Strain Name:

B6.Cg-Tg(TcraTcrb)425Cbn/J

Stock Number:

004194

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Availability:

Level 3

These transgenic mice express the mouse alpha-chain and beta-chain T cell receptor that pairs with the CD4 coreceptor and is specific for chicken ovalbumin 323-339 in the context of I-A b. In these mice there is a four-fold increase in the CD4 to CD8 peripheral T cell ratio, and lymph node T cells demonstrate a dose-dependent proliferative response to the specific ovalbumin ligand. These transgenic mice are useful for studying in vivo T cell biology such as TCR-ligand interactions, T cell activation, thymic selection, cross-presentation of antigens, process of thymic selection and central and peripheral T cell tolerance and induction.

Description

Strain Information

Former Names C57BL/6-Tg(TcraTcrb)425Cbn/J    (Changed: 09-APR-10 )
Type Congenic; Mutant Strain; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Breeding Considerations This strain is a good breeder.
Specieslaboratory mouse
H2 Haplotypeb
GenerationN4F?N3F10pF3 (14-AUG-14)
Generation Definitions
 
Donating Investigator Frank Carbone,   University of Melbourne

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Description
These transgenic mice express the mouse alpha-chain and beta-chain T cell receptor that pairs with the CD4 coreceptor and is specific for chicken ovalbumin 323-339 in the context of I-A b. Homozygous mice are viable and fertile. In these mice there is a four-fold increase in the CD4 to CD8 peripheral T cell ratio, and lymph node T cells demonstrate a dose-dependent proliferative response to the specific ovalbumin ligand. These transgenic mice are useful for studying in vivo T cell biology such as TCR-ligand interactions, T cell activation, thymic selection, cross-presentation of antigens, process of thymic selection and central and peripheral T cell tolerance and induction.

Development
Transgenic constructs containing the alpha-chain and beta-chain of the T-cell receptor from a T cell hybridoma clone including the endogenous TCR promoter were coinjected into fertilized B6 x B6.C-H2bm1 mouse eggs. The T cell hybridoma clone is CD4+, MHC class II-restricted and is specific for the ovalbumin residue 323-339 peptides in the context of the MHC class II I-A2 molecule. Founder animals (described as OT-II.2 subline 425-2) were bred to wild-type B6 mice.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

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005308   B10.Cg-H2d Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005895   B10.Cg-Thy1a H2d Tg(TcraCl1,TcrbCl1)1Shrm/J
002761   B10.Cg-Tg(TcrAND)53Hed/J
003147   B10.D2-Hc1 H2d H2-T18c/nSnJ-Tg(DO11.10)10Dlo/J
003199   B10.PL-H2u H2-T18a/(73NS)Sn-Tg(TCRA)B1Jg/J
002116   B6.129S2-Tcratm1Mom/J
022073   B6.Cg-Rag1tm1Mom Thy1a Tg(Tcra2C,Tcrb2C)1Dlo/J
008684   B6.Cg-Rag1tm1Mom Tyrp1B-w Tg(Tcra,Tcrb)9Rest/J
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005655   B6.Cg-Tg(Tcra,Tcrb)3Ayr/J
008428   B6.Cg-Tg(Tcra,Tcrb)HRCAll/J
008429   B6.Cg-Tg(Tcra,Tcrb)HRVAll/J
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005236   B6.Cg-Tg(TcraY1,TcrbY1)416Tev/J
004554   B6.NOD-(D17Mit21-D17Mit10) Tg(TCRaAI4)1Dvs/DvsJ
002115   B6;129S2-Tcratm1Mom/J
004694   B6;D2-Tg(TcrLCMV)327Sdz/JDvsJ
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004364   C.Cg-Tcratm1Mom Tcrbtm1Mom/J
003303   C.Cg-Tg(DO11.10)10Dlo/J
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014639   C57BL/6-Tg(Cd4-TcraDN32D3)1Aben/J
011005   C57BL/6-Tg(H2-Kb-Tcra,-Tcrb)P25Ktk/J
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005922   CBy.Cg-Thy1a Tg(TcraCl1,TcrbCl1)1Shrm/J
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006436   NOD.Cg-(Gpi1-D7Mit346)C57BL/6J Tg(TcraAI4)1Dvs/DvsJ
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004460   NOD.Cg-Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/DoiJ
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005868   NOD.Cg-Tg(TcraTcrbNY8.3)1Pesa/DvsJ
006303   NOD.FVB-Tg(TcraBDC12-4.1)10Jos/GseJ
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View Strains carrying other alleles of Tcra     (48 strains)

