Strain Name: |
NOD.CBALs-Tyr+/LtJ |
|---|---|
Stock Number: |
004304 |
Availability: | Repository-Cryopreserved |
Price and Supply Information | |
General Terms and Conditions |
| Former Name |
NOD.CBALs-Tyr+/Lt (Changed: 12-JUL-05
) |
| Genes & Alleles | Tyr; Tyr+; |
Product Information
Strain Details
Type JAX® GEMM® Strain - Congenic Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Mutant Strain Species laboratory mouse Background Strain NOD/ShiLt Donor Strain CBA/JLsLt via CBcNO6 Donating Investigator Edward Leiter, The Jackson Laboratory H2 Haplotype g7 Appearance
agouti
Related Genotype: A/A Tyr/TyrStrain Description
This Chr 7 congenic strain in which the tyrosinase allele Tyr+ of the CBA/JLsLt strain is fixed on the NOD/Lt background, therefore making the strain agouti in color. This strain should be a good donor for blastocysts in which to microinject targeted NOD ES cells, and may alleviate unwanted genome integration experienced with use of the C57BL/6 blastocysts. The congenic segment on Chr 7 slightly supresses spontaneous T1D development which is an asset when these females are used as blastocyst recipients.Strain Development
A CBcNO6/Lt (Stock# 2349) derived, Chr 7 genomic segment containing Tyr+ and extending from D7Mit250 to D7Mit66 was transferred to NOD/Lt for 9 generations. Marker assisted analysis indicates all known Idd are of NOD/Lt origin. In 2005, NOD.CBALs-Tyr+/Lt was transfered to the Type 1 Diabetes Resource at The Jackson Laboratory.
Gene & Allele Details
| Allele Symbol | Tyr+ | ||
|---|---|---|---|
| Allele Name | wild type | ||
| Gene Symbol and Name | Tyr, tyrosinase | ||
| Chromosome | 7 | ||
| Gene Common Name(s) | C; OCA1A; OCAIA; SHEP3; albino; c; skc35; skin/coat color 35; | ||
Control Information
| Control | ||
|---|---|---|
| 001976 NOD/ShiLtJ | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for JAX® GEMM® Strains | ||
Colony Maintenance
| Diet Information | LabDiet® 5K52/5K67 |
|---|
Related Strains
Strains carrying Tyr+ allele
000090 129S1/Sv-Oca2+ Tyr+ KitlSl-J/J 005445 A.B6 Tyr+-Cybanmf333/J 005012 A.B6 Tyr+-Myo5ad-l31J/J 002565 A.B6-Tyr+/J 000822 B6 x 129S1/SvEi Oca2+ Tyr+-Vsx2or-J/J 000899 C.B6-Tyr+ Hbbs/J 000494 J.Cg-Oca2+ Tyr+ Lystbg/J 002281 NFS.C58-Tyr+/J View Strains carrying Tyr+ (8 strains)
Additional Web Information
Congenic Nomenclature
Research Applications
This mouse can be used to support research in many areas including:
Tyr+ relatedDiabetes and Obesity Research
Type 1 Diabetes (IDDM) Analysis Strains (NOD/ShiLtJ Non-MHC Congenics)
Immunology and Inflammation Research
Autoimmunity (Type 1 Diabetes)
Dermatology Research
Color and White Spotting Defects (oculocutaneous albinism, type I)
Mouse/Human Gene Homologs
albinism, tyrosine negative (wildtype)
References
Selected Reference(s)
Additional ReferencesChen J; Reifsnyder PC; Scheuplein F; Schott WH; Mileikovsky M; Soodeen-Karamath S; Nagy A; Dosch MH; Ellis J; Koch-Nolte F; Leiter EH. 2005. 'Agouti NOD': identification of a CBA-derived Idd locus on Chromosome 7 and its use for chimera production with NOD embryonic stem cells. Mamm Genome 16(10):775-83. [PubMed: 16261419] [MGI Ref ID J:102639]
Price and Supply Information
| Strain Name: | NOD.CBALs-Tyr+/LtJ |
| Stock Number: | 004304 |
Price Details
IMPORTANT NOTE: Prices are based on shipping destination. The shipping destinations are:
- USA, Canada and Mexico
- International
*Pricing for Shipping Destination selected:
International
| Price(s) in US dollars ($) | |||||
|---|---|---|---|---|---|
| Cryorecovery Fee | $2470.00 | ||||
Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below |
| Control Information | View Control Information in Strain Details. View Control Pricing Information for JAX® Strains. |
General Terms and Conditions
View JAX® Mice & Services Conditions of Use.
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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