcrHEL3A9)1Mmd/SlsgJ
004257   NOD.Cg-Prkdcscid Tg(TcrLCMV)327Sdz/DvsJ
009377   NOD.Cg-Rag1tm1Mom Tg(TcraBDC12-4.1)10Jos Tg(TcrbBDC12-4.1)82Gse/J
024476   NOD.Cg-Stat4tm1Gru Thy1a Ifngr1tm1Agt Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/LmbrJ
005686   NOD.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
004696   NOD.Cg-Tg(TcrLCMV)327Sdz/DvsJ
004460   NOD.Cg-Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/DoiJ
010526   NOD.Cg-Tg(TcraTcrbNY4.1)1Pesa/DvsJ
005868   NOD.Cg-Tg(TcraTcrbNY8.3)1Pesa/DvsJ
006304   NOD.FVB-Tg(TcrbBDC12-4.1)82Gse/GseJ
004335   NOD/ShiLt-Tg(TcrbAI4)1Dvs
018030   SJL.Cg-Tg(TcraTcrbVP2)1Bkim/J
002597   STOCK Tg(TcrHEL3A9)1Mmd/J
View Strains carrying other alleles of Tcrb     (53 strains)


Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype


        involves: C57BL/6
  • immune system phenotype
  • abnormal cytokine level
    • CD4 T cells cultured with OVA peptide-loaded spleen cells from B7 (CD80/86) deficient mice then restimulated with anti-CD3 produce lower amounts of IL-4, Il-17a, and interferon gamma (Ifng) than wild-type T cells   (MGI Ref ID J:112600)
  • homeostasis/metabolism phenotype
  • abnormal cytokine level
    • CD4 T cells cultured with OVA peptide-loaded spleen cells from B7 (CD80/86) deficient mice then restimulated with anti-CD3 produce lower amounts of IL-4, Il-17a, and interferon gamma (Ifng) than wild-type T cells   (MGI Ref ID J:112600)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.


        involves: BALB/c * C57BL/6
  • immune system phenotype
  • abnormal positive T cell selection
    • positive selection of CD4+ T cells is significantly greater in the thymus and lymph nodes compared to non-transgenic contro   (MGI Ref ID J:87876)
  • increased CD4-positive, alpha beta T cell number
    • cells from thymus and lymph nodes exhibit a fourfold increase in CD4 to CD8 peripheral T cell ratios as compared to non-transgenic control   (MGI Ref ID J:87876)
  • hematopoietic system phenotype
  • abnormal positive T cell selection
    • positive selection of CD4+ T cells is significantly greater in the thymus and lymph nodes compared to non-transgenic contro   (MGI Ref ID J:87876)
  • increased CD4-positive, alpha beta T cell number
    • cells from thymus and lymph nodes exhibit a fourfold increase in CD4 to CD8 peripheral T cell ratios as compared to non-transgenic control   (MGI Ref ID J:87876)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Developmental Biology Research
Lymphoid Tissue Defects

Immunology, Inflammation and Autoimmunity Research
Lymphoid Tissue Defects
      Lymphocyte Homing
      hematopoietic development
Rearranged Antigen-Specific T Cell Receptor Transgenes
      class II restricted
Vaccine Development

Research Tools
Immunology, Inflammation and Autoimmunity Research
      T Cell Receptor Transgenics

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol Tg(TcraTcrb)425Cbn
Allele Name transgene insertion 425, Frank Carbone
Allele Type Transgenic (Inserted expressed sequence)
Common Name(s) OT-2; OT-II; OT-II alphabeta TCR; OT-II.2; OT2; OTII; OTII TCR; TCR-OT-II.2a; TCRTg; Tg(TcraTcrb)425-2Cbn; TgN(OT-II.2a); TgN(TcrOT-II);
Mutation Made By Eric Butz,   Immunex Corp.
Strain of OriginC57BL/6 x B6.C-H2
Expressed Gene Tcra, T cell receptor alpha chain, mouse, laboratory
Expressed Gene Tcrb, T cell receptor beta chain, mouse, laboratory
Promoter Tcra, T cell receptor alpha chain, mouse, laboratory
Promoter Tcrb, T cell receptor beta chain, mouse, laboratory
General Note Transgenic mice express the mouse alpha-chain and beta-chain T-cell receptor that pairs with the CD4 coreceptor and is specific for chicken ovalbumin 323-339 in the context of I-A b. Homozygous transgenic mice are viable and fertile. In these mice there is a four-fold increase in the CD4 to CD8 peripheral T-cell ratio, and lymph node T-cells demonstrate a dose-dependent proliferative response to the specific ovalbumin ligand. Phenotypes for the two sublines (OT-II.2)425-2 and 426-6 are described as identical. (J:87876)
Molecular Note The transgene was generated by co-injection of two constructs created by separate cloning into a T-cell receptor expression vector the PCR-amplified cDNAs encoding mouse alpha-chain and beta-chain T-cell receptor subunits expressed by a CD4+ T-cell hybridoma designated Clone 1.1. The reconstituted receptor pairs with the CD4 coreceptor and is specific for chicken ovalbumin residues 323-339 in the context of H2-Ab1 (I-Ab). [MGI Ref ID J:87876]


