Strain Name:

NOD.129P2(B6)-Il4tm1Cgn/DvsJ

Stock Number:

004222

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Availability:

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Mice homozygous for Il4tm1Cgn have a reduced ability to produce Th2-derived cytokines. IL4 deficient NOD mice develop IDDM with the same incidence as standard NOD/Lt controls.

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain NOD/ShiLt
Donor Strain 129P2
H2 Haplotypeg7
 
Donating InvestigatorDr. David Serreze,   The Jackson Laboratory

Appearance
albino, pink eyed
Related Genotype: A/A Tyrc/Tyrc

Description
Complete Freund's adjuvant (CFA) induced suppression of diabetes in NOD mice has been associated with a shift to Th2 cytokine production. NOD mice deficient in IL4 were created to investigate the role of IL4 in this shift. Mice homozygous for the Il4tm1Cgn targeted mutation are viable and fertile. T and B cell development is normal but IgG1and IgE levels and the ability of homozygous mutant mice to produce Th2-derived cytokines are significantly reduced. IL4 deficient NOD mice develop IDDM with the same incidence as standard NOD/Lt controls, and there is no change between IL4 deficient and wildtype NOD in disease protection conferred by treatment of bacillus Calmette-Guerin vaccine (BCG) or CFA. Both IL4 deficient and wildtype NOD mice are significantly protected from insulitis by treatment of CFA but not by treatment of BCG. (Serreze et al 2001)

Development
A 4.5 kb targeting vector containing the first two exons of the Il4 gene and a neomycin resistance cassette was used to disrupt the first exon of Il4. This construct was transfected into E14-1 embryonic stem cells (derived from 129P2/OlaHsd). Correctly targeted ES cells were injected into C57BL/6 blastocysts. The mutation was maintained on a B6;129 segregating background until it was congenically transferred to NOD/Lt using a marker assisted protocol. At the sixth backcross generation, mice heterozygous for the Il4tm1Cgn mutation and homozygous for all insulin dependent diabetes susceptibility loci (Idd) were intercrossed to produce mice homozygous for the mutation and all Idds. This strain is maintained by sibling mating homozygotes. (Kuhn et al., 1991; Serreze et al., 2001.)

Control Information

  Control
   001976 NOD/ShiLtJ
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Il4tm1Cgn allele
002253   B6.129P2-Il4tm1Cgn/J
005879   D1Lac.Cg-Il4tm1Cgn/J
002574   NOD.129P2(B6)-Il4tm1Cgn/Dvs
004291   NOD.Cg-Il10tm1Cgn Il4tm1Cgn/DvsJ
View Strains carrying   Il4tm1Cgn     (4 strains)

Strains carrying other alleles of Il4
002496   BALB/c-Il4tm2Nnt/J
004190   C.129-Il4tm1Lky/J
015859   C.129P2(Cg)-Il4/Il13tm1.1Lky/J
003480   C.129S2(B6)-Il4tm1Gru/J
002518   C57BL/6-Il4tm1Nnt/J
002230   C57BL/6J-Tg(LckIl4)1315Dbl/J
006698   NOD.Cg-Il4tm1Lky/JbsJ
View Strains carrying other alleles of Il4     (7 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Model with phenotypic similarity to human disease where etiologies are distinct. Human genes are associated with this disease. Orthologs of these genes do not appear in the mouse genotype(s).
Diabetes Mellitus, Insulin-Dependent; IDDM
Models with phenotypic similarity to human diseases where etiology is unknown or involving genes where ortholog is unknown.
Sjogren Syndrome
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Il4tm1Cgn/Il4tm1Cgn

