Description

Strain Information

Type Coisogenic; Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Mating System Homozygote x Heterozygote         (Female x Male)   08-JAN-08 Mating System Heterozygote x Homozygote         (Female x Male)   08-JAN-08 Species laboratory mouse Generation F14N1F3 (06-NOV-09) Generation Definitions

Control Information

	Control
	000664 C57BL/6J
Considerations for Choosing Controls

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI

      assigned by genotype

sbse/sbse

        C57BL/6J-sbse/J

• craniofacial phenotype
• decreased cranium height   (MGI Ref ID J:128399)
• domed cranium   (MGI Ref ID J:128399)
• short mandible   (MGI Ref ID J:128399)
• short maxilla   (MGI Ref ID J:128399)
• short snout   (MGI Ref ID J:128399)
• small cranium   (MGI Ref ID J:128399)
• small ears   (MGI Ref ID J:128399)
• skeleton phenotype
• decreased bone mineral content
  • whole body bone mineral content is decreased   (MGI Ref ID J:128399)
• decreased bone mineral density
  • whole body bone mineral density is decreased   (MGI Ref ID J:128399)
• decreased cranium height   (MGI Ref ID J:128399)
• domed cranium   (MGI Ref ID J:128399)
• short mandible   (MGI Ref ID J:128399)
• short maxilla   (MGI Ref ID J:128399)
• small cranium   (MGI Ref ID J:128399)
• growth/size phenotype
• decreased body size   (MGI Ref ID J:128399)
• • decreased body weight
    • weight of homozygotes at ages 4, 8, 12, and 16 weeks is approximately 70% that of heterozygous controls   (MGI Ref ID J:128399)
• hearing/vestibular/ear phenotype
• decreased brainstem auditory evoked potential
  • at 7 weeks of age homozygotes have an ABR threshold about 20 db higher than controls, and at 3 months of age it is 30 db higher   (MGI Ref ID J:128399)
• increased susceptibility to age-related hearing loss   (MGI Ref ID J:128399)
• small ears   (MGI Ref ID J:128399)
• reproductive system phenotype
• decreased litter size
  • homozygous females bred with heterozygous males have an average litter size of 4.3 pups, while heterozygous females bred with heterozygous or homozygous males have an average litter size of 5.4 pups   (MGI Ref ID J:128399)
• nervous system phenotype
• hydroencephaly   (MGI Ref ID J:128399)
• adipose tissue phenotype
• decreased percent body fat
  • PIXImus densitometry shows decreased whole body fat   (MGI Ref ID J:128399)
• endocrine/exocrine gland phenotype
• *normal* endocrine/exocrine gland phenotype
  • pituitary assessment found no abnormalities   (MGI Ref ID J:128399)
• vision/eye phenotype
• *normal* vision/eye phenotype
  • eyes are normal by ophthalmoscopic examination at 4 weeks of age   (MGI Ref ID J:128399)

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

sbse related

Developmental Biology Research
Craniofacial and Palate Defects
Growth Defects
Skeletal Defects

Reproductive Biology Research
Fertility Defects

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol		sbse
Allele Name		small body and small ear
Allele Type		Spontaneous
Strain of Origin		C57BL/6J
Gene Symbol and Name		sbse, small body and small ear
Chromosome		4

Genotyping

Genotyping Information

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Curtain MM; Donahue LR. 2007. Small Body and Short Ear Pinna, a Spontaneous Mutation on Chromosome 4 in the Mouse MGI Direct Data Submission :.  [MGI Ref ID J:128399]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           A1

Colony Maintenance

Mating System	Homozygote x Heterozygote         (Female x Male)   08-JAN-08
	Heterozygote x Homozygote         (Female x Male)   08-JAN-08

Purchasing information

Pricing, Supply Level & Notes, Controls

General Supply Notes

• Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

	Control
	000664 C57BL/6J
Considerations for Choosing Controls
Control Pricing Information for Genetically Engineered Mutant Strains.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Ordering Information
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Terms of Use

Terms of Use

General Terms and Conditions

For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries

Contracts Administration

phone:	207-288-6470
fax:	207-288-6655

JAX^® Mice, Products & Services Conditions of Use

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