Strain Name:

NOD.129P2(B6)-Il4tm1Cgn/DvsJ

Stock Number:

004222

Availability:

Repository-Cryopreserved

Use Restrictions Apply, see Terms of Use

Description

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered Mutant Mice.
Specieslaboratory mouse
Background Strain NOD/ShiLt
Donor Strain 129P2
H2 Haplotypeg7
GenerationN9F16p
 
Donating Investigator David Serreze,   The Jackson Laboratory

Appearance
albino, pink eyed
Related Genotype: A/A Tyrc/Tyrc

Description
Complete Freund's adjuvant (CFA) induced suppression of diabetes in NOD mice has been associated with a shift to Th2 cytokine production. NOD mice deficient in IL4 were created to investigate the role of IL4 in this shift. Mice homozygous for the Il4tm1Cgn targeted mutation are viable and fertile. T and B cell development is normal but IgG1and IgE levels and the ability of homozygous mutant mice to produce Th2-derived cytokines are significantly reduced. IL4 deficient NOD mice develop IDDM with the same incidence as standard NOD/Lt controls, and there is no change between IL4 deficient and wildtype NOD in disease protection conferred by treatment of bacillus Calmette-Guerin vaccine (BCG) or CFA. Both IL4 deficient and wildtype NOD mice are significantly protected from insulitis by treatment of CFA but not by treatment of BCG. (Serreze et al 2001)

Development
A 4.5 kb targeting vector containing the first two exons of the Il4 gene and a neomycin resistance cassette was used to disrupt the first exon of Il4. This construct was transfected into E14-1 embryonic stem cells (derived from 129P2/OlaHsd). Correctly targeted ES cells were injected into C57BL/6 blastocysts. The mutation was maintained on a B6;129 segregating background until it was congenically transferred to NOD/Lt using a marker assisted protocol. At the sixth backcross generation, mice heterozygous for the Il4tm1Cgn mutation and homozygous for all insulin dependent diabetes susceptibility loci (Idd) were intercrossed to produce mice homozygous for the mutation and all Idds. This strain is maintained by sibling mating homozygotes. (Kuhn et al., 1991; Serreze et al., 2001.)

Control Information

  Control
   001976 NOD/ShiLtJ
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Il4tm1Cgn allele
002253   B6.129P2-Il4tm1Cgn/J
005879   D1Lac.Cg-Il4tm1Cgn/J
002574   NOD.129P2(B6)-Il4tm1Cgn/Dvs
004228   NOD.Cg-Il10tm1Cgn Il4tm1Cgn/Dvs
004291   NOD.Cg-Il10tm1Cgn Il4tm1Cgn/DvsJ
View Strains carrying   Il4tm1Cgn     (5 strains)

Strains carrying other alleles of Il4
002496   BALB/c-Il4tm2Nnt/J
004190   C.129-Il4tm1Lky/J
003480   C.129S2(B6)-Il4tm1Gru/J
002518   C57BL/6-Il4tm1Nnt/J
002230   C57BL/6J-Tg(LckIl4)1315Dbl/J
006698   NOD.Cg-Il4tm1Lky/JbsJ
View Strains carrying other alleles of Il4     (6 strains)

Additional Web Information

Congenic Nomenclature

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms
Diabetes Mellitus, Insulin-Dependent; IDDM - Models with phenotypic similarity to human disease where etiologies are distinct.2
Sjogren Syndrome - 5
2 Human genes are associated with this disease. Orthologs of those genes do not appear in the mouse genotype(s).
5 Conditionally targeted allele(s)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms
      assigned by genotype

Il4tm1Cgn/Il4tm1Cgn

        NOD.129P2-Il4tm1Cgn
  • homeostasis/metabolism phenotype
  • abnormal enzyme/coenzyme activity (MGI Ref ID J:105803)
    • amylase activity increases slightly between 4 and 20 weeks of age (234 to 291 U/L) compared to activity in wild-type which declines
    • parotid secretory protein protease activity is retained in mutants while non-diseased BALB/c animals do not show activity
  • increased circulating glucose level (MGI Ref ID J:95105)
    • mice are diabetic if 2 consecutive measures of blood glucose are >240 mg/dl
  • endocrine/exocrine gland phenotype
  • abnormal salivary gland physiology (MGI Ref ID J:105803)
    • mice do not exhibit a decrease in salivary flow rates compared to NOD.B10-H2b mice at 4 weeks of age
    • saliva maintains normal protein concentrations compared to NOD and NOD.B10-H2b controls
  • immune system phenotype
  • decreased susceptibility to autoimmune disorder (MGI Ref ID J:95105)
    • in null females challenged with coxsackievirus B4 at 8 weeks of age, diabetes onset is not accelerated as it is in wild-type NOD females; over the 25-week follow up period, only 23% of CVB4 exposed nulls develop diabetes compared to 63% of saline-treated controls
  • increased susceptibility to autoimmune disorder (MGI Ref ID J:95105)
    • at 12 weeks of age, null females challenged with CVB4 develop diabetes at an accelerated rate compared with saline-treated controls (80% at 10 days after infection versus 30% of controls)
  • digestive/alimentary phenotype
  • abnormal salivary gland physiology (MGI Ref ID J:105803)
    • mice do not exhibit a decrease in salivary flow rates compared to NOD.B10-H2b mice at 4 weeks of age
    • saliva maintains normal protein concentrations compared to NOD and NOD.B10-H2b controls

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Il4tm1Cgn/Il4tm1Cgn

        NOD.Cg-H2b Il4tm1Cgn
  • homeostasis/metabolism phenotype
  • abnormal enzyme/coenzyme activity (MGI Ref ID J:105803)
    • amylase activity increases slightly between 4 and 20 weeks of age(181 to 250 U/L) compared to activity in wild-type which decreases (386 to 288 U/L)
    • parotid secretory protein protease activity is retained in mutants while non-diseased animals do not show activity
  • endocrine/exocrine gland phenotype
  • abnormal salivary gland physiology (MGI Ref ID J:105803)
    • mice do not exhibit a decrease in salivary flow rates compared to NOD.B10-H2b mice at 4 weeks of age; normal salivary flow is retained to 36 weeks of age compared to controls
    • saliva maintains normal protein concentrations compared to NOD and NOD.B10-H2b controls
    • salivary gland inflammation (MGI Ref ID J:105803)
      • foci of leukocytic infiltration contain more T cells than NOD.B10-H2b controls
  • immune system phenotype
  • lacrimal gland inflammation (MGI Ref ID J:105803)
    • foci of leukocytic infiltration contain more T cells than NOD.B10-H2b controls
  • salivary gland inflammation (MGI Ref ID J:105803)
    • foci of leukocytic infiltration contain more T cells than NOD.B10-H2b controls
  • vision/eye phenotype
  • lacrimal gland inflammation (MGI Ref ID J:105803)
    • foci of leukocytic infiltration contain more T cells than NOD.B10-H2b controls
  • digestive/alimentary phenotype
  • abnormal salivary gland physiology (MGI Ref ID J:105803)
    • mice do not exhibit a decrease in salivary flow rates compared to NOD.B10-H2b mice at 4 weeks of age; normal salivary flow is retained to 36 weeks of age compared to controls
    • saliva maintains normal protein concentrations compared to NOD and NOD.B10-H2b controls
    • salivary gland inflammation (MGI Ref ID J:105803)
      • foci of leukocytic infiltration contain more T cells than NOD.B10-H2b controls