        NOD.129P2-Il4tm1Cgn
  • homeostasis/metabolism phenotype
  • abnormal enzyme/coenzyme activity
    • amylase activity increases slightly between 4 and 20 weeks of age (234 to 291 U/L) compared to activity in wild-type which declines   (MGI Ref ID J:105803)
    • parotid secretory protein protease activity is retained in mutants while non-diseased BALB/c animals do not show activity   (MGI Ref ID J:105803)
  • increased circulating glucose level
    • mice are diabetic if 2 consecutive measures of blood glucose are >240 mg/dl   (MGI Ref ID J:95105)
  • endocrine/exocrine gland phenotype
  • abnormal salivary gland physiology
    • mice do not exhibit a decrease in salivary flow rates compared to NOD.B10-H2b mice at 4 weeks of age   (MGI Ref ID J:105803)
    • saliva maintains normal protein concentrations compared to NOD and NOD.B10-H2b controls   (MGI Ref ID J:105803)
  • immune system phenotype
  • decreased susceptibility to autoimmune disorder
    • in null females challenged with coxsackievirus B4 at 8 weeks of age, diabetes onset is not accelerated as it is in wild-type NOD females; over the 25-week follow up period, only 23% of CVB4 exposed nulls develop diabetes compared to 63% of saline-treated controls   (MGI Ref ID J:95105)
  • increased susceptibility to autoimmune disorder
    • at 12 weeks of age, null females challenged with CVB4 develop diabetes at an accelerated rate compared with saline-treated controls (80% at 10 days after infection versus 30% of controls)   (MGI Ref ID J:95105)
  • digestive/alimentary phenotype
  • abnormal salivary gland physiology
    • mice do not exhibit a decrease in salivary flow rates compared to NOD.B10-H2b mice at 4 weeks of age   (MGI Ref ID J:105803)
    • saliva maintains normal protein concentrations compared to NOD and NOD.B10-H2b controls   (MGI Ref ID J:105803)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Il4tm1Cgn/Il4tm1Cgn

        NOD.Cg-H2b Il4tm1Cgn
  • homeostasis/metabolism phenotype
  • abnormal enzyme/coenzyme activity
    • amylase activity increases slightly between 4 and 20 weeks of age(181 to 250 U/L) compared to activity in wild-type which decreases (386 to 288 U/L)   (MGI Ref ID J:105803)
    • parotid secretory protein protease activity is retained in mutants while non-diseased animals do not show activity   (MGI Ref ID J:105803)
  • endocrine/exocrine gland phenotype
  • abnormal salivary gland physiology
    • mice do not exhibit a decrease in salivary flow rates compared to NOD.B10-H2b mice at 4 weeks of age; normal salivary flow is retained to 36 weeks of age compared to controls   (MGI Ref ID J:105803)
    • saliva maintains normal protein concentrations compared to NOD and NOD.B10-H2b controls   (MGI Ref ID J:105803)
    • salivary gland inflammation
      • foci of leukocytic infiltration contain more T cells than NOD.B10-H2b controls   (MGI Ref ID J:105803)
  • lacrimal gland inflammation
    • foci of leukocytic infiltration contain more T cells than NOD.B10-H2b controls   (MGI Ref ID J:105803)
  • immune system phenotype
  • lacrimal gland inflammation
    • foci of leukocytic infiltration contain more T cells than NOD.B10-H2b controls   (MGI Ref ID J:105803)
  • salivary gland inflammation
    • foci of leukocytic infiltration contain more T cells than NOD.B10-H2b controls   (MGI Ref ID J:105803)
  • vision/eye phenotype
  • lacrimal gland inflammation
    • foci of leukocytic infiltration contain more T cells than NOD.B10-H2b controls   (MGI Ref ID J:105803)
  • digestive/alimentary phenotype
  • abnormal salivary gland physiology
    • mice do not exhibit a decrease in salivary flow rates compared to NOD.B10-H2b mice at 4 weeks of age; normal salivary flow is retained to 36 weeks of age compared to controls   (MGI Ref ID J:105803)
    • saliva maintains normal protein concentrations compared to NOD and NOD.B10-H2b controls   (MGI Ref ID J:105803)
    • salivary gland inflammation
      • foci of leukocytic infiltration contain more T cells than NOD.B10-H2b controls   (MGI Ref ID J:105803)

Il4tm1Cgn/Il4tm1Cgn

        involves: 129P2/OlaHsd * NOD
  • immune system phenotype
  • abnormal cytokine secretion
    • CD4+ T cells from deficient animals show a strongly reduced ability to produce Il5 after anti-TCR stimulation compared to wild-type cells   (MGI Ref ID J:85924)
  • decreased IgG1 level
    • CD4+ T cells from deficient animals show a reduction in circulating IgG1 in the absence of deliberate immunization   (MGI Ref ID J:85924)
  • hematopoietic system phenotype
  • decreased IgG1 level
    • CD4+ T cells from deficient animals show a reduction in circulating IgG1 in the absence of deliberate immunization   (MGI Ref ID J:85924)