Strains carrying other alleles of Tcrb
005308   B10.Cg-H2d Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005895   B10.Cg-Thy1a H2d Tg(TcraCl1,TcrbCl1)1Shrm/J
002761   B10.Cg-Tg(TcrAND)53Hed/J
003147   B10.D2-Hc1 H2d H2-T18c/nSnJ-Tg(DO11.10)10Dlo/J
003200   B10.PL-H2u H2-T18a/(73NS)Sn-Tg(TCRB)C14Jg/J
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002118   B6.129P2-Tcrbtm1Mom/J
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002121   B6;129P-Tcrbtm1Mom Tcrdtm1Mom/J
002117   B6;129P2-Tcrbtm1Mom/J
004694   B6;D2-Tg(TcrLCMV)327Sdz/JDvsJ
002408   B6;SJL-Tg(TcrAND)53Hed/J
021880   BXSB.B6-Tg(TcraTcrb)1100Mjb/DcrJ
004364   C.Cg-Tcratm1Mom Tcrbtm1Mom/J
003303   C.Cg-Tg(DO11.10)10Dlo/J
002047   C.SJL-Tcrba Tcrac/SlkJ
002046   C.SJL-Tcrba/SlkJ
011005   C57BL/6-Tg(H2-Kb-Tcra,-Tcrb)P25Ktk/J
006912   C57BL/6-Tg(Tcra2D2,Tcrb2D2)1Kuch/J
003831   C57BL/6-Tg(TcraTcrb)1100Mjb/J
003540   C57L/J-Tg(Tcrb)93Vbo/J
005307   CBy.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005922   CBy.Cg-Thy1a Tg(TcraCl1,TcrbCl1)1Shrm/J
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024476   NOD.Cg-Stat4tm1Gru Thy1a Ifngr1tm1Agt Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/LmbrJ
005686   NOD.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
004696   NOD.Cg-Tg(TcrLCMV)327Sdz/DvsJ
004460   NOD.Cg-Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/DoiJ
010526   NOD.Cg-Tg(TcraTcrbNY4.1)1Pesa/DvsJ
005868   NOD.Cg-Tg(TcraTcrbNY8.3)1Pesa/DvsJ
006304   NOD.FVB-Tg(TcrbBDC12-4.1)82Gse/GseJ
004335   NOD/ShiLt-Tg(TcrbAI4)1Dvs
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View Strains carrying other alleles of Tcrb     (50 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Tg(TcraTcrb)425Cbn/0

        involves: C57BL/6
  • immune system phenotype
  • abnormal cytokine level
    • CD4 T cells cultured with OVA peptide-loaded spleen cells from B7 (CD80/86) deficient mice then restimulated with anti-CD3 produce lower amounts of IL-4, Il-17a, and interferon gamma (Ifng) than wild-type T cells   (MGI Ref ID J:112600)
  • homeostasis/metabolism phenotype
  • abnormal cytokine level
    • CD4 T cells cultured with OVA peptide-loaded spleen cells from B7 (CD80/86) deficient mice then restimulated with anti-CD3 produce lower amounts of IL-4, Il-17a, and interferon gamma (Ifng) than wild-type T cells   (MGI Ref ID J:112600)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Tg(TcraTcrb)425Cbn/?

        involves: BALB/c * C57BL/6
  • immune system phenotype
  • abnormal positive T cell selection
    • positive selection of CD4+ T cells is significantly greater in the thymus and lymph nodes compared to non-transgenic contro   (MGI Ref ID J:87876)
  • increased CD4-positive, alpha beta T cell number
    • cells from thymus and lymph nodes exhibit a fourfold increase in CD4 to CD8 peripheral T cell ratios as compared to non-transgenic control   (MGI Ref ID J:87876)
  • hematopoietic system phenotype
  • abnormal positive T cell selection
    • positive selection of CD4+ T cells is significantly greater in the thymus and lymph nodes compared to non-transgenic contro   (MGI Ref ID J:87876)
  • increased CD4-positive, alpha beta T cell number
    • cells from thymus and lymph nodes exhibit a fourfold increase in CD4 to CD8 peripheral T cell ratios as compared to non-transgenic control   (MGI Ref ID J:87876)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Developmental Biology Research
Lymphoid Tissue Defects

Immunology, Inflammation and Autoimmunity Research
Lymphoid Tissue Defects
      Lymphocyte Homing
      hematopoietic development
Rearranged Antigen-Specific T Cell Receptor Transgenes
      class II restricted
Vaccine Development

Research Tools
Immunology, Inflammation and Autoimmunity Research
      T Cell Receptor Transgenics