Il4tm1Cgn/Il4tm1Cgn

        involves: 129P2/OlaHsd * NOD
  • immune system phenotype
  • abnormal cytokine secretion (MGI Ref ID J:85924)
    • CD4+ T cells from deficient animals show a strongly reduced ability to produce Il5 after anti-TCR stimulation compared to wild-type cells
  • decreased IgG1 level (MGI Ref ID J:85924)
    • CD4+ T cells from deficient animals show a reduction in circulating IgG1 in the absence of deliberate immunization

Il4tm1Cgn/Il4tm1Cgn

        either: NOD.129-Il4tm1Cgn or (involves: 129 * NOD)
  • endocrine/exocrine gland phenotype
  • insulitis (MGI Ref ID J:85924)
    • at 12 weeks, insulitis incidence is similar in homozygous mutants and heterozygous controls on the NOD background (N4)
  • immune system phenotype
  • autoimmune response (MGI Ref ID J:85924)
    • there is no difference in timing or penetrance of diabetes in IL4-deficient NOD mice (N8) compared to heterozygous or wild-type NOD mice
  • insulitis (MGI Ref ID J:85924)
    • at 12 weeks, insulitis incidence is similar in homozygous mutants and heterozygous controls on the NOD background (N4)
  • digestive/alimentary phenotype
  • insulitis (MGI Ref ID J:85924)
    • at 12 weeks, insulitis incidence is similar in homozygous mutants and heterozygous controls on the NOD background (N4)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Diabetes and Obesity Research
Impaired Wound Healing
Islet Transplantation Studies
Type 1 Diabetes (IDDM) (Congenics with mutations affecting cytokine production by autoreactive T cells)
Type 1 Diabetes (IDDM) Analysis Strains (NOD Congenics with Mutations Affecting Cytokine Production by Autoreactive T Cells)
Type 1 Diabetes (IDDM) Analysis Strains (NOD Congenics with Mutations Affecting Immunocompetence)

Hematological Research
Immunological Defects

Immunology and Inflammation Research
Immunodeficiency (specific T cell deficiency)
Immunodeficiency Associated with Other Defects
Inflammation
Lymphoid Tissue Defects
Vaccine Development

Internal/Organ Research
Wound Healing

Research Tools
Cancer Research (T cell deficiency)
Cancer Research (xenograft/transplant host)
Immunology and Inflammation Research (genes regulating susceptibility to infectious disease and endotoxin)
Immunology and Inflammation Research (production of T cell lines and hybridomas)
Immunology and Inflammation Research (specific T cell deficiency)
Internal/Organ Research
Toxicology Research (B and T cell deficiency) (xenograft transplant host)

Il4tm1Cgn related

Cancer Research
Growth Factors/Receptors/Cytokines

Immunology and Inflammation Research
Growth Factors/Receptors/Cytokines

Genes & Alleles

Gene & Allele Information

Allele Symbol Il4tm1Cgn
Allele Name targeted mutation 1, University of Cologne
Allele Type Targeted (knock-out)
Common Name(s) IL-4 KO; IL-4-; IL-4KO; IL-4T-; IL4-; IL4tm1cgn129; IL4T;
Mutation Made By Ralf Kuhn,   University of Cologne
Strain of Origin129P2/OlaHsd
ES Cell Line NameE14.1
ES Cell Line Strain129P2/OlaHsd
Gene Symbol and Name Il4, interleukin 4
Chromosome 11
Gene Common Name(s) BCGF-1; BCGF1; BSF1; IL-4; Il-4; Il4e12; MGC79402;
Molecular Note A translational stop codon and a neomycin resistance gene were inserted into the first exon of the gene. [MGI Ref ID J:704]

Genotyping

Genotyping Information

Genotyping Protocols

Il4tm1Cgn, STD PCR, vers. 1

Helpful Links

Optimizing PCR Protocols

References

References

Selected Reference(s)

Serreze DV; Chapman HD; Post CM; Johnson EA; Suarez-Pinzon WL; Rabinovitch A. 2001. Th1 to Th2 cytokine shifts in nonobese diabetic mice: sometimes an outcome, rather than the cause, of diabetes resistance elicited by immunostimulation. J Immunol 166(2):1352-9. [PubMed: 11145720]  [MGI Ref ID J:109883]

Additional References

Dohi T; Fujihashi K; Kiyono H; Elson CO; McGhee JR. 2000. Mice deficient in Th1- and Th2-type cytokines develop distinct forms of hapten-induced colitis. Gastroenterology 119(3):724-33. [PubMed: 10982767]  [MGI Ref ID J:64230]

Hadeiba H; Corry DB; Locksley RM. 2000. Baseline airway hyperreactivity in A/J mice is not mediated by cells of the adaptive immune system. J Immunol 164(9):4933-40. [PubMed: 10779804]  [MGI Ref ID J:61706]

Kuhn R; Rajewsky K; Muller W. 1991. Generation and analysis of interleukin-4 deficient mice. Science 254(5032):707-10. [PubMed: 1948049]  [MGI Ref ID J:704]

Metwali A; Blum AM; Li J; Elliott DE; Weinstock JV. 2000. IL-4 regulates VIP receptor subtype 2 mRNA (VPAC2) expression in T cells in murine schistosomiasis. FASEB J 14(7):948-54. [PubMed: 10783149]  [MGI Ref ID J:61805]

Tan JT; Dudl E; LeRoy E; Murray R; Sprent J; Weinberg KI; Surh CD. 2001. IL-7 is critical for homeostatic proliferation and survival of naive T cells. Proc Natl Acad Sci U S A 98(15):8732-7. [PubMed: 11447288]  [MGI Ref ID J:93058]

Il4tm1Cgn related

Aguirre SA; Perryman LE; Davis WC; McGuire TC. 1998. IL-4 protects adult C57BL/6 mice from prolonged Cryptosporidium parvum infection: analysis of CD4+alpha beta+IFN-gamma+ and CD4+alpha beta+IL-4+ lymphocytes in gut-associated lymphoid tissue during resolution of infection. J Immunol 161(4):1891-900. [PubMed: 9712058]  [MGI Ref ID J:49699]

Alard P; Clark SL; Kosiewicz MM. 2004. Mechanisms of tolerance induced by TGF beta-treated APC: CD4 regulatory T cells prevent the induction of the immune response possibly through a mechanism involving TGF beta. Eur J Immunol 34(4):1021-30. [PubMed: 15048712]  [MGI Ref ID J:115475]

