Strain Name:

NOD.Cg-H2-Ab1tm1Gru/Dvs

Stock Number:

004256

Availability:

Research Strain

Use Restrictions Apply, see Terms of Use

Description

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered Mutant Mice.
Specieslaboratory mouse
H2 Haplotypeg7
GenerationN10F16 (19-DEC-06)

Appearance
albino, pink eyed
Related Genotype: A/A Tyrc/Tyrc

Development
The H2-Ab1tm1Gru allele was backcrossed from C57BL/6Tac-H2-Ab1tm1Gru TgN(Ab1TL)1Gru (see Stock #002956) onto NOD/Lt.

Related Strains

View Strains carrying   H2-Ab1tm1Gru     (5 strains)

View Strains carrying other alleles of H2-Ab1     (6 strains)

Additional Web Information

Congenic Nomenclature

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms
      assigned by genotype

H2-Ab1tm1Gru/H2-Ab1tm1Gru

        NOD.129S2-H2-Ab1tm1Gru
  • immune system phenotype
  • *normal* immune system phenotype (MGI Ref ID J:86540)
    • NOD mice homozygous for this targeted mutation alone show no indication of inflammation at any age
  • cardiovascular system phenotype
  • *normal* cardiovascular system phenotype (MGI Ref ID J:86540)
    • NOD mice homozygous for this targeted mutation alone show no indication of cardiac enlargement or inflammation at any age
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

H2-Ab1tm1Gru related

Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunodeficiency

Genes & Alleles

Gene & Allele Information

Allele Symbol H2-Ab1tm1Gru
Allele Name targeted mutation 1, Michael J Grusby
Allele Type Targeted (knock-out)
Common Name(s) Ab1tm1Gru; Abb-; Abbtm1; Abeta-; Abetab-; C2-; H2-Ab1-; H2-Ab1tm1Glm; I-Ab-; I-Abetab-; IAb-; IAbeta-; MHC class II-; [KO]Abb; mII-;
Mutation Made By Michael Grusby,   Harvard Medical School
Strain of Origin129S2/SvPas
ES Cell Line NameD3
ES Cell Line Strain129S2/SvPas
Gene Symbol and Name H2-Ab1, histocompatibility 2, class II antigen A, beta 1
Chromosome 17
Gene Common Name(s) A beta; AI845868; Abeta; CELIAC1; H-2Ab; H2-Ab; HLA-DQB; I-Ab; I-Abeta; I-region-associated antigen 2; IAb; IDDM1; Ia-2; Ia2; Rmcs1; expressed sequence AI845868; histocompatibility 2, class II antigen A, beta; response to metastatic cancers 1;
Molecular Note A neomycin selection cassette was inserted into exon 2. In addition, the ES cell line used was derived from the 129S2/SvPas strain, which carries a deletion in the promoter region of H2-Ea. Consequently, these MHC class II molecule-deficient mice lacked cell surface expression of both class II-A and class II-E MHC proteins. [MGI Ref ID J:74418]

Genotyping

Genotyping Information

Genotyping Protocols

H2-Ab1tm1Gru, STD PCR, vers. 1

Helpful Links

Optimizing PCR Protocols

References

References

Additional References

H2-Ab1tm1Gru related

Andersen C; Jensen T; Nansen A; Marker O; Thomsen AR. 1999. CD4(+) T cell-mediated protection against a lethal outcome of systemic infection with vesicular stomatitis virus requires CD40 ligand expression, but not IFN-gamma or IL-4. Int Immunol 11(12):2035-42. [PubMed: 10590269]  [MGI Ref ID J:110491]

Anderson BE; Taylor PA; McNiff JM; Jain D; Demetris AJ; Panoskaltsis-Mortari A; Ager A; Blazar BR; Shlomchik WD; Shlomchik MJ. 2008. Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cells. Blood 111(10):5242-51. [PubMed: 18285547]  [MGI Ref ID J:135662]

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Chapes SK; Mosier DA; Wright AD; Hart ML. 2001. MHCII, Tlr4 and Nramp1 genes control host pulmonary resistance against the opportunistic bacterium Pasteurella pneumotropica. J Leukoc Biol 69(3):381-6. [PubMed: 11261784]  [MGI Ref ID J:69552]

