Strain Name:

B6.Cg-Fignfi/Frk

Stock Number:

004275

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Availability:

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Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Congenic; Mutant Strain;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain C57BL/6J

Appearance
black
Related Genotype: a/a +/+ or a/a Fignfi/+

Development
Fidget (fi) was initially described in 1943 by Hans Gruneberg. It arose in an albino strain that Gruneberg described as having been "a pure line at one time"but having been "bred in an uncontrolled manner for some years and probably quite heterogeneous". In 1941 he outcrossed an albino male homozygous for fidget and Tyrc Myo5ad and at to a CBA female from Strong's stock. In 1943 an F2 male was then backcrossed to an albino stock female and the progeny sibling mated for 10 generations at which time, according to Truslove, an outcross was done to "a derivative of the GFF stock which was not highly inbred". Five generations later (1952) it was outcrossed to C57BL. In 1992 Verity Letts at The Jackson Laboratory obtained from Don Varnum in the laboratory of Joseph Nadeau a female mouse called C57BL/6J- Sp/+ fi/fi. Dr. Letts bred out the splotch mutation yielding this strain.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Facebase: models
007664   129S-Efnb1tm1Sor/J
000646   A/J
000647   A/WySnJ
005709   B6.129-Skitm1Cco/J
002619   B6.129-Tgfb3tm1Doe/J
007453   B6.129P2(Cg)-Dhcr7tm1Gst/J
010525   B6.129S-Notch2tm3Grid/J
010616   B6.129S1-Jag1tm1Grid/J
010546   B6.129S1-Jag2tm1Grid/J
010620   B6.129S1-Notch2tm1Grid/J
009387   B6.129S1-Osr1tm1Jian/J
009386   B6.129S1-Osr2tm1Jian/J
010621   B6.129S1-Snai1tm2.1Grid/J
010617   B6.129S1-Snai2tm1Grid/J
003865   B6.129S2-Itgavtm1Hyn/J
003755   B6.129S4-Meox2tm1(cre)Sor/J
016902   B6.129S5-Irf6Gt(OST398253)Lex/J
003336   B6.129S7-Cdkn1ctm1Sje/J
012843   B6.129X1(Cg)-Slc32a1tm1.1Bgc/J
000026   B6.C3-Gli3Xt-J/J
012844   B6.Cg-Gad1tm1.1Bgc/J
006382   B6;129-Casktm1Sud/J
002711   B6;129-Gabrb3tm1Geh/J
004293   B6;129-Shhtm2Amc/J
012603   B6;129-Tgfbr2tm1Karl/J
010618   B6;129S-Jag1tm2Grid/J
010686   B6;129S-Snai1tm2Grid/J
009389   B6;129S1-Bambitm1Jian/J
010619   B6;129S1-Lfngtm1Grid/J
010547   B6;129S1-Notch3tm1Grid/J
010544   B6;129S1-Notch4tm1Grid/J
010722   B6;129S1-Snai2tm2Grid/J
012463   B6;129S4-Foxd1tm1(GFP/cre)Amc/J
022358   B6;129S6-Rr23tm1Axvi/Mmjax
022359   B6;129S6-Rr24tm1Axvi/Mmjax
022360   B6;129S6-Rr25tm1Axvi/Mmjax
003277   B6;129S7-Acvr2atm1Zuk/J
002788   B6;129S7-Fsttm1Zuk/J
002990   B6;129S7-Inhbatm1Zuk/J
000523   B6By.Cg-Eh/J
000278   B6C3Fe a/a-Papss2bm Hps1ep Hps6ru/J
000515   B6CBACa Aw-J/A-SfnEr/J
001434   C3HeB/FeJ x STX/Le-Mc1rE-so Gli3Xt-J Zeb1Tw/J
000252   DC/LeJ
005057   FVB.129-Kcnj2tm1Swz/J
012655   FVB.A-Irf6clft1/BeiJ
013100   FVB.C-Prdm16csp1/J
017437   FVB/N-Ckap5TgTn(sb-cHS4,Tyr)2320F-1Ove/J
017438   FVB/N-MidnTg(Tyr)2261EOve/J
017609   FVB/N-Rr16Tn(sb-Tyr)1HCebOve/J
017598   FVB/N-Sdccag8Tn(sb-Tyr)2161B.CA1C2Ove/J
017608   FVB/N-Skor2Tn(sb-Tyr)1799B.CA7BOve/J
017436   FVB/N-Tapt1TgTn(sb-cHS4,Tyr)2508GOve/J
016870   FVB/NJ-Ap2b1Tg(Tyr)427Ove/EtevJ
017434   FVB;B6-Cramp1lTgTn(sb-rtTA,Tyr)2447AOve/J
017594   FVB;B6-Eya4TgTn(Prm1-sb10,sb-Tyr)1739AOve/J
017435   FVB;B6-SlmapTn(sb-rtTA)2426B.SB4Ove/J
003318   STOCK Shhtm1Amc/J
003102   STOCK Tgfb2tm1Doe/J
018624   STOCK Tgfb3tm2(Tgfb1)Vk/J
008469   STOCK Wnt9btm1.2Amc/J
View Facebase: models     (61 strains)