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Tg(TcraTcrb)425Cbn
Allele Name transgene insertion 425, Frank Carbone
Allele Type Transgenic (Inserted expressed sequence)
Common Name(s) OT-2; OT-II; OT-II alphabeta TCR; OT-II.2; OT2; OTII; OTII TCR; TCR-OT-II.2a; TCRTg; Tg(TcraTcrb)425-2Cbn; TgN(OT-II.2a); TgN(TcrOT-II);
Mutation Made By Eric Butz,   Immunex Corp.
Strain of OriginC57BL/6 x B6.C-H2
Expressed Gene Tcra, T cell receptor alpha chain, mouse, laboratory
Expressed Gene Tcrb, T cell receptor beta chain, mouse, laboratory
Promoter Tcra, T cell receptor alpha chain, mouse, laboratory
Promoter Tcrb, T cell receptor beta chain, mouse, laboratory
General Note Transgenic mice express the mouse alpha-chain and beta-chain T-cell receptor that pairs with the CD4 coreceptor and is specific for chicken ovalbumin 323-339 in the context of I-A b. Homozygous transgenic mice are viable and fertile. In these mice there is a four-fold increase in the CD4 to CD8 peripheral T-cell ratio, and lymph node T-cells demonstrate a dose-dependent proliferative response to the specific ovalbumin ligand. Phenotypes for the two sublines (OT-II.2)425-2 and 426-6 are described as identical. (J:87876)
Molecular Note The transgene was generated by co-injection of two constructs created by separate cloning into a T-cell receptor expression vector the PCR-amplified cDNAs encoding mouse alpha-chain and beta-chain T-cell receptor subunits expressed by a CD4+ T-cell hybridoma designated Clone 1.1. The reconstituted receptor pairs with the CD4 coreceptor and is specific for chicken ovalbumin residues 323-339 in the context of H2-Ab1 (I-Ab). [MGI Ref ID J:87876]
 
 

Genotyping

Genotyping Information

Genotyping Protocols

Tg(Tcra)425Cbn QPCR, QPCR
Tg(Tcra)425Cbn STD PCR, Standard PCR
Tg(Tcrb)425Cbn QPCR, QPCR
Tg(Tcrb)425Cbn STD PCR, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Barnden MJ; Allison J; Heath WR; Carbone FR. 1998. Defective TCR expression in transgenic mice constructed using cDNA-based alpha- and beta-chain genes under the control of heterologous regulatory elements. Immunol Cell Biol 76(1):34-40. [PubMed: 9553774]  [MGI Ref ID J:87876]

Additional References

Parameswaran N; Samuvel DJ; Kumar R; Thatai S; Bal V; Rath S; George A. 2004. Oral tolerance in T cells is accompanied by induction of effector function in lymphoid organs after systemic immunization. Infect Immun 72(7):3803-11. [PubMed: 15213121]  [MGI Ref ID J:90986]

Tg(TcraTcrb)425Cbn related

Abboud G; Staumont-Salle D; Kanda A; Roumier T; Deruytter N; Lavogiez C; Fleury S; Remy P; Papin JP; Capron M; Dombrowicz D. 2009. Fc(epsilon)RI and FcgammaRIII/CD16 differentially regulate atopic dermatitis in mice. J Immunol 182(10):6517-26. [PubMed: 19414806]  [MGI Ref ID J:148317]

Abe BT; Shin DS; Mocholi E; Macian F. 2012. NFAT1 supports tumor-induced anergy of CD4(+) T cells. Cancer Res 72(18):4642-51. [PubMed: 22865456]  [MGI Ref ID J:191294]

Abou Fakher FH; Rachinel N; Klimczak M; Louis J; Doyen N. 2009. TLR9-dependent activation of dendritic cells by DNA from Leishmania major favors Th1 cell development and the resolution of lesions. J Immunol 182(3):1386-96. [PubMed: 19155485]  [MGI Ref ID J:144330]

Adoro S; Erman B; Sarafova SD; Van Laethem F; Park JH; Feigenbaum L; Singer A. 2008. Targeting CD4 coreceptor expression to postselection thymocytes reveals that CD4/CD8 lineage choice is neither error-prone nor stochastic. J Immunol 181(10):6975-83. [PubMed: 18981117]  [MGI Ref ID J:140942]

Adriani M; Jones KA; Uchiyama T; Kirby MR; Silvin C; Anderson SM; Candotti F. 2011. Defective inhibition of B-cell proliferation by Wiskott-Aldrich syndrome protein-deficient regulatory T cells. Blood 117(24):6608-11. [PubMed: 21515824]  [MGI Ref ID J:174827]

Afkarian M; Sedy JR; Yang J; Jacobson NG; Cereb N; Yang SY; Murphy TL; Murphy KM. 2002. T-bet is a STAT1-induced regulator of IL-12R expression in naive CD4+ T cells. Nat Immunol 3(6):549-57. [PubMed: 12006974]  [MGI Ref ID J:109160]

Agarwal RK; Horai R; Viley AM; Silver PB; Grajewski RS; Su SB; Yazdani AT; Zhu W; Kronenberg M; Murray PJ; Rutschman RL; Chan CC; Caspi RR. 2008. Abrogation of anti-retinal autoimmunity in IL-10 transgenic mice due to reduced T cell priming and inhibition of disease effector mechanisms. J Immunol 180(8):5423-9. [PubMed: 18390724]  [MGI Ref ID J:134256]

Ahmed KA; Wang L; Munegowda MA; Mulligan S; Gordon JR; Griebel P; Xiang J. 2012. Direct in vivo evidence of CD4+ T cell requirement for CTL response and memory via pMHC-I targeting and CD40L signaling. J Leukoc Biol 92(2):289-300. [PubMed: 22544940]  [MGI Ref ID J:186191]