Andersen C; Jensen T; Nansen A; Marker O; Thomsen AR. 1999. CD4(+) T cell-mediated protection against a lethal outcome of systemic infection with vesicular stomatitis virus requires CD40 ligand expression, but not IFN-gamma or IL-4. Int Immunol 11(12):2035-42. [PubMed: 10590269]  [MGI Ref ID J:110491]

Anderson AC; Reddy J; Nazareno R; Sobel RA; Nicholson LB; Kuchroo VK. 2004. IL-10 plays an important role in the homeostatic regulation of the autoreactive repertoire in naive mice. J Immunol 173(2):828-34. [PubMed: 15240669]  [MGI Ref ID J:91913]

Bachmann MF; Schorle H; Kuhn R; Muller W; Hengartner H; Zinkernagel RM; Horak I. 1995. Antiviral immune responses in mice deficient for both interleukin-2 and interleukin-4. J Virol 69(8):4842-6. [PubMed: 7609051]  [MGI Ref ID J:26861]

Bagley J; Sawada T; Wu Y; Iacomini J. 2000. A critical role for interleukin 4 in activating alloreactive CD4 T cells. Nat Immunol 1(3):257-61. [PubMed: 10973285]  [MGI Ref ID J:118019]

Bancroft AJ; Artis D; Donaldson DD; Sypek JP; Grencis RK. 2000. Gastrointestinal nematode expulsion in IL-4 knockout mice is IL-13 dependent. Eur J Immunol 30(7):2083-91. [PubMed: 10940898]  [MGI Ref ID J:63513]

Bancroft AJ; McKenzie AN; Grencis RK. 1998. A critical role for IL-13 in resistance to intestinal nematode infection. J Immunol 160(7):3453-61. [PubMed: 9531306]  [MGI Ref ID J:111618]

Beenhouwer DO; Shapiro S; Feldmesser M; Casadevall A; Scharff MD. 2001. Both Th1 and Th2 Cytokines Affect the Ability of Monoclonal Antibodies To Protect Mice against Cryptococcus neoformans. Infect Immun 69(10):6445-55. [PubMed: 11553589]  [MGI Ref ID J:71570]

Belghith M; Bluestone JA; Barriot S; Megret J; Bach JF; Chatenoud L. 2003. TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes. Nat Med 9(9):1202-8. [PubMed: 12937416]  [MGI Ref ID J:85362]

Belkaid Y; Hoffmann KF; Mendez S; Kamhawi S; Udey MC; Wynn TA; Sacks DL. 2001. The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure. J Exp Med 194(10):1497-506. [PubMed: 11714756]  [MGI Ref ID J:118003]

Berg DJ; Leach MW; Kuhn R; Rajewsky K; Muller W; Davidson NJ; Rennick D. 1995. Interleukin 10 but not interleukin 4 is a natural suppressant of cutaneous inflammatory responses. J Exp Med 182(1):99-108. [PubMed: 7790826]  [MGI Ref ID J:26221]

Bettelli E; Das MP; Howard ED; Weiner HL; Sobel RA; Kuchroo VK. 1998. IL-10 is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10- and IL-4-deficient and transgenic mice. J Immunol 161(7):3299-306. [PubMed: 9759845]  [MGI Ref ID J:115204]

Bezbradica JS; Gordy LE; Stanic AK; Dragovic S; Hill T; Hawiger J; Unutmaz D; Van Kaer L; Joyce S. 2006. Granulocyte-macrophage colony-stimulating factor regulates effector differentiation of invariant natural killer T cells during thymic ontogeny. Immunity 25(3):487-97. [PubMed: 16949316]  [MGI Ref ID J:113451]

Blackstock R; Murphy JW. 2004. Role of interleukin-4 in resistance to Cryptococcus neoformans infection. Am J Respir Cell Mol Biol 30(1):109-17. [PubMed: 12855407]  [MGI Ref ID J:95350]

Bour-Jordan H; Thompson HL; Bluestone JA. 2005. Distinct effector mechanisms in the development of autoimmune neuropathy versus diabetes in nonobese diabetic mice. J Immunol 175(9):5649-55. [PubMed: 16237054]  [MGI Ref ID J:119359]

Brayer JB; Cha S; Nagashima H; Yasunari U; Lindberg A; Diggs S; Martinez J; Goa J; Humphreys-Beher MG; Peck AB. 2001. IL-4-dependent effector phase in autoimmune exocrinopathy as defined by the NOD.IL-4-gene knockout mouse model of Sjogren's syndrome. Scand J Immunol 54(1-2):133-40. [PubMed: 11439159]  [MGI Ref ID J:103875]

Cain JA; Smith JA; Ondr JK; Wang B; Katz JD. 2006. NKT cells and IFN-gamma establish the regulatory environment for the control of diabetogenic T cells in the nonobese diabetic mouse. J Immunol 176(3):1645-54. [PubMed: 16424194]  [MGI Ref ID J:126603]

Chiaramonte MG; Mentink-Kane M; Jacobson BA; Cheever AW; Whitters MJ; Goad ME; Wong A; Collins M; Donaldson DD; Grusby MJ; Wynn TA. 2003. Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response. J Exp Med 197(6):687-701. [PubMed: 12642601]  [MGI Ref ID J:124413]

Cole N; Hume EB; Khan S; Garthwaite L; Schubert T; Reeve V; Willcox MD. 2007. The corneal response to infection with Staphylococcus aureus in the absence of interleukin-4. Immunol Cell Biol 85(4):333-7. [PubMed: 17389870]  [MGI Ref ID J:122715]

Cunningham AF; Fallon PG; Khan M; Vacheron S; Acha-Orbea H; MacLennan IC; McKenzie AN; Toellner KM. 2002. Th2 activities induced during virgin T cell priming in the absence of IL-4, IL-13, and B cells. J Immunol 169(6):2900-6. [PubMed: 12218103]  [MGI Ref ID J:120432]

D'Orazio TJ; Niederkorn JY. 1998. A novel role for TGF-beta and IL-10 in the induction of immune privilege. J Immunol 160(5):2089-98. [PubMed: 9498745]  [MGI Ref ID J:111362]

Denzel A; Maus UA; Rodriguez Gomez M; Moll C; Niedermeier M; Winter C; Maus R; Hollingshead S; Briles DE; Kunz-Schughart LA; Talke Y; Mack M. 2008. Basophils enhance immunological memory responses. Nat Immunol 9(7):733-42. [PubMed: 18516038]  [MGI Ref ID J:137679]

Diaz-de-Durana Y; Mantchev GT; Bram RJ; Franco A. 2006. TACI-BLyS signaling via B-cell-dendritic cell cooperation is required for naive CD8+ T-cell priming in vivo. Blood 107(2):594-601. [PubMed: 16195331]  [MGI Ref ID J:126637]

Dieli F; Sireci G; Scire E; Salerno A; Bellavia A. 1999. Impaired contact hypersensitivity to trinitrochlorobenzene in interleukin-4-deficient mice. Immunology 98(1):71-9. [PubMed: 10469236]  [MGI Ref ID J:110461]

