Strain Name:

CHa.SWV(C3Fe)-Mbpshi/J

Stock Number:

004223

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Availability:

Cryopreserved - Ready for recovery

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Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Congenic; Mutant Strain; Spontaneous Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain BALB/cHa
Donor Strain SWV (Swiss Webster Vancouver)

Appearance
albino, shivering
Related Genotype: A/A Tyrp1b/Tyrp1b Tyrc/Tyrc Mbpshi/Mbpshi

albino, unaffected
Related Genotype: A/A Tyrp1b/Tyrp1b Tyrc/Tyrc Mbpshi/+

Development
The Mbpshi mutation originated on the strain SWV (Swiss Webster Vancouver) and was backcrossed onto the C3HeB/FeJ background. Dorf and his colleagues made the BALB/cHa congenic from the C3H congenic. So the congenic interval containing Mbpshi is derived from SWV, but there may be genetic material from C3H in the BALB/c congenic strain, particularly flanking the original congenic interval.

Control Information

  Control
   001026 BALB/cByJ
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Mbpshi allele
001428   C3Fe.SWV-Mbpshi/J
View Strains carrying   Mbpshi     (1 strain)

Strains carrying other alleles of Mbp
002492   B6.MDB-Mbpshi-mld/J
005226   BALB/cJ-Mbpshi-J/GrsrJ
View Strains carrying other alleles of Mbp     (2 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Mbpshi/Mbp+

        C3Fe.SWV-Mbpshi/J
  • hearing/vestibular/ear phenotype
  • absent linear vestibular evoked potential
    • in one of two mice tested, VESPs are absent at the maximum stimulus intensity used   (MGI Ref ID J:116914)
  • reduced linear vestibular evoked potential
    • elevated threshold and absent central response peaks in aged mice   (MGI Ref ID J:116914)

Mbpshi/Mbpshi

        involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SWV
  • mortality/aging
  • premature death
    • die around 3 months of age   (MGI Ref ID J:38856)
  • nervous system phenotype
  • abnormal myelin sheath morphology
    • when present axon sheaths are thinner than normal and poorly compacted   (MGI Ref ID J:38856)
  • abnormal myelination
    • dysmyelination with many naked axons   (MGI Ref ID J:38856)
  • behavior/neurological phenotype
  • ataxia   (MGI Ref ID J:38856)
  • tremors   (MGI Ref ID J:38856)

Mbpshi/Mbpshi

        C3Fe.SWV-Mbpshi/J
  • hearing/vestibular/ear phenotype
  • reduced linear vestibular evoked potential
    • elevated threshold for aged mice and prolonged latency for central response peaks in young and aged mice   (MGI Ref ID J:116914)
  • immune system phenotype
  • *normal* immune system phenotype
    • T cell, B cell, and macrophage counts are normal   (MGI Ref ID J:41447)
    • decreased susceptibility to viral infection
      • following infection with Theiler's murine encephalomyelitis virus (TMEV), mice exhibit no viral RNA or signs of infection in the spinal cord unlike similarly treated wild-type mice   (MGI Ref ID J:41447)

Mbpshi/Mbpshi

        SWV-Mbpshi
  • mortality/aging
  • premature death
    • mice die between P50 and P100   (MGI Ref ID J:6578)
    • mice on a pure SWV background die sooner than mice on a mixed C3H, ICR, and SWV background   (MGI Ref ID J:6578)
  • reproductive system phenotype
  • *normal* reproductive system phenotype
    • mice are fertile   (MGI Ref ID J:6578)
  • behavior/neurological phenotype
  • abnormal maternal nurturing
    • clinical manifestations interfere with normal mothering   (MGI Ref ID J:6578)
  • abnormal spatial learning
    • in a T-maze, mice exhibit impaired successive reversal learning compared with wild-type mice   (MGI Ref ID J:27482)
  • homeostasis/metabolism phenotype
  • decreased cholesterol level
    • slightly in the sciatic nerve   (MGI Ref ID J:9907)
    • decreased brain cholesterol level   (MGI Ref ID J:9907)
  • nervous system phenotype
  • decreased brain cholesterol level   (MGI Ref ID J:9907)

Mbpshi/Mbpshi

        involves: C3H * ICR * SWV
  • mortality/aging
  • premature death
    • mice die between P50 and P100   (MGI Ref ID J:6578)
    • mice on a mixed C3H, ICR, and SWV background live longer than mice on a pure SWV background   (MGI Ref ID J:6578)
  • nervous system phenotype
  • environmentally induced seizures
    • seizures can be triggered by sound, motion, light, and handling   (MGI Ref ID J:6578)
    • audiogenic seizures   (MGI Ref ID J:6578)
  • tonic seizures
    • from P30   (MGI Ref ID J:6578)
  • behavior/neurological phenotype
  • environmentally induced seizures
    • seizures can be triggered by sound, motion, light, and handling   (MGI Ref ID J:6578)
    • audiogenic seizures   (MGI Ref ID J:6578)
  • hindlimb paralysis
    • on rare occasion with age   (MGI Ref ID J:6578)
  • tonic seizures
    • from P30   (MGI Ref ID J:6578)
  • tremors
    • beginning at 12 days when animals are active   (MGI Ref ID J:6578)