Akbari M; Honma K; Kimura D; Miyakoda M; Kimura K; Matsuyama T; Yui K. 2014. IRF4 in dendritic cells inhibits IL-12 production and controls Th1 immune responses against Leishmania major. J Immunol 192(5):2271-9. [PubMed: 24489086]  [MGI Ref ID J:209798]

Alari-Pahissa E; Notario L; Lorente E; Vega-Ramos J; Justel A; Lopez D; Villadangos JA; Lauzurica P. 2012. CD69 does not affect the extent of T cell priming. PLoS One 7(10):e48593. [PubMed: 23119065]  [MGI Ref ID J:192275]

Albrecht I; Niesner U; Janke M; Menning A; Loddenkemper C; Kuhl AA; Lepenies I; Lexberg MH; Westendorf K; Hradilkova K; Grun J; Hamann A; Epstein JA; Chang HD; Tokoyoda K; Radbruch A. 2010. Persistence of effector memory Th1 cells is regulated by Hopx. Eur J Immunol 40(11):2993-3006. [PubMed: 21061432]  [MGI Ref ID J:167626]

Albu DI; Feng D; Bhattacharya D; Jenkins NA; Copeland NG; Liu P; Avram D. 2007. BCL11B is required for positive selection and survival of double-positive thymocytes. J Exp Med 204(12):3003-15. [PubMed: 17998389]  [MGI Ref ID J:128515]

Aleyas AG; George JA; Han YW; Rahman MM; Kim SJ; Han SB; Kim BS; Kim K; Eo SK. 2009. Functional modulation of dendritic cells and macrophages by japanese encephalitis virus through MyD88 adaptor molecule-dependent and -independent pathways. J Immunol 183(4):2462-74. [PubMed: 19635909]  [MGI Ref ID J:151478]

Allen CD; Okada T; Tang HL; Cyster JG. 2007. Imaging of germinal center selection events during affinity maturation. Science 315(5811):528-31. [PubMed: 17185562]  [MGI Ref ID J:118931]

Amante FH; Haque A; Stanley AC; Rivera Fde L; Randall LM; Wilson YA; Yeo G; Pieper C; Crabb BS; de Koning-Ward TF; Lundie RJ; Good MF; Pinzon-Charry A; Pearson MS; Duke MG; McManus DP; Loukas A; Hill GR; Engwerda CR. 2010. Immune-Mediated Mechanisms of Parasite Tissue Sequestration during Experimental Cerebral Malaria. J Immunol 185(6):3632-42. [PubMed: 20720206]  [MGI Ref ID J:163540]

Anderson MS; Venanzi ES; Chen Z; Berzins SP; Benoist C; Mathis D. 2005. The cellular mechanism of Aire control of T cell tolerance. Immunity 23(2):227-39. [PubMed: 16111640]  [MGI Ref ID J:100515]

Angeli V; Ginhoux F; Llodra J; Quemeneur L; Frenette PS; Skobe M; Jessberger R; Merad M; Randolph GJ. 2006. B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization. Immunity 24(2):203-15. [PubMed: 16473832]  [MGI Ref ID J:113320]

Angiari S; Rossi B; Piccio L; Zinselmeyer BH; Budui S; Zenaro E; Della Bianca V; Bach SD; Scarpini E; Bolomini-Vittori M; Piacentino G; Dusi S; Laudanna C; Cross AH; Miller MJ; Constantin G. 2013. Regulatory T cells suppress the late phase of the immune response in lymph nodes through P-selectin glycoprotein ligand-1. J Immunol 191(11):5489-500. [PubMed: 24174617]  [MGI Ref ID J:207010]

Arias DA; McCarty N; Lu L; Maldonado RA; Shinohara ML; Cantor H. 2010. Unexpected role of clathrin adaptor AP-1 in MHC-dependent positive selection of T cells. Proc Natl Acad Sci U S A 107(6):2556-61. [PubMed: 20133794]  [MGI Ref ID J:157540]

Au-Yeung BB; Levin SE; Zhang C; Hsu LY; Cheng DA; Killeen N; Shokat KM; Weiss A. 2010. A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity. Nat Immunol 11(12):1085-92. [PubMed: 21037577]  [MGI Ref ID J:167326]

Backer R; van Leeuwen F; Kraal G; den Haan JM. 2008. CD8(-) dendritic cells preferentially cross-present Saccharomyces cerevisiae antigens. Eur J Immunol 38(2):370-80. [PubMed: 18200498]  [MGI Ref ID J:131361]

Baek KH; Shin HJ; Yoo JK; Cho JH; Choi YH; Sung YC; McKeon F; Lee CW. 2003. p53 deficiency and defective mitotic checkpoint in proliferating T lymphocytes increase chromosomal instability through aberrant exit from mitotic arrest. J Leukoc Biol 73(6):850-61. [PubMed: 12773518]  [MGI Ref ID J:121196]

