Strain Name:

B6.Cg-Selplgtm1Fur/J

Stock Number:

004201

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Availability:

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Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names B6.Cg-Selpltm1Fur/J    (Changed: 30-MAY-07 )
Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
 
Donating Investigator Bruce Furie,   Beth Israel Deaconess Med Cntr (Harvard)

Description
Mice that are homozygous for the targeted mutation are viable, normal in size and do not display any gross physical or behavioral abnormalities. No targeted allele product (mRNA or protein) is detected by Northern blot or immunoassay. Mutant mice exhibit mild neutrophilia. Impaired early neutrophil migration in thioglycolate-induced peritonitis is followed by a delayed recovery to nearly normal levels. Although early trauma-induced leukocyte adhesion and migration is greatly reduced and in vivo leukocyte rolling (leukocyte-endothelial cell interaction) in postcapillary venules is severely decreased, cytokine-induced/E selectin-mediated leukocyte rolling is only slightly reduced in the mutant mice. This mutant mouse strain represents a model that may be useful in studies of leukocyte adhesion and migration in the inflammatory response.

Development
A targeting vector containing neomycin resistance and herpes simplex virus thymidine kinase genes was used to disrupt a 5' portion of the Selpl coding sequence. The construct was electroporated into STOCK(129/Sv(75%),C57BL/6J(20%),SJL(5%)) derived WW6 embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6 blastocysts. The resulting chimeric male animals were backcrossed to C57BL/6J mice. Heterozygotes were bred to generate homozygotes.

SNP (single nucleotide polymorphism) analysis performed by The Jackson Laboratory revealed that the Donating Investigator used C57BL/6N (2 of 5 markers segregating) in the development of the strain. Upon arrival at The Jackson Laboratory, the mice were crossed to C57BL/6J at least once to establish the colony.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Selplg
006336   B6.129-Selplgtm1Rpmc/J
View Strains carrying other alleles of Selplg     (1 strain)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Selplgtm1Fur/Selplgtm1Fur

        involves: 129/Sv * C57BL/6J * SJL
  • immune system phenotype
  • abnormal leukocyte tethering or rolling
  • impaired neutrophil chemotaxis
    • during experimental peritonitis   (MGI Ref ID J:75412)
  • increased eosinophil cell number
    • 3.5-fold higher than in wild-type mice   (MGI Ref ID J:75412)
  • increased neutrophil cell number
    • 2.9-fold higher than in wild-type mice   (MGI Ref ID J:75412)
  • hematopoietic system phenotype
  • abnormal leukocyte tethering or rolling
  • impaired neutrophil chemotaxis
    • during experimental peritonitis   (MGI Ref ID J:75412)
  • increased eosinophil cell number
    • 3.5-fold higher than in wild-type mice   (MGI Ref ID J:75412)
  • increased neutrophil cell number
    • 2.9-fold higher than in wild-type mice   (MGI Ref ID J:75412)
  • cellular phenotype
  • abnormal leukocyte tethering or rolling
  • impaired neutrophil chemotaxis
    • during experimental peritonitis   (MGI Ref ID J:75412)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Selplgtm1Fur related

Cell Biology Research
Defects in Cell Adhesion Molecules

Hematological Research
Clotting Defects
Hematopoietic Defects
Immunological Defects
      B and T cell deficiency
Platelet Defects
      Alterations in platelet aggregation

Immunology, Inflammation and Autoimmunity Research
Growth Factors/Receptors/Cytokines
Immunodeficiency
      T cell deficiency

Internal/Organ Research
Lymphoid Tissue Defects
Wound Healing

Research Tools
Hematological Research
Immunology, Inflammation and Autoimmunity Research

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Selplgtm1Fur
Allele Name targeted mutation 1, Bruce Furie
Allele Type Targeted (knock-out)
Common Name(s) PSGL-1-;
Mutation Made By Bruce Furie,   Harvard Med School/Beth Israel Deaconess
Strain of OriginSTOCK 129/Sv and C57BL/6J and SJL
ES Cell Line NameWW6
ES Cell Line StrainSTOCK 129/Sv and C57BL/6J and SJL
Gene Symbol and Name Selplg, selectin, platelet (p-selectin) ligand
Chromosome 5
Gene Common Name(s) CD162; CLA; PSGL-1; PSGL1; Selpl;
Molecular Note A neomycin resistance cassette replaced a small DNA segment of the coding region (+69 to 94). A 300 bp segment in the 5' flanking region containing CT repeats was also deleted. Northern blot analysis on thymus and spleen RNA from homozygous mice demonstrated that no detecable transcript was produced from this allele. Flow cytometry experiments on leukocytes derived from homozygous mice confirmed that no detectable cell surface protein was expressed from this allele. [MGI Ref ID J:75412]

