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- Description
- Phenotype
- Genes & alleles
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- Health & husbandry
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Description
Strain Information
Type Mutant Strain; Transgenic; Additional information on Genetically Engineered Mutant Mice. Mating System Homozygote x Homozygote (Female x Male) Species laboratory mouse Generation N4F?+15 (03-JAN-08) Donating Investigator Frank Carbone, University of Melbourne Description
These transgenic mice express the mouse alpha-chain and beta-chain T-cell receptor that pairs with the CD4 coreceptor and is specific for chicken ovalbumin 323-339 in the context of I-A b. Homozygous mice are viable and fertile. In these mice there is a four-fold increase in the CD4 to CD8 peripheral T-cell ratio, and lymph node T-cells demonstrate a dose-dependent proliferative response to the specific ovalbumin ligand. These transgenic mice are useful for studying in vivo T-cell biology such as TCR-ligand interactions, T-cell activation, thymic selection, cross-presentation of antigens, process of thymic selection and central and peripheral T-cell tolerance and induction.Development
Transgenic constructs containing the alpha-chain and beta-chain of the T-cell receptor from a T-cell hybridoma clone including the endogenous TCR promoter were coinjected into fertilized B6 x B6.C-H2bm1 mouse eggs. The T-cell hybridoma clone is CD4+, MHC class II-restricted and is specific for the ovalbumin residue 323-339 peptides in the context of the MHC class II I-A2 molecule. Founder animals (described as OT-II.2 subline 425-2) were bred to wildtype B6 mice.
Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of Tcra
View Strains carrying other alleles of Tcra (35 strains)
Additional Web Information
Genetic Quality Control Annual Report
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Tg(TcraTcrb)425Cbn/?
involves: BALB/c * C57BL/6
- immune system phenotype
- abnormal positive T cell selection (MGI Ref ID J:87876)
- positive selection of CD4+ T cells is significantly greater in the thymus and lymph nodes compared to non-transgenic contro
- increased CD4-positive T cell number (MGI Ref ID J:87876)
- cells from thymus and lymph nodes exhibit a fourfold increase in CD4 to CD8 peripheral T cell ratios as compared to non-transgenic control
- hematopoietic system phenotype
- abnormal positive T cell selection (MGI Ref ID J:87876)
- positive selection of CD4+ T cells is significantly greater in the thymus and lymph nodes compared to non-transgenic contro
- increased CD4-positive T cell number (MGI Ref ID J:87876)
- cells from thymus and lymph nodes exhibit a fourfold increase in CD4 to CD8 peripheral T cell ratios as compared to non-transgenic control
This mouse can be used to support research in many areas including:
Tcra relatedDevelopmental Biology Research
Lymphoid Tissue Defects
Immunology and Inflammation Research
Lymphoid Tissue Defects (Lymphocyte Homing)
Lymphoid Tissue Defects (hematopoietic development)
Rearranged Antigen-Specific T Cell Receptor Transgenes (class II restricted)
Vaccine Development
Research Tools
Immunology and Inflammation Research (T Cell Receptor Transgenics)
Tcrb relatedHematological Research
Immunological Defects
Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunodeficiency
Inflammation
T Cell Receptor Signaling Defects
Research Tools
Cancer Research (specific T cell deficiency)
Hematological Research
Immunological Defects
Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunodeficiency
Inflammation
T Cell Receptor Signaling Defects
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Tg(TcraTcrb)425Cbn | ||
|---|---|---|---|
| Allele Name | transgene insertion 425, Frank Carbone | ||
| Allele Type | Transgenic (random, expressed) | ||
| Common Name(s) | OT-2; OT-II; OT-II alphabeta TCR; OT-II.2; OT2; OTII; OTII TCR; TCR-OT-II.2a; TCRTg; TgN(OT-II.2a); TgN(TcrOT-II); | ||
| Mutation Made By | Eric Butz, Immunex Corp. | ||
| Strain of Origin | C57BL/6 x B6.C-H2 | ||
| Expressed Gene | Tcrb, T-cell receptor beta chain, mouse, laboratory | ||
| Expressed Gene | Tcra, T-cell receptor alpha chain, mouse, laboratory | ||
| General Note | Transgenic mice express the mouse alpha-chain and beta-chain T-cell receptor that pairs with the CD4 coreceptor and is specific for chicken ovalbumin 323-339 in the context of I-A b. Homozygous transgenic mice are viable and fertile. In these mice there is a four-fold increase in the CD4 to CD8 peripheral T-cell ratio, and lymph node T-cells demonstrate a dose-dependent proliferative response to the specific ovalbumin ligand. Phenotypes for the two sublines (OT-II.2)425-5 and 426-6 are described as identical. (J:87876) | ||
| Molecular Note | The transgene was generated by co-injection of two constructs created by separate cloning into a T-cell receptor expression vector the PCR-amplified cDNAs encoding mouse alpha-chain and beta-chain T-cell receptor subunits expressed by a CD4+ T-cell hybridoma designated Clone 1.1. The reconstituted receptor pairs with the CD4 coreceptor and is specific for chicken ovalbumin residues 323-339 in the context of H2-Ab1 (I-Ab). [MGI Ref ID J:87876] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Tg(Tcrb)425Cbn, QPCR, vers. 1
Tg(Tcrb)425Cbn, STD PCR, vers. 2
Helpful Links
Optimizing PCR Protocols
References
References
Selected Reference(s)
Barnden MJ; Allison J; Heath WR; Carbone FR. 1998. Defective TCR expression in transgenic mice constructed using cDNA-based alpha- and beta-chain genes under the control of heterologous regulatory elements. Immunol Cell Biol 76(1):34-40. [PubMed: 9553774] [MGI Ref ID J:87876]
Additional References
Parameswaran N; Samuvel DJ; Kumar R; Thatai S; Bal V; Rath S; George A. 2004. Oral tolerance in T cells is accompanied by induction of effector function in lymphoid organs after systemic immunization. Infect Immun 72(7):3803-11. [PubMed: 15213121] [MGI Ref ID J:90986]
Tg(TcraTcrb)425Cbn relatedAdoro S; Erman B; Sarafova SD; Van Laethem F; Park JH; Feigenbaum L; Singer A. 2008. Targeting CD4 coreceptor expression to postselection thymocytes reveals that CD4/CD8 lineage choice is neither error-prone nor stochastic. J Immunol 181(10):6975-83. [PubMed: 18981117] [MGI Ref ID J:140942]
Afkarian M; Sedy JR; Yang J; Jacobson NG; Cereb N; Yang SY; Murphy TL; Murphy KM. 2002. T-bet is a STAT1-induced regulator of IL-12R expression in naive CD4+ T cells. Nat Immunol 3(6):549-57. [PubMed: 12006974] [MGI Ref ID J:109160]
Agarwal RK; Horai R; Viley AM; Silver PB; Grajewski RS; Su SB; Yazdani AT; Zhu W; Kronenberg M; Murray PJ; Rutschman RL; Chan CC; Caspi RR. 2008. Abrogation of anti-retinal autoimmunity in IL-10 transgenic mice due to reduced T cell priming and inhibition of disease effector mechanisms. J Immunol 180(8):5423-9. [PubMed: 18390724] [MGI Ref ID J:134256]
Albu DI; Feng D; Bhattacharya D; Jenkins NA; Copeland NG; Liu P; Avram D. 2007. BCL11B is required for positive selection and survival of double-positive thymocytes. J Exp Med 204(12):3003-15. [PubMed: 17998389] [MGI Ref ID J:128515]
Allen CD; Okada T; Tang HL; Cyster JG. 2007. Imaging of germinal center selection events during affinity maturation. Science 315(5811):528-31. [PubMed: 17185562] [MGI Ref ID J:118931]
Anderson MS; Venanzi ES; Chen Z; Berzins SP; Benoist C; Mathis D. 2005. The cellular mechanism of Aire control of T cell tolerance. Immunity 23(2):227-39. [PubMed: 16111640] [MGI Ref ID J:100515]
Angeli V; Ginhoux F; Llodra J; Quemeneur L; Frenette PS; Skobe M; Jessberger R; Merad M; Randolph GJ. 2006. B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization. Immunity 24(2):203-15. [PubMed: 16473832] [MGI Ref ID J:113320]