Il4tm1Cgn/Il4tm1Cgn

        either: NOD.129-Il4tm1Cgn or (involves: 129 * NOD)
  • endocrine/exocrine gland phenotype
  • insulitis
    • at 12 weeks, insulitis incidence is similar in homozygous mutants and heterozygous controls on the NOD background (N4)   (MGI Ref ID J:85924)
  • immune system phenotype
  • autoimmune response
    • there is no difference in timing or penetrance of diabetes in IL4-deficient NOD mice (N8) compared to heterozygous or wild-type NOD mice   (MGI Ref ID J:85924)
  • insulitis
    • at 12 weeks, insulitis incidence is similar in homozygous mutants and heterozygous controls on the NOD background (N4)   (MGI Ref ID J:85924)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Diabetes and Obesity Research
Impaired Wound Healing
Islet Transplantation Studies
Type 1 Diabetes (IDDM)
      Congenics with mutations affecting cytokine production by autoreactive T cells
Type 1 Diabetes (IDDM) Analysis Strains
      NOD Congenics with Mutations Affecting Cytokine Production by Autoreactive T Cells
      NOD Congenics with Mutations Affecting Immunocompetence

Hematological Research
Immunological Defects

Immunology, Inflammation and Autoimmunity Research
Immunodeficiency
      specific T cell deficiency
Immunodeficiency Associated with Other Defects
Inflammation
Lymphoid Tissue Defects
Vaccine Development

Internal/Organ Research
Wound Healing

Research Tools
Cancer Research
      T cell deficiency
      xenograft/transplant host
Immunology, Inflammation and Autoimmunity Research
      genes regulating susceptibility to infectious disease and endotoxin
      production of T cell lines and hybridomas
      specific T cell deficiency
Internal/Organ Research
Toxicology Research
      B and T cell deficiency, xenograft transplant host

Il4tm1Cgn related

Cancer Research
Growth Factors/Receptors/Cytokines

Immunology, Inflammation and Autoimmunity Research
Growth Factors/Receptors/Cytokines

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Il4tm1Cgn
Allele Name targeted mutation 1, University of Cologne
Allele Type Targeted (Null/Knockout)
Common Name(s) IL-4 KO; IL-4-; IL-4KO; IL-4T-; IL4-; IL4tm1cgn129; IL4T;
Mutation Made ByDr. Ralf Kuhn,   University of Cologne
Strain of Origin129P2/OlaHsd
ES Cell Line NameE14.1
ES Cell Line Strain129P2/OlaHsd
Gene Symbol and Name Il4, interleukin 4
Chromosome 11
Gene Common Name(s) BCGF-1; BCGF1; BSF-1; BSF1; IL-4; Il-4; Il4e12;
Molecular Note A translational stop codon and a neomycin resistance gene were inserted into the first exon of the gene. [MGI Ref ID J:704]

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Il4tm1Cgn related

Aguirre SA; Perryman LE; Davis WC; McGuire TC. 1998. IL-4 protects adult C57BL/6 mice from prolonged Cryptosporidium parvum infection: analysis of CD4+alpha beta+IFN-gamma+ and CD4+alpha beta+IL-4+ lymphocytes in gut-associated lymphoid tissue during resolution of infection. J Immunol 161(4):1891-900. [PubMed: 9712058]  [MGI Ref ID J:49699]

Alard P; Clark SL; Kosiewicz MM. 2004. Mechanisms of tolerance induced by TGF beta-treated APC: CD4 regulatory T cells prevent the induction of the immune response possibly through a mechanism involving TGF beta. Eur J Immunol 34(4):1021-30. [PubMed: 15048712]  [MGI Ref ID J:115475]

Andersen C; Jensen T; Nansen A; Marker O; Thomsen AR. 1999. CD4(+) T cell-mediated protection against a lethal outcome of systemic infection with vesicular stomatitis virus requires CD40 ligand expression, but not IFN-gamma or IL-4. Int Immunol 11(12):2035-42. [PubMed: 10590269]  [MGI Ref ID J:110491]

