Strain Name:

B6.CXB1-Pde6brd10/J

Stock Number:

004297

Order this mouse

Availability:

Research Strain

Retinal degeneration 10 (rd10) is a spontaneous missense point mutation in Pde6b (cGMP phosphodiesterase 6B, rod receptor, beta polypeptide). Although similar to rd1, the rd10 phenotype has a later onset and milder retinal degeneration and may provide a better experimental drug therapy model for retinitis pigmentosa.

Description

Strain Information

Type Congenic; Mutant Strain; Spontaneous Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Mating SystemHomozygote x Homozygote         (Female x Male)   18-MAY-09
Specieslaboratory mouse
Background Strain C57BL/6J
Donor Strain CXB-1/By
GenerationN5F15 (20-DEC-04)
Generation Definitions

Appearance
black
Related Genotype: a/a

Description
Pde6b (cGMP phosphodiesterase 6B, rod receptor, beta polypeptide) encodes the beta subunit of phosphodiesterase (PDE), a peripheral membrane enzyme involved in the phototransduction cascade in rod photoreceptors. Mutations in PDE are associated with retinitis pigmentosa and night blindness. Mice homozygous for retinal degeneration 10 (rd10) exhibit sclerotic retinal vessels at 4 weeks of age, progressive retinal outer nuclear layer degeneration beginning at 16 days, and a progressive decline in rod and cone ERG a- and b- waves. Retinal degeneration is delayed by approximately a week in mice raised in total darkness. Although similar to rd1, the rd10 phenotype has a later onset and milder retinal degeneration and may provide a better experimental drug therapy model for retinitis pigmentosa.

