Strain Name:

NOD.129S2(B6)-H2-Ab1tm1Gru/DvsJ

Stock Number:

004256

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Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names NOD.129S2-H2-Ab1tm1Gru/Dvs    (Changed: 01-OCT-09 )
NOD.Cg-H2-Ab1tm1Gru/Dvs    (Changed: 29-SEP-09 )
Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
H2 Haplotypeb lacking Ab1
 
Donating InvestigatorDr. David Serreze,   The Jackson Laboratory

Appearance
albino, pink eyed
Related Genotype: A/A Tyrc/Tyrc

Description
NOD/Lt females homozygous for this class II targeted disruption are protected from autoimmune diabetes but develop pancreatitis. They lack peripheral CD4+ T cells but have mature peripheral B cells.

Development
The H2-Ab1tm1Gru allele was backcrossed from B6NTac.Cg-H2-Ab1tm1Gru Tg(Ab1TL)1Gru (see Stock #002956) onto NOD/Lt.

Related Strains

View Strains carrying   H2-Ab1tm1Gru     (7 strains)

View Strains carrying other alleles of H2-Ab1     (9 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

H2-Ab1tm1Gru/H2-Ab1tm1Gru

        NOD.129S2-H2-Ab1tm1Gru
  • immune system phenotype
  • *normal* immune system phenotype
    • NOD mice homozygous for this targeted mutation alone show no indication of inflammation at any age   (MGI Ref ID J:86540)
  • cardiovascular system phenotype
  • *normal* cardiovascular system phenotype
    • NOD mice homozygous for this targeted mutation alone show no indication of cardiac enlargement or inflammation at any age   (MGI Ref ID J:86540)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Diabetes and Obesity Research

Research Tools
Diabetes and Obesity Research

H2-Ab1tm1Gru related

Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunodeficiency

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol H2-Ab1tm1Gru
Allele Name targeted mutation 1, Michael J Grusby
Allele Type Targeted (Null/Knockout)
Common Name(s) Abbeta-; Ab1tm1Gru; Abb-; Abbtm1; Abeta-; Abetab-; C2-; H2-Ab1-; H2-Ab1tm1Glm; I-Ab-; I-Abetab-; IAb-; IAbeta-; MHC class II-; MHC-II-deficient; [KO]Abb; mII-;
Mutation Made ByDr. Michael Grusby,   Harvard Medical School
Strain of Origin129S2/SvPas
ES Cell Line NameD3
ES Cell Line Strain129S2/SvPas
Gene Symbol and Name H2-Ab1, histocompatibility 2, class II antigen A, beta 1
Chromosome 17
Gene Common Name(s) A beta; AI845868; Abeta; Bb; CELIAC1; H-2Ab; H2-Ab; HLA-DQB; I-Ab; I-Abeta; I-region-associated antigen 2; IAb; IDDM1; Ia-2; Ia2; RT1.B; Rmcs1; expressed sequence AI845868; histocompatibility 2, class II antigen A, beta; response to metastatic cancers 1;
General Note Phenotypic Similarity to Human Syndrome: Idiopathic Dilated Cardiomyopathy in double homozygous mice of the strain NOD.Cg-H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell (J:86540)
Molecular Note A neomycin selection cassette was inserted into exon 2. In addition, the ES cell line used was derived from the 129S2/SvPas strain, which carries a deletion in the promoter region of H2-Ea. Consequently, these MHC class II molecule-deficient mice lacked cell surface expression of both class II-A and class II-E MHC proteins. [MGI Ref ID J:74418]

Genotyping

Genotyping Information

Genotyping Protocols

H2-Ab1tm1Grualternate2, Separated PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Serreze DV; Holl TM; Marron MP; Graser RT; Johnson EA; Choisy-Rossi C; Slattery RM; Lieberman SM; DiLorenzo TP. 2004. MHC class II molecules play a role in the selection of autoreactive class I-restricted CD8 T cells that are essential contributors to type 1 diabetes development in nonobese diabetic mice. J Immunol 172(2):871-9. [PubMed: 14707058]  [MGI Ref ID J:87648]

Additional References

Anderson CC; Mukherjee R; Sinclair NR; Jevnikar AM. 1997. Hypogammaglobulinaemia occurs in Fas-deficient MRL-lpr mice following deletion of MHC class II molecules. Clin Exp Immunol 109(3):473-9. [PubMed: 9328125]  [MGI Ref ID J:42959]