Genotyping Information

Genotyping Protocols

Tg(Tcra)425Cbn QPCR, QPCR
Tg(Tcra)425Cbn STD PCR, Melt Curve Analysis
Tg(Tcra)425Cbn STD PCR, Standard PCR
Tg(Tcrb)425Cbn QPCR, QPCR
Tg(Tcrb)425Cbn STD PCR, Melt Curve Analysis
Tg(Tcrb)425Cbn STD PCR, Standard PCR

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Selected Reference(s)

Barnden MJ; Allison J; Heath WR; Carbone FR. 1998. Defective TCR expression in transgenic mice constructed using cDNA-based alpha- and beta-chain genes under the control of heterologous regulatory elements. Immunol Cell Biol 76(1):34-40. [PubMed: 9553774]  [MGI Ref ID J:87876]

Additional References

Parameswaran N; Samuvel DJ; Kumar R; Thatai S; Bal V; Rath S; George A. 2004. Oral tolerance in T cells is accompanied by induction of effector function in lymphoid organs after systemic immunization. Infect Immun 72(7):3803-11. [PubMed: 15213121]  [MGI Ref ID J:90986]

Tg(TcraTcrb)425Cbn related

Abboud G; Staumont-Salle D; Kanda A; Roumier T; Deruytter N; Lavogiez C; Fleury S; Remy P; Papin JP; Capron M; Dombrowicz D. 2009. Fc(epsilon)RI and FcgammaRIII/CD16 differentially regulate atopic dermatitis in mice. J Immunol 182(10):6517-26. [PubMed: 19414806]  [MGI Ref ID J:148317]

Abe BT; Shin DS; Mocholi E; Macian F. 2012. NFAT1 supports tumor-induced anergy of CD4(+) T cells. Cancer Res 72(18):4642-51. [PubMed: 22865456]  [MGI Ref ID J:191294]

Abou Fakher FH; Rachinel N; Klimczak M; Louis J; Doyen N. 2009. TLR9-dependent activation of dendritic cells by DNA from Leishmania major favors Th1 cell development and the resolution of lesions. J Immunol 182(3):1386-96. [PubMed: 19155485]  [MGI Ref ID J:144330]

Adoro S; Erman B; Sarafova SD; Van Laethem F; Park JH; Feigenbaum L; Singer A. 2008. Targeting CD4 coreceptor expression to postselection thymocytes reveals that CD4/CD8 lineage choice is neither error-prone nor stochastic. J Immunol 181(10):6975-83. [PubMed: 18981117]  [MGI Ref ID J:140942]

Adriani M; Jones KA; Uchiyama T; Kirby MR; Silvin C; Anderson SM; Candotti F. 2011. Defective inhibition of B-cell proliferation by Wiskott-Aldrich syndrome protein-deficient regulatory T cells. Blood 117(24):6608-11. [PubMed: 21515824]  [MGI Ref ID J:174827]

Afkarian M; Sedy JR; Yang J; Jacobson NG; Cereb N; Yang SY; Murphy TL; Murphy KM. 2002. T-bet is a STAT1-induced regulator of IL-12R expression in naive CD4+ T cells. Nat Immunol 3(6):549-57. [PubMed: 12006974]  [MGI Ref ID J:109160]

Agarwal RK; Horai R; Viley AM; Silver PB; Grajewski RS; Su SB; Yazdani AT; Zhu W; Kronenberg M; Murray PJ; Rutschman RL; Chan CC; Caspi RR. 2008. Abrogation of anti-retinal autoimmunity in IL-10 transgenic mice due to reduced T cell priming and inhibition of disease effector mechanisms. J Immunol 180(8):5423-9. [PubMed: 18390724]  [MGI Ref ID J:134256]

Ahmed KA; Wang L; Munegowda MA; Mulligan S; Gordon JR; Griebel P; Xiang J. 2012. Direct in vivo evidence of CD4+ T cell requirement for CTL response and memory via pMHC-I targeting and CD40L signaling. J Leukoc Biol 92(2):289-300. [PubMed: 22544940]  [MGI Ref ID J:186191]