Backer R; van Leeuwen F; Kraal G; den Haan JM. 2008. CD8(-) dendritic cells preferentially cross-present Saccharomyces cerevisiae antigens. Eur J Immunol 38(2):370-80. [PubMed: 18200498] [MGI Ref ID J:131361]
Baek KH; Shin HJ; Yoo JK; Cho JH; Choi YH; Sung YC; McKeon F; Lee CW. 2003. p53 deficiency and defective mitotic checkpoint in proliferating T lymphocytes increase chromosomal instability through aberrant exit from mitotic arrest. J Leukoc Biol 73(6):850-61. [PubMed: 12773518] [MGI Ref ID J:121196]
Bandukwala HS; Clay BS; Tong J; Mody PD; Cannon JL; Shilling RA; Verbeek JS; Weinstock JV; Solway J; Sperling AI. 2007. Signaling through Fc gamma RIII is required for optimal T helper type (Th)2 responses and Th2-mediated airway inflammation. J Exp Med 204(8):1875-89. [PubMed: 17664287] [MGI Ref ID J:125951]
Behrens GM; Li M; Davey GM; Allison J; Flavell RA; Carbone FR; Heath WR. 2004. Helper requirements for generation of effector CTL to islet beta cell antigens. J Immunol 172(9):5420-6. [PubMed: 15100283] [MGI Ref ID J:89639]
Beisner DR; Chu IH; Arechiga AF; Hedrick SM; Walsh CM. 2003. The requirements for Fas-associated death domain signaling in mature T cell activation and survival. J Immunol 171(1):247-56. [PubMed: 12817005] [MGI Ref ID J:132831]
Benedict CA; Loewendorf A; Garcia Z; Blazar BR; Janssen EM. 2008. Dendritic Cell Programming by Cytomegalovirus Stunts Naive T Cell Responses via the PD-L1/PD-1 Pathway. J Immunol 180(7):4836-47. [PubMed: 18354207] [MGI Ref ID J:133375]
Bettelli E; Baeten D; Jager A; Sobel RA; Kuchroo VK. 2006. Myelin oligodendrocyte glycoprotein-specific T and B cells cooperate to induce a Devic-like disease in mice. J Clin Invest 116(9):2393-402. [PubMed: 16955141] [MGI Ref ID J:114666]
Beyersdorf N; Ding X; Tietze JK; Hanke T. 2007. Characterization of mouse CD4 T cell subsets defined by expression of KLRG1. Eur J Immunol 37(12):3445-54. [PubMed: 18034419] [MGI Ref ID J:128529]
Bleier JI; Pillarisetty VG; Shah AB; DeMatteo RP. 2004. Increased and long-term generation of dendritic cells with reduced function from IL-6-deficient bone marrow. J Immunol 172(12):7408-16. [PubMed: 15187118] [MGI Ref ID J:90835]
Bochtler P; Kroger A; Schirmbeck R; Reimann J. 2008. Type I IFN-induced, NKT cell-mediated negative control of CD8 T cell priming by dendritic cells. J Immunol 181(3):1633-43. [PubMed: 18641299] [MGI Ref ID J:137877]
Bonasio R; Scimone ML; Schaerli P; Grabie N; Lichtman AH; von Andrian UH. 2006. Clonal deletion of thymocytes by circulating dendritic cells homing to the thymus. Nat Immunol 7(10):1092-100. [PubMed: 16951687] [MGI Ref ID J:112629]
Brannstrom J; Hassler S; Peltonen L; Herrmann B; Winqvist O. 2006. Defect internalization and tyrosine kinase activation in Aire deficient antigen presenting cells exposed to Candida albicans antigens. Clin Immunol 121(3):265-73. [PubMed: 16982213] [MGI Ref ID J:115940]
Bromley SK; Thomas SY; Luster AD. 2005. Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics. Nat Immunol 6(9):895-901. [PubMed: 16116469] [MGI Ref ID J:100486]
Brown DM; Dilzer AM; Meents DL; Swain SL. 2006. CD4 T cell-mediated protection from lethal influenza: perforin and antibody-mediated mechanisms give a one-two punch. J Immunol 177(5):2888-98. [PubMed: 16920924] [MGI Ref ID J:139502]
Buckler JL; Walsh PT; Porrett PM; Choi Y; Turka LA. 2006. Cutting edge: T cell requirement for CD28 costimulation is due to negative regulation of TCR signals by PTEN. J Immunol 177(7):4262-6. [PubMed: 16982858] [MGI Ref ID J:139334]
Burgdorf S; Kautz A; Bohnert V; Knolle PA; Kurts C. 2007. Distinct pathways of antigen uptake and intracellular routing in CD4 and CD8 T cell activation. Science 316(5824):612-6. [PubMed: 17463291] [MGI Ref ID J:121094]
Burgdorf S; Scholz C; Kautz A; Tampe R; Kurts C. 2008. Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation. Nat Immunol 9(5):558-66. [PubMed: 18376402] [MGI Ref ID J:134501]
Burmeister Y; Lischke T; Dahler AC; Mages HW; Lam KP; Coyle AJ; Kroczek RA; Hutloff A. 2008. ICOS controls the pool size of effector-memory and regulatory T cells. J Immunol 180(2):774-82. [PubMed: 18178815] [MGI Ref ID J:130966]
Calbo S; Delagreverie H; Arnoult C; Authier FJ; Tron F; Boyer O. 2008. Functional tolerance of CD8+ T cells induced by muscle-specific antigen expression. J Immunol 181(1):408-17. [PubMed: 18566407] [MGI Ref ID J:137402]
Caminschi I; Ahmet F; Heger K; Brady J; Nutt SL; Vremec D; Pietersz S; Lahoud MH; Schofield L; Hansen DS; O'Keeffe M; Smyth MJ; Bedoui S; Davey GM; Villadangos JA; Heath WR; Shortman K. 2007. Putative IKDCs are functionally and developmentally similar to natural killer cells, but not to dendritic cells. J Exp Med 204(11):2579-90. [PubMed: 17923506] [MGI Ref ID J:126110]
Caminschi I; Proietto AI; Ahmet F; Kitsoulis S; Shin Teh J; Lo JC; Rizzitelli A; Wu L; Vremec D; van Dommelen SL; Campbell IK; Maraskovsky E; Braley H; Davey GM; Mottram P; van de Velde N; Jensen K; Lew AM; Wright MD; Heath WR; Shortman K; Lahoud MH. 2008. The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement. Blood 112(8):3264-73. [PubMed: 18669894] [MGI Ref ID J:140214]
Cannons JL; Yu LJ; Hill B; Mijares LA; Dombroski D; Nichols KE; Antonellis A; Koretzky GA; Gardner K; Schwartzberg PL. 2004. SAP regulates T(H)2 differentiation and PKC-theta-mediated activation of NF-kappaB1. Immunity 21(5):693-706. [PubMed: 15539155] [MGI Ref ID J:93887]
Cannons JL; Yu LJ; Jankovic D; Crotty S; Horai R; Kirby M; Anderson S; Cheever AW; Sher A; Schwartzberg PL. 2006. SAP regulates T cell-mediated help for humoral immunity by a mechanism distinct from cytokine regulation. J Exp Med 203(6):1551-65. [PubMed: 16754717] [MGI Ref ID J:124375]
Carl JW Jr; Liu JQ; Joshi PS; El-Omrani HY; Yin L; Zheng X; Whitacre CC; Liu Y; Bai XF. 2008. Autoreactive T cells escape clonal deletion in the thymus by a CD24-dependent pathway. J Immunol 181(1):320-8. [PubMed: 18566397] [MGI Ref ID J:137407]
Castellino F; Huang AY; Altan-Bonnet G; Stoll S; Scheinecker C; Germain RN. 2006. Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction. Nature 440(7086):890-5. [PubMed: 16612374] [MGI Ref ID J:107629]
Castiglioni P; Gerloni M; Cortez-Gonzalez X; Zanetti M. 2005. CD8 T cell priming by B lymphocytes is CD4 help dependent. Eur J Immunol 35(5):1360-70. [PubMed: 15816014] [MGI Ref ID J:97807]
Castiglioni P; Hall de S; Jacovetty EL; Ingulli E; Zanetti M. 2008. Protection against Influenza A Virus by Memory CD8 T Cells Requires Reactivation by Bone Marrow-Derived Dendritic Cells. J Immunol 180(7):4956-64. [PubMed: 18354221] [MGI Ref ID J:133370]
Chai JG; Coe D; Chen D; Simpson E; Dyson J; Scott D. 2008. In vitro expansion improves in vivo regulation by CD4+CD25+ regulatory T cells. J Immunol 180(2):858-69. [PubMed: 18178825] [MGI Ref ID J:130962]
Chamoto K; Wakita D; Narita Y; Zhang Y; Noguchi D; Ohnishi H; Iguchi T; Sakai T; Ikeda H; Nishimura T. 2006. An essential role of antigen-presenting cell/T-helper type 1 cell-cell interactions in draining lymph node during complete eradication of class II-negative tumor tissue by T-helper type 1 cell therapy. Cancer Res 66(3):1809-17. [PubMed: 16452242] [MGI Ref ID J:106666]
Chen M; Wang YH; Wang Y; Huang L; Sandoval H; Liu YJ; Wang J. 2006. Dendritic cell apoptosis in the maintenance of immune tolerance. Science 311(5764):1160-4. [PubMed: 16497935] [MGI Ref ID J:105747]
Chen Z; Benoist C; Mathis D. 2005. How defects in central tolerance impinge on a deficiency in regulatory T cells. Proc Natl Acad Sci U S A 102(41):14735-40. [PubMed: 16203996] [MGI Ref ID J:102496]