Noorchashm H; Lieu YK; Noorchashm N; Rostami SY; Greeley SA; Schlachterman A; Song HK; Noto LE; Jevnikar AM; Barker CF; Naji A. 1999. I-Ag7-mediated antigen presentation by B lymphocytes is critical in overcoming a checkpoint in T cell tolerance to islet beta cells of nonobese diabetic mice. J Immunol 163(2):743-50. [PubMed: 10395666]  [MGI Ref ID J:56160]

H2-Ab1tm1Gru related

Adoro S; McCaughtry T; Erman B; Alag A; Van Laethem F; Park JH; Tai X; Kimura M; Wang L; Grinberg A; Kubo M; Bosselut R; Love P; Singer A. 2011. Coreceptor gene imprinting governs thymocyte lineage fate. EMBO J 31(2):366-77. [PubMed: 22036949]  [MGI Ref ID J:180236]

Alsharifi M; Koskinen A; Wijesundara DK; Bettadapura J; Mullbacher A. 2013. MHC class II-alpha chain knockout mice support increased viral replication that is independent of their lack of MHC class II cell surface expression and associated immune function deficiencies. PLoS One 8(6):e68458. [PubMed: 23840854]  [MGI Ref ID J:204317]

Andersen C; Jensen T; Nansen A; Marker O; Thomsen AR. 1999. CD4(+) T cell-mediated protection against a lethal outcome of systemic infection with vesicular stomatitis virus requires CD40 ligand expression, but not IFN-gamma or IL-4. Int Immunol 11(12):2035-42. [PubMed: 10590269]  [MGI Ref ID J:110491]

Anderson BE; Taylor PA; McNiff JM; Jain D; Demetris AJ; Panoskaltsis-Mortari A; Ager A; Blazar BR; Shlomchik WD; Shlomchik MJ. 2008. Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cells. Blood 111(10):5242-51. [PubMed: 18285547]  [MGI Ref ID J:135662]

Anderson CC; Mukherjee R; Sinclair NR; Jevnikar AM. 1997. Hypogammaglobulinaemia occurs in Fas-deficient MRL-lpr mice following deletion of MHC class II molecules. Clin Exp Immunol 109(3):473-9. [PubMed: 9328125]  [MGI Ref ID J:42959]

Andreasen SO; Christensen JE; Marker O; Thomsen AR. 2000. Role of CD40 ligand and CD28 in induction and maintenance of antiviral CD8+ effector T cell responses. J Immunol 164(7):3689-97. [PubMed: 10725727]  [MGI Ref ID J:123023]

Archambault AS; Carrero JA; Barnett LG; McGee NG; Sim J; Wright JO; Raabe T; Chen P; Ding H; Allenspach EJ; Dragatsis I; Laufer TM; Wu GF. 2013. Cutting edge: Conditional MHC class II expression reveals a limited role for B cell antigen presentation in primary and secondary CD4 T cell responses. J Immunol 191(2):545-50. [PubMed: 23772037]  [MGI Ref ID J:204951]

Arias DA; McCarty N; Lu L; Maldonado RA; Shinohara ML; Cantor H. 2010. Unexpected role of clathrin adaptor AP-1 in MHC-dependent positive selection of T cells. Proc Natl Acad Sci U S A 107(6):2556-61. [PubMed: 20133794]  [MGI Ref ID J:157540]

Arnett HA; Wang Y; Matsushima GK; Suzuki K; Ting JP. 2003. Functional genomic analysis of remyelination reveals importance of inflammation in oligodendrocyte regeneration. J Neurosci 23(30):9824-32. [PubMed: 14586011]  [MGI Ref ID J:88200]

Asada A; Zhao Y; Kondo S; Iwata M. 1998. Induction of thymocyte apoptosis by Ca2+-independent protein kinase C (nPKC) activation and its regulation by calcineurin activation. J Biol Chem 273(43):28392-8. [PubMed: 9774466]  [MGI Ref ID J:115241]

Ashour HM; Niederkorn JY. 2006. Peripheral tolerance via the anterior chamber of the eye: role of B cells in MHC class I and II antigen presentation. J Immunol 176(10):5950-7. [PubMed: 16670303]  [MGI Ref ID J:131707]