Strains carrying   Fignfi allele
000312   STOCK stb + a/+ Fignfi a/J
View Strains carrying   Fignfi     (1 strain)

Strains carrying other alleles of Fign
004276   B6.129-Figntm1Frk/Frk
View Strains carrying other alleles of Fign     (1 strain)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Fignfi/Fignfi

        involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6
  • craniofacial phenotype
  • cleft secondary palate
    • ~19% of Akap8-sufficient, Fign-deficient mice show cleft palate   (MGI Ref ID J:116474)
  • digestive/alimentary phenotype
  • cleft secondary palate
    • ~19% of Akap8-sufficient, Fign-deficient mice show cleft palate   (MGI Ref ID J:116474)

Fignfi/Fignfi

        involves: 129S1/SvImJ * C57BL/6
  • craniofacial phenotype
  • cleft secondary palate
    • some mice show complete cleft of secondary palate   (MGI Ref ID J:116474)
  • digestive/alimentary phenotype
  • cleft secondary palate
    • some mice show complete cleft of secondary palate   (MGI Ref ID J:116474)

Fignfi/Fignfi

        mixed
  • growth/size/body phenotype
  • decreased body weight
    • after first 1-2 weeks, mutants weigh ~50% as much as wild-type littermates   (MGI Ref ID J:13035)
  • postnatal growth retardation
    • during the first 1 or 2 weeks after birth, mice exhibit lag in growth   (MGI Ref ID J:13035)
  • behavior/neurological phenotype
  • abnormal locomotor coordination
    • when suspended by the tail, mice exhibit violent jerking movements of their bodies without purposeful coordination   (MGI Ref ID J:13035)
    • when placed in water, mice appear to lose all sense of direction and begin to gyrate frantically   (MGI Ref ID J:13035)
  • abnormal maternal nurturing
    • some females produce litters which they fail to rear   (MGI Ref ID J:13035)
  • bidirectional circling
    • animals circle, but behavior is not marked as in other circling mutants such as waltzers   (MGI Ref ID J:13035)
  • head shaking
    • affected mice shake their heads from side to side, from a few times to many times in rapid succession, starting as early as 3-4 days after birth; excursions are small   (MGI Ref ID J:13035)
    • shaking is most marked when mouse is active and ambulatory; movements tend to decrease when animal is quiet   (MGI Ref ID J:13035)
  • impaired coordination
    • when suspended by the tail, mice exhibit violent jerking movements of their bodies without purposeful coordination   (MGI Ref ID J:13035)
  • increased startle reflex
    • mutants initially display hypersensitivity to sound at 3 weeks of age   (MGI Ref ID J:13035)
  • hearing/vestibular/ear phenotype
  • *normal* hearing/vestibular/ear phenotype
    • the cochlea appears normal   (MGI Ref ID J:13048)
    • do not turn deaf in old age   (MGI Ref ID J:13048)
    • abnormal membranous labyrinth morphology
      • the dorsal part of membranous labyrinth fails to differentiate into normal semicircular canals during embryonic development   (MGI Ref ID J:13048)
    • absent lateral semicircular canal
      • always completely absent   (MGI Ref ID J:13048)
    • absent semicircular canals
      • in may animals   (MGI Ref ID J:13048)
    • deafness
