Strain Name: |
NOD.CBALs-Hc1/LtJ |
|---|---|
Stock Number: |
004306 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Former Name |
NOD.CBALs-Hc1/Lt (Changed: 06-SEP-06
) |
|
NOD.CBALs-Hc1 (Changed: 20-JAN-05
) | |
| Strain Common Names | NOD.Hc1; |
| Genes & Alleles | Hc; Hc1; |
Type JAX® GEMM® Strain - Congenic Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Mutant Strain Species laboratory mouse Background Strain NOD/ShiLt Donor Strain CBA/JLsLt Donating Investigator Edward Leiter, The Jackson Laboratory H2 Haplotype g7 Generation N10F13p Appearance
albino, pink eyed
Related Genotype: A/A Tyrc/TyrcStrain Description
This NOD/Lt congenic strain is carrying Chr 2 alleles derived from CBA/Ls including Hc1. Diabetes onset and incidence is the same as NOD/Lt.Strain Development
C5 hemolytic complement located on Chr. 2 was transfered from CBA/Ls to NOD/Lt for 10 generations replacing the defective Hc0 allele expressed in NOD/Lt. In 2006, the T1DR received homozygous NOD.CBALs-Hc1/Lt at generation N10F11.
| Allele Symbol | Hc1 | ||
|---|---|---|---|
| Allele Name | sufficient | ||
| Common Name(s) | C5 sufficient; C5-s; C5-suf; | ||
| Gene Symbol and Name | Hc, hemolytic complement | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | C5; C5a; CPAMD4; FLJ17816; FLJ17822; He; MGC142298; RGD1561905; | ||
| General Note |
Hc was identified as a candidate gene for Abhr2 in a microarray analysis of lung mRNA from A/J, C3H/HeJ, and (A/J x C3H/HeJ)F1 x A/J backcross animals. Hc genotype shows statistically significant correlation to allergen-induced bronchial hyperresponsive phenotype. The C3H/HeJ allele does not have the 2 bp deletion and is associated with resistance to allergen-induced bronchial hyperresponsiveness. (J:108211) | ||
| Molecular Note | This allele does not contain the 2 base "TA" deletion found in the Hc0 allele and is found in the following mouse strains BALB/cJ, C57BL/6J, DBA/1J, and B10.D2/nSnJ. This is equivalent to the wild-type allele. [J:23983] | ||
| Control | ||
|---|---|---|
| 001976 NOD/ShiLtJ | ||
| Considerations for Choosing Controls | ||
Strains carrying Hc1 allele
000470 AK.M-H2m H2-T18a/nSnJ 005308 B10.Cg-H2d Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ 000463 B10.D2-Hc1 H2d H2-T18c/nSnJ 003147 B10.D2-Hc1 H2d H2-T18c/nSnJ-Tg(DO11.10)10Dlo/J View Strains carrying Hc1 (4 strains)
Strains carrying other alleles of Hc
000645 A/HeJ 000646 A/J 000647 A/WySnJ 000648 AKR/J 000460 B10.D2-Hc0 H2d H2-T18c/o2SnJ 000461 B10.D2-Hc0 H2d H2-T18c/oSnJ 000657 CE/J 000671 DBA/2J 007048 DBA/2J-Gpnmb+/SjJ 001800 FVB/NJ 001491 FVB/NMob 000674 I/LnJ 001303 NOD.CB17-Prkdcscid/J 001976 NOD/ShiLtJ 000684 NZB/BlNJ 000682 RF/J 000688 ST/bJ 000689 SWR/J View Strains carrying other alleles of Hc (18 strains)
Congenic Nomenclature
Hc1 relatedDiabetes and Obesity Research
Type 1 Diabetes (IDDM) Analysis Strains (NOD/ShiLtJ Non-MHC Congenics)
Research Tools
Diabetes and Obesity Research
Immunology and Inflammation Research
Immunology and Inflammation Research
Immunodeficiency (specific complement deficiency) (control)
Research Tools
Immunology and Inflammation Research (specific complement deficiency) (C5 complement) (control)
Selected Reference(s)
Additional ReferencesChen J; Reifsnyder PC; Scheuplein F; Schott WH; Mileikovsky M; Soodeen-Karamath S; Nagy A; Dosch MH; Ellis J; Koch-Nolte F; Leiter EH. 2005. 'Agouti NOD': identification of a CBA-derived Idd locus on Chromosome 7 and its use for chimera production with NOD embryonic stem cells. Mamm Genome 16(10):775-83. [PubMed: 16261419] [J:102639]
| Strain Name: | NOD.CBALs-Hc1/LtJ |
| Stock Number: | 004306 |
IMPORTANT NOTE: Prices are based on shipping destination. To view prices, select your shipping destination.
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to the Supply Notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below |
| Control Information | View Control Information in Strain Details. |
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