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- Description
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- Genes & alleles
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- References
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Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Former Names NOD.Cg-Prkdcscid Tg(RIP E3)1Dvs (Changed: 20-MAY-08 ) NOD.Cg-Prkdcscid TgN(RIP E3)1Dvs (Changed: 15-DEC-04 ) Type Congenic; Spontaneous Mutation; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse H2 Haplotype g7 Generation N5F13+N1p Appearance
albino, pink eyed
Related Genotype: A/A Tyrc/TyrcDevelopment
The Tg(Ins2-E3)1Dvs transgene was introduced into B6D2F2 Oocytes and backcrossed onto C57BL/6J before then being backcrossed onto NOD.CB17-Prkdcscid until N11 and then bred to homozygosity for Prkdcscid and the transgene. This strain is maintained by sibling mating double homozygotes.
Related Strains
Strains carrying Prkdcscid allele
View Strains carrying Prkdcscid (26 strains)
003869 NOD.Cg-Tg(Ins2-E3)1Dvs/DvsJ
004226 NOD/ShiLtDvs-Tg(Ins2-E3*309)5Dvs/DvsJ 004227 NOD/ShiLtDvs-Tg(Ins2-E3*704)2Dvs/DvsJ 004968 NOD/ShiLtDvs-Tg(Ins2-E3*734)3Dvs/DvsJ 004990 NOD/ShiLtDvs-Tg(Ins2-E3*734)4Dvs/DvsJ
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
Prkdcscid relatedResearch Tools
Immunology and Inflammation Research
B and T cell deficiency
Immunology and Inflammation Research
Immunodeficiency
B and T cell deficiency
Internal/Organ Research
Lymphoid Tissue Defects
B and T cell deficiency
Research Tools
Cancer Research
B and T cell deficiency, xenograft/transplant host
Toxicology Research
xenograft/transplant host
Virology Research
B and T Cell Deficiency
AIDS research tool
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Prkdcscid | ||
|---|---|---|---|
| Allele Name | severe combined immunodeficiency | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | scid; | ||
| Strain of Origin | CB17 | ||
| Gene Symbol and Name | Prkdc, protein kinase, DNA activated, catalytic polypeptide | ||
| Chromosome | 16 | ||
| Gene Common Name(s) | AI326420; AU019811; DNA-PK; DNA-PKcs; DNAPDcs; DNAPK; DNPK1; HYRC; HYRC1; MGC189093; XRCC7; expressed sequence AI326420; expressed sequence AU019811; p350; scid; severe combined immunodeficiency; slip; | ||
| Molecular Note | A T-to-A transversion point mutation at a position corresponding to codon 4095 created a premature stop codon. [MGI Ref ID J:35393] [MGI Ref ID J:39329] | ||
| Allele Symbol | Tg(Ins2-E3)1Dvs | ||
| Allele Name | transgene insertion 1, David V Serreze | ||
| Allele Type | Transgenic (random, expressed) | ||
| Strain of Origin | (C57BL/6J x DBA/2J)F2 | ||
| Expressed Gene | E3, adenovirus early region 3, adenovirus | ||
| Promoter | Ins2, insulin 2, rat | ||
| Molecular Note | The adenovirus early region 3 genes, from nucleotide 27752 to 31076, were put under the control of the rat insulin promoter. [MGI Ref ID J:109763] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Prkdcscid, Restriction Enzyme Digest
Helpful Links
Genotyping resources and troubleshooting
References
References
Additional References
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Prkdcscid relatedTg(Ins2-E3)1Dvs relatedAgliano A; Martin-Padura I; Mancuso P; Marighetti P; Rabascio C; Pruneri G; Shultz LD; Bertolini F. 2008. Human acute leukemia cells injected in NOD/LtSz-scid/IL-2Rgamma null mice generate a faster and more efficient disease compared to other NOD/scid-related strains. Int J Cancer 123(9):2222-7. [PubMed: 18688847] [MGI Ref ID J:142410]
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No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. In purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.