Anderson AC; Reddy J; Nazareno R; Sobel RA; Nicholson LB; Kuchroo VK. 2004. IL-10 plays an important role in the homeostatic regulation of the autoreactive repertoire in naive mice. J Immunol 173(2):828-34. [PubMed: 15240669]  [MGI Ref ID J:91913]

Babayan SA; Read AF; Lawrence RA; Bain O; Allen JE. 2010. Filarial parasites develop faster and reproduce earlier in response to host immune effectors that determine filarial life expectancy. PLoS Biol 8(10):e1000525. [PubMed: 20976099]  [MGI Ref ID J:167364]

Bachmann MF; Schorle H; Kuhn R; Muller W; Hengartner H; Zinkernagel RM; Horak I. 1995. Antiviral immune responses in mice deficient for both interleukin-2 and interleukin-4. J Virol 69(8):4842-6. [PubMed: 7609051]  [MGI Ref ID J:26861]

Bagley J; Sawada T; Wu Y; Iacomini J. 2000. A critical role for interleukin 4 in activating alloreactive CD4 T cells. Nat Immunol 1(3):257-61. [PubMed: 10973285]  [MGI Ref ID J:118019]

Bancroft AJ; Artis D; Donaldson DD; Sypek JP; Grencis RK. 2000. Gastrointestinal nematode expulsion in IL-4 knockout mice is IL-13 dependent. Eur J Immunol 30(7):2083-91. [PubMed: 10940898]  [MGI Ref ID J:63513]

Bancroft AJ; McKenzie AN; Grencis RK. 1998. A critical role for IL-13 in resistance to intestinal nematode infection. J Immunol 160(7):3453-61. [PubMed: 9531306]  [MGI Ref ID J:111618]

Beal AM; Ramos-Hernandez N; Riling CR; Nowelsky EA; Oliver PM. 2011. TGF-beta induces the expression of the adaptor Ndfip1 to silence IL-4 production during iT(reg) cell differentiation. Nat Immunol 13(1):77-85. [PubMed: 22080920]  [MGI Ref ID J:179003]

Bediako Y; Bian Y; Zhang H; Cho H; Stein PL; Wang CR. 2012. SAP is required for the development of innate phenotype in H2-M3--restricted Cd8(+) T cells. J Immunol 189(10):4787-96. [PubMed: 23041566]  [MGI Ref ID J:190592]

Beenhouwer DO; Shapiro S; Feldmesser M; Casadevall A; Scharff MD. 2001. Both Th1 and Th2 Cytokines Affect the Ability of Monoclonal Antibodies To Protect Mice against Cryptococcus neoformans. Infect Immun 69(10):6445-55. [PubMed: 11553589]  [MGI Ref ID J:71570]

Belghith M; Bluestone JA; Barriot S; Megret J; Bach JF; Chatenoud L. 2003. TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes. Nat Med 9(9):1202-8. [PubMed: 12937416]  [MGI Ref ID J:85362]

Belkaid Y; Hoffmann KF; Mendez S; Kamhawi S; Udey MC; Wynn TA; Sacks DL. 2001. The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure. J Exp Med 194(10):1497-506. [PubMed: 11714756]  [MGI Ref ID J:118003]

Berg DJ; Leach MW; Kuhn R; Rajewsky K; Muller W; Davidson NJ; Rennick D. 1995. Interleukin 10 but not interleukin 4 is a natural suppressant of cutaneous inflammatory responses. J Exp Med 182(1):99-108. [PubMed: 7790826]  [MGI Ref ID J:26221]

Bettelli E; Das MP; Howard ED; Weiner HL; Sobel RA; Kuchroo VK. 1998. IL-10 is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10- and IL-4-deficient and transgenic mice. J Immunol 161(7):3299-306. [PubMed: 9759845]  [MGI Ref ID J:115204]

Bezbradica JS; Gordy LE; Stanic AK; Dragovic S; Hill T; Hawiger J; Unutmaz D; Van Kaer L; Joyce S. 2006. Granulocyte-macrophage colony-stimulating factor regulates effector differentiation of invariant natural killer T cells during thymic ontogeny. Immunity 25(3):487-97. [PubMed: 16949316]  [MGI Ref ID J:113451]

Blackstock R; Murphy JW. 2004. Role of interleukin-4 in resistance to Cryptococcus neoformans infection. Am J Respir Cell Mol Biol 30(1):109-17. [PubMed: 12855407]  [MGI Ref ID J:95350]