Development
The retinal degeneration 10 mutation was identified as a segregating mutation in the CXB1/TyJ strain at The Jackson Laboratory in approximately 1998. Through selective breeding the rd10 mutation was bred out of the CXB1/TyJ recombinant inbred strain, while at the same time the rd10 mutation was backcrossed onto the C57BL/6J background for 5 generations before intercrossing to homozygosity. Sequence analysis demonstrated that the rd10 allele is a missense point mutation in exon 13.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Pde6b
004202   B6.C3 Pde6brd1 Hps4le/+ +-Lmx1adr-8J/J
000002   B6.C3-Pde6brd1 Hps4le/J
001022   B6C3FeF1/J a/a
005252   B6EiC3Sn.BLiA-Ts(1716)65Dn/DnJ
003647   B6EiC3Sn.BLiAF1/J
000652   BDP/J
000653   BUB/BnJ
002439   C3.129P2(B6)-B2mtm1Unc/J
005494   C3.129S1(B6)-Grm1rcw/J
002802   C3.BLiA Pde6b+-Krd/J
000509   C3.Cg-Lystbg-2J/J
000480   C3.MRL-Faslpr/J
001957   C3A Pde6brd1.O20/A-Prph2Rd2/J
001912   C3A.BLiA-Pde6b+/J
024700   C3A.Cg-Pde6b+ Bmp4tm1Blh/SjJ
001979   C3A.Cg-Pde6b+ Prph2Rd2/J
024703   C3A.Cg-Pde6b+Tg(Thy1-CFP)23Jrs/SjJ
004326   C3Bir.129P2(B6)-Il10tm1Cgn/Lt
003968   C3Bir.129P2(B6)-Il10tm1Cgn/LtJ
006435   C3Fe.SW-Soaa/MonJ
001904   C3H-Atcayji-hes/J
000659   C3H/HeJ
000511   C3H/HeJ-Ap3d1mh-2J/J
000784   C3H/HeJ-Faslgld/J
002433   C3H/HeJ-Sptbn4qv-lnd2J/J
005972   C3H/HeJBirLtJ
001824   C3H/HeJSxJ
000635   C3H/HeOuJ
000474   C3H/HeSn
001431   C3H/HeSn-ocd/J
000661   C3H/HeSnJ
002333   C3H/HeSnJ-gri/J
001576   C3He-Atp7btx-J/J
000658   C3HeB/FeJ
002588   C3HeB/FeJ-Eya1bor/J
001533   C3HeB/FeJ-Mc1rE-so Gli3Xt-J/J
001908   C3HfB/BiJ
001502   C3Sn.B6-Epha4rb/EiGrsrJ
003648   C3Sn.BLiA-Pde6b+/DnJ
002235   C3Sn.C3-Ctnna2cdf/J
001547   C3Sn.Cg-Cm/J
001906   C3fBAnl.Cg-Catb/AnlJ
004766   C57BL/6J-Pde6brd1-2J/J
000656   CBA/J
000813   CBA/J-Atp7aMo-pew/J
000660   DA/HuSnJ
000023   FL/1ReJ
000025   FL/4ReJ
003024   FVB.129P2(B6)-Fmr1tm1Cgr/J
002539   FVB.129P2-Abcb4tm1Bor/J
004624   FVB.129P2-Pde6b+ Tyrc-ch Fmr1tm1Cgr/J
004828   FVB.129P2-Pde6b+ Tyrc-ch/AntJ
002935   FVB.129S2(B6)-Ccnd1tm1Wbg/J
002953   FVB.Cg-Tg(MMTVTGFA)254Rjc/J
003170   FVB.Cg-Tg(Myh6-tTA)6Smbf/J
003078   FVB.Cg-Tg(WapIgf1)39Dlr/J
003487   FVB.Cg-Tg(XGFAP-lacZ)3Mes/J
003257   FVB/N-Tg(GFAPGFP)14Mes/J
002856   FVB/N-Tg(TIE2-lacZ)182Sato/J
002384   FVB/N-Tg(UcpDta)1Kz/J
001800   FVB/NJ
001491   FVB/NMob
000804   HPG/BmJ
000734   MOLD/RkJ
000550   MOLF/EiJ
002423   NON/ShiLtJ
000679   P/J
000680   PL/J
000268   RSV/LeJ
000269   SB/LeJ
010968   SB;C3Sn-Lrp4mdig-2J/GrsrJ
005651   SJL.AK-Thy1a/TseJ
000686   SJL/J
000688   ST/bJ
004808   STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
002648   STOCK a/a Cln6nclf/J
000279   STOCK gr +/+ Ap3d1mh/J
005965   STOCK Tg(Pomc1-cre)16Lowl/J
004770   SW.B6-Soab/J
002023   SWR.M-Emv21 Emv22/J
000689   SWR/J
000939   SWR/J-Clcn1adr-mto/J
000692   WB/ReJ KitW/J
100410   WBB6F1/J-KitW/KitW-v/J
000693   WC/ReJ KitlSl/J
View Strains carrying other alleles of Pde6b     (85 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Model with phenotypic similarity to human disease where etiologies are distinct. Human genes are associated with this disease. Orthologs of these genes do not appear in the mouse genotype(s).
Retinitis Pigmentosa; RP
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Night Blindness, Congenital Stationary, Autosomal Dominant 2; CSNBAD2   (PDE6B)
Retinitis Pigmentosa 40; RP40   (PDE6B)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Pde6brd10/Pde6brd10