Dohi T; Fujihashi K; Koga T; Etani Y; Yoshino N; Kawamura YI; McGhee JR. 2004. CD4+CD45RBHi interleukin-4 defective T cells elicit antral gastritis and duodenitis. Am J Pathol 165(4):1257-68. [PubMed: 15466391]  [MGI Ref ID J:93676]

Emson CL; Bell SE; Jones A; Wisden W; McKenzie AN. 1998. Interleukin (IL)-4-independent induction of immunoglobulin (Ig)E, and perturbation of T cell development in transgenic mice expressing IL-13. J Exp Med 188(2):399-404. [PubMed: 9670052]  [MGI Ref ID J:112473]

Everest P; Allen J; Papakonstantinopoulou A; Mastroeni P; Roberts M ; Dougan G. 1997. Salmonella typhimurium infections in mice deficient in interleukin-4 production: role of IL-4 in infection-associated pathology. J Immunol 159(4):1820-7. [PubMed: 9257845]  [MGI Ref ID J:42104]

Fallon PG; Ballantyne SJ; Mangan NE; Barlow JL; Dasvarma A; Hewett DR; McIlgorm A; Jolin HE; McKenzie AN. 2006. Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion. J Exp Med 203(4):1105-16. [PubMed: 16606668]  [MGI Ref ID J:123748]

Fallon PG; Emson CL; Smith P; McKenzie AN. 2001. IL-13 overexpression predisposes to anaphylaxis following antigen sensitization. J Immunol 166(4):2712-6. [PubMed: 11160336]  [MGI Ref ID J:135014]

Fallon PG; Jolin HE; Smith P; Emson CL; Townsend MJ; Fallon R; Smith P; McKenzie AN. 2002. IL-4 induces characteristic Th2 responses even in the combined absence of IL-5, IL-9, and IL-13. Immunity 17(1):7-17. [PubMed: 12150887]  [MGI Ref ID J:113543]

French AR; Sjolin H; Kim S; Koka R; Yang L; Young DA; Cerboni C; Tomasello E; Ma A; Vivier E; Karre K; Yokoyama WM. 2006. DAP12 signaling directly augments proproliferative cytokine stimulation of NK cells during viral infections. J Immunol 177(8):4981-90. [PubMed: 17015680]  [MGI Ref ID J:139300]

Gao J; Killedar S; Cornelius JG; Nguyen C; Cha S; Peck AB. 2006. Sjogren's syndrome in the NOD mouse model is an interleukin-4 time-dependent, antibody isotype-specific autoimmune disease. J Autoimmun 26(2):90-103. [PubMed: 16413168]  [MGI Ref ID J:105803]

Gonzalez A; Andre-Schmutz I; Carnaud C; Mathis D; Benoist C. 2001. Damage control, rather than unresponsiveness, effected by protective DX5+ T cells in autoimmune diabetes. Nat Immunol 2(12):1117-25. [PubMed: 11713466]  [MGI Ref ID J:109860]

Grunewald SM; Werthmann A; Schnarr B; Klein CE; Brocker EB; Mohrs M ; Brombacher F ; Sebald W ; Duschl A. 1998. An antagonistic IL-4 mutant prevents type I allergy in the mouse: inhibition of the IL-4/IL-13 receptor system completely abrogates humoral immune response to allergen and development of allergic symptoms in vivo. J Immunol 160(8):4004-9. [PubMed: 9558109]  [MGI Ref ID J:47244]

Harris DP; Goodrich S; Mohrs K; Mohrs M; Lund FE. 2005. Cutting edge: the development of IL-4-producing B cells (B effector 2 cells) is controlled by IL-4, IL-4 receptor alpha, and Th2 cells. J Immunol 175(11):7103-7. [PubMed: 16301612]  [MGI Ref ID J:122200]

Havarinasab S; Haggqvist B; Bjorn E; Pollard KM; Hultman P. 2005. Immunosuppressive and autoimmune effects of thimerosal in mice. Toxicol Appl Pharmacol 204(2):109-21. [PubMed: 15808517]  [MGI Ref ID J:97345]

Hertz CJ; Filutowicz H; Mansfield JM. 1998. Resistance to the African trypanosomes is IFN-gamma dependent. J Immunol 161(12):6775-83. [PubMed: 9862708]  [MGI Ref ID J:115095]

Hesse M; Modolell M; La Flamme AC; Schito M; Fuentes JM; Cheever AW; Pearce EJ; Wynn TA. 2001. Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of L-arginine metabolism. J Immunol 167(11):6533-44. [PubMed: 11714822]  [MGI Ref ID J:72822]

Hill NJ; Stotland AB; Sarvetnick NE. 2007. Distinct regulation of autoreactive CD4 T cell expansion by interleukin-4 under conditions of lymphopenia. J Leukoc Biol 81(3):757-65. [PubMed: 17164429]  [MGI Ref ID J:118599]

Hoffmann KF; Cheever AW; Wynn TA. 2000. IL-10 and the dangers of immune polarization: excessive type 1 and type 2 cytokine responses induce distinct forms of lethal immunopathology in murine schistosomiasis. J Immunol 164(12):6406-16. [PubMed: 10843696]  [MGI Ref ID J:124519]

Hoffmann KF; James SL; Cheever AW; Wynn TA. 1999. Studies with double cytokine-deficient mice reveal that highly polarized Th1- and Th2-type cytokine and antibody responses contribute equally to vaccine-induced immunity to Schistosoma mansoni. J Immunol 163(2):927-38. [PubMed: 10395689]  [MGI Ref ID J:56157]

Hofstetter HH; Sewell DL; Liu F; Sandor M; Forsthuber T; Lehmann PV; Fabry Z. 2003. Autoreactive T cells promote post-traumatic healing in the central nervous system. J Neuroimmunol 134(1-2):25-34. [PubMed: 12507769]  [MGI Ref ID J:119263]

Horsley V; Jansen KM; Mills ST; Pavlath GK. 2003. IL-4 acts as a myoblast recruitment factor during mammalian muscle growth. Cell 113(4):483-94. [PubMed: 12757709]  [MGI Ref ID J:107688]

Huaux F; Liu T; McGarry B; Ullenbruch M; Phan SH. 2003. Dual roles of IL-4 in lung injury and fibrosis. J Immunol 170(4):2083-92. [PubMed: 12574379]  [MGI Ref ID J:126708]

Hung K; Hayashi R; Lafond-Walker A; Lowenstein C; Pardoll D; Levitsky H. 1998. The central role of CD4(+) T cells in the antitumor immune response. J Exp Med 188(12):2357-68. [PubMed: 9858522]  [MGI Ref ID J:51677]

Inoue Y; Konieczny BT; Wagener ME; McKenzie AN; Lakkis FG. 2001. Failure to induce neonatal tolerance in mice that lack both IL-4 and IL-13 but not in those that lack IL-4 alone. J Immunol 167(2):1125-8. [PubMed: 11441125]  [MGI Ref ID J:106687]