Baine I; Basu S; Ames R; Sellers RS; Macian F. 2013. Helios induces epigenetic silencing of IL2 gene expression in regulatory T cells. J Immunol 190(3):1008-16. [PubMed: 23275607]  [MGI Ref ID J:193030]

Baker CM; Comrie WA; Hyun YM; Chung HL; Fedorchuk CA; Lim K; Brakebusch C; McGrath JL; Waugh RE; Meier-Schellersheim M; Kim M. 2012. Opposing roles for RhoH GTPase during T-cell migration and activation. Proc Natl Acad Sci U S A 109(26):10474-9. [PubMed: 22689994]  [MGI Ref ID J:185587]

Balasubramani A; Winstead CJ; Turner H; Janowski KM; Harbour SN; Shibata Y; Crawford GE; Hatton RD; Weaver CT. 2014. Deletion of a conserved cis-element in the Ifng locus highlights the role of acute histone acetylation in modulating inducible gene transcription. PLoS Genet 10(1):e1003969. [PubMed: 24415943]  [MGI Ref ID J:208819]

Balkow S; Heinz S; Schmidbauer P; Kolanus W; Holzmann B; Grabbe S; Laschinger M. 2010. LFA-1 activity state on dendritic cells regulates contact duration with T cells and promotes T-cell priming. Blood 116(11):1885-94. [PubMed: 20530790]  [MGI Ref ID J:164518]

Bandukwala HS; Clay BS; Tong J; Mody PD; Cannon JL; Shilling RA; Verbeek JS; Weinstock JV; Solway J; Sperling AI. 2007. Signaling through Fc gamma RIII is required for optimal T helper type (Th)2 responses and Th2-mediated airway inflammation. J Exp Med 204(8):1875-89. [PubMed: 17664287]  [MGI Ref ID J:125951]

Bandukwala HS; Gagnon J; Togher S; Greenbaum JA; Lamperti ED; Parr NJ; Molesworth AM; Smithers N; Lee K; Witherington J; Tough DF; Prinjha RK; Peters B; Rao A. 2012. Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors. Proc Natl Acad Sci U S A 109(36):14532-7. [PubMed: 22912406]  [MGI Ref ID J:189876]

Bandyopadhyay S; Valdor R; Macian F. 2014. Tle4 regulates epigenetic silencing of gamma interferon expression during effector T helper cell tolerance. Mol Cell Biol 34(2):233-45. [PubMed: 24190972]  [MGI Ref ID J:207682]

Barber DL; Mayer-Barber KD; Antonelli LR; Wilson MS; White S; Caspar P; Hieny S; Sereti I; Sher A. 2010. Th1-driven immune reconstitution disease in Mycobacterium avium-infected mice. Blood 116(18):3485-93. [PubMed: 20656932]  [MGI Ref ID J:166473]

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Yang CY; Vogt TK; Favre S; Scarpellino L; Huang HY; Tacchini-Cottier F; Luther SA. 2014. Trapping of naive lymphocytes triggers rapid growth and remodeling of the fibroblast network in reactive murine lymph nodes. Proc Natl Acad Sci U S A 111(1):E109-18. [PubMed: 24367096]  [MGI Ref ID J:206381]

Yang D; Postnikov YV; Li Y; Tewary P; de la Rosa G; Wei F; Klinman D; Gioannini T; Weiss JP; Furusawa T; Bustin M; Oppenheim JJ. 2012. High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses. J Exp Med 209(1):157-71. [PubMed: 22184635]  [MGI Ref ID J:181721]

Yang H; Lee SM; Gao B; Zhang J; Fang D. 2013. Histone deacetylase sirtuin 1 deacetylates IRF1 protein and programs dendritic cells to control Th17 protein differentiation during autoimmune inflammation. J Biol Chem 288(52):37256-66. [PubMed: 24214980]  [MGI Ref ID J:207189]

Yang K; Shrestha S; Zeng H; Karmaus PW; Neale G; Vogel P; Guertin DA; Lamb RF; Chi H. 2013. T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming. Immunity 39(6):1043-56. [PubMed: 24315998]  [MGI Ref ID J:209300]

Yang X; Zhang X; Fu ML; Weichselbaum RR; Gajewski TF; Guo Y; Fu YX. 2014. Targeting the tumor microenvironment with interferon-beta bridges innate and adaptive immune responses. Cancer Cell 25(1):37-48. [PubMed: 24434209]  [MGI Ref ID J:208155]

Yang XO; Nurieva R; Martinez GJ; Kang HS; Chung Y; Pappu BP; Shah B; Chang SH; Schluns KS; Watowich SS; Feng XH; Jetten AM; Dong C. 2008. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity 29(1):44-56. [PubMed: 18585065]  [MGI Ref ID J:137851]

Yang XP; Ghoreschi K; Steward-Tharp SM; Rodriguez-Canales J; Zhu J; Grainger JR; Hirahara K; Sun HW; Wei L; Vahedi G; Kanno Y; O'Shea JJ; Laurence A. 2011. Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5. Nat Immunol 12(3):247-54. [PubMed: 21278738]  [MGI Ref ID J:169304]