        B6.CXB1-Pde6brd10/J
  • vision/eye phenotype
  • *normal* vision/eye phenotype   (MGI Ref ID J:122722)
    • abnormal eye electrophysiology
      • mice showed reduced rod and cone responses under both dark- and light-adapted conditions compared to wild-type   (MGI Ref ID J:122722)
      • a small a-wave appeared only at the brightest flash intensity indicating loss of sensitivity in dark-adapted, 30 day old mice   (MGI Ref ID J:122722)
      • the loss of cone function was not registered as fast by b-wave response from light-adapted compared to dark-adapted mice   (MGI Ref ID J:122722)
      • ERG a- and b- wave amplitudes are greater in mice treated with tauroursodeoxycholic acid   (MGI Ref ID J:117305)
    • abnormal retinal rod cell morphology   (MGI Ref ID J:122722)
      • retinal rod cell degeneration
        • rod photoreceptor cells start degenerating in the central retina at 16 days of age and in the peripheral retina at 20 days of age   (MGI Ref ID J:122722)
        • by 60 days of age no photoreceptors remain   (MGI Ref ID J:122722)
    • abnormal retinal vasculature morphology
      • sclerotic retinal vessels are observed at 4 weeks of age   (MGI Ref ID J:122722)
    • retinal degeneration
      • clinical abnormalities are observable at 4 weeks of age   (MGI Ref ID J:122722)
      • histological analyses show progressive retinal outer nuclear layer degeneration (ONL) beginning in the center at 16 days of age and spreading to the periphery by 20 days of age   (MGI Ref ID J:122722)
      • by 60 days of age no ONL remains   (MGI Ref ID J:122722)
      • nuclei counts in the ONL over time reflects progressive degeneration; inner nuclear layers are not affected   (MGI Ref ID J:122722)
      • dark-reared mice showed no degeneration until 24 days of age with initial nuclei loss apparent at 30 days   (MGI Ref ID J:122722)
      • tauroursodeoxycholic acid slows onset of degeneration of retinal outer nuclear layers and photoreceptors   (MGI Ref ID J:117305)
    • retinal outer nuclear layer degeneration
      • histological analyses show progressive retinal outer nuclear layer degeneration (ONL) beginning in the center at 16 days of age and spreading to the periphery by 20 days of age   (MGI Ref ID J:122722)
  • cardiovascular system phenotype
  • abnormal retinal vasculature morphology
    • sclerotic retinal vessels are observed at 4 weeks of age   (MGI Ref ID J:122722)
  • nervous system phenotype
  • abnormal retinal rod cell morphology   (MGI Ref ID J:122722)
    • retinal rod cell degeneration
      • rod photoreceptor cells start degenerating in the central retina at 16 days of age and in the peripheral retina at 20 days of age   (MGI Ref ID J:122722)
      • by 60 days of age no photoreceptors remain   (MGI Ref ID J:122722)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Pde6brd10 related

Sensorineural Research
Retinal Degeneration

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Pde6brd10
Allele Name retinal degeneration 10
Allele Type Spontaneous
Common Name(s) Pde6brd1-J; rd10;
Strain of OriginCXB1/ByJ
Gene Symbol and Name Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
Chromosome 5
Gene Common Name(s) CSNB3; CSNBAD2; PDEB; Pdeb; RP40; nmf137; phosphodiesterase, cGMP, rod receptor, beta polypeptide; r; rd; rd-1; rd1; rd10; retinal degeneration; retinal degeneration 1; retinal degeneration 10;
Molecular Note An initial complementation test with Pde6b rd1 demonstrated allelism. Sequence analysis shows that the rd10 mutation is caused by a missense mutation in exon 13, which encodes the beta subunit of the protein. [MGI Ref ID J:75095]

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Pde6brd10 related

Allocca M; Manfredi A; Iodice C; Di Vicino U; Auricchio A. 2011. AAV-mediated gene replacement, either alone or in combination with physical and pharmacological agents, results in partial and transient protection from photoreceptor degeneration associated with betaPDE deficiency. Invest Ophthalmol Vis Sci 52(8):5713-9. [PubMed: 21273543]  [MGI Ref ID J:181448]

Arroba AI; Alvarez-Lindo N; van Rooijen N; de la Rosa EJ. 2011. Microglia-mediated IGF-I neuroprotection in the rd10 mouse model of retinitis pigmentosa. Invest Ophthalmol Vis Sci 52(12):9124-30. [PubMed: 22039242]  [MGI Ref ID J:191398]

Barhoum R; Martinez-Navarrete G; Corrochano S; Germain F; Fernandez-Sanchez L; de la Rosa EJ; de la Villa P; Cuenca N. 2008. Functional and structural modifications during retinal degeneration in the rd10 mouse. Neuroscience 155(3):698-713. [PubMed: 18639614]  [MGI Ref ID J:140868]