Izbicki G; Or R; Christensen TG; Segel MJ; Fine A; Goldstein RH; Breuer R. 2002. Bleomycin-induced lung fibrosis in IL-4-overexpressing and knockout mice. Am J Physiol Lung Cell Mol Physiol 283(5):L1110-6. [PubMed: 12376365]  [MGI Ref ID J:107354]

Jabs DA; Prendergast RA; Campbell AL; Lee B; Akpek EK; Gerard HC; Hudson AP; Whittum-Hudson JA. 2007. Autoimmune Th2-mediated dacryoadenitis in MRL/MpJ mice becomes Th1-mediated in IL-4 deficient MRL/MpJ mice. Invest Ophthalmol Vis Sci 48(12):5624-9. [PubMed: 18055812]  [MGI Ref ID J:132514]

Keogh B; Atkins GJ; Mills KH; Sheahan BJ. 2002. Avirulent Semliki Forest virus replication and pathology in the central nervous system is enhanced in IL-12-defective and reduced in IL-4-defective mice: a role for Th1 cells in the protective immunity. J Neuroimmunol 125(1-2):15-22. [PubMed: 11960636]  [MGI Ref ID J:102960]

Ketavarapu JM; Rodriguez AR; Yu JJ; Cong Y; Murthy AK; Forsthuber TG; Guentzel MN; Klose KE; Berton MT; Arulanandam BP. 2008. Mast cells inhibit intramacrophage Francisella tularensis replication via contact and secreted products including IL-4. Proc Natl Acad Sci U S A 105(27):9313-8. [PubMed: 18591675]  [MGI Ref ID J:138191]

Kiani A; Garcia-Cozar FJ; Habermann I; Laforsch S; Aebischer T; Ehninger G; Rao A. 2001. Regulation of interferon-gamma gene expression by nuclear factor of activated T cells. Blood 98(5):1480-8. [PubMed: 11520798]  [MGI Ref ID J:115625]

Kim HY; Kim HJ; Min HS; Kim S; Park WS; Park SH; Chung DH. 2005. NKT cells promote antibody-induced joint inflammation by suppressing transforming growth factor beta1 production. J Exp Med 201(1):41-7. [PubMed: 15630137]  [MGI Ref ID J:95287]

Kim JH; Kim HY; Kim S; Chung JH; Park WS; Chung DH. 2005. Natural Killer T (NKT) Cells Attenuate Bleomycin-Induced Pulmonary Fibrosis by Producing Interferon-{gamma}. Am J Pathol 167(5):1231-41. [PubMed: 16251408]  [MGI Ref ID J:102402]

King VL; Cassis LA; Daugherty A. 2007. Interleukin-4 does not influence development of hypercholesterolemia or angiotensin II-induced atherosclerotic lesions in mice. Am J Pathol 171(6):2040-7. [PubMed: 18055554]  [MGI Ref ID J:128948]

King VL; Szilvassy SJ; Daugherty A. 2002. Interleukin-4 deficiency decreases atherosclerotic lesion formation in a site-specific manner in female LDL receptor-/- mice. Arterioscler Thromb Vasc Biol 22(3):456-61. [PubMed: 11884290]  [MGI Ref ID J:103308]

King VL; Szilvassy SJ; Daugherty A. 2002. Interleukin-4 deficiency promotes gallstone formation. J Lipid Res 43(5):768-71. [PubMed: 11971948]  [MGI Ref ID J:76258]

Kono DH; Balomenos D; Park MS; Theofilopoulos AN. 2000. Development of lupus in BXSB mice is independent of IL-4. J Immunol 164(1):38-42. [PubMed: 10604990]  [MGI Ref ID J:112421]

Kono DH; Balomenos D; Pearson DL; Park MS; Hildebrandt B; Hultman P; Pollard KM. 1998. The prototypic Th2 autoimmunity induced by mercury is dependent on IFN-gamma and not Th1/Th2 imbalance. J Immunol 161(1):234-40. [PubMed: 9647229]  [MGI Ref ID J:119207]

Kosiewicz MM; Alard P; Liang S; Clark SL. 2004. Mechanisms of tolerance induced by transforming growth factor-beta-treated antigen-presenting cells: CD8 regulatory T cells inhibit the effector phase of the immune response in primed mice through a mechanism involving Fas ligand. Int Immunol 16(5):697-706. [PubMed: 15096489]  [MGI Ref ID J:89454]

Kosiewicz MM; Alard P; Streilein JW. 1998. Alterations in cytokine production following intraocular injection of soluble protein antigen: impairment in IFN-gamma and induction of TGF-beta and IL-4 production. J Immunol 161(10):5382-90. [PubMed: 9820512]  [MGI Ref ID J:115024]

Kuhn R; Rajewsky K; Muller W. 1991. Generation and analysis of interleukin-4 deficient mice. Science 254(5032):707-10. [PubMed: 1948049]  [MGI Ref ID J:704]

Kurup VP; Choi HY; Murali PS; Xia JQ; Coffman RL; Fink JN. 1999. Immune responses to Aspergillus antigen in IL-4-/-mice and the effect of eosinophil ablation. Allergy 54(5):420-7. [PubMed: 10380772]  [MGI Ref ID J:103304]

Kurup VP; Xia JQ; Rickaby DA; Dawson CA; Choi H; Fink JN. 1999. Aspergillus fumigatus antigen exposure results in pulmonary airway resistance in wild-type but not in IL-4 knockout mice. Clin Immunol 90(3):404-10. [PubMed: 10075870]  [MGI Ref ID J:114248]

Lambrecht BN; De Veerman M; Coyle AJ; Gutierrez-Ramos JC; Thielemans K; Pauwels RA. 2000. Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation. J Clin Invest 106(4):551-9. [PubMed: 10953030]  [MGI Ref ID J:115351]

Lange C; Schuler T; Blankenstein T. 1998. Interleukin 4 gene-defective mice reconstituted with wild-type bone marrow fail to produce normal immunoglobulin E levels. J Exp Med 187(9):1487-93. [PubMed: 9565640]  [MGI Ref ID J:47468]

Li XC; Roy-Chaudhury P; Hancock WW; Manfro R; Zand MS; Li Y; Zheng XX; Nickerson PW; Steiger J; Malek TR; Strom TB. 1998. IL-2 and IL-4 double knockout mice reject islet allografts: a role for novel T cell growth factors in allograft rejection. J Immunol 161(2):890-6. [PubMed: 9670967]  [MGI Ref ID J:48547]

Liblau R; Steinman L; Brocke S. 1997. Experimental autoimmune encephalomyelitis in IL-4-deficient mice. Int Immunol 9(5):799-803. [PubMed: 9184926]  [MGI Ref ID J:40957]

MacDonald AS; Loke P; Allen JE. 1999. Suppressive antigen-presenting cells in Helminth infection. Pathobiology 67(5-6):265-8. [PubMed: 10725799]  [MGI Ref ID J:61096]