Genotyping

Genotyping Information

Genotyping Protocols

Selplgtm1Fur, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Yang J; Hirata T; Croce K; Merrill-Skoloff G; Tchernychev B; Williams E; Flaumenhaft R; Furie BC; Furie B. 1999. Targeted gene disruption demonstrates that P-selectin glycoprotein ligand 1 (PSGL-1) is required for P-selectin-mediated but not E-selectin-mediated neutrophil rolling and migration. J Exp Med 190(12):1769-82. [PubMed: 10601352]  [MGI Ref ID J:75412]

Additional References

Selplgtm1Fur related

Alcaide P; King SL; Dimitroff CJ; Lim YC; Fuhlbrigge RC; Luscinskas FW. 2007. The 130-kDa glycoform of CD43 functions as an E-selectin ligand for activated Th1 cells in vitro and in delayed-type hypersensitivity reactions in vivo. J Invest Dermatol 127(8):1964-72. [PubMed: 17392823]  [MGI Ref ID J:141733]

Atarashi K; Hirata T; Matsumoto M; Kanemitsu N; Miyasaka M. 2005. Rolling of Th1 cells via P-selectin glycoprotein ligand-1 stimulates LFA-1-mediated cell binding to ICAM-1. J Immunol 174(3):1424-32. [PubMed: 15661900]  [MGI Ref ID J:96414]

Carlow DA; Ziltener HJ. 2006. CD43 deficiency has no impact in competitive in vivo assays of neutrophil or activated T cell recruitment efficiency. J Immunol 177(9):6450-9. [PubMed: 17056577]  [MGI Ref ID J:140506]

Chu YW; Schmitz S; Choudhury B; Telford W; Kapoor V; Garfield S; Howe D; Gress RE. 2008. Exogenous insulin-like growth factor 1 enhances thymopoiesis predominantly through thymic epithelial cell expansion. Blood 112(7):2836-46. [PubMed: 18658030]  [MGI Ref ID J:140225]

Dole VS; Bergmeier W; Mitchell HA; Eichenberger SC; Wagner DD. 2005. Activated platelets induce Weibel-Palade-body secretion and leukocyte rolling in vivo: role of P-selectin. Blood 106(7):2334-9. [PubMed: 15956287]  [MGI Ref ID J:119376]

Falati S; Liu Q; Gross P; Merrill-Skoloff G; Chou J; Vandendries E; Celi A; Croce K; Furie BC; Furie B. 2003. Accumulation of tissue factor into developing thrombi in vivo is dependent upon microparticle P-selectin glycoprotein ligand 1 and platelet P-selectin. J Exp Med 197(11):1585-98. [PubMed: 12782720]  [MGI Ref ID J:83734]

Gainers ME; Descheny L; Barthel SR; Liu L; Wurbel MA; Dimitroff CJ. 2007. Skin-homing receptors on effector leukocytes are differentially sensitive to glyco-metabolic antagonism in allergic contact dermatitis. J Immunol 179(12):8509-18. [PubMed: 18056398]  [MGI Ref ID J:155193]

Gossens K; Naus S; Corbel SY; Lin S; Rossi FM; Kast J; Ziltener HJ. 2009. Thymic progenitor homing and lymphocyte homeostasis are linked via S1P-controlled expression of thymic P-selectin/CCL25. J Exp Med 206(4):761-78. [PubMed: 19289576]  [MGI Ref ID J:147871]

Hara T; Shimizu K; Ogawa F; Yanaba K; Iwata Y; Muroi E; Takenaka M; Komura K; Hasegawa M; Fujimoto M; Sato S. 2010. Platelets control leukocyte recruitment in a murine model of cutaneous arthus reaction. Am J Pathol 176(1):259-69. [PubMed: 20008131]  [MGI Ref ID J:156487]

Harakawa N; Shigeta A; Wato M; Merrill-Skoloff G; Furie BC; Furie B; Okazaki T; Domae N; Miyasaka M; Hirata T. 2007. P-selectin glycoprotein ligand-1 mediates L-selectin-independent leukocyte rolling in high endothelial venules of peripheral lymph nodes. Int Immunol 19(3):321-9. [PubMed: 17267415]  [MGI Ref ID J:118672]

He X; Schoeb TR; Panoskaltsis-Mortari A; Zinn KR; Kesterson RA; Zhang J; Samuel S; Hicks MJ; Hickey MJ; Bullard DC. 2006. Deficiency of P-selectin or P-selectin glycoprotein ligand-1 leads to accelerated development of glomerulonephritis and increased expression of CC chemokine ligand 2 in lupus-prone mice. J Immunol 177(12):8748-56. [PubMed: 17142777]  [MGI Ref ID J:127199]