Cornish AL; Davey GM; Metcalf D; Purton JF; Corbin JE; Greenhalgh CJ; Darwiche R; Wu L; Nicola NA; Godfrey DI; Heath WR; Hilton DJ; Alexander WS; Starr R. 2003. Suppressor of cytokine signaling-1 has IFN-gamma-independent actions in T cell homeostasis. J Immunol 170(2):878-86. [PubMed: 12517953] [MGI Ref ID J:127134]
Costalonga M; Zell T. 2007. Lipopolysaccharide enhances in vivo interleukin-2 production and proliferation by naive antigen-specific CD4 T cells via a Toll-like receptor 4-dependent mechanism. Immunology 122(1):124-30. [PubMed: 17484770] [MGI Ref ID J:125617]
Crawford A; Macleod M; Schumacher T; Corlett L; Gray D. 2006. Primary T cell expansion and differentiation in vivo requires antigen presentation by B cells. J Immunol 176(6):3498-506. [PubMed: 16517718] [MGI Ref ID J:129511]
Cruz A; Khader SA; Torrado E; Fraga A; Pearl JE; Pedrosa J; Cooper AM; Castro AG. 2006. Cutting edge: IFN-gamma regulates the induction and expansion of IL-17-producing CD4 T cells during mycobacterial infection. J Immunol 177(3):1416-20. [PubMed: 16849446] [MGI Ref ID J:137981]
Cunningham AF; Serre K; Toellner KM; Khan M; Alexander J; Brombacher F; MacLennan IC. 2004. Pinpointing IL-4-independent acquisition and IL-4-influenced maintenance of Th2 activity by CD4 T cells. Eur J Immunol 34(3):686-94. [PubMed: 14991598] [MGI Ref ID J:115477]
Czyzyk J; Chen HC; Bottomly K; Flavell RA. 2008. p21 Ras/impedes mitogenic signal propagation regulates cytokine production and migration in CD4 T cells. J Biol Chem 283(34):23004-15. [PubMed: 18577512] [MGI Ref ID J:140253]
Das G; Das J; Eynott P; Zhang Y; Bothwell AL; Van Kaer L; Shi Y. 2006. Pivotal roles of CD8+ T cells restricted by MHC class I-like molecules in autoimmune diseases. J Exp Med 203(12):2603-11. [PubMed: 17088432] [MGI Ref ID J:124622]
Datta SK; Redecke V; Prilliman KR; Takabayashi K; Corr M; Tallant T; DiDonato J; Dziarski R; Akira S; Schoenberger SP; Raz E. 2003. A subset of Toll-like receptor ligands induces cross-presentation by bone marrow-derived dendritic cells. J Immunol 170(8):4102-10. [PubMed: 12682240] [MGI Ref ID J:128788]
Dawicki W; Watts TH. 2004. Expression and function of 4-1BB during CD4 versus CD8 T cell responses in vivo. Eur J Immunol 34(3):743-51. [PubMed: 14991604] [MGI Ref ID J:115476]
Denning TL; Wang YC; Patel SR; Williams IR; Pulendran B. 2007. Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses. Nat Immunol 8(10):1086-94. [PubMed: 17873879] [MGI Ref ID J:125258]
Ding C; Wang L; Marroquin J; Yan J. 2008. Targeting of antigens to B cells augments antigen-specific T-cell responses and breaks immune tolerance to tumor-associated antigen MUC1. Blood 112(7):2817-25. [PubMed: 18669871] [MGI Ref ID J:140216]
Djuretic IM; Levanon D; Negreanu V; Groner Y; Rao A; Ansel KM. 2007. Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells. Nat Immunol 8(2):145-53. [PubMed: 17195845] [MGI Ref ID J:117861]
Doebis C; Siegmund K; Loddenkemper C; Lowe JB; Issekutz AC; Hamann A; Huehn J; Syrbe U. 2008. Cellular players and role of selectin ligands in leukocyte recruitment in a T-cell-initiated delayed-type hypersensitivity reaction. Am J Pathol 173(4):1067-76. [PubMed: 18755847] [MGI Ref ID J:139671]
Elias KM; Laurence A; Davidson TS; Stephens G; Kanno Y; Shevach EM; O'Shea JJ. 2008. Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway. Blood 111(3):1013-20. [PubMed: 17951529] [MGI Ref ID J:130685]
Erlebacher A; Vencato D; Price KA; Zhang D; Glimcher LH. 2007. Constraints in antigen presentation severely restrict T cell recognition of the allogeneic fetus. J Clin Invest 117(5):1399-411. [PubMed: 17446933] [MGI Ref ID J:122071]
Feuerer M; Eulenburg K; Loddenkemper C; Hamann A; Huehn J. 2006. Self-limitation of Th1-mediated inflammation by IFN-gamma. J Immunol 176(5):2857-63. [PubMed: 16493042] [MGI Ref ID J:129422]
Fillatreau S; Gray D. 2003. T cell accumulation in B cell follicles is regulated by dendritic cells and is independent of B cell activation. J Exp Med 197(2):195-206. [PubMed: 12538659] [MGI Ref ID J:124822]
Fontenot JD; Rasmussen JP; Williams LM; Dooley JL; Farr AG; Rudensky AY. 2005. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 22(3):329-41. [PubMed: 15780990] [MGI Ref ID J:97029]
Foulds KE; Rotte MJ; Paley MA; Singh B; Douek DC; Hill BJ; O'Shea JJ; Watford WT; Seder RA; Wu CY. 2008. IFN-gamma mediates the death of Th1 cells in a paracrine manner. J Immunol 180(2):842-9. [PubMed: 18178823] [MGI Ref ID J:130963]
Frick JS; Zahir N; Muller M; Kahl F; Bechtold O; Lutz MB; Kirschning CJ; Reimann J; Jilge B; Bohn E; Autenrieth IB. 2006. Colitogenic and non-colitogenic commensal bacteria differentially trigger DC maturation and Th cell polarization: an important role for IL-6. Eur J Immunol 36(6):1537-47. [PubMed: 16708404] [MGI Ref ID J:115077]
Fukunaga A; Khaskhely NM; Sreevidya CS; Byrne SN; Ullrich SE. 2008. Dermal dendritic cells, and not langerhans cells, play an essential role in inducing an immune response. J Immunol 180(5):3057-64. [PubMed: 18292528] [MGI Ref ID J:131539]
Gallegos AM; Bevan MJ. 2004. Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation. J Exp Med 200(8):1039-49. [PubMed: 15492126] [MGI Ref ID J:99681]
Gao Y; Grassi F; Ryan MR; Terauchi M; Page K; Yang X; Weitzmann MN; Pacifici R. 2007. IFN-gamma stimulates osteoclast formation and bone loss in vivo via antigen-driven T cell activation. J Clin Invest 117(1):122-32. [PubMed: 17173138] [MGI Ref ID J:117462]
Garcon F; Patton DT; Emery JL; Hirsch E; Rottapel R; Sasaki T; Okkenhaug K. 2008. CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer. Blood 111(3):1464-71. [PubMed: 18006698] [MGI Ref ID J:130753]
Gaspal FM; Kim MY; McConnell FM; Raykundalia C; Bekiaris V; Lane PJ. 2005. Mice deficient in OX40 and CD30 signals lack memory antibody responses because of deficient CD4 T cell memory. J Immunol 174(7):3891-6. [PubMed: 15778343] [MGI Ref ID J:97952]
Gavin MA; Clarke SR; Negrou E; Gallegos A; Rudensky A. 2002. Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivo. Nat Immunol 3(1):33-41. [PubMed: 11740498] [MGI Ref ID J:109187]
George-Chandy A; Nordstrom I; Nygren E; Jonsson IM; Postigo J; Collins LV; Eriksson K. 2008. Th17 development and autoimmune arthritis in the absence of reactive oxygen species. Eur J Immunol 38(4):1118-26. [PubMed: 18383034] [MGI Ref ID J:133769]
GeurtsvanKessel CH; Willart MA; van Rijt LS; Muskens F; Kool M; Baas C; Thielemans K; Bennett C; Clausen BE; Hoogsteden HC; Osterhaus AD; Rimmelzwaan GF; Lambrecht BN. 2008. Clearance of influenza virus from the lung depends on migratory langerin+CD11b- but not plasmacytoid dendritic cells. J Exp Med 205(7):1621-34. [PubMed: 18591406] [MGI Ref ID J:137452]
Graham DB; Stephenson LM; Lam SK; Brim K; Lee HM; Bautista J; Gilfillan S; Akilesh S; Fujikawa K; Swat W. 2007. An ITAM-signaling pathway controls cross-presentation of particulate but not soluble antigens in dendritic cells. J Exp Med 204(12):2889-97. [PubMed: 17984307] [MGI Ref ID J:128521]
Grayson MH; Cheung D; Rohlfing MM; Kitchens R; Spiegel DE; Tucker J; Battaile JT; Alevy Y; Yan L; Agapov E; Kim EY; Holtzman MJ. 2007. Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia. J Exp Med 204(11):2759-69. [PubMed: 17954569] [MGI Ref ID J:126124]
Grenningloh R; Miaw SC; Moisan J; Graves BJ; Ho IC. 2008. Role of Ets-1 phosphorylation in the effector function of Th cells. Eur J Immunol 38(6):1700-5. [PubMed: 18465773] [MGI Ref ID J:136194]
Grueter B; Petter M; Egawa T; Laule-Kilian K; Aldrian CJ; Wuerch A; Ludwig Y; Fukuyama H; Wardemann H; Waldschuetz R; Moroy T; Taniuchi I; Steimle V; Littman DR; Ehlers M. 2005. Runx3 regulates integrin alpha E/CD103 and CD4 expression during development of CD4-/CD8+ T cells. J Immunol 175(3):1694-705. [PubMed: 16034110] [MGI Ref ID J:107280]
