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- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
- Health & care
- References
- Pricing & purchasing
- Terms of use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Former Names 129S1-Hprttm1(cre)Mnn/J (Changed: 28-DEC-09 ) 129S1-Hprt1tm1(cre)Mnn/J (Changed: 14-DEC-09 ) 129S1-Hprttm1(Cre)Mnn (Changed: 15-DEC-04 ) 129S1-Hprttm1(cre)Mnn/J (Changed: 15-DEC-04 ) Type Mutant Strain; Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Donating Investigator Jeff Mann, Murdoch Childrens Research Institute Description
Mice that are homozygous for the targeted mutation are viable and fertile. This is a Cre-deleter induced mutation strain on a 129S1 background. A Cre expression cassette was inserted into the X-linked Hprt gene. When male mice carrying a neomycin selection cassette flanked by loxP sites are mated to female mice heterozygous for this targeted mutation, the cassette is excised without detectable mosaicism, irrespective of cre inheritance. Heterozygous female mice have sufficient Cre recombinase in their oocytes to excise floxed sequence at the zygote or early cleavage stage.Development
A targeting vector containing a neomycin resistance gene driven by the mouse phosphoglycerate kinase 1 promoter and a Cre expression cassette containing cre driven by the cytomegalovirus early enhancer/chicken beta-globin promoter (CAG) was used to disrupt exon 3 of the targeted gene. The construct was electroporated into 129S1 derived W9.5 embryonic stem (ES) cells. Correctly targeted ES cells were injected into B6MB6F1 blastocysts. The resulting male chimeric animals were backcrossed to 129S1 mice.
Control Information
| Control | ||
|---|---|---|
| Wild-type female from the colony | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of Hprt
View Strains carrying other alleles of Hprt (53 strains)
Additional Web Information
Introduction to Cre-lox technology
Phenotype
Phenotype Information
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested. Kelley-Seegmiller Syndrome (HPRT1)
Lesch-Nyhan Syndrome; LNS (HPRT1)
This mouse can be used to support research in many areas including:
cre relatedResearch Tools
Cre-lox System
Cre Recombinase Expression
Cre Recombinase Expression: Germline/Embryonic Expression
Hprttm1(cre)Mnn relatedResearch Tools
Cre-lox System
Neurobiology Research
Neurodegeneration
Research Tools
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Hprttm1(cre)Mnn | ||
|---|---|---|---|
| Allele Name | targeted mutation 1, Jeffrey R Mann | ||
| Allele Type | Targeted (knock-in) | ||
| Common Name(s) | Hprt1tm1(cre)Mnn; Hprtcre; Hprttm1(CAG.cre)MdCoh; hprt-cre; | ||
| Mutation Made By | Jeff Mann, Murdoch Childrens Research Institute | ||
| Strain of Origin | 129S1/Sv-Oca2<+> Tyr<+> Kitl<+> | ||
| ES Cell Line Name | W9.5/W95 | ||
| ES Cell Line Strain | 129S1/Sv-Oca2<+> Tyr<+> Kitl<+> | ||
| Site of Expression | widespread pattern of expression; transgenic and wildtype oocytes both confer Cre activity | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Driver Note | CAG | ||
| Molecular Note | An expression cassette in which a CMV enhancer and chicken beta-globin promoter driving Cre recombinase expression was inserted in reverse transcriptional orientation into exon 3 of the gene. A PGK-neomycin selection cassette was also inserted followingthe cre gene. Expression of Cre recombinase occurred at high levels in the female germline and fertilized eggs, and all offspring of heterozyous females display excision of reporter sequences. [MGI Ref ID J:75826] | ||
| Gene Symbol and Name | Hprt, hypoxanthine guanine phosphoribosyl transferase | ||