Hidalgo A; Chang J; Jang JE; Peired AJ; Chiang EY; Frenette PS. 2009. Heterotypic interactions enabled by polarized neutrophil microdomains mediate thromboinflammatory injury. Nat Med 15(4):384-91. [PubMed: 19305412]  [MGI Ref ID J:149370]

Hidalgo A; Peired AJ; Wild MK; Vestweber D; Frenette PS. 2007. Complete identification of E-selectin ligands on neutrophils reveals distinct functions of PSGL-1, ESL-1, and CD44. Immunity 26(4):477-89. [PubMed: 17442598]  [MGI Ref ID J:123577]

Hirata T; Furie BC; Furie B. 2002. P-, E-, and L-selectin mediate migration of activated CD8+ T lymphocytes into inflamed skin. J Immunol 169(8):4307-13. [PubMed: 12370362]  [MGI Ref ID J:107382]

Hirata T; Merrill-Skoloff G; Aab M; Yang J; Furie BC; Furie B. 2000. P-Selectin glycoprotein ligand 1 (PSGL-1) is a physiological ligand for E-selectin in mediating T helper 1 lymphocyte migration. J Exp Med 192(11):1669-76. [PubMed: 11104809]  [MGI Ref ID J:115108]

Kerfoot SM; Norman MU; Lapointe BM; Bonder CS; Zbytnuik L; Kubes P. 2006. Reevaluation of P-selectin and alpha 4 integrin as targets for the treatment of experimental autoimmune encephalomyelitis. J Immunol 176(10):6225-34. [PubMed: 16670333]  [MGI Ref ID J:131757]

Kidder D; Richards HE; Ziltener HJ; Garden OA; Crocker PR. 2013. Sialoadhesin Ligand Expression Identifies a Subset of CD4+Foxp3- T Cells with a Distinct Activation and Glycosylation Profile. J Immunol 190(6):2593-602. [PubMed: 23408841]  [MGI Ref ID J:193817]

Lam FW; Burns AR; Smith CW; Rumbaut RE. 2011. Platelets enhance neutrophil transendothelial migration via P-selectin glycoprotein ligand-1. Am J Physiol Heart Circ Physiol 300(2):H468-75. [PubMed: 21169400]  [MGI Ref ID J:169607]

Looney MR; Nguyen JX; Hu Y; Van Ziffle JA; Lowell CA; Matthay MA. 2009. Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury. J Clin Invest 119(11):3450-61. [PubMed: 19809160]  [MGI Ref ID J:154615]

Matsumoto M; Shigeta A; Furukawa Y; Tanaka T; Miyasaka M; Hirata T. 2007. CD43 collaborates with P-selectin glycoprotein ligand-1 to mediate E-selectin-dependent T cell migration into inflamed skin. J Immunol 178(4):2499-506. [PubMed: 17277158]  [MGI Ref ID J:147254]

Matsumoto M; Shigeta A; Miyasaka M; Hirata T. 2008. CD43 plays both antiadhesive and proadhesive roles in neutrophil rolling in a context-dependent manner. J Immunol 181(5):3628-35. [PubMed: 18714037]  [MGI Ref ID J:138936]

Merzaban JS; Zuccolo J; Corbel SY; Williams MJ; Ziltener HJ. 2005. An alternate core 2 beta1,6-N-acetylglucosaminyltransferase selectively contributes to P-selectin ligand formation in activated CD8 T cells. J Immunol 174(7):4051-9. [PubMed: 15778363]  [MGI Ref ID J:97929]

Nacher M; Blazquez AB; Shao B; Matesanz A; Prophete C; Berin MC; Frenette PS; Hidalgo A. 2011. Physiological Contribution of CD44 as a Ligand for E-Selectin during Inflammatory T-Cell Recruitment. Am J Pathol 178(5):2437-46. [PubMed: 21457936]  [MGI Ref ID J:171380]

Nakao S; Zandi S; Faez S; Kohno R; Hafezi-Moghadam A. 2012. Discontinuous LYVE-1 expression in corneal limbal lymphatics: dual function as microvalves and immunological hot spots. FASEB J 26(2):808-17. [PubMed: 22090317]  [MGI Ref ID J:180605]

Osmers I; Bullard DC; Barnum SR. 2005. PSGL-1 is not required for development of experimental autoimmune encephalomyelitis. J Neuroimmunol 166(1-2):193-6. [PubMed: 16005524]  [MGI Ref ID J:106363]