Gu Y; Yang J; Ouyang X; Liu W; Li H; Yang J; Bromberg J; Chen SH; Mayer L; Unkeless JC; Xiong H. 2008. Interleukin 10 suppresses Th17 cytokines secreted by macrophages and T cells. Eur J Immunol 38(7):1807-13. [PubMed: 18506885] [MGI Ref ID J:137290]
Guarda G; Hons M; Soriano SF; Huang AY; Polley R; Martin-Fontecha A; Stein JV; Germain RN; Lanzavecchia A; Sallusto F. 2007. L-selectin-negative CCR7- effector and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells. Nat Immunol 8(7):743-52. [PubMed: 17529983] [MGI Ref ID J:123345]
Gupta S; Manicassamy S; Vasu C; Kumar A; Shang W; Sun Z. 2008. Differential requirement of PKC-theta in the development and function of natural regulatory T cells. Mol Immunol :. [PubMed: 18842300] [MGI Ref ID J:141128]
Hanninen A; Nurmela R; Maksimow M; Heino J; Jalkanen S; Kurts C. 2007. Islet beta-cell-specific T cells can use different homing mechanisms to infiltrate and destroy pancreatic islets. Am J Pathol 170(1):240-50. [PubMed: 17200197] [MGI Ref ID J:117052]
Hao S; Yuan J; Xiang J. 2007. Nonspecific CD4+ T cells with uptake of antigen-specific dendritic cell-released exosomes stimulate antigen-specific CD8+ CTL responses and long-term T cell memory. J Leukoc Biol 82(4):829-38. [PubMed: 17626150] [MGI Ref ID J:125204]
Hao S; Yuan J; Xu S; Munegowda MA; Deng Y; Gordon J; Xing Z; Xiang J. 2008. Antigen specificity acquisition of adoptive CD4+ regulatory T cells via acquired peptide-MHC class I complexes. J Immunol 181(4):2428-37. [PubMed: 18684933] [MGI Ref ID J:140189]
Hardenberg G; Fernandez L; Hendriks J; Chebli K; Jacquet C; Sitbon M; Hahne M; Medema JP. 2008. APRIL facilitates viral-induced erythroleukemia but is dispensable for T cell immunity and lymphomagenesis. J Leukoc Biol 84(2):380-8. [PubMed: 18483203] [MGI Ref ID J:138443]
Harris DP; Goodrich S; Gerth AJ; Peng SL; Lund FE. 2005. Regulation of IFN-gamma production by B effector 1 cells: essential roles for T-bet and the IFN-gamma receptor. J Immunol 174(11):6781-90. [PubMed: 15905519] [MGI Ref ID J:99038]
Havenar-Daughton C; Kolumam GA; Murali-Krishna K. 2006. Cutting Edge: The direct action of type I IFN on CD4 T cells is critical for sustaining clonal expansion in response to a viral but not a bacterial infection. J Immunol 176(6):3315-9. [PubMed: 16517698] [MGI Ref ID J:129538]
Hegde VL; Singh NP; Nagarkatti PS; Nagarkatti M. 2008. CD44 mobilization in allogeneic dendritic cell-T cell immunological synapse plays a key role in T cell activation. J Leukoc Biol 84(1):134-42. [PubMed: 18388297] [MGI Ref ID J:137751]
Helft J; Jacquet A; Joncker NT; Grandjean I; Dorothee G; Kissenpfennig A; Malissen B; Matzinger P; Lantz O. 2008. Antigen-specific T-T interactions regulate CD4 T-cell expansion. Blood 112(4):1249-58. [PubMed: 18539897] [MGI Ref ID J:138401]
Hida S; Tadachi M; Saito T; Taki S. 2005. Negative control of basophil expansion by IRF-2 critical for the regulation of Th1/Th2 balance. Blood 106(6):2011-7. [PubMed: 15914553] [MGI Ref ID J:118863]
Hinshaw-Makepeace J; Huston G; Fortner KA; Russell JQ; Holoch D; Swain S; Budd RC. 2008. c-FLIP(S) reduces activation of caspase and NF-kappaB pathways and decreases T cell survival. Eur J Immunol 38(1):54-63. [PubMed: 18081036] [MGI Ref ID J:130528]
Hintzen G; Ohl L; del Rio ML; Rodriguez-Barbosa JI; Pabst O; Kocks JR; Krege J; Hardtke S; Forster R. 2006. Induction of tolerance to innocuous inhaled antigen relies on a CCR7-dependent dendritic cell-mediated antigen transport to the bronchial lymph node. J Immunol 177(10):7346-54. [PubMed: 17082654] [MGI Ref ID J:140611]
Hisaeda H; Tetsutani K; Imai T; Moriya C; Tu L; Hamano S; Duan X; Chou B; Ishida H; Aramaki A; Shen J; Ishii KJ; Coban C; Akira S; Takeda K; Yasutomo K; Torii M; Himeno K. 2008. Malaria parasites require TLR9 signaling for immune evasion by activating regulatory T cells. J Immunol 180(4):2496-503. [PubMed: 18250459] [MGI Ref ID J:131983]
Hochweller K; Sweenie CH; Anderton SM. 2006. Circumventing tolerance at the T cell or the antigen-presenting cell surface: antibodies that ligate CD40 and OX40 have different effects. Eur J Immunol 36(2):389-96. [PubMed: 16402409] [MGI Ref ID J:113856]
Huang B; Pan PY; Li Q; Sato AI; Levy DE; Bromberg J; Divino CM; Chen SH. 2006. Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host. Cancer Res 66(2):1123-31. [PubMed: 16424049] [MGI Ref ID J:106544]
Huang H; Hao S; Li F; Ye Z; Yang J; Xiang J. 2007. CD4+ Th1 cells promote CD8+ Tc1 cell survival, memory response, tumor localization and therapy by targeted delivery of interleukin 2 via acquired pMHC I complexes. Immunology 120(2):148-59. [PubMed: 17274112] [MGI Ref ID J:122309]
Ikehara Y; Shiuchi N; Kabata-Ikehara S; Nakanishi H; Yokoyama N; Takagi H; Nagata T; Koide Y; Kuzushima K; Takahashi T; Tsujimura K; Kojima N. 2008. Effective induction of anti-tumor immune responses with oligomannose-coated liposome targeting to intraperitoneal phagocytic cells. Cancer Lett 260(1-2):137-145. [PubMed: 18077084] [MGI Ref ID J:130589]
Ishimaru N; Kishimoto H; Hayashi Y; Sprent J. 2006. Regulation of naive T cell function by the NF-kappaB2 pathway. Nat Immunol 7(7):763-72. [PubMed: 16732290] [MGI Ref ID J:112642]
Jacobsen EA; Ochkur SI; Pero RS; Taranova AG; Protheroe CA; Colbert DC; Lee NA; Lee JJ. 2008. Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells. J Exp Med 205(3):699-710. [PubMed: 18316417] [MGI Ref ID J:133142]
Jakubzick C; Tacke F; Llodra J; van Rooijen N; Randolph GJ. 2006. Modulation of dendritic cell trafficking to and from the airways. J Immunol 176(6):3578-84. [PubMed: 16517726] [MGI Ref ID J:129506]
Janssen E; Tabeta K; Barnes MJ; Rutschmann S; McBride S; Bahjat KS; Schoenberger SP; Theofilopoulos AN; Beutler B; Hoebe K. 2006. Efficient T cell activation via a Toll-Interleukin 1 Receptor-independent pathway. Immunity 24(6):787-99. [PubMed: 16782034] [MGI Ref ID J:113369]
Jenkins SJ; Perona-Wright G; MacDonald AS. 2008. Full development of Th2 immunity requires both innate and adaptive sources of CD154. J Immunol 180(12):8083-92. [PubMed: 18523272] [MGI Ref ID J:137237]
Jeon MS; Atfield A; Venuprasad K; Krawczyk C; Sarao R; Elly C; Yang C; Arya S; Bachmaier K; Su L; Bouchard D; Jones R; Gronski M; Ohashi P; Wada T; Bloom D; Fathman CG; Liu YC; Penninger JM. 2004. Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction. Immunity 21(2):167-77. [PubMed: 15308098] [MGI Ref ID J:93595]
Johansson-Lindbom B; Svensson M; Pabst O; Palmqvist C; Marquez G; Forster R; Agace WW. 2005. Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing. J Exp Med 202(8):1063-73. [PubMed: 16216890] [MGI Ref ID J:116817]
Kamperschroer C; Dibble JP; Meents DL; Schwartzberg PL; Swain SL. 2006. SAP is required for Th cell function and for immunity to influenza. J Immunol 177(8):5317-27. [PubMed: 17015717] [MGI Ref ID J:139442]
Kamperschroer C; Roberts DM; Zhang Y; Weng NP; Swain SL. 2008. SAP enables T cells to help B cells by a mechanism distinct from Th cell programming or CD40 ligand regulation. J Immunol 181(6):3994-4003. [PubMed: 18768854] [MGI Ref ID J:139100]
Kel JM; de Geus ED; van Stipdonk MJ; Drijfhout JW; Koning F; Nagelkerken L. 2008. Immunization with mannosylated peptide induces poor T cell effector functions despite enhanced antigen presentation. Int Immunol 20(1):117-27. [PubMed: 18024466] [MGI Ref ID J:130224]
Khader SA; Bell GK; Pearl JE; Fountain JJ; Rangel-Moreno J; Cilley GE; Shen F; Eaton SM; Gaffen SL; Swain SL; Locksley RM; Haynes L; Randall TD; Cooper AM. 2007. IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge. Nat Immunol 8(4):369-77. [PubMed: 17351619] [MGI Ref ID J:120806]