Akbari M; Honma K; Kimura D; Miyakoda M; Kimura K; Matsuyama T; Yui K. 2014. IRF4 in dendritic cells inhibits IL-12 production and controls Th1 immune responses against Leishmania major. J Immunol 192(5):2271-9. [PubMed: 24489086]  [MGI Ref ID J:209798]

Akirav EM; Henegariu O; Preston-Hurlburt P; Schmidt AM; Clynes R; Herold KC. 2014. The receptor for advanced glycation end products (RAGE) affects T cell differentiation in OVA induced asthma. PLoS One 9(4):e95678. [PubMed: 24759895]  [MGI Ref ID J:215167]

Alari-Pahissa E; Notario L; Lorente E; Vega-Ramos J; Justel A; Lopez D; Villadangos JA; Lauzurica P. 2012. CD69 does not affect the extent of T cell priming. PLoS One 7(10):e48593. [PubMed: 23119065]  [MGI Ref ID J:192275]

Albrecht I; Niesner U; Janke M; Menning A; Loddenkemper C; Kuhl AA; Lepenies I; Lexberg MH; Westendorf K; Hradilkova K; Grun J; Hamann A; Epstein JA; Chang HD; Tokoyoda K; Radbruch A. 2010. Persistence of effector memory Th1 cells is regulated by Hopx. Eur J Immunol 40(11):2993-3006. [PubMed: 21061432]  [MGI Ref ID J:167626]

Albu DI; Feng D; Bhattacharya D; Jenkins NA; Copeland NG; Liu P; Avram D. 2007. BCL11B is required for positive selection and survival of double-positive thymocytes. J Exp Med 204(12):3003-15. [PubMed: 17998389]  [MGI Ref ID J:128515]

Aleyas AG; George JA; Han YW; Rahman MM; Kim SJ; Han SB; Kim BS; Kim K; Eo SK. 2009. Functional modulation of dendritic cells and macrophages by japanese encephalitis virus through MyD88 adaptor molecule-dependent and -independent pathways. J Immunol 183(4):2462-74. [PubMed: 19635909]  [MGI Ref ID J:151478]

Ali K; Soond DR; Pineiro R; Hagemann T; Pearce W; Lim EL; Bouabe H; Scudamore CL; Hancox T; Maecker H; Friedman L; Turner M; Okkenhaug K; Vanhaesebroeck B. 2014. Inactivation of PI(3)K p110delta breaks regulatory T-cell-mediated immune tolerance to cancer. Nature 510(7505):407-11. [PubMed: 24919154]  [MGI Ref ID J:213482]

Allen CD; Okada T; Tang HL; Cyster JG. 2007. Imaging of germinal center selection events during affinity maturation. Science 315(5811):528-31. [PubMed: 17185562]  [MGI Ref ID J:118931]

Amante FH; Haque A; Stanley AC; Rivera Fde L; Randall LM; Wilson YA; Yeo G; Pieper C; Crabb BS; de Koning-Ward TF; Lundie RJ; Good MF; Pinzon-Charry A; Pearson MS; Duke MG; McManus DP; Loukas A; Hill GR; Engwerda CR. 2010. Immune-Mediated Mechanisms of Parasite Tissue Sequestration during Experimental Cerebral Malaria. J Immunol 185(6):3632-42. [PubMed: 20720206]  [MGI Ref ID J:163540]

Anderson MS; Venanzi ES; Chen Z; Berzins SP; Benoist C; Mathis D. 2005. The cellular mechanism of Aire control of T cell tolerance. Immunity 23(2):227-39. [PubMed: 16111640]  [MGI Ref ID J:100515]

Angeli V; Ginhoux F; Llodra J; Quemeneur L; Frenette PS; Skobe M; Jessberger R; Merad M; Randolph GJ. 2006. B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization. Immunity 24(2):203-15. [PubMed: 16473832]  [MGI Ref ID J:113320]

Angiari S; Rossi B; Piccio L; Zinselmeyer BH; Budui S; Zenaro E; Della Bianca V; Bach SD; Scarpini E; Bolomini-Vittori M; Piacentino G; Dusi S; Laudanna C; Cross AH; Miller MJ; Constantin G. 2013. Regulatory T cells suppress the late phase of the immune response in lymph nodes through P-selectin glycoprotein ligand-1. J Immunol 191(11):5489-500. [PubMed: 24174617]  [MGI Ref ID J:207010]

Arias DA; McCarty N; Lu L; Maldonado RA; Shinohara ML; Cantor H. 2010. Unexpected role of clathrin adaptor AP-1 in MHC-dependent positive selection of T cells. Proc Natl Acad Sci U S A 107(6):2556-61. [PubMed: 20133794]  [MGI Ref ID J:157540]

Au-Yeung BB; Levin SE; Zhang C; Hsu LY; Cheng DA; Killeen N; Shokat KM; Weiss A. 2010. A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity. Nat Immunol 11(12):1085-92. [PubMed: 21037577]  [MGI Ref ID J:167326]