      • from 3-4 months of age, mice have severe hearing loss or are completely deaf   (MGI Ref ID J:13035)
      • in subsequent analysis, it was shown that an auditory response could be elicited even in very old mutant mice   (MGI Ref ID J:13048)
    • increased susceptibility to age-related hearing loss
      • mutants initially display hypersensitivity to sound at 3 weeks of age, but this is followed by a period where they respond to only drastic stimuli   (MGI Ref ID J:13035)
      • from 3-4 months of age onward, no response to auditory stimuli is observed   (MGI Ref ID J:13035)
  • immune system phenotype
  • eye inflammation
    • blisters of the corneal epithelium are present at early ages; these burst and coalesce, sometimes forming large ulcers   (MGI Ref ID J:13035)
    • conjunctivitis
      • after birth once the eyes have opened, discharge from the conjunctiva occurs, such that the eyelids stick together; one or both eyes are closed in affected animals for much of their lives   (MGI Ref ID J:13035)
  • vision/eye phenotype
  • abnormal cornea morphology
    • small perforation of the entire thickness of each cornea near its centre in a few mutants   (MGI Ref ID J:13048)
    • corneal opacity
      • occurs in later stages, sometimes covering cornea completely   (MGI Ref ID J:13035)
    • corneal vascularization
      • occurs in later stages of inflammation   (MGI Ref ID J:13035)
  • abnormal eye development
    • cells in the retinal anlage do not begin transition to differentiated state in general nuclear layer until E12, whereas wild-type cells start transition at E11   (MGI Ref ID J:5736)
  • abnormal meibomian gland morphology
    • hypertrophy of the Harderian and tarsal glands of the eyelids   (MGI Ref ID J:13048)
  • abnormal retina morphology
    • retina matures more slowly than in wild-type   (MGI Ref ID J:5736)
  • absent lacrimal glands
    • in both newborn and in adults   (MGI Ref ID J:13048)
  • eye inflammation
    • blisters of the corneal epithelium are present at early ages; these burst and coalesce, sometimes forming large ulcers   (MGI Ref ID J:13035)
    • conjunctivitis
      • after birth once the eyes have opened, discharge from the conjunctiva occurs, such that the eyelids stick together; one or both eyes are closed in affected animals for much of their lives   (MGI Ref ID J:13035)
  • microphthalmia
    • much reduced eyes from the age of 13 days onward   (MGI Ref ID J:13048)
  • small lens
    • reduced in size from early stages of embryogenesis   (MGI Ref ID J:13048)
    • approximately 80% of the normal size in length   (MGI Ref ID J:13048)
  • limbs/digits/tail phenotype
  • fused tarsal bones
    • significantly higher incidence of tarsal fusions   (MGI Ref ID J:13048)
  • polydactyly
    • usually involving first digit of hindlimbs, observed in small subset of animals   (MGI Ref ID J:13035)
    • occasionally only doubling of distal pad of toe, with or without claw occurs; in some cases, extra toe is completely separated from original and larger in size   (MGI Ref ID J:13035)
    • doubling of digits tends to disappear with growth   (MGI Ref ID J:13035)
  • reproductive system phenotype