Khader SA; Partida-Sanchez S; Bell G; Jelley-Gibbs DM; Swain S; Pearl JE; Ghilardi N; Desauvage FJ; Lund FE; Cooper AM. 2006. Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection. J Exp Med 203(7):1805-15. [PubMed: 16818672] [MGI Ref ID J:124401]
Khader SA; Pearl JE; Sakamoto K; Gilmartin L; Bell GK; Jelley-Gibbs DM; Ghilardi N; deSauvage F; Cooper AM. 2005. IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-gamma responses if IL-12p70 is available. J Immunol 175(2):788-95. [PubMed: 16002675] [MGI Ref ID J:100721]
Khattri R; Cox T; Yasayko SA; Ramsdell F. 2003. An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat Immunol 4(4):337-42. [PubMed: 12612581] [MGI Ref ID J:128566]
Kim MY; Bekiaris V; McConnell FM; Gaspal FM; Raykundalia C; Lane PJ. 2005. OX40 signals during priming on dendritic cells inhibit CD4 T cell proliferation: IL-4 switches off OX40 signals enabling rapid proliferation of Th2 effectors. J Immunol 174(3):1433-7. [PubMed: 15661901] [MGI Ref ID J:96413]
King CG; Buckler JL; Kobayashi T; Hannah JR; Bassett G; Kim T; Pearce EL; Kim GG; Turka LA; Choi Y. 2008. Cutting edge: requirement for TRAF6 in the induction of T cell anergy. J Immunol 180(1):34-8. [PubMed: 18097000] [MGI Ref ID J:130882]
Kissenpfennig A; Ait-Yahia S; Clair-Moninot V; Stossel H; Badell E; Bordat Y; Pooley JL; Lang T; Prina E; Coste I; Gresser O; Renno T; Winter N; Milon G; Shortman K; Romani N; Lebecque S; Malissen B; Saeland S; Douillard P. 2005. Disruption of the langerin/CD207 gene abolishes Birbeck granules without a marked loss of Langerhans cell function. Mol Cell Biol 25(1):88-99. [PubMed: 15601833] [MGI Ref ID J:95147]
Kocks JR; Davalos-Misslitz AC; Hintzen G; Ohl L; Forster R. 2007. Regulatory T cells interfere with the development of bronchus-associated lymphoid tissue. J Exp Med 204(4):723-34. [PubMed: 17371929] [MGI Ref ID J:125613]
Kolsch U; Arndt B; Reinhold D; Lindquist JA; Juling N; Kliche S; Pfeffer K; Bruyns E; Schraven B; Simeoni L. 2006. Normal T-cell development and immune functions in TRIM-deficient mice. Mol Cell Biol 26(9):3639-48. [PubMed: 16612002] [MGI Ref ID J:108406]
Lambert KC; Curran EM; Judy BM; Milligan GN; Lubahn DB; Estes DM. 2005. Estrogen receptor alpha (ERalpha) deficiency in macrophages results in increased stimulation of CD4+ T cells while 17beta-estradiol acts through ERalpha to increase IL-4 and GATA-3 expression in CD4+ T cells independent of antigen presentation. J Immunol 175(9):5716-23. [PubMed: 16237062] [MGI Ref ID J:119342]
Lawlor KE; Campbell IK; Metcalf D; O'Donnell K; van Nieuwenhuijze A; Roberts AW; Wicks IP. 2004. Critical role for granulocyte colony-stimulating factor in inflammatory arthritis. Proc Natl Acad Sci U S A 101(31):11398-403. [PubMed: 15272075] [MGI Ref ID J:91780]
Lee JW; Epardaud M; Sun J; Becker JE; Cheng AC; Yonekura AR; Heath JK; Turley SJ. 2007. Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal self. Nat Immunol 8(2):181-90. [PubMed: 17195844] [MGI Ref ID J:117862]
Lee SW; Vella AT; Kwon BS; Croft M. 2005. Enhanced CD4 T cell responsiveness in the absence of 4-1BB. J Immunol 174(11):6803-8. [PubMed: 15905521] [MGI Ref ID J:99039]
Leibundgut-Landmann S; Gross O; Robinson MJ; Osorio F; Slack EC; Tsoni SV; Schweighoffer E; Tybulewicz V; Brown GD; Ruland J; Reis E Sousa C. 2007. Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. Nat Immunol 8(6):630-638. [PubMed: 17450144] [MGI Ref ID J:122424]
Li H; Oliver T; Jia W; He YW. 2006. Efficient dendritic cell priming of T lymphocytes depends on the extracellular matrix protein mindin. EMBO J 25(17):4097-107. [PubMed: 16917498] [MGI Ref ID J:112875]
Li M; Davey GM; Sutherland RM; Kurts C; Lew AM; Hirst C; Carbone FR; Heath WR. 2001. Cell-associated ovalbumin is cross-presented much more efficiently than soluble ovalbumin in vivo. J Immunol 166(10):6099-103. [PubMed: 11342628] [MGI Ref ID J:107361]
Li MO; Sanjabi S; Flavell RA. 2006. Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms. Immunity 25(3):455-71. [PubMed: 16973386] [MGI Ref ID J:113554]
Liang B; Workman C; Lee J; Chew C; Dale BM; Colonna L; Flores M; Li N; Schweighoffer E; Greenberg S; Tybulewicz V; Vignali D; Clynes R. 2008. Regulatory T Cells Inhibit Dendritic Cells by Lymphocyte Activation Gene-3 Engagement of MHC Class II. J Immunol 180(9):5916-26. [PubMed: 18424711] [MGI Ref ID J:134316]
Lind EF; Ahonen CL; Wasiuk A; Kosaka Y; Becher B; Bennett KA; Noelle RJ. 2008. Dendritic cells require the NF-kappaB2 pathway for cross-presentation of soluble antigens. J Immunol 181(1):354-63. [PubMed: 18566401] [MGI Ref ID J:137405]
Liu X; Manser T. 2005. Antinuclear antigen B cells that down-regulate surface B cell receptor during development to mature, follicular phenotype do not display features of anergy in vitro. J Immunol 174(8):4505-15. [PubMed: 15814671] [MGI Ref ID J:98165]
Loser K; Mehling A; Loeser S; Apelt J; Kuhn A; Grabbe S; Schwarz T; Penninger JM; Beissert S. 2006. Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells. Nat Med 12(12):1372-9. [PubMed: 17143276] [MGI Ref ID J:129593]
Lu L; Ikizawa K; Hu D; Werneck MB; Wucherpfennig KW; Cantor H. 2007. Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway. Immunity 26(5):593-604. [PubMed: 17509909] [MGI Ref ID J:123555]
Luthje K; Cramer SO; Ehrlich S; Veit A; Steeg C; Fleischer B; Bonin A; Breloer M. 2006. Transgenic expression of a CD83-immunoglobulin fusion protein impairs the development of immune-competent CD4-positive T cells. Eur J Immunol 36(8):2035-45. [PubMed: 16841299] [MGI Ref ID J:116024]
Maehr R; Hang HC; Mintern JD; Kim YM; Cuvillier A; Nishimura M; Yamada K; Shirahama-Noda K; Hara-Nishimura I; Ploegh HL. 2005. Asparagine endopeptidase is not essential for class II MHC antigen presentation but is required for processing of cathepsin L in mice. J Immunol 174(11):7066-74. [PubMed: 15905550] [MGI Ref ID J:99005]
Mahajan S; Cervera A; MacLeod M; Fillatreau S; Perona-Wright G; Meek S; Smith A; MacDonald A; Gray D. 2007. The role of ICOS in the development of CD4 T cell help and the reactivation of memory T cells. Eur J Immunol 37(7):1796-808. [PubMed: 17549732] [MGI Ref ID J:123477]
Martens GW; Arikan MC; Lee J; Ren F; Vallerskog T; Kornfeld H. 2008. Hypercholesterolemia impairs immunity to tuberculosis. Infect Immun 76(8):3464-72. [PubMed: 18505807] [MGI Ref ID J:139394]
Masuda A; Yoshida M; Shiomi H; Ikezawa S; Takagawa T; Tanaka H; Chinzei R; Ishida T; Morita Y; Kutsumi H; Inokuchi H; Wang S; Kobayashi K; Mizuno S; Nakamura A; Takai T; Blumberg RS; Azuma T. 2008. Fcgamma receptor regulation of Citrobacter rodentium infection. Infect Immun 76(4):1728-37. [PubMed: 18227164] [MGI Ref ID J:133533]
Mattei F; Schiavoni G; Borghi P; Venditti M; Canini I; Sestili P; Pietraforte I; Morse HC rd; Ramoni C; Belardelli F; Gabriele L. 2006. ICSBP/IRF-8 differentially regulates antigen uptake during dendritic-cell development and affects antigen presentation to CD4+ T cells. Blood 108(2):609-17. [PubMed: 16569763] [MGI Ref ID J:135753]
Maurice D; Hooper J; Lang G; Weston K. 2007. c-Myb regulates lineage choice in developing thymocytes via its target gene Gata3. EMBO J 26(15):3629-40. [PubMed: 17641686] [MGI Ref ID J:124106]
Mayer A; Denanglaire S; Viollet B; Leo O; Andris F. 2008. AMP-activated protein kinase regulates lymphocyte responses to metabolic stress but is largely dispensable for immune cell development and function. Eur J Immunol 38(4):948-56. [PubMed: 18350549] [MGI Ref ID J:133776]
Medoff BD; Seed B; Jackobek R; Zora J; Yang Y; Luster AD; Xavier R. 2006. CARMA1 is critical for the development of allergic airway inflammation in a murine model of asthma. J Immunol 176(12):7272-7. [PubMed: 16751370] [MGI Ref ID J:132226]
