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Strain Name:

B6.CXB1-Pde6brd10/J

Stock Number:

004297

Availability:

Repository- Live

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General Terms and Conditions

Genes & Alleles   Pde6b;   Pde6brd10;

Product Information

Strain Details

Type JAX® GEMM® Strain - Congenic
Additional information on JAX® GEMM® Strains.
Type JAX® GEMM® Strain - Mutant Strain
Type JAX® GEMM® Strain - Spontaneous Mutation
Specieslaboratory mouse
Background Strain C57BL/6J
Donor Strain CXB-1/By
GenerationN5F15 (20-DEC-04)

Appearance
black
Related Genotype: a/a

Mammalian Phenotype Terms assigned by genotype

Pde6brd10/Pde6brd10

        B6.CXB1-Pde6brd10/J
  • vision/eye phenotype
  • *normal* vision/eye phenotype (J:122722)
    • abnormal eye electrophysiology (J:122722)
      • mice showed reduced rod and cone responses under both dark- and light-adapted conditions compared to wild-type
      • a small a-wave appeared only at the brightest flash intensity indicating loss of sensitivity in dark-adapted, 30 day old mice
      • the loss of cone function was not registered as fast by b-wave response from light-adapted compared to dark-adapted mice
      • ERG a- and b- wave amplitudes are greater in mice treated with tauroursodeoxycholic acid
    • abnormal retinal rod cell morphology (J:122722)
      • retinal rod cell degeneration (J:122722)
        • rod photoreceptor cells start degenerating in the central retina at 16 days of age and in the peripheral retina at 20 days of age
        • by 60 days of age no photoreceptors remain
    • abnormal retinal vasculature (J:122722)
      • sclerotic retinal vessels are observed at 4 weeks of age
    • retinal degeneration (J:122722)
      • clinical abnormalities are observable at 4 weeks of age
      • histological analyses show progressive retinal outer nuclear layer degeneration (ONL) beginning in the center at 16 days of age and spreading to the periphery by 20 days of age
      • by 60 days of age no ONL remains
      • nuclei counts in the ONL over time reflects progressive degeneration; inner nuclear layers are not affected
      • dark-reared mice showed no degeneration until 24 days of age with initial nuclei loss apparent at 30 days
      • tauroursodeoxycholic acid slows onset of degeneration of retinal outer nuclear layers and photoreceptors
    • retinal outer nuclear layer degeneration (J:122722)
      • histological analyses show progressive retinal outer nuclear layer degeneration (ONL) beginning in the center at 16 days of age and spreading to the periphery by 20 days of age
  • cardiovascular system phenotype
  • abnormal retinal vasculature (J:122722)
    • sclerotic retinal vessels are observed at 4 weeks of age
  • nervous system phenotype
  • abnormal retinal rod cell morphology (J:122722)
    • retinal rod cell degeneration (J:122722)
      • rod photoreceptor cells start degenerating in the central retina at 16 days of age and in the peripheral retina at 20 days of age
      • by 60 days of age no photoreceptors remain

Gene & Allele Details

Allele Symbol Pde6brd10
Allele Name retinal degeneration 10
Common Name(s) Pde6brd1-J; rd10;
Strain of OriginCXB1/ByJ
Gene Symbol and Name Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
Chromosome 5
Gene Common Name(s) CSNB3; PDEB; Pdeb; RP40; nmf137; phosphodiesterase, cGMP, rod receptor, beta polypeptide; r; rd; rd-1; rd1; rd10; retinal degeneration; retinal degeneration 1; retinal degeneration 10;
Molecular Note An initial complementation test with Pde6b rd1 demonstrated allelism. Sequence analysis shows that the rd10 mutation is caused by a missense mutation in exon 13, which encodes the beta subunit of the protein. [J:75095]