Yang YH; Song W; Deane JA; Kao W; Ooi JD; Ngo D; Kitching AR; Morand EF; Hickey MJ. 2013. Deficiency of Annexin A1 in CD4+ T Cells Exacerbates T Cell-Dependent Inflammation. J Immunol 190(3):997-1007. [PubMed: 23267026]  [MGI Ref ID J:192600]

Yang Z; Fuss IJ; Watanabe T; Asano N; Davey MP; Rosenbaum JT; Strober W; Kitani A. 2007. NOD2 transgenic mice exhibit enhanced MDP-mediated down-regulation of TLR2 responses and resistance to colitis induction. Gastroenterology 133(5):1510-21. [PubMed: 17915219]  [MGI Ref ID J:130116]

Yano M; Kuroda N; Han H; Meguro-Horike M; Nishikawa Y; Kiyonari H; Maemura K; Yanagawa Y; Obata K; Takahashi S; Ikawa T; Satoh R; Kawamoto H; Mouri Y; Matsumoto M. 2008. Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance. J Exp Med 205(12):2827-38. [PubMed: 19015306]  [MGI Ref ID J:141379]

Yao Y; Han W; Liang J; Ji J; Wang J; Cantor H; Lu L. 2013. Glatiramer acetate ameliorates inflammatory bowel disease in mice through the induction of Qa-1-restricted CD8(+) regulatory cells. Eur J Immunol 43(1):125-36. [PubMed: 23002042]  [MGI Ref ID J:191109]

Yau IW; Cato MH; Jellusova J; Hurtado de Mendoza T; Brink R; Rickert RC. 2013. Censoring of self-reactive B cells by follicular dendritic cell-displayed self-antigen. J Immunol 191(3):1082-90. [PubMed: 23817432]  [MGI Ref ID J:205710]

Ye Z; Ahmed KA; Huang J; Xie Y; Munegowda MA; Xiang J. 2008. T cell precursor frequency differentially affects CTL responses under different immune conditions. Biochem Biophys Res Commun 367(2):427-34. [PubMed: 18178159]  [MGI Ref ID J:131030]

Yi T; Wang X; Kelly LM; An J; Xu Y; Sailer AW; Gustafsson JA; Russell DW; Cyster JG. 2012. Oxysterol Gradient Generation by Lymphoid Stromal Cells Guides Activated B Cell Movement during Humoral Responses. Immunity 37(3):535-48. [PubMed: 22999953]  [MGI Ref ID J:188276]

Yin N; Xu J; Ginhoux F; Randolph GJ; Merad M; Ding Y; Bromberg JS. 2012. Functional specialization of islet dendritic cell subsets. J Immunol 188(10):4921-30. [PubMed: 22508930]  [MGI Ref ID J:188667]

Yin X; Ladi E; Chan SW; Li O; Killeen N; Kappes DJ; Robey EA. 2007. CCR7 expression in developing thymocytes is linked to the CD4 versus CD8 lineage decision. J Immunol 179(11):7358-64. [PubMed: 18025179]  [MGI Ref ID J:154818]

Yoshida M; Kobayashi K; Kuo TT; Bry L; Glickman JN; Claypool SM; Kaser A; Nagaishi T; Higgins DE; Mizoguchi E; Wakatsuki Y; Roopenian DC; Mizoguchi A; Lencer WI; Blumberg RS. 2006. Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria. J Clin Invest 116(8):2142-2151. [PubMed: 16841095]  [MGI Ref ID J:113122]

Yu D; Rao S; Tsai LM; Lee SK; He Y; Sutcliffe EL; Srivastava M; Linterman M; Zheng L; Simpson N; Ellyard JI; Parish IA; Ma CS; Li QJ; Parish CR; Mackay CR; Vinuesa CG. 2009. The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity 31(3):457-68. [PubMed: 19631565]  [MGI Ref ID J:152408]

Yu M; Li G; Lee WW; Yuan M; Cui D; Weyand CM; Goronzy JJ. 2012. Signal inhibition by the dual-specific phosphatase 4 impairs T cell-dependent B-cell responses with age. Proc Natl Acad Sci U S A 109(15):E879-88. [PubMed: 22434910]  [MGI Ref ID J:183484]

Yu Y; Iclozan C; Yamazaki T; Yang X; Anasetti C; Dong C; Yu XZ. 2009. Abundant c-Fas-associated death domain-like interleukin-1-converting enzyme inhibitory protein expression determines resistance of T helper 17 cells to activation-induced cell death. Blood 114(5):1026-8. [PubMed: 19429865]  [MGI Ref ID J:151173]

Yusuf I; Kageyama R; Monticelli L; Johnston RJ; Ditoro D; Hansen K; Barnett B; Crotty S. 2010. Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150). J Immunol 185(1):190-202. [PubMed: 20525889]  [MGI Ref ID J:161614]

