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- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
- Health & care
- References
- Pricing & purchasing
- Terms of use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Type Congenic; Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Background Strain C57BL/6J Generation N11
Generation DefinitionsAppearance
black
Related Genotype: a/a +/+ or a/a Fignfi/+Development
Fidget (fi) was initially described in 1943 by Hans Gruneberg. It arose in an albino strain that Gruneberg described as having been "a pure line at one time"but having been "bred in an uncontrolled manner for some years and probably quite heterogeneous". In 1941 he outcrossed an albino male homozygous for fidget and Tyrc Myo5ad and at to a CBA female from Strong's stock. In 1943 an F2 male was then backcrossed to an albino stock female and the progeny sibling mated for 10 generations at which time, according to Truslove, an outcross was done to "a derivative of the GFF stock which was not highly inbred". Five generations later (1952) it was outcrossed to C57BL. In 1992 Verity Letts at The Jackson Laboratory obtained from Don Varnum in the laboratory of Joseph Nadeau a female mouse called C57BL/6J- Sp/+ fi/fi. Dr. Letts bred out the splotch mutation yielding this strain.
Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Facebase: models
View Facebase: models (58 strains)
000312 STOCK stb + a/+ Fignfi a/J
004276 B6.129-Figntm1Frk/Frk
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Fignfi/Fignfi
involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6
- craniofacial phenotype
- cleft secondary palate
- ~19% of Akap8-sufficient, Fign-deficient mice show cleft palate (MGI Ref ID J:116474)
- digestive/alimentary phenotype
- cleft secondary palate
- ~19% of Akap8-sufficient, Fign-deficient mice show cleft palate (MGI Ref ID J:116474)
Fignfi/Fignfi
involves: 129S1/SvImJ * C57BL/6
- craniofacial phenotype
- cleft secondary palate
- some mice show complete cleft of secondary palate (MGI Ref ID J:116474)
- digestive/alimentary phenotype
- cleft secondary palate
- some mice show complete cleft of secondary palate (MGI Ref ID J:116474)
Fignfi/Fignfi
mixed
- growth/size phenotype
- decreased body weight
- after first 1-2 weeks, mutants weigh ~50% as much as wild-type littermates (MGI Ref ID J:13035)
- postnatal growth retardation
- during the first 1 or 2 weeks after birth, mice exhibit lag in growth (MGI Ref ID J:13035)
- behavior/neurological phenotype
- abnormal locomotor coordination
- abnormal maternal nurturing
- some females produce litters which they fail to rear (MGI Ref ID J:13035)
- bidirectional circling
- animals circle, but behavior is not marked as in other circling mutants such as waltzers (MGI Ref ID J:13035)
- head shaking
- affected mice shake their heads from side to side, from a few times to many times in rapid succession, starting as early as 3-4 days after birth; excursions are small (MGI Ref ID J:13035)
- shaking is most marked when mouse is active and ambulatory; movements tend to decrease when animal is quiet (MGI Ref ID J:13035)
- impaired coordination
- when suspended by the tail, mice exhibit violent jerking movements of their bodies without purposeful coordination (MGI Ref ID J:13035)
- increased startle reflex
- mutants initially display hypersensitivity to sound at 3 weeks of age (MGI Ref ID J:13035)
- hearing/vestibular/ear phenotype
- *normal* hearing/vestibular/ear phenotype
- abnormal membranous labyrinth morphology
- the dorsal part of membranous labyrinth fails to differentiate into normal semicircular canals during embryonic development (MGI Ref ID J:13048)
- absent lateral semicircular canal
- always completely absent (MGI Ref ID J:13048)
- absent semicircular canals
- in may animals (MGI Ref ID J:13048)
- deafness
- increased susceptibility to age-related hearing loss
- immune system phenotype
- eye inflammation
- blisters of the corneal epithelium are present at early ages; these burst and coalesce, sometimes forming large ulcers (MGI Ref ID J:13035)
- conjunctivitis
- after birth once the eyes have opened, discharge from the conjunctiva occurs, such that the eyelids stick together; one or both eyes are closed in affected animals for much of their lives (MGI Ref ID J:13035)
- vision/eye phenotype