| Chromosome | X | ||
| Gene Common Name(s) | C81579; HGPRT; Hgprtase; Hprt1; expressed sequence C81579; hypoxanthine guanine phosphoribosyl transferase 1; | ||
Genotyping
Genotyping Information
Genotyping Protocols
Hprttm1(Cre)Mnn, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Tang SH; Silva FJ; Tsark WM; Mann JR. 2002. A cre/loxP-deleter transgenic line in mouse strain 129S1/SvImJ. Genesis 32(3):199-202. [PubMed: 11892008] [MGI Ref ID J:75826]
Additional References
Hprttm1(cre)Mnn relatedAngus-Hill ML; Elbert KM; Hidalgo J; Capecchi MR. 2011. T-cell factor 4 functions as a tumor suppressor whose disruption modulates colon cell proliferation and tumorigenesis. Proc Natl Acad Sci U S A 108(12):4914-9. [PubMed: 21383188] [MGI Ref ID J:170088]
Birkenfeld AL; Lee HY; Guebre-Egziabher F; Alves TC; Jurczak MJ; Jornayvaz FR; Zhang D; Hsiao JJ; Martin-Montalvo A; Fischer-Rosinsky A; Spranger J; Pfeiffer AF; Jordan J; Fromm MF; Konig J; Lieske S; Carmean CM; Frederick DW; Weismann D; Knauf F; IrustaPM; De Cabo R; Helfand SL; Samuel VT; Shulman GI. 2011. Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice. Cell Metab 14(2):184-95. [PubMed: 21803289] [MGI Ref ID J:176732]
Caffery PM; Krishnaswamy A; Sanders T; Liu J; Hartlaub H; Klysik J; Cooper E; Hawrot E. 2009. Engineering neuronal nicotinic acetylcholine receptors with functional sensitivity to alpha-bungarotoxin: a novel alpha3-knock-in mouse. Eur J Neurosci 30(11):2064-76. [PubMed: 20128845] [MGI Ref ID J:157611]
Chan AC; Drakos SG; Ruiz OE; Smith AC; Gibson CC; Ling J; Passi SF; Stratman AN; Sacharidou A; Revelo MP; Grossmann AH; Diakos NA; Davis GE; Metzstein MM; Whitehead KJ; Li DY. 2011. Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice. J Clin Invest 121(5):1871-81. [PubMed: 21490399] [MGI Ref ID J:173947]
Chen IP; Wang CJ; Strecker S; Koczon-Jaremko B; Boskey A; Reichenberger EJ. 2009. Introduction of a Phe377del mutation in ANK creates a mouse model for craniometaphyseal dysplasia. J Bone Miner Res 24(7):1206-15. [PubMed: 19257826] [MGI Ref ID J:168526]
Fragoso R; Mao T; Wang S; Schaffert S; Gong X; Yue S; Luong R; Min H; Yashiro-Ohtani Y; Davis M; Pear W; Chen CZ. 2012. Modulating the strength and threshold of NOTCH oncogenic signals by mir-181a-1/b-1. PLoS Genet 8(8):e1002855. [PubMed: 22916024] [MGI Ref ID J:188125]
Gabel LA; Marin I; LoTurco JJ; Che A; Murphy C; Manglani M; Kass S. 2011. Mutation of the dyslexia-associated gene Dcdc2 impairs LTM and visuo-spatial performance in mice. Genes Brain Behav 10(8):868-75. [PubMed: 21883923] [MGI Ref ID J:188826]
Ghosh M; Aguila HL; Michaud J; Ai Y; Wu MT; Hemmes A; Ristimaki A; Guo C; Furneaux H; Hla T. 2009. Essential role of the RNA-binding protein HuR in progenitor cell survival in mice. J Clin Invest 119(12):3530-43. [PubMed: 19884656] [MGI Ref ID J:155109]
Gu L; Tsark WM; Brown DA; Blanchard S; Synold TW; Kane SE. 2009. A new model for studying tissue-specific mdr1a gene expression in vivo by live imaging. Proc Natl Acad Sci U S A 106(13):5394-9. [PubMed: 19282474] [MGI Ref ID J:147139]
Haldar M; Hancock JD; Coffin CM; Lessnick SL; Capecchi MR. 2007. A conditional mouse model of synovial sarcoma: insights into a myogenic origin. Cancer Cell 11(4):375-88. [PubMed: 17418413] [MGI Ref ID J:120967]
Haldar M; Karan G; Tvrdik P; Capecchi MR. 2008. Two cell lineages, myf5 and myf5-independent, participate in mouse skeletal myogenesis. Dev Cell 14(3):437-45. [PubMed: 18331721] [MGI Ref ID J:133338]
Hippenmeyer S; Johnson RL; Luo L. 2013. Mosaic Analysis with Double Markers Reveals Cell-Type-Specific Paternal Growth Dominance. Cell Rep :. [PubMed: 23453967] [MGI Ref ID J:194079]