Au-Yeung BB; Zikherman J; Mueller JL; Ashouri JF; Matloubian M; Cheng DA; Chen Y; Shokat KM; Weiss A. 2014. A sharp T-cell antigen receptor signaling threshold for T-cell proliferation. Proc Natl Acad Sci U S A 111(35):E3679-88. [PubMed: 25136127]  [MGI Ref ID J:214817]

Backer R; van Leeuwen F; Kraal G; den Haan JM. 2008. CD8(-) dendritic cells preferentially cross-present Saccharomyces cerevisiae antigens. Eur J Immunol 38(2):370-80. [PubMed: 18200498]  [MGI Ref ID J:131361]

Baek KH; Shin HJ; Yoo JK; Cho JH; Choi YH; Sung YC; McKeon F; Lee CW. 2003. p53 deficiency and defective mitotic checkpoint in proliferating T lymphocytes increase chromosomal instability through aberrant exit from mitotic arrest. J Leukoc Biol 73(6):850-61. [PubMed: 12773518]  [MGI Ref ID J:121196]

Baine I; Basu S; Ames R; Sellers RS; Macian F. 2013. Helios induces epigenetic silencing of IL2 gene expression in regulatory T cells. J Immunol 190(3):1008-16. [PubMed: 23275607]  [MGI Ref ID J:193030]

Baker CM; Comrie WA; Hyun YM; Chung HL; Fedorchuk CA; Lim K; Brakebusch C; McGrath JL; Waugh RE; Meier-Schellersheim M; Kim M. 2012. Opposing roles for RhoH GTPase during T-cell migration and activation. Proc Natl Acad Sci U S A 109(26):10474-9. [PubMed: 22689994]  [MGI Ref ID J:185587]

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Zigmond E; Varol C; Farache J; Elmaliah E; Satpathy AT; Friedlander G; Mack M; Shpigel N; Boneca IG; Murphy KM; Shakhar G; Halpern Z; Jung S. 2012. Ly6C(hi) Monocytes in the Inflamed Colon Give Rise to Proinflammatory Effector Cells and Migratory Antigen-Presenting Cells. Immunity 37(6):1076-90. [PubMed: 23219392]  [MGI Ref ID J:191054]

Zikherman J; Jenne C; Watson S; Doan K; Raschke W; Goodnow CC; Weiss A. 2010. CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development. Immunity 32(3):342-54. [PubMed: 20346773]  [MGI Ref ID J:158876]

Zimmerli C; Lee BP; Palmer G; Gabay C; Adams R; Aurrand-Lions M; Imhof BA. 2009. Adaptive immune response in JAM-C-deficient mice: normal initiation but reduced IgG memory. J Immunol 182(8):4728-36. [PubMed: 19342649]  [MGI Ref ID J:147736]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX30

Colony Maintenance

Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Breeding Considerations This strain is a good breeder.
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Weeks of AgePrice per mouse (US dollars $)GenderGenotypes Provided
3 weeks $159.80Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
4 weeks $159.80Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
5 weeks $159.80Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
6 weeks $165.25Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
7 weeks $170.70Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
8 weeks $176.15Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
9 weeks $181.60Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
10 weeks $187.05Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
11 weeks $192.50Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
12 weeks $197.95Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
13 weeks $203.40Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
14 weeks $208.85Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
15 weeks $214.30Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  

Standard Supply

Level 3. Up to 50 mice. Larger quantities or custom orders arranged upon request.

Supply Notes

  • Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.


Frozen Products

Price (US dollars $)
Frozen Embryo $1725.00

Standard Supply

Level 3. Up to 50 mice. Larger quantities or custom orders arranged upon request.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Weeks of AgePrice per mouse (US dollars $)GenderGenotypes Provided
3 weeks $207.80Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
4 weeks $207.80Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
5 weeks $207.80Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
6 weeks $214.90Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
7 weeks $222.00Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
8 weeks $229.00Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
9 weeks $236.10Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
10 weeks $243.20Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
11 weeks $250.30Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
12 weeks $257.40Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
13 weeks $264.50Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
14 weeks $271.60Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
15 weeks $278.60Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  

Standard Supply

Level 3. Up to 50 mice. Larger quantities or custom orders arranged upon request.

Supply Notes

  • Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.


Frozen Products

Price (US dollars $)
Frozen Embryo $2242.50

Standard Supply

Level 3. Up to 50 mice. Larger quantities or custom orders arranged upon request.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Level 3. Up to 50 mice. Larger quantities or custom orders arranged upon request.

Control Information

   000664 C57BL/6J
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use

General Terms and Conditions

Contact information

General inquiries regarding Terms of Use

Contracts Administration


JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty


In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.