Bour-Jordan H; Thompson HL; Bluestone JA. 2005. Distinct effector mechanisms in the development of autoimmune neuropathy versus diabetes in nonobese diabetic mice. J Immunol 175(9):5649-55. [PubMed: 16237054]  [MGI Ref ID J:119359]

Brayer JB; Cha S; Nagashima H; Yasunari U; Lindberg A; Diggs S; Martinez J; Goa J; Humphreys-Beher MG; Peck AB. 2001. IL-4-dependent effector phase in autoimmune exocrinopathy as defined by the NOD.IL-4-gene knockout mouse model of Sjogren's syndrome. Scand J Immunol 54(1-2):133-40. [PubMed: 11439159]  [MGI Ref ID J:103875]

Briesemeister D; Friese C; Isern CC; Dietz E; Blankenstein T; Thoene-Reineke C; Kammertoens T. 2012. Differences in serum cytokine levels between wild type mice and mice with a targeted mutation suggests necessity of using control littermates. Cytokine 60(3):626-33. [PubMed: 22902947]  [MGI Ref ID J:192770]

Brunn A; Mihelcic M; Carstov M; Hummel L; Geier F; Schmidt A; Saupe L; Utermohlen O; Deckert M. 2014. IL-10, IL-4, and STAT6 promote an M2 milieu required for termination of P0(106-125)-induced murine experimental autoimmune neuritis. Am J Pathol 184(10):2627-40. [PubMed: 25108223]  [MGI Ref ID J:214835]

Cain JA; Smith JA; Ondr JK; Wang B; Katz JD. 2006. NKT cells and IFN-gamma establish the regulatory environment for the control of diabetogenic T cells in the nonobese diabetic mouse. J Immunol 176(3):1645-54. [PubMed: 16424194]  [MGI Ref ID J:126603]

Chiaramonte MG; Mentink-Kane M; Jacobson BA; Cheever AW; Whitters MJ; Goad ME; Wong A; Collins M; Donaldson DD; Grusby MJ; Wynn TA. 2003. Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response. J Exp Med 197(6):687-701. [PubMed: 12642601]  [MGI Ref ID J:124413]

Cole N; Hume EB; Khan S; Garthwaite L; Schubert T; Reeve V; Willcox MD. 2007. The corneal response to infection with Staphylococcus aureus in the absence of interleukin-4. Immunol Cell Biol 85(4):333-7. [PubMed: 17389870]  [MGI Ref ID J:122715]

Crow AR; Song S; Semple JW; Freedman J; Lazarus AH. 2007. A role for IL-1 receptor antagonist or other cytokines in the acute therapeutic effects of IVIg? Blood 109(1):155-8. [PubMed: 16954498]  [MGI Ref ID J:142178]

Cunningham AF; Fallon PG; Khan M; Vacheron S; Acha-Orbea H; MacLennan IC; McKenzie AN; Toellner KM. 2002. Th2 activities induced during virgin T cell priming in the absence of IL-4, IL-13, and B cells. J Immunol 169(6):2900-6. [PubMed: 12218103]  [MGI Ref ID J:120432]

D'Orazio TJ; Niederkorn JY. 1998. A novel role for TGF-beta and IL-10 in the induction of immune privilege. J Immunol 160(5):2089-98. [PubMed: 9498745]  [MGI Ref ID J:111362]

Denzel A; Maus UA; Rodriguez Gomez M; Moll C; Niedermeier M; Winter C; Maus R; Hollingshead S; Briles DE; Kunz-Schughart LA; Talke Y; Mack M. 2008. Basophils enhance immunological memory responses. Nat Immunol 9(7):733-42. [PubMed: 18516038]  [MGI Ref ID J:137679]

Derecki NC; Cardani AN; Yang CH; Quinnies KM; Crihfield A; Lynch KR; Kipnis J. 2010. Regulation of learning and memory by meningeal immunity: a key role for IL-4. J Exp Med 207(5):1067-80. [PubMed: 20439540]  [MGI Ref ID J:160932]

Diaz-de-Durana Y; Mantchev GT; Bram RJ; Franco A. 2006. TACI-BLyS signaling via B-cell-dendritic cell cooperation is required for naive CD8+ T-cell priming in vivo. Blood 107(2):594-601. [PubMed: 16195331]  [MGI Ref ID J:126637]