Avci FY; Li X; Tsuji M; Kasper DL. 2011. A mechanism for glycoconjugate vaccine activation of the adaptive immune system and its implications for vaccine design. Nat Med 17(12):1602-9. [PubMed: 22101769]  [MGI Ref ID J:179822]

Baccala R; Witherden D; Gonzalez-Quintial R; Dummer W; Surh CD; Havran WL; Theofilopoulos AN. 2005. Gamma delta T cell homeostasis is controlled by IL-7 and IL-15 together with subset-specific factors. J Immunol 174(8):4606-12. [PubMed: 15814683]  [MGI Ref ID J:98166]

Bansal-Pakala P; Halteman BS; Cheng MH; Croft M. 2004. Costimulation of CD8 T cell responses by OX40. J Immunol 172(8):4821-5. [PubMed: 15067059]  [MGI Ref ID J:89135]

Barnett LG; Simkins HM; Barnett BE; Korn LL; Johnson AL; Wherry EJ; Wu GF; Laufer TM. 2014. B cell antigen presentation in the initiation of follicular helper T cell and germinal center differentiation. J Immunol 192(8):3607-17. [PubMed: 24646739]  [MGI Ref ID J:209996]

Belz GT; Stevenson PG; Castrucci MR; Altman JD; Doherty PC. 2000. Postexposure vaccination massively increases the prevalence of gamma-herpesvirus-specific CD8+ T cells but confers minimal survival advantage on CD4-deficient mice. Proc Natl Acad Sci U S A 97(6):2725-30. [PubMed: 10694575]  [MGI Ref ID J:76987]

Belz GT; Wodarz D; Diaz G; Nowak MA; Doherty PC. 2002. Compromised Influenza Virus-Specific CD8(+)-T-Cell Memory in CD4(+)-T-Cell-Deficient Mice. J Virol 76(23):12388-93. [PubMed: 12414983]  [MGI Ref ID J:80033]

Benlagha K; Wei DG; Veiga J; Teyton L; Bendelac A. 2005. Characterization of the early stages of thymic NKT cell development. J Exp Med 202(4):485-92. [PubMed: 16087715]  [MGI Ref ID J:100557]

Bertram EM; Tafuri A; Shahinian A; Chan VS; Hunziker L; Recher M; Ohashi PS; Mak TW; Watts TH. 2002. Role of ICOS versus CD28 in antiviral immunity. Eur J Immunol 32(12):3376-85. [PubMed: 12432568]  [MGI Ref ID J:80851]

Bessa J; Jegerlehner A; Hinton HJ; Pumpens P; Saudan P; Schneider P; Bachmann MF. 2009. Alveolar macrophages and lung dendritic cells sense RNA and drive mucosal IgA responses. J Immunol 183(6):3788-99. [PubMed: 19710454]  [MGI Ref ID J:152307]

Beutner U; McLellan B; Kraus E; Huber BT. 1996. Lack of MMTV superantigen presentation in MHC class II-deficient mice. Cell Immunol 168(2):141-7. [PubMed: 8640859]  [MGI Ref ID J:110738]

Bhattacharya D; Rossi DJ; Bryder D; Weissman IL. 2006. Purified hematopoietic stem cell engraftment of rare niches corrects severe lymphoid deficiencies without host conditioning. J Exp Med 203(1):73-85. [PubMed: 16380511]  [MGI Ref ID J:118834]

Blache C; Adriouch S; Calbo S; Drouot L; Dulauroy S; Arnoult C; Le Corre S; Six A; Seman M; Boyer O. 2009. Cutting edge: CD4-independent development of functional FoxP3+ regulatory t cells. J Immunol 183(7):4182-6. [PubMed: 19767568]  [MGI Ref ID J:152754]

Bonasio R; Scimone ML; Schaerli P; Grabie N; Lichtman AH; von Andrian UH. 2006. Clonal deletion of thymocytes by circulating dendritic cells homing to the thymus. Nat Immunol 7(10):1092-100. [PubMed: 16951687]  [MGI Ref ID J:112629]

Borowski AB; Boesteanu AC; Mueller YM; Carafides C; Topham DJ; Altman JD; Jennings SR; Katsikis PD. 2007. Memory CD8+ T cells require CD28 costimulation. J Immunol 179(10):6494-503. [PubMed: 17982038]  [MGI Ref ID J:153868]