Control Information

  Allele   Control
 Pde6brd10  000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Pde6b
004202   B6.C3 Pde6brd1 Hps4le/+ +-Lmx1adr-8J/J
000002   B6.C3-Pde6brd1 Hps4le/J
001022   B6C3FeF1/J a/a
000652   BDP/J
000653   BUB/BnJ
002439   C3.129P2(B6)-B2mtm1Unc/J
005494   C3.129S1(B6)-Grm1rcw/J
002802   C3.BLiA Pde6b+-Krd/J
000480   C3.MRL-Faslpr/J
001957   C3A Pde6brd1.O20/A-Prph2Rd2/J
001979   C3A.BLiA-Pde6b+.O20-Prph2Rd2/J
001912   C3A.BLiA-Pde6b+/J
005973   C3Bir.129P2(B6)-Il10C3Bir/LtJ
004326   C3Bir.129P2(B6)-Il10tm1Cgn/Lt
003968   C3Bir.129P2(B6)-Il10tm1Cgn/LtJ
001906   C3Ga.Cg-Catb/J
001904   C3H-Atcayji-hes/J
000659   C3H/HeJ
000784   C3H/HeJ-Faslgld/J
000509   C3H/HeJ-Lystbg-2J/J
002433   C3H/HeJ-Spnb4qv-lnd2J/J
005972   C3H/HeJBirLtJ
001824   C3H/HeJSxJ
000635   C3H/HeOuJ
000474   C3H/HeSn
001431   C3H/HeSn-ocd/J
000661   C3H/HeSnJ
002235   C3H/HeSnJ-Ctnna2cdf/J
002333   C3H/HeSnJ-gri/J
006435   C3HeB.SW-Soaa/MonJ
000658   C3HeB/FeJ
001576   C3HeB/FeJ-Atp7btx-J/J
002588   C3HeB/FeJ-Eya1bor/J
001533   C3HeB/FeJ-Mc1rE-so Gli3Xt-J/J
001886   C3HeB/FeJLe a/a-gnd/J
001908   C3HfB/BiJ
001502   C3Sn.B6-Epha4rb/J
003648   C3Sn.BLiA-Pde6b+/Dn
001547   C3Sn.Cg-Cm/J
004766   C57BL/6J-Pde6brd1-2J/J
000656   CBA/J
000813   CBA/J-Atp7aMo-pew/J
000660   DA/HuSnJ
000023   FL/1ReJ
000025   FL/4ReJ
003078   FVB-Tg(WapIgf1)39Dlr/J
003024   FVB.129P2(B6)-Fmr1tm1Cgr/J
002539   FVB.129P2-Abcb4tm1Bor/J
004828   FVB.129P2-Pde6b+ Tyrc-ch/AntJ
002935   FVB.129S2(B6)-Ccnd1tm1Wbg/J
002953   FVB.Cg-Tg(MMTVTGFA)254Rjc/J
003170   FVB.Cg-Tg(Myh6-tTA)6Smbf/J
003257   FVB/N-Tg(GFAPGFP)14Mes/J
002374   FVB/N-Tg(MMTV-PyVT)634Mul/J
002856   FVB/N-Tg(TIE2-lacZ)182Sato/J
002384   FVB/N-Tg(UcpDta)1Kz/J
001800   FVB/NJ
003487   FVB/NJ-Tg(XGFAP-lacZ)3Mes/J
001491   FVB/NMob
000734   MOLD/RkJ
000550   MOLF/EiJ
002423   NON/ShiLtJ
000679   P/J
000680   PL/J
100299   PLSJLF1/J
000269   SB/LeJ
005651   SJL.AK-Thy1a/TseJ
000686   SJL/J
000688   ST/bJ
004808   STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
002648   STOCK a/a Cln6nclf/J
000279   STOCK gr +/+ Ap3d1mh/J
005965   STOCK Tg(Pomc1-cre)16Lowl/J
004770   SW.B6-Soab/J
002023   SWR.M-Emv21 Emv22/J
000689   SWR/J
000939   SWR/J-Clcn1adr-mto/J
000692   WB/ReJ KitW/J
100410   WBB6F1/J-KitW/KitW-v/J
000693   WC/ReJ KitlSl/J
100401   WCB6F1/J KitlSl KitlSl-d
View Strains carrying other alleles of Pde6b     (81 strains)

Additional Web Information

Congenic Nomenclature

Animal Health Reports

Room Number           A1

References

Additional References

Price and Supply Information

Strain Name: B6.CXB1-Pde6brd10/J
Stock Number: 004297

Price Details

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Supply Details

Standard SupplyRepository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.
Supply Notes Usually shipped between four and eight weeks of age.
This strain is included in the Eye Mutant Resource within the Mouse Mutant Resource collection.
LicensingSee General Terms and Conditions below  
Control InformationView Control Information in Strain Details.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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