Dieli F; Sireci G; Scire E; Salerno A; Bellavia A. 1999. Impaired contact hypersensitivity to trinitrochlorobenzene in interleukin-4-deficient mice. Immunology 98(1):71-9. [PubMed: 10469236]  [MGI Ref ID J:110461]

Dohi T; Fujihashi K; Koga T; Etani Y; Yoshino N; Kawamura YI; McGhee JR. 2004. CD4+CD45RBHi interleukin-4 defective T cells elicit antral gastritis and duodenitis. Am J Pathol 165(4):1257-68. [PubMed: 15466391]  [MGI Ref ID J:93676]

Emson CL; Bell SE; Jones A; Wisden W; McKenzie AN. 1998. Interleukin (IL)-4-independent induction of immunoglobulin (Ig)E, and perturbation of T cell development in transgenic mice expressing IL-13. J Exp Med 188(2):399-404. [PubMed: 9670052]  [MGI Ref ID J:112473]

Everest P; Allen J; Papakonstantinopoulou A; Mastroeni P; Roberts M ; Dougan G. 1997. Salmonella typhimurium infections in mice deficient in interleukin-4 production: role of IL-4 in infection-associated pathology. J Immunol 159(4):1820-7. [PubMed: 9257845]  [MGI Ref ID J:42104]

Fallon PG; Ballantyne SJ; Mangan NE; Barlow JL; Dasvarma A; Hewett DR; McIlgorm A; Jolin HE; McKenzie AN. 2006. Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion. J Exp Med 203(4):1105-16. [PubMed: 16606668]  [MGI Ref ID J:123748]

Fallon PG; Emson CL; Smith P; McKenzie AN. 2001. IL-13 overexpression predisposes to anaphylaxis following antigen sensitization. J Immunol 166(4):2712-6. [PubMed: 11160336]  [MGI Ref ID J:135014]

Fallon PG; Jolin HE; Smith P; Emson CL; Townsend MJ; Fallon R; Smith P; McKenzie AN. 2002. IL-4 induces characteristic Th2 responses even in the combined absence of IL-5, IL-9, and IL-13. Immunity 17(1):7-17. [PubMed: 12150887]  [MGI Ref ID J:113543]

Fang M; Xie H; Dougan SK; Ploegh H; van Oudenaarden A. 2013. Stochastic cytokine expression induces mixed T helper cell States. PLoS Biol 11(7):e1001618. [PubMed: 23935453]  [MGI Ref ID J:201603]

Fousteri G; Dave A; Bot A; Juntti T; Omid S; von Herrath M. 2010. Subcutaneous insulin B:9-23/IFA immunisation induces Tregs that control late-stage prediabetes in NOD mice through IL-10 and IFNgamma. Diabetologia 53(9):1958-70. [PubMed: 20490452]  [MGI Ref ID J:163357]

French AR; Sjolin H; Kim S; Koka R; Yang L; Young DA; Cerboni C; Tomasello E; Ma A; Vivier E; Karre K; Yokoyama WM. 2006. DAP12 signaling directly augments proproliferative cytokine stimulation of NK cells during viral infections. J Immunol 177(8):4981-90. [PubMed: 17015680]  [MGI Ref ID J:139300]

Gao J; Killedar S; Cornelius JG; Nguyen C; Cha S; Peck AB. 2006. Sjogren's syndrome in the NOD mouse model is an interleukin-4 time-dependent, antibody isotype-specific autoimmune disease. J Autoimmun 26(2):90-103. [PubMed: 16413168]  [MGI Ref ID J:105803]

Gocheva V; Wang HW; Gadea BB; Shree T; Hunter KE; Garfall AL; Berman T; Joyce JA. 2010. IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion. Genes Dev 24(3):241-55. [PubMed: 20080943]  [MGI Ref ID J:156936]

Gonzalez A; Andre-Schmutz I; Carnaud C; Mathis D; Benoist C. 2001. Damage control, rather than unresponsiveness, effected by protective DX5+ T cells in autoimmune diabetes. Nat Immunol 2(12):1117-25. [PubMed: 11713466]  [MGI Ref ID J:109860]