Mellor AL; Chandler P; Baban B; Hansen AM; Marshall B; Pihkala J; Waldmann H; Cobbold S; Adams E; Munn DH. 2004. Specific subsets of murine dendritic cells acquire potent T cell regulatory functions following CTLA4-mediated induction of indoleamine 2,3 dioxygenase. Int Immunol 16(10):1391-401. [PubMed: 15351783] [MGI Ref ID J:93639]
Meylan F; Davidson TS; Kahle E; Kinder M; Acharya K; Jankovic D; Bundoc V; Hodges M; Shevach EM; Keane-Myers A; Wang EC; Siegel RM. 2008. The TNF-family receptor DR3 is essential for diverse T cell-mediated inflammatory diseases. Immunity 29(1):79-89. [PubMed: 18571443] [MGI Ref ID J:137671]
Michna L; Wagner GC; Lou YR; Xie JG; Peng QY; Lin Y; Carlson K; Shih WJ; Conney AH; Lu YP. 2006. Inhibitory effects of voluntary running wheel exercise on UVB-induced skin carcinogenesis in SKH-1 mice. Carcinogenesis 27(10):2108-15. [PubMed: 16699173] [MGI Ref ID J:113354]
Mikhak Z; Fleming CM; Medoff BD; Thomas SY; Tager AM; Campanella GS; Luster AD. 2006. STAT1 in peripheral tissue differentially regulates homing of antigen-specific Th1 and Th2 cells. J Immunol 176(8):4959-67. [PubMed: 16585592] [MGI Ref ID J:131153]
Missy K; Hu B; Schilling K; Harenberg A; Sakk V; Kuchenbecker K; Kutsche K; Fischer KD. 2008. AlphaPIX Rho GTPase guanine nucleotide exchange factor regulates lymphocyte functions and antigen receptor signaling. Mol Cell Biol 28(11):3776-89. [PubMed: 18378701] [MGI Ref ID J:137269]
Miyake Y; Asano K; Kaise H; Uemura M; Nakayama M; Tanaka M. 2007. Critical role of macrophages in the marginal zone in the suppression of immune responses to apoptotic cell-associated antigens. J Clin Invest 117(8):2268-78. [PubMed: 17657313] [MGI Ref ID J:123958]
Nagaishi T; Pao L; Lin SH; Iijima H; Kaser A; Qiao SW; Chen Z; Glickman J; Najjar SM; Nakajima A; Neel BG; Blumberg RS. 2006. SHP1 phosphatase-dependent T cell inhibition by CEACAM1 adhesion molecule isoforms. Immunity 25(5):769-81. [PubMed: 17081782] [MGI Ref ID J:116136]
Nakae S; Iwakura Y; Suto H; Galli SJ. 2007. Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17. J Leukoc Biol 81(5):1258-68. [PubMed: 17307864] [MGI Ref ID J:121718]
Nakayama T; Kasprowicz DJ; Yamashita M; Schubert LA; Gillard G; Kimura M; Didierlaurent A; Koseki H; Ziegler SF. 2002. The generation of mature, single-positive thymocytes in vivo is dysregulated by CD69 blockade or overexpression. J Immunol 168(1):87-94. [PubMed: 11751950] [MGI Ref ID J:131006]
Nurieva R; Thomas S; Nguyen T; Martin-Orozco N; Wang Y; Kaja MK; Yu XZ; Dong C. 2006. T-cell tolerance or function is determined by combinatorial costimulatory signals. EMBO J 25(11):2623-33. [PubMed: 16724117] [MGI Ref ID J:109521]
Ohl L; Mohaupt M; Czeloth N; Hintzen G; Kiafard Z; Zwirner J; Blankenstein T; Henning G; Forster R. 2004. CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions. Immunity 21(2):279-88. [PubMed: 15308107] [MGI Ref ID J:93892]
Okada T; Miller MJ; Parker I; Krummel MF; Neighbors M; Hartley SB; O'Garra A; Cahalan MD; Cyster JG. 2005. Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells. PLoS Biol 3(6):e150. [PubMed: 15857154] [MGI Ref ID J:99611]
Okkenhaug K; Patton DT; Bilancio A; Garcon F; Rowan WC; Vanhaesebroeck B. 2006. The p110delta isoform of phosphoinositide 3-kinase controls clonal expansion and differentiation of Th cells. J Immunol 177(8):5122-8. [PubMed: 17015696] [MGI Ref ID J:139452]
Orinska Z; Bulanova E; Budagian V; Metz M; Maurer M; Bulfone-Paus S. 2005. TLR3-induced activation of mast cells modulates CD8+ T-cell recruitment. Blood 106(3):978-87. [PubMed: 15840693] [MGI Ref ID J:117318]
Ouyang W; Ranganath SH; Weindel K; Bhattacharya D; Murphy TL; Sha WC; Murphy KM. 1998. Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism. Immunity 9(5):745-55. [PubMed: 9846495] [MGI Ref ID J:51355]
Panattoni M; Sanvito F; Basso V; Doglioni C; Casorati G; Montini E; Bender JR; Mondino A; Pardi R. 2008. Targeted inactivation of the COP9 signalosome impairs multiple stages of T cell development. J Exp Med 205(2):465-77. [PubMed: 18268034] [MGI Ref ID J:132114]
Pape KA; Kouskoff V; Nemazee D; Tang HL; Cyster JG; Tze LE; Hippen KL; Behrens TW; Jenkins MK. 2003. Visualization of the genesis and fate of isotype-switched B cells during a primary immune response. J Exp Med 197(12):1677-87. [PubMed: 12796466] [MGI Ref ID J:116662]
Parameswaran N; Samuvel DJ; Kumar R; Thatai S; Bal V; Rath S; George A. 2004. Oral tolerance in T cells is accompanied by induction of effector function in lymphoid organs after systemic immunization. Infect Immun 72(7):3803-11. [PubMed: 15213121] [MGI Ref ID J:90986]
Pargmann D; Yucel R; Kosan C; Saba I; Klein-Hitpass L; Schimmer S; Heyd F; Dittmer U; Moroy T. 2007. Differential impact of the transcriptional repressor Gfi1 on mature CD4(+) and CD8(+) T lymphocyte function. Eur J Immunol 37(12):3551-63. [PubMed: 18034420] [MGI Ref ID J:128528]
Park JE; Wu DY; Prendes M; Lu SX; Ragupathi G; Schrantz N; Chapman PB. 2008. Fine specificity of natural killer T cells against GD3 ganglioside and identification of GM3 as an inhibitory natural killer T-cell ligand. Immunology 123(1):145-55. [PubMed: 18154620] [MGI Ref ID J:135461]
Park SJ; Nakagawa T; Kitamura H; Atsumi T; Kamon H; Sawa S; Kamimura D; Ueda N; Iwakura Y; Ishihara K; Murakami M; Hirano T. 2004. IL-6 regulates in vivo dendritic cell differentiation through STAT3 activation. J Immunol 173(6):3844-54. [PubMed: 15356132] [MGI Ref ID J:92764]
Perrigoue JG; Li J; Zaph C; Goldschmidt M; Scott P; de Sauvage FJ; Pearce EJ; Ghilardi N; Artis D. 2007. IL-31-IL-31R interactions negatively regulate type 2 inflammation in the lung. J Exp Med 204(3):481-7. [PubMed: 17353366] [MGI Ref ID J:123198]
Piconese S; Valzasina B; Colombo MP. 2008. OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection. J Exp Med 205(4):825-39. [PubMed: 18362171] [MGI Ref ID J:134000]
Pradhan S; Genebriera J; Denning WL; Felix K; Elmets CA; Timares L. 2006. CD4 T cell-induced, bid-dependent apoptosis of cutaneous dendritic cells regulates T cell expansion and immune responses. J Immunol 177(9):5956-67. [PubMed: 17056520] [MGI Ref ID J:140532]
Price JD; Simpfendorfer KR; Mantena RR; Holden J; Heath WR; van Rooijen N; Strugnell RA; Wijburg OL. 2007. Gamma interferon-independent effects of interleukin-12 on immunity to Salmonella enterica serovar Typhimurium. Infect Immun 75(12):5753-62. [PubMed: 17875635] [MGI Ref ID J:127653]
Pulendran B; Kumar P; Cutler CW; Mohamadzadeh M; Van Dyke T; Banchereau J. 2001. Lipopolysaccharides from distinct pathogens induce different classes of immune responses in vivo. J Immunol 167(9):5067-76. [PubMed: 11673516] [MGI Ref ID J:108300]
Qi H; Cannons JL; Klauschen F; Schwartzberg PL; Germain RN. 2008. SAP-controlled T-B cell interactions underlie germinal centre formation. Nature 455(7214):764-9. [PubMed: 18843362] [MGI Ref ID J:140086]
Qiao M; Thornton AM; Shevach EM. 2007. CD4+ CD25+ [corrected] regulatory T cells render naive CD4+ CD25- T cells anergic and suppressive. Immunology 120(4):447-55. [PubMed: 17244157] [MGI Ref ID J:122637]
Radhakrishnan S; Celis E; Pease LR. 2005. B7-DC cross-linking restores antigen uptake and augments antigen-presenting cell function by matured dendritic cells. Proc Natl Acad Sci U S A 102(32):11438-43. [PubMed: 16061819] [MGI Ref ID J:100468]
Reinhardt RL; Hong S; Kang SJ; Wang ZE; Locksley RM. 2006. Visualization of IL-12/23p40 in vivo reveals immunostimulatory dendritic cell migrants that promote Th1 differentiation. J Immunol 177(3):1618-27. [PubMed: 16849470] [MGI Ref ID J:112745]
Roberts JM; Yang J; Ronchese F. 2004. IL-4 deficiency does not impair the ability of dendritic cells to initiate CD4+ and CD8+ T cell responses in vivo. Int Immunol 16(10):1451-8. [PubMed: 15326095] [MGI Ref ID J:93655]