- abnormal cornea morphology
- small perforation of the entire thickness of each cornea near its centre in a few mutants (MGI Ref ID J:13048)
- abnormal eye development
- cells in the retinal anlage do not begin transition to differentiated state in general nuclear layer until E12, whereas wild-type cells start transition at E11 (MGI Ref ID J:5736)
- abnormal meibomian gland morphology
- hypertrophy of the Harderian and tarsal glands of the eyelids (MGI Ref ID J:13048)
- abnormal retina morphology
- retina matures more slowly than in wild-type (MGI Ref ID J:5736)
- absent lacrimal glands
- in both newborn and in adults (MGI Ref ID J:13048)
- eye inflammation
- blisters of the corneal epithelium are present at early ages; these burst and coalesce, sometimes forming large ulcers (MGI Ref ID J:13035)
- conjunctivitis
- after birth once the eyes have opened, discharge from the conjunctiva occurs, such that the eyelids stick together; one or both eyes are closed in affected animals for much of their lives (MGI Ref ID J:13035)
- microphthalmia
- much reduced eyes from the age of 13 days onward (MGI Ref ID J:13048)
- small lens
- limbs/digits/tail phenotype
- fused tarsal bones
- significantly higher incidence of tarsal fusions (MGI Ref ID J:13048)
- polydactyly
- usually involving first digit of hindlimbs, observed in small subset of animals (MGI Ref ID J:13035)
- occasionally only doubling of distal pad of toe, with or without claw occurs; in some cases, extra toe is completely separated from original and larger in size (MGI Ref ID J:13035)
- doubling of digits tends to disappear with growth (MGI Ref ID J:13035)
- reproductive system phenotype
- reduced fertility
- females are sometimes sterile while others show reduced fertility (MGI Ref ID J:13035)
- cellular phenotype
- abnormal cell cycle
- generation time (T) of retinal cells is longer (20 hours) than in wild-type (18 hours); cell cycle duration is increased 2 hours in mutants (MGI Ref ID J:5736)
- duration of S phase is 8.5 hours compared to 9.75 in wild-type; M phase is shorter (8.5 hours) than in wild-type (9.25 hours (MGI Ref ID J:5736)
- craniofacial phenotype
- abnormal craniofacial bone morphology
- missing the subarcuate fossa and the fenestra flocculi in the auditory capsule (MGI Ref ID J:13048)
- decreased size of the pterygoid process and the incidence of the foramen sphenoidale medium (MGI Ref ID J:13048)
- presphenoid-basisphenoid fusion in some (MGI Ref ID J:13048)
- parieto-squamosal fusion in some (MGI Ref ID J:13048)
- interfrontal-frontal fusion in some (MGI Ref ID J:13048)
- abnormal mandible morphology
- some mutants show a complete absence of the mandibular and mental foramina and hence of the mandibular canal (MGI Ref ID J:13048)
- skeleton phenotype
- abnormal craniofacial bone morphology
- missing the subarcuate fossa and the fenestra flocculi in the auditory capsule (MGI Ref ID J:13048)
- decreased size of the pterygoid process and the incidence of the foramen sphenoidale medium (MGI Ref ID J:13048)
- presphenoid-basisphenoid fusion in some (MGI Ref ID J:13048)
- parieto-squamosal fusion in some (MGI Ref ID J:13048)
- interfrontal-frontal fusion in some (MGI Ref ID J:13048)
- abnormal mandible morphology
- some mutants show a complete absence of the mandibular and mental foramina and hence of the mandibular canal (MGI Ref ID J:13048)
- abnormal pelvic girdle bone morphology
- fused tarsal bones
- significantly higher incidence of tarsal fusions (MGI Ref ID J:13048)
- nervous system phenotype
- abnormal cerebellar lobule formation
- endocrine/exocrine gland phenotype
- abnormal Harderian gland morphology
- hypertrophy of the Harderian and tarsal glands of the eyelids (MGI Ref ID J:13048)
- abnormal meibomian gland morphology
- hypertrophy of the Harderian and tarsal glands of the eyelids (MGI Ref ID J:13048)
- absent lacrimal glands
- in both newborn and in adults (MGI Ref ID J:13048)
- cardiovascular system phenotype
- corneal vascularization
- occurs in later stages of inflammation (MGI Ref ID J:13035)
- integument phenotype
- abnormal meibomian gland morphology
- hypertrophy of the Harderian and tarsal glands of the eyelids (MGI Ref ID J:13048)
This mouse can be used to support research in many areas including:Fignfi related
Developmental Biology Research
Neurodevelopmental Defects