Mbpshi/Mbpshi

        involves: SWV
  • nervous system phenotype
  • abnormal axonal transport
    • increased   (MGI Ref ID J:57128)
  • abnormal myelination
    • mice lack compact myelin unlike wild-type mice   (MGI Ref ID J:57128)
  • abnormal neuron morphology
    • neurons exhibit increased microtubule number and density and neurofilament density compared with wild-type cells   (MGI Ref ID J:57128)
  • behavior/neurological phenotype
  • impaired coordination
    • on a rotarod, mice exhibit impaired coordination compared with wild-type mice   (MGI Ref ID J:127688)
    • however, transgenic expression of Mbp or transplantation of wild-type oligodendrocytes improve performance on a rotarod   (MGI Ref ID J:127688)

Mbpshi/Mbpshi

        involves: BALB/c * C3HeB/Fe * SWV
  • immune system phenotype
  • increased T cell proliferation
    • T cells primed with MBP proliferate in culture unlike wild-type cells   (MGI Ref ID J:48412)
  • increased interferon-gamma secretion
    • when primed with MBP   (MGI Ref ID J:48412)
  • increased interleukin-2 secretion
    • when primed with MBP   (MGI Ref ID J:48412)
  • increased interleukin-4 secretion
    • when primed with MBP   (MGI Ref ID J:48412)
  • increased susceptibility to experimental autoimmune encephalomyelitis
    • following induction of experimental autoimmune encephalomyelitis (EAE), mice develop moderate to severe EAE unlike similarly treated wild-type mice   (MGI Ref ID J:48412)
  • hematopoietic system phenotype
  • increased T cell proliferation
    • T cells primed with MBP proliferate in culture unlike wild-type cells   (MGI Ref ID J:48412)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Mbpshi related

Neurobiology Research
Hearing Defects
Myelination Defects
Tremor Defects

Sensorineural Research
Hearing Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Mbpshi
Allele Name shiverer
Allele Type Spontaneous
Common Name(s) shi;
Strain of OriginSWV
Gene Symbol and Name Mbp, myelin basic protein
Chromosome 18
Gene Common Name(s) C76307; Hmbpr; R75289; expressed sequence C76307; expressed sequence R75289; golli-mbp; hemopoietic myelin basic protein related; mld; myelin deficient; shi; shiverer;
Molecular Note The shiverer mutation involves a large deletion from intron 1 to exon 6. The portion of the gene remaining includes exon 1 and 12.4-14.4 kb of intron 1 sequences. [MGI Ref ID J:20098] [MGI Ref ID J:7748] [MGI Ref ID J:78561] [MGI Ref ID J:7925]

Genotyping

Genotyping Information

Genotyping Protocols

Mbpshi, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Mbpshi related

Abromson-Leeman S; Bronson R; Luo Y; Berman M; Leeman R; Leeman J; Dorf M. 2004. T-cell properties determine disease site, clinical presentation, and cellular pathology of experimental autoimmune encephalomyelitis. Am J Pathol 165(5):1519-33. [PubMed: 15509523]  [MGI Ref ID J:109724]

Atkinson JP; Karp DR; Seeskin EP; Killion CC; Rosa PA; Newell SL; Shreffler DC. 1982. H-2 S region determined polymorphic variants of the C4, Slp, C2, and B complement proteins: a compilation. Immunogenetics 16(6):617-23. [PubMed: 6190740]  [MGI Ref ID J:7096]

Bando Y; Takakusaki K; Ito S; Terayama R; Kashiwayanagi M; Yoshida S. 2008. Differential changes in axonal conduction following CNS demyelination in two mouse models. Eur J Neurosci 28(9):1731-42. [PubMed: 18973589]  [MGI Ref ID J:143243]

Barbarese E; Nielson ML; Carson JH. 1983. The effect of the shiverer mutation on myelin basic protein expression in homozygous and heterozygous mouse brain. J Neurochem 40(6):1680-6. [PubMed: 6189969]  [MGI Ref ID J:7069]

Bihl F; Pena-Rossi C; Guenet JL; Brahic M; Bureau JF. 1997. The shiverer mutation affects the persistence of Theiler's virus in the central nervous system. J Virol 71(7):5025-30. [PubMed: 9188567]  [MGI Ref ID J:41447]

