Description

Strain Information

Type Coisogenic; Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered Mutant Mice. Mating System Homozygote x Heterozygote         (Female x Male) Mating System Heterozygote x Homozygote         (Female x Male) Species laboratory mouse Generation F12 (23-OCT-06)

Control Information

	Control
	000664 C57BL/6J
Considerations for Choosing Controls

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms

      assigned by genotype

sbse/sbse

        C57BL/6J-sbse/J

• craniofacial phenotype
• domed skull (MGI Ref ID J:128399)
• longitudinally short skull (MGI Ref ID J:128399)
• short mandible (MGI Ref ID J:128399)
• short maxilla (MGI Ref ID J:128399)
• short snout (MGI Ref ID J:128399)
• small ears (MGI Ref ID J:128399)
• small skull (MGI Ref ID J:128399)
• skeleton phenotype
• abnormal bone mineralization (MGI Ref ID J:128399)
  • whole body bone mineral density and bone mineral content are decreased
• domed skull (MGI Ref ID J:128399)
• longitudinally short skull (MGI Ref ID J:128399)
• short mandible (MGI Ref ID J:128399)
• short maxilla (MGI Ref ID J:128399)
• small skull (MGI Ref ID J:128399)
• growth/size phenotype
• decreased body size (MGI Ref ID J:128399)
• decreased body weight (MGI Ref ID J:128399)
  • weight of homozygotes at ages 4, 8, 12, and 16 weeks is approximately 70% that of heterozygous controls
• hearing/vestibular/ear phenotype
• decreased brainstem auditory evoked potential (MGI Ref ID J:128399)
  • at 7 weeks of age homozygotes have an ABR threshold about 20 db higher than controls, and at 3 months of age it is 30 db higher
• increased susceptibility to age-related hearing loss (MGI Ref ID J:128399)
• small ears (MGI Ref ID J:128399)
• reproductive system phenotype
• decreased litter size (MGI Ref ID J:128399)
  • homozygous females bred with heterozygous males have an average litter size of 4.3 pups, while heterozygous females bred with heterozygous or homozygous males have an average litter size of 5.4 pups
• nervous system phenotype
• hydroencephaly (MGI Ref ID J:128399)
• adipose tissue phenotype
• decreased percent body fat (MGI Ref ID J:128399)
  • PIXImus densitometry shows decreased whole body fat
• endocrine/exocrine gland phenotype
• *normal* endocrine/exocrine gland phenotype (MGI Ref ID J:128399)
  • pituitary assessment found no abnormalities
• vision/eye phenotype
• *normal* vision/eye phenotype (MGI Ref ID J:128399)
  • eyes are noremal by ophthalmoscopic examination at 4 weeks of age

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

sbse related

Developmental Biology Research
Craniofacial and Palate Defects
Growth Defects
Skeletal Defects

Reproductive Biology Research
Fertility Defects

Genes & Alleles

Gene & Allele Information

Allele Symbol		sbse
Allele Name		small body and small ear
Allele Type		Spontaneous
Strain of Origin		C57BL/6J

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Optimizing PCR Protocols

References

References

Selected Reference(s)

Curtain MM; Donahue LR. 2007. Small Body and Short Ear Pinna, a Spontaneous Mutation on Chromosome 4 in the Mouse MGI Direct Data Submission :.  [MGI Ref ID J:128399]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           A1

Colony Maintenance

Mating System	Homozygote x Heterozygote         (Female x Male)
	Heterozygote x Homozygote         (Female x Male)

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Supply Details

Standard Supply

Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.

Supply Notes

Usually shipped between four and eight weeks of age.

Control Information

	Control
	000664 C57BL/6J
Considerations for Choosing Controls
USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
International - Control Pricing Information for Genetically Engineered Mutant Strains.

General Terms and Conditions

See Terms of Use

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Ordering and Purchasing Information

      Purchasing Information
      JAX^® Mice Orders
      Surgical Services

Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form

Terms of Use

Terms of Use

General Terms and Conditions

Contact information

General inquiries

Contracts Administration

phone:	207-288-6470
fax:	207-288-6655

JAX^® Mice & Services Conditions of Use

“Each recipient institution, including its employees and other researchers under its control (RECIPIENT), of mice or services using mice from The Jackson Laboratory (TJL) agrees that such mice, descendants of those mice derived by inbreeding or crossbreeding, including unmodified derivatives of those mice or their descendants (“MICE”) shall not be: (i) used for any purpose other than the internal research of the RECIPIENT, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services with respect to MICE. Acceptance of MICE from TJL shall be deemed agreement by RECIPIENT to these conditions, and departure from these conditions requires The Jackson Laboratory’s prior written authorization.”

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of MICE, products or services, The Jackson Laboratory will, at its option, provide credit or replacement for the MICE or product received or the services provided.

No Liability

In no event shall The Jackson Laboratory, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, products or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of The Jackson Laboratory, its agents or employees. In purchasing or receiving MICE, products or services from The Jackson Laboratory, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges The Jackson Laboratory from all such causes of action or damages, and further agrees to defend and indemnify The Jackson Laboratory from any costs or damages arising out of any third party claims.

MICE and biological materials are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to The Jackson Laboratory’s MICE, products and services. In addition, special terms and conditions of sale of certain MICE, products and services may be set forth separately in The Jackson Laboratory web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, products and services by The Jackson Laboratory, and by its licensees and distributors.

Acceptance of delivery of MICE, products or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on The Jackson Laboratory, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, products services by The Jackson Laboratory.