Hopp K; Ward CJ; Hommerding CJ; Nasr SH; Tuan HF; Gainullin VG; Rossetti S; Torres VE; Harris PC. 2012. Functional polycystin-1 dosage governs autosomal dominant polycystic kidney disease severity. J Clin Invest 122(11):4257-73. [PubMed: 23064367] [MGI Ref ID J:193544]
Hu H; Li J; Gagen CS; Gray NW; Zhang Z; Qi Y; Zhang P. 2011. Conditional knockout of protein O-mannosyltransferase 2 reveals tissue-specific roles of O-mannosyl glycosylation in brain development. J Comp Neurol 519(7):1320-37. [PubMed: 21452199] [MGI Ref ID J:179356]
Jones KB; Piombo V; Searby C; Kurriger G; Yang B; Grabellus F; Roughley PJ; Morcuende JA; Buckwalter JA; Capecchi MR; Vortkamp A; Sheffield VC. 2010. A mouse model of osteochondromagenesis from clonal inactivation of Ext1 in chondrocytes. Proc Natl Acad Sci U S A 107(5):2054-9. [PubMed: 20080592] [MGI Ref ID J:157599]
Jors S; Grimm C; Becker L; Heller S. 2010. Genetic inactivation of Trpml3 does not lead to hearing and vestibular impairment in mice. PLoS One 5(12):e14317. [PubMed: 21179200] [MGI Ref ID J:167711]
Kaftanovskaya EM; Feng S; Huang Z; Tan Y; Barbara AM; Kaur S; Truong A; Gorlov IP; Agoulnik AI. 2011. Suppression of insulin-like3 receptor reveals the role of beta-catenin and Notch signaling in gubernaculum development. Mol Endocrinol 25(1):170-83. [PubMed: 21147849] [MGI Ref ID J:182895]
Kopinke D; Brailsford M; Pan FC; Magnuson MA; Wright CV; Murtaugh LC. 2012. Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas. Dev Biol 362(1):57-64. [PubMed: 22146645] [MGI Ref ID J:180310]
Kuhnert F; Mancuso MR; Hampton J; Stankunas K; Asano T; Chen CZ; Kuo CJ. 2008. Attribution of vascular phenotypes of the murine Egfl7 locus to the microRNA miR-126. Development 135(24):3989-93. [PubMed: 18987025] [MGI Ref ID J:143206]
Lehre AC; Rowley NM; Zhou Y; Holmseth S; Guo C; Holen T; Hua R; Laake P; Olofsson AM; Poblete-Naredo I; Rusakov DA; Madsen KK; Clausen RP; Schousboe A; White HS; Danbolt NC. 2011. Deletion of the betaine-GABA transporter (BGT1; slc6a12) gene does not affect seizure thresholds of adult mice. Epilepsy Res 95(1-2):70-81. [PubMed: 21459558] [MGI Ref ID J:180428]
Liu W; Shaver TM; Balasa A; Ljungberg MC; Wang X; Wen S; Nguyen H; Van den Veyver IB. 2012. Deletion of Porcn in mice leads to multiple developmental defects and models human focal dermal hypoplasia (Goltz syndrome). PLoS One 7(3):e32331. [PubMed: 22412863] [MGI Ref ID J:186934]
Ma XM; Kiraly DD; Gaier ED; Wang Y; Kim EJ; Levine ES; Eipper BA; Mains RE. 2008. Kalirin-7 is required for synaptic structure and function. J Neurosci 28(47):12368-82. [PubMed: 19020030] [MGI Ref ID J:142364]
Makki N; Capecchi MR. 2011. Identification of novel Hoxa1 downstream targets regulating hindbrain, neural crest and inner ear development. Dev Biol 357(2):295-304. [PubMed: 21784065] [MGI Ref ID J:175781]
Mathew SJ; Hansen JM; Merrell AJ; Murphy MM; Lawson JA; Hutcheson DA; Hansen MS; Angus-Hill M; Kardon G. 2011. Connective tissue fibroblasts and Tcf4 regulate myogenesis. Development 138(2):371-84. [PubMed: 21177349] [MGI Ref ID J:167712]
McMahon A; Butovich IA; Kedzierski W. 2011. Epidermal expression of an Elovl4 transgene rescues neonatal lethality of homozygous Stargardt disease-3 mice. J Lipid Res 52(6):1128-38. [PubMed: 21429867] [MGI Ref ID J:173583]
McMahon A; Butovich IA; Mata NL; Klein M; Ritter R rd; Richardson J; Birch DG; Edwards AO; Kedzierski W. 2007. Retinal pathology and skin barrier defect in mice carrying a Stargardt disease-3 mutation in elongase of very long chain fatty acids-4. Mol Vis 13:258-72. [PubMed: 17356513] [MGI Ref ID J:121481]