Barone I; Novelli E; Piano I; Gargini C; Strettoi E. 2012. Environmental enrichment extends photoreceptor survival and visual function in a mouse model of retinitis pigmentosa. PLoS One 7(11):e50726. [PubMed: 23209820]  [MGI Ref ID J:195565]

Boatright JH; Moring AG; McElroy C; Phillips MJ; Do VT; Chang B; Hawes NL; Boyd AP; Sidney SS; Stewart RE; Minear SC; Chaudhury R; Ciavatta VT; Rodrigues CM; Steer CJ; Nickerson JM; Pardue MT. 2006. Tool from ancient pharmacopoeia prevents vision loss. Mol Vis 12:1706-14. [PubMed: 17213800]  [MGI Ref ID J:117305]

Chang B; Hawes NL; Hurd RE; Davisson MT; Nusinowitz S; Heckenlively JR. 2002. Retinal degeneration mutants in the mouse. Vision Res 42(4):517-25. [PubMed: 11853768]  [MGI Ref ID J:75095]

Chang B; Hawes NL; Hurd RE; Wang J; Howell D; Davisson MT; Roderick TH; Nusinowitz S; Heckenlively JR. 2005. Mouse models of ocular diseases. Vis Neurosci 22(5):587-93. [PubMed: 16332269]  [MGI Ref ID J:156373]

Chang B; Hawes NL; Pardue MT; German AM; Hurd RE; Davisson MT; Nusinowitz S; Rengarajan K; Boyd AP; Sidney SS; Phillips MJ; Stewart RE; Chaudhury R; Nickerson JM; Heckenlively JR; Boatright JH. 2007. Two mouse retinal degenerations caused by missense mutations in the beta-subunit of rod cGMP phosphodiesterase gene. Vision Res 47(5):624-33. [PubMed: 17267005]  [MGI Ref ID J:122722]

Corrochano S; Barhoum R; Boya P; Arroba AI; Rodriguez-Muela N; Gomez-Vicente V; Bosch F; de Pablo F; de la Villa P; de la Rosa EJ. 2008. Attenuation of vision loss and delay in apoptosis of photoreceptors induced by proinsulin in a mouse model of retinitis pigmentosa. Invest Ophthalmol Vis Sci 49(9):4188-94. [PubMed: 18515565]  [MGI Ref ID J:141803]

Deleon E; Lederman M; Berenstein E; Meir T; Chevion M; Chowers I. 2009. Alteration in iron metabolism during retinal degeneration in rd10 mouse. Invest Ophthalmol Vis Sci 50(3):1360-5. [PubMed: 18997094]  [MGI Ref ID J:146676]

Della Santina L; Bouly M; Asta A; Demontis GC; Cervetto L; Gargini C. 2010. Effect of HCN channel inhibition on retinal morphology and function in normal and dystrophic rodents. Invest Ophthalmol Vis Sci 51(2):1016-23. [PubMed: 19741244]  [MGI Ref ID J:160427]

Deng WT; Sakurai K; Kolandaivelu S; Kolesnikov AV; Dinculescu A; Li J; Zhu P; Liu X; Pang J; Chiodo VA; Boye SL; Chang B; Ramamurthy V; Kefalov VJ; Hauswirth WW. 2013. Cone Phosphodiesterase-6alpha' Restores Rod Function and Confers Distinct Physiological Properties in the Rod Phosphodiesterase-6beta-Deficient rd10 Mouse. J Neurosci 33(29):11745-53. [PubMed: 23864662]  [MGI Ref ID J:199811]

Egger A; Samardzija M; Sothilingam V; Tanimoto N; Lange C; Salatino S; Fang L; Garcia-Garrido M; Beck S; Okoniewski MJ; Neutzner A; Seeliger MW; Grimm C; Handschin C. 2012. PGC-1alpha determines light damage susceptibility of the murine retina. PLoS One 7(2):e31272. [PubMed: 22348062]  [MGI Ref ID J:185229]