Grunewald SM; Werthmann A; Schnarr B; Klein CE; Brocker EB; Mohrs M ; Brombacher F ; Sebald W ; Duschl A. 1998. An antagonistic IL-4 mutant prevents type I allergy in the mouse: inhibition of the IL-4/IL-13 receptor system completely abrogates humoral immune response to allergen and development of allergic symptoms in vivo. J Immunol 160(8):4004-9. [PubMed: 9558109]  [MGI Ref ID J:47244]

Han H; Headley MB; Xu W; Comeau MR; Zhou B; Ziegler SF. 2013. Thymic stromal lymphopoietin amplifies the differentiation of alternatively activated macrophages. J Immunol 190(3):904-12. [PubMed: 23275605]  [MGI Ref ID J:193032]

Hao J; Dong S; Xia S; He W; Jia H; Zhang S; Wei J; O'Brien RL; Born WK; Wu Z; Wang P; Han J; Hong Z; Zhao L; Yin Z. 2011. Regulatory role of Vgamma1 gammadelta T cells in tumor immunity through IL-4 production. J Immunol 187(10):4979-86. [PubMed: 21987661]  [MGI Ref ID J:179639]

Harris DP; Goodrich S; Mohrs K; Mohrs M; Lund FE. 2005. Cutting edge: the development of IL-4-producing B cells (B effector 2 cells) is controlled by IL-4, IL-4 receptor alpha, and Th2 cells. J Immunol 175(11):7103-7. [PubMed: 16301612]  [MGI Ref ID J:122200]

Hasnain SZ; Evans CM; Roy M; Gallagher AL; Kindrachuk KN; Barron L; Dickey BF; Wilson MS; Wynn TA; Grencis RK; Thornton DJ. 2011. Muc5ac: a critical component mediating the rejection of enteric nematodes. J Exp Med 208(5):893-900. [PubMed: 21502330]  [MGI Ref ID J:177306]

Havarinasab S; Haggqvist B; Bjorn E; Pollard KM; Hultman P. 2005. Immunosuppressive and autoimmune effects of thimerosal in mice. Toxicol Appl Pharmacol 204(2):109-21. [PubMed: 15808517]  [MGI Ref ID J:97345]

Havarinasab S; Pollard KM; Hultman P. 2009. Gold- and silver-induced murine autoimmunity--requirement for cytokines and CD28 in murine heavy metal-induced autoimmunity. Clin Exp Immunol 155(3):567-76. [PubMed: 19077085]  [MGI Ref ID J:146057]

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Tan JT; Dudl E; LeRoy E; Murray R; Sprent J; Weinberg KI; Surh CD. 2001. IL-7 is critical for homeostatic proliferation and survival of naive T cells. Proc Natl Acad Sci U S A 98(15):8732-7. [PubMed: 11447288]  [MGI Ref ID J:93058]

Tang H; Sharp GC; Peterson KE; Braley-Mullen H. 1998. Induction of granulomatous experimental autoimmune thyroiditis in IL-4 gene-disrupted mice. J Immunol 160(1):155-62. [PubMed: 9551967]  [MGI Ref ID J:46310]

TeKippe M; Harrison DE; Chen J. 2003. Expansion of hematopoietic stem cell phenotype and activity in Trp53-null mice. Exp Hematol 31(6):521-7. [PubMed: 12829028]  [MGI Ref ID J:115677]

Texido G; Jacobs H; Meiering M; Kuhn R; Roes J; Muller W; Gilfillan S; Fujiwara H; Kikutani H; Yoshida N; Amakawa R; Benoist C; Mathis D; Kishimoto T; Mak TW; Rajewsky K. 1996. Somatic hypermutation occurs in B cells of terminal deoxynucleotidyl transferase-, CD23-, interleukin-4-, IgD- and CD30-deficient mouse mutants. Eur J Immunol 26(8):1966-9. [PubMed: 8765046]  [MGI Ref ID J:34589]

Thackray AM; McKenzie AN; Klein MA; Lauder A; Bujdoso R. 2004. Accelerated prion disease in the absence of interleukin-10. J Virol 78(24):13697-707. [PubMed: 15564479]  [MGI Ref ID J:94220]