Billings-Gagliardi S; Hall AL; Stanhope GB; Altschuler RJ; Sidman RL; Wolf MK. 1984. Cultures of shiverer mutant cerebellum injected with normal oligodendrocytes make both normal and shiverer myelin. Proc Natl Acad Sci U S A 81(8):2558-61. [PubMed: 6585815]  [MGI Ref ID J:7423]

Billings-Gagliardi S; Nunnari JJ; Wolf MK. 2001. Rumpshaker behaves like juvenile-lethal Plp mutations when combined with shiverer in double mutant mice. Dev Neurosci 23(1):7-16. [PubMed: 11173922]  [MGI Ref ID J:116859]

Bourre JM; Clement M; Gerard D; Chaudiere J. 1989. Alterations of cholesterol synthesis precursors (7-dehydrocholesterol, 7-dehydrodesmosterol, desmosterol) in dysmyelinating neurological mutant mouse (quaking, shiverer and trembler) in the PNS and the CNS. Biochim Biophys Acta 1004(3):387-90. [PubMed: 2547434]  [MGI Ref ID J:9907]

Brady ST; Witt AS; Kirkpatrick LL; de Waegh SM; Readhead C; Tu PH; Lee VM. 1999. Formation of compact myelin is required for maturation of the axonal cytoskeleton. J Neurosci 19(17):7278-88. [PubMed: 10460234]  [MGI Ref ID J:57128]

Bu J; Banki A; Wu Q; Nishiyama A. 2004. Increased NG2(+) glial cell proliferation and oligodendrocyte generation in the hypomyelinating mutant shiverer. Glia 48(1):51-63. [PubMed: 15326615]  [MGI Ref ID J:104811]

Cammer W. 1982. Partial deficiencies in the myelin proteins of developing mice heterozygous for the shiverer mutation. Dev Genet 3:155-163.  [MGI Ref ID J:11954]

Cammer W; Kahn S; Zimmerman T. 1984. Biochemical abnormalities in spinal cord myelin and CNS homogenates in heterozygotes affected by the shiverer mutation. J Neurochem 42(5):1372-8. [PubMed: 6200571]  [MGI Ref ID J:7388]

Campagnoni AT; Campagnoni CW; Bourre JM; Jacque C; Baumann N. 1984. Cell-free synthesis of myelin basic proteins in normal and dysmyelinating mutant mice. J Neurochem 42(3):733-9. [PubMed: 6198470]  [MGI Ref ID J:7310]

Chen H; Cabon F; Sun P; Parmantier E; Dupouey P; Jacque C; Zalc B. 1993. Regional and developmental variations of GFAP and actin mRNA levels in the CNS of jimpy and shiverer mutant mice. J Mol Neurosci 4(2):89-96. [PubMed: 8217522]  [MGI Ref ID J:17936]

Chernoff GF. 1981. Shiverer: an autosomal recessive mutant mouse with myelin deficiency. J Hered 72(2):128. [PubMed: 6168677]  [MGI Ref ID J:6578]

Connor JR; Roskams AJ; Menzies SL; Williams ME. 1993. Transferrin in the central nervous system of the shiverer mouse myelin mutant. J Neurosci Res 36(5):501-7. [PubMed: 7511695]  [MGI Ref ID J:16337]

Dupouey P; Jacque C; Bourre JM; Cesselin F; Privat A; Baumann N. 1979. Immunochemical studies of myelin basic protein in shiverer mouse devoid of major dense line of myelin. Neurosci Lett 12(1):113-8. [PubMed: 88695]  [MGI Ref ID J:6180]

Dyer CA; Phillbotte T; Wolf MK; Billings-Gagliardi S. 1997. Regulation of cytoskeleton by myelin components: studies on shiverer oligodendrocytes carrying an Mbp transgene. Dev Neurosci 19(5):395-409. [PubMed: 9323460]  [MGI Ref ID J:116369]

Edgar JM; McLaughlin M; Werner HB; McCulloch MC; Barrie JA; Brown A; Faichney AB; Snaidero N; Nave KA; Griffiths IR. 2009. Early ultrastructural defects of axons and axon-glia junctions in mice lacking expression of Cnp1. Glia 57(16):1815-24. [PubMed: 19459211]  [MGI Ref ID J:156196]

Edgar JM; McLaughlin M; Yool D; Zhang SC; Fowler JH; Montague P; Barrie JA; McCulloch MC; Duncan ID; Garbern J; Nave KA; Griffiths IR. 2004. Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia. J Cell Biol 166(1):121-31. [PubMed: 15226307]  [MGI Ref ID J:146664]