Montavon T; Soshnikova N; Mascrez B; Joye E; Thevenet L; Splinter E; de Laat W; Spitz F; Duboule D. 2011. A regulatory archipelago controls hox genes transcription in digits. Cell 147(5):1132-45. [PubMed: 22118467] [MGI Ref ID J:178930]
Montavon T; Thevenet L; Duboule D. 2012. Impact of copy number variations (CNVs) on long-range gene regulation at the HoxD locus. Proc Natl Acad Sci U S A 109(50):20204-11. [PubMed: 23134724] [MGI Ref ID J:192248]
Muzumdar MD; Luo L; Zong H. 2007. Modeling sporadic loss of heterozygosity in mice by using mosaic analysis with double markers (MADM). Proc Natl Acad Sci U S A 104(11):4495-500. [PubMed: 17360552] [MGI Ref ID J:120052]
Muzumdar MD; Tasic B; Miyamichi K; Li L; Luo L. 2007. A global double-fluorescent Cre reporter mouse. Genesis 45(9):593-605. [PubMed: 17868096] [MGI Ref ID J:124702]
Nichol PF; Botham R; Saijoh Y; Reeder AL; Zaremba KM. 2011. A more efficient method to generate null mutants using Hprt-Cre with floxed alleles. J Pediatr Surg 46(9):1711-9. [PubMed: 21929979] [MGI Ref ID J:190200]
Nishijo K; Hosoyama T; Bjornson CR; Schaffer BS; Prajapati SI; Bahadur AN; Hansen MS; Blandford MC; McCleish AT; Rubin BP; Epstein JA; Rando TA; Capecchi MR; Keller C. 2009. Biomarker system for studying muscle, stem cells, and cancer in vivo. FASEB J 23(8):2681-90. [PubMed: 19332644] [MGI Ref ID J:157754]
Reeder AL; Botham RA; Franco M; Zaremba KM; Nichol PF. 2012. Formation of intestinal atresias in the Fgfr2IIIb-/- mice is not associated with defects in notochord development or alterations in Shh expression. J Surg Res :. [PubMed: 22572615] [MGI Ref ID J:186261]
Stark KL; Xu B; Bagchi A; Lai WS; Liu H; Hsu R; Wan X; Pavlidis P; Mills AA; Karayiorgou M; Gogos JA. 2008. Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model. Nat Genet 40(6):751-60. [PubMed: 18469815] [MGI Ref ID J:136969]
Tang MC; Jacobs SA; Wong LH; Mann JR. 2013. Conditional allelic replacement applied to genes encoding the histone variant H3.3 in the mouse. Genesis 51(2):142-6. [PubMed: 23315948] [MGI Ref ID J:194069]
Tasic B; Miyamichi K; Hippenmeyer S; Dani VS; Zeng H; Joo W; Zong H; Chen-Tsai Y; Luo L. 2012. Extensions of MADM (Mosaic Analysis with Double Markers) in Mice PLoS ONE 7(3):e33332. [PubMed: 22479386] [MGI Ref ID J:181830]
Tschopp P; Duboule D. 2011. A regulatory 'landscape effect' over the HoxD cluster. Dev Biol 351(2):288-96. [PubMed: 21195707] [MGI Ref ID J:170557]
Tschopp P; Fraudeau N; Bena F; Duboule D. 2011. Reshuffling genomic landscapes to study the regulatory evolution of Hox gene clusters. Proc Natl Acad Sci U S A 108(26):10632-7. [PubMed: 21670281] [MGI Ref ID J:173547]
Urness LD; Bleyl SB; Wright TJ; Moon AM; Mansour SL. 2011. Redundant and dosage sensitive requirements for Fgf3 and Fgf10 in cardiovascular development. Dev Biol 356(2):383-97. [PubMed: 21664901] [MGI Ref ID J:175465]
Urness LD; Paxton CN; Wang X; Schoenwolf GC; Mansour SL. 2010. FGF signaling regulates otic placode induction and refinement by controlling both ectodermal target genes and hindbrain Wnt8a. Dev Biol 340(2):595-604. [PubMed: 20171206] [MGI Ref ID J:160254]
Wang Y; Yin X; Rosen G; Gabel L; Guadiana SM; Sarkisian MR; Galaburda AM; Loturco JJ. 2011. Dcdc2 knockout mice display exacerbated developmental disruptions following knockdown of doublecortin. Neuroscience 190:398-408. [PubMed: 21689730] [MGI Ref ID J:175635]
Wang Z; Kumamoto Y; Wang P; Gan X; Lehmann D; Smrcka AV; Cohn L; Iwasaki A; Li L; Wu D. 2009. Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5. J Biol Chem 284(42):28599-606. [PubMed: 19713215] [MGI Ref ID J:157812]
Welsh M; Saunders PT; Atanassova N; Sharpe RM; Smith LB. 2009. Androgen action via testicular peritubular myoid cells is essential for male fertility. FASEB J 23(12):4218-30. [PubMed: 19692648] [MGI Ref ID J:155167]