Thieu VT; Nguyen ET; McCarthy BP; Bruns HA; Kapur R; Chang CH; Kaplan MH. 2007. IL-4-stimulated NF-kappaB activity is required for Stat6 DNA binding. J Leukoc Biol 82(2):370-9. [PubMed: 17513694]  [MGI Ref ID J:123512]

Ueda N; Kuki H; Kamimura D; Sawa S; Seino K; Tashiro T; Fushuku K; Taniguchi M; Hirano T; Murakami M. 2006. CD1d-restricted NKT cell activation enhanced homeostatic proliferation of CD8+ T cells in a manner dependent on IL-4. Int Immunol 18(9):1397-404. [PubMed: 16914507]  [MGI Ref ID J:113387]

Ueno A; Cho S; Cheng L; Wang Z; Wang B; Yang Y. 2005. Diabetes resistance/susceptibility in T cells of nonobese diabetic mice conferred by MHC and MHC-linked genes. J Immunol 175(8):5240-7. [PubMed: 16210629]  [MGI Ref ID J:119112]

Ueno A; Wang J; Cheng L; Im JS; Shi Y; Porcelli SA; Yang Y. 2008. Enhanced early expansion and maturation of semi-invariant NK T cells inhibited autoimmune pathogenesis in congenic nonobese diabetic mice. J Immunol 181(10):6789-96. [PubMed: 18981096]  [MGI Ref ID J:140949]

Urban JF Jr; Noben-Trauth N; Donaldson DD; Madden KB; Morris SC; Collins M; Finkelman FD. 1998. IL-13, IL-4Ralpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis. Immunity 8(2):255-64. [PubMed: 9492006]  [MGI Ref ID J:110429]

VanLith ML; Kohlgraf KG; Sivinski CL; Tempero RM; Hollingsworth MA. 2002. MUC1-specific anti-tumor responses: molecular requirements for CD4-mediated responses. Int Immunol 14(8):873-82. [PubMed: 12147624]  [MGI Ref ID J:113544]

Verykokakis M; Boos MD; Bendelac A; Kee BL. 2010. SAP protein-dependent natural killer T-like cells regulate the development of CD8(+) T cells with innate lymphocyte characteristics. Immunity 33(2):203-15. [PubMed: 20674402]  [MGI Ref ID J:163924]

Vivien L; Benoist C; Mathis D. 2001. T lymphocytes need IL-7 but not IL-4 or IL-6 to survive in vivo. Int Immunol 13(6):763-8. [PubMed: 11369703]  [MGI Ref ID J:69776]

Vokaer B; Van Rompaey N; Lemaitre PH; Lhomme F; Kubjak C; Benghiat FS; Iwakura Y; Petein M; Field KA; Goldman M; Le Moine A; Charbonnier LM. 2010. Critical role of regulatory T cells in th17-mediated minor antigen-disparate rejection. J Immunol 185(6):3417-25. [PubMed: 20733201]  [MGI Ref ID J:163532]

Vosshenrich CA; Ranson T; Samson SI; Corcuff E; Colucci F; Rosmaraki EE; Di Santo JP. 2005. Roles for common cytokine receptor gamma-chain-dependent cytokines in the generation, differentiation, and maturation of NK cell precursors and peripheral NK cells in vivo. J Immunol 174(3):1213-21. [PubMed: 15661875]  [MGI Ref ID J:96422]

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Wuthrich M; Filutowicz HI; Allen HL; Deepe GS; Klein BS. 2007. V beta1+ J beta1.1+/V alpha2+ J alpha49+ CD4+ T cells mediate resistance against infection with Blastomyces dermatitidis. Infect Immun 75(1):193-200. [PubMed: 17030569]  [MGI Ref ID J:182208]

Wynn TA; Morawetz R; Scharton-Kersten T; Hieny S; Morse HC 3rd ; Kuhn R ; Muller W ; Cheever AW ; Sher A. 1997. Analysis of granuloma formation in double cytokine-deficient mice reveals a central role for IL-10 in polarizing both T helper cell 1- and T helper cell 2-type cytokine responses in vivo. J Immunol 159(10):5014-23. [PubMed: 9366429]  [MGI Ref ID J:44069]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2525.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3283.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

General Supply Notes

Control Information

  Control
   001976 NOD/ShiLtJ
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice
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Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
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Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

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phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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