  • reduced fertility
    • females are sometimes sterile while others show reduced fertility   (MGI Ref ID J:13035)
  • cellular phenotype
  • abnormal cell cycle
    • generation time (T) of retinal cells is longer (20 hours) than in wild-type (18 hours); cell cycle duration is increased 2 hours in mutants   (MGI Ref ID J:5736)
    • duration of S phase is 8.5 hours compared to 9.75 in wild-type; M phase is shorter (8.5 hours) than in wild-type (9.25 hours   (MGI Ref ID J:5736)
  • craniofacial phenotype
  • abnormal craniofacial bone morphology
    • missing the subarcuate fossa and the fenestra flocculi in the auditory capsule   (MGI Ref ID J:13048)
    • decreased size of the pterygoid process and the incidence of the foramen sphenoidale medium   (MGI Ref ID J:13048)
    • presphenoid-basisphenoid fusion in some   (MGI Ref ID J:13048)
    • parieto-squamosal fusion in some   (MGI Ref ID J:13048)
    • interfrontal-frontal fusion in some   (MGI Ref ID J:13048)
    • abnormal mandible morphology
      • some mutants show a complete absence of the mandibular and mental foramina and hence of the mandibular canal   (MGI Ref ID J:13048)
  • skeleton phenotype
  • abnormal craniofacial bone morphology
    • missing the subarcuate fossa and the fenestra flocculi in the auditory capsule   (MGI Ref ID J:13048)
    • decreased size of the pterygoid process and the incidence of the foramen sphenoidale medium   (MGI Ref ID J:13048)
    • presphenoid-basisphenoid fusion in some   (MGI Ref ID J:13048)
    • parieto-squamosal fusion in some   (MGI Ref ID J:13048)
    • interfrontal-frontal fusion in some   (MGI Ref ID J:13048)
    • abnormal mandible morphology
      • some mutants show a complete absence of the mandibular and mental foramina and hence of the mandibular canal   (MGI Ref ID J:13048)
  • abnormal pelvic girdle bone morphology
    • considerably reduced anterior iliac spine   (MGI Ref ID J:13048)
    • a decrease in the depth and in the diameter of the fossa acetabuli   (MGI Ref ID J:13048)
    • in some mutant mice of GFF background had a complete dislocation of the hip   (MGI Ref ID J:13048)
  • fused tarsal bones
    • significantly higher incidence of tarsal fusions   (MGI Ref ID J:13048)
  • nervous system phenotype
  • abnormal cerebellar lobule formation
    • the parafloccular lobe of the cerebellum becomes very abnormal in shape   (MGI Ref ID J:13048)
    • no subarcuate fossa   (MGI Ref ID J:13048)
  • endocrine/exocrine gland phenotype
  • abnormal Harderian gland morphology
    • hypertrophy of the Harderian and tarsal glands of the eyelids   (MGI Ref ID J:13048)
  • abnormal meibomian gland morphology
    • hypertrophy of the Harderian and tarsal glands of the eyelids   (MGI Ref ID J:13048)
  • absent lacrimal glands
    • in both newborn and in adults   (MGI Ref ID J:13048)
  • cardiovascular system phenotype
  • corneal vascularization
    • occurs in later stages of inflammation   (MGI Ref ID J:13035)
  • integument phenotype
  • abnormal meibomian gland morphology
    • hypertrophy of the Harderian and tarsal glands of the eyelids   (MGI Ref ID J:13048)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Fignfi related