Gargini C; Terzibasi E; Mazzoni F; Strettoi E. 2007. Retinal organization in the retinal degeneration 10 (rd10) mutant mouse: a morphological and ERG study. J Comp Neurol 500(2):222-38. [PubMed: 17111372]  [MGI Ref ID J:132845]

Grossman GH; Pauer GJ; Narendra U; Peachey NS; Hagstrom SA. 2009. Early synaptic defects in tulp1-/- mice. Invest Ophthalmol Vis Sci 50(7):3074-83. [PubMed: 19218615]  [MGI Ref ID J:154571]

Guo C; Otani A; Oishi A; Kojima H; Makiyama Y; Nakagawa S; Yoshimura N. 2012. Knockout of ccr2 alleviates photoreceptor cell death in a model of retinitis pigmentosa. Exp Eye Res 104:39-47. [PubMed: 23022404]  [MGI Ref ID J:203669]

Heynen SR; Tanimoto N; Joly S; Seeliger MW; Samardzija M; Grimm C. 2011. Retinal degeneration modulates intracellular localization of CDC42 in photoreceptors. Mol Vis 17:2934-46. [PubMed: 22128240]  [MGI Ref ID J:179662]

Jaliffa C; Ameqrane I; Dansault A; Leemput J; Vieira V; Lacassagne E; Provost A; Bigot K; Masson C; Menasche M; Abitbol M. 2009. Sirt1 involvement in rd10 mouse retinal degeneration. Invest Ophthalmol Vis Sci 50(8):3562-72. [PubMed: 19407027]  [MGI Ref ID J:154506]

Mazzoni F; Novelli E; Strettoi E. 2008. Retinal ganglion cells survive and maintain normal dendritic morphology in a mouse model of inherited photoreceptor degeneration. J Neurosci 28(52):14282-92. [PubMed: 19109509]  [MGI Ref ID J:143877]

Murakami Y; Ikeda Y; Yoshida N; Notomi S; Hisatomi T; Oka S; De Luca G; Yonemitsu Y; Bignami M; Nakabeppu Y; Ishibashi T. 2012. MutT Homolog-1 Attenuates Oxidative DNA Damage and Delays Photoreceptor Cell Death in Inherited Retinal Degeneration. Am J Pathol 181(4):1378-86. [PubMed: 22841817]  [MGI Ref ID J:188705]

Murakami Y; Matsumoto H; Roh M; Suzuki J; Hisatomi T; Ikeda Y; Miller JW; Vavvas DG. 2012. Receptor interacting protein kinase mediates necrotic cone but not rod cell death in a mouse model of inherited degeneration. Proc Natl Acad Sci U S A 109(36):14598-603. [PubMed: 22908283]  [MGI Ref ID J:189891]

Ohnaka M; Miki K; Gong YY; Stevens R; Iwase T; Hackett SF; Campochiaro PA. 2012. Long-term expression of glial cell line-derived neurotrophic factor slows, but does not stop retinal degeneration in a model of retinitis pigmentosa. J Neurochem 122(5):1047-53. [PubMed: 22726126]  [MGI Ref ID J:187648]

Otani A; Kojima H; Guo C; Oishi A; Yoshimura N. 2012. Low-dose-rate, low-dose irradiation delays neurodegeneration in a model of retinitis pigmentosa. Am J Pathol 180(1):328-36. [PubMed: 22074737]  [MGI Ref ID J:180155]

Pang JJ; Boye SL; Kumar A; Dinculescu A; Deng W; Li J; Li Q; Rani A; Foster TC; Chang B; Hawes NL; Boatright JH; Hauswirth WW. 2008. AAV-mediated gene therapy for retinal degeneration in the rd10 mouse containing a recessive PDEbeta mutation. Invest Ophthalmol Vis Sci 49(10):4278-83. [PubMed: 18586879]  [MGI Ref ID J:140150]

Park H; Tan CC; Faulkner A; Jabbar SB; Schmid G; Abey J; Iuvone PM; Pardue MT. 2013. Retinal degeneration increases susceptibility to myopia in mice. Mol Vis 19:2068-79. [PubMed: 24146540]  [MGI Ref ID J:205341]