Whitehead KJ; Chan AC; Navankasattusas S; Koh W; London NR; Ling J; Mayo AH; Drakos SG; Marchuk DA; Davis GE; Li DY. 2009. The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases. Nat Med 15(2):177-84. [PubMed: 19151728] [MGI Ref ID J:146527]
Winnicka B; O'Conor C; Schacke W; Vernier K; Grant CL; Fenteany FH; Pereira FE; Liang B; Kaur A; Zhao R; Montrose DC; Rosenberg DW; Aguila HL; Shapiro LH. 2010. CD13 is dispensable for normal hematopoiesis and myeloid cell functions in the mouse. J Leukoc Biol 88(2):347-59. [PubMed: 20430777] [MGI Ref ID J:163945]
Wu S; Ying G; Wu Q; Capecchi MR. 2007. Toward simpler and faster genome-wide mutagenesis in mice. Nat Genet 39(7):922-30. [PubMed: 17572674] [MGI Ref ID J:123007]
Xu D; Liu X; Yu WM; Meyerson HJ; Guo C; Gerson SL; Qu CK. 2011. Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells. J Exp Med 208(10):1977-88. [PubMed: 21930766] [MGI Ref ID J:177285]
Yamamoto M; Shook NA; Kanisicak O; Yamamoto S; Wosczyna MN; Camp JR; Goldhamer DJ. 2009. A multifunctional reporter mouse line for Cre- and FLP-dependent lineage analysis. Genesis 47(2):107-14. [PubMed: 19165827] [MGI Ref ID J:147304]
Yamamoto M; Watt CD; Schmidt RJ; Kuscuoglu U; Miesfeld RL; Goldhamer DJ. 2007. Cloning and characterization of a novel MyoD enhancer-binding factor. Mech Dev 124(9-10):715-28. [PubMed: 17693064] [MGI Ref ID J:125184]
Zhou Y; Holmseth S; Guo C; Hassel B; Hofner G; Huitfeldt HS; Wanner KT; Danbolt NC. 2012. Deletion of the gamma-aminobutyric acid transporter 2 (GAT2 and SLC6A13) gene in mice leads to changes in liver and brain taurine contents. J Biol Chem 287(42):35733-46. [PubMed: 22896705] [MGI Ref ID J:191581]
Health & husbandry
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Health & Colony Maintenance Information
Animal Health Reports
Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.Colony Maintenance
Breeding & Husbandry This strain originated and is maintained on a 129S1 background. When mating a heterozygous female to a hemizygous male, heterozygous and homozygous females, and wiltype and hemizygous males result.
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $2250.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Embryos
Price (US dollars $) Frozen Embryo $1600.00 Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
- Cryopreserved Embryos
Available to most shipping destinations1
This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.
1 Shipments cannot be made to Australia due to Australian government import restrictions.
2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.- Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
| Pricing for International shipping destinations |
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Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $2925.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Embryos
Price (US dollars $) Frozen Embryo $2080.00 Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
- Cryopreserved Embryos
Available to most shipping destinations1
This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.
1 Shipments cannot be made to Australia due to Australian government import restrictions.
2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.- Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
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Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| Wild-type female from the colony | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
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The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.