MacDonald AS; Pearce EJ. 2002. Cutting edge: polarized Th cell response induction by transferred antigen-pulsed dendritic cells is dependent on IL-4 or IL-12 production by recipient cells. J Immunol 168(7):3127-30. [PubMed: 11907061]  [MGI Ref ID J:126393]

Mahon BP; Sheahan BJ; Griffin F; Murphy G; Mills KH. 1997. Atypical disease after Bordetella pertussis respiratory infection of mice with targeted disruptions of interferon-gamma receptor or immunoglobulin mu chain genes. J Exp Med 186(11):1843-51. [PubMed: 9382883]  [MGI Ref ID J:44402]

Matheson JM; Johnson VJ; Luster MI. 2005. Immune mediators in a murine model for occupational asthma: studies with toluene diisocyanate. Toxicol Sci 84(1):99-109. [PubMed: 15590890]  [MGI Ref ID J:106452]

Matthews DJ; Emson CL; McKenzie GJ; Jolin HE; Blackwell JM; McKenzie AN. 2000. IL-13 is a susceptibility factor for Leishmania major infection. J Immunol 164(3):1458-62. [PubMed: 10640762]  [MGI Ref ID J:127057]

McGuirk P; Mills KH. 2000. A regulatory role for interleukin 4 in differential inflammatory responses in the lung following infection of mice primed with Th1- or Th2-inducing pertussis vaccines. Infect Immun 68(3):1383-90. [PubMed: 10678951]  [MGI Ref ID J:60572]

McKenzie GJ; Fallon PG; Emson CL; Grencis RK; McKenzie AN. 1999. Simultaneous disruption of interleukin (IL)-4 and IL-13 defines individual roles in T helper cell type 2-mediated responses. J Exp Med 189(10):1565-72. [PubMed: 10330435]  [MGI Ref ID J:89095]

Metwali A; Blum AM; Li J; Elliott DE; Weinstock JV. 2000. IL-4 regulates VIP receptor subtype 2 mRNA (VPAC2) expression in T cells in murine schistosomiasis. FASEB J 14(7):948-54. [PubMed: 10783149]  [MGI Ref ID J:61805]

Mizoguchi A; Mizoguchi E; Bhan AK. 1999. The critical role of interleukin 4 but not interferon gamma in the pathogenesis of colitis in T-cell receptor alpha mutant mice. Gastroenterology 116(2):320-6. [PubMed: 9922312]  [MGI Ref ID J:92347]

Mizoguchi A; Mizoguchi E; Saubermann LJ; Higaki K; Blumberg RS; Bhan AK. 2000. Limited CD4 T-cell diversity associated with colitis in T-cell receptor alpha mutant mice requires a T helper 2 environment Gastroenterology 119(4):983-95. [PubMed: 11040185]  [MGI Ref ID J:65143]

Mizoguchi A; Ogawa A; Takedatsu H; Sugimoto K; Shimomura Y; Shirane K; Nagahama K; Nagaishi T; Mizoguchi E; Blumberg RS; Bhan AK. 2007. Dependence of intestinal granuloma formation on unique myeloid DC-like cells. J Clin Invest 117(3):605-15. [PubMed: 17318261]  [MGI Ref ID J:120740]

Morawetz RA; Doherty TM; Giese NA; Hartley JW; Muller W; Kuhn R; Rajewsky K; Coffman R; Morse HC 3rd. 1994. Resistance to murine acquired immunodeficiency syndrome (MAIDS) [letter; comment] Science 265(5169):264-6. [PubMed: 8023146]  [MGI Ref ID J:19209]

Morimoto M; Morimoto M; Zhao A; Madden KB; Dawson H; Finkelman FD; Mentink-Kane M; Urban JF Jr; Wynn TA; Shea-Donohue T. 2006. Functional importance of regional differences in localized gene expression of receptors for IL-13 in murine gut. J Immunol 176(1):491-5. [PubMed: 16365442]  [MGI Ref ID J:126259]

Mottram PL; Raisanen-Sokolowski A; Glysing-Jensen T; Stein-Oakley AN; Russell ME. 1998. Cardiac allografts from IL-4 knockout recipients: assessment of transplant arteriosclerosis and peripheral tolerance. J Immunol 161(2):602-9. [PubMed: 9670933]  [MGI Ref ID J:119204]

Myers LK; Tang B; Stuart JM; Kang AH. 2002. The role of IL-4 in regulation of murine collagen-induced arthritis. Clin Immunol 102(2):185-91. [PubMed: 11846461]  [MGI Ref ID J:75149]

Nandakumar KS; Holmdahl R. 2006. Arthritis induced with cartilage-specific antibodiesis IL-4-dependent. Eur J Immunol 36(6):1608-18. [PubMed: 16688680]  [MGI Ref ID J:115066]

Nguyen DD; Maillard MH; Cotta-de-Almeida V; Mizoguchi E; Klein C; Fuss I; Nagler C; Mizoguchi A; Bhan AK; Snapper SB. 2007. Lymphocyte-dependent and Th2 cytokine-associated colitis in mice deficient in Wiskott-Aldrich syndrome protein. Gastroenterology 133(4):1188-97. [PubMed: 17764675]  [MGI Ref ID J:128391]

Ostlie N; Milani M; Wang W; Okita D; Conti-Fine BM. 2003. Absence of IL-4 facilitates the development of chronic autoimmune myasthenia gravis in C57BL/6 mice. J Immunol 170(1):604-12. [PubMed: 12496449]  [MGI Ref ID J:126274]

Ozaki K; Spolski R; Feng CG; Qi CF; Cheng J; Sher A; Morse HC rd; Liu C; Schwartzberg PL; Leonard WJ. 2002. A critical role for IL-21 in regulating immunoglobulin production. Science 298(5598):1630-4. [PubMed: 12446913]  [MGI Ref ID J:80474]

Patel DR; Kaplan MH; Chang CH. 2004. Altered Th1 cell differentiation programming by CIITA deficiency. J Immunol 173(9):5501-8. [PubMed: 15494498]  [MGI Ref ID J:93745]

Peng JK; Lin JS; Kung JT; Finkelman FD; Wu-Hsieh BA. 2005. The combined effect of IL-4 and IL-10 suppresses the generation of, but does not change the polarity of, type-1 T cells in Histoplasma infection. Int Immunol 17(2):193-205. [PubMed: 15642955]  [MGI Ref ID J:95565]

Peng SL; Moslehi J; Craft J. 1997. Roles of interferon-gamma and interleukin-4 in murine lupus. J Clin Invest 99(8):1936-46. [PubMed: 9109438]  [MGI Ref ID J:39600]

Pesce J; Kaviratne M; Ramalingam TR; Thompson RW; Urban JF Jr; Cheever AW; Young DA; Collins M; Grusby MJ; Wynn TA. 2006. The IL-21 receptor augments Th2 effector function and alternative macrophage activation. J Clin Invest 116(7):2044-55. [PubMed: 16778988]  [MGI Ref ID J:111712]