Frail DE; Braun PE. 1985. Abnormal expression of the myelin-associated glycoprotein in the central nervous system of dysmyelinating mutant mice. J Neurochem 45(4):1071-5. [PubMed: 2411865]  [MGI Ref ID J:7990]

Fujiyoshi T; Hood L; Yoo TJ. 1994. Restoration of brain stem auditory-evoked potentials by gene transfer in shiverer mice. Ann Otol Rhinol Laryngol 103(6):449-56. [PubMed: 7515606]  [MGI Ref ID J:19586]

Gansmuller A; Clerin E; Kruger F; Gumpel M; Lachapelle F. 1991. Tracing transplanted oligodendrocytes during migration and maturation in the shiverer mouse brain. Glia 4(6):580-90. [PubMed: 1720763]  [MGI Ref ID J:857]

Gould RM; Byrd AL; Barbarese E. 1995. The number of Schmidt-Lanterman incisures is more than doubled in shiverer PNS myelin sheaths. J Neurocytol 24(2):85-98. [PubMed: 7745445]  [MGI Ref ID J:27873]

Gout O; Gansmuller A; Baumann N; Gumpel M. 1988. Remyelination by transplanted oligodendrocytes of a demyelinated lesion in the spinal cord of the adult shiverer mouse. Neurosci Lett 87(1-2):195-9. [PubMed: 3380338]  [MGI Ref ID J:27488]

Griffiths I; Klugmann M; Anderson T; Yool D; Thomson C; Schwab MH ; Schneider A ; Zimmermann F ; McCulloch M ; Nadon N ; Nave KA. 1998. Axonal swellings and degeneration in mice lacking the major proteolipid of myelin. Science 280(5369):1610-3. [PubMed: 9616125]  [MGI Ref ID J:48031]

Huseby ES; Liggitt D; Brabb T; Schnabel B; Ohlen C; Goverman J. 2001. A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosis. J Exp Med 194(5):669-76. [PubMed: 11535634]  [MGI Ref ID J:118575]

Huseby ES; Ohlen C; Goverman J. 1999. Cutting edge: myelin basic protein-specific cytotoxic T cell tolerance is maintained in vivo by a single dominant epitope in H-2k mice. J Immunol 163(3):1115-8. [PubMed: 10415003]  [MGI Ref ID J:119201]

Huseby ES; Sather B; Huseby PG; Goverman J. 2001. Age-dependent T cell tolerance and autoimmunity to myelin basic protein. Immunity 14(4):471-81. [PubMed: 11336692]  [MGI Ref ID J:69044]

Inagawa K; Watanabe S; Tsukada Y; Mikoshiba K. 1988. The role of myelination in learning performance observed in two strains of myelin-deficient mutant mice (shiverer and mld). Behav Neural Biol 50(2):184-92. [PubMed: 2465759]  [MGI Ref ID J:27482]

Ioannidou K; Anderson KI; Strachan D; Edgar JM; Barnett SC. 2012. Time-lapse imaging of the dynamics of CNS glial-axonal interactions in vitro and ex vivo. PLoS One 7(1):e30775. [PubMed: 22303455]  [MGI Ref ID J:184214]

Iturria-Medina Y; Perez Fernandez A; Valdes Hernandez P; Garcia Penton L; Canales-Rodriguez EJ; Melie-Garcia L; Castellanos AL; Ortega MO. 2011. Automated discrimination of brain pathological state attending to complex structural brain network properties: the shiverer mutant mouse case. PLoS One 6(5):e19071. [PubMed: 21637753]  [MGI Ref ID J:172715]

Jacque C; Delassalle A; Raoul M; Baumann N. 1983. Myelin basic protein deposition in the optic and sciatic nerves of dysmyelinating mutants quaking, jimpy, Trembler, mld, and shiverer during development. J Neurochem 41(5):1335-40. [PubMed: 6194264]  [MGI Ref ID J:12030]

Ji Q; Perchellet A; Goverman JM. 2010. Viral infection triggers central nervous system autoimmunity via activation of CD8+ T cells expressing dual TCRs. Nat Immunol 11(7):628-34. [PubMed: 20526343]  [MGI Ref ID J:161855]

Jones SM; Johnson KR; Yu H; Erway LC; Alagramam KN; Pollak N; Jones TA. 2005. A quantitative survey of gravity receptor function in mutant mouse strains. J Assoc Res Otolaryngol 6(4):297-310. [PubMed: 16235133]  [MGI Ref ID J:116914]