Ruby CE; Montler R; Zheng R; Shu S; Weinberg AD. 2008. IL-12 is required for anti-OX40-mediated CD4 T cell survival. J Immunol 180(4):2140-8. [PubMed: 18250420] [MGI Ref ID J:131920]
Ruckert R; Bulfone-Paus S; Brandt K. 2008. Interleukin-21 stimulates antigen uptake, protease activity, survival and induction of CD4+ T cell proliferation by murine macrophages. Clin Exp Immunol 151(3):487-95. [PubMed: 18190607] [MGI Ref ID J:131600]
Rudd ML; Tua-Smith A; Straus DB. 2006. Lck SH3 domain function is required for T-cell receptor signals regulating thymocyte development. Mol Cell Biol 26(21):7892-900. [PubMed: 16923964] [MGI Ref ID J:114660]
Sait LC; Galic M; Price JD; Simpfendorfer KR; Diavatopoulos DA; Uren TK; Janssen PH; Wijburg OL; Strugnell RA. 2007. Secretory antibodies reduce systemic antibody responses against the gastrointestinal commensal flora. Int Immunol 19(3):257-65. [PubMed: 17255112] [MGI Ref ID J:118689]
Sakowicz-Burkiewicz M; Nishanth G; Helmuth U; Drogemuller K; Busch DH; Utermohlen O; Naumann M; Deckert M; Schluter D. 2008. Protein kinase C-theta critically regulates the proliferation and survival of pathogen-specific T cells in murine listeriosis. J Immunol 180(8):5601-12. [PubMed: 18390745] [MGI Ref ID J:134249]
Sapoznikov A; Fischer JA; Zaft T; Krauthgamer R; Dzionek A; Jung S. 2007. Organ-dependent in vivo priming of naive CD4+, but not CD8+, T cells by plasmacytoid dendritic cells. J Exp Med 204(8):1923-33. [PubMed: 17646404] [MGI Ref ID J:125954]
Sawatani Y; Miyamoto T; Nagai S; Maruya M; Imai J; Miyamoto K; Fujita N; Ninomiya K; Suzuki T; Iwasaki R; Toyama Y; Shinohara M; Koyasu S; Suda T. 2008. The role of DC-STAMP in maintenance of immune tolerance through regulation of dendritic cell function. Int Immunol 20(10):1259-68. [PubMed: 18653699] [MGI Ref ID J:140227]
Scheibner KA; Lutz MA; Boodoo S; Fenton MJ; Powell JD; Horton MR. 2006. Hyaluronan fragments act as an endogenous danger signal by engaging TLR2. J Immunol 177(2):1272-81. [PubMed: 16818787] [MGI Ref ID J:135038]
Sharma R; Ju AC; Kung JT; Fu SM; Ju ST. 2008. Rapid and selective expansion of nonclonotypic T cells in regulatory T cell-deficient, foreign antigen-specific TCR-transgenic scurfy mice: antigen-dependent expansion and TCR analysis. J Immunol 181(10):6934-41. [PubMed: 18981113] [MGI Ref ID J:140943]
Shen T; Kim S; Do JS; Wang L; Lantz C; Urban JF; Le Gros G; Min B. 2008. T cell-derived IL-3 plays key role in parasite infection-induced basophil production but is dispensable for in vivo basophil survival. Int Immunol 20(9):1201-9. [PubMed: 18632726] [MGI Ref ID J:139047]
Shi FD; Flodstrom M; Kim SH; Pakala S; Cleary M; Ljunggren HG; Sarvetnick N. 2001. Control of the autoimmune response by type 2 nitric oxide synthase. J Immunol 167(5):3000-6. [PubMed: 11509651] [MGI Ref ID J:119462]
Shi M; Lin TH; Appell KC; Berg LJ. 2008. Janus-kinase-3-dependent signals induce chromatin remodeling at the Ifng locus during T helper 1 cell differentiation. Immunity 28(6):763-73. [PubMed: 18549798] [MGI Ref ID J:137735]
Shi Z; Rifa'i M; Lee YH; Shiku H; Isobe K; Suzuki H. 2008. Importance of CD80/CD86-CD28 interactions in the recognition of target cells by CD8+CD122+ regulatory T cells. Immunology 124(1):121-8. [PubMed: 18205792] [MGI Ref ID J:136528]
Shinohara ML; Kim JH; Garcia VA; Cantor H. 2008. Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin. Immunity 29(1):68-78. [PubMed: 18619869] [MGI Ref ID J:137879]
Shui JW; Hu MC; Tan TH. 2007. Conditional knockout mice reveal an essential role of protein phosphatase 4 in thymocyte development and pre-T-cell receptor signaling. Mol Cell Biol 27(1):79-91. [PubMed: 17060460] [MGI Ref ID J:117684]
Simeoni L; Posevitz V; Kolsch U; Meinert I; Bruyns E; Pfeffer K; Reinhold D; Schraven B. 2005. The transmembrane adapter protein SIT regulates thymic development and peripheral T-cell functions. Mol Cell Biol 25(17):7557-68. [PubMed: 16107703] [MGI Ref ID J:100408]
Skokos D; Nussenzweig MC. 2007. CD8- DCs induce IL-12-independent Th1 differentiation through Delta 4 Notch-like ligand in response to bacterial LPS. J Exp Med 204(7):1525-31. [PubMed: 17576775] [MGI Ref ID J:125873]
Song J; So T; Croft M. 2008. Activation of NF-kappaB1 by OX40 contributes to antigen-driven T cell expansion and survival. J Immunol 180(11):7240-8. [PubMed: 18490723] [MGI Ref ID J:136337]
Sporri R; Reis e Sousa C. 2005. Inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4+ T cell populations lacking helper function. Nat Immunol 6(2):163-70. [PubMed: 15654341] [MGI Ref ID J:95652]
Stenstad H; Ericsson A; Johansson-Lindbom B; Svensson M; Marsal J; Mack M; Picarella D; Soler D; Marquez G; Briskin M; Agace WW. 2006. Gut-associated lymphoid tissue-primed CD4+ T cells display CCR9-dependent and -independent homing to the small intestine. Blood 107(9):3447-54. [PubMed: 16391017] [MGI Ref ID J:132559]
Strainic MG; Liu J; Huang D; An F; Lalli PN; Muqim N; Shapiro VS; Dubyak GR; Heeger PS; Medof ME. 2008. Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells. Immunity 28(3):425-35. [PubMed: 18328742] [MGI Ref ID J:132942]
Su MA; Giang K; Zumer K; Jiang H; Oven I; Rinn JL; Devoss JJ; Johannes KP; Lu W; Gardner J; Chang A; Bubulya P; Chang HY; Peterlin BM; Anderson MS. 2008. Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire. J Clin Invest 118(5):1712-26. [PubMed: 18414681] [MGI Ref ID J:135154]
Summers-DeLuca LE; McCarthy DD; Cosovic B; Ward LA; Lo CC; Scheu S; Pfeffer K; Gommerman JL. 2007. Expression of lymphotoxin-alphabeta on antigen-specific T cells is required for DC function. J Exp Med 204(5):1071-81. [PubMed: 17452522] [MGI Ref ID J:125738]
Sun CM; Deriaud E; Leclerc C; Lo-Man R. 2005. Upon TLR9 signaling, CD5+ B cells control the IL-12-dependent Th1-priming capacity of neonatal DCs. Immunity 22(4):467-77. [PubMed: 15845451] [MGI Ref ID J:97988]
Suzuki K; Okuno T; Yamamoto M; Pasterkamp RJ; Takegahara N; Takamatsu H; Kitao T; Takagi J; Rennert PD; Kolodkin AL; Kumanogoh A; Kikutani H. 2007. Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin. Nature 446(7136):680-4. [PubMed: 17377534] [MGI Ref ID J:121431]
Suzuki N; Suzuki S; Millar DG; Unno M; Hara H; Calzascia T; Yamasaki S; Yokosuka T; Chen NJ; Elford AR; Suzuki J; Takeuchi A; Mirtsos C; Bouchard D; Ohashi PS; Yeh WC; Saito T. 2006. A critical role for the innate immune signaling molecule IRAK-4 in T cell activation. Science 311(5769):1927-32. [PubMed: 16574867] [MGI Ref ID J:107198]
Suzuki S; Honma K; Matsuyama T; Suzuki K; Toriyama K; Akitoyo I; Yamamoto K; Suematsu T; Nakamura M; Yui K; Kumatori A. 2004. Critical roles of interferon regulatory factor 4 in CD11bhighCD8alpha- dendritic cell development. Proc Natl Acad Sci U S A 101(24):8981-6. [PubMed: 15184678] [MGI Ref ID J:91043]
Takegahara N; Takamatsu H; Toyofuku T; Tsujimura T; Okuno T; Yukawa K; Mizui M; Yamamoto M; Prasad DV; Suzuki K; Ishii M; Terai K; Moriya M; Nakatsuji Y; Sakoda S; Sato S; Akira S; Takeda K; Inui M; Takai T; Ikawa M; Okabe M; Kumanogoh A; Kikutani H. 2006. Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis. Nat Cell Biol 8(6):615-22. [PubMed: 16715077] [MGI Ref ID J:110786]
Tamura C; Nakazawa M; Kasahara M; Hotta C; Yoshinari M; Sato F; Minami M. 2006. Impaired function of dendritic cells in alymphoplasia (aly/aly) mice for expansion of CD25+CD4+ regulatory T cells. Autoimmunity 39(6):445-53. [PubMed: 17060023] [MGI Ref ID J:128211]
Tamura T; Tailor P; Yamaoka K; Kong HJ; Tsujimura H; O'Shea JJ; Singh H; Ozato K. 2005. IFN regulatory factor-4 and -8 govern dendritic cell subset development and their functional diversity. J Immunol 174(5):2573-81. [PubMed: 15728463] [MGI Ref ID J:97716]