Phillips MJ; Walker TA; Choi HY; Faulkner AE; Kim MK; Sidney SS; Boyd AP; Nickerson JM; Boatright JH; Pardue MT. 2008. Tauroursodeoxycholic acid preservation of photoreceptor structure and function in the rd10 mouse through postnatal day 30. Invest Ophthalmol Vis Sci 49(5):2148-55. [PubMed: 18436848]  [MGI Ref ID J:135201]

Picard E; Jonet L; Sergeant C; Vesvres MH; Behar-Cohen F; Courtois Y; Jeanny JC. 2010. Overexpressed or intraperitoneally injected human transferrin prevents photoreceptor degeneration in rd10 mice. Mol Vis 16:2612-25. [PubMed: 21179240]  [MGI Ref ID J:168999]

Puthussery T; Gayet-Primo J; Pandey S; Duvoisin RM; Taylor WR. 2009. Differential loss and preservation of glutamate receptor function in bipolar cells in the rd10 mouse model of retinitis pigmentosa. Eur J Neurosci 29(8):1533-42. [PubMed: 19385989]  [MGI Ref ID J:148499]

Samardzija M; Wariwoda H; Imsand C; Huber P; Heynen SR; Gubler A; Grimm C. 2012. Activation of survival pathways in the degenerating retina of rd10 mice. Exp Eye Res 99:17-26. [PubMed: 22546314]  [MGI Ref ID J:196816]

Sasahara M; Otani A; Oishi A; Kojima H; Yodoi Y; Kameda T; Nakamura H; Yoshimura N. 2008. Activation of bone marrow-derived microglia promotes photoreceptor survival in inherited retinal degeneration. Am J Pathol 172(6):1693-703. [PubMed: 18483210]  [MGI Ref ID J:136339]

Singh B; Wilson JH; Vasavada HH; Guo Z; Allore HG; Zeiss CJ. 2007. Motor deficits and altered striatal gene expression in aphakia (ak) mice. Brain Res 1185:283-92. [PubMed: 17949697]  [MGI Ref ID J:128707]

Strettoi E; Gargini C; Novelli E; Sala G; Piano I; Gasco P; Ghidoni R. 2010. Inhibition of ceramide biosynthesis preserves photoreceptor structure and function in a mouse model of retinitis pigmentosa. Proc Natl Acad Sci U S A 107(43):18706-11. [PubMed: 20937879]  [MGI Ref ID J:165509]

Usui S; Oveson BC; Iwase T; Lu L; Lee SY; Jo YJ; Wu Z; Choi EY; Samulski RJ; Campochiaro PA. 2011. Overexpression of SOD in retina: Need for increase in H(2)O(2)-detoxifying enzyme in same cellular compartment. Free Radic Biol Med 51(7):1347-54. [PubMed: 21736939]  [MGI Ref ID J:175696]

Won J; Shi LY; Hicks W; Wang J; Hurd R; Naggert JK; Chang B; Nishina PM. 2011. Mouse model resources for vision research. J Ophthalmol 2011:391384. [PubMed: 21052544]  [MGI Ref ID J:166679]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           A1

Colony Maintenance

Mating SystemHomozygote x Homozygote         (Female x Male)   18-MAY-09

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $141.00Female or MaleHomozygous for Pde6brd10  
Price per Pair (US dollars $)Pair Genotype
$281.95Homozygous for Pde6brd10 x Homozygous for Pde6brd10  

Standard Supply

Research Strain. Availability determined by The Jackson Laboratory scientist holding the strain.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $183.30Female or MaleHomozygous for Pde6brd10  
Price per Pair (US dollars $)Pair Genotype
$366.60Homozygous for Pde6brd10 x Homozygous for Pde6brd10  

Standard Supply

Research Strain. Availability determined by The Jackson Laboratory scientist holding the strain.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Research Strain. Availability determined by The Jackson Laboratory scientist holding the strain.

General Supply Notes

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


(6.8)