Kimura M; Inoko H; Katsuki M; Ando A; Sato T; Hirose T; Takashima H; Inayama S; Okano H; Takamatsu K; Mikoshiba K; Tsukada Y; Watanabe I. 1985. Molecular genetic analysis of myelin-deficient mice: shiverer mutant mice show deletion in gene(s) coding for myelin basic protein. J Neurochem 44(3):692-6. [PubMed: 2579195]  [MGI Ref ID J:7748]

Kimura M; Sato M; Akatsuka A; Saito S; Ando K; Yokoyama M; Katsuki M. 1998. Overexpression of a minor component of myelin basic protein isoform (17.2 kDa) can restore myelinogenesis in transgenic shiverer mice. Brain Res 785(2):245-52. [PubMed: 9518636]  [MGI Ref ID J:47182]

Kirkpatrick LL; Witt AS; Payne HR; Shine HD; Brady ST. 2001. Changes in microtubule stability and density in myelin-deficient shiverer mouse CNS axons. J Neurosci 21(7):2288-97. [PubMed: 11264304]  [MGI Ref ID J:68446]

Kirschner DA; Ganser AL. 1980. Compact myelin exists in the absence of basic protein in the shiverer mutant mouse. Nature 283(5743):207-10. [PubMed: 6153124]  [MGI Ref ID J:6244]

Klugmann M; Schwab MH; Puhlhofer A; Schneider A; Zimmermann F ; Griffiths IR ; Nave KA. 1997. Assembly of CNS myelin in the absence of proteolipid protein. Neuron 18(1):59-70. [PubMed: 9010205]  [MGI Ref ID J:38856]

Komiyama A; Suzuki K. 1991. Normal rate of Schwann cell proliferation in the MBP-deficient shiverer mouse during Wallerian degeneration. Brain Res 563(1-2):345-8. [PubMed: 1723925]  [MGI Ref ID J:74]

Kuhn PL; Petroulakis E; Zazanis GA; McKinnon RD. 1995. Motor function analysis of myelin mutant mice using a rotarod. Int J Dev Neurosci 13(7):715-22. [PubMed: 8787862]  [MGI Ref ID J:127688]

Lachapelle F; Duhamel-Clerin E; Gansmuller A; Baron-Van Evercooren A; Villarroya H; Gumpel M. 1994. Transplanted transgenically marked oligodendrocytes survive, migrate and myelinate in the normal mouse brain as they do in the shiverer mouse brain. Eur J Neurosci 6(5):814-24. [PubMed: 8075823]  [MGI Ref ID J:21176]

Lachapelle F; Gumpel M; Baumann N. 1994. Contribution of transplantations to the understanding of the role of the PLP gene. Neurochem Res 19(8):1083-90. [PubMed: 7528353]  [MGI Ref ID J:19842]

Lachapelle F; Lapie P; Campagnoni AT; Gumpel M. 1991. Oligodendrocytes of the jimpy phenotype can be partially restored by environmental factors in vivo. J Neurosci Res 29(2):235-43. [PubMed: 1890702]  [MGI Ref ID J:27477]

Lachapelle F; Lapie P; Gumpel M. 1992. Oligodendrocytes from jimpy and normal mature tissue can be 'activated' when transplanted in a newborn environment. Dev Neurosci 14(2):105-13. [PubMed: 1396170]  [MGI Ref ID J:3029]

Le Goascogne C; Eychenne B; Tonon MC; Lachapelle F; Baumann N; Robel P. 2000. Neurosteroid progesterone is up-regulated in the brain of jimpy and shiverer mice. Glia 29(1):14-24. [PubMed: 10594919]  [MGI Ref ID J:78788]

LeVine SM. 1991. Oligodendrocytes and myelin sheaths in normal, quaking and shiverer brains are enriched in iron. J Neurosci Res 29(3):413-9. [PubMed: 1920537]  [MGI Ref ID J:1932]

Li WX; Kuchler S; Zaepfel M; Badache A; Thomas D; Vincendon G; Baumann N; Zanetta JP. 1993. Cerebellar soluble lectin and its glycoprotein ligands in the developing brain of control and dysmyelinating mutant mice. Neurochem Int 22(2):125-33. [PubMed: 8439766]  [MGI Ref ID J:4577]

Loers G; Aboul-Enein F; Bartsch U; Lassmann H; Schachner M. 2004. Comparison of myelin, axon, lipid, and immunopathology in the central nervous system of differentially myelin-compromised mutant mice: a morphological and biochemical study. Mol Cell Neurosci 27(2):175-89. [PubMed: 15485773]  [MGI Ref ID J:93204]

Martini R; Mohajeri MH; Kasper S; Giese KP; Schachner M. 1995. Mice doubly deficient in the genes for P0 and myelin basic protein show that both proteins contribute to the formation of the major dense line in peripheral nerve myelin. J Neurosci 15(6):4488-95. [PubMed: 7540676]  [MGI Ref ID J:26097]