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Chen YT; Kung JT. 2005. CD1d-independent developmental acquisition of prompt IL-4 gene inducibility in thymus CD161(NK1)-CD44lowCD4+CD8- T cells is associated with complementarity determining region 3-diverse and biased Vbeta2/Vbeta7/Vbeta8/Valpha3.2 T cell receptor usage. J Immunol 175(10):6537-50. [PubMed: 16272308]  [MGI Ref ID J:119395]

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Hu HM; Winter H; Ma J; Croft M; Urba WJ; Fox BA. 2002. CD28, TNF receptor, and IL-12 are critical for CD4-independent cross-priming of therapeutic antitumor CD8+ T cells. J Immunol 169(9):4897-904. [PubMed: 12391201]  [MGI Ref ID J:118780]

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Ito K; Bian HJ; Molina M; Han J; Magram J; Saar E; Belunis C; Bolin DR; Arceo R; Campbell R; Falcioni F; Vidovic D; Hammer J; Nagy ZA. 1996. HLA-DR4-IE chimeric class II transgenic, murine class II-deficient mice are susceptible to experimental allergic encephalomyelitis. J Exp Med 183(6):2635-44. [PubMed: 8676084]  [MGI Ref ID J:109908]

Jevnikar AM; Grusby MJ; Glimcher LH. 1994. Prevention of nephritis in major histocompatibility complex class II-deficient MRL-lpr mice. J Exp Med 179(4):1137-43. [PubMed: 7908320]  [MGI Ref ID J:17444]

Keefe R; Dave V; Allman D; Wiest D; Kappes DJ. 1999. Regulation of lineage commitment distinct from positive selection. Science 286(5442):1149-53. [PubMed: 10550051]  [MGI Ref ID J:124533]

Kim EY; Battaile JT; Patel AC; You Y; Agapov E; Grayson MH; Benoit LA; Byers DE; Alevy Y; Tucker J; Swanson S; Tidwell R; Tyner JW; Morton JD; Castro M; Polineni D; Patterson GA; Schwendener RA; Allard JD; Peltz G; Holtzman MJ. 2008. Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease. Nat Med 14(6):633-40. [PubMed: 18488036]  [MGI Ref ID J:136947]

Kim KD; Zhao J; Auh S; Yang X; Du P; Tang H; Fu YX. 2007. Adaptive immune cells temper initial innate responses. Nat Med 13(10):1248-52. [PubMed: 17891146]  [MGI Ref ID J:129989]

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Pricing for International shipping destinations View USA Canada and Mexico pricing
Weeks of AgePrice*GenderGenotypes Provided
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$.00Homozygous for H2-Ab1tm1Gru x Homozygous for H2-Ab1tm1Gru
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Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries

Contracts Administration

phone:207-288-6470
fax:207-288-6655

JAX® Mice & Services Conditions of Use

“Each recipient institution, including its employees and other researchers under its control (RECIPIENT), of mice or services using mice from The Jackson Laboratory (TJL) agrees that such mice, descendants of those mice derived by inbreeding or crossbreeding, including unmodified derivatives of those mice or their descendants (“MICE”) shall not be: (i) used for any purpose other than the internal research of the RECIPIENT, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services with respect to MICE. Acceptance of MICE from TJL shall be deemed agreement by RECIPIENT to these conditions, and departure from these conditions requires The Jackson Laboratory’s prior written authorization.”

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. THE LABORATORY EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of MICE, products or services, The Jackson Laboratory will, at its option, provide credit or replacement for the MICE or product received or the services provided.

No Liability

In no event shall The Jackson Laboratory, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, products or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of The Jackson Laboratory, its agents or employees. In purchasing or receiving MICE, products or services from The Jackson Laboratory, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges The Jackson Laboratory from all such causes of action or damages, and further agrees to defend and indemnify The Jackson Laboratory from any costs or damages arising out of any third party claims.

MICE and biological materials are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to The Jackson Laboratory’s MICE, products and services. In addition, special terms and conditions of sale of certain MICE, products and services may be set forth separately in The Jackson Laboratory web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, products and services by The Jackson Laboratory, and by its licensees and distributors.

Acceptance of delivery of MICE, products or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on The Jackson Laboratory, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, products services by The Jackson Laboratory.


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