Petritus PM; Burns JM Jr. 2008. Suppression of lethal Plasmodium yoelii malaria following protective immunization requires antibody-, IL-4-, and IFN-gamma-dependent responses induced by vaccination and/or challenge infection. J Immunol 180(1):444-53. [PubMed: 18097046]  [MGI Ref ID J:130916]

Raisanen-Sokolowski A; Mottram PL; Glysing-Jensen T; Satoskar A; Russell ME. 1997. Heart transplants in interferon-gamma, interleukin 4, and interleukin 10 knockout mice. Recipient environment alters graft rejection. J Clin Invest 100(10):2449-56. [PubMed: 9366559]  [MGI Ref ID J:44346]

Rangachari M; Mauermann N; Marty RR; Dirnhofer S; Kurrer MO; Komnenovic V; Penninger JM; Eriksson U. 2006. T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17. J Exp Med 203(8):2009-19. [PubMed: 16880257]  [MGI Ref ID J:124393]

Reiter R; Pfeffer K. 2002. Impaired germinal centre formation and humoral immune response in the absence of CD28 and interleukin-4. Immunology 106(2):222-8. [PubMed: 12047751]  [MGI Ref ID J:113529]

Rizzo LV; Morawetz RA; Miller-Rivero NE; Choi R; Wiggert B; Chan CC; Morse HC rd; Nussenblatt RB; Caspi RR. 1999. IL-4 and IL-10 are both required for the induction of oral tolerance. J Immunol 162(5):2613-22. [PubMed: 10072503]  [MGI Ref ID J:110850]

Roberts MT; Stober CB; McKenzie AN; Blackwell JM. 2005. Interleukin-4 (IL-4) and IL-10 collude in vaccine failure for novel exacerbatory antigens in murine Leishmania major infection. Infect Immun 73(11):7620-8. [PubMed: 16239566]  [MGI Ref ID J:104289]

Sadlack B; Kuhn R; Schorle H; Rajewsky K; Muller W; Horak I. 1994. Development and proliferation of lymphocytes in mice deficient for both interleukins-2 and -4. Eur J Immunol 24(1):281-4. [PubMed: 7517363]  [MGI Ref ID J:16662]

Schmitz J; Thiel A; Kuhn R; Rajewsky K; Muller W; Assenmacher M; Radbruch A. 1994. Induction of interleukin 4 (IL-4) expression in T helper (Th) cells is not dependent on IL-4 from non-Th cells. J Exp Med 179(4):1349-53. [PubMed: 8145047]  [MGI Ref ID J:110776]

Segal BM; Dwyer BK; Shevach EM. 1998. An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease. J Exp Med 187(4):537-46. [PubMed: 9463404]  [MGI Ref ID J:118559]

Sehra S; Bruns HA; Ahyi AN; Nguyen ET; Schmidt NW; Michels EG; von Bulow GU; Kaplan MH. 2008. IL-4 Is a Critical Determinant in the Generation of Allergic Inflammation Initiated by a Constitutively Active Stat6. J Immunol 180(5):3551-9. [PubMed: 18292582]  [MGI Ref ID J:131555]

Serreze DV; Wasserfall C; Ottendorfer EW; Stalvey M; Pierce MA; Gauntt C; O'Donnell B; Flanagan JB; Campbell-Thompson M; Ellis TM; Atkinson MA. 2005. Diabetes acceleration or prevention by a coxsackievirus B4 infection: critical requirements for both interleukin-4 and gamma interferon. J Virol 79(2):1045-52. [PubMed: 15613333]  [MGI Ref ID J:95105]

Sirak JH; Orosz CG; Roopenian DC; Wakely E; VanBuskirk AM. 1998. Cardiac allograft tolerance: failure to develop in interleukin-4-deficient mice correlates with unusual allosensitization patterns. Transplantation 65(10):1352-6. [PubMed: 9625018]  [MGI Ref ID J:47988]

Skelsey ME; Mayhew E; Niederkorn JY. 2003. CD25+, interleukin-10-producing CD4+ T cells are required for suppressor cell production and immune privilege in the anterior chamber of the eye. Immunology 110(1):18-29. [PubMed: 12941137]  [MGI Ref ID J:113598]

Sosa MR; Rosas LE; McKenzie AN; Satoskar AR. 2001. IL-13 gene-deficient mice are susceptible to cutaneous L. mexicana infection. Eur J Immunol 31(11):3255-60. [PubMed: 11745342]  [MGI Ref ID J:72587]

Specht S; Volkmann L; Wynn T; Hoerauf A. 2004. Interleukin-10 (IL-10) counterregulates IL-4-dependent effector mechanisms in Murine Filariasis. Infect Immun 72(11):6287-93. [PubMed: 15501755]  [MGI Ref ID J:93273]

Svensson L; Arvola M; Sallstrom M; Holmdahl R; Mattsson R. 2001. The Th2 cytokines IL-4 and IL-10 are not crucial for the completion of allogeneic pregnancy in mice. J Reprod Immunol 51(1):3-7. [PubMed: 11438376]  [MGI Ref ID J:70597]

Tamura T; Igarashi O; Hino A; Yamane H; Aizawa S; Kato T; Nariuchi H. 2001. Impairment in the expression and activity of Fyn during differentiation of naive CD4+ T cells into the Th2 subset. J Immunol 167(4):1962-9. [PubMed: 11489976]  [MGI Ref ID J:110880]

Tan JT; Dudl E; LeRoy E; Murray R; Sprent J; Weinberg KI; Surh CD. 2001. IL-7 is critical for homeostatic proliferation and survival of naive T cells. Proc Natl Acad Sci U S A 98(15):8732-7. [PubMed: 11447288]  [MGI Ref ID J:93058]

Tang H; Sharp GC; Peterson KE; Braley-Mullen H. 1998. Induction of granulomatous experimental autoimmune thyroiditis in IL-4 gene-disrupted mice. J Immunol 160(1):155-62. [PubMed: 9551967]  [MGI Ref ID J:46310]

TeKippe M; Harrison DE; Chen J. 2003. Expansion of hematopoietic stem cell phenotype and activity in Trp53-null mice. Exp Hematol 31(6):521-7. [PubMed: 12829028]  [MGI Ref ID J:115677]

Texido G; Jacobs H; Meiering M; Kuhn R; Roes J; Muller W; Gilfillan S; Fujiwara H; Kikutani H; Yoshida N; Amakawa R; Benoist C; Mathis D; Kishimoto T; Mak TW; Rajewsky K. 1996. Somatic hypermutation occurs in B cells of terminal deoxynucleotidyl transferase-, CD23-, interleukin-4-, IgD- and CD30-deficient mouse mutants. Eur J Immunol 26(8):1966-9. [PubMed: 8765046]  [MGI Ref ID J:34589]