Marumo T; Takagi Y; Muraki K; Hashimoto N; Miyamoto S; Tanigaki K. 2013. Notch signaling regulates nucleocytoplasmic Olig2 translocation in reactive astrocytes differentiation after ischemic stroke. Neurosci Res 75(3):204-9. [PubMed: 23396245]  [MGI Ref ID J:196605]

Mateu L; Luzzati V; Vonasek E; Borgo M; Lachapelle F. 1996. Order-disorder phenomena in myelinated nerve sheaths. VI. The effects of quaking, jimpy and shiverer mutations: an X-ray scattering study of mouse sciatic and optic nerves. J Mol Biol 256(2):319-29. [PubMed: 8594199]  [MGI Ref ID J:31918]

Mikoshiba K; Takamatsu K; Tsukada Y. 1983. Peripheral nervous system of shiverer mutant mice: developmental change of myelin components and immunohistochemical demonstration of the absence of MBP and presence of P2 protein. Brain Res 283(1):71-9. [PubMed: 6187416]  [MGI Ref ID J:26640]

Molineaux SM; Engh H; de Ferra F; Hudson L; Lazzarini RA. 1986. Recombination within the myelin basic protein gene created the dysmyelinating shiverer mouse mutation. Proc Natl Acad Sci U S A 83(19):7542-6. [PubMed: 2429310]  [MGI Ref ID J:78561]

Montague P; Kirkham D; McCallion AS; Davies RW; Kennedy PG; Klugmann M ; Nave K ; Griffiths IR. 1999. Reduced levels of a specific myelin-associated oligodendrocytic basic protein isoform in shiverer myelin. Dev Neurosci 21(1):36-42. [PubMed: 10077700]  [MGI Ref ID J:54152]

Morishita H; Kawaguchi M; Murata Y; Seiwa C; Hamada S; Asou H; Yagi T. 2004. Myelination triggers local loss of axonal CNR/protocadherin alpha family protein expression. Eur J Neurosci 20(11):2843-7. [PubMed: 15579137]  [MGI Ref ID J:96852]

Nakahara J; Tan-Takeuchi K; Seiwa C; Yagi T; Aiso S; Kawamura K; Asou H. 2001. Myelin basic protein is necessary for the regulation of myelin-associated glycoprotein expression in mouse oligodendroglia. Neurosci Lett 298(3):163-6. [PubMed: 11165432]  [MGI Ref ID J:108036]

Noebels JL; Marcom PK; Jalilian-Tehrani MH. 1991. Sodium channel density in hypomyelinated brain increased by myelin basic protein gene deletion. Nature 352(6334):431-4. [PubMed: 1713650]  [MGI Ref ID J:127054]

Perchellet A; Stromnes I; Pang JM; Goverman J. 2004. CD8+ T cells maintain tolerance to myelin basic protein by 'epitope theft'. Nat Immunol 5(6):606-14. [PubMed: 15146180]  [MGI Ref ID J:90638]

Peterson AC; Bray GM. 1984. Hypomyelination in the peripheral nervous system of shiverer mice and in shiverer in equilibrium normal chimaera. J Comp Neurol 227(3):348-56. [PubMed: 6207210]  [MGI Ref ID J:7591]

Peterson AC; Bray GM. 1984. Normal basal laminas are realized on dystrophic Schwann cells in dystrophic in equilibrium shiverer chimera nerves. J Cell Biol 99(5):1831-7. [PubMed: 6490723]  [MGI Ref ID J:7618]

Pitt D; Gonzales E; Cross AH; Goldberg MP. 2010. Dysmyelinated axons in shiverer mice are highly vulnerable to alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor-mediated toxicity. Brain Res 1309:146-54. [PubMed: 19896473]  [MGI Ref ID J:158545]

Privat A; Jacque C; Bourre JM; Dupouey P; Baumann N. 1979. Absence of the major dense line in myelin of the mutant mouse shiverer. Neurosci Lett 12(1):107-12. [PubMed: 460693]  [MGI Ref ID J:6179]

Rasband MN; Peles E; Trimmer JS; Levinson SR; Lux SE; Shrager P. 1999. Dependence of nodal sodium channel clustering on paranodal axoglial contact in the developing CNS. J Neurosci 19(17):7516-28. [PubMed: 10460258]  [MGI Ref ID J:57130]

Rasband MN; Trimmer JS; Peles E; Levinson SR; Shrager P. 1999. K+ channel distribution and clustering in developing and hypomyelinated axons of the optic nerve. J Neurocytol 28(4-5):319-31. [PubMed: 10739574]  [MGI Ref ID J:121354]