Boucheron N; Tschismarov R; Goeschl L; Moser MA; Lagger S; Sakaguchi S; Winter M; Lenz F; Vitko D; Breitwieser FP; Muller L; Hassan H; Bennett KL; Colinge J; Schreiner W; Egawa T; Taniuchi I; Matthias P; Seiser C; Ellmeier W. 2014. CD4(+) T cell lineage integrity is controlled by the histone deacetylases HDAC1 and HDAC2. Nat Immunol 15(5):439-48. [PubMed: 24681565]  [MGI Ref ID J:209977]

Bowne WB; Srinivasan R; Wolchok JD; Hawkins WG; Blachere NE; Dyall R; Lewis JJ; Houghton AN. 1999. Coupling and uncoupling of tumor immunity and autoimmunity. J Exp Med 190(11):1717-22. [PubMed: 10587362]  [MGI Ref ID J:115120]

Brodeur JF; Li S; Damlaj O; Dave VP. 2009. Expression of fully assembled TCR-CD3 complex on double positive thymocytes: synergistic role for the PRS and ER retention motifs in the intra-cytoplasmic tail of CD3epsilon. Int Immunol 21(12):1317-27. [PubMed: 19819936]  [MGI Ref ID J:155472]

Broussard C; Fleischecker C; Horai R; Chetana M; Venegas AM; Sharp LL; Hedrick SM; Fowlkes BJ; Schwartzberg PL. 2006. Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk. Immunity 25(1):93-104. [PubMed: 16860760]  [MGI Ref ID J:113409]

Broxmeyer HE; Cooper S; Hangoc G; Chang CH. 2006. Class II transactivator-mediated regulation of major histocompatibility complex class II antigen expression is important for hematopoietic progenitor cell suppression by chemokines and iron-binding proteins. Exp Hematol 34(8):1078-84. [PubMed: 16863914]  [MGI Ref ID J:111903]

Byram SC; Carson MJ; DeBoy CA; Serpe CJ; Sanders VM; Jones KJ. 2004. CD4-positive T cell-mediated neuroprotection requires dual compartment antigen presentation. J Neurosci 24(18):4333-9. [PubMed: 15128847]  [MGI Ref ID J:109784]

Byrom B; Barbet AF; Obwolo M; Mahan SM. 2000. CD8(+) T cell knockout mice are less susceptible to Cowdria ruminantium infection than athymic, CD4(+) T cell knockout, and normal C57BL/6 mice. Vet Parasitol 93(2):159-72. [PubMed: 11035234]  [MGI Ref ID J:106232]

Cady CT; Lahn M; Vollmer M; Tsuji M; Seo SJ; Reardon CL; O'Brien RL; Born WK. 2000. Response of murine gamma delta T cells to the synthetic polypeptide poly-Glu50Tyr50. J Immunol 165(4):1790-8. [PubMed: 10925256]  [MGI Ref ID J:120419]

Calderon B; Carrero JA; Miller MJ; Unanue ER. 2011. Cellular and molecular events in the localization of diabetogenic T cells to islets of Langerhans. Proc Natl Acad Sci U S A 108(4):1561-6. [PubMed: 21220322]  [MGI Ref ID J:168246]

Calderon B; Carrero JA; Miller MJ; Unanue ER. 2011. Entry of diabetogenic T cells into islets induces changes that lead to amplification of the cellular response. Proc Natl Acad Sci U S A 108(4):1567-72. [PubMed: 21220309]  [MGI Ref ID J:168247]

Chakkalath HR; Theodos CM; Markowitz JS; Grusby MJ; Glimcher LH; Titus RG. 1995. Class II major histocompatibility complex-deficient mice initially control an infection with Leishmania major but succumb to the disease. J Infect Dis 171(5):1302-8. [PubMed: 7751707]  [MGI Ref ID J:113036]

Chamoto K; Wakita D; Narita Y; Zhang Y; Noguchi D; Ohnishi H; Iguchi T; Sakai T; Ikeda H; Nishimura T. 2006. An essential role of antigen-presenting cell/T-helper type 1 cell-cell interactions in draining lymph node during complete eradication of class II-negative tumor tissue by T-helper type 1 cell therapy. Cancer Res 66(3):1809-17. [PubMed: 16452242]  [MGI Ref ID J:106666]