Developmental Biology Research
Neurodevelopmental Defects
Skeletal Defects

Neurobiology Research
Hearing Defects
Neurodevelopmental Defects
Vestibular Defects

Sensorineural Research
Cataracts
      nuclear
Eye Defects
Hearing Defects
Vestibular Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Fignfi
Allele Name fidget
Allele Type Spontaneous
Common Name(s) fi;
Strain of Originrandom-bred
Gene Symbol and Name Fign, fidgetin
Chromosome 2
Gene Common Name(s) fi; fidget;
Molecular Note The fidget mutation is due to a retrotransposon insertion in intron 2, interfering with normal RNA processing. [MGI Ref ID J:64964]

Genotyping

Genotyping Information

Genotyping Protocols

Fignfi,

MELT



Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Cox GA; Mahaffey CL; Nystuen A; Letts VA; Frankel WN. 2000. The mouse fidgetin gene defines a new role for AAA family proteins in mammalian development Nat Genet 26(2):198-202. [PubMed: 11017077]  [MGI Ref ID J:64964]

Konyukhov BV; Sazhina MV. 1976. The cell cycle and retinal histogenesis fidget mutant mice. Dev Biol 54(1):13-22. [PubMed: 1001817]  [MGI Ref ID J:5736]

Fignfi related

Bodmer WF. 1961. Viability effects and recombination differences in a linkage test with pallid and fidget in the house mouse Heredity 16:485-95.  [MGI Ref ID J:2]

CARTER TC; GRUNEBERG H. 1950. Linkage between fidget and agouti in the house mouse. Heredity 4(3):373-6. [PubMed: 14802993]  [MGI Ref ID J:85]

Cox GA; Mahaffey CL; Nystuen A; Letts VA; Frankel WN. 2000. The mouse fidgetin gene defines a new role for AAA family proteins in mammalian development Nat Genet 26(2):198-202. [PubMed: 11017077]  [MGI Ref ID J:64964]

Deol MS. 1976. Deficiencies of the inner ear in the mouse and their origin Colloq Int (Collques Internationaux) C.N.R.S. 266:163-171.  [MGI Ref ID J:136112]

Gruneberg H. 1971. Exocrine glands and the Chievitz organ of some mouse mutants. J Embryol Exp Morphol 25(2):247-61. [PubMed: 5088022]  [MGI Ref ID J:140462]

Gruneberg H. 1943. Two new mutant genes in the house mouse. J Genet 45:22-28.  [MGI Ref ID J:13035]

Iakovlev MI; Platonov ES; Koniukhov BV. 1977. [Influence of mutant genes on crystallin synthesis in the forming mouse lens. II. Fidget and ocular retardation genes] Ontogenez 8(2):115-20. [PubMed: 904847]  [MGI Ref ID J:30777]

Johnson DR. 1976. The interfrontal bone and mutant genes in the mouse. J Anat 121(3):507-13. [PubMed: 1018005]  [MGI Ref ID J:5776]

Konyukhov BV; Mironova OV. 1979. Interaction of the mutant genes splotch and fidget in mice. Sov Genet 15:407-411.  [MGI Ref ID J:11996]

Konyukhov BV; Sazhina MV. 1976. The cell cycle and retinal histogenesis fidget mutant mice. Dev Biol 54(1):13-22. [PubMed: 1001817]  [MGI Ref ID J:5736]

Konyukhov BV; Wachtel AW. 1963. Electrophoretic studies of proteins in normal lenses and cataracts of inbred and mutant mice Exp Eye Res 2:325-30. [PubMed: 14073604]  [MGI Ref ID J:268]

Nadeau JH. 2001. Modifier genes in mice and humans. Nat Rev Genet 2(3):165-74. [PubMed: 11256068]  [MGI Ref ID J:88013]

Stubbs L; Huxley C; Hogan B; Evans T; Fried M; Duboule D; Lehrach H. 1990. The HOX-5 and surfeit gene clusters are linked in the proximal portion of mouse chromosome 2. Genomics 6(4):645-50. [PubMed: 1971250]  [MGI Ref ID J:10508]

Truslove GM. 1956. The anatomy and development of the fidget mouse. J Genet 54:64-86.  [MGI Ref ID J:13048]

Wallace ME. 1976. Hydronephrosis in the mouse: the effects of the short-ear gene, sex and ureteral vascular system. Am J Anat 147(1):1932. [PubMed: 970345]  [MGI Ref ID J:5695]

Yang Y; Mahaffey CL; Berube N; Frankel WN. 2006. Interaction between fidgetin and protein kinase A-anchoring protein AKAP95 is critical for palatogenesis in the mouse. J Biol Chem 281(31):22352-9. [PubMed: 16751186]  [MGI Ref ID J:116474]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2085.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2710.50
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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