Zakharova M; Ziegler HK. 2005. Paradoxical anti-inflammatory actions of TNF-alpha: inhibition of IL-12 and IL-23 via TNF receptor 1 in macrophages and dendritic cells. J Immunol 175(8):5024-33. [PubMed: 16210605]  [MGI Ref ID J:119097]

Zamisch M; Tian L; Grenningloh R; Xiong Y; Wildt KF; Ehlers M; Ho IC; Bosselut R. 2009. The transcription factor Ets1 is important for CD4 repression and Runx3 up-regulation during CD8 T cell differentiation in the thymus. J Exp Med 206(12):2685-99. [PubMed: 19917777]  [MGI Ref ID J:155097]

Zanoni I; Ostuni R; Barresi S; Di Gioia M; Broggi A; Costa B; Marzi R; Granucci F. 2012. CD14 and NFAT mediate lipopolysaccharide-induced skin edema formation in mice. J Clin Invest 122(5):1747-57. [PubMed: 22466648]  [MGI Ref ID J:184542]

Zanoni I; Ostuni R; Capuano G; Collini M; Caccia M; Ronchi AE; Rocchetti M; Mingozzi F; Foti M; Chirico G; Costa B; Zaza A; Ricciardi-Castagnoli P; Granucci F. 2009. CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation. Nature 460(7252):264-8. [PubMed: 19525933]  [MGI Ref ID J:150351]

Zehn D; Bevan MJ. 2006. T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity. Immunity 25(2):261-70. [PubMed: 16879996]  [MGI Ref ID J:113466]

Zehn D; Bevan MJ; Fink PJ. 2007. Cutting edge: TCR revision affects predominantly Foxp3 cells and skews them toward the Th17 lineage. J Immunol 179(9):5653-7. [PubMed: 17947636]  [MGI Ref ID J:153013]

Zelenay S; Keller AM; Whitney PG; Schraml BU; Deddouche S; Rogers NC; Schulz O; Sancho D; Reis e Sousa C. 2012. The dendritic cell receptor DNGR-1 controls endocytic handling of necrotic cell antigens to favor cross-priming of CTLs in virus-infected mice. J Clin Invest 122(5):1615-27. [PubMed: 22505458]  [MGI Ref ID J:184531]

Zhan Y; Purton JF; Godfrey DI; Cole TJ; Heath WR; Lew AM. 2003. Without peripheral interference, thymic deletion is mediated in a cohort of double-positive cells without classical activation. Proc Natl Acad Sci U S A 100(3):1197-202. [PubMed: 12538873]  [MGI Ref ID J:134984]

Zhan Y; Vega-Ramos J; Carrington EM; Villadangos JA; Lew AM; Xu Y. 2012. The inflammatory cytokine, GM-CSF, alters the developmental outcome of murine dendritic cells. Eur J Immunol 42(11):2889-900. [PubMed: 22806691]  [MGI Ref ID J:188716]

Zhang B; Kracker S; Yasuda T; Casola S; Vanneman M; Homig-Holzel C; Wang Z; Derudder E; Li S; Chakraborty T; Cotter SE; Koyama S; Currie T; Freeman GJ; Kutok JL; Rodig SJ; Dranoff G; Rajewsky K. 2012. Immune Surveillance and Therapy of Lymphomas Driven by Epstein-Barr Virus Protein LMP1 in a Mouse Model. Cell 148(4):739-51. [PubMed: 22341446]  [MGI Ref ID J:181546]

Zhang F; Thomas LR; Oltz EM; Aune TM. 2006. Control of thymocyte development and recombination-activating gene expression by the zinc finger protein Zfp608. Nat Immunol 7(12):1309-16. [PubMed: 17057722]  [MGI Ref ID J:116103]

Zhang J; Zahir N; Jiang Q; Miliotis H; Heyraud S; Meng X; Dong B; Xie G; Qiu F; Hao Z; McCulloch CA; Keystone EC; Peterson AC; Siminovitch KA. 2011. The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness. Nat Genet 43(9):902-7. [PubMed: 21841778]  [MGI Ref ID J:176519]

Zhang X; Munegowda MA; Yuan J; Wei Y; Xiang J. 2010. Optimal TLR9 signal converts tolerogenic CD4-8- DCs into immunogenic ones capable of stimulating antitumor immunity via activating CD4+ Th1/Th17 and NK cell responses. J Leukoc Biol 88(2):393-403. [PubMed: 20466823]  [MGI Ref ID J:163943]

Zhang Y; Chen YC; Krummel MF; Rosen SD. 2012. Autotaxin through lysophosphatidic acid stimulates polarization, motility, and transendothelial migration of naive T cells. J Immunol 189(8):3914-24. [PubMed: 22962684]  [MGI Ref ID J:190533]

Zhao H; Karman J; Jiang JL; Zhang J; Gumlaw N; Lydon J; Zhou Q; Qiu H; Jiang C; Cheng SH; Zhu Y. 2013. A Bispecific protein capable of engaging CTLA-4 and MHCII protects non-obese diabetic mice from autoimmune diabetes. PLoS One 8(5):e63530. [PubMed: 23704916]  [MGI Ref ID J:200723]