Chapes SK; Beharka AA. 1998. Salmonella infections in the absence of the major histocompatibility complex II. J Leukoc Biol 63(3):297-304. [PubMed: 9500516]  [MGI Ref ID J:119805]

Chapes SK; Mosier DA; Wright AD; Hart ML. 2001. MHCII, Tlr4 and Nramp1 genes control host pulmonary resistance against the opportunistic bacterium Pasteurella pneumotropica. J Leukoc Biol 69(3):381-6. [PubMed: 11261784]  [MGI Ref ID J:69552]

Chen W; Bennink JR; Morton PA; Yewdell JW. 2002. Mice deficient in perforin, CD4+ T cells, or CD28-mediated signaling maintain the typical immunodominance hierarchies of CD8+ T-cell responses to influenza virus. J Virol 76(20):10332-7. [PubMed: 12239309]  [MGI Ref ID J:126981]

Chen YT; Kung JT. 2005. CD1d-independent developmental acquisition of prompt IL-4 gene inducibility in thymus CD161(NK1)-CD44lowCD4+CD8- T cells is associated with complementarity determining region 3-diverse and biased Vbeta2/Vbeta7/Vbeta8/Valpha3.2 T cell receptor usage. J Immunol 175(10):6537-50. [PubMed: 16272308]  [MGI Ref ID J:119395]

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Chu KK; Tippayawat P; Walker NJ; Harding SV; Atkins HS; Maillere B; Bancroft GJ; Lertmemongkolchai G; Altmann DM. 2011. CD4+ T-cell immunity to the Burkholderia pseudomallei ABC transporter LolC in melioidosis. Eur J Immunol 41(1):107-15. [PubMed: 21182082]  [MGI Ref ID J:174658]

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Erman B; Alag AS; Dahle O; van Laethem F; Sarafova SD; Guinter TI; Sharrow SO; Grinberg A; Love PE; Singer A. 2006. Coreceptor signal strength regulates positive selection but does not determine CD4/CD8 lineage choice in a physiologic in vivo model. J Immunol 177(10):6613-25. [PubMed: 17082573]  [MGI Ref ID J:126026]

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Fowlkes BJ; Robey EA. 2002. A reassessment of the effect of activated Notch1 on CD4 and CD8 T cell development. J Immunol 169(4):1817-21. [PubMed: 12165504]  [MGI Ref ID J:120208]

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Yoshizaki A; Miyagaki T; DiLillo DJ; Matsushita T; Horikawa M; Kountikov EI; Spolski R; Poe JC; Leonard WJ; Tedder TF. 2012. Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions. Nature 491(7423):264-8. [PubMed: 23064231]  [MGI Ref ID J:189218]

Yui MA; Rothenberg EV. 2004. Deranged early T cell development in immunodeficient strains of nonobese diabetic mice. J Immunol 173(9):5381-91. [PubMed: 15494484]  [MGI Ref ID J:132809]

Zhang X; Munegowda MA; Yuan J; Wei Y; Xiang J. 2010. Optimal TLR9 signal converts tolerogenic CD4-8- DCs into immunogenic ones capable of stimulating antitumor immunity via activating CD4+ Th1/Th17 and NK cell responses. J Leukoc Biol 88(2):393-403. [PubMed: 20466823]  [MGI Ref ID J:163943]

Zou YR; Sunshine MJ; Taniuchi I; Hatam F; Killeen N; Littman DR. 2001. Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage. Nat Genet 29(3):332-6. [PubMed: 11687799]  [MGI Ref ID J:130559]

van Meerwijk JP; O'Connell EM; Germain RN. 1995. Evidence for lineage commitment and initiation of positive selection by thymocytes with intermediate surface phenotypes. J Immunol 154(12):6314-23. [PubMed: 7759870]  [MGI Ref ID J:110813]

van Niel G; Wubbolts R; Ten Broeke T; Buschow SI; Ossendorp FA; Melief CJ; Raposo G; van Balkom BW; Stoorvogel W. 2006. Dendritic cells regulate exposure of MHC class II at their plasma membrane by oligoubiquitination. Immunity 25(6):885-94. [PubMed: 17174123]  [MGI Ref ID J:116754]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2525.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $1650.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3283.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $2145.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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