Readhead C; Hood L. 1990. The dysmyelinating mouse mutations shiverer (shi) and myelin deficient (shimld). Behav Genet 20(2):213-34. [PubMed: 1693848]  [MGI Ref ID J:27480]

Readhead C; Popko B; Takahashi N; Shine HD; Saavedra RA; Sidman RL; Hood L. 1987. Expression of a myelin basic protein gene in transgenic shiverer mice: correction of the dysmyelinating phenotype. Cell 48(4):703-12. [PubMed: 2434242]  [MGI Ref ID J:15365]

Roach A; Boylan K; Horvath S; Prusiner SB; Hood LE. 1983. Characterization of cloned cDNA representing rat myelin basic protein: absence of expression in brain of shiverer mutant mice. Cell 34(3):799-806. [PubMed: 6194889]  [MGI Ref ID J:20098]

Roach A; Takahashi N; Pravtcheva D; Ruddle F; Hood L. 1985. Chromosomal mapping of mouse myelin basic protein gene and structure and transcription of the partially deleted gene in shiverer mutant mice. Cell 42(1):149-55. [PubMed: 2410137]  [MGI Ref ID J:7925]

Rosenbluth J. 1980. Central myelin in the mouse mutant shiverer. J Comp Neurol 194(3):639-48. [PubMed: 7451686]  [MGI Ref ID J:6454]

Sadahiro S; Yoshikawa H; Yagi N; Yamamoto Y; Yanagihara T; Kimura M; Sakoda S. 2000. Morphometric analysis of the myelin-associated oligodendrocytic basic protein-deficient mouse reveals a possible role for myelin-associated oligodendrocytic basic protein in regulating axonal diameter. Neuroscience 98(2):361-7. [PubMed: 10854769]  [MGI Ref ID J:119593]

Sharghi-Namini S; Turmaine M; Meier C; Sahni V; Umehara F; Jessen KR; Mirsky R. 2006. The structural and functional integrity of peripheral nerves depends on the glial-derived signal desert hedgehog. J Neurosci 26(23):6364-76. [PubMed: 16763045]  [MGI Ref ID J:109214]

Sheedlo HJ; Siegel GJ. 1987. Comparison of the distribution of Na+,K+-ATPase and myelin-associated glycoprotein (MAG) in the optic nerve, spinal cord and trigeminal ganglion of shiverer (shi/shi) and control (+/+) mice. Brain Res 415(1):105-14. [PubMed: 2441806]  [MGI Ref ID J:27478]

Sheedlo HJ; Siegel GJ; Desmond TJ; Ernst SA. 1987. (Na+ + K+)-adenosinetriphosphatase in the brain of Shiverer (Shi/Shi) mice. Neurochem Res 12(12):1081-6. [PubMed: 2831467]  [MGI Ref ID J:27479]

Shine HD; Readhead C; Popko B; Hood L; Sidman RL. 1992. Morphometric analysis of normal, mutant, and transgenic CNS: correlation of myelin basic protein expression to myelinogenesis. J Neurochem 58(1):342-9. [PubMed: 1370079]  [MGI Ref ID J:1874]

Shine HD; Sidman RL. 1984. Immunoreactive myelin basic proteins are not detected when shiverer mutant Schwann cells and fibroblasts are co-cultured with normal neurons. J Cell Biol 98(4):1291-5. [PubMed: 6201490]  [MGI Ref ID J:7414]

Sinclair A; Raz Y; Kirschner DA; Villa-Komaroff L; Wolf MK; Billings-Gagliardi S. 1991. Shiverer jimpy double mutant mice. V. Correlation of genotype and myelin proteins. Dev Neurosci 13(3):138-42. [PubMed: 1721567]  [MGI Ref ID J:2529]

Smith-Slatas C; Barbarese E. 2000. Myelin basic protein gene dosage effects in the PNS. Mol Cell Neurosci 15(4):343-54. [PubMed: 10845771]  [MGI Ref ID J:123783]

Snaidero N; Mobius W; Czopka T; Hekking LH; Mathisen C; Verkleij D; Goebbels S; Edgar J; Merkler D; Lyons DA; Nave KA; Simons M. 2014. Myelin Membrane Wrapping of CNS Axons by PI(3,4,5)P3-Dependent Polarized Growth at the Inner Tongue. Cell 156(1-2):277-90. [PubMed: 24439382]  [MGI Ref ID J:205563]

Sorg BA; Smith MM; Campagnoni AT. 1987. Developmental expression of the myelin proteolipid protein and basic protein mRNAs in normal and dysmyelinating mutant mice. J Neurochem 49(4):1146-54. [PubMed: 2442307]  [MGI Ref ID J:28225]