Zhao J; Zhao J; Fett C; Trandem K; Fleming E; Perlman S. 2011. IFN-gamma- and IL-10-expressing virus epitope-specific Foxp3(+) T reg cells in the central nervous system during encephalomyelitis. J Exp Med 208(8):1571-7. [PubMed: 21746812]  [MGI Ref ID J:177608]

Zheng L; Sharma R; Kung JT; Deshmukh US; Jarjour WN; Fu SM; Ju ST. 2008. Pervasive and stochastic changes in the TCR repertoire of regulatory T-cell-deficient mice. Int Immunol 20(4):517-23. [PubMed: 18310063]  [MGI Ref ID J:133521]

Zhong Y; Cantwell A; Dube PH. 2010. Transforming growth factor beta and CD25 are important for controlling systemic dissemination following Yersinia enterocolitica infection of the gut. Infect Immun 78(9):3716-25. [PubMed: 20584975]  [MGI Ref ID J:163014]

Zhou W; Dowell DR; Huckabee MM; Newcomb DC; Boswell MG; Goleniewska K; Lotz MT; Toki S; Yin H; Yao S; Natarajan C; Wu P; Sriram S; Breyer RM; Fitzgerald GA; Peebles RS Jr. 2012. Prostaglandin I2 signaling drives Th17 differentiation and exacerbates experimental autoimmune encephalomyelitis. PLoS One 7(5):e33518. [PubMed: 22590492]  [MGI Ref ID J:187249]

Zhu J; Liu X; Xie C; Yan M; Yu Y; Sobel ES; Wakeland EK; Mohan C. 2005. T cell hyperactivity in lupus as a consequence of hyperstimulatory antigen-presenting cells. J Clin Invest 115(7):1869-78. [PubMed: 15951839]  [MGI Ref ID J:99643]

Zietara N; Lyszkiewicz M; Gekara N; Puchalka J; Dos Santos VA; Hunt CR; Pandita TK; Lienenklaus S; Weiss S. 2009. Absence of IFN-beta impairs antigen presentation capacity of splenic dendritic cells via down-regulation of heat shock protein 70. J Immunol 183(2):1099-109. [PubMed: 19581626]  [MGI Ref ID J:151489]

Zigmond E; Varol C; Farache J; Elmaliah E; Satpathy AT; Friedlander G; Mack M; Shpigel N; Boneca IG; Murphy KM; Shakhar G; Halpern Z; Jung S. 2012. Ly6C(hi) Monocytes in the Inflamed Colon Give Rise to Proinflammatory Effector Cells and Migratory Antigen-Presenting Cells. Immunity 37(6):1076-90. [PubMed: 23219392]  [MGI Ref ID J:191054]

Zikherman J; Jenne C; Watson S; Doan K; Raschke W; Goodnow CC; Weiss A. 2010. CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development. Immunity 32(3):342-54. [PubMed: 20346773]  [MGI Ref ID J:158876]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX30

Colony Maintenance

Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Breeding Considerations This strain is a good breeder.
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Weeks of AgePrice per mouse (US dollars $)GenderGenotypes Provided
3 weeks $149.30Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
4 weeks $149.30Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
5 weeks $149.30Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
6 weeks $154.75Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
7 weeks $160.20Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
8 weeks $165.65Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
9 weeks $171.10Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
10 weeks $176.55Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
11 weeks $182.00Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
12 weeks $187.45Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
13 weeks $192.90Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
14 weeks $198.35Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
15 weeks $203.80Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
Price per Pair (US dollars $)Pair Genotype
$309.50Homozygous for Tg(TcraTcrb)425Cbn x Homozygous for Tg(TcraTcrb)425Cbn  

Standard Supply

Level 3. Up to 50 mice. Larger quantities or custom orders arranged upon request.

Supply Notes

  • Pair Pricing: Price may vary depending on the age of the males and females available for shipment. The price displayed is for a male and female at six weeks of age.
  • Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Weeks of AgePrice per mouse (US dollars $)GenderGenotypes Provided
3 weeks $194.10Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
4 weeks $194.10Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
5 weeks $194.10Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
6 weeks $201.20Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
7 weeks $208.30Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
8 weeks $215.40Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
9 weeks $222.50Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
10 weeks $229.60Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
11 weeks $236.60Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
12 weeks $243.70Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
13 weeks $250.80Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
14 weeks $257.90Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
15 weeks $265.00Female or MaleHomozygous for Tg(TcraTcrb)425Cbn  
Price per Pair (US dollars $)Pair Genotype
$402.40Homozygous for Tg(TcraTcrb)425Cbn x Homozygous for Tg(TcraTcrb)425Cbn  

Standard Supply

Level 3. Up to 50 mice. Larger quantities or custom orders arranged upon request.

Supply Notes

  • Pair Pricing: Price may vary depending on the age of the males and females available for shipment. The price displayed is for a male and female at six weeks of age.
  • Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Level 3. Up to 50 mice. Larger quantities or custom orders arranged upon request.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

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The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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