Skeletal Defects
Neurobiology Research
Hearing Defects
Neurodevelopmental Defects
Vestibular Defects
Sensorineural Research
Cataracts
nuclear
Eye Defects
Hearing Defects
Vestibular Defects
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Fignfi | ||
|---|---|---|---|
| Allele Name | fidget | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | fi; | ||
| Strain of Origin | random-bred | ||
| Gene Symbol and Name | Fign, fidgetin | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | fi; fidget; | ||
| Molecular Note | The fidget mutation is due to a retrotransposon insertion in intron 2, interfering with normal RNA processing. [MGI Ref ID J:64964] | ||
References
References provided by MGI
Additional References
Cox GA; Mahaffey CL; Nystuen A; Letts VA; Frankel WN. 2000. The mouse fidgetin gene defines a new role for AAA family proteins in mammalian development Nat Genet 26(2):198-202. [PubMed: 11017077] [MGI Ref ID J:64964]
Konyukhov BV; Sazhina MV. 1976. The cell cycle and retinal histogenesis fidget mutant mice. Dev Biol 54(1):13-22. [PubMed: 1001817] [MGI Ref ID J:5736]
Fignfi relatedBodmer WF. 1961. Viability effects and recombination differences in a linkage test with pallid and fidget in the house mouse Heredity 16:485-95. [MGI Ref ID J:2]
CARTER TC; GRUNEBERG H. 1950. Linkage between fidget and agouti in the house mouse. Heredity 4(3):373-6. [PubMed: 14802993] [MGI Ref ID J:85]
Cox GA; Mahaffey CL; Nystuen A; Letts VA; Frankel WN. 2000. The mouse fidgetin gene defines a new role for AAA family proteins in mammalian development Nat Genet 26(2):198-202. [PubMed: 11017077] [MGI Ref ID J:64964]
Deol MS. 1976. Deficiencies of the inner ear in the mouse and their origin Colloq Int (Collques Internationaux) C.N.R.S. 266:163-171. [MGI Ref ID J:136112]
Gruneberg H. 1971. Exocrine glands and the Chievitz organ of some mouse mutants. J Embryol Exp Morphol 25(2):247-61. [PubMed: 5088022] [MGI Ref ID J:140462]
Gruneberg H. 1943. Two new mutant genes in the house mouse. J Genet 45:22-28. [MGI Ref ID J:13035]
Iakovlev MI; Platonov ES; Koniukhov BV. 1977. [Influence of mutant genes on crystallin synthesis in the forming mouse lens. II. Fidget and ocular retardation genes] Ontogenez 8(2):115-20. [PubMed: 904847] [MGI Ref ID J:30777]
Johnson DR. 1976. The interfrontal bone and mutant genes in the mouse. J Anat 121(3):507-13. [PubMed: 1018005] [MGI Ref ID J:5776]
Konyukhov BV; Mironova OV. 1979. Interaction of the mutant genes splotch and fidget in mice. Sov Genet 15:407-411. [MGI Ref ID J:11996]
Konyukhov BV; Sazhina MV. 1976. The cell cycle and retinal histogenesis fidget mutant mice. Dev Biol 54(1):13-22. [PubMed: 1001817] [MGI Ref ID J:5736]
Konyukhov BV; Wachtel AW. 1963. Electrophoretic studies of proteins in normal lenses and cataracts of inbred and mutant mice Exp Eye Res 2:325-30. [PubMed: 14073604] [MGI Ref ID J:268]
Nadeau JH. 2001. Modifier genes in mice and humans. Nat Rev Genet 2(3):165-74. [PubMed: 11256068] [MGI Ref ID J:88013]
Stubbs L; Huxley C; Hogan B; Evans T; Fried M; Duboule D; Lehrach H. 1990. The HOX-5 and surfeit gene clusters are linked in the proximal portion of mouse chromosome 2. Genomics 6(4):645-50. [PubMed: 1971250] [MGI Ref ID J:10508]
Truslove GM. 1956. The anatomy and development of the fidget mouse. J Genet 54:64-86. [MGI Ref ID J:13048]
Wallace ME. 1976. Hydronephrosis in the mouse: the effects of the short-ear gene, sex and ureteral vascular system. Am J Anat 147(1):1932. [PubMed: 970345] [MGI Ref ID J:5695]
Yang Y; Mahaffey CL; Berube N; Frankel WN. 2006. Interaction between fidgetin and protein kinase A-anchoring protein AKAP95 is critical for palatogenesis in the mouse. J Biol Chem 281(31):22352-9. [PubMed: 16751186] [MGI Ref ID J:116474]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
|
Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $3000.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
- Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
| Pricing for International shipping destinations |
|
Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $3900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
- Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
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Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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