Sosa RA; Murphey C; Ji N; Cardona AE; Forsthuber TG. 2013. The kinetics of myelin antigen uptake by myeloid cells in the central nervous system during experimental autoimmune encephalomyelitis. J Immunol 191(12):5848-57. [PubMed: 24227784]  [MGI Ref ID J:207124]

Stoffel W; Boison D; Bussow H. 1997. Functional analysis in vivo of the double mutant mouse deficient in both proteolipid protein (PLP) and myelin basic protein (MBP) in the central nervous system. Cell Tissue Res 289(2):195-206. [PubMed: 9211822]  [MGI Ref ID J:42218]

Tyszka JM; Readhead C; Bearer EL; Pautler RG; Jacobs RE. 2006. Statistical diffusion tensor histology reveals regional dysmyelination effects in the shiverer mouse mutant. Neuroimage 29(4):1058-65. [PubMed: 16213163]  [MGI Ref ID J:112834]

Uschkureit T; Sporkel O; Stracke J; Bussow H; Stoffel W. 2000. Early onset of axonal degeneration in double (plp-/-mag-/-) and hypomyelinosis in triple (plp-/-mbp-/-mag-/-) mutant mice. J Neurosci 20(14):5225-33. [PubMed: 10884306]  [MGI Ref ID J:63480]

Virard I; Coquillat D; Bancila M; Kaing S; Durbec P. 2006. Oligodendrocyte precursor cells generate pituicytes in vivo during neurohypophysis development. Glia 53(3):294-303. [PubMed: 16265670]  [MGI Ref ID J:156148]

Wang H; Allen ML; Grigg JJ; Noebels JL; Tempel BL. 1995. Hypomyelination alters K+ channel expression in mouse mutants shiverer and Trembler. Neuron 15(6):1337-47. [PubMed: 8845157]  [MGI Ref ID J:30245]

Westenbroek RE; Bausch SB; Lin RC; Franck JE; Noebels JL; Catterall WA. 1998. Upregulation of L-type Ca2+ channels in reactive astrocytes after brain injury, hypomyelination, and ischemia. J Neurosci 18(7):2321-34. [PubMed: 9502793]  [MGI Ref ID J:119888]

Westenbroek RE; Noebels JL; Catterall WA. 1992. Elevated expression of type II Na+ channels in hypomyelinated axons of shiverer mouse brain. J Neurosci 12(6):2259-67. [PubMed: 1318958]  [MGI Ref ID J:1153]

Wiktorowicz M; Roach A. 1991. Regulation of myelin basic protein gene transcription in normal and shiverer mutant mice. Dev Neurosci 13(3):143-50. [PubMed: 1721568]  [MGI Ref ID J:2025]

Wolf MK; Nunnari JN; Billings-Gagliardi S. 1999. Quaking*shiverer double-mutant mice survive for at least 100 days with no CNS myelin. Dev Neurosci 21(6):483-90. [PubMed: 10640866]  [MGI Ref ID J:116376]

Wrabetz L; Taveggia C; Feltri ML; Quattrini A; Awatramani R; Scherer SS ; Messing A ; Kamholz J. 1998. A minimal human MBP promoter-lacZ transgene is appropriately regulated in developing brain and after optic enucleation, but not in shiverer mutant mice. J Neurobiol 34(1):10-26. [PubMed: 9469615]  [MGI Ref ID J:45264]

Yandava BD; Billinghurst LL; Snyder EY. 1999. Global cell replacement is feasible via neural stem cell transplantation: evidence from the dysmyelinated shiverer mouse brain. Proc Natl Acad Sci U S A 96(12):7029-34. [PubMed: 10359833]  [MGI Ref ID J:55720]

Yasuda A; Tsuji O; Shibata S; Nori S; Takano M; Kobayashi Y; Takahashi Y; Fujiyoshi K; Hara CM; Miyawaki A; Okano HJ; Toyama Y; Nakamura M; Okano H. 2011. Significance of remyelination by neural stem/progenitor cells transplanted into the injured spinal cord. Stem Cells 29(12):1983-94. [PubMed: 22028197]  [MGI Ref ID J:190194]

Yoshizawa I; Bronson R; Dorf ME; Abromson-Leeman S. 1998. T-cell responses to myelin basic protein in normal and MBP-deficient mice. J Neuroimmunol 84(2):131-8. [PubMed: 9628454]  [MGI Ref ID J:48412]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2525.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $1650.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3283.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $2145.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

General Supply Notes

  • View the complete collection of spontaneous mutants in the Mouse Mutant Resource.

Control Information

  Control
   001026 BALB/cByJ
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice
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JAX® Services
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Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
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Terms of Use

Terms of Use


General Terms and Conditions


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General inquiries regarding Terms of Use

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phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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