Ostanin DV; Furr KL; Pavlick KP; Gray L; Kevil CG; Shukla D; D'Souza D; Hoffman JM; Grisham MB. 2007. T cell-associated CD18 but not CD62L, ICAM-1, or PSGL-1 is required for the induction of chronic colitis. Am J Physiol Gastrointest Liver Physiol 292(6):G1706-14. [PubMed: 17332469]  [MGI Ref ID J:123696]

Rossi FM; Corbel SY; Merzaban JS; Carlow DA; Gossens K; Duenas J; So L; Yi L; Ziltener HJ. 2005. Recruitment of adult thymic progenitors is regulated by P-selectin and its ligand PSGL-1. Nat Immunol 6(6):626-34. [PubMed: 15880112]  [MGI Ref ID J:98951]

Sato C; Shikata K; Hirota D; Sasaki M; Nishishita S; Miyamoto S; Kodera R; Ogawa D; Tone A; Kataoka HU; Wada J; Kajitani N; Makino H. 2011. P-selectin glycoprotein ligand-1 deficiency is protective against obesity-related insulin resistance. Diabetes 60(1):189-99. [PubMed: 20971965]  [MGI Ref ID J:170158]

Shigeta A; Matsumoto M; Tedder TF; Lowe JB; Miyasaka M; Hirata T. 2008. An L-selectin ligand distinct from P-selectin glycoprotein ligand-1 is expressed on endothelial cells and promotes neutrophil rolling in inflammation. Blood 112(13):4915-23. [PubMed: 18818390]  [MGI Ref ID J:144251]

Sreeramkumar V; Leiva M; Stadtmann A; Pitaval C; Ortega-Rodriguez I; Wild MK; Lee B; Zarbock A; Hidalgo A. 2013. Coordinated and unique functions of the E-selectin ligand ESL-1 during inflammatory and hematopoietic recruitment in mice. Blood 122(24):3993-4001. [PubMed: 24106206]  [MGI Ref ID J:205144]

Urzainqui A; Martinez del Hoyo G; Lamana A; de la Fuente H; Barreiro O; Olazabal IM; Martin P; Wild MK; Vestweber D; Gonzalez-Amaro R; Sanchez-Madrid F. 2007. Functional role of P-selectin glycoprotein ligand 1/P-selectin interaction in the generation of tolerogenic dendritic cells. J Immunol 179(11):7457-65. [PubMed: 18025190]  [MGI Ref ID J:154814]

Veerman KM; Carlow DA; Shanina I; Priatel JJ; Horwitz MS; Ziltener HJ. 2012. PSGL-1 regulates the migration and proliferation of CD8(+) T cells under homeostatic conditions. J Immunol 188(4):1638-46. [PubMed: 22250093]  [MGI Ref ID J:181166]

Veerman KM; Williams MJ; Uchimura K; Singer MS; Merzaban JS; Naus S; Carlow DA; Owen P; Rivera-Nieves J; Rosen SD; Ziltener HJ. 2007. Interaction of the selectin ligand PSGL-1 with chemokines CCL21 and CCL19 facilitates efficient homing of T cells to secondary lymphoid organs. Nat Immunol 8(5):532-9. [PubMed: 17401367]  [MGI Ref ID J:122420]

Wang HB; Wang JT; Zhang L; Geng ZH; Xu WL; Xu T; Huo Y; Zhu X; Plow EF; Chen M; Geng JG. 2007. P-selectin primes leukocyte integrin activation during inflammation. Nat Immunol 8(8):882-892. [PubMed: 17632516]  [MGI Ref ID J:123408]

Yoshizaki A; Yanaba K; Iwata Y; Komura K; Ogawa A; Akiyama Y; Muroi E; Hara T; Ogawa F; Takenaka M; Shimizu K; Hasegawa M; Fujimoto M; Tedder TF; Sato S. 2010. Cell Adhesion Molecules Regulate Fibrotic Process via Th1/Th2/Th17 Cell Balance in a Bleomycin-Induced Scleroderma Model. J Immunol 185(4):2502-15. [PubMed: 20624949]  [MGI Ref ID J:162381]

Zlotoff DA; Zhang SL; De Obaldia ME; Hess PR; Todd SP; Logan TD; Bhandoola A. 2011. Delivery of progenitors to the thymus limits T-lineage reconstitution after bone marrow transplantation. Blood 118(7):1962-70. [PubMed: 21659540]  [MGI Ref ID J:176932]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryThis strain originated on a STOCK background, has been backcrossed for 5 generations on the C57BL/6J background before being made homozygous. Coat color expected from breeding:Black

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2450.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3185.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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