Thackray AM; McKenzie AN; Klein MA; Lauder A; Bujdoso R. 2004. Accelerated prion disease in the absence of interleukin-10. J Virol 78(24):13697-707. [PubMed: 15564479]  [MGI Ref ID J:94220]

Thieu VT; Nguyen ET; McCarthy BP; Bruns HA; Kapur R; Chang CH; Kaplan MH. 2007. IL-4-stimulated NF-kappaB activity is required for Stat6 DNA binding. J Leukoc Biol 82(2):370-9. [PubMed: 17513694]  [MGI Ref ID J:123512]

Ueda N; Kuki H; Kamimura D; Sawa S; Seino K; Tashiro T; Fushuku K; Taniguchi M; Hirano T; Murakami M. 2006. CD1d-restricted NKT cell activation enhanced homeostatic proliferation of CD8+ T cells in a manner dependent on IL-4. Int Immunol 18(9):1397-404. [PubMed: 16914507]  [MGI Ref ID J:113387]

Ueno A; Cho S; Cheng L; Wang Z; Wang B; Yang Y. 2005. Diabetes resistance/susceptibility in T cells of nonobese diabetic mice conferred by MHC and MHC-linked genes. J Immunol 175(8):5240-7. [PubMed: 16210629]  [MGI Ref ID J:119112]

Ueno A; Wang J; Cheng L; Im JS; Shi Y; Porcelli SA; Yang Y. 2008. Enhanced early expansion and maturation of semi-invariant NK T cells inhibited autoimmune pathogenesis in congenic nonobese diabetic mice. J Immunol 181(10):6789-96. [PubMed: 18981096]  [MGI Ref ID J:140949]

Urban JF Jr; Noben-Trauth N; Donaldson DD; Madden KB; Morris SC; Collins M; Finkelman FD. 1998. IL-13, IL-4Ralpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis. Immunity 8(2):255-64. [PubMed: 9492006]  [MGI Ref ID J:110429]

VanLith ML; Kohlgraf KG; Sivinski CL; Tempero RM; Hollingsworth MA. 2002. MUC1-specific anti-tumor responses: molecular requirements for CD4-mediated responses. Int Immunol 14(8):873-82. [PubMed: 12147624]  [MGI Ref ID J:113544]

Vivien L; Benoist C; Mathis D. 2001. T lymphocytes need IL-7 but not IL-4 or IL-6 to survive in vivo. Int Immunol 13(6):763-8. [PubMed: 11369703]  [MGI Ref ID J:69776]

Vosshenrich CA; Ranson T; Samson SI; Corcuff E; Colucci F; Rosmaraki EE; Di Santo JP. 2005. Roles for common cytokine receptor gamma-chain-dependent cytokines in the generation, differentiation, and maturation of NK cell precursors and peripheral NK cells in vivo. J Immunol 174(3):1213-21. [PubMed: 15661875]  [MGI Ref ID J:96422]

Wang B; Gonzalez A; Hoglund P; Katz JD; Benoist C; Mathis D. 1998. Interleukin-4 deficiency does not exacerbate disease in NOD mice. Diabetes 47(8):1207-11. [PubMed: 9703318]  [MGI Ref ID J:85924]

Williams DM; Grubbs BG; Pack E; Kelly K; Rank RG. 1997. Humoral and cellular immunity in secondary infection due to murine Chlamydia trachomatis. Infect Immun 65(7):2876-82. [PubMed: 9199462]  [MGI Ref ID J:41109]

Wynn TA; Morawetz R; Scharton-Kersten T; Hieny S; Morse HC 3rd ; Kuhn R ; Muller W ; Cheever AW ; Sher A. 1997. Analysis of granuloma formation in double cytokine-deficient mice reveals a central role for IL-10 in polarizing both T helper cell 1- and T helper cell 2-type cytokine responses in vivo. J Immunol 159(10):5014-23. [PubMed: 9366429]  [MGI Ref ID J:44069]

Yu S; Sharp GC; Braley-Mullen H. 2008. TGF-beta promotes thyroid epithelial cell hyperplasia and fibrosis in IFN-gamma-deficient NOD.H-2h4 mice. J Immunol 181(3):2238-45. [PubMed: 18641364]  [MGI Ref ID J:139224]

Yu S; Sharp GC; Braley-Mullen H. 2006. Thyroid epithelial cell hyperplasia in IFN-gamma deficient NOD.H-2h4 mice. Clin Immunol 118(1):92-100. [PubMed: 16150647]  [MGI Ref ID J:107231]

Zhang W; Kong YC. 1998. Noninvolvement of IL-4 and IL-10 in tolerance induction to experimental autoimmune thyroiditis. Cell Immunol 187(2):95-102. [PubMed: 9732697]  [MGI Ref ID J:114207]

Zhang Y; Rogers KH; Lewis DB. 1996. Beta 2-microglobulin-dependent T cells are dispensable for allergen-induced T helper 2 responses. J Exp Med 184(4):1507-12. [PubMed: 8879221]  [MGI Ref ID J:39962]

van Rossum AM; Lysenko ES; Weiser JN. 2005. Host and bacterial factors contributing to the clearance of colonization by Streptococcus pneumoniae in a murine model. Infect Immun 73(11):7718-26. [PubMed: 16239576]  [MGI Ref ID J:104292]

Health & husbandry

Health & Colony Maintenance Information

Currently there no information available for this strain. This may be due to the supply level of this strain.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations View International pricing
Weeks of AgePrice*Gender
Cryorecovery Fee $1900.00
*Price(s) in US dollars ($)

Additional Supply Details

Pricing for International shipping destinations View USA Canada and Mexico pricing
Weeks of AgePrice*Gender
Cryorecovery Fee $2470.00
*Price(s) in US dollars ($)

Additional Supply Details

Supply Details

Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes
  • Cryorecovery - Standard.
    The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 or 1-207-288-5845.

  • This strain is included in the Type 1 Diabetes Repository collection.

Control Information

  Control
   001976 NOD/ShiLtJ
 
  Considerations for Choosing Controls
  USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
  International - Control Pricing Information for Genetically Engineered Mutant Strains.

General Terms and Conditions


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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of MICE, products or services, The Jackson Laboratory will, at its option, provide credit or replacement for the MICE or product received or the services provided.

No Liability

In no event shall The Jackson Laboratory, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, products or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of The Jackson Laboratory, its agents or employees. In purchasing or receiving MICE, products or services from The Jackson Laboratory, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges The Jackson Laboratory from all such causes of action or damages, and further agrees to defend and indemnify The Jackson Laboratory from any costs or damages arising out of any third party claims.

MICE and biological materials are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to The Jackson Laboratory’s MICE, products and services. In addition, special terms and conditions of sale of certain MICE, products and services may be set forth separately in The Jackson Laboratory web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, products and services by The Jackson Laboratory, and by its licensees and distributors.

Acceptance of delivery of MICE, products or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on The Jackson Laboratory, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, products services by The Jackson Laboratory.


(3.2)