Tao J; Segal BH; Eppolito C; Li Q; Dennis CG; Youn R; Shrikant PA. 2006. Aspergillus fumigatus extract differentially regulates antigen-specific CD4+ and CD8+ T cell responses to promote host immunity. J Leukoc Biol 80(3):529-37. [PubMed: 16793916] [MGI Ref ID J:112577]
Telusma G; Datta S; Mihajlov I; Ma W; Li J; Yang H; Newman W; Messmer BT; Minev B; Schmidt-Wolf IG; Tracey KJ; Chiorazzi N; Messmer D. 2006. Dendritic cell activating peptides induce distinct cytokine profiles. Int Immunol 18(11):1563-73. [PubMed: 16966494] [MGI Ref ID J:114952]
Thoeni G; Stoitzner P; Brandacher G; Romani N; Heufler C; Werner-Felmayer G; Werner ER. 2005. Tetrahydro-4-aminobiopterin attenuates dendritic cell-induced T cell priming independently from inducible nitric oxide synthase. J Immunol 174(12):7584-91. [PubMed: 15944258] [MGI Ref ID J:100788]
Thomas MS; Mitchell JS; Denucci CC; Martin AL; Shimizu Y. 2008. The p110{gamma} isoform of phosphatidylinositol 3-kinase regulates migration of effector CD4 T lymphocytes into peripheral inflammatory sites. J Leukoc Biol 84(3):814-23. [PubMed: 18523230] [MGI Ref ID J:138164]
Tsukada J; Ozaki A; Hanada T; Chinen T; Abe R; Yoshimura A; Kubo M. 2005. The role of suppressor of cytokine signaling 1 as a negative regulator for aberrant expansion of CD8{alpha}+ dendritic cell subset. Int Immunol 17(9):1167-78. [PubMed: 16091384] [MGI Ref ID J:100705]
Turley SJ; Lee JW; Dutton-Swain N; Mathis D; Benoist C. 2005. Endocrine self and gut non-self intersect in the pancreatic lymph nodes. Proc Natl Acad Sci U S A 102(49):17729-33. [PubMed: 16317068] [MGI Ref ID J:104385]
Uematsu S; Fujimoto K; Jang MH; Yang BG; Jung YJ; Nishiyama M; Sato S; Tsujimura T; Yamamoto M; Yokota Y; Kiyono H; Miyasaka M; Ishii KJ; Akira S. 2008. Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5. Nat Immunol 9(7):769-76. [PubMed: 18516037] [MGI Ref ID J:137710]
Venuprasad K; Elly C; Gao M; Salek-Ardakani S; Harada Y; Luo JL; Yang C; Croft M; Inoue K; Karin M; Liu YC. 2006. Convergence of Itch-induced ubiquitination with MEKK1-JNK signaling in Th2 tolerance and airway inflammation. J Clin Invest 116(4):1117-26. [PubMed: 16557301] [MGI Ref ID J:107801]
Vogelzang A; McGuire HM; Yu D; Sprent J; Mackay CR; King C. 2008. A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity 29(1):127-37. [PubMed: 18602282] [MGI Ref ID J:137867]
Wall EM; Milne K; Martin ML; Watson PH; Theiss P; Nelson BH. 2007. Spontaneous mammary tumors differ widely in their inherent sensitivity to adoptively transferred T cells. Cancer Res 67(13):6442-50. [PubMed: 17616705] [MGI Ref ID J:122846]
Walzer T; Brawand P; Swart D; Tocker J; De Smedt T. 2005. No defect in T-cell priming, secondary response, or tolerance induction in response to inhaled antigens in Fms-like tyrosine kinase 3 ligand-deficient mice. J Allergy Clin Immunol 115(1):192-9. [PubMed: 15637568] [MGI Ref ID J:105326]
Walzer T; Galibert L; De Smedt T. 2005. Dendritic cell function in mice lacking Plexin C1. Int Immunol 17(7):943-50. [PubMed: 15967782] [MGI Ref ID J:99972]
Wang Y; Shibuya K; Yamashita Y; Shirakawa J; Shibata K; Kai H; Yokosuka T; Saito T; Honda S; Tahara-Hanaoka S; Shibuya A. 2008. LFA-1 decreases the antigen dose for T cell activation in vivo. Int Immunol 20(9):1119-27. [PubMed: 18644832] [MGI Ref ID J:139027]
Warger T; Osterloh P; Rechtsteiner G; Fassbender M; Heib V; Schmid B; Schmitt E; Schild H; Radsak MP. 2006. Synergistic activation of dendritic cells by combined Toll-like receptor ligation induces superior CTL responses in vivo. Blood 108(2):544-50. [PubMed: 16537810] [MGI Ref ID J:135762]
Watanabe T; Kitani A; Murray PJ; Wakatsuki Y; Fuss IJ; Strober W. 2006. Nucleotide binding oligomerization domain 2 deficiency leads to dysregulated TLR2 signaling and induction of antigen-specific colitis. Immunity 25(3):473-85. [PubMed: 16949315] [MGI Ref ID J:113450]
Winau F; Hegasy G; Weiskirchen R; Weber S; Cassan C; Sieling PA; Modlin RL; Liblau RS; Gressner AM; Kaufmann SH. 2007. Ito cells are liver-resident antigen-presenting cells for activating T cell responses. Immunity 26(1):117-29. [PubMed: 17239632] [MGI Ref ID J:118321]
Winau F; Sponaas AM; Weber S; Schwierzeck V; Winter R; Hurwitz R; Kaufmann SH. 2005. Scant activation of CD8 T cells by antigen loaded on heat shock protein. Eur J Immunol 35(4):1046-55. [PubMed: 15739167] [MGI Ref ID J:97820]
Winau F; Weber S; Sad S; de Diego J; Hoops SL; Breiden B; Sandhoff K; Brinkmann V; Kaufmann SH; Schaible UE. 2006. Apoptotic vesicles crossprime CD8 T cells and protect against tuberculosis. Immunity 24(1):105-17. [PubMed: 16413927] [MGI Ref ID J:113317]
Wingender G; Berg M; Jungerkes F; Diehl L; Sullivan BA; Kronenberg M; Limmer A; Knolle PA. 2006. Immediate antigen-specific effector functions by TCR-transgenic CD8+ NKT cells. Eur J Immunol 36(3):570-82. [PubMed: 16506291] [MGI Ref ID J:114826]
Wittke A; Chang A; Froicu M; Harandi OF; Weaver V; August A; Paulson RF; Cantorna MT. 2007. Vitamin D receptor expression by the lung micro-environment is required for maximal induction of lung inflammation. Arch Biochem Biophys 460(2):306-13. [PubMed: 17224129] [MGI Ref ID J:123350]
Wong P; Goldrath AW; Rudensky AY. 2000. Competition for specific intrathymic ligands limits positive selection in a TCR transgenic model of CD4+ T cell development. J Immunol 164(12):6252-9. [PubMed: 10843678] [MGI Ref ID J:125548]
Workman CJ; Cauley LS; Kim IJ; Blackman MA; Woodland DL; Vignali DA. 2004. Lymphocyte activation gene-3 (CD223) regulates the size of the expanding T cell population following antigen activation in vivo. J Immunol 172(9):5450-5. [PubMed: 15100286] [MGI Ref ID J:89653]
Workman CJ; Vignali DA. 2005. Negative regulation of T cell homeostasis by lymphocyte activation gene-3 (CD223). J Immunol 174(2):688-95. [PubMed: 15634887] [MGI Ref ID J:95840]
Workman CJ; Vignali DA. 2003. The CD4-related molecule, LAG-3 (CD223), regulates the expansion of activated T cells. Eur J Immunol 33(4):970-9. [PubMed: 12672063] [MGI Ref ID J:82865]
Xiang J; Huang H; Liu Y. 2005. A new dynamic model of CD8+ T effector cell responses via CD4+ T helper-antigen-presenting cells. J Immunol 174(12):7497-505. [PubMed: 15944248] [MGI Ref ID J:100792]
Xiao Y; Peperzak V; Keller AM; Borst J. 2008. CD27 instructs CD4+ T cells to provide help for the memory CD8+ T cell response after protein immunization. J Immunol 181(2):1071-82. [PubMed: 18606659] [MGI Ref ID J:137472]
Yamaoka K; Min B; Zhou YJ; Paul WE; O'shea JJ. 2005. Jak3 negatively regulates dendritic-cell cytokine production and survival. Blood 106(9):3227-33. [PubMed: 16020505] [MGI Ref ID J:123902]
Yang XO; Nurieva R; Martinez GJ; Kang HS; Chung Y; Pappu BP; Shah B; Chang SH; Schluns KS; Watowich SS; Feng XH; Jetten AM; Dong C. 2008. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity 29(1):44-56. [PubMed: 18585065] [MGI Ref ID J:137851]
Yang Z; Fuss IJ; Watanabe T; Asano N; Davey MP; Rosenbaum JT; Strober W; Kitani A. 2007. NOD2 transgenic mice exhibit enhanced MDP-mediated down-regulation of TLR2 responses and resistance to colitis induction. Gastroenterology 133(5):1510-21. [PubMed: 17915219] [MGI Ref ID J:130116]
Ye Z; Ahmed KA; Huang J; Xie Y; Munegowda MA; Xiang J. 2008. T cell precursor frequency differentially affects CTL responses under different immune conditions. Biochem Biophys Res Commun 367(2):427-34. [PubMed: 18178159] [MGI Ref ID J:131030]
Yoshida M; Kobayashi K; Kuo TT; Bry L; Glickman JN; Claypool SM; Kaser A; Nagaishi T; Higgins DE; Mizoguchi E; Wakatsuki Y; Roopenian DC; Mizoguchi A; Lencer WI; Blumberg RS. 2006. Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria. J Clin Invest 116(8):2142-2151. [PubMed: