Strain Name:


Stock Number:


Order this mouse


Level 4

Use Restrictions Apply, see Terms of Use
Common Names: Il-10 KO;     IL-10 KO;    
This strain represents a genetic mouse model of inflammatory bowel disease (IBD) where stable inflammatory lesions in the cecum and colon are present by six to seven weeks of ages. The mice carry a targeted mutation of the interleukin 10 gene, one of several genes whose disruption induces IBD. Evidence from several publications suggests that the enteric flora of the mice contributes significantly to the presentation of the IBD-like phenotype. Our colony is maintained in isolators under conditions which preserve the presence of potentially strain-unique enteric flora required for the development of IBD.


Strain Information

Type Congenic; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Breeding Considerations This strain is a challenging breeder.
Specieslaboratory mouse
Background Strain C3H/HeJBir
Donor Strain 129P2/OlaHsd via B6.129P2-Il10tm1Cgn
H2 Haplotypek
GenerationN15F15 (21-FEB-06)
Generation Definitions

Related Genotype: A/A

Important Note
This strain is homozygous for Pde6brd1 and Tlr4Lps-d.

Mice homozygous for the Il10tm1Cgn targeted mutation are viable and fertile when housed under specific pathogen free (SPF) conditions. Under conventional housing conditions, Il10-deficiency is associated with altered lymphocyte and myeloid profiles, elevated serum amyloid A levels, altered responses to inflammatory or autoimmune stimuli (both endogenous and induced), increased prevalence of colorectal adenocarcinoma (especially on 129/Sv and, to a lesser extent, BALB/c genetic background), and spontaneous development of chronic enterocolitis (see below). As The Jackson Laboratory Repository maintains these mice at high health status conditions (high SPF), the observed or experimentally-induced Il10-deficient phenotype may vary from that previously published using mice from conventional mouse rooms. These IL-10 mutant mice may be useful studying inflammatory bowel disease (IBD) (Crohn's disease (CD) and/or colitis), cancer, innate and adaptive immunity, and many other areas of inflammatory or autoimmunity research.

The onset and severity of both spontaneous and experimentally-induced inflammatory phenotype of Il10-deficient mice is strongly influenced by the genetic background and the husbandry conditions (specific health status/commensal flora) of the vivaria in which mice are maintained.

For example, inflammatory bowel disease (IBD; colitis and Crohn's disease) severity in mouse models is dependent upon interactions between specific genetic background and environmental factors (an as yet undefined component of the enteric flora of which Helicobacter spp. appear to be associated, but not specifically the environmental trigger). Both spontaneous and induced models of IBD demonstrate that susceptibility to intestinal inflammation varies markedly among inbred strains of mice. Generally, for Il10-deficient models on defined genetic backgrounds, the severity of colitis-related characteristics is most severe on C3H/HeJBir (Stock No. 004326 and Stock No. 003968) or 129/Sv (Stock No. 004368), intermediate on BALB/cJ (Stock No. 004333) or NOD/Lt (Stock No. 004266), and least severe on C57BL/10 (Stock No. 002250) or C57BL/6J (Stock No. 002251). Furthermore, the husbandry conditions (specific health status/commensal flora) of the vivaria in which mice are maintained significantly alter the onset and severity of spontaneous IBD; higher SPF conditions are associated with attenuated colitis. Il10-deficient mice on both the C3H/HeJBir and C57BL/6J genetic backgrounds exhibit a significant increase in peripheral blood granulocyte populations upon lesion development and this metric may be used as a robust non-lethal assessment of Il10-deficiency induced colitis onset and severity. Other indications of Il10-deficiency induced colitic lesion onset may include perianal ulceration (C3H/HeJBir background) or rectal prolapse (C57BL/6J background).

For a more detailed description please refer to the JAX Notes Fall 1997 article.

Important Health Status Considerations

Our colony of these Il10-deficient mice is maintained under conditions which preserve the presence of potentially strain-unique enteric flora required for the development of inflammatory bowel disease (IBD). This includes the presence of Helicobacter spp., which is a marker for the presence of the additional microbiota required for colitis development.

For additional information, please view the following: Important Health Status Advisory.

The Il10tm1Cgn mutation was created by in the Laboratory of Dr. Werner Muller at the University of Cologne. Briefly, a targeting vector was designed to replace codons 5-55 of exon 1 of the targeted gene with a 24 bp linker (providing a termination codon) and a neo expression cassette, as well as introduce a termination codon into exon 3. The construct was electroporated into 129P2/OlaHsd-derived E14-1 embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient C57BL/6 blastocysts and chimeric males were bred with C57BL/6 females to establish the mutant colony on a mixed B6;129P2 genetic background. It was then imported to the Induced Mutant Resource at The Jackson Labratory in 1995. Subsequently, mutant mice were backcrossed to C3H/HeJBir for at least 10 generations. At the tenth backcross generation to C3H/HeJBir, heterozygotes were intercrossed to produce founders for this homozygous mutant line (Stock No. 004326) as well as founders for a wildtype control line (Stock No. 005973).

Control Information

   005973 C3Bir.129P2(B6)-Il10C3Bir/LtJ This strain is in cryopreservation. For most research applications the approximate control, C3H/HeJ (#000659), will be acceptable, please contact our technical support if you require assistance.
   000659 C3H/HeJ (approximate)
   005972 C3H/HeJBirLtJ (approximate) This strain is in cryopreservation. For most research applications the approximate control, C3H/HeJ (#000659), will be acceptable, please contact our technical support if you require assistance.
  Considerations for Choosing Controls

Related Strains

View Strains carrying   Il10tm1Cgn     (10 strains)

Strains carrying   Pde6brd1 allele
004202   B6.C3 Pde6brd1 Hps4le/+ +-Lmx1adr-8J/J
000002   B6.C3-Pde6brd1 Hps4le/J
001022   B6C3FeF1/J a/a
000652   BDP/J
000653   BUB/BnJ
002439   C3.129P2(B6)-B2mtm1Unc/J
005494   C3.129S1(B6)-Grm1rcw/J
000509   C3.Cg-Lystbg-2J/J
000480   C3.MRL-Faslpr/J
001957   C3A Pde6brd1.O20/A-Prph2Rd2/J
003968   C3Bir.129P2(B6)-Il10tm1Cgn/LtJ
006435   C3Fe.SW-Soaa/MonJ
001904   C3H-Atcayji-hes/J
000659   C3H/HeJ
000511   C3H/HeJ-Ap3d1mh-2J/J
000784   C3H/HeJ-Faslgld/J
002433   C3H/HeJ-Sptbn4qv-lnd2J/J
005972   C3H/HeJBirLtJ
001824   C3H/HeJSxJ
000635   C3H/HeOuJ
000474   C3H/HeSn
001431   C3H/HeSn-ocd/J
000661   C3H/HeSnJ
002333   C3H/HeSnJ-gri/J
001576   C3He-Atp7btx-J/J
000658   C3HeB/FeJ
002588   C3HeB/FeJ-Eya1bor/J
001533   C3HeB/FeJ-Mc1rE-so Gli3Xt-J/J
001908   C3HfB/BiJ
001502   C3Sn.B6-Epha4rb/EiGrsrJ
002235   C3Sn.C3-Ctnna2cdf/J
001547   C3Sn.Cg-Cm/J
001906   C3fBAnl.Cg-Catb/AnlJ
000656   CBA/J
000813   CBA/J-Atp7aMo-pew/J
000660   DA/HuSnJ
000023   FL/1ReJ
000025   FL/4ReJ
003024   FVB.129P2(B6)-Fmr1tm1Cgr/J
002539   FVB.129P2-Abcb4tm1Bor/J
002935   FVB.129S2(B6)-Ccnd1tm1Wbg/J
002953   FVB.Cg-Tg(MMTVTGFA)254Rjc/J
003170   FVB.Cg-Tg(Myh6-tTA)6Smbf/J
003078   FVB.Cg-Tg(WapIgf1)39Dlr/J
003487   FVB.Cg-Tg(XGFAP-lacZ)3Mes/J
003257   FVB/N-Tg(GFAPGFP)14Mes/J
002856   FVB/N-Tg(TIE2-lacZ)182Sato/J
002384   FVB/N-Tg(UcpDta)1Kz/J
001800   FVB/NJ
001491   FVB/NMob
000804   HPG/BmJ
000734   MOLD/RkJ
000550   MOLF/EiJ
002423   NON/ShiLtJ
000679   P/J
000680   PL/J
000268   RSV/LeJ
000269   SB/LeJ
010968   SB;C3Sn-Lrp4mdig-2J/GrsrJ
005651   SJL.AK-Thy1a/TseJ
000686   SJL/J
000688   ST/bJ
004808   STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
002648   STOCK a/a Cln6nclf/J
000279   STOCK gr +/+ Ap3d1mh/J
005965   STOCK Tg(Pomc1-cre)16Lowl/J
004770   SW.B6-Soab/J
002023   SWR.M-Emv21 Emv22/J
000689   SWR/J
000939   SWR/J-Clcn1adr-mto/J
000692   WB/ReJ KitW/J
100410   WBB6F1/J-KitW/KitW-v/J
000693   WC/ReJ KitlSl/J
View Strains carrying   Pde6brd1     (73 strains)

Strains carrying   Tlr4Lps-d allele
002930   C.C3-Tlr4Lps-d/J
005973   C3Bir.129P2(B6)-Il10C3Bir/LtJ
003968   C3Bir.129P2(B6)-Il10tm1Cgn/LtJ
000659   C3H/HeJ
005972   C3H/HeJBirLtJ
View Strains carrying   Tlr4Lps-d     (5 strains)

Strains carrying other alleles of Il10
014530   B6(Cg)-Il10tm1.1Karp/J
008379   B6.129S6-Il10tm1Flv/J
005973   C3Bir.129P2(B6)-Il10C3Bir/LtJ
View Strains carrying other alleles of Il10     (3 strains)

View Strains carrying other alleles of Pde6b     (15 strains)

Strains carrying other alleles of Tlr4
024872   B6(Cg)-Tlr4tm1.1Karp/J
007227   B6.B10ScN-Tlr4lps-del/JthJ
000029   BXD29-Tlr4lps-2J/J
003752   C57BL/10ScNJ
View Strains carrying other alleles of Tlr4     (4 strains)

Additional Web Information

JAX® NOTES, Fall 1997; 471. Il10tm1Cgn, an Interleukin-10 Gene Targeted Mutation.


Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
Models with phenotypic similarity to human diseases where etiology is unknown or involving genes where ortholog is unknown.
Inflammatory Bowel Disease 23; IBD23
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Graft-Versus-Host Disease, Susceptibility To; GVHDS   (IL10)
Human Immunodeficiency Virus Type 1, Susceptibility to   (IL10)
Rheumatoid Arthritis; RA   (IL10)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.


        involves: 129P2/OlaHsd * C57BL/6
  • mortality/aging
  • premature death
    • ~30% of homozygotes succumb to disease within 3 months of age   (MGI Ref ID J:15222)
    • death is correlated with anemia and gradual weight loss   (MGI Ref ID J:15222)
    • at >3 months of age, mortality is increased but never reaches 100%   (MGI Ref ID J:15222)
  • digestive/alimentary phenotype
  • abnormal intestinal epithelium morphology   (MGI Ref ID J:15222)
    • abnormal enterocyte morphology   (MGI Ref ID J:15222)
    • abnormal intestinal mucosa morphology   (MGI Ref ID J:15222)
      • at 9 weeks, 59% of mice displaying colitis develop a high grade dysplasia of the colonic mucosa   (MGI Ref ID J:68476)
      • abnormal crypts of Lieberkuhn morphology   (MGI Ref ID J:15222)
  • abnormal large intestine morphology
    • minimal epithelial hyperplasia at 3 weeks   (MGI Ref ID J:35020)
    • prominent epithelial hyperplasia at 3 months   (MGI Ref ID J:35020)
    • abnormal colon morphology
      • colonic prolapse is observed in some older mutants   (MGI Ref ID J:107077)
  • intestinal inflammation   (MGI Ref ID J:35020)
    • anemic and underweight homozygotes display enterocolitis involving the entire intestinal tract, duodenum, proximal jejunum, and proximal colon   (MGI Ref ID J:15222)
    • inflammation was limited to the proximal colon under specific pathogen free conditions   (MGI Ref ID J:15222)
    • spontaneous inflammatory bowel disease (IBD) develops by 5 weeks in some animals   (MGI Ref ID J:107077)
    • large intestinal inflammation
      • lymphocytes and small numbers of neutrophiles as infiltrates in the lamina propria of the cecum, ascending and transverse colon at three weeks   (MGI Ref ID J:35020)
      • multifocal lesions in all regions of the large intestine at three months   (MGI Ref ID J:35020)
      • occasional transmural inflammation and crypt abscesses at 3 months   (MGI Ref ID J:35020)
      • more ulcerations at 6 months   (MGI Ref ID J:35020)
      • cecum inflammation   (MGI Ref ID J:35020)
      • colitis
        • all Il10-null mice develop colitis by the age of 9 weeks in contrast to wild-type littermates   (MGI Ref ID J:68476)
    • small intestinal inflammation
      • 8% with duodenitis at 3 months of age   (MGI Ref ID J:35020)
      • increased duodenitis at 6 months   (MGI Ref ID J:35020)
  • growth/size/body region phenotype
  • cachexia
    • although some homozygotes with slow disease progression show normal body weights up to 12 weeks of age, all homozygotes are eventually affected by weight loss   (MGI Ref ID J:15222)
    • at 7-11 weeks of age, most homozygotes display a ~30% weight reduction relative to wild-type controls   (MGI Ref ID J:15222)
  • postnatal growth retardation
    • at 7-11 weeks of age, ~75% of homozygotes are growth retarded relative to wild-type controls   (MGI Ref ID J:15222)
    • growth retardation is first observed between 3 and 4 weeks of age   (MGI Ref ID J:15222)
  • hematopoietic system phenotype
  • abnormal leukocyte morphology   (MGI Ref ID J:35020)
    • abnormal lymphocyte cell number
      • double control levels in the lamina propria   (MGI Ref ID J:35020)
      • increased CD4-positive, alpha beta T cell number
        • elevated   (MGI Ref ID J:35020)
        • activated memory phenotype   (MGI Ref ID J:35020)
    • increased granulocyte number
      • homozygotes display up to a 2-fold elevation in leukocyte numbers due to an increase in granulocytes   (MGI Ref ID J:15222)
      • elevated at 3 weeks and increasing with age   (MGI Ref ID J:35020)
  • abnormal level of surface class II molecules   (MGI Ref ID J:15222)
  • abnormal myelopoiesis
    • severely anemic homozygotes display a hyperproliferative myeloid compartment   (MGI Ref ID J:15222)
  • absent erythroid progenitor cell
    • severely anemic homozygotes show complete depletion of eythroid cells in the bone marrow   (MGI Ref ID J:15222)
  • anemia
    • at 7-11 weeks of age, ~90% of homozygotes exhibit anemia, most likely due to iron deficiency   (MGI Ref ID J:15222)
    • the observed anemia is most often defined as microcytic or normocytic and hypochromic   (MGI Ref ID J:15222)
    • hypochromic anemia   (MGI Ref ID J:15222)
    • microcytic anemia   (MGI Ref ID J:15222)
  • decreased T cell proliferation
    • reduced proliferative response of CD4+ cells to UVB irradiation   (MGI Ref ID J:125760)
  • decreased erythrocyte cell number
    • at 7-11 weeks of age, ~90% of homozygotes display decreased erythrocyte numbers relative to wild-type controls   (MGI Ref ID J:15222)
  • decreased hemoglobin content
    • at 7-11 weeks of age, ~90% of homozygotes display a reduced hemoglobin concentration in circulating blood   (MGI Ref ID J:15222)
  • decreased spleen iron level   (MGI Ref ID J:15222)
  • decreased spleen red pulp amount
    • severely anemic homozygotes display hypoplasia of the splenic red pulp   (MGI Ref ID J:15222)
  • increased IgE level
    • total IgE levels are more than 7-fold higher and serum levels of OVA-specific IgE more than 2-fold higher than in wild-type mice after ovalbumin challenge   (MGI Ref ID J:62283)
  • increased IgG1 level
    • OVA-specific IgG1 levels are higher in ovalbumin-sensitized mutants   (MGI Ref ID J:62283)
  • increased IgG2a level
    • OVA-specific IgG2a levels are higher in ovalbumin-sensitized mutants   (MGI Ref ID J:62283)
  • increased thymus weight
    • increases with time and IBD   (MGI Ref ID J:107077)
  • thymus hyperplasia
    • increases with time and IBD   (MGI Ref ID J:107077)
  • immune system phenotype
  • *normal* immune system phenotype   (MGI Ref ID J:107077)
    • B and T lymphocytes develop normally at 4-6 weeks of age, young homozygotes exhibit normal CD4+ and CD8+ T subsets in thymus and spleen as well as normal B cell subsets in bone marrow, spleen and peritoneum relative to wild-type controls   (MGI Ref ID J:15222)
    • young homozygotes show a normal antibody response to alpha (1-3)-dextrane, suggesting a normal B-1 cell subset in the peritoneum   (MGI Ref ID J:15222)
    • young homozygotes display normal antibody production and development of B cell memory in response to T cell-dependent immunization with haptenated chicken gamma-globulin   (MGI Ref ID J:15222)
    • abnormal immune system physiology   (MGI Ref ID J:35020)
      • abnormal Langerhans cell physiology
        • greater numbers of cells migrate to lymph nodes after hapten exposure   (MGI Ref ID J:51636)
      • abnormal cytokine level   (MGI Ref ID J:35020)
        • abnormal interferon level
          • IFNgamma is expressed in colon in mice with minor IBD symptoms   (MGI Ref ID J:107077)
          • increased interferon gamma in the colon   (MGI Ref ID J:35020)
          • elevated amounts of IFN gamma produced by irradiated CD4+ cells   (MGI Ref ID J:125760)
        • abnormal interleukin level
          • Il-2, but not Il-1beta is expressed in colon in mice with minor IBD symptoms   (MGI Ref ID J:107077)
          • production of IL1 alpha is 3-4 times higher than controls 24 hours after LPS stimulation   (MGI Ref ID J:51636)
          • increased IL 1 alpha, IL6, in the colon   (MGI Ref ID J:35020)
          • reduced IL4 production by irradiated CD4+ cells   (MGI Ref ID J:35020)
        • abnormal tumor necrosis factor level
          • TNFalpha is expressed in colon in mice with minor IBD symptoms   (MGI Ref ID J:107077)
          • production of TNF alpha is 3-4 times higher than controls 24 hours after LPS stimulation   (MGI Ref ID J:51636)
          • increased TNF alpha in the colon   (MGI Ref ID J:35020)
      • abnormal level of surface class II molecules   (MGI Ref ID J:15222)
      • abnormal response to infection
        • upon infection with the nematode N. brasiliensis, homozygotes develop a Th1 response in addition to the expected nematode-induced Th2 response, as shown by a 5-fold increase in IFN-gamma levels in culture supernatants of Con A-stimulated spleen cells   (MGI Ref ID J:15222)
        • increased susceptibility to parasitic infection
          • time to death induced by exposure to Plasmodium falciparum is decreased compared to in wild-type mice (7+/-0 days compared to 7.8+/-0.2 days, respectively)   (MGI Ref ID J:123927)
          • in mice depleted of regulatory T cells, experimental cerebral malaria is delayed following exposure to Plasmodium falciparum but disease progression occurs unlike in wild-type mice similarly treated   (MGI Ref ID J:123927)
      • abnormal type IV hypersensitivity reaction
        • blockage of delayed-type hypertension by midrange UV radiation is prevented   (MGI Ref ID J:35510)
        • increased susceptibility to type IV hypersensitivity reaction
          • enhanced contact hypersensitivity to FITC   (MGI Ref ID J:51636)
      • chronic inflammation
        • enterocolitis involving the entire intestinal tract, duodenum, proximal jejunum, and proximal colon   (MGI Ref ID J:15222)
        • inflammation was limited to the proximal colon under specific pathogen free conditions   (MGI Ref ID J:15222)
      • decreased T cell proliferation
        • reduced proliferative response of CD4+ cells to UVB irradiation   (MGI Ref ID J:125760)
      • decreased length of allograft survival
        • significantly lower cardiac graft survival times   (MGI Ref ID J:44346)
      • increased IgE level
        • total IgE levels are more than 7-fold higher and serum levels of OVA-specific IgE more than 2-fold higher than in wild-type mice after ovalbumin challenge   (MGI Ref ID J:62283)
      • increased IgG1 level
        • OVA-specific IgG1 levels are higher in ovalbumin-sensitized mutants   (MGI Ref ID J:62283)
      • increased IgG2a level
        • OVA-specific IgG2a levels are higher in ovalbumin-sensitized mutants   (MGI Ref ID J:62283)
      • increased interferon-gamma secretion
        • upon infection with the nematode N. brasiliensis, homozygotes develop a Th1 response in addition to the expected nematode-induced Th2 response, as shown by a 5-fold increase in IFN-gamma levels in culture supernatants of Con A-stimulated spleen cells   (MGI Ref ID J:15222)
        • a similar increase in IFN-gamma production is found in cultures of anti-CD3-stimulated spleenic CD4+ T cells from nematode-infected homozygotes relative to infected controls   (MGI Ref ID J:15222)
      • intestinal inflammation   (MGI Ref ID J:35020)
        • anemic and underweight homozygotes display enterocolitis involving the entire intestinal tract, duodenum, proximal jejunum, and proximal colon   (MGI Ref ID J:15222)
        • inflammation was limited to the proximal colon under specific pathogen free conditions   (MGI Ref ID J:15222)
        • spontaneous inflammatory bowel disease (IBD) develops by 5 weeks in some animals   (MGI Ref ID J:107077)
        • large intestinal inflammation
          • lymphocytes and small numbers of neutrophiles as infiltrates in the lamina propria of the cecum, ascending and transverse colon at three weeks   (MGI Ref ID J:35020)
          • multifocal lesions in all regions of the large intestine at three months   (MGI Ref ID J:35020)
          • occasional transmural inflammation and crypt abscesses at 3 months   (MGI Ref ID J:35020)
          • more ulcerations at 6 months   (MGI Ref ID J:35020)
          • cecum inflammation   (MGI Ref ID J:35020)
          • colitis
            • all Il10-null mice develop colitis by the age of 9 weeks in contrast to wild-type littermates   (MGI Ref ID J:68476)
        • small intestinal inflammation
          • 8% with duodenitis at 3 months of age   (MGI Ref ID J:35020)
          • increased duodenitis at 6 months   (MGI Ref ID J:35020)
    • abnormal leukocyte morphology   (MGI Ref ID J:35020)
      • abnormal lymphocyte cell number
        • double control levels in the lamina propria   (MGI Ref ID J:35020)
        • increased CD4-positive, alpha beta T cell number
          • elevated   (MGI Ref ID J:35020)
          • activated memory phenotype   (MGI Ref ID J:35020)
      • increased granulocyte number
        • homozygotes display up to a 2-fold elevation in leukocyte numbers due to an increase in granulocytes   (MGI Ref ID J:15222)
        • elevated at 3 weeks and increasing with age   (MGI Ref ID J:35020)
    • abnormal myelopoiesis
      • severely anemic homozygotes display a hyperproliferative myeloid compartment   (MGI Ref ID J:15222)
    • decreased spleen iron level   (MGI Ref ID J:15222)
    • decreased spleen red pulp amount
      • severely anemic homozygotes display hypoplasia of the splenic red pulp   (MGI Ref ID J:15222)
    • increased thymus weight
      • increases with time and IBD   (MGI Ref ID J:107077)
    • thymus hyperplasia
      • increases with time and IBD   (MGI Ref ID J:107077)
  • tumorigenesis
  • decreased tumor incidence
    • CD8+ cells impart faster tumor rejection in hosts   (MGI Ref ID J:125760)
    • decreased incidence of tumors by UV induction
      • do not develop skin tumors in response to UVB (280-350nm) exposure, even after 1 year   (MGI Ref ID J:125760)
  • increased intestinal adenocarcinoma incidence
    • at 9 weeks, 13% of homozygotes have adenocarcinomas   (MGI Ref ID J:68476)
    • in 10-31 week old animals, there is a 65% incidence of colorectal carcinomas   (MGI Ref ID J:68476)
    • increased large intestine adenocarcinoma incidence
      • 25% with colorectal adenocarcinomas at 3 months   (MGI Ref ID J:35020)
      • higher incidence of colorectal cancer at 6 months but no metastasis to lymph nodes   (MGI Ref ID J:35020)
  • respiratory system phenotype
  • decreased airway responsiveness
    • mutants sensitized and challenged to ovalbumin (OVA) fail to develop airway hyper-responsiveness despite a significant eosinophilic airway inflammatory response   (MGI Ref ID J:62283)
    • mutants are hyporesponsive to electrical field stimulation of trachea smooth muscle after OVA aerosol challenge   (MGI Ref ID J:62283)
    • airway response to methacholine is reduced by 37%   (MGI Ref ID J:115459)
    • tracheal rings are less responsive to KCl   (MGI Ref ID J:115459)
    • less tension develops (restored by treatment with L-NAME)   (MGI Ref ID J:115459)
  • homeostasis/metabolism phenotype
  • abnormal homeostasis   (MGI Ref ID J:129479)
    • abnormal glucose homeostasis   (MGI Ref ID J:129479)
      • decreased circulating insulin level
        • plasma insulin levels are 55% lower than controls after an overnight fast following 6 weeks on a high fat diet   (MGI Ref ID J:129479)
      • increased insulin sensitivity
        • greater increase in insulin stimulated whole body glucose uptake when corrected for lower plasma insulin   (MGI Ref ID J:129479)
    • abnormal iron level
      • homozygotes display depleted iron stores in spleen and bone marrow   (MGI Ref ID J:15222)
      • decreased circulating iron level
        • homozygotes display a 50% reduction in serum iron levels relative to wild-type controls   (MGI Ref ID J:15222)
      • decreased spleen iron level   (MGI Ref ID J:15222)
    • abnormal lipid level   (MGI Ref ID J:129479)
      • decreased circulating cholesterol level
        • decreased cholesterol esters   (MGI Ref ID J:129479)
      • increased circulating cholesterol level
        • increased free cholesterol   (MGI Ref ID J:129479)
      • increased fatty acid level
        • basal free fatty acid levels are significantly increased   (MGI Ref ID J:129479)
      • increased leukotriene level
        • OVA-sensitized mutants exhibit higher eosinophil peroxidase and leukotriene levels in bronchoalveolar lavage fluid than wild-type mice   (MGI Ref ID J:62283)
      • increased liver triglyceride level
        • 54% increase in hepatic triglycerides relative to controls   (MGI Ref ID J:129479)
        • plasma triglycerides not elevated   (MGI Ref ID J:129479)
    • abnormal nitric oxide homeostasis
      • exhaled NO is significantly decreased   (MGI Ref ID J:115459)
    • abnormal protein level
      • increased phosphorylated protein kinase after insulin stimulation   (MGI Ref ID J:129479)
      • abnormal circulating protein level   (MGI Ref ID J:110238)
        • abnormal circulating enzyme level
          • higher levels of alanine:2-oxaloglutarate aminotransferase in plasma 8 hours after lipopolysaccharide treatment   (MGI Ref ID J:110238)
        • abnormal circulating serum albumin level
      • abnormal cytokine level   (MGI Ref ID J:35020)
        • abnormal interferon level
          • IFNgamma is expressed in colon in mice with minor IBD symptoms   (MGI Ref ID J:107077)
          • increased interferon gamma in the colon   (MGI Ref ID J:35020)
          • elevated amounts of IFN gamma produced by irradiated CD4+ cells   (MGI Ref ID J:125760)
        • abnormal interleukin level
          • Il-2, but not Il-1beta is expressed in colon in mice with minor IBD symptoms   (MGI Ref ID J:107077)
          • production of IL1 alpha is 3-4 times higher than controls 24 hours after LPS stimulation   (MGI Ref ID J:51636)
          • increased IL 1 alpha, IL6, in the colon   (MGI Ref ID J:35020)
          • reduced IL4 production by irradiated CD4+ cells   (MGI Ref ID J:35020)
        • abnormal tumor necrosis factor level
          • TNFalpha is expressed in colon in mice with minor IBD symptoms   (MGI Ref ID J:107077)
          • production of TNF alpha is 3-4 times higher than controls 24 hours after LPS stimulation   (MGI Ref ID J:51636)
          • increased TNF alpha in the colon   (MGI Ref ID J:35020)
    • decreased circulating creatinine level   (MGI Ref ID J:93577)
  • decreased physiological sensitivity to xenobiotic
    • airway response to methacholine is reduced by 37%   (MGI Ref ID J:115459)
  • enhanced wound healing
    • experimental wound is a 6 mm circular excision through the full thickness of the skin   (MGI Ref ID J:117053)
    • macroscopic wound closure is accelerated   (MGI Ref ID J:117053)
    • by day 3, density of vascular structures significantly increased   (MGI Ref ID J:117053)
    • earlier and more persistent influx of greater numbers of macrophage into wound   (MGI Ref ID J:117053)
    • fully epithelialized and scab lost by 7 days   (MGI Ref ID J:117053)
    • increased collagen content and advanced maturation and organization of collagen bundles at 14 days   (MGI Ref ID J:117053)
  • increased myocardial infarction size
    • 90% more necrosis after experimental ischemia and reperfusion than found in controls   (MGI Ref ID J:70292)
    • 60% more polymorphonuclear neutrophiles per unit area in mid-ventricular slices relative to controls   (MGI Ref ID J:70292)
  • endocrine/exocrine gland phenotype
  • abnormal crypts of Lieberkuhn morphology   (MGI Ref ID J:15222)
  • increased thymus weight
    • increases with time and IBD   (MGI Ref ID J:107077)
  • thymus hyperplasia
    • increases with time and IBD   (MGI Ref ID J:107077)
  • behavior/neurological phenotype
  • increased thermal nociceptive threshold
    • latency to paw-licking is significantly longer on a hot plate test   (MGI Ref ID J:119039)
  • cardiovascular system phenotype
  • abnormal placental labyrinth vasculature morphology
    • 26% increase in maternal blood space in the labyrinth   (MGI Ref ID J:113180)
    • fetal capillaries are normal   (MGI Ref ID J:113180)
  • increased myocardial infarction size
    • 90% more necrosis after experimental ischemia and reperfusion than found in controls   (MGI Ref ID J:70292)
    • 60% more polymorphonuclear neutrophiles per unit area in mid-ventricular slices relative to controls   (MGI Ref ID J:70292)
  • craniofacial phenotype
  • abnormal alveolar process morphology
    • 3 fold increase in alveolar bone loss at 30 weeks relative to mice at 6 and 16 weeks   (MGI Ref ID J:147935)
  • embryogenesis phenotype
  • abnormal placental labyrinth vasculature morphology
    • 26% increase in maternal blood space in the labyrinth   (MGI Ref ID J:113180)
    • fetal capillaries are normal   (MGI Ref ID J:113180)
  • increased placental labyrinth size
    • 37% increase in cross-sectional area   (MGI Ref ID J:113180)
  • limbs/digits/tail phenotype
  • short femur   (MGI Ref ID J:93577)
  • liver/biliary system phenotype
  • abnormal liver physiology
    • hepatic glucose production is reduced more than in controls   (MGI Ref ID J:129479)
    • increased hepatocyte apoptosis
      • increased response in liver 4 hours after lipopolysaccharide treatment   (MGI Ref ID J:110238)
  • increased liver triglyceride level
    • 54% increase in hepatic triglycerides relative to controls   (MGI Ref ID J:129479)
    • plasma triglycerides not elevated   (MGI Ref ID J:129479)
  • skeleton phenotype
  • abnormal skeleton morphology   (MGI Ref ID J:93577)
    • abnormal alveolar process morphology
      • 3 fold increase in alveolar bone loss at 30 weeks relative to mice at 6 and 16 weeks   (MGI Ref ID J:147935)
    • abnormal bone structure   (MGI Ref ID J:93577)
      • abnormal osteoblast differentiation
        • decreased osteoblast generation in primary bone marrow stromal culture   (MGI Ref ID J:93577)
        • 40% fewer mineralized bone-like nodules in bone marrow cell culture   (MGI Ref ID J:93577)
      • abnormal trabecular bone morphology
        • reduced trabecular bone surface   (MGI Ref ID J:93577)
        • decreased bone trabecula number
          • reduced trabecular number   (MGI Ref ID J:93577)
        • decreased trabecular bone mass
          • cancellous bone mass of the tibia significantly decreased   (MGI Ref ID J:93577)
          • trabecular bone further reduced in mice with colitis   (MGI Ref ID J:93577)
        • decreased trabecular bone thickness
          • reduced trabecular width   (MGI Ref ID J:93577)
      • decreased bone mineral content
        • significantly reduced femoral ash weight   (MGI Ref ID J:93577)
      • decreased compact bone mass
        • cortical bone mass reduced   (MGI Ref ID J:93577)
    • short femur   (MGI Ref ID J:93577)
  • abnormal skeleton physiology   (MGI Ref ID J:93577)
    • abnormal bone mineralization
      • cancellous mineral apposition rate and bone formation rate are reduced   (MGI Ref ID J:93577)
      • bone resorption is normal   (MGI Ref ID J:93577)
    • decreased bone strength
      • femora more fragile in mechanical load tests   (MGI Ref ID J:93577)
      • reduced stiffness of femora   (MGI Ref ID J:93577)
  • integument phenotype
  • increased thermal nociceptive threshold
    • latency to paw-licking is significantly longer on a hot plate test   (MGI Ref ID J:119039)
  • cellular phenotype
  • abnormal osteoblast differentiation
    • decreased osteoblast generation in primary bone marrow stromal culture   (MGI Ref ID J:93577)
    • 40% fewer mineralized bone-like nodules in bone marrow cell culture   (MGI Ref ID J:93577)
  • increased hepatocyte apoptosis
    • increased response in liver 4 hours after lipopolysaccharide treatment   (MGI Ref ID J:110238)


        involves: 129P2/OlaHsd
  • reproductive system phenotype
  • abnormal reproductive system physiology
    • mice treated with Gal1 exhibit less protection from stress-induced fetal loss compared to similarly treated wild-type mice   (MGI Ref ID J:130208)
  • immune system phenotype
  • abnormal cytokine secretion
    • 6 hours after LPS injection, TNF, Il12 and Ifng levels are substantially higher than in controls   (MGI Ref ID J:117122)
  • abnormal inflammatory response
    • after three subcutaneous injections of LPS into the flank, mice develop solid subcutaneous swellings whereas wild-type do not   (MGI Ref ID J:117122)
    • lesion is associated with infiltration of macrophages and neutrophils, edema, and extensive necrosis of dermal, epidermal, and muscle layers of skin   (MGI Ref ID J:117122)
    • 5 days after flank injection of CpG, mice develop solid subcutaneous swellings at the injection site; lesions show conspicuous edema, massive infiltration by macrophages and neutrophilic granulocytes, and extensive necrosis of the dermis, epidermis and muscle layer of the skin while lesions in controls do not display edema or necrosis and show infiltration by macrophages primarily   (MGI Ref ID J:117122)
    • increased susceptibility to endotoxin shock
      • i.p. injection of LPS results in death in all animal by 48 hours, compared to survival of 23/25 controls   (MGI Ref ID J:117122)
      • LPS-treated mice exhibit uncontrollable release of IL12 and TNF-alpha compared with wild-type mice   (MGI Ref ID J:118833)
    • intestinal inflammation
      • mice show exaggerated inflammatory response upon exposure to CML-mps-containing eluate compared to control   (MGI Ref ID J:113376)
  • increased circulating interleukin-12 level
    • in LPS-treated mice   (MGI Ref ID J:118833)
  • increased circulating tumor necrosis factor level
    • in LPS-treated mice   (MGI Ref ID J:118833)
  • digestive/alimentary phenotype
  • intestinal inflammation
    • mice show exaggerated inflammatory response upon exposure to CML-mps-containing eluate compared to control   (MGI Ref ID J:113376)
  • rectal prolapse
    • 7% of mutants develop rectal prolapse at 16 weeks of age   (MGI Ref ID J:209365)
  • homeostasis/metabolism phenotype
  • increased circulating interleukin-12 level
    • in LPS-treated mice   (MGI Ref ID J:118833)
  • increased circulating tumor necrosis factor level
    • in LPS-treated mice   (MGI Ref ID J:118833)


  • growth/size/body region phenotype
  • slow postnatal weight gain
    • lower body weight gain between 5 and 10 weeks of age than for controls   (MGI Ref ID J:124308)
  • immune system phenotype
  • abnormal cytokine level
    • in LPS-injected mice   (MGI Ref ID J:157787)
    • levels of cytokines increase in the brain are greater than for controls after lipopolysaccharide treatment   (MGI Ref ID J:139972)
    • abnormal chemokine level
      • LPS-injected mice exhibit increased CXCL10 and CXCL1 levels compared with similarly treated wild-type mice   (MGI Ref ID J:157787)
    • increased circulating interferon-gamma level
      • in LPS-injected mice   (MGI Ref ID J:157787)
    • increased circulating interleukin-1 alpha level
      • in LPS-injected mice   (MGI Ref ID J:157787)
    • increased circulating interleukin-1 beta level
      • in LPS-injected mice   (MGI Ref ID J:157787)
      • plasma levels remain elevated for 24 hours after lipopolysaccharide treatment as opposed to 4 hours for controls   (MGI Ref ID J:139972)
    • increased circulating interleukin-12 level
      • in LPS-injected mice   (MGI Ref ID J:157787)
    • increased circulating interleukin-17 level
      • in LPS-injected mice   (MGI Ref ID J:157787)
    • increased circulating interleukin-2 level
      • in LPS-injected mice   (MGI Ref ID J:157787)
    • increased circulating interleukin-6 level
      • slightly in LPS-injected mice   (MGI Ref ID J:157787)
      • plasma levels remain elevated for 24 hours after lipopolysaccharide treatment as opposed to 4 hours for controls   (MGI Ref ID J:139972)
    • increased circulating tumor necrosis factor level
      • in LPS-injected mice   (MGI Ref ID J:157787)
  • abnormal regulatory T cell physiology
    • CD25-positive CD4 T cells from these mice fail to protect against the wasting disease induced by transferring nażve CD4 T cells into immunodeficient hosts   (MGI Ref ID J:125748)
    • however, CD25-postive CD4 T cells inhibit the expansion of naive T cells in Rag2 deficient hosts as effectively as wild-type CD25-positive CD4 T cells   (MGI Ref ID J:125748)
  • increased susceptibility to parasitic infection
    • mice infected with T. muris exhibit increased worm burden and cecum score compared with similarly treated wild-type mice   (MGI Ref ID J:157787)
  • large intestinal inflammation
    • mutants develop severe inflammation in the colon leading to inflammatory bowel disease   (MGI Ref ID J:149347)
    • cecum inflammation
      • mice infected with T. muris exhibit increased worm burden and cecum score compared with similarly treated wild-type mice   (MGI Ref ID J:157787)
    • increased susceptibility to induced colitis
      • upon DSS exposure   (MGI Ref ID J:157787)
  • homeostasis/metabolism phenotype
  • abnormal cytokine level
    • in LPS-injected mice   (MGI Ref ID J:157787)
    • levels of cytokines increase in the brain are greater than for controls after lipopolysaccharide treatment   (MGI Ref ID J:139972)
    • abnormal chemokine level
      • LPS-injected mice exhibit increased CXCL10 and CXCL1 levels compared with similarly treated wild-type mice   (MGI Ref ID J:157787)
    • increased circulating interferon-gamma level
      • in LPS-injected mice   (MGI Ref ID J:157787)
    • increased circulating interleukin-1 alpha level
      • in LPS-injected mice   (MGI Ref ID J:157787)
    • increased circulating interleukin-1 beta level
      • in LPS-injected mice   (MGI Ref ID J:157787)
      • plasma levels remain elevated for 24 hours after lipopolysaccharide treatment as opposed to 4 hours for controls   (MGI Ref ID J:139972)
    • increased circulating interleukin-12 level
      • in LPS-injected mice   (MGI Ref ID J:157787)
    • increased circulating interleukin-17 level
      • in LPS-injected mice   (MGI Ref ID J:157787)
    • increased circulating interleukin-2 level
      • in LPS-injected mice   (MGI Ref ID J:157787)
    • increased circulating interleukin-6 level
      • slightly in LPS-injected mice   (MGI Ref ID J:157787)
      • plasma levels remain elevated for 24 hours after lipopolysaccharide treatment as opposed to 4 hours for controls   (MGI Ref ID J:139972)
    • increased circulating tumor necrosis factor level
      • in LPS-injected mice   (MGI Ref ID J:157787)
  • impaired adaptive thermogenesis
    • lipopolysaccharide causes a very significant drop in core body temperature   (MGI Ref ID J:114404)
  • impaired exercise endurance
    • time to fatigue on a motorized treadmill is reduced 24% after lipopolysaccharide treatment   (MGI Ref ID J:139972)
  • increased cerebral infarction size
    • lesion volume after middle cerebral artery occlusion increases 30%   (MGI Ref ID J:108086)
  • increased susceptibility to neuronal excitotoxicity
    • increased toxicity of N-methyl-D-aspartate in primary neuron culture   (MGI Ref ID J:108086)
  • digestive/alimentary phenotype
  • large intestinal inflammation
    • mutants develop severe inflammation in the colon leading to inflammatory bowel disease   (MGI Ref ID J:149347)
    • cecum inflammation
      • mice infected with T. muris exhibit increased worm burden and cecum score compared with similarly treated wild-type mice   (MGI Ref ID J:157787)
    • increased susceptibility to induced colitis
      • upon DSS exposure   (MGI Ref ID J:157787)
  • rectal prolapse
    • rectal prolapse is seen at a median time of 16 weeks of age   (MGI Ref ID J:149347)
  • cardiovascular system phenotype
  • decreased mean systemic arterial blood pressure
    • lower under basal conditions   (MGI Ref ID J:146372)
  • decreased susceptibility to induced choroidal neovascularization
    • reduced choroidal neovascularization 7 days following krypton laser exposure of the eye   (MGI Ref ID J:134144)
  • decreased vasoconstriction
    • LPS treatment markedly impairs contractions of the carotid artery induced by the thromboxane analogue U46619 and by phenylephrine   (MGI Ref ID J:59742)
  • increased vasoconstriction
    • endothelin 1 induced contraction of Aorta and first order mesenteric arteries is greater than controls when also treated with L-NAME and indomethecine and TNFalpha   (MGI Ref ID J:146372)
    • response to endothelin 1 is eliminated in the presence of PD-98059   (MGI Ref ID J:146372)
  • muscle phenotype
  • decreased vasoconstriction
    • LPS treatment markedly impairs contractions of the carotid artery induced by the thromboxane analogue U46619 and by phenylephrine   (MGI Ref ID J:59742)
  • increased vasoconstriction
    • endothelin 1 induced contraction of Aorta and first order mesenteric arteries is greater than controls when also treated with L-NAME and indomethecine and TNFalpha   (MGI Ref ID J:146372)
    • response to endothelin 1 is eliminated in the presence of PD-98059   (MGI Ref ID J:146372)
  • behavior/neurological phenotype
  • abnormal sleep pattern
    • more time in "slow-wave sleep" and less time awake during dark phase   (MGI Ref ID J:114404)
    • less effect of influenza virus infection on slow wave sleep during dark phase but a greater decrease in delta wave amplitude   (MGI Ref ID J:114404)
    • lipopolysaccharide causes an overall decrease in delta wave amplitude   (MGI Ref ID J:114404)
    • lipopolysaccharide causes decreased slow wave and REM sleep during light phase   (MGI Ref ID J:114404)
    • lipopolysaccharide results in increased time spent awake, particularly in light phase   (MGI Ref ID J:114404)
  • impaired coordination
    • rotarod performance worsens after IP lipopolysaccharide injection   (MGI Ref ID J:139972)
    • effect persists at least 24 hours   (MGI Ref ID J:139972)
    • performance fails to improve over consecutive trials but only after IP lipopolysaccharide injection   (MGI Ref ID J:139972)
  • impaired exercise endurance
    • time to fatigue on a motorized treadmill is reduced 24% after lipopolysaccharide treatment   (MGI Ref ID J:139972)
  • nervous system phenotype
  • abnormal neuron physiology
    • increased sensitivity to oxygen or glucose deprivation   (MGI Ref ID J:108086)
    • increased susceptibility to neuronal excitotoxicity
      • increased toxicity of N-methyl-D-aspartate in primary neuron culture   (MGI Ref ID J:108086)
  • increased cerebral infarction size
    • lesion volume after middle cerebral artery occlusion increases 30%   (MGI Ref ID J:108086)
  • vision/eye phenotype
  • decreased susceptibility to induced choroidal neovascularization
    • reduced choroidal neovascularization 7 days following krypton laser exposure of the eye   (MGI Ref ID J:134144)
  • tumorigenesis
  • increased colon adenocarcinoma incidence
    • 20% of mutants with colonic inflammation exhibit colon tumors; tumors are adenocarcinomas   (MGI Ref ID J:149347)
    • tumors develop between 25 and 35 weeks of age   (MGI Ref ID J:149347)
  • cellular phenotype
  • increased susceptibility to neuronal excitotoxicity
    • increased toxicity of N-methyl-D-aspartate in primary neuron culture   (MGI Ref ID J:108086)
  • hematopoietic system phenotype
  • abnormal regulatory T cell physiology
    • CD25-positive CD4 T cells from these mice fail to protect against the wasting disease induced by transferring nażve CD4 T cells into immunodeficient hosts   (MGI Ref ID J:125748)
    • however, CD25-postive CD4 T cells inhibit the expansion of naive T cells in Rag2 deficient hosts as effectively as wild-type CD25-positive CD4 T cells   (MGI Ref ID J:125748)


        involves: 129P2/OlaHsd * C57BL/6 * DBA/1
  • growth/size/body region phenotype
  • decreased body weight
    • lower body weight than controls   (MGI Ref ID J:84100)
  • digestive/alimentary phenotype
  • colitis
    • increased lymphocytes in the lamina propria   (MGI Ref ID J:84100)
    • inflamatory cells in the mucosa   (MGI Ref ID J:84100)
    • epithelial hyperplasia   (MGI Ref ID J:84100)
    • reduced mucin producing goblet cells   (MGI Ref ID J:84100)
  • immune system phenotype
  • colitis
    • increased lymphocytes in the lamina propria   (MGI Ref ID J:84100)
    • inflamatory cells in the mucosa   (MGI Ref ID J:84100)
    • epithelial hyperplasia   (MGI Ref ID J:84100)
    • reduced mucin producing goblet cells   (MGI Ref ID J:84100)


        involves: 129P2/OlaHsd * 129S/SvEv
  • growth/size/body region phenotype
  • decreased body weight
    • mice older than 4 weeks weigh significantly less than controls   (MGI Ref ID J:59872)
  • digestive/alimentary phenotype
  • abnormal intestine physiology
    • increased colon permeability to mannitol at 2, 4, and 10weeks but not under germ free conditions   (MGI Ref ID J:59872)
    • ileal permeability to mannitol 3X higher than in controls at 2 weeks but normal at 6 weeks   (MGI Ref ID J:59872)
    • more IFNgamma and TNFalpha produced in the ileum and colon than in controls   (MGI Ref ID J:59872)
    • colonic iNOS production increases with age after 4 weeks   (MGI Ref ID J:59872)
    • colitis
      • mild colitis at 4 weeks which plateaus by 8 weeks   (MGI Ref ID J:59872)
      • no ileal injury through 16 weeks   (MGI Ref ID J:59872)
      • no colitis when raised in germ free conditions   (MGI Ref ID J:59872)
  • immune system phenotype
  • colitis
    • mild colitis at 4 weeks which plateaus by 8 weeks   (MGI Ref ID J:59872)
    • no ileal injury through 16 weeks   (MGI Ref ID J:59872)
    • no colitis when raised in germ free conditions   (MGI Ref ID J:59872)


  • cardiovascular system phenotype
  • decreased vasoconstriction
    • LPS treatment markedly impairs contractions of the carotid artery induced by the thromboxane analogue U46619 and by phenylephrine   (MGI Ref ID J:59742)
  • muscle phenotype
  • decreased vasoconstriction
    • LPS treatment markedly impairs contractions of the carotid artery induced by the thromboxane analogue U46619 and by phenylephrine   (MGI Ref ID J:59742)


  • immune system phenotype
  • decreased length of allograft survival
    • decrease in survival times of heart transplants from BALB/c mice after a 30 day course of anti-CD4 and anti-CD8 mAb   (MGI Ref ID J:44346)
    • acute rejection severity of cardiac allografts (BALB/c) is increased compared to wild-type controls   (MGI Ref ID J:44346)


  • immune system phenotype
  • abnormal circulating interleukin-12b level
    • PGE2 represses LPS induction to a lesser extent than it does in controls   (MGI Ref ID J:191723)
  • abnormal circulating interleukin-6 level
    • PGE2 represses LPS induction to a lesser extent than it does in controls   (MGI Ref ID J:191723)
  • homeostasis/metabolism phenotype
  • abnormal circulating interleukin-12b level
    • PGE2 represses LPS induction to a lesser extent than it does in controls   (MGI Ref ID J:191723)
  • abnormal circulating interleukin-6 level
    • PGE2 represses LPS induction to a lesser extent than it does in controls   (MGI Ref ID J:191723)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Cell Biology Research
Signal Transduction
Transcriptional Regulation

Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
      Tlr deficiency
Growth Factors/Receptors/Cytokines
      Inflammatory bowel disease
      Tlr deficiency
      defects in humoral immune responses
      multiple immune defects
Immunodeficiency Associated with Other Defects
      Inflammatory bowel disease
      Tlr deficiency
Intracellular Signaling Molecules

Internal/Organ Research
Gastrointestinal Defects

Research Tools
Cell Biology Research
Immunology, Inflammation and Autoimmunity Research

Il10tm1Cgn related

Cancer Research
Growth Factors/Receptors/Cytokines

Hematological Research
Anemia, Iron Deficiency and Transport Defects
Immunological Defects

Immunology, Inflammation and Autoimmunity Research
Growth Factors/Receptors/Cytokines
      Inflammatory bowel disease

Pde6brd1 related

Sensorineural Research
Retinal Degeneration

Tlr4Lps-d related

Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
      Tlr deficiency
      Tlr deficiency
      Tlr deficiency

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol Il10tm1Cgn
Allele Name targeted mutation 1, University of Cologne
Allele Type Targeted (Null/Knockout)
Common Name(s) IL-10 KO; IL-10-; IL-10KO; IL-10KO; Il10-; Il10tmCgn;
Mutation Made ByDr. Ralf Kuhn,   University of Cologne
Strain of Origin129P2/OlaHsd
ES Cell Line NameE14.1
ES Cell Line Strain129P2/OlaHsd
Gene Symbol and Name Il10, interleukin 10
Chromosome 1
Gene Common Name(s) CSIF; GVHDS; IL-10; IL10A; IL10X; Il-10; TGIF; cytokine synthesis inhibitory factor;
General Note Phenotypic Similarity to Human Syndrome: Idiopathic Inflammatory Bowel Disease (J:15222).
Molecular Note A 500 bp genomic fragment containing codons 5-55 was replaced with a linker containing a termination codon followed by a neomycin cassette. A termination codon was also introduced into exon 3. No IL10 activity was detectable by ELISA assays in supernatants of in vitro cultures of Con A-stimulated splenic T cells derived from homozygous mice following infection with the nematode N. brasiliensis. [MGI Ref ID J:15222]
Allele Symbol Pde6brd1
Allele Name retinal degeneration 1
Allele Type Spontaneous
Common Name(s) Pdebrd1; rd; rd-1; rd1; rodless retina;
Strain of Originvarious
Gene Symbol and Name Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
Chromosome 5
Gene Common Name(s) CSNB3; CSNBAD2; PDEB; Pdeb; RP40; nmf137; phosphodiesterase, cGMP, rod receptor, beta polypeptide; r; rd; rd-1; rd1; rd10; retinal degeneration; retinal degeneration 1; retinal degeneration 10;
General Note The following inbred strains are known to be homozygous for Pde6b: C3H sublines, CBA/J, FVB/NJ, PL/J, SB, SJL/J, and SWR/J.
Molecular Note Two mutations have been identified in rd1 mice. A murine leukimia virus (Xmv-28) insertion in reverse orientation in intron 1 is found in all mouse strains with the rd1 phenotype. Further, a nonsense mutation (C to A transversion) in codon 347 that results in a truncation eliminating more than half of the predicted encoded protein, including the catalytic domain has also been identified in all rd1 strains of mice. A specific degradation of mutant transcript during or after pre-mRNA splicing is suggested. [MGI Ref ID J:11513] [MGI Ref ID J:4366] [MGI Ref ID J:51361]
Allele Symbol Tlr4Lps-d
Allele Name defective lipopolysaccharide response
Allele Type Spontaneous
Common Name(s) TLR4-M; TLR4-Mu; TLR4lps-def; TLR4d; Tlr4-; Tlr4d; TlrLps-d; lpsd; mutant TLR4;
Strain of OriginC3H/HeJ
Gene Symbol and Name Tlr4, toll-like receptor 4
Chromosome 4
Gene Common Name(s) ARMD10; CD284; Lps; RAS-like, family 2, locus 8; Rasl2-8; TLR-4; TOLL; lipopolysaccharide response;
General Note C3H/HeJ mice carry this allele. Various combinations of Lps-associated traits have been followed in crosses between C3H/HeJ and other C3H substrains, and the traits have in all cases segregated together (J:30692, J:5557, J:5593, J:5938). Some of the traits show dominance of the Tlr4lps-n allele; others, including Tlr4Lps-d, show codominance.

Genbank ID for this allele: AF095353

Molecular Note This allele corresponds to a mutation in the third exon of the gene. A C to A substitution at nucleotide position 2342 results in an amino acid substitution that replaces proline with histidine at position 712. [MGI Ref ID J:51522] [MGI Ref ID J:53519] [MGI Ref ID J:57938]


Genotyping Information

Genotyping Protocols

Il10tm1Cgn, High Resolution Melting
Il10tm1Cgn, Standard PCR

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Additional References

Il10tm1Cgn related

Aggarwal NR; Tsushima K; Eto Y; Tripathi A; Mandke P; Mock JR; Garibaldi BT; Singer BD; Sidhaye VK; Horton MR; King LS; D'Alessio FR. 2014. Immunological priming requires regulatory T cells and IL-10-producing macrophages to accelerate resolution from severe lung inflammation. J Immunol 192(9):4453-64. [PubMed: 24688024]  [MGI Ref ID J:209966]

Akhiani AA; Stensson A; Schon K; Lycke NY. 2005. IgA antibodies impair resistance against Helicobacter pylori infection: studies on immune evasion in IL-10-deficient mice. J Immunol 174(12):8144-53. [PubMed: 15944323]  [MGI Ref ID J:100891]

Alayan J; Ivanovski S; Farah CS. 2007. Alveolar bone loss in T helper 1/T helper 2 cytokine-deficient mice. J Periodontal Res 42(2):97-103. [PubMed: 17305866]  [MGI Ref ID J:147935]

Albert E; Walker J; Thiesen A; Churchill T; Madsen K. 2010. cis-Urocanic acid attenuates acute dextran sodium sulphate-induced intestinal inflammation. PLoS One 5(10):e13676. [PubMed: 21060867]  [MGI Ref ID J:166665]

Aliberti J; Viola JP; Vieira-de-Abreu A; Bozza PT; Sher A; Scharfstein J. 2003. Cutting edge: Bradykinin induces IL-12 production by dendritic cells: a danger signal that drives Th1 polarization. J Immunol 170(11):5349-53. [PubMed: 12759407]  [MGI Ref ID J:83453]

Allen HL; Deepe GS Jr. 2005. Apoptosis modulates protective immunity to the pathogenic fungus Histoplasma capsulatum. J Clin Invest 115(10):2875-85. [PubMed: 16151533]  [MGI Ref ID J:101533]

Allen HL; Deepe GS Jr. 2006. B cells and CD4-CD8- T cells are key regulators of the severity of reactivation histoplasmosis. J Immunol 177(3):1763-71. [PubMed: 16849486]  [MGI Ref ID J:138028]

Almeida AR; Legrand N; Papiernik M; Freitas AA. 2002. Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers. J Immunol 169(9):4850-60. [PubMed: 12391195]  [MGI Ref ID J:125748]

Amante FH; Stanley AC; Randall LM; Zhou Y; Haque A; McSweeney K; Waters AP; Janse CJ; Good MF; Hill GR; Engwerda CR. 2007. A role for natural regulatory T cells in the pathogenesis of experimental cerebral malaria. Am J Pathol 171(2):548-59. [PubMed: 17600128]  [MGI Ref ID J:123927]

Ameredes BT; Sethi JM; Liu HL; Choi AM; Calhoun WJ. 2005. Enhanced nitric oxide production associated with airway hyporesponsiveness in the absence of IL-10. Am J Physiol Lung Cell Mol Physiol 288(5):L868-73. [PubMed: 15618456]  [MGI Ref ID J:115459]

Ameredes BT; Zamora R; Gibson KF; Billiar TR; Dixon-McCarthy B; Watkins S; Calhoun WJ. 2001. Increased nitric oxide production by airway cells of sensitized and challenged IL-10 knockout mice. J Leukoc Biol 70(5):730-6. [PubMed: 11698492]  [MGI Ref ID J:124461]

Ameredes BT; Zamora R; Sethi JM; Liu HL; Kohut LK; Gligonic AL; Choi AM; Calhoun WJ. 2005. Alterations in nitric oxide and cytokine production with airway inflammation in the absence of IL-10. J Immunol 175(2):1206-13. [PubMed: 16002724]  [MGI Ref ID J:100726]

Ananieva O; Darragh J; Johansen C; Carr JM; McIlrath J; Park JM; Wingate A; Monk CE; Toth R; Santos SG; Iversen L; Arthur JS. 2008. The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling. Nat Immunol 9(9):1028-36. [PubMed: 18690222]  [MGI Ref ID J:139576]

Anderson AC; Reddy J; Nazareno R; Sobel RA; Nicholson LB; Kuchroo VK. 2004. IL-10 plays an important role in the homeostatic regulation of the autoreactive repertoire in naive mice. J Immunol 173(2):828-34. [PubMed: 15240669]  [MGI Ref ID J:91913]

Anderson CF; Oukka M; Kuchroo VJ; Sacks D. 2007. CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis. J Exp Med 204(2):285-97. [PubMed: 17283207]  [MGI Ref ID J:125372]

Andou A; Hisamatsu T; Okamoto S; Chinen H; Kamada N; Kobayashi T; Hashimoto M; Okutsu T; Shimbo K; Takeda T; Matsumoto H; Sato A; Ohtsu H; Suzuki M; Hibi T. 2009. Dietary histidine ameliorates murine colitis by inhibition of proinflammatory cytokine production from macrophages. Gastroenterology 136(2):564-74.e2. [PubMed: 19027739]  [MGI Ref ID J:145874]

Andrade EB; Alves J; Madureira P; Oliveira L; Ribeiro A; Cordeiro-da-Silva A; Correia-Neves M; Trieu-Cuot P; Ferreira P. 2013. TLR2-induced IL-10 production impairs neutrophil recruitment to infected tissues during neonatal bacterial sepsis. J Immunol 191(9):4759-68. [PubMed: 24078699]  [MGI Ref ID J:206234]

Andrassy M; Igwe J; Autschbach F; Volz C; Remppis A; Neurath MF; Schleicher E; Humpert PM; Wendt T; Liliensiek B; Morcos M; Schiekofer S; Thiele K; Chen J; Kientsch-Engel R; Schmidt AM; Stremmel W; Stern DM; Katus HA; Nawroth PP; Bierhaus A. 2006. Posttranslationally modified proteins as mediators of sustained intestinal inflammation. Am J Pathol 169(4):1223-37. [PubMed: 17003481]  [MGI Ref ID J:113376]

Ankathatti Munegowda M; Xu S; Freywald A; Xiang J. 2012. CD4+ Th2 cells function alike effector Tr1 and Th1 cells through the deletion of a single cytokine IL-6 and IL-10 gene. Mol Immunol 51(2):143-9. [PubMed: 22424785]  [MGI Ref ID J:184874]

Apte RS; Richter J; Herndon J; Ferguson TA. 2006. Macrophages inhibit neovascularization in a murine model of age-related macular degeneration. PLoS Med 3(8):e310. [PubMed: 16903779]  [MGI Ref ID J:134144]

Arrieta MC; Madsen K; Doyle J; Meddings J. 2009. Reducing small intestinal permeability attenuates colitis in the IL10 gene-deficient mouse. Gut 58(1):41-8. [PubMed: 18829978]  [MGI Ref ID J:213262]

Arsenescu R; Blum AM; Metwali A; Elliott DE; Weinstock JV. 2005. IL-12 induction of mRNA encoding substance P in murine macrophages from the spleen and sites of inflammation. J Immunol 174(7):3906-11. [PubMed: 15778345]  [MGI Ref ID J:110005]

Auerbuch V; Isberg RR. 2007. Growth of Yersinia pseudotuberculosis in Mice Occurs Independently of Toll-Like Receptor 2 Expression and Induction of Interleukin-10. Infect Immun 75(7):3561-70. [PubMed: 17420232]  [MGI Ref ID J:122417]

Aviszus K; Macleod MK; Kirchenbaum GA; Detanico TO; Heiser RA; St Clair JB; Guo W; Wysocki LJ. 2012. Antigen-specific suppression of humoral immunity by anergic Ars/A1 B cells. J Immunol 189(9):4275-83. [PubMed: 23008448]  [MGI Ref ID J:190617]

Awasthi A; Carrier Y; Peron JP; Bettelli E; Kamanaka M; Flavell RA; Kuchroo VK; Oukka M; Weiner HL. 2007. A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. Nat Immunol 8(12):1380-9. [PubMed: 17994022]  [MGI Ref ID J:127774]

Bai F; Town T; Qian F; Wang P; Kamanaka M; Connolly TM; Gate D; Montgomery RR; Flavell RA; Fikrig E. 2009. IL-10 signaling blockade controls murine West Nile virus infection. PLoS Pathog 5(10):e1000610. [PubMed: 19816558]  [MGI Ref ID J:162907]

Balasa B; La Cava A; Van Gunst K; Mocnik L; Balakrishna D; Nguyen N; Tucker L; Sarvetnick N. 2000. A mechanism for IL-10-mediated diabetes in the nonobese diabetic (NOD) mouse: ICAM-1 deficiency blocks accelerated diabetes J Immunol 165(12):7330-7. [PubMed: 11120869]  [MGI Ref ID J:66103]

Balasa B; Van Gunst K; Jung N; Katz JD; Sarvetnick N. 2000. IL-10 deficiency does not inhibit insulitis and accelerates cyclophosphamide-induced diabetes in the nonobese diabetic mouse. Cell Immunol 202(2):97-102. [PubMed: 10896769]  [MGI Ref ID J:114170]

Bamboat ZM; Ocuin LM; Balachandran VP; Obaid H; Plitas G; Dematteo RP. 2010. Conventional DCs reduce liver ischemia/reperfusion injury in mice via IL-10 secretion. J Clin Invest 120(2):559-69. [PubMed: 20093775]  [MGI Ref ID J:156672]

Bandukwala HS; Clay BS; Tong J; Mody PD; Cannon JL; Shilling RA; Verbeek JS; Weinstock JV; Solway J; Sperling AI. 2007. Signaling through Fc gamma RIII is required for optimal T helper type (Th)2 responses and Th2-mediated airway inflammation. J Exp Med 204(8):1875-89. [PubMed: 17664287]  [MGI Ref ID J:125951]

Barbi J; Brombacher F; Satoskar AR. 2008. T Cells from Leishmania major-susceptible BALB/c mice have a defect in efficiently up-regulating CXCR3 upon activation. J Immunol 181(7):4613-20. [PubMed: 18802063]  [MGI Ref ID J:141294]

Bassaganya-Riera J; Viladomiu M; Pedragosa M; De Simone C; Hontecillas R. 2012. Immunoregulatory mechanisms underlying prevention of colitis-associated colorectal cancer by probiotic bacteria. PLoS One 7(4):e34676. [PubMed: 22511958]  [MGI Ref ID J:187088]

Beatty PL; Plevy SE; Sepulveda AR; Finn OJ. 2007. Cutting edge: transgenic expression of human MUC1 in IL-10-/- mice accelerates inflammatory bowel disease and progression to colon cancer. J Immunol 179(2):735-9. [PubMed: 17617560]  [MGI Ref ID J:149347]

Beckwith J; Cong Y; Sundberg JP; Elson CO; Leiter EH. 2005. Cdcs1, a major colitogenic locus in mice, regulates innate and adaptive immune response to enteric bacterial antigens. Gastroenterology 129(5):1473-84. [PubMed: 16285949]  [MGI Ref ID J:101721]

Beenhouwer DO; Shapiro S; Feldmesser M; Casadevall A; Scharff MD. 2001. Both Th1 and Th2 Cytokines Affect the Ability of Monoclonal Antibodies To Protect Mice against Cryptococcus neoformans. Infect Immun 69(10):6445-55. [PubMed: 11553589]  [MGI Ref ID J:71570]

Beissert S; Hosoi J; Kuhn R; Rajewsky K; Muller W; Granstein RD. 1996. Impaired immunosuppressive response to ultraviolet radiation in interleukin-10-deficient mice. J Invest Dermatol 107(4):553-7. [PubMed: 8823360]  [MGI Ref ID J:35510]

Beiting DP; Bliss SK; Schlafer DH; Roberts VL; Appleton JA. 2004. Interleukin-10 limits local and body cavity inflammation during infection with muscle-stage Trichinella spiralis. Infect Immun 72(6):3129-37. [PubMed: 15155614]  [MGI Ref ID J:90250]

Belkaid Y; Hoffmann KF; Mendez S; Kamhawi S; Udey MC; Wynn TA; Sacks DL. 2001. The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure. J Exp Med 194(10):1497-506. [PubMed: 11714756]  [MGI Ref ID J:118003]

Berg DJ; Davidson N; Kuhn R; Muller W; Menon S; Holland G; Thompson-Snipes L; Leach MW; Rennick D. 1996. Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses. J Clin Invest 98(4):1010-20. [PubMed: 8770874]  [MGI Ref ID J:35020]

Berg DJ; Leach MW; Kuhn R; Rajewsky K; Muller W; Davidson NJ; Rennick D. 1995. Interleukin 10 but not interleukin 4 is a natural suppressant of cutaneous inflammatory responses. J Exp Med 182(1):99-108. [PubMed: 7790826]  [MGI Ref ID J:26221]

Bernert H; Sekikawa K; Radcliffe RA; Iraqi F; You M; Malkinson AM. 2003. Tnfa and Il-10 deficiencies have contrasting effects on lung tumor susceptibility: Gender-dependent modulation of IL-10 haploinsufficiency. Mol Carcinog 38(3):117-23. [PubMed: 14587096]  [MGI Ref ID J:86489]

Bettelli E; Das MP; Howard ED; Weiner HL; Sobel RA; Kuchroo VK. 1998. IL-10 is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10- and IL-4-deficient and transgenic mice. J Immunol 161(7):3299-306. [PubMed: 9759845]  [MGI Ref ID J:115204]

Bettenworth D; Buyse M; Bohm M; Mennigen R; Czorniak I; Kannengiesser K; Brzoska T; Luger TA; Kucharzik T; Domschke W; Maaser C; Lugering A. 2011. The tripeptide KdPT protects from intestinal inflammation and maintains intestinal barrier function. Am J Pathol 179(3):1230-42. [PubMed: 21741932]  [MGI Ref ID J:176323]

Bhattacharyya S; Deb J; Patra AK; Thuy Pham DA; Chen W; Vaeth M; Berberich-Siebelt F; Klein-Hessling S; Lamperti ED; Reifenberg K; Jellusova J; Schweizer A; Nitschke L; Leich E; Rosenwald A; Brunner C; Engelmann S; Bommhardt U; Avots A; Muller MR; Kondo E; Serfling E. 2011. NFATc1 affects mouse splenic B cell function by controlling the calcineurin--NFAT signaling network. J Exp Med 208(4):823-39. [PubMed: 21464221]  [MGI Ref ID J:177319]

Biburger M; Tiegs G. 2008. Activation-induced NKT cell hyporesponsiveness protects from alpha-galactosylceramide hepatitis and is independent of active transregulatory factors. J Leukoc Biol 84(1):264-79. [PubMed: 18407967]  [MGI Ref ID J:137749]

Biswas A; Wilmanski J; Forsman H; Hrncir T; Hao L; Tlaskalova-Hogenova H; Kobayashi KS. 2011. Negative regulation of Toll-like receptor signaling plays an essential role in homeostasis of the intestine. Eur J Immunol 41(1):182-94. [PubMed: 21182089]  [MGI Ref ID J:174655]

Bleich A; Buchler G; Beckwith J; Petell LM; Affourtit JP; King BL; Shaffer DJ; Roopenian DC; Hedrich HJ; Sundberg JP; Leiter EH. 2010. Cdcs1 a major colitis susceptibility locus in mice; subcongenic analysis reveals genetic complexity. Inflamm Bowel Dis 16(5):765-75. [PubMed: 19856416]  [MGI Ref ID J:171733]

Bleich A; Janus LM; Smoczek A; Westendorf AM; Strauch U; Mahler M; Hedrich HJ; Fichtner-Feigl S; Scholmerich J; Falk W; Hofmann C; Obermeier F. 2009. CpG motifs of bacterial DNA exert protective effects in mouse models of IBD by antigen-independent tolerance induction. Gastroenterology 136(1):278-87. [PubMed: 18952084]  [MGI Ref ID J:145618]

Bliss SK; Alcaraz A; Appleton JA. 2003. IL-10 prevents liver necrosis during murine infection with Trichinella spiralis. J Immunol 171(6):3142-7. [PubMed: 12960341]  [MGI Ref ID J:85372]

Bliss SK; Bliss SP; Beiting DP; Alcaraz A; Appleton JA. 2007. IL-10 regulates movement of intestinally derived CD4+ T cells to the liver. J Immunol 178(12):7974-83. [PubMed: 17548634]  [MGI Ref ID J:148582]

Blois SM; Ilarregui JM; Tometten M; Garcia M; Orsal AS; Cordo-Russo R; Toscano MA; Bianco GA; Kobelt P; Handjiski B; Tirado I; Markert UR; Klapp BF; Poirier F; Szekeres-Bartho J; Rabinovich GA; Arck PC. 2007. A pivotal role for galectin-1 in fetomaternal tolerance. Nat Med 13(12):1450-7. [PubMed: 18026113]  [MGI Ref ID J:130208]

Blum A; Setiawan T; Hang L; Stoyanoff K; Weinstock JV. 2008. Interleukin-12 (IL-12) and IL-23 induction of substance p synthesis in murine T cells and macrophages is subject to IL-10 and transforming growth factor beta regulation. Infect Immun 76(8):3651-6. [PubMed: 18505813]  [MGI Ref ID J:139373]

Bollyky PL; Falk BA; Long SA; Preisinger A; Braun KR; Wu RP; Evanko SP; Buckner JH; Wight TN; Nepom GT. 2009. CD44 costimulation promotes FoxP3+ regulatory T cell persistence and function via production of IL-2, IL-10, and TGF-beta. J Immunol 183(4):2232-41. [PubMed: 19635906]  [MGI Ref ID J:151479]

Bollyky PL; Wu RP; Falk BA; Lord JD; Long SA; Preisinger A; Teng B; Holt GE; Standifer NE; Braun KR; Xie CF; Samuels PL; Vernon RB; Gebe JA; Wight TN; Nepom GT. 2011. ECM components guide IL-10 producing regulatory T-cell (TR1) induction from effector memory T-cell precursors. Proc Natl Acad Sci U S A 108(19):7938-43. [PubMed: 21518860]  [MGI Ref ID J:172198]

Bosmann M; Haggadone MD; Zetoune FS; Sarma JV; Ward PA. 2013. The interaction between C5a and both C5aR and C5L2 receptors is required for production of G-CSF during acute inflammation. Eur J Immunol 43(7):1907-13. [PubMed: 23575697]  [MGI Ref ID J:201024]

Bosschaerts T; Guilliams M; Noel W; Herin M; Burk RF; Hill KE; Brys L; Raes G; Ghassabeh GH; De Baetselier P; Beschin A. 2008. Alternatively activated myeloid cells limit pathogenicity associated with African trypanosomiasis through the IL-10 inducible gene selenoprotein P. J Immunol 180(9):6168-75. [PubMed: 18424738]  [MGI Ref ID J:134536]

Bowie RV; Donatello S; Lyes C; Owens MB; Babina IS; Hudson L; Walsh SV; O'Donoghue DP; Amu S; Barry SP; Fallon PG; Hopkins AM. 2012. Lipid rafts are disrupted in mildly inflamed intestinal microenvironments without overt disruption of the epithelial barrier. Am J Physiol Gastrointest Liver Physiol 302(8):G781-93. [PubMed: 22241861]  [MGI Ref ID J:185388]

Brewer S; McPherson M; Fujiwara D; Turovskaya O; Ziring D; Chen L; Takedatsu H; Targan SR; Wei B; Braun J. 2008. Molecular imaging of murine intestinal inflammation with 2-deoxy-2-[18F]fluoro-D-glucose and positron emission tomography. Gastroenterology 135(3):744-55. [PubMed: 18639553]  [MGI Ref ID J:142005]

Bristol IJ; Farmer MA; Cong Y; Zheng XX; Strom TB; Elson CO; Sundberg JP; Leiter EH. 2000. Heritable susceptibility for colitis in mice induced by IL-10 deficiency. Inflamm Bowel Dis 6(4):290-302. [PubMed: 11149562]  [MGI Ref ID J:109882]

Brooks DG; Trifilo MJ; Edelmann KH; Teyton L; McGavern DB; Oldstone MB. 2006. Interleukin-10 determines viral clearance or persistence in vivo. Nat Med 12(11):1301-9. [PubMed: 17041596]  [MGI Ref ID J:115332]

Brooks DG; Walsh KB; Elsaesser H; Oldstone MB. 2010. IL-10 directly suppresses CD4 but not CD8 T cell effector and memory responses following acute viral infection. Proc Natl Acad Sci U S A 107(7):3018-23. [PubMed: 20133700]  [MGI Ref ID J:157557]

Browne EP. 2013. Toll-Like Receptor 7 Inhibits Early Acute Retroviral Infection through Rapid Lymphocyte Responses. J Virol 87(13):7357-66. [PubMed: 23616654]  [MGI Ref ID J:198442]

Brunn A; Mihelcic M; Carstov M; Hummel L; Geier F; Schmidt A; Saupe L; Utermohlen O; Deckert M. 2014. IL-10, IL-4, and STAT6 promote an M2 milieu required for termination of P0(106-125)-induced murine experimental autoimmune neuritis. Am J Pathol 184(10):2627-40. [PubMed: 25108223]  [MGI Ref ID J:214835]

Bundoc VG; Keane-Myers A. 2007. IL-10 confers protection from mast cell degranulation in a mouse model of allergic conjunctivitis. Exp Eye Res 85(4):575-9. [PubMed: 17765892]  [MGI Ref ID J:126367]

Bunt SK; Clements VK; Hanson EM; Sinha P; Ostrand-Rosenberg S. 2009. Inflammation enhances myeloid-derived suppressor cell cross-talk by signaling through Toll-like receptor 4. J Leukoc Biol 85(6):996-1004. [PubMed: 19261929]  [MGI Ref ID J:149766]

Burich A; Hershberg R; Waggie K; Zeng W; Brabb T; Westrich G; Viney JL; Maggio-Price L. 2001. Helicobacter-induced inflammatory bowel disease in IL-10- and T cell-deficient mice. Am J Physiol Gastrointest Liver Physiol 281(3):G764-78. [PubMed: 11518689]  [MGI Ref ID J:108283]

Buxbaum LU; Scott P. 2005. Interleukin 10- and Fcgamma receptor-deficient mice resolve Leishmania mexicana lesions. Infect Immun 73(4):2101-8. [PubMed: 15784551]  [MGI Ref ID J:97206]

Cain JA; Smith JA; Ondr JK; Wang B; Katz JD. 2006. NKT cells and IFN-gamma establish the regulatory environment for the control of diabetogenic T cells in the nonobese diabetic mouse. J Immunol 176(3):1645-54. [PubMed: 16424194]  [MGI Ref ID J:126603]

Caligiuri G; Rudling M; Ollivier V; Jacob MP; Michel JB; Hansson GK; Nicoletti A. 2003. Interleukin-10 deficiency increases atherosclerosis, thrombosis, and low-density lipoproteins in apolipoprotein E knockout mice. Mol Med 9(1-2):10-7. [PubMed: 12765335]  [MGI Ref ID J:105858]

Cantorna MT; Munsick C; Bemiss C; Mahon BD. 2000. 1,25-Dihydroxycholecalciferol prevents and ameliorates symptoms of experimental murine inflammatory bowel disease J Nutr 130(11):2648-52. [PubMed: 11053501]  [MGI Ref ID J:65513]

Cao AT; Yao S; Stefka AT; Liu Z; Qin H; Liu H; Evans-Marin HL; Elson CO; Nagler CR; Cong Y. 2014. TLR4 regulates IFN-gamma and IL-17 production by both thymic and induced Foxp3+ Tregs during intestinal inflammation. J Leukoc Biol 96(5):895-905. [PubMed: 25015957]  [MGI Ref ID J:220139]

Carregaro V; Valenzuela JG; Cunha TM; Verri WA Jr; Grespan R; Matsumura G; Ribeiro JM; Elnaiem DE; Silva JS; Cunha FQ. 2008. Phlebotomine salivas inhibit immune inflammation-induced neutrophil migration via an autocrine DC-derived PGE2/IL-10 sequential pathway. J Leukoc Biol 84(1):104-14. [PubMed: 18390928]  [MGI Ref ID J:137750]

Carrero JA; Calderon B; Unanue ER. 2006. Lymphocytes are detrimental during the early innate immune response against Listeria monocytogenes. J Exp Med 203(4):933-40. [PubMed: 16549598]  [MGI Ref ID J:123753]

Carroll IM; Andrus JM; Bruno-Barcena JM; Klaenhammer TR; Hassan HM; Threadgill DS. 2007. Anti-inflammatory properties of Lactobacillus gasseri expressing manganese superoxide dismutase using the interleukin 10-deficient mouse model of colitis. Am J Physiol Gastrointest Liver Physiol 293(4):G729-38. [PubMed: 17640978]  [MGI Ref ID J:126666]

Cascio JA; Haymaker CL; Divekar RD; Zaghouani S; Khairallah MT; Wan X; Rowland LM; Dhakal M; Chen W; Zaghouani H. 2013. Antigen-specific effector CD4 T lymphocytes school lamina propria dendritic cells to transfer innate tolerance. J Immunol 190(12):6004-14. [PubMed: 23686493]  [MGI Ref ID J:204839]

Cassani B; Villablanca EJ; Quintana FJ; Love PE; Lacy-Hulbert A; Blaner WS; Sparwasser T; Snapper SB; Weiner HL; Mora JR. 2011. Gut-tropic T cells that express integrin alpha4beta7 and CCR9 are required for induction of oral immune tolerance in mice. Gastroenterology 141(6):2109-18. [PubMed: 21925467]  [MGI Ref ID J:180414]

Castano AP; Lin SL; Surowy T; Nowlin BT; Turlapati SA; Patel T; Singh A; Li S; Lupher ML Jr; Duffield JS. 2009. Serum amyloid P inhibits fibrosis through Fc gamma R-dependent monocyte-macrophage regulation in vivo. Sci Transl Med 1(5):5ra13. [PubMed: 20368175]  [MGI Ref ID J:167887]

Cedeno-Laurent F; Opperman M; Barthel SR; Kuchroo VK; Dimitroff CJ. 2012. Galectin-1 triggers an immunoregulatory signature in Th cells functionally defined by IL-10 expression. J Immunol 188(7):3127-37. [PubMed: 22345665]  [MGI Ref ID J:183114]

Chacon-Salinas R; Limon-Flores AY; Chavez-Blanco AD; Gonzalez-Estrada A; Ullrich SE. 2011. Mast cell-derived IL-10 suppresses germinal center formation by affecting T follicular helper cell function. J Immunol 186(1):25-31. [PubMed: 21098222]  [MGI Ref ID J:168010]

Chang EY; Guo B; Doyle SE; Cheng G. 2007. Cutting edge: involvement of the type I IFN production and signaling pathway in lipopolysaccharide-induced IL-10 production. J Immunol 178(11):6705-9. [PubMed: 17513714]  [MGI Ref ID J:147854]

Chang J; Kunkel SL; Chang CH. 2009. Negative regulation of MyD88-dependent signaling by IL-10 in dendritic cells. Proc Natl Acad Sci U S A 106(43):18327-32. [PubMed: 19815506]  [MGI Ref ID J:153746]

Chang J; Voorhees TJ; Liu Y; Zhao Y; Chang CH. 2010. Interleukin-23 production in dendritic cells is negatively regulated by protein phosphatase 2A. Proc Natl Acad Sci U S A 107(18):8340-5. [PubMed: 20404153]  [MGI Ref ID J:160329]

Charoenlap N; Shen Z; McBee ME; Muthupalani S; Wogan GN; Fox JG; Schauer DB. 2012. Alkyl hydroperoxide reductase is required for Helicobacter cinaedi intestinal colonization and survival under oxidative stress in BALB/c and BALB/c interleukin-10-/- mice. Infect Immun 80(3):921-8. [PubMed: 22184416]  [MGI Ref ID J:182450]

Chassaing B; Koren O; Goodrich JK; Poole AC; Srinivasan S; Ley RE; Gewirtz AT. 2015. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature 519(7541):92-6. [PubMed: 25731162]  [MGI Ref ID J:219843]

Chelvarajan L; Popa D; Liu Y; Getchell TV; Stromberg AJ; Bondada S. 2007. Molecular mechanisms underlying anti-inflammatory phenotype of neonatal splenic macrophages. J Leukoc Biol 82(2):403-16. [PubMed: 17495050]  [MGI Ref ID J:123516]

Chen F; Liu Z; Wu W; Rozo C; Bowdridge S; Millman A; Van Rooijen N; Urban JF Jr; Wynn TA; Gause WC. 2012. An essential role for T(H)2-type responses in limiting acute tissue damage during experimental helminth infection. Nat Med 18(2):260-6. [PubMed: 22245779]  [MGI Ref ID J:181182]

Chen HQ; Shen TY; Zhou YK; Zhang M; Chu ZX; Hang XM; Qin HL. 2010. Lactobacillus plantarum Consumption Increases PepT1-Mediated Amino Acid Absorption by Enhancing Protein Kinase C Activity in Spontaneously Colitic Mice. J Nutr 140(12):2201-6. [PubMed: 20980636]  [MGI Ref ID J:166148]

Chen W; Shu D; Chadwick VS. 2001. Helicobacter pylori infection: mechanism of colonization and functional dyspepsia Reduced colonization of gastric mucosa by Helicobacter pylori in mice deficient in interleukin-10. J Gastroenterol Hepatol 16(4):377-83. [PubMed: 11354274]  [MGI Ref ID J:103513]

Chen X; Duan XS; Xu LJ; Zhao JJ; She ZF; Chen WW; Zheng ZJ; Jiang GD. 2014. Interleukin-10 mediates the neuroprotection of hyperbaric oxygen therapy against traumatic brain injury in mice. Neuroscience 266:235-43. [PubMed: 24291771]  [MGI Ref ID J:210354]

Chiaramonte MG; Hesse M; Cheever AW; Wynn TA. 2000. CpG oligonucleotides can prophylactically immunize against Th2-mediated schistosome egg-induced pathology by an IL-12-independent mechanism. J Immunol 164(2):973-85. [PubMed: 10623847]  [MGI Ref ID J:127058]

Chiaramonte MG; Mentink-Kane M; Jacobson BA; Cheever AW; Whitters MJ; Goad ME; Wong A; Collins M; Donaldson DD; Grusby MJ; Wynn TA. 2003. Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response. J Exp Med 197(6):687-701. [PubMed: 12642601]  [MGI Ref ID J:124413]

Chmiel JF; Konstan MW; Saadane A; Krenicky JE; Lester Kirchner H; Berger M. 2002. Prolonged inflammatory response to acute Pseudomonas challenge in interleukin-10 knockout mice. Am J Respir Crit Care Med 165(8):1176-81. [PubMed: 11956064]  [MGI Ref ID J:103028]

Chow A; Lucas D; Hidalgo A; Mendez-Ferrer S; Hashimoto D; Scheiermann C; Battista M; Leboeuf M; Prophete C; van Rooijen N; Tanaka M; Merad M; Frenette PS. 2011. Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche. J Exp Med 208(2):261-71. [PubMed: 21282381]  [MGI Ref ID J:176846]

Clark K; MacKenzie KF; Petkevicius K; Kristariyanto Y; Zhang J; Choi HG; Peggie M; Plater L; Pedrioli PG; McIver E; Gray NS; Arthur JS; Cohen P. 2012. Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages. Proc Natl Acad Sci U S A 109(42):16986-91. [PubMed: 23033494]  [MGI Ref ID J:190393]

Clementi AH; Gaudy AM; van Rooijen N; Pierce RH; Mooney RA. 2009. Loss of Kupffer cells in diet-induced obesity is associated with increased hepatic steatosis, STAT3 signaling, and further decreases in insulin signaling. Biochim Biophys Acta 1792(11):1062-72. [PubMed: 19699298]  [MGI Ref ID J:164851]

Clemons KV; Grunig G; Sobel RA; Mirels LF; Rennick DM; Stevens DA. 2000. Role of IL-10 in invasive aspergillosis: increased resistance of IL-10 gene knockout mice to lethal systemic aspergillosis Clin Exp Immunol 122(2):186-91. [PubMed: 11091273]  [MGI Ref ID J:65686]

Cohen SJ; Cohen IR; Nussbaum G. 2010. IL-10 mediates resistance to adoptive transfer experimental autoimmune encephalomyelitis in MyD88(-/-) mice. J Immunol 184(1):212-21. [PubMed: 19949074]  [MGI Ref ID J:159039]

Collison LW; Pillai MR; Chaturvedi V; Vignali DA. 2009. Regulatory T cell suppression is potentiated by target T cells in a cell contact, IL-35- and IL-10-dependent manner. J Immunol 182(10):6121-8. [PubMed: 19414764]  [MGI Ref ID J:150297]

Corsetti PP; de Almeida LA; Carvalho NB; Azevedo V; Silva TM; Teixeira HC; Faria AC; Oliveira SC. 2013. Lack of endogenous IL-10 enhances production of proinflammatory cytokines and leads to Brucella abortus clearance in mice. PLoS One 8(9):e74729. [PubMed: 24069337]  [MGI Ref ID J:207535]

Crow AR; Song S; Semple JW; Freedman J; Lazarus AH. 2007. A role for IL-1 receptor antagonist or other cytokines in the acute therapeutic effects of IVIg? Blood 109(1):155-8. [PubMed: 16954498]  [MGI Ref ID J:142178]

Cuff S; Dolton G; Matthews RJ; Gallimore A. 2010. Antigen specificity determines the pro- or antitumoral nature of CD8+ T cells. J Immunol 184(2):607-14. [PubMed: 20007540]  [MGI Ref ID J:159412]

Cyktor JC; Carruthers B; Beamer GL; Turner J. 2013. Clonal expansions of CD8+ T cells with IL-10 secreting capacity occur during chronic Mycobacterium tuberculosis infection. PLoS One 8(3):e58612. [PubMed: 23472214]  [MGI Ref ID J:199388]

Czarneski J; Lin YC; Chong S; McCarthy B; Fernandes H; Parker G; Mansour A; Huppi K; Marti GE; Raveche E. 2004. Studies in NZB IL-10 knockout mice of the requirement of IL-10 for progression of B-cell lymphoma. Leukemia 18(3):597-606. [PubMed: 14712288]  [MGI Ref ID J:88136]

D'Alessio FR; Tsushima K; Aggarwal NR; West EE; Willett MH; Britos MF; Pipeling MR; Brower RG; Tuder RM; McDyer JF; King LS. 2009. CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury. J Clin Invest 119(10):2898-913. [PubMed: 19770521]  [MGI Ref ID J:154630]

D'Alessio S; Correale C; Tacconi C; Gandelli A; Pietrogrande G; Vetrano S; Genua M; Arena V; Spinelli A; Peyrin-Biroulet L; Fiocchi C; Danese S. 2014. VEGF-C-dependent stimulation of lymphatic function ameliorates experimental inflammatory bowel disease. J Clin Invest 124(9):3863-78. [PubMed: 25105363]  [MGI Ref ID J:215745]

D'Orazio TJ; Niederkorn JY. 1998. A novel role for TGF-beta and IL-10 in the induction of immune privilege. J Immunol 160(5):2089-98. [PubMed: 9498745]  [MGI Ref ID J:111362]

Dai H; Wan N; Zhang S; Moore Y; Wan F; Dai Z. 2010. Cutting edge: Programmed Death-1 defines CD8+ CD122+ T cells as regulatory versus memory T cells. J Immunol 185(2):803-7. [PubMed: 20548035]  [MGI Ref ID J:161937]

Dai WJ; Kohler G; Brombacher F. 1997. Both innate and acquired immunity to Listeria monocytogenes infection are increased in IL-10-deficient mice. J Immunol 158(5):2259-67. [PubMed: 9036973]  [MGI Ref ID J:110855]

Dann SM; Le C; Choudhury BK; Liu H; Saldarriaga O; Hanson EM; Cong Y; Eckmann L. 2014. Attenuation of intestinal inflammation in interleukin-10-deficient mice infected with Citrobacter rodentium. Infect Immun 82(5):1949-58. [PubMed: 24566625]  [MGI Ref ID J:209888]

Darling AR; Freyschmidt EJ; Burton OT; Koleoglou KJ; Oyoshi MK; Oettgen HC. 2014. IL-10 suppresses IL-17-mediated dermal inflammation and reduces the systemic burden of Vaccinia virus in a mouse model of eczema vaccinatum. Clin Immunol 150(2):153-60. [PubMed: 24412909]  [MGI Ref ID J:209389]

Darragh J; Ananieva O; Courtney A; Elcombe S; Arthur JS. 2010. MSK1 regulates the transcription of IL-1ra in response to TLR activation in macrophages. Biochem J 425(3):595-602. [PubMed: 19922413]  [MGI Ref ID J:159202]

Das G; Augustine MM; Das J; Bottomly K; Ray P; Ray A. 2003. An important regulatory role for CD4+CD8 alpha alpha T cells in the intestinal epithelial layer in the prevention of inflammatory bowel disease. Proc Natl Acad Sci U S A 100(9):5324-9. [PubMed: 12695566]  [MGI Ref ID J:83283]

Davidson NJ; Fort MM; Muller W; Leach MW; Rennick DM. 2000. Chronic colitis in IL-10-/- mice: insufficient counter regulation of a Th1 response Int Rev Immunol 19(1):91-121. [PubMed: 10723680]  [MGI Ref ID J:61253]

Davidson NJ; Leach MW; Fort MM; Thompson-Snipes L; Kuhn R; Muller W; Berg DJ; Rennick DM. 1996. T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice. J Exp Med 184(1):241-51. [PubMed: 8691138]  [MGI Ref ID J:34035]

Davies PS; Powell AE; Swain JR; Wong MH. 2009. Inflammation and proliferation act together to mediate intestinal cell fusion. PLoS One 4(8):e6530. [PubMed: 19657387]  [MGI Ref ID J:152479]

De Fazio SR; Gozzo JJ. 2000. Role of graft interleukin-10 expression in the tolerogenicity of neonatal skin allografts Transplantation 70(9):1371-7. [PubMed: 11087155]  [MGI Ref ID J:65782]

Deepe GS Jr; Buesing WR. 2012. Deciphering the pathways of death of Histoplasma capsulatum-infected macrophages: implications for the immunopathogenesis of early infection. J Immunol 188(1):334-44. [PubMed: 22102723]  [MGI Ref ID J:180361]

Deepe GS Jr; Gibbons RS. 2003. Protective and memory immunity to Histoplasma capsulatum in the absence of IL-10. J Immunol 171(10):5353-62. [PubMed: 14607938]  [MGI Ref ID J:117988]

Del Sero G; Mencacci A; Cenci E; d'Ostiani CF; Montagnoli C; Bacci A; Mosci P; Kopf M; Romani L. 1999. Antifungal type 1 responses are upregulated in IL-10-deficient mice. Microbes Infect 1(14):1169-80. [PubMed: 10580272]  [MGI Ref ID J:106542]

Demangel C; Bertolino P; Britton WJ. 2002. Autocrine IL-10 impairs dendritic cell (DC)-derived immune responses to mycobacterial infection by suppressing DC trafficking to draining lymph nodes and local IL-12 production. Eur J Immunol 32(4):994-1002. [PubMed: 11920565]  [MGI Ref ID J:75998]

Demols A; Van Laethem JL; Quertinmont E; Degraef C; Delhaye M; Geerts A; Deviere J. 2002. Endogenous interleukin-10 modulates fibrosis and regeneration in experimental chronic pancreatitis. Am J Physiol Gastrointest Liver Physiol 282(6):G1105-12. [PubMed: 12016137]  [MGI Ref ID J:108286]

Deng B; Wehling-Henricks M; Villalta SA; Wang Y; Tidball JG. 2012. IL-10 triggers changes in macrophage phenotype that promote muscle growth and regeneration. J Immunol 189(7):3669-80. [PubMed: 22933625]  [MGI Ref ID J:190351]

Deng J; Yuan S; Pennati A; Murphy J; Wu JH; Lawson D; Galipeau J. 2014. Engineered fusokine GIFT4 licenses the ability of B cells to trigger a tumoricidal T-cell response. Cancer Res 74(15):4133-44. [PubMed: 24938765]  [MGI Ref ID J:213719]

Denning TL; Wang YC; Patel SR; Williams IR; Pulendran B. 2007. Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses. Nat Immunol 8(10):1086-94. [PubMed: 17873879]  [MGI Ref ID J:125258]

Dennis KL; Wang Y; Blatner NR; Wang S; Saadalla A; Trudeau E; Roers A; Weaver CT; Lee JJ; Gilbert JA; Chang EB; Khazaie K. 2013. Adenomatous polyps are driven by microbe-instigated focal inflammation and are controlled by IL-10-producing T cells. Cancer Res 73(19):5905-13. [PubMed: 23955389]  [MGI Ref ID J:202608]

Dercamp C; Chemin K; Caux C; Trinchieri G; Vicari AP. 2005. Distinct and overlapping roles of interleukin-10 and CD25+ regulatory T cells in the inhibition of antitumor CD8 T-cell responses. Cancer Res 65(18):8479-86. [PubMed: 16166328]  [MGI Ref ID J:101610]

Di Marco R; Xiang M; Zaccone P; Leonardi C; Franco S; Meroni P; Nicoletti F. 1999. Concanavalin A-induced hepatitis in mice is prevented by interleukin (IL)-10 and exacerbated by endogenous IL-10 deficiency Autoimmunity 31(2):75-83. [PubMed: 10680745]  [MGI Ref ID J:60463]

DiFedele LM; He J; Bonkowski EL; Han X; Held MA; Bohan A; Menon RK; Denson LA. 2005. Tumor necrosis factor alpha blockade restores growth hormone signaling in murine colitis. Gastroenterology 128(5):1278-91. [PubMed: 15887111]  [MGI Ref ID J:124938]

Dieleman LA; Arends A; Tonkonogy SL; Goerres MS; Craft DW; Grenther W; Sellon RK; Balish E; Sartor RB. 2000. Helicobacter hepaticus does not induce or potentiate colitis in interleukin-10-deficient mice. Infect Immun 68(9):5107-13. [PubMed: 10948132]  [MGI Ref ID J:64076]

Dresner-Pollak R; Gelb N; Rachmilewitz D; Karmeli F; Weinreb M. 2004. Interleukin 10-deficient mice develop osteopenia, decreased bone formation, and mechanical fragility of long bones. Gastroenterology 127(3):792-801. [PubMed: 15362035]  [MGI Ref ID J:93577]

Dube PE; Yan F; Punit S; Girish N; McElroy SJ; Washington MK; Polk DB. 2012. Epidermal growth factor receptor inhibits colitis-associated cancer in mice. J Clin Invest 122(8):2780-92. [PubMed: 22772467]  [MGI Ref ID J:190076]

Dubois B; Chapat L; Goubier A; Papiernik M; Nicolas JF; Kaiserlian D. 2003. Innate CD4+CD25+ regulatory T cells are required for oral tolerance and inhibition of CD8+ T cells mediating skin inflammation. Blood 102(9):3295-301. [PubMed: 12855551]  [MGI Ref ID J:115675]

Duell BL; Carey AJ; Tan CK; Cui X; Webb RI; Totsika M; Schembri MA; Derrington P; Irving-Rodgers H; Brooks AJ; Cripps AW; Crowley M; Ulett GC. 2012. Innate transcriptional networks activated in bladder in response to uropathogenic Escherichia coli drive diverse biological pathways and rapid synthesis of IL-10 for defense against bacterial urinary tract infection. J Immunol 188(2):781-92. [PubMed: 22184725]  [MGI Ref ID J:180771]

Dutta A; Huang CT; Chen TC; Lin CY; Chiu CH; Lin YC; Chang CS; He YC. 2015. IL-10 inhibits neuraminidase-activated TGF-beta and facilitates Th1 phenotype during early phase of infection. Nat Commun 6:6374. [PubMed: 25728041]  [MGI Ref ID J:221784]

Eaton KA; Mefford M; Thevenot T. 2001. The role of T cell subsets and cytokines in the pathogenesis of Helicobacter pylori gastritis in mice. J Immunol 166(12):7456-61. [PubMed: 11390498]  [MGI Ref ID J:124425]

Eckmann L; Nebelsiek T; Fingerle AA; Dann SM; Mages J; Lang R; Robine S; Kagnoff MF; Schmid RM; Karin M; Arkan MC; Greten FR. 2008. Opposing functions of IKKbeta during acute and chronic intestinal inflammation. Proc Natl Acad Sci U S A 105(39):15058-63. [PubMed: 18815378]  [MGI Ref ID J:143368]

Edmunds SJ; Roy NC; Love DR; Laing WA. 2011. Kiwifruit extracts inhibit cytokine production by lipopolysaccharide-activated macrophages, and intestinal epithelial cells isolated from IL10 gene deficient mice. Cell Immunol 270(1):70-9. [PubMed: 21600571]  [MGI Ref ID J:176754]

El Kasmi KC; Holst J; Coffre M; Mielke L; de Pauw A; Lhocine N; Smith AM; Rutschman R; Kaushal D; Shen Y; Suda T; Donnelly RP; Myers MG Jr; Alexander W; Vignali DA; Watowich SS; Ernst M; Hilton DJ; Murray PJ. 2006. General nature of the STAT3-activated anti-inflammatory response. J Immunol 177(11):7880-8. [PubMed: 17114459]  [MGI Ref ID J:140695]

El Kasmi KC; Smith AM; Williams L; Neale G; Panopolous A; Watowich SS; Hacker H; Foxwell BM; Murray PJ. 2007. Cutting edge: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway. J Immunol 179(11):7215-9. [PubMed: 18025162]  [MGI Ref ID J:133009]

Elcombe SE; Naqvi S; Van Den Bosch MW; MacKenzie KF; Cianfanelli F; Brown GD; Arthur JS. 2013. Dectin-1 regulates IL-10 production via a MSK1/2 and CREB dependent pathway and promotes the induction of regulatory macrophage markers. PLoS One 8(3):e60086. [PubMed: 23533666]  [MGI Ref ID J:199902]

Elliott DE; Setiawan T; Metwali A; Blum A; Urban JF Jr; Weinstock JV. 2004. Heligmosomoides polygyrus inhibits established colitis in IL-10-deficient mice. Eur J Immunol 34(10):2690. [PubMed: 15368285]  [MGI Ref ID J:92338]

Eming SA; Werner S; Bugnon P; Wickenhauser C; Siewe L; Utermohlen O; Davidson JM; Krieg T; Roers A. 2007. Accelerated wound closure in mice deficient for interleukin-10. Am J Pathol 170(1):188-202. [PubMed: 17200193]  [MGI Ref ID J:117053]

Endharti AT; Rifa'I M st; Shi Z; Fukuoka Y; Nakahara Y; Kawamoto Y; Takeda K; Isobe K; Suzuki H. 2005. Cutting edge: CD8+CD122+ regulatory T cells produce IL-10 to suppress IFN-gamma production and proliferation of CD8+ T cells. J Immunol 175(11):7093-7. [PubMed: 16301610]  [MGI Ref ID J:122202]

Ermann J; Garrett WS; Kuchroo J; Rourida K; Glickman JN; Bleich A; Glimcher LH. 2011. Severity of innate immune-mediated colitis is controlled by the cytokine deficiency-induced colitis susceptibility-1 (Cdcs1) locus. Proc Natl Acad Sci U S A 108(17):7137-41. [PubMed: 21482794]  [MGI Ref ID J:171340]

Ertelt JM; Buyukbasaran EZ; Jiang TT; Rowe JH; Xin L; Way SS. 2013. B7-1/B7-2 blockade overrides the activation of protective CD8 T cells stimulated in the absence of Foxp3+ regulatory T cells. J Leukoc Biol 94(2):367-76. [PubMed: 23744647]  [MGI Ref ID J:204423]

Fang Y; Sharp GC; Braley-Mullen H. 2008. Interleukin-10 promotes resolution of granulomatous experimental autoimmune thyroiditis. Am J Pathol 172(6):1591-602. [PubMed: 18467701]  [MGI Ref ID J:136188]

Farmer MA; Sundberg JP; Bristol IJ; Churchill GA; Li R; Elson CO; Leiter EH. 2001. A major quantitative trait locus on chromosome 3 controls colitis severity in IL-10-deficient mice. Proc Natl Acad Sci U S A 98(24):13820-5. [PubMed: 11707574]  [MGI Ref ID J:72978]

Fasnacht N; Greweling MC; Bollati-Fogolin M; Schippers A; Muller W. 2009. T-cell-specific deletion of gp130 renders the highly susceptible IL-10-deficient mouse resistant to intestinal nematode infection. Eur J Immunol 39(8):2173-83. [PubMed: 19593768]  [MGI Ref ID J:151695]

Fassbender M; Gerlitzki B; Ullrich N; Lupp C; Klein M; Radsak MP; Schmitt E; Bopp T; Schild H. 2010. Cyclic adenosine monophosphate and IL-10 coordinately contribute to nTreg cell-mediated suppression of dendritic cell activation. Cell Immunol 265(2):91-6. [PubMed: 20728078]  [MGI Ref ID J:165335]

Feng D; Wang Y; Xu Y; Luo Q; Lan B; Xu L. 2009. Interleukin 10 deficiency exacerbates halothane induced liver injury by increasing interleukin 8 expression and neutrophil infiltration. Biochem Pharmacol 77(2):277-84. [PubMed: 18940183]  [MGI Ref ID J:144654]

Feng P; Chai J; Zhou M; Simon N; Huang L; Wang H. 2014. Interleukin-10 is produced by a specific subset of taste receptor cells and critical for maintaining structural integrity of mouse taste buds. J Neurosci 34(7):2689-701. [PubMed: 24523558]  [MGI Ref ID J:206936]

Fillatreau S; Sweenie CH; McGeachy MJ; Gray D; Anderton SM. 2002. B cells regulate autoimmunity by provision of IL-10. Nat Immunol 3(10):944-50. [PubMed: 12244307]  [MGI Ref ID J:79219]

Fitzgerald DC; Zhang GX; El-Behi M; Fonseca-Kelly Z; Li H; Yu S; Saris CJ; Gran B; Ciric B; Rostami A. 2007. Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells. Nat Immunol 8(12):1372-9. [PubMed: 17994023]  [MGI Ref ID J:127773]

Flanagan K; Modrusan Z; Cornelius J; Chavali A; Kasman I; Komuves L; Mo L; Diehl L. 2008. Intestinal Epithelial Cell Up-Regulation of LY6 Molecules during Colitis Results in Enhanced Chemokine Secretion. J Immunol 180(6):3874-81. [PubMed: 18322195]  [MGI Ref ID J:133031]

Flano E; Kayhan B; Woodland DL; Blackman MA. 2005. Infection of dendritic cells by a gamma2-herpesvirus induces functional modulation. J Immunol 175(5):3225-34. [PubMed: 16116213]  [MGI Ref ID J:113212]

Florek M; Sega EI; Leveson-Gower DB; Baker J; Muller AM; Schneidawind D; Meyer E; Negrin RS. 2014. Autologous apoptotic cells preceding transplantation enhance survival in lethal murine graft-versus-host models. Blood 124(11):1832-42. [PubMed: 25030062]  [MGI Ref ID J:214627]

Foulds KE; Rotte MJ; Seder RA. 2006. IL-10 is required for optimal CD8 T cell memory following Listeria monocytogenes infection. J Immunol 177(4):2565-74. [PubMed: 16888018]  [MGI Ref ID J:138354]

Frazier WJ; Wang X; Wancket LM; Li XA; Meng X; Nelin LD; Cato AC; Liu Y. 2009. Increased inflammation, impaired bacterial clearance, and metabolic disruption after gram-negative sepsis in Mkp-1-deficient mice. J Immunol 183(11):7411-9. [PubMed: 19890037]  [MGI Ref ID J:157403]

Freitas do Rosario AP; Lamb T; Spence P; Stephens R; Lang A; Roers A; Muller W; O'Garra A; Langhorne J. 2012. IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infection. J Immunol 188(3):1178-90. [PubMed: 22205023]  [MGI Ref ID J:180758]

French AR; Sjolin H; Kim S; Koka R; Yang L; Young DA; Cerboni C; Tomasello E; Ma A; Vivier E; Karre K; Yokoyama WM. 2006. DAP12 signaling directly augments proproliferative cytokine stimulation of NK cells during viral infections. J Immunol 177(8):4981-90. [PubMed: 17015680]  [MGI Ref ID J:139300]

Freyschmidt-Paul P; McElwee KJ; Happle R; Kissling S; Wenzel E; Sundberg JP; Zoller M; Hoffmann R. 2002. Interleukin-10-deficient mice are less susceptible to the induction of alopecia areata. J Invest Dermatol 119(4):980-2. [PubMed: 12406350]  [MGI Ref ID J:80138]

Froicu M; Weaver V; Wynn TA; McDowell MA; Welsh JE; Cantorna MT. 2003. A crucial role for the vitamin d receptor in experimental inflammatory bowel diseases. Mol Endocrinol 17(12):2386-92. [PubMed: 14500760]  [MGI Ref ID J:86860]

Froicu M; Zhu Y; Cantorna MT. 2006. Vitamin D receptor is required to control gastrointestinal immunity in IL-10 knockout mice. Immunology 117(3):310-8. [PubMed: 16476050]  [MGI Ref ID J:107077]

Fujiwara H; Yamazaki T; Uzawa A; Nagata K; Kobayashi Y. 2008. Transient infiltration of neutrophils into the thymus following whole-body X-ray irradiation in IL-10 knockout mice. Biochem Biophys Res Commun 369(2):432-6. [PubMed: 18291100]  [MGI Ref ID J:134174]

Gabrysova L; Nicolson KS; Streeter HB; Verhagen J; Sabatos-Peyton CA; Morgan DJ; Wraith DC. 2009. Negative feedback control of the autoimmune response through antigen-induced differentiation of IL-10-secreting Th1 cells. J Exp Med 206(8):1755-67. [PubMed: 19635862]  [MGI Ref ID J:151484]

Gaddi PJ; Crane MJ; Kamanaka M; Flavell RA; Yap GS; Salazar-Mather TP. 2012. IL-10 mediated regulation of liver inflammation during acute murine cytomegalovirus infection. PLoS One 7(8):e42850. [PubMed: 22880122]  [MGI Ref ID J:189817]

Gao Y; Herndon JM; Zhang H; Griffith TS; Ferguson TA. 1998. Antiinflammatory effects of CD95 ligand (FasL)-induced apoptosis. J Exp Med 188(5):887-96. [PubMed: 9730890]  [MGI Ref ID J:112021]

Gazzinelli RT; Wysocka M; Hieny S; Scharton-Kersten T; Cheever A; Kuhn R; Muller W; Trinchieri G; Sher A. 1996. In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha. J Immunol 157(2):798-805. [PubMed: 8752931]  [MGI Ref ID J:34041]

Genovese T; Esposito E; Mazzon E; Di Paola R; Caminiti R; Bramanti P; Cappelani A; Cuzzocrea S. 2009. Absence of endogenous interleukin-10 enhances secondary inflammatory process after spinal cord compression injury in mice. J Neurochem 108(6):1360-72. [PubMed: 19183262]  [MGI Ref ID J:146854]

Getahun A; Smith MJ; Kogut I; van Dyk LF; Cambier JC. 2012. Retention of anergy and inhibition of antibody responses during acute gamma herpesvirus 68 infection. J Immunol 189(6):2965-74. [PubMed: 22904300]  [MGI Ref ID J:189918]

Getts DR; Turley DM; Smith CE; Harp CT; McCarthy D; Feeney EM; Getts MT; Martin AJ; Luo X; Terry RL; King NJ; Miller SD. 2011. Tolerance induced by apoptotic antigen-coupled leukocytes is induced by PD-L1+ and IL-10-producing splenic macrophages and maintained by T regulatory cells. J Immunol 187(5):2405-17. [PubMed: 21821796]  [MGI Ref ID J:179266]

Giachini FR; Zemse SM; Carneiro FS; Lima VV; Carneiro ZN; Callera GE; Ergul A; Webb RC; Tostes RC. 2009. Interleukin-10 attenuates vascular responses to endothelin-1 via effects on ERK1/2-dependent pathway. Am J Physiol Heart Circ Physiol 296(2):H489-96. [PubMed: 19074677]  [MGI Ref ID J:146372]

Gjertsson I; Hultgren OH; Tarkowski A. 2002. Interleukin-10 ameliorates the outcome of Staphylococcus aureus arthritis by promoting bacterial clearance. Clin Exp Immunol 130(3):409-14. [PubMed: 12452830]  [MGI Ref ID J:131892]

Gonnella PA; Waldner HP; Kodali D; Weiner HL. 2004. Induction of low dose oral tolerance in IL-10 deficient mice with experimental autoimmune encephalomyelitis. J Autoimmun 23(3):193-200. [PubMed: 15501390]  [MGI Ref ID J:93230]

Gonzalez A; Andre-Schmutz I; Carnaud C; Mathis D; Benoist C. 2001. Damage control, rather than unresponsiveness, effected by protective DX5+ T cells in autoimmune diabetes. Nat Immunol 2(12):1117-25. [PubMed: 11713466]  [MGI Ref ID J:109860]

Gonzalez-Navajas JM; Fine S; Law J; Datta SK; Nguyen KP; Yu M; Corr M; Katakura K; Eckman L; Lee J; Raz E. 2010. TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice. J Clin Invest 120(2):570-81. [PubMed: 20051628]  [MGI Ref ID J:156686]

Gotoh K; Inoue M; Masaki T; Chiba S; Shimasaki T; Ando H; Fujiwara K; Katsuragi I; Kakuma T; Seike M; Sakata T; Yoshimatsu H. 2012. A novel anti-inflammatory role for spleen-derived interleukin-10 in obesity-induced hypothalamic inflammation. J Neurochem 120(5):752-64. [PubMed: 22146087]  [MGI Ref ID J:182778]

Gotoh K; Inoue M; Masaki T; Chiba S; Shimasaki T; Ando H; Fujiwara K; Katsuragi I; Kakuma T; Seike M; Sakata T; Yoshimatsu H. 2012. A novel anti-inflammatory role for spleen-derived interleukin-10 in obesity-induced inflammation in white adipose tissue and liver. Diabetes 61(8):1994-2003. [PubMed: 22648387]  [MGI Ref ID J:208454]

Gourdy P; Schambourg A; Filipe C; Douin-Echinard V; Garmy-Susini B; Calippe B; Terce F; Bayard F; Arnal JF. 2007. Transforming growth factor activity is a key determinant for the effect of estradiol on fatty streak deposit in hypercholesterolemic mice. Arterioscler Thromb Vasc Biol 27(10):2214-21. [PubMed: 17690314]  [MGI Ref ID J:134877]

Grilli M; Barbieri I; Basudev H; Brusa R; Casati C; Lozza G; Ongini E. 2000. Interleukin-10 modulates neuronal threshold of vulnerability to ischaemic damage. Eur J Neurosci 12(7):2265-72. [PubMed: 10947805]  [MGI Ref ID J:108086]

Grimbaldeston MA; Nakae S; Kalesnikoff J; Tsai M; Galli SJ. 2007. Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B. Nat Immunol 8(10):1095-104. [PubMed: 17767162]  [MGI Ref ID J:125267]

Gross O; Yazdi AS; Thomas CJ; Masin M; Heinz LX; Guarda G; Quadroni M; Drexler SK; Tschopp J. 2012. Inflammasome activators induce interleukin-1alpha secretion via distinct pathways with differential requirement for the protease function of caspase-1. Immunity 36(3):388-400. [PubMed: 22444631]  [MGI Ref ID J:187333]

Grunig G; Corry DB; Leach MW; Seymour BW; Kurup VP; Rennick DM. 1997. Interleukin-10 is a natural suppressor of cytokine production and inflammation in a murine model of allergic bronchopulmonary aspergillosis. J Exp Med 185(6):1089-99. [PubMed: 9091582]  [MGI Ref ID J:39230]

Gu Y; Yang J; Ouyang X; Liu W; Li H; Yang J; Bromberg J; Chen SH; Mayer L; Unkeless JC; Xiong H. 2008. Interleukin 10 suppresses Th17 cytokines secreted by macrophages and T cells. Eur J Immunol 38(7):1807-13. [PubMed: 18506885]  [MGI Ref ID J:137290]

Guarda G; Braun M; Staehli F; Tardivel A; Mattmann C; Forster I; Farlik M; Decker T; Du Pasquier RA; Romero P; Tschopp J. 2011. Type I interferon inhibits interleukin-1 production and inflammasome activation. Immunity 34(2):213-23. [PubMed: 21349431]  [MGI Ref ID J:168972]

Gudmundsson G; Bosch A; Davidson BL; Berg DJ; Hunninghake GW. 1998. Interleukin-10 modulates the severity of hypersensitivity pneumonitis in mice. Am J Respir Cell Mol Biol 19(5):812-8. [PubMed: 9806746]  [MGI Ref ID J:114214]

Guerrero A; Fries BC. 2008. Phenotypic switching in Cryptococcus neoformans contributes to virulence by changing the immunological host response. Infect Immun 76(9):4322-31. [PubMed: 18591227]  [MGI Ref ID J:138887]

Guilbault C; Stotland P; Lachance C; Tam M; Keller A; Thompson-Snipes L; Cowley E; Hamilton TA; Eidelman DH; Stevenson MM; Radzioch D. 2002. Influence of gender and interleukin-10 deficiency on the inflammatory response during lung infection with Pseudomonas aeruginosa in mice. Immunology 107(3):297-305. [PubMed: 12423305]  [MGI Ref ID J:113617]

Guilliams M; Movahedi K; Bosschaerts T; VandenDriessche T; Chuah MK; Herin M; Acosta-Sanchez A; Ma L; Moser M; Van Ginderachter JA; Brys L; De Baetselier P; Beschin A. 2009. IL-10 dampens TNF/inducible nitric oxide synthase-producing dendritic cell-mediated pathogenicity during parasitic infection. J Immunol 182(2):1107-18. [PubMed: 19124754]  [MGI Ref ID J:143483]

Guilliams M; Oldenhove G; Noel W; Herin M; Brys L; Loi P; Flamand V; Moser M; De Baetselier P; Beschin A. 2007. African trypanosomiasis: naturally occurring regulatory T cells favor trypanotolerance by limiting pathology associated with sustained type 1 inflammation. J Immunol 179(5):2748-57. [PubMed: 17709488]  [MGI Ref ID J:151836]

Guillot-Sestier MV; Doty KR; Gate D; Rodriguez J Jr; Leung BP; Rezai-Zadeh K; Town T. 2015. Il10 deficiency rebalances innate immunity to mitigate Alzheimer-like pathology. Neuron 85(3):534-48. [PubMed: 25619654]  [MGI Ref ID J:219701]

Guindi C; Menard M; Cloutier A; Gaudreau S; Besin G; Larivee P; McDonald PP; Dupuis G; Amrani A. 2012. Differential role of NF-kappaB, ERK1/2 and AP-1 in modulating the immunoregulatory functions of bone marrow-derived dendritic cells from NOD mice. Cell Immunol 272(2):259-68. [PubMed: 22070873]  [MGI Ref ID J:181379]

Gulbransen BD; Bashashati M; Hirota SA; Gui X; Roberts JA; MacDonald JA; Muruve DA; McKay DM; Beck PL; Mawe GM; Thompson RJ; Sharkey KA. 2012. Activation of neuronal P2X7 receptor-pannexin-1 mediates death of enteric neurons during colitis. Nat Med 18(4):600-4. [PubMed: 22426419]  [MGI Ref ID J:183386]

Gunnett CA; Berg DJ; Faraci FM; Feuerstein G. 1999. Vascular effects of lipopolysaccharide are enhanced in interleukin-10-deficient mice. Stroke 30(10):2191-5; discussion 2195-6. [PubMed: 10512928]  [MGI Ref ID J:59742]

Gunnett CA; Heistad DD; Berg DJ; Faraci FM. 2000. IL-10 deficiency increases superoxide and endothelial dysfunction during inflammation Am J Physiol Heart Circ Physiol 279(4):H1555-62. [PubMed: 11009441]  [MGI Ref ID J:65225]

Gunnett CA; Lund DD; Faraci FM; Heistad DD. 2005. Vascular interleukin-10 protects against LPS-induced vasomotor dysfunction. Am J Physiol Heart Circ Physiol 289(2):H624-30. [PubMed: 16014616]  [MGI Ref ID J:100322]

Guo Z; Wen Z; Qin A; Zhou Y; Liao Z; Liu Z; Liang Y; Ren T; Xu L. 2013. Antisense Oligonucleotide Treatment Enhances the Recovery of Acute Lung Injury through IL-10-Secreting M2-like Macrophage-Induced Expansion of CD4+ Regulatory T Cells. J Immunol 190(8):4337-48. [PubMed: 23514739]  [MGI Ref ID J:195286]

Haag LM; Fischer A; Otto B; Plickert R; Kuhl AA; Gobel UB; Bereswill S; Heimesaat MM. 2012. Campylobacter jejuni induces acute enterocolitis in gnotobiotic IL-10-/- mice via Toll-like-receptor-2 and -4 signaling. PLoS One 7(7):e40761. [PubMed: 22808254]  [MGI Ref ID J:189623]

Haggqvist B; Hultman P. 2005. Interleukin-10 in murine metal-induced systemic autoimmunity. Clin Exp Immunol 141(3):422-31. [PubMed: 16045731]  [MGI Ref ID J:100639]

Hale LP; Greer PK. 2012. A novel murine model of inflammatory bowel disease and inflammation-associated colon cancer with ulcerative colitis-like features. PLoS One 7(7):e41797. [PubMed: 22848611]  [MGI Ref ID J:189696]

Hale LP; Perera D; Gottfried MR; Maggio-Price L; Srinivasan S; Marchuk D. 2007. Neonatal co-infection with helicobacter species markedly accelerates the development of inflammation-associated colonic neoplasia in IL-10(-/-) mice. Helicobacter 12(6):598-604. [PubMed: 18001399]  [MGI Ref ID J:141450]

Hall AO; Beiting DP; Tato C; John B; Oldenhove G; Lombana CG; Pritchard GH; Silver JS; Bouladoux N; Stumhofer JS; Harris TH; Grainger J; Wojno ED; Wagage S; Roos DS; Scott P; Turka LA; Cherry S; Reiner SL; Cua D; Belkaid Y; Elloso MM; Hunter CA. 2012. The Cytokines Interleukin 27 and Interferon-gamma Promote Distinct Treg Cell Populations Required to Limit Infection-Induced Pathology. Immunity 37(3):511-23. [PubMed: 22981537]  [MGI Ref ID J:187660]

Hamano S; Asgharpour A; Stroup SE; Wynn TA; Leiter EH; Houpt E. 2006. Resistance of C57BL/6 mice to amoebiasis is mediated by nonhemopoietic cells but requires hemopoietic IL-10 production. J Immunol 177(2):1208-13. [PubMed: 16818779]  [MGI Ref ID J:134990]

Hammer M; Mages J; Dietrich H; Schmitz F; Striebel F; Murray PJ; Wagner H; Lang R. 2005. Control of dual-specificity phosphatase-1 expression in activated macrophages by IL-10. Eur J Immunol 35(10):2991-3001. [PubMed: 16184516]  [MGI Ref ID J:113501]

Hammer M; Mages J; Dietrich H; Servatius A; Howells N; Cato AC; Lang R. 2006. Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock. J Exp Med 203(1):15-20. [PubMed: 16380512]  [MGI Ref ID J:118833]

Hao S; Yuan J; Xu S; Munegowda MA; Deng Y; Gordon J; Xing Z; Xiang J. 2008. Antigen specificity acquisition of adoptive CD4+ regulatory T cells via acquired peptide-MHC class I complexes. J Immunol 181(4):2428-37. [PubMed: 18684933]  [MGI Ref ID J:140189]

Harrington LE; Hatton RD; Mangan PR; Turner H; Murphy TL; Murphy KM; Weaver CT. 2005. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 6(11):1123-32. [PubMed: 16200070]  [MGI Ref ID J:112601]

Hasegawa E; Oshima Y; Takeda A; Saeki K; Yoshida H; Sonoda KH; Ishibashi T. 2012. IL-27 inhibits pathophysiological intraocular neovascularization due to laser burn. J Leukoc Biol 91(2):267-73. [PubMed: 22045869]  [MGI Ref ID J:181046]

Hasko G; Szabo C; Nemeth ZH; Salzman AL; Vizi ES. 1998. Suppression of IL-12 production by phosphodiesterase inhibition in murine endotoxemia is IL-10 independent. Eur J Immunol 28(2):468-72. [PubMed: 9521054]  [MGI Ref ID J:46196]

Hata H; Sakaguchi N; Yoshitomi H; Iwakura Y; Sekikawa K; Azuma Y; Kanai C; Moriizumi E; Nomura T; Nakamura T; Sakaguchi S. 2004. Distinct contribution of IL-6, TNF-alpha, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice. J Clin Invest 114(4):582-8. [PubMed: 15314695]  [MGI Ref ID J:92002]

Hayasaka D; Shirai K; Aoki K; Nagata N; Simantini DS; Kitaura K; Takamatsu Y; Gould E; Suzuki R; Morita K. 2013. TNF-alpha acts as an immunoregulator in the mouse brain by reducing the incidence of severe disease following Japanese encephalitis virus infection. PLoS One 8(8):e71643. [PubMed: 23940775]  [MGI Ref ID J:204932]

Hegazi RA; Mady HH; Melhem MF; Sepulveda AR; Mohi M; Kandil HM. 2003. Celecoxib and rofecoxib potentiate chronic colitis and premalignant changes in interleukin 10 knockout mice. Inflamm Bowel Dis 9(4):230-6. [PubMed: 12902846]  [MGI Ref ID J:85702]

Hegazi RA; Rao KN; Mayle A; Sepulveda AR; Otterbein LE; Plevy SE. 2005. Carbon monoxide ameliorates chronic murine colitis through a heme oxygenase 1-dependent pathway. J Exp Med 202(12):1703-13. [PubMed: 16365149]  [MGI Ref ID J:118826]

Heidegger S; Kirchner SK; Stephan N; Bohn B; Suhartha N; Hotz C; Anz D; Sandholzer N; Stecher B; Russmann H; Endres S; Bourquin C. 2013. TLR activation excludes circulating naive CD8+ T cells from gut-associated lymphoid organs in mice. J Immunol 190(10):5313-20. [PubMed: 23589622]  [MGI Ref ID J:202547]

Helmby H; Grencis RK. 2003. Contrasting roles for IL-10 in protective immunity to different life cycle stages of intestinal nematode parasites. Eur J Immunol 33(9):2382-90. [PubMed: 12938214]  [MGI Ref ID J:85455]

Hernandez Y; Arora S; Erb-Downward JR; McDonald RA; Toews GB; Huffnagle GB. 2005. Distinct roles for IL-4 and IL-10 in regulating T2 immunity during allergic bronchopulmonary mycosis. J Immunol 174(2):1027-36. [PubMed: 15634927]  [MGI Ref ID J:95831]

Hesse M; Modolell M; La Flamme AC; Schito M; Fuentes JM; Cheever AW; Pearce EJ; Wynn TA. 2001. Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of L-arginine metabolism. J Immunol 167(11):6533-44. [PubMed: 11714822]  [MGI Ref ID J:72822]

Hickey MJ; Issekutz AC; Reinhardt PH; Fedorak RN; Kubes P. 1998. Endogenous interleukin-10 regulates hemodynamic parameters, leukocyte-endothelial cell interactions, and microvascular permeability during endotoxemia. Circ Res 83(11):1124-31. [PubMed: 9831707]  [MGI Ref ID J:114199]

Hirotani T; Lee PY; Kuwata H; Yamamoto M; Matsumoto M; Kawase I; Akira S; Takeda K. 2005. The nuclear IkappaB protein IkappaBNS selectively inhibits lipopolysaccharide-induced IL-6 production in macrophages of the colonic lamina propria. J Immunol 174(6):3650-7. [PubMed: 15749903]  [MGI Ref ID J:97704]

Hoentjen F; Sartor RB; Ozaki M; Jobin C. 2005. STAT3 regulates NF-kappaB recruitment to the IL-12p40 promoter in dendritic cells. Blood 105(2):689-96. [PubMed: 15251981]  [MGI Ref ID J:96516]

Hoffmann KF; Cheever AW; Wynn TA. 2000. IL-10 and the dangers of immune polarization: excessive type 1 and type 2 cytokine responses induce distinct forms of lethal immunopathology in murine schistosomiasis. J Immunol 164(12):6406-16. [PubMed: 10843696]  [MGI Ref ID J:124519]

Hoffmann KF; James SL; Cheever AW; Wynn TA. 1999. Studies with double cytokine-deficient mice reveal that highly polarized Th1- and Th2-type cytokine and antibody responses contribute equally to vaccine-induced immunity to Schistosoma mansoni. J Immunol 163(2):927-38. [PubMed: 10395689]  [MGI Ref ID J:56157]

Horikawa M; Weimer ET; DiLillo DJ; Venturi GM; Spolski R; Leonard WJ; Heise MT; Tedder TF. 2013. Regulatory B cell (B10 Cell) expansion during Listeria infection governs innate and cellular immune responses in mice. J Immunol 190(3):1158-68. [PubMed: 23275601]  [MGI Ref ID J:193035]

Hsu AC; Scott P. 2007. Leishmania mexicana infection induces impaired lymph node expansion and Th1 cell differentiation despite normal T cell proliferation. J Immunol 179(12):8200-7. [PubMed: 18056363]  [MGI Ref ID J:155036]

Hu S; Ciancio MJ; Lahav M; Fujiya M; Lichtenstein L; Anant S; Musch MW; Chang EB. 2007. Translational inhibition of colonic epithelial heat shock proteins by IFN-gamma and TNF-alpha in intestinal inflammation. Gastroenterology 133(6):1893-904. [PubMed: 18054561]  [MGI Ref ID J:135619]

Huang EH; Park JC; Appelman H; Weinberg AD; Banerjee M; Logsdon CD; Schmidt AM. 2006. Induction of inflammatory bowel disease accelerates adenoma formation in Min +/- mice. Surgery 139(6):782-8. [PubMed: 16782435]  [MGI Ref ID J:115828]

Huang G; Wang Y; Shi LZ; Kanneganti TD; Chi H. 2011. Signaling by the Phosphatase MKP-1 in Dendritic Cells Imprints Distinct Effector and Regulatory T Cell Fates. Immunity 35(1):45-58. [PubMed: 21723158]  [MGI Ref ID J:174378]

Huang H; Ostroff GR; Lee CK; Wang JP; Specht CA; Levitz SM. 2009. Distinct patterns of dendritic cell cytokine release stimulated by fungal beta-glucans and toll-like receptor agonists. Infect Immun 77(5):1774-81. [PubMed: 19273561]  [MGI Ref ID J:148181]

Hung CY; Castro-Lopez N; Cole GT. 2014. Vaccinated C57BL/6 mice develop protective and memory T cell responses to Coccidioides posadasii infection in the absence of interleukin-10. Infect Immun 82(2):903-13. [PubMed: 24478103]  [MGI Ref ID J:209804]

Hunter CA; Ellis-Neyes LA; Slifer T; Kanaly S; Grunig G; Fort M; Rennick D; Araujo FG. 1997. IL-10 is required to prevent immune hyperactivity during infection with Trypanosoma cruzi. J Immunol 158(7):3311-6. [PubMed: 9120288]  [MGI Ref ID J:110835]

Igietseme JU; Ananaba GA; Bolier J; Bowers S; Moore T; Belay T; Eko FO; Lyn D; Black CM. 2000. Suppression of endogenous IL-10 gene expression in dendritic cells enhances antigen presentation for specific Th1 induction: potential for cellular vaccine development. J Immunol 164(8):4212-9. [PubMed: 10754317]  [MGI Ref ID J:123433]

Ilarregui JM; Croci DO; Bianco GA; Toscano MA; Salatino M; Vermeulen ME; Geffner JR; Rabinovich GA. 2009. Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10. Nat Immunol 10(9):981-91. [PubMed: 19668220]  [MGI Ref ID J:151758]

Inoue S; Leitner WW; Golding B; Scott D. 2006. Inhibitory effects of B cells on antitumor immunity. Cancer Res 66(15):7741-7. [PubMed: 16885377]  [MGI Ref ID J:112103]

Ismail HF; Fick P; Zhang J; Lynch RG; Berg DJ. 2003. Depletion of neutrophils in IL-10(-/-) mice delays clearance of gastric Helicobacter infection and decreases the Th1 immune response to Helicobacter. J Immunol 170(7):3782-9. [PubMed: 12646644]  [MGI Ref ID J:125444]

Ismail HF; Zhang J; Lynch RG; Wang Y; Berg DJ. 2003. Role for complement in development of Helicobacter-induced gastritis in interleukin-10-deficient mice. Infect Immun 71(12):7140-8. [PubMed: 14638805]  [MGI Ref ID J:86649]

Ivanov SS; Roy CR. 2013. Pathogen signatures activate a ubiquitination pathway that modulates the function of the metabolic checkpoint kinase mTOR. Nat Immunol 14(12):1219-28. [PubMed: 24121838]  [MGI Ref ID J:208652]

Ivory CP; Wallace LE; McCafferty DM; Sigalet DL. 2008. Interleukin-10-independent anti-inflammatory actions of glucagon-like peptide 2. Am J Physiol Gastrointest Liver Physiol 295(6):G1202-10. [PubMed: 18845573]  [MGI Ref ID J:143407]

Jamontt J; Petit S; Clark N; Parkinson SJ; Smith P. 2013. Nucleotide-Binding Oligomerization Domain 2 Signaling Promotes Hyperresponsive Macrophages and Colitis in IL-10-Deficient Mice. J Immunol 190(6):2948-58. [PubMed: 23396949]  [MGI Ref ID J:193595]

Jankovic D; Kullberg MC; Feng CG; Goldszmid RS; Collazo CM; Wilson M; Wynn TA; Kamanaka M; Flavell RA; Sher A. 2007. Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection. J Exp Med 204(2):273-83. [PubMed: 17283209]  [MGI Ref ID J:125371]

Jankovic D; Kullberg MC; Hieny S; Caspar P; Collazo CM; Sher A. 2002. In the absence of IL-12, CD4(+) T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10(-/-) setting. Immunity 16(3):429-39. [PubMed: 11911827]  [MGI Ref ID J:113516]

Jeon SG; Kayama H; Ueda Y; Takahashi T; Asahara T; Tsuji H; Tsuji NM; Kiyono H; Ma JS; Kusu T; Okumura R; Hara H; Yoshida H; Yamamoto M; Nomoto K; Takeda K. 2012. Probiotic Bifidobacterium breve induces IL-10-producing Tr1 cells in the colon. PLoS Pathog 8(5):e1002714. [PubMed: 22693446]  [MGI Ref ID J:195381]

Jeyarajah DR; Kielar ML; Saboorian H; Karimi P; Frantz N; Lu CY. 2006. Impact of bile duct obstruction on hepatic E. coli infection: role of IL-10. Am J Physiol Gastrointest Liver Physiol 291(1):G91-4. [PubMed: 16769814]  [MGI Ref ID J:111075]

Jimenez Mdel P; Walls L; Fierer J. 2006. High levels of interleukin-10 impair resistance to pulmonary coccidioidomycosis in mice in part through control of nitric oxide synthase 2 expression. Infect Immun 74(6):3387-95. [PubMed: 16714569]  [MGI Ref ID J:109235]

Jin Y; Liu R; Xie J; Xiong H; He JC; Chen N. 2013. Interleukin-10 deficiency aggravates kidney inflammation and fibrosis in the unilateral ureteral obstruction mouse model. Lab Invest 93(7):801-11. [PubMed: 23628901]  [MGI Ref ID J:198752]

Joffre O; Santolaria T; Calise D; Al Saati T; Hudrisier D; Romagnoli P; van Meerwijk JP. 2008. Prevention of acute and chronic allograft rejection with CD4+CD25+Foxp3+ regulatory T lymphocytes. Nat Med 14(1):88-92. [PubMed: 18066074]  [MGI Ref ID J:130486]

Johansson AC; Hansson AS; Nandakumar KS; Backlund J; Holmdahl R. 2001. Il-10-deficient b10.q mice develop more severe collagen-induced arthritis, but are protected from arthritis induced with anti-type ii collagen antibodies. J Immunol 167(6):3505-12. [PubMed: 11544344]  [MGI Ref ID J:71518]

Joller N; Lozano E; Burkett PR; Patel B; Xiao S; Zhu C; Xia J; Tan TG; Sefik E; Yajnik V; Sharpe AH; Quintana FJ; Mathis D; Benoist C; Hafler DA; Kuchroo VK. 2014. Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses. Immunity 40(4):569-81. [PubMed: 24745333]  [MGI Ref ID J:209951]

Jones DE; Ackermann MR; Wille U; Hunter CA; Scott P. 2002. Early enhanced Th1 response after Leishmania amazonensis infection of C57BL/6 interleukin-10-deficient mice does not lead to resolution of infection. Infect Immun 70(4):2151-8. [PubMed: 11895981]  [MGI Ref ID J:75483]

Jones SP; Trocha SD; Lefer DJ. 2001. Cardioprotective actions of endogenous IL-10 are independent of iNOS. Am J Physiol Heart Circ Physiol 281(1):H48-52. [PubMed: 11406467]  [MGI Ref ID J:70292]

Jones TG; Finkelman FD; Austen KF; Gurish MF. 2010. T regulatory cells control antigen-induced recruitment of mast cell progenitors to the lungs of C57BL/6 mice. J Immunol 185(3):1804-11. [PubMed: 20601599]  [MGI Ref ID J:162451]

Joo YE; Karrasch T; Muhlbauer M; Allard B; Narula A; Herfarth HH; Jobin C. 2009. Tomato lycopene extract prevents lipopolysaccharide-induced NF-kappaB signaling but worsens dextran sulfate sodium-induced colitis in NF-kappaBEGFP mice. PLoS ONE 4(2):e4562. [PubMed: 19234608]  [MGI Ref ID J:146226]

Jung YJ; Ryan L; LaCourse R; North RJ. 2003. Increased interleukin-10 expression is not responsible for failure of T helper 1 immunity to resolve airborne Mycobacterium tuberculosis infection in mice. Immunology 109(2):295-9. [PubMed: 12757625]  [MGI Ref ID J:83724]

Jurisic G; Sundberg JP; Bleich A; Leiter EH; Broman KW; Buechler G; Alley L; Vestweber D; Detmar M. 2010. Quantitative lymphatic vessel trait analysis suggests Vcam1 as candidate modifier gene of inflammatory bowel disease. Genes Immun 11(3):219-31. [PubMed: 20220769]  [MGI Ref ID J:159522]

Justice JP; Shibata Y; Sur S; Mustafa J; Fan M; Van Scott MR. 2001. IL-10 gene knockout attenuates allergen-induced airway hyperresponsiveness in C57BL/6 mice. Am J Physiol Lung Cell Mol Physiol 280(2):L363-8. [PubMed: 11159016]  [MGI Ref ID J:68061]

Kabbur PM; Carson WF 4th; Guernsey L; Secor ER Jr; Thrall RS; Schramm CM. 2006. Interleukin-10 does not mediate inhalational tolerance in a chronic model of ovalbumin-induced allergic airway disease. Cell Immunol 239(1):67-74. [PubMed: 16765924]  [MGI Ref ID J:110165]

Kadayakkara DK; Ranganathan S; Young WB; Ahrens ET. 2012. Assaying macrophage activity in a murine model of inflammatory bowel disease using fluorine-19 MRI. Lab Invest 92(4):636-45. [PubMed: 22330343]  [MGI Ref ID J:181905]

Kaiser F; Cook D; Papoutsopoulou S; Rajsbaum R; Wu X; Yang HT; Grant S; Ricciardi-Castagnoli P; Tsichlis PN; Ley SC; O'Garra A. 2009. TPL-2 negatively regulates interferon-beta production in macrophages and myeloid dendritic cells. J Exp Med 206(9):1863-71. [PubMed: 19667062]  [MGI Ref ID J:152170]

Kalkunte SS; Neubeck S; Norris WE; Cheng SB; Kostadinov S; Vu Hoang D; Ahmed A; von Eggeling F; Shaikh Z; Padbury J; Berg G; Olofsson A; Markert UR; Sharma S. 2013. Transthyretin is dysregulated in preeclampsia, and its native form prevents the onset of disease in a preclinical mouse model. Am J Pathol 183(5):1425-36. [PubMed: 24035612]  [MGI Ref ID J:202475]

Kamada N; Hisamatsu T; Okamoto S; Sato T; Matsuoka K; Arai K; Nakai T; Hasegawa A; Inoue N; Watanabe N; Akagawa KS; Hibi T. 2005. Abnormally differentiated subsets of intestinal macrophage play a key role in Th1-dominant chronic colitis through excess production of IL-12 and IL-23 in response to bacteria. J Immunol 175(10):6900-8. [PubMed: 16272349]  [MGI Ref ID J:119692]

Kamanaka M; Huber S; Zenewicz LA; Gagliani N; Rathinam C; O'Connor W Jr; Wan YY; Nakae S; Iwakura Y; Hao L; Flavell RA. 2011. Memory/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology. J Exp Med 208(5):1027-40. [PubMed: 21518800]  [MGI Ref ID J:177300]

Kanazawa Y; Saito Y; Supriatna Y; Tezuka H; Kotani T; Murata Y; Okazawa H; Ohnishi H; Kinouchi Y; Nojima Y; Ohteki T; Shimosegawa T; Matozaki T. 2010. Role of SIRPalpha in regulation of mucosal immunity in the intestine. Genes Cells 15(12):1189-200. [PubMed: 21040253]  [MGI Ref ID J:186324]

Kane MM; Mosser DM. 2001. The role of IL-10 in promoting disease progression in leishmaniasis. J Immunol 166(2):1141-7. [PubMed: 11145695]  [MGI Ref ID J:66849]

Kapp JA; Honjo K; Kapp LM; Xu X; Cozier A; Bucy RP. 2006. TCR transgenic CD8+ T cells activated in the presence of TGFbeta express FoxP3 and mediate linked suppression of primary immune responses and cardiac allograft rejection. Int Immunol 18(11):1549-62. [PubMed: 16966495]  [MGI Ref ID J:114951]

Karrasch T; Kim JS; Jang BI; Jobin C. 2007. The flavonoid luteolin worsens chemical-induced colitis in NF-kappaB(EGFP) transgenic mice through blockade of NF-kappaB-dependent protective molecules. PLoS ONE 2(7):e596. [PubMed: 17611628]  [MGI Ref ID J:129302]

Karrasch T; Kim JS; Muhlbauer M; Magness ST; Jobin C. 2007. Gnotobiotic IL-10-/-;NF-kappa B(EGFP) mice reveal the critical role of TLR/NF-kappa B signaling in commensal bacteria-induced colitis. J Immunol 178(10):6522-32. [PubMed: 17475882]  [MGI Ref ID J:146107]

Kastenmuller W; Gasteiger G; Subramanian N; Sparwasser T; Busch DH; Belkaid Y; Drexler I; Germain RN. 2011. Regulatory T cells selectively control CD8+ T cell effector pool size via IL-2 restriction. J Immunol 187(6):3186-97. [PubMed: 21849683]  [MGI Ref ID J:179230]

Kato A; Okaya T; Lentsch AB. 2003. Endogenous IL-13 protects hepatocytes and vascular endothelial cells during ischemia/reperfusion injury. Hepatology 37(2):304-12. [PubMed: 12540780]  [MGI Ref ID J:105813]

Kawachi S; Jennings S; Panes J; Cockrell A; Laroux FS; Gray L; Perry M; van der Heyde H; Balish E; Granger DN; Specian RA; Grisham MB. 2000. Cytokine and endothelial cell adhesion molecule expression in interleukin-10-deficient mice. Am J Physiol Gastrointest Liver Physiol 278(5):G734-43. [PubMed: 10801266]  [MGI Ref ID J:108662]

Kearley J; Barker JE; Robinson DS; Lloyd CM. 2005. Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4+CD25+ regulatory T cells is interleukin 10 dependent. J Exp Med 202(11):1539-47. [PubMed: 16314435]  [MGI Ref ID J:118855]

Kellermann SA; McEvoy LM. 2001. The Peyer's patch microenvironment suppresses T cell responses to chemokines and other stimuli. J Immunol 167(2):682-90. [PubMed: 11441071]  [MGI Ref ID J:120507]

Kelly J; Ali Khan A; Yin J; Ferguson TA; Apte RS. 2007. Senescence regulates macrophage activation and angiogenic fate at sites of tissue injury in mice. J Clin Invest 117(11):3421-6. [PubMed: 17975672]  [MGI Ref ID J:127374]

Kim SC; Tonkonogy SL; Albright CA; Tsang J; Balish EJ; Braun J; Huycke MM; Sartor RB. 2005. Variable phenotypes of enterocolitis in interleukin 10-deficient mice monoassociated with two different commensal bacteria. Gastroenterology 128(4):891-906. [PubMed: 15825073]  [MGI Ref ID J:97309]

Kimura T; Sugaya M; Blauvelt A; Okochi H; Sato S. 2013. Delayed wound healing due to increased interleukin-10 expression in mice with lymphatic dysfunction. J Leukoc Biol 94(1):137-45. [PubMed: 23650621]  [MGI Ref ID J:201849]

Kinnebrew MA; Buffie CG; Diehl GE; Zenewicz LA; Leiner I; Hohl TM; Flavell RA; Littman DR; Pamer EG. 2012. Interleukin 23 Production by Intestinal CD103(+)CD11b(+) Dendritic Cells in Response to Bacterial Flagellin Enhances Mucosal Innate Immune Defense. Immunity 36(2):276-87. [PubMed: 22306017]  [MGI Ref ID J:181332]

Kish L; Hotte N; Kaplan GG; Vincent R; Tso R; Ganzle M; Rioux KP; Thiesen A; Barkema HW; Wine E; Madsen KL. 2013. Environmental particulate matter induces murine intestinal inflammatory responses and alters the gut microbiome. PLoS One 8(4):e62220. [PubMed: 23638009]  [MGI Ref ID J:200552]

Kitamura H; Yamamoto S; Nakase H; Matsuura M; Honzawa Y; Matsumura K; Takeda Y; Uza N; Nagata K; Chiba T. 2011. Role of heat shock protein 47 in intestinal fibrosis of experimental colitis. Biochem Biophys Res Commun 404(2):599-604. [PubMed: 21144841]  [MGI Ref ID J:168792]

Kobayashi T; Steinbach EC; Russo SM; Matsuoka K; Nochi T; Maharshak N; Borst LB; Hostager B; Garcia-Martinez JV; Rothman PB; Kashiwada M; Sheikh SZ; Murray PJ; Plevy SE. 2014. NFIL3-deficient mice develop microbiota-dependent, IL-12/23-driven spontaneous colitis. J Immunol 192(4):1918-27. [PubMed: 24442434]  [MGI Ref ID J:209365]

Kontoyiannis D; Kotlyarov A; Carballo E; Alexopoulou L; Blackshear PJ; Gaestel M; Davis R; Flavell R; Kollias G. 2001. Interleukin-10 targets p38 MAPK to modulate ARE-dependent TNF mRNA translation and limit intestinal pathology. EMBO J 20(14):3760-70. [PubMed: 11447117]  [MGI Ref ID J:108402]

Kosiewicz MM; Alard P; Liang S; Clark SL. 2004. Mechanisms of tolerance induced by transforming growth factor-beta-treated antigen-presenting cells: CD8 regulatory T cells inhibit the effector phase of the immune response in primed mice through a mechanism involving Fas ligand. Int Immunol 16(5):697-706. [PubMed: 15096489]  [MGI Ref ID J:89454]

Kowalski GM; Nicholls HT; Risis S; Watson NK; Kanellakis P; Bruce CR; Bobik A; Lancaster GI; Febbraio MA. 2011. Deficiency of haematopoietic-cell-derived IL-10 does not exacerbate high-fat-diet-induced inflammation or insulin resistance in mice. Diabetologia :. [PubMed: 21210076]  [MGI Ref ID J:168585]

Kraus TA; Brimnes J; Muong C; Liu JH; Moran TM; Tappenden KA; Boros P; Mayer L. 2005. Induction of mucosal tolerance in Peyer's patch-deficient, ligated small bowel loops. J Clin Invest 115(8):2234-2243. [PubMed: 16041410]  [MGI Ref ID J:100225]

Krishnamurthy P; Lambers E; Verma S; Thorne T; Qin G; Losordo DW; Kishore R. 2010. Myocardial knockdown of mRNA-stabilizing protein HuR attenuates post-MI inflammatory response and left ventricular dysfunction in IL-10-null mice. FASEB J 24(7):2484-94. [PubMed: 20219984]  [MGI Ref ID J:162353]

Krishnamurthy P; Thal M; Verma S; Hoxha E; Lambers E; Ramirez V; Qin G; Losordo D; Kishore R. 2011. Interleukin-10 deficiency impairs bone marrow-derived endothelial progenitor cell survival and function in ischemic myocardium. Circ Res 109(11):1280-9. [PubMed: 21959218]  [MGI Ref ID J:188819]

Kryczek I; Wei S; Zou L; Zhu G; Mottram P; Xu H; Chen L; Zou W. 2006. Cutting edge: induction of B7-H4 on APCs through IL-10: novel suppressive mode for regulatory T cells. J Immunol 177(1):40-4. [PubMed: 16785496]  [MGI Ref ID J:134411]

Krzyszton CP; Sparkman NL; Grant RW; Buchanan JB; Broussard SR; Woods J; Johnson RW. 2008. Exacerbated fatigue and motor deficits in interleukin-10-deficient mice after peripheral immune stimulation. Am J Physiol Regul Integr Comp Physiol 295(4):R1109-14. [PubMed: 18650318]  [MGI Ref ID J:139972]

Kuhn R; Lohler J; Rennick D; Rajewsky K; Muller W. 1993. Interleukin-10-deficient mice develop chronic enterocolitis [see comments] Cell 75(2):263-74. [PubMed: 8402911]  [MGI Ref ID J:15222]

Kulcsar KA; Baxter VK; Greene IP; Griffin DE. 2014. Interleukin 10 modulation of pathogenic Th17 cells during fatal alphavirus encephalomyelitis. Proc Natl Acad Sci U S A 111(45):16053-8. [PubMed: 25362048]  [MGI Ref ID J:216759]

Kuo SM; Merhige PM; Hagey LR. 2013. The effect of dietary prebiotics and probiotics on body weight, large intestine indices, and fecal bile acid profile in wild type and IL10-/- mice. PLoS One 8(3):e60270. [PubMed: 23555939]  [MGI Ref ID J:199881]

Kurakevich E; Hennet T; Hausmann M; Rogler G; Borsig L. 2013. Milk oligosaccharide sialyl(alpha2,3)lactose activates intestinal CD11c+ cells through TLR4. Proc Natl Acad Sci U S A 110(43):17444-9. [PubMed: 24101501]  [MGI Ref ID J:201973]

Kurkjian C; Hollifield M; Lines JL; Rogosky A; Empey KM; Qureshi M; Brown SA; Garvy BA. 2012. Alveolar Macrophages in Neonatal Mice Are Inherently Unresponsive to Pneumocystis murina Infection. Infect Immun 80(8):2835-46. [PubMed: 22665378]  [MGI Ref ID J:186637]

Kuwata H; Watanabe Y; Miyoshi H; Yamamoto M; Kaisho T; Takeda K; Akira S. 2003. IL-10-inducible Bcl-3 negatively regulates LPS-induced TNF-alpha production in macrophages. Blood 102(12):4123-9. [PubMed: 12907458]  [MGI Ref ID J:86681]

Lampropoulou V; Hoehlig K; Roch T; Neves P; Gomez EC; Sweenie CH; Hao Y; Freitas AA; Steinhoff U; Anderton SM; Fillatreau S. 2008. TLR-Activated B Cells Suppress T Cell-Mediated Autoimmunity. J Immunol 180(7):4763-73. [PubMed: 18354200]  [MGI Ref ID J:133381]

Larson D; Hubner MP; Torrero MN; Morris CP; Brankin A; Swierczewski BE; Davies SJ; Vonakis BM; Mitre E. 2012. Chronic helminth infection reduces basophil responsiveness in an IL-10-dependent manner. J Immunol 188(9):4188-99. [PubMed: 22461700]  [MGI Ref ID J:188452]

Lathrop SK; Bloom SM; Rao SM; Nutsch K; Lio CW; Santacruz N; Peterson DA; Stappenbeck TS; Hsieh CS. 2011. Peripheral education of the immune system by colonic commensal microbiota. Nature 478(7368):250-4. [PubMed: 21937990]  [MGI Ref ID J:177128]

Lazarus JJ; Kay MA; McCarter AL; Wooten RM. 2008. Viable Borrelia burgdorferi enhances interleukin-10 production and suppresses activation of murine macrophages. Infect Immun 76(3):1153-62. [PubMed: 18086805]  [MGI Ref ID J:131640]

Lazarus JJ; Meadows MJ; Lintner RE; Wooten RM. 2006. IL-10 deficiency promotes increased Borrelia burgdorferi clearance predominantly through enhanced innate immune responses. J Immunol 177(10):7076-85. [PubMed: 17082624]  [MGI Ref ID J:140484]

Lee CC; Kung JT. 2012. Marginal zone B cell is a major source of Il-10 in Listeria monocytogenes susceptibility. J Immunol 189(7):3319-27. [PubMed: 22933629]  [MGI Ref ID J:190348]

Lee CG; Homer RJ; Cohn L; Link H; Jung S; Craft JE; Graham BS; Johnson TR; Elias JA. 2002. Transgenic overexpression of interleukin (IL)-10 in the lung causes mucus metaplasia, tissue inflammation, and airway remodeling via IL-13-dependent and -independent pathways. J Biol Chem 277(38):35466-74. [PubMed: 12107190]  [MGI Ref ID J:79116]

Lee CW; Rao VP; Rogers AB; Ge Z; Erdman SE; Whary MT; Fox JG. 2007. Wild-type and interleukin-10-deficient regulatory T cells reduce effector T-cell-mediated gastroduodenitis in Rag2-/- mice, but only wild-type regulatory T cells suppress Helicobacter pylori gastritis. Infect Immun 75(6):2699-707. [PubMed: 17353283]  [MGI Ref ID J:121929]

Lee JH; Lee GT; Woo SH; Ha YS; Kwon SJ; Kim WJ; Kim IY. 2013. BMP-6 in renal cell carcinoma promotes tumor proliferation through IL-10-dependent M2 polarization of tumor-associated macrophages. Cancer Res 73(12):3604-14. [PubMed: 23633487]  [MGI Ref ID J:199016]

Lenzen H; Lunnemann M; Bleich A; Manns MP; Seidler U; Jorns A. 2012. Downregulation of the NHE3-binding PDZ-adaptor protein PDZK1 expression during cytokine-induced inflammation in interleukin-10-deficient mice. PLoS One 7(7):e40657. [PubMed: 22848392]  [MGI Ref ID J:189711]

Leveson-Gower DB; Sega EI; Kalesnikoff J; Florek M; Pan Y; Pierini A; Galli SJ; Negrin RS. 2013. Mast cells suppress murine GVHD in a mechanism independent of CD4+CD25+ regulatory T cells. Blood 122(22):3659-65. [PubMed: 24030387]  [MGI Ref ID J:204074]

Li C; Corraliza I; Langhorne J. 1999. A defect in interleukin-10 leads to enhanced malarial disease in Plasmodium chabaudi chabaudi infection in mice. Infect Immun 67(9):4435-42. [PubMed: 10456884]  [MGI Ref ID J:57118]

Li Y; Yu C; Zhu WM; Xie Y; Qi X; Li N; Li JS. 2010. Triptolide ameliorates IL-10-deficient mice colitis by mechanisms involving suppression of IL-6/STAT3 signaling pathway and down-regulation of IL-17. Mol Immunol 47(15):2467-74. [PubMed: 20615550]  [MGI Ref ID J:163936]

Lin KL; Fulton LM; Berginski M; West ML; Taylor NA; Moran TP; Coghill JM; Blazar BR; Bear JE; Serody JS. 2014. Intravital imaging of donor allogeneic effector and regulatory T cells with host dendritic cells during GVHD. Blood 123(10):1604-14. [PubMed: 24415540]  [MGI Ref ID J:209503]

Lippert E; Karrasch T; Sun X; Allard B; Herfarth HH; Threadgill D; Jobin C. 2009. Gnotobiotic IL-10; NF-kappaB mice develop rapid and severe colitis following Campylobacter jejuni infection. PLoS One 4(10):e7413. [PubMed: 19841748]  [MGI Ref ID J:154043]

Liu Y; Bi X; Xu S; Xiang J. 2005. Tumor-infiltrating dendritic cell subsets of progressive or regressive tumors induce suppressive or protective immune responses. Cancer Res 65(11):4955-62. [PubMed: 15930318]  [MGI Ref ID J:98765]

Liu Z; Falo LD Jr; You Z. 2011. Knockdown of HMGB1 in tumor cells attenuates their ability to induce regulatory T cells and uncovers naturally acquired CD8 T cell-dependent antitumor immunity. J Immunol 187(1):118-25. [PubMed: 21642542]  [MGI Ref ID J:176186]

Liu Z; Liu JQ; Talebian F; Wu LC; Li S; Bai XF. 2013. IL-27 enhances the survival of tumor antigen-specific CD8(+) T cells and programs them into IL-10-producing, memory precursor-like effector cells. Eur J Immunol 43(2):468-79. [PubMed: 23225163]  [MGI Ref ID J:193049]

Liva SM; Voskuhl RR. 2001. Testosterone acts directly on CD4+ T lymphocytes to increase IL-10 production. J Immunol 167(4):2060-7. [PubMed: 11489988]  [MGI Ref ID J:120413]

London A; Itskovich E; Benhar I; Kalchenko V; Mack M; Jung S; Schwartz M. 2011. Neuroprotection and progenitor cell renewal in the injured adult murine retina requires healing monocyte-derived macrophages. J Exp Med 208(1):23-39. [PubMed: 21220455]  [MGI Ref ID J:176855]

Londono D; Marques A; Hornung RL; Cadavid D. 2008. IL-10 helps control pathogen load during high-level bacteremia. J Immunol 181(3):2076-83. [PubMed: 18641346]  [MGI Ref ID J:139233]

Londono D; Marques A; Hornung RL; Cadavid D. 2008. Relapsing fever borreliosis in interleukin-10-deficient mice. Infect Immun 76(12):5508-13. [PubMed: 18794280]  [MGI Ref ID J:142597]

Loser K; Apelt J; Voskort M; Mohaupt M; Balkow S; Schwarz T; Grabbe S; Beissert S. 2007. IL-10 controls ultraviolet-induced carcinogenesis in mice. J Immunol 179(1):365-71. [PubMed: 17579057]  [MGI Ref ID J:125760]

Louis H; Van Laethem JL; Wu W; Quertinmont E; Degraef C; Van den Berg K; Demols A; Goldman M; Le Moine O; Geerts A; Deviere J. 1998. Interleukin-10 controls neutrophilic infiltration, hepatocyte proliferation, and liver fibrosis induced by carbon tetrachloride in mice. Hepatology 28(6):1607-15. [PubMed: 9828225]  [MGI Ref ID J:106536]

Lu L; Ma J; Wang X; Wang J; Zhang F; Yu J; He G; Xu B; Brand DD; Horwitz DA; Shi W; Zheng SG. 2010. Synergistic effect of TGF-beta superfamily members on the induction of Foxp3+ Treg. Eur J Immunol 40(1):142-52. [PubMed: 19943263]  [MGI Ref ID J:155683]

Luan B; Goodarzi MO; Phillips NG; Guo X; Chen YD; Yao J; Allison M; Rotter JI; Shaw R; Montminy M. 2014. Leptin-mediated increases in catecholamine signaling reduce adipose tissue inflammation via activation of macrophage HDAC4. Cell Metab 19(6):1058-65. [PubMed: 24768298]  [MGI Ref ID J:215277]

Ly LH; Smith R rd; Chapkin RS; McMurray DN. 2005. Dietary n-3 polyunsaturated fatty acids suppress splenic CD4(+) T cell function in interleukin (IL)-10(-/-) mice. Clin Exp Immunol 139(2):202-9. [PubMed: 15654818]  [MGI Ref ID J:105106]

Lytle C; Tod TJ; Vo KT; Lee JW; Atkinson RD; Straus DS. 2005. The Peroxisome Proliferator-Activated Receptor gamma Ligand Rosiglitazone Delays the Onset of Inflammatory Bowel Disease in Mice with Interleukin 10 Deficiency. Inflamm Bowel Dis 11(3):231-43. [PubMed: 15735429]  [MGI Ref ID J:97868]

MacKenzie KF; Van Den Bosch MW; Naqvi S; Elcombe SE; McGuire VA; Reith AD; Blackshear PJ; Dean JL; Arthur JS. 2013. MSK1 and MSK2 inhibit lipopolysaccharide-induced prostaglandin production via an interleukin-10 feedback loop. Mol Cell Biol 33(7):1456-67. [PubMed: 23382072]  [MGI Ref ID J:203325]

Machado FS; Esper L; Dias A; Madan R; Gu Y; Hildeman D; Serhan CN; Karp CL; Aliberti J. 2008. Native and aspirin-triggered lipoxins control innate immunity by inducing proteasomal degradation of TRAF6. J Exp Med 205(5):1077-86. [PubMed: 18411340]  [MGI Ref ID J:136277]

Mackenzie KF; Clark K; Naqvi S; McGuire VA; Noehren G; Kristariyanto Y; van den Bosch M; Mudaliar M; McCarthy PC; Pattison MJ; Pedrioli PG; Barton GJ; Toth R; Prescott A; Arthur JS. 2013. PGE2 Induces Macrophage IL-10 Production and a Regulatory-like Phenotype via a Protein Kinase A-SIK-CRTC3 Pathway. J Immunol 190(2):565-77. [PubMed: 23241891]  [MGI Ref ID J:191723]

Madala SK; Pesce JT; Ramalingam TR; Wilson MS; Minnicozzi S; Cheever AW; Thompson RW; Mentink-Kane MM; Wynn TA. 2010. Matrix metalloproteinase 12-deficiency augments extracellular matrix degrading metalloproteinases and attenuates IL-13-dependent fibrosis. J Immunol 184(7):3955-63. [PubMed: 20181883]  [MGI Ref ID J:160097]

Madsen KL; Doyle JS; Jewell LD; Tavernini MM; Fedorak RN. 1999. Lactobacillus species prevents colitis in interleukin 10 gene-deficient mice. Gastroenterology 116(5):1107-14. [PubMed: 10220502]  [MGI Ref ID J:106688]

Madsen KL; Doyle JS; Tavernini MM; Jewell LD; Rennie RP; Fedorak RN. 2000. Antibiotic therapy attenuates colitis in interleukin 10 gene-deficient mice. Gastroenterology 118(6):1094-105. [PubMed: 10833484]  [MGI Ref ID J:107748]

Madsen KL; Malfair D; Gray D; Doyle JS; Jewell LD; Fedorak RN. 1999. Interleukin-10 gene-deficient mice develop a primary intestinal permeability defect in response to enteric microflora. Inflamm Bowel Dis 5(4):262-70. [PubMed: 10579119]  [MGI Ref ID J:59872]

Madureira P; Baptista M; Vieira M; Magalhaes V; Camelo A; Oliveira L; Ribeiro A; Tavares D; Trieu-Cuot P; Vilanova M; Ferreira P. 2007. Streptococcus agalactiae GAPDH is a virulence-associated immunomodulatory protein. J Immunol 178(3):1379-87. [PubMed: 17237385]  [MGI Ref ID J:143659]

Maeda A; Beissert S; Schwarz T; Schwarz A. 2008. Phenotypic and functional characterization of ultraviolet radiation-induced regulatory T cells. J Immunol 180(5):3065-71. [PubMed: 18292529]  [MGI Ref ID J:131531]

Mahler M; Most C; Schmidtke S; Sundberg J; Li R; Hedrich H; Churchill G. 2002. Genetics of Colitis Susceptibility in IL-10-Deficient Mice: Backcross versus F2 Results Contrasted by Principal Component Analysis. Genomics 80(3):274. [PubMed: 12213197]  [MGI Ref ID J:78917]

Makela MJ; Kanehiro A; Borish L; Dakhama A; Loader J; Joetham A; Xing Z; Jordana M; Larsen GL; Gelfand EW. 2000. IL-10 is necessary for the expression of airway hyperresponsiveness but not pulmonary inflammation after allergic sensitization. Proc Natl Acad Sci U S A 97(11):6007-12. [PubMed: 10811896]  [MGI Ref ID J:62283]

Mane J; Pedrosa E; Loren V; Ojanguren I; Fluvia L; Cabre E; Rogler G; Gassull MA. 2009. Partial replacement of dietary (n-6) fatty acids with medium-chain triglycerides decreases the incidence of spontaneous colitis in interleukin-10-deficient mice. J Nutr 139(3):603-10. [PubMed: 19126671]  [MGI Ref ID J:145707]

Manicassamy S; Ravindran R; Deng J; Oluoch H; Denning TL; Kasturi SP; Rosenthal KM; Evavold BD; Pulendran B. 2009. Toll-like receptor 2-dependent induction of vitamin A-metabolizing enzymes in dendritic cells promotes T regulatory responses and inhibits autoimmunity. Nat Med 15(4):401-9. [PubMed: 19252500]  [MGI Ref ID J:149376]

Mansfield LS; Bell JA; Wilson DL; Murphy AJ; Elsheikha HM; Rathinam VA; Fierro BR; Linz JE; Young VB. 2007. C57BL/6 and Congenic Interleukin-10-Deficient Mice Can Serve as Models of Campylobacter jejuni Colonization and Enteritis. Infect Immun 75(3):1099-115. [PubMed: 17130251]  [MGI Ref ID J:118502]

Martin ME; Caspersen K; Dumler JS. 2001. Immunopathology and ehrlichial propagation are regulated by interferon-gamma and interleukin-10 in a murine model of human granulocytic ehrlichiosis. Am J Pathol 158(5):1881-8. [PubMed: 11337387]  [MGI Ref ID J:69104]

Mascanfroni ID; Yeste A; Vieira SM; Burns EJ; Patel B; Sloma I; Wu Y; Mayo L; Ben-Hamo R; Efroni S; Kuchroo VK; Robson SC; Quintana FJ. 2013. IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39. Nat Immunol 14(10):1054-63. [PubMed: 23995234]  [MGI Ref ID J:208218]

Maseda D; Candando KM; Smith SH; Kalampokis I; Weaver CT; Plevy SE; Poe JC; Tedder TF. 2013. Peritoneal cavity regulatory B cells (B10 cells) modulate IFN-gamma+CD4+ T cell numbers during colitis development in mice. J Immunol 191(5):2780-95. [PubMed: 23918988]  [MGI Ref ID J:205795]

Masso-Welch PA; Merhige PM; Veeranki OL; Kuo SM. 2012. Loss of IL-10 decreases mouse postpubertal mammary gland development in the absence of inflammation. Immunol Invest 41(5):521-37. [PubMed: 22594921]  [MGI Ref ID J:201573]

Matlack R; Yeh K; Rosini L; Gonzalez D; Taylor J; Silberman D; Pennello A; Riggs J. 2006. Peritoneal macrophages suppress T-cell activation by amino acid catabolism. Immunology 117(3):386-95. [PubMed: 16476058]  [MGI Ref ID J:107076]

Matsumura Y; Byrne SN; Nghiem DX; Miyahara Y; Ullrich SE. 2006. A role for inflammatory mediators in the induction of immunoregulatory B cells. J Immunol 177(7):4810-7. [PubMed: 16982922]  [MGI Ref ID J:139306]

Matsushita T; Horikawa M; Iwata Y; Tedder TF. 2010. Regulatory B cells (b10 cells) and regulatory T cells have independent roles in controlling experimental autoimmune encephalomyelitis initiation and late-phase immunopathogenesis. J Immunol 185(4):2240-52. [PubMed: 20624940]  [MGI Ref ID J:162387]

Matta R; Barnard JA; Wancket LM; Yan J; Xue J; Grieves J; Frazier WJ; Nelin L; Cato AC; Liu Y. 2012. Knockout of Mkp-1 exacerbates colitis in Il-10-deficient mice. Am J Physiol Gastrointest Liver Physiol 302(11):G1322-35. [PubMed: 22461024]  [MGI Ref ID J:191160]

Maurer M; Seidel-Guyenot W; Metz M; Knop J; Steinbrink K. 2003. Critical role of IL-10 in the induction of low zone tolerance to contact allergens. J Clin Invest 112(3):432-9. [PubMed: 12865418]  [MGI Ref ID J:118509]

Mayer-Barber KD; Andrade BB; Oland SD; Amaral EP; Barber DL; Gonzales J; Derrick SC; Shi R; Kumar NP; Wei W; Yuan X; Zhang G; Cai Y; Babu S; Catalfamo M; Salazar AM; Via LE; Barry CE 3rd; Sher A. 2014. Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk. Nature 511(7507):99-103. [PubMed: 24990750]  [MGI Ref ID J:213640]

Maynard CL; Harrington LE; Janowski KM; Oliver JR; Zindl CL; Rudensky AY; Weaver CT. 2007. Regulatory T cells expressing interleukin 10 develop from Foxp3(+) and Foxp3(-) precursor cells in the absence of interleukin 10. Nat Immunol 8(9):931-41. [PubMed: 17694059]  [MGI Ref ID J:124255]

McBride S; Hoebe K; Georgel P; Janssen E. 2006. Cell-associated double-stranded RNA enhances antitumor activity through the production of type I IFN. J Immunol 177(9):6122-8. [PubMed: 17056539]  [MGI Ref ID J:140522]

McCafferty DM; Sihota E; Muscara M; Wallace JL; Sharkey KA; Kubes P. 2000. Spontaneously developing chronic colitis in IL-10/iNOS double-deficient mice. Am J Physiol Gastrointest Liver Physiol 279(1):G90-9. [PubMed: 10898750]  [MGI Ref ID J:107861]

McDole JR; Wheeler LW; McDonald KG; Wang B; Konjufca V; Knoop KA; Newberry RD; Miller MJ. 2012. Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine. Nature 483(7389):345-9. [PubMed: 22422267]  [MGI Ref ID J:182576]

McGeachy MJ; Bak-Jensen KS; Chen Y; Tato CM; Blumenschein W; McClanahan T; Cua DJ. 2007. TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology. Nat Immunol 8(12):1390-7. [PubMed: 17994024]  [MGI Ref ID J:127772]

McPhee JB; Mena P; Zhang Y; Bliska JB. 2012. Interleukin-10 induction is an important virulence function of the Yersinia pseudotuberculosis type III effector YopM. Infect Immun 80(7):2519-27. [PubMed: 22547545]  [MGI Ref ID J:186677]

Mencacci A; Montagnoli C; Bacci A; Cenci E; Pitzurra L; Spreca A; Kopf M; Sharpe AH; Romani L. 2002. CD80+Gr-1+ myeloid cells inhibit development of antifungal Th1 immunity in mice with candidiasis. J Immunol 169(6):3180-90. [PubMed: 12218136]  [MGI Ref ID J:120204]

Menezes GB; Lee WY; Zhou H; Waterhouse CC; Cara DC; Kubes P. 2009. Selective down-regulation of neutrophil Mac-1 in endotoxemic hepatic microcirculation via IL-10. J Immunol 183(11):7557-68. [PubMed: 19917697]  [MGI Ref ID J:157512]

Mesples B; Plaisant F; Gressens P. 2003. Effects of interleukin-10 on neonatal excitotoxic brain lesions in mice. Brain Res Dev Brain Res 141(1-2):25-32. [PubMed: 12644245]  [MGI Ref ID J:82655]

Metzger DW; Salmon SL; Kirimanjeswara G. 2013. Differing effects of interleukin-10 on cutaneous and pulmonary Francisella tularensis live vaccine strain infection. Infect Immun 81(6):2022-7. [PubMed: 23529615]  [MGI Ref ID J:199533]

Minami M; Shimizu K; Okamoto Y; Folco E; Ilasaca ML; Feinberg MW; Aikawa M; Libby P. 2008. Prostaglandin E receptor type 4-associated protein interacts directly with NF-kappaB1 and attenuates macrophage activation. J Biol Chem 283(15):9692-703. [PubMed: 18270204]  [MGI Ref ID J:135247]

Mittal R; Gonzalez-Gomez I; Panigrahy A; Goth K; Bonnet R; Prasadarao NV. 2010. IL-10 administration reduces PGE-2 levels and promotes CR3-mediated clearance of Escherichia coli K1 by phagocytes in meningitis. J Exp Med 207(6):1307-19. [PubMed: 20498022]  [MGI Ref ID J:163420]

Mizoguchi A; Mizoguchi E; Takedatsu H; Blumberg RS; Bhan AK. 2002. Chronic Intestinal Inflammatory Condition Generates IL-10-Producing Regulatory B Cell Subset Characterized by CD1d Upregulation. Immunity 16(2):219-30. [PubMed: 11869683]  [MGI Ref ID J:74718]

Mizushima T; Arakawa S; Sanada Y; Yoshino I; Miyazaki D; Urushima H; Tsujimoto Y; Ito T; Shimizu S. 2013. Inhibition of epithelial cell death by Bcl-2 improved chronic colitis in IL-10 KO mice. Am J Pathol 183(6):1936-44. [PubMed: 24266926]  [MGI Ref ID J:207935]

Mohamadzadeh M; Pfeiler EA; Brown JB; Zadeh M; Gramarossa M; Managlia E; Bere P; Sarraj B; Khan MW; Pakanati KC; Ansari MJ; O'Flaherty S; Barrett T; Klaenhammer TR. 2011. Regulation of induced colonic inflammation by Lactobacillus acidophilus deficient in lipoteichoic acid. Proc Natl Acad Sci U S A 108 Suppl 1:4623-30. [PubMed: 21282652]  [MGI Ref ID J:170355]

Montufar-Solis D; Schaefer J; Hicks MJ; Klein JR. 2008. Massive but selective cytokine dysregulation in the colon of IL-10 / mice revealed by multiplex analysis. Int Immunol 20(1):141-54. [PubMed: 18046045]  [MGI Ref ID J:129200]

Morise Z; Eppihimer M; Granger DN; Anderson DC; Grisham MB. 1999. Effects of lipopolysaccharide on endothelial cell adhesion molecule expression in interleukin-10 deficient mice. Inflammation 23(2):99-110. [PubMed: 10213266]  [MGI Ref ID J:56218]

Mucida D; Kutchukhidze N; Erazo A; Russo M; Lafaille JJ; Curotto de Lafaille MA. 2005. Oral tolerance in the absence of naturally occurring Tregs. J Clin Invest 115(7):1923-33. [PubMed: 15937545]  [MGI Ref ID J:99807]

Muhlbauer M; Chilton PM; Mitchell TC; Jobin C. 2008. Impaired Bcl3 up-regulation leads to enhanced lipopolysaccharide-induced interleukin (IL)-23P19 gene expression in IL-10(-/-) mice. J Biol Chem 283(21):14182-9. [PubMed: 18375954]  [MGI Ref ID J:137573]

Murai M; Turovskaya O; Kim G; Madan R; Karp CL; Cheroutre H; Kronenberg M. 2009. Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis. Nat Immunol 10(11):1178-84. [PubMed: 19783988]  [MGI Ref ID J:157749]

Murphy ML; Wille U; Villegas EN; Hunter CA; Farrell JP. 2001. IL-10 mediates susceptibility to Leishmania donovani infection. Eur J Immunol 31(10):2848-56. [PubMed: 11592059]  [MGI Ref ID J:72355]

Murphy SP; Fast LD; Hanna NN; Sharma S. 2005. Uterine NK cells mediate inflammation-induced fetal demise in IL-10-null mice. J Immunol 175(6):4084-90. [PubMed: 16148158]  [MGI Ref ID J:116699]

Murray PJ; Young RA. 1999. Increased antimycobacterial immunity in interleukin-10-deficient mice. Infect Immun 67(6):3087-95. [PubMed: 10338525]  [MGI Ref ID J:55136]

Murugaiyan G; Beynon V; Pires Da Cunha A; Joller N; Weiner HL. 2012. IFN-gamma limits Th9-mediated autoimmune inflammation through dendritic cell modulation of IL-27. J Immunol 189(11):5277-83. [PubMed: 23125412]  [MGI Ref ID J:190977]

Myers D Jr; Farris D; Hawley A; Wrobleski S; Chapman A; Stoolman L; Knibbs R; Strieter R; Wakefield T. 2002. Selectins influence thrombosis in a mouse model of experimental deep venous thrombosis. J Surg Res 108(2):212-21. [PubMed: 12505044]  [MGI Ref ID J:103110]

Nagamatsu K; Kuwae A; Konaka T; Nagai S; Yoshida S; Eguchi M; Watanabe M; Mimuro H; Koyasu S; Abe A. 2009. Bordetella evades the host immune system by inducing IL-10 through a type III effector, BopN. J Exp Med 206(13):3073-88. [PubMed: 20008527]  [MGI Ref ID J:155669]

Nagamine CM; Rogers AB; Fox JG; Schauer DB. 2008. Helicobacter hepaticus promotes azoxymethane-initiated colon tumorigenesis in BALB/c-IL10-deficient mice. Int J Cancer 122(4):832-8. [PubMed: 17957786]  [MGI Ref ID J:135558]

Naruse H; Hisamatsu T; Yamauchi Y; Chang JE; Matsuoka K; Kitazume MT; Arai K; Ando S; Kanai T; Kamada N; Hibi T. 2011. Intracellular bacteria recognition contributes to maximal interleukin (IL)-12 production by IL-10-deficient macrophages. Clin Exp Immunol 164(1):137-44. [PubMed: 21352199]  [MGI Ref ID J:170705]

Narushima S; DiMeo D; Tian J; Zhang J; Liu D; Berg DJ. 2008. 5-Lipoxygenase-derived lipid mediators are not required for the development of NSAID-induced inflammatory bowel disease in IL-10-/- mice. Am J Physiol Gastrointest Liver Physiol 294(2):G477-88. [PubMed: 18048478]  [MGI Ref ID J:132202]

Narushima S; Spitz DR; Oberley LW; Toyokuni S; Miyata T; Gunnett CA; Buettner GR; Zhang J; Ismail H; Lynch RG; Berg DJ. 2003. Evidence for oxidative stress in NSAID-induced colitis in IL10-/- mice. Free Radic Biol Med 34(9):1153-66. [PubMed: 12706496]  [MGI Ref ID J:119439]

Navid F; Boniotto M; Walker C; Ahrens K; Proksch E; Sparwasser T; Muller W; Schwarz T; Schwarz A. 2012. Induction of regulatory T cells by a murine beta-defensin. J Immunol 188(2):735-43. [PubMed: 22174455]  [MGI Ref ID J:180788]

Nemeth K; Leelahavanichkul A; Yuen PS; Mayer B; Parmelee A; Doi K; Robey PG; Leelahavanichkul K; Koller BH; Brown JM; Hu X; Jelinek I; Star RA; Mezey E. 2009. Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production. Nat Med 15(1):42-9. [PubMed: 19098906]  [MGI Ref ID J:146566]

Nemoto Y; Kanai T; Makita S; Okamoto R; Totsuka T; Takeda K; Watanabe M. 2007. Bone marrow retaining colitogenic CD4+ T cells may be a pathogenic reservoir for chronic colitis. Gastroenterology 132(1):176-89. [PubMed: 17241870]  [MGI Ref ID J:128223]

Neves P; Lampropoulou V; Calderon-Gomez E; Roch T; Stervbo U; Shen P; Kuhl AA; Loddenkemper C; Haury M; Nedospasov SA; Kaufmann SH; Steinhoff U; Calado DP; Fillatreau S. 2010. Signaling via the MyD88 adaptor protein in B cells suppresses protective immunity during Salmonella typhimurium infection. Immunity 33(5):777-90. [PubMed: 21093317]  [MGI Ref ID J:167006]

Ng RL; Scott NM; Strickland DH; Gorman S; Grimbaldeston MA; Norval M; Waithman J; Hart PH. 2013. Altered immunity and dendritic cell activity in the periphery of mice after long-term engraftment with bone marrow from ultraviolet-irradiated mice. J Immunol 190(11):5471-84. [PubMed: 23636055]  [MGI Ref ID J:204767]

Niikura M; Kamiya S; Kita K; Kobayashi F. 2008. Coinfection with nonlethal murine malaria parasites suppresses pathogenesis caused by Plasmodium berghei NK65. J Immunol 180(10):6877-84. [PubMed: 18453608]  [MGI Ref ID J:134868]

Nitahara-Kasahara Y; Hayashita-Kinoh H; Chiyo T; Nishiyama A; Okada H; Takeda S; Okada T. 2014. Dystrophic mdx mice develop severe cardiac and respiratory dysfunction following genetic ablation of the anti-inflammatory cytokine IL-10. Hum Mol Genet 23(15):3990-4000. [PubMed: 24659498]  [MGI Ref ID J:211195]

Noben-Trauth N; Lira R; Nagase H; Paul WE; Sacks DL. 2003. The relative contribution of IL-4 receptor signaling and IL-10 to susceptibility to Leishmania major. J Immunol 170(10):5152-8. [PubMed: 12734362]  [MGI Ref ID J:123822]

North RJ. 1998. Mice incapable of making IL-4 or IL-10 display normal resistance to infection with Mycobacterium tuberculosis. Clin Exp Immunol 113(1):55-8. [PubMed: 9697983]  [MGI Ref ID J:114201]

O'Mahony L; Feeney M; O'Halloran S; Murphy L; Kiely B; Fitzgibbon J; Lee G; O'Sullivan G; Shanahan F; Collins JK. 2001. Probiotic impact on microbial flora, inflammation and tumour development in IL-10 knockout mice. Aliment Pharmacol Ther 15(8):1219-25. [PubMed: 11472326]  [MGI Ref ID J:70926]

Oakley OR; Garvy BA; Humphreys S; Qureshi MH; Pomeroy C. 2008. Increased weight loss with reduced viral replication in interleukin-10 knock-out mice infected with murine cytomegalovirus. Clin Exp Immunol 151(1):155-64. [PubMed: 18005264]  [MGI Ref ID J:130172]

Oh SJ; Kim JH; Chung DH. 2013. NOD2-mediated suppression of CD55 on neutrophils enhances C5a generation during polymicrobial sepsis. PLoS Pathog 9(5):e1003351. [PubMed: 23675299]  [MGI Ref ID J:213406]

Ohman MK; Shen Y; Obimba CI; Wright AP; Warnock M; Lawrence DA; Eitzman DT. 2008. Visceral adipose tissue inflammation accelerates atherosclerosis in apolipoprotein E-deficient mice. Circulation 117(6):798-805. [PubMed: 18212290]  [MGI Ref ID J:145083]

Ohtani M; Nagai S; Kondo S; Mizuno S; Nakamura K; Tanabe M; Takeuchi T; Matsuda S; Koyasu S. 2008. Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells. Blood 112(3):635-43. [PubMed: 18492954]  [MGI Ref ID J:138434]

Okada K; Fujita T; Minamoto K; Liao H; Naka Y; Pinsky DJ. 2000. Potentiation of endogenous fibrinolysis and rescue from lung ischemia/reperfusion injury in interleukin (IL)-10-reconstituted IL-10 null mice. J Biol Chem 275(28):21468-76. [PubMed: 10806208]  [MGI Ref ID J:63469]

Okamura T; Sumitomo S; Morita K; Iwasaki Y; Inoue M; Nakachi S; Komai T; Shoda H; Miyazaki J; Fujio K; Yamamoto K. 2015. TGF-beta3-expressing CD4+CD25(-)LAG3+ regulatory T cells control humoral immune responses. Nat Commun 6:6329. [PubMed: 25695838]  [MGI Ref ID J:221793]

Oldenburg B; van Berge Henegouwen GP; Rennick D; Van Asbeck BS; Koningsberger JC. 2000. Iron supplementation affects the production of pro-inflammatory cytokines in IL-10 deficient mice. Eur J Clin Invest 30(6):505-10. [PubMed: 10849019]  [MGI Ref ID J:103312]

Olszak T; Neves JF; Dowds CM; Baker K; Glickman J; Davidson NO; Lin CS; Jobin C; Brand S; Sotlar K; Wada K; Katayama K; Nakajima A; Mizuguchi H; Kawasaki K; Nagata K; Muller W; Snapper SB; Schreiber S; Kaser A; Zeissig S; Blumberg RS. 2014. Protective mucosal immunity mediated by epithelial CD1d and IL-10. Nature 509(7501):497-502. [PubMed: 24717441]  [MGI Ref ID J:210436]

Onyeagocha C; Hossain MS; Kumar A; Jones RM; Roback J; Gewirtz AT. 2009. Latent cytomegalovirus infection exacerbates experimental colitis. Am J Pathol 175(5):2034-42. [PubMed: 19815702]  [MGI Ref ID J:154699]

Oppmann B; Lesley R; Blom B; Timans JC; Xu Y; Hunte B; Vega F; Yu N; Wang J; Singh K; Zonin F; Vaisberg E; Churakova T; Liu M; Gorman D; Wagner J; Zurawski S; Liu Y; Abrams JS; Moore KW; Rennick D; de Waal-Malefyt R; Hannum C; Bazan JF; Kastelein RA. 2000. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12 Immunity 13(5):715-25. [PubMed: 11114383]  [MGI Ref ID J:65966]

Ortega SB; Kashi VP; Tyler AF; Cunnusamy K; Mendoza JP; Karandikar NJ. 2013. The disease-ameliorating function of autoregulatory CD8 T cells is mediated by targeting of encephalitogenic CD4 T cells in experimental autoimmune encephalomyelitis. J Immunol 191(1):117-26. [PubMed: 23733879]  [MGI Ref ID J:205352]

Otero DC; Poli V; David M; Rickert RC. 2006. Cutting edge: inherent and acquired resistance to radiation-induced apoptosis in B cells: a pivotal role for STAT3. J Immunol 177(10):6593-7. [PubMed: 17082570]  [MGI Ref ID J:140502]

Padigel UM; Alexander J; Farrell JP. 2003. The role of interleukin-10 in susceptibility of BALB/c mice to infection with Leishmania mexicana and Leishmania amazonensis. J Immunol 171(7):3705-10. [PubMed: 14500669]  [MGI Ref ID J:85625]

Padigel UM; Farrell JP. 2005. Control of infection with Leishmania major in susceptible BALB/c mice lacking the common gamma-chain for FcR is associated with reduced production of IL-10 and TGF-beta by parasitized cells. J Immunol 174(10):6340-5. [PubMed: 15879134]  [MGI Ref ID J:99049]

Panes J; Aceituno M; Gil F; Miquel R; Pique JM; Salas A; McLean P. 2007. Efficacy of an inhibitor of adhesion molecule expression (GI270384X) in the treatment of experimental colitis. Am J Physiol Gastrointest Liver Physiol 293(4):G739-48. [PubMed: 17656448]  [MGI Ref ID J:126663]

Panjwani N; Mulvihill EE; Longuet C; Yusta B; Campbell JE; Brown TJ; Streutker C; Holland D; Cao X; Baggio LL; Drucker DJ. 2013. GLP-1 receptor activation indirectly reduces hepatic lipid accumulation but does not attenuate development of atherosclerosis in diabetic male ApoE(-/-) mice. Endocrinology 154(1):127-39. [PubMed: 23183176]  [MGI Ref ID J:194207]

Panthel K; Faller G; Haas R. 2003. Colonization of C57BL/6J and BALB/c wild-type and knockout mice with Helicobacter pylori: effect of vaccination and implications for innate and acquired immunity. Infect Immun 71(2):794-800. [PubMed: 12540559]  [MGI Ref ID J:81703]

Papiernik M; de Moraes ML; Pontoux C; Vasseur F; Penit C. 1998. Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency. Int Immunol 10(4):371-8. [PubMed: 9620592]  [MGI Ref ID J:110541]

Parekh VV; Wu L; Olivares-Villagomez D; Wilson KT; Van Kaer L. 2013. Activated invariant NKT cells control central nervous system autoimmunity in a mechanism that involves myeloid-derived suppressor cells. J Immunol 190(5):1948-60. [PubMed: 23345328]  [MGI Ref ID J:193488]

Park Y; Oh SJ; Chung DH. 2009. CD4(+)CD25(+) regulatory T cells attenuate Hypersensitivity Pneumonitis by suppressing IFN-gamma production by CD4(+) and CD8(+) T cells. J Leukoc Biol 86(6):1427-37. [PubMed: 19741155]  [MGI Ref ID J:155623]

Pasche B; Kalaydjiev S; Franz TJ; Kremmer E; Gailus-Durner V; Fuchs H; Hrabe de Angelis M; Lengeling A; Busch DH. 2005. Sex-dependent susceptibility to Listeria monocytogenes infection is mediated by differential interleukin-10 production. Infect Immun 73(9):5952-60. [PubMed: 16113316]  [MGI Ref ID J:100414]

Pattison MJ; MacKenzie KF; Elcombe SE; Arthur JS. 2013. IFNbeta autocrine feedback is required to sustain TLR induced production of MCP-1 in macrophages. FEBS Lett 587(10):1496-503. [PubMed: 23542035]  [MGI Ref ID J:197246]

Pattison MJ; Mackenzie KF; Arthur JS. 2012. Inhibition of JAKs in macrophages increases lipopolysaccharide-induced cytokine production by blocking IL-10-mediated feedback. J Immunol 189(6):2784-92. [PubMed: 22904308]  [MGI Ref ID J:189911]

Peng JK; Lin JS; Kung JT; Finkelman FD; Wu-Hsieh BA. 2005. The combined effect of IL-4 and IL-10 suppresses the generation of, but does not change the polarity of, type-1 T cells in Histoplasma infection. Int Immunol 17(2):193-205. [PubMed: 15642955]  [MGI Ref ID J:95565]

Perez-Asensio FJ; Perpina U; Planas AM; Pozas E. 2013. Interleukin-10 regulates progenitor differentiation and modulates neurogenesis in adult brain. J Cell Sci 126(Pt 18):4208-19. [PubMed: 23843621]  [MGI Ref ID J:210408]

Perez-de-Puig I; Martin A; Gorina R; de la Rosa X; Martinez E; Planas AM. 2013. Induction of hemeoxygenase-1 expression after inhibition of hemeoxygenase activity promotes inflammation and worsens ischemic brain damage in mice. Neuroscience 243:22-32. [PubMed: 23562577]  [MGI Ref ID J:201347]

Perona-Wright G; Jenkins SJ; Crawford A; Gray D; Pearce EJ; MacDonald AS. 2006. Distinct sources and targets of IL-10 during dendritic cell-driven Th1 and Th2 responses in vivo. Eur J Immunol 36(9):2367-75. [PubMed: 16917957]  [MGI Ref ID J:116745]

Perry JA; Olver CS; Burnett RC; Avery AC. 2005. Cutting edge: the acquisition of TLR tolerance during malaria infection impacts T cell activation. J Immunol 174(10):5921-5. [PubMed: 15879082]  [MGI Ref ID J:98996]

Pesce J; Kaviratne M; Ramalingam TR; Thompson RW; Urban JF Jr; Cheever AW; Young DA; Collins M; Grusby MJ; Wynn TA. 2006. The IL-21 receptor augments Th2 effector function and alternative macrophage activation. J Clin Invest 116(7):2044-55. [PubMed: 16778988]  [MGI Ref ID J:111712]

Pils MC; Pisano F; Fasnacht N; Heinrich JM; Groebe L; Schippers A; Rozell B; Jack RS; Muller W. 2010. Monocytes/macrophages and/or neutrophils are the target of IL-10 in the LPS endotoxemia model. Eur J Immunol 40(2):443-8. [PubMed: 19941312]  [MGI Ref ID J:157787]

Pimenta-Araujo R; Mascarell L; Huesca M; Cumano A; Bandeira A. 2002. Deoxyguanosine blocks allograft rejection of thymic epithelium but not lymphocyte infiltration and recognition. Eur J Immunol 32(1):77-86. [PubMed: 11754006]  [MGI Ref ID J:73937]

Pini M; Gove ME; Fayad R; Cabay RJ; Fantuzzi G. 2009. Adiponectin deficiency does not affect development and progression of spontaneous colitis in IL-10 knockout mice. Am J Physiol Gastrointest Liver Physiol 296(2):G382-7. [PubMed: 19074637]  [MGI Ref ID J:146374]

Pitt JM; Stavropoulos E; Redford PS; Beebe AM; Bancroft GJ; Young DB; O'Garra A. 2012. Blockade of IL-10 signaling during bacillus Calmette-Guerin vaccination enhances and sustains Th1, Th17, and innate lymphoid IFN-gamma and IL-17 responses and increases protection to Mycobacterium tuberculosis infection. J Immunol 189(8):4079-87. [PubMed: 22972927]  [MGI Ref ID J:190516]

Ploquin MJ; Eksmond U; Kassiotis G. 2011. B cells and TCR avidity determine distinct functions of CD4+ T cells in retroviral infection. J Immunol 187(6):3321-30. [PubMed: 21841129]  [MGI Ref ID J:179252]

Polyak S; Mach A; Porvasnik S; Dixon L; Conlon T; Erger KE; Acosta A; Wright AJ; Campbell-Thompson M; Zolotukhin I; Wasserfall C; Mah C. 2012. Identification of adeno-associated viral vectors suitable for intestinal gene delivery and modulation of experimental colitis. Am J Physiol Gastrointest Liver Physiol 302(3):G296-308. [PubMed: 22114116]  [MGI Ref ID J:183314]

Pompei L; Jang S; Zamlynny B; Ravikumar S; McBride A; Hickman SP; Salgame P. 2007. Disparity in IL-12 release in dendritic cells and macrophages in response to Mycobacterium tuberculosis is due to use of distinct TLRs. J Immunol 178(8):5192-9. [PubMed: 17404302]  [MGI Ref ID J:145274]

Pontoux C; Banz A; Papiernik M. 2002. Natural CD4 CD25(+) regulatory T cells control the burst of superantigen-induced cytokine production: the role of IL-10. Int Immunol 14(2):233-9. [PubMed: 11809742]  [MGI Ref ID J:113510]

Potteaux S; Esposito B; van Oostrom O; Brun V; Ardouin P; Groux H; Tedgui A; Mallat Z. 2004. Leukocyte-derived interleukin 10 is required for protection against atherosclerosis in low-density lipoprotein receptor knockout mice. Arterioscler Thromb Vasc Biol 24(8):1474-8. [PubMed: 15178562]  [MGI Ref ID J:102225]

Pratt JS; Sachen KL; Wood HD; Eaton KA; Young VB. 2006. Modulation of host immune responses by the cytolethal distending toxin of Helicobacter hepaticus. Infect Immun 74(8):4496-504. [PubMed: 16861635]  [MGI Ref ID J:112296]

Qureshi MH; Harmsen AG; Garvy BA. 2003. IL-10 modulates host responses and lung damage induced by Pneumocystis carinii infection. J Immunol 170(2):1002-9. [PubMed: 12517967]  [MGI Ref ID J:127133]

Raisanen-Sokolowski A; Glysing-Jensen T; Russell ME. 1998. Leukocyte-suppressing influences of interleukin (IL)-10 in cardiac allografts: insights from IL-10 knockout mice. Am J Pathol 153(5):1491-500. [PubMed: 9811341]  [MGI Ref ID J:50766]

Raisanen-Sokolowski A; Mottram PL; Glysing-Jensen T; Satoskar A; Russell ME. 1997. Heart transplants in interferon-gamma, interleukin 4, and interleukin 10 knockout mice. Recipient environment alters graft rejection. J Clin Invest 100(10):2449-56. [PubMed: 9366559]  [MGI Ref ID J:44346]

Rakoff-Nahoum S; Hao L; Medzhitov R. 2006. Role of toll-like receptors in spontaneous commensal-dependent colitis. Immunity 25(2):319-29. [PubMed: 16879997]  [MGI Ref ID J:113467]

Ramaswamy K; Kumar P; He YX. 2000. A role for parasite-induced PGE2 in IL-10-mediated host immunoregulation by skin stage schistosomula of Schistosoma mansoni. J Immunol 165(8):4567-74. [PubMed: 11035098]  [MGI Ref ID J:118566]

Ranatunga D; Hedrich CM; Wang F; McVicar DW; Nowak N; Joshi T; Feigenbaum L; Grant LR; Stager S; Bream JH. 2009. A human IL10 BAC transgene reveals tissue-specific control of IL-10 expression and alters disease outcome. Proc Natl Acad Sci U S A 106(40):17123-8. [PubMed: 19805095]  [MGI Ref ID J:153695]

Ray A; Basu S; Williams CB; Salzman NH; Dittel BN. 2012. A novel IL-10-independent regulatory role for B cells in suppressing autoimmunity by maintenance of regulatory T cells via GITR ligand. J Immunol 188(7):3188-98. [PubMed: 22368274]  [MGI Ref ID J:183107]

Redpath S; Angulo A; Gascoigne NR; Ghazal P. 1999. Murine cytomegalovirus infection down-regulates MHC class II expression on macrophages by induction of IL-10. J Immunol 162(11):6701-7. [PubMed: 10352288]  [MGI Ref ID J:112114]

Ren X; Akiyoshi K; Dziennis S; Vandenbark AA; Herson PS; Hurn PD; Offner H. 2011. Regulatory B cells limit CNS inflammation and neurologic deficits in murine experimental stroke. J Neurosci 31(23):8556-63. [PubMed: 21653859]  [MGI Ref ID J:191555]

Rhodes KA; Andrew EM; Newton DJ; Tramonti D; Carding SR. 2008. A subset of IL-10-producing gammadelta T cells protect the liver from Listeria-elicited, CD8(+) T cell-mediated injury. Eur J Immunol 38(8):2274-83. [PubMed: 18624301]  [MGI Ref ID J:138563]

Richter K; Oxenius A. 2013. Non-neutralizing antibodies protect from chronic LCMV infection independently of activating FcgammaR or complement. Eur J Immunol 43(9):2349-60. [PubMed: 23749374]  [MGI Ref ID J:201331]

Rifa'i M; Shi Z; Zhang SY; Lee YH; Shiku H; Isobe K; Suzuki H. 2008. CD8+CD122+ regulatory T cells recognize activated T cells via conventional MHC class I-alphabetaTCR interaction and become IL-10-producing active regulatory cells. Int Immunol 20(7):937-47. [PubMed: 18495626]  [MGI Ref ID J:137065]

Ring S; Enk AH; Mahnke K. 2011. Regulatory T cells from IL-10-deficient mice fail to suppress contact hypersensitivity reactions due to lack of adenosine production. J Invest Dermatol 131(7):1494-502. [PubMed: 21430704]  [MGI Ref ID J:182075]

Ring S; Schafer SC; Mahnke K; Lehr HA; Enk AH. 2006. CD4+ CD25+ regulatory T cells suppress contact hypersensitivity reactions by blocking influx of effector T cells into inflamed tissue. Eur J Immunol 36(11):2981-92. [PubMed: 17048272]  [MGI Ref ID J:117011]

Rivollier A; He J; Kole A; Valatas V; Kelsall BL. 2012. Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon. J Exp Med 209(1):139-55. [PubMed: 22231304]  [MGI Ref ID J:181701]

Rizzo LV; Morawetz RA; Miller-Rivero NE; Choi R; Wiggert B; Chan CC; Morse HC 3rd; Nussenblatt RB; Caspi RR. 1999. IL-4 and IL-10 are both required for the induction of oral tolerance. J Immunol 162(5):2613-22. [PubMed: 10072503]  [MGI Ref ID J:110850]

Roach DR; Martin E; Bean AG; Rennick DM; Briscoe H; Britton WJ. 2001. Endogenous inhibition of antimycobacterial immunity by IL-10 varies between mycobacterial species. Scand J Immunol 54(1-2):163-70. [PubMed: 11439163]  [MGI Ref ID J:80909]

Roberts CT; White CA; Wiemer NG; Ramsay A; Robertson SA. 2003. Altered placental development in interleukin-10 null mutant mice. Placenta 24 Suppl A:S94-9. [PubMed: 12842419]  [MGI Ref ID J:113180]

Robertson SA; Care AS; Skinner RJ. 2007. Interleukin 10 regulates inflammatory cytokine synthesis to protect against lipopolysaccharide-induced abortion and fetal growth restriction in mice. Biol Reprod 76(5):738-48. [PubMed: 17215490]  [MGI Ref ID J:121947]

Robertson SA; Skinner RJ; Care AS. 2006. Essential role for IL-10 in resistance to lipopolysaccharide-induced preterm labor in mice. J Immunol 177(7):4888-96. [PubMed: 16982931]  [MGI Ref ID J:139303]

Rodriguez W; Mold C; Kataranovski M; Hutt JA; Marnell LL; Verbeek JS; Du Clos TW. 2007. C-reactive protein-mediated suppression of nephrotoxic nephritis: role of macrophages, complement, and Fcgamma receptors. J Immunol 178(1):530-8. [PubMed: 17182593]  [MGI Ref ID J:141920]

Roelofs-Haarhuis K; Wu X; Gleichmann E. 2004. Oral tolerance to nickel requires CD4+ invariant NKT cells for the infectious spread of tolerance and the induction of specific regulatory T cells. J Immunol 173(2):1043-50. [PubMed: 15240692]  [MGI Ref ID J:91933]

Roffe E; Rothfuchs AG; Santiago HC; Marino AP; Ribeiro-Gomes FL; Eckhaus M; Antonelli LR; Murphy PM. 2012. IL-10 limits parasite burden and protects against fatal myocarditis in a mouse model of Trypanosoma cruzi infection. J Immunol 188(2):649-60. [PubMed: 22156594]  [MGI Ref ID J:180798]

Ronet C; Hauyon-La Torre Y; Revaz-Breton M; Mastelic B; Tacchini-Cottier F; Louis J; Launois P. 2010. Regulatory B cells shape the development of Th2 immune responses in BALB/c mice infected with Leishmania major through IL-10 production. J Immunol 184(2):886-94. [PubMed: 19966209]  [MGI Ref ID J:159430]

Roque S; Nobrega C; Appelberg R; Correia-Neves M. 2007. IL-10 underlies distinct susceptibility of BALB/c and C57BL/6 mice to Mycobacterium avium infection and influences efficacy of antibiotic therapy. J Immunol 178(12):8028-35. [PubMed: 17548640]  [MGI Ref ID J:148580]

Rosborough BR; Raich-Regue D; Matta BM; Lee K; Gan B; DePinho RA; Hackstein H; Boothby M; Turnquist HR; Thomson AW. 2013. Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1, and regulatory T-cell induction. Blood 121(18):3619-30. [PubMed: 23444404]  [MGI Ref ID J:197572]

Rothfuchs AG; Gigliotti D; Palmblad K; Andersson U; Wigzell H; Rottenberg ME. 2001. IFN-alphabeta-dependent, IFN-gamma secretion by bone marrow-derived macrophages controls an intracellular bacterial infection. J Immunol 167(11):6453-61. [PubMed: 11714812]  [MGI Ref ID J:72825]

Roy N; Barnett M; Knoch B; Dommels Y; McNabb W. 2007. Nutrigenomics applied to an animal model of Inflammatory Bowel Diseases: Transcriptomic analysis of the effects of eicosapentaenoic acid- and arachidonic acid-enriched diets. Mutat Res 622(1-2):103-16. [PubMed: 17574631]  [MGI Ref ID J:124308]

Rubtsov YP; Rasmussen JP; Chi EY; Fontenot J; Castelli L; Ye X; Treuting P; Siewe L; Roers A; Henderson WR Jr; Muller W; Rudensky AY. 2008. Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity 28(4):546-58. [PubMed: 18387831]  [MGI Ref ID J:134513]

Ruiz PA; Shkoda A; Kim SC; Sartor RB; Haller D. 2005. IL-10 gene-deficient mice lack TGF-beta/Smad signaling and fail to inhibit proinflammatory gene expression in intestinal epithelial cells after the colonization with colitogenic Enterococcus faecalis. J Immunol 174(5):2990-9. [PubMed: 15728512]  [MGI Ref ID J:97722]

Ryan SO; Johnson JL; Cobb BA. 2013. Neutrophils confer T cell resistance to myeloid-derived suppressor cell-mediated suppression to promote chronic inflammation. J Immunol 190(10):5037-47. [PubMed: 23576679]  [MGI Ref ID J:202566]

Rynda A; Maddaloni M; Mierzejewska D; Ochoa-Reparaz J; Maslanka T; Crist K; Riccardi C; Barszczewska B; Fujihashi K; McGhee JR; Pascual DW. 2008. Low-dose tolerance is mediated by the microfold cell ligand, reovirus protein sigma1. J Immunol 180(8):5187-200. [PubMed: 18390700]  [MGI Ref ID J:134246]

Saadane A; Soltys J; Berger M. 2005. Role of IL-10 deficiency in excessive nuclear factor-kappaB activation and lung inflammation in cystic fibrosis transmembrane conductance regulator knockout mice. J Allergy Clin Immunol 115(2):405-11. [PubMed: 15696103]  [MGI Ref ID J:105450]

Sadler CH; Rutitzky LI; Stadecker MJ; Wilson RA. 2003. IL-10 is crucial for the transition from acute to chronic disease state during infection of mice with Schistosoma mansoni. Eur J Immunol 33(4):880-8. [PubMed: 12672053]  [MGI Ref ID J:115702]

Sahay B; Singh A; Gnanamani A; Patsey RL; Blalock JE; Sellati TJ. 2011. CD14 signaling reciprocally controls collagen deposition and turnover to regulate the development of lyme arthritis. Am J Pathol 178(2):724-34. [PubMed: 21281805]  [MGI Ref ID J:169078]

Sanni LA; Jarra W; Li C; Langhorne J. 2004. Cerebral edema and cerebral hemorrhages in interleukin-10-deficient mice infected with Plasmodium chabaudi. Infect Immun 72(5):3054-8. [PubMed: 15102820]  [MGI Ref ID J:89479]

Sarangi PP; Sehrawat S; Suvas S; Rouse BT. 2008. IL-10 and natural regulatory T cells: two independent anti-inflammatory mechanisms in herpes simplex virus-induced ocular immunopathology. J Immunol 180(9):6297-306. [PubMed: 18424753]  [MGI Ref ID J:134522]

Sarasin-Filipowicz M; Wang X; Yan M; Duong FH; Poli V; Hilton DJ; Zhang DE; Heim MH. 2009. Alpha interferon induces long-lasting refractoriness of JAK-STAT signaling in the mouse liver through induction of USP18/UBP43. Mol Cell Biol 29(17):4841-51. [PubMed: 19564419]  [MGI Ref ID J:152613]

Sasaki H; Hou L; Belani A; Wang CY; Uchiyama T; Muller R; Stashenko P. 2000. IL-10, but not IL-4, suppresses infection-stimulated bone resorption in vivo. J Immunol 165(7):3626-30. [PubMed: 11034365]  [MGI Ref ID J:118728]

Sasaki H; Okamatsu Y; Kawai T; Kent R; Taubman M; Stashenko P. 2004. The interleukin-10 knockout mouse is highly susceptible to Porphyromonas gingivalis-induced alveolar bone loss. J Periodontal Res 39(6):432-41. [PubMed: 15491348]  [MGI Ref ID J:103519]

Sawant DV; Sehra S; Nguyen ET; Jadhav R; Englert K; Shinnakasu R; Hangoc G; Broxmeyer HE; Nakayama T; Perumal NB; Kaplan MH; Dent AL. 2012. Bcl6 controls the Th2 inflammatory activity of regulatory T cells by repressing Gata3 function. J Immunol 189(10):4759-69. [PubMed: 23053511]  [MGI Ref ID J:190587]

Sayi A; Kohler E; Toller IM; Flavell RA; Muller W; Roers A; Muller A. 2011. TLR-2-activated B cells suppress Helicobacter-induced preneoplastic gastric immunopathology by inducing T regulatory-1 cells. J Immunol 186(2):878-90. [PubMed: 21149607]  [MGI Ref ID J:168773]

Scapini P; Lamagna C; Hu Y; Lee K; Tang Q; Defranco AL; Lowell CA. 2011. B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice. Proc Natl Acad Sci U S A 108(41):E823-32. [PubMed: 21911371]  [MGI Ref ID J:177380]

Schaefer JS; Montufar-Solis D; Vigneswaran N; Klein JR. 2011. Selective upregulation of microRNA expression in peripheral blood leukocytes in IL-10-/- mice precedes expression in the colon. J Immunol 187(11):5834-41. [PubMed: 22043014]  [MGI Ref ID J:179720]

Scheckelhoff M; Deepe GS Jr. 2005. A deficiency in gamma interferon or interleukin-10 modulates T-Cell-dependent responses to heat shock protein 60 from Histoplasma capsulatum. Infect Immun 73(4):2129-34. [PubMed: 15784555]  [MGI Ref ID J:97204]

Scheinin T; Butler DM; Salway F; Scallon B; Feldmann M. 2003. Validation of the interleukin-10 knockout mouse model of colitis: antitumour necrosis factor-antibodies suppress the progression of colitis. Clin Exp Immunol 133(1):38-43. [PubMed: 12823276]  [MGI Ref ID J:84100]

Schmitt EG; Haribhai D; Jeschke JC; Co DO; Ziegelbauer J; Yan K; Iwakura Y; Mishra MK; Simpson P; Salzman NH; Williams CB. 2013. Chronic follicular bronchiolitis requires antigen-specific regulatory T cell control to prevent fatal disease progression. J Immunol 191(11):5460-76. [PubMed: 24163409]  [MGI Ref ID J:207015]

Schmitt EG; Haribhai D; Williams JB; Aggarwal P; Jia S; Charbonnier LM; Yan K; Lorier R; Turner A; Ziegelbauer J; Georgiev P; Simpson P; Salzman NH; Hessner MJ; Broeckel U; Chatila TA; Williams CB. 2012. IL-10 Produced by Induced Regulatory T Cells (iTregs) Controls Colitis and Pathogenic Ex-iTregs during Immunotherapy. J Immunol 189(12):5638-48. [PubMed: 23125413]  [MGI Ref ID J:190976]

Schulke S; Wolfheimer S; Gadermaier G; Wangorsch A; Siebeneicher S; Briza P; Spreitzer I; Schiller D; Loeschner B; Uematsu S; Ryffel B; Akira S; Waibler Z; Vieths S; Toda M; Scheurer S. 2014. Prevention of intestinal allergy in mice by rflaA:Ova is associated with enforced antigen processing and TLR5-dependent IL-10 secretion by mDC. PLoS One 9(2):e87822. [PubMed: 24516564]  [MGI Ref ID J:212957]

Schwandt T; Schumak B; Gielen GH; Jungerkes F; Schmidbauer P; Klocke K; Staratschek-Jox A; van Rooijen N; Kraal G; Ludwig-Portugall I; Franken L; Wehner S; Kalff JC; Weber O; Kirschning C; Coch C; Kalinke U; Wenzel J; Kurts C; Zawatzky R; Holzmann B; Layland L; Schultze JL; Burgdorf S; den Haan JM; Knolle PA; Limmer A. 2012. Expression of type I interferon by splenic macrophages suppresses adaptive immunity during sepsis. EMBO J 31(1):201-13. [PubMed: 22036947]  [MGI Ref ID J:180238]

Scumpia PO; Delano MJ; Kelly KM; O'Malley KA; Efron PA; McAuliffe PF; Brusko T; Ungaro R; Barker T; Wynn JL; Atkinson MA; Reeves WH; Salzler MJ; Moldawer LL. 2006. Increased natural CD4+CD25+ regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis. J Immunol 177(11):7943-9. [PubMed: 17114466]  [MGI Ref ID J:140690]

Seewaldt S; Alferink J; Forster I. 2002. Interleukin-10 is crucial for maintenance but not for developmental induction of peripheral T cell tolerance. Eur J Immunol 32(12):3607-16. [PubMed: 12516547]  [MGI Ref ID J:80858]

Segal BM; Dwyer BK; Shevach EM. 1998. An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease. J Exp Med 187(4):537-46. [PubMed: 9463404]  [MGI Ref ID J:118559]

Selvaraj RK; Geiger TL. 2008. Mitigation of Experimental Allergic Encephalomyelitis by TGF-{beta} Induced Foxp3+ Regulatory T Lymphocytes through the Induction of Anergy and Infectious Tolerance. J Immunol 180(5):2830-2838. [PubMed: 18292504]  [MGI Ref ID J:131562]

Serreze DV; Chapman HD; Post CM; Johnson EA; Suarez-Pinzon WL; Rabinovitch A. 2001. Th1 to Th2 cytokine shifts in nonobese diabetic mice: sometimes an outcome, rather than the cause, of diabetes resistance elicited by immunostimulation. J Immunol 166(2):1352-9. [PubMed: 11145720]  [MGI Ref ID J:109883]

Settles EW; Moser LA; Harris TH; Knoll LJ. 2014. Toxoplasma gondii upregulates interleukin-12 to prevent Plasmodium berghei-induced experimental cerebral malaria. Infect Immun 82(3):1343-53. [PubMed: 24396042]  [MGI Ref ID J:209405]

Sewnath ME; Olszyna DP; Birjmohun R; ten Kate FJ; Gouma DJ; van Der Poll T. 2001. IL-10-deficient mice demonstrate multiple organ failure and increased mortality during Escherichia coli peritonitis despite an accelerated bacterial clearance. J Immunol 166(10):6323-31. [PubMed: 11342656]  [MGI Ref ID J:69347]

Shaler CR; Kugathasan K; McCormick S; Damjanovic D; Horvath C; Small CL; Jeyanathan M; Chen X; Yang PC; Xing Z. 2011. Pulmonary mycobacterial granuloma increased IL-10 production contributes to establishing a symbiotic host-microbe microenvironment. Am J Pathol 178(4):1622-34. [PubMed: 21406169]  [MGI Ref ID J:169923]

Shattuck-Brandt RL; Varilek GW; Radhika A; Yang F; Washington MK; DuBois RN. 2000. Cyclooxygenase 2 expression is increased in the stroma of colon carcinomas from IL-10(-/-) mice Gastroenterology 118(2):337-45. [PubMed: 10648462]  [MGI Ref ID J:60015]

Shaw MH; Freeman GJ; Scott MF; Fox BA; Bzik DJ; Belkaid Y; Yap GS. 2006. Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation. J Immunol 176(12):7263-71. [PubMed: 16751369]  [MGI Ref ID J:132232]

Sheikh SZ; Hegazi RA; Kobayashi T; Onyiah JC; Russo SM; Matsuoka K; Sepulveda AR; Li F; Otterbein LE; Plevy SE. 2011. An anti-inflammatory role for carbon monoxide and heme oxygenase-1 in chronic Th2-mediated murine colitis. J Immunol 186(9):5506-13. [PubMed: 21444764]  [MGI Ref ID J:173113]

Sheil B; MacSharry J; O'Callaghan L; O'Riordan A; Waters A; Morgan J; Collins JK; O'Mahony L; Shanahan F. 2006. Role of interleukin (IL-10) in probiotic-mediated immune modulation: an assessment in wild-type and IL-10 knock-out mice. Clin Exp Immunol 144(2):273-80. [PubMed: 16634801]  [MGI Ref ID J:108129]

Shen P; Roch T; Lampropoulou V; O'Connor RA; Stervbo U; Hilgenberg E; Ries S; Dang VD; Jaimes Y; Daridon C; Li R; Jouneau L; Boudinot P; Wilantri S; Sakwa I; Miyazaki Y; Leech MD; McPherson RC; Wirtz S; Neurath M; Hoehlig K; Meinl E; Grutzkau A; Grun JR; Horn K; Kuhl AA; Dorner T; Bar-Or A; Kaufmann SH; Anderton SM; Fillatreau S. 2014. IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases. Nature 507(7492):366-70. [PubMed: 24572363]  [MGI Ref ID J:208891]

Shen Z; Feng Y; Rogers AB; Rickman B; Whary MT; Xu S; Clapp KM; Boutin SR; Fox JG. 2009. Cytolethal distending toxin promotes Helicobacter cinaedi-associated typhlocolitis in interleukin-10-deficient mice. Infect Immun 77(6):2508-16. [PubMed: 19307212]  [MGI Ref ID J:149367]

Shi LZ; Kalupahana NS; Turnis ME; Neale G; Hock H; Vignali DA; Chi H. 2013. Inhibitory role of the transcription repressor Gfi1 in the generation of thymus-derived regulatory T cells. Proc Natl Acad Sci U S A 110(34):E3198-205. [PubMed: 23918371]  [MGI Ref ID J:200673]

Shi M; Ye Z; Umeshappa KS; Moyana T; Xiang J. 2007. Alpha tumor necrosis factor contributes to CD8(+) T cell survival in the transition phase. Biochem Biophys Res Commun 360(3):702-7. [PubMed: 17618911]  [MGI Ref ID J:123025]

Shibata Y; Foster LA; Kurimoto M; Okamura H; Nakamura RM; Kawajiri K; Justice JP; Van Scott MR; Myrvik QN; Metzger WJ. 1998. Immunoregulatory roles of IL-10 in innate immunity: IL-10 inhibits macrophage production of IFN-gamma-inducing factors but enhances NK cell production of IFN-gamma. J Immunol 161(8):4283-8. [PubMed: 9780204]  [MGI Ref ID J:112144]

Shibata Y; Gabbard J; Yamashita M; Tsuji S; Smith M; Nishiyama A; Henriksen RA; Myrvik QN. 2006. Heat-killed BCG induces biphasic cyclooxygenase 2+ splenic macrophage formation--role of IL-10 and bone marrow precursors. J Leukoc Biol 80(3):590-8. [PubMed: 16822852]  [MGI Ref ID J:112580]

Shibata Y; Nishiyama A; Ohata H; Gabbard J; Myrvik QN; Henriksen RA. 2005. Differential effects of IL-10 on prostaglandin H synthase-2 expression and prostaglandin E2 biosynthesis between spleen and bone marrow macrophages. J Leukoc Biol 77(4):544-51. [PubMed: 15657087]  [MGI Ref ID J:97441]

Shiraki M; Aihara H; Kinouchi Y; Takahashi S; Oki M; Noguchi M; Takahashi K; Miyazaki J; Shimosegawa T. 2004. IL-12 p40 prevents the development of chronic enterocolitis in IL-10-deficient mice. Lab Invest 84(11):1491-500. [PubMed: 15448706]  [MGI Ref ID J:94422]

Shmelkov SV; Butler JM; Hooper AT; Hormigo A; Kushner J; Milde T; St Clair R; Baljevic M; White I; Jin DK; Chadburn A; Murphy AJ; Valenzuela DM; Gale NW; Thurston G; Yancopoulos GD; D'Angelica M; Kemeny N; Lyden D; Rafii S. 2008. CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors. J Clin Invest 118(6):2111-20. [PubMed: 18497886]  [MGI Ref ID J:137714]

Shreiner AB; Murdock BJ; Sadighi Akha AA; Falkowski NR; Christensen PJ; White ES; Hogaboam CM; Huffnagle GB. 2012. Repeated Exposure to Aspergillus fumigatus Conidia Results in CD4+ T Cell-Dependent and -Independent Pulmonary Arterial Remodeling in a Mixed Th1/Th2/Th17 Microenvironment That Requires Interleukin-4 (IL-4) and IL-10. Infect Immun 80(1):388-97. [PubMed: 22064716]  [MGI Ref ID J:179004]

Siegmund B; Sennello JA; Lehr HA; Batra A; Fedke I; Zeitz M; Fantuzzi G. 2004. Development of intestinal inflammation in double IL-10- and leptin-deficient mice. J Leukoc Biol 76(4):782-6. [PubMed: 15240754]  [MGI Ref ID J:93117]

Siewe L; Bollati-Fogolin M; Wickenhauser C; Krieg T; Muller W; Roers A. 2006. Interleukin-10 derived from macrophages and/or neutrophils regulates the inflammatory response to LPS but not the response to CpG DNA. Eur J Immunol 36(12):3248-55. [PubMed: 17111348]  [MGI Ref ID J:117122]

Sikka G; Miller KL; Steppan J; Pandey D; Jung SM; Fraser CD 3rd; Ellis C; Ross D; Vandegaer K; Bedja D; Gabrielson K; Walston JD; Berkowitz DE; Barouch LA. 2013. Interleukin 10 knockout frail mice develop cardiac and vascular dysfunction with increased age. Exp Gerontol 48(2):128-35. [PubMed: 23159957]  [MGI Ref ID J:210217]

Silvestre JS; Mallat Z; Tamarat R; Duriez M; Tedgui A; Levy BI. 2001. Regulation of matrix metalloproteinase activity in ischemic tissue by interleukin-10: role in ischemia-induced angiogenesis. Circ Res 89(3):259-64. [PubMed: 11485976]  [MGI Ref ID J:115612]

Sindhava V; Woodman ME; Stevenson B; Bondada S. 2010. Interleukin-10 mediated autoregulation of murine B-1 B-cells and its role in Borrelia hermsii infection. PLoS One 5(7):e11445. [PubMed: 20625435]  [MGI Ref ID J:163123]

Sing A; Roggenkamp A; Geiger AM; Heesemann J. 2002. Yersinia enterocolitica evasion of the host innate immune response by V antigen-induced IL-10 production of macrophages is abrogated in IL-10-deficient mice. J Immunol 168(3):1315-21. [PubMed: 11801671]  [MGI Ref ID J:127288]

Singh UP; Singh S; Singh R; Karls RK; Quinn FD; Potter ME; Lillard JW Jr. 2007. Influence of Mycobacterium avium subsp. paratuberculosis on colitis development and specific immune responses during disease. Infect Immun 75(8):3722-8. [PubMed: 17502388]  [MGI Ref ID J:123357]

Singh UP; Singh S; Taub DD; Lillard JW Jr. 2003. Inhibition of IFN-gamma-inducible protein-10 abrogates colitis in IL-10(-/-) mice. J Immunol 171(3):1401-6. [PubMed: 12874231]  [MGI Ref ID J:84654]

Sinha P; Clements VK; Bunt SK; Albelda SM; Ostrand-Rosenberg S. 2007. Cross-talk between myeloid-derived suppressor cells and macrophages subverts tumor immunity toward a type 2 response. J Immunol 179(2):977-83. [PubMed: 17617589]  [MGI Ref ID J:149400]

Skelsey ME; Mayhew E; Niederkorn JY. 2003. CD25+, interleukin-10-producing CD4+ T cells are required for suppressor cell production and immune privilege in the anterior chamber of the eye. Immunology 110(1):18-29. [PubMed: 12941137]  [MGI Ref ID J:113598]

Slight SR; Monin L; Gopal R; Avery L; Davis M; Cleveland H; Oury TD; Rangel-Moreno J; Khader SA. 2013. IL-10 Restrains IL-17 to Limit Lung Pathology Characteristics following Pulmonary Infection with Francisella tularensis Live Vaccine Strain. Am J Pathol 183(5):1397-404. [PubMed: 24007881]  [MGI Ref ID J:202032]

Sohn BH; Moon HB; Kim TY; Kang HS; Bae YS; Lee KK; Kim SJ. 2001. Interleukin-10 up-regulates tumour-necrosis-factor-alpha-related apoptosis-inducing ligand (TRAIL) gene expression in mammary epithelial cells at the involution stage. Biochem J 360(Pt 1):31-8. [PubMed: 11695989]  [MGI Ref ID J:128126]

Soltys J; Bonfield T; Chmiel J; Berger M. 2002. Functional IL-10 deficiency in the lung of cystic fibrosis (cftr(-/-)) and IL-10 knockout mice causes increased expression and function of B7 costimulatory molecules on alveolar macrophages. J Immunol 168(4):1903-10. [PubMed: 11823525]  [MGI Ref ID J:74476]

Sonderegger FL; Ma Y; Maylor-Hagan H; Brewster J; Huang X; Spangrude GJ; Zachary JF; Weis JH; Weis JJ. 2012. Localized production of IL-10 suppresses early inflammatory cell infiltration and subsequent development of IFN-gamma-mediated Lyme arthritis. J Immunol 188(3):1381-93. [PubMed: 22180617]  [MGI Ref ID J:180776]

Sonoda KH; Faunce DE; Taniguchi M; Exley M; Balk S; Stein-Streilein J. 2001. NK T cell-derived IL-10 is essential for the differentiation of antigen-specific T regulatory cells in systemic tolerance. J Immunol 166(1):42-50. [PubMed: 11123275]  [MGI Ref ID J:125981]

Spach KM; Nashold FE; Dittel BN; Hayes CE. 2006. IL-10 signaling is essential for 1,25-dihydroxyvitamin D3-mediated inhibition of experimental autoimmune encephalomyelitis. J Immunol 177(9):6030-7. [PubMed: 17056528]  [MGI Ref ID J:140527]

Specht S; Volkmann L; Wynn T; Hoerauf A. 2004. Interleukin-10 (IL-10) counterregulates IL-4-dependent effector mechanisms in Murine Filariasis. Infect Immun 72(11):6287-93. [PubMed: 15501755]  [MGI Ref ID J:93273]

Speiran K; Bailey DP; Fernando J; Macey M; Barnstein B; Kolawole M; Curley D; Watowich SS; Murray PJ; Oskeritzian C; Ryan JJ. 2009. Endogenous suppression of mast cell development and survival by IL-4 and IL-10. J Leukoc Biol 85(5):826-36. [PubMed: 19228815]  [MGI Ref ID J:149777]

Spence S; Fitzsimons A; Boyd CR; Kessler J; Fitzgerald D; Elliott J; Gabhann JN; Smith S; Sica A; Hams E; Saunders SP; Jefferies CA; Fallon PG; McAuley DF; Kissenpfennig A; Johnston JA. 2013. Suppressors of cytokine signaling 2 and 3 diametrically control macrophage polarization. Immunity 38(1):66-78. [PubMed: 23177319]  [MGI Ref ID J:192314]

Spencer DM; Veldman GM; Banerjee S; Willis J; Levine AD. 2002. Distinct inflammatory mechanisms mediate early versus late colitis in mice. Gastroenterology 122(1):94-105. [PubMed: 11781285]  [MGI Ref ID J:73628]

Spight D; Zhao B; Haas M; Wert S; Denenberg A; Shanley TP. 2005. Immunoregulatory effects of regulated, lung-targeted expression of IL-10 in vivo. Am J Physiol Lung Cell Mol Physiol 288(2):L251-65. [PubMed: 15466252]  [MGI Ref ID J:101234]

Spolski R; Kim HP; Zhu W; Levy DE; Leonard WJ. 2009. IL-21 mediates suppressive effects via its induction of IL-10. J Immunol 182(5):2859-67. [PubMed: 19234181]  [MGI Ref ID J:146251]

Srivastava AS; Feng Z; Mishra R; Malhotra R; Kim HS; Carrier E. 2007. Embryonic stem cells ameliorate piroxicam-induced colitis in IL10-/- KO mice. Biochem Biophys Res Commun 361(4):953-9. [PubMed: 17692287]  [MGI Ref ID J:124266]

Stein P; Weber M; Prufer S; Schmid B; Schmitt E; Probst HC; Waisman A; Langguth P; Schild H; Radsak MP. 2011. Regulatory T cells and IL-10 independently counterregulate cytotoxic T lymphocyte responses induced by transcutaneous immunization. PLoS One 6(11):e27911. [PubMed: 22114725]  [MGI Ref ID J:180954]

Stone SC; Rossetti RA; Bolpetti A; Boccardo E; Souza PS; Lepique AP. 2014. HPV16-associated tumors control myeloid cell homeostasis in lymphoid organs, generating a suppressor environment for T cells. J Leukoc Biol 96(4):619-31. [PubMed: 24970861]  [MGI Ref ID J:220048]

Sturlan S; Oberhuber G; Beinhauer BG; Tichy B; Kappel S; Wang J; Rogy MA. 2001. Interleukin-10-deficient mice and inflammatory bowel disease associated cancer development. Carcinogenesis 22(4):665-71. [PubMed: 11285204]  [MGI Ref ID J:68476]

Sugimoto K; Ogawa A; Shimomura Y; Nagahama K; Mizoguchi A; Bhan AK. 2007. Inducible IL-12-producing B cells regulate Th2-mediated intestinal inflammation. Gastroenterology 133(1):124-36. [PubMed: 17631137]  [MGI Ref ID J:128298]

Sullivan VV; Hawley AE; Farris DM; Knipp BS; Varga AJ; Wrobleski SK; Thanapron P; Eagleton MJ; Myers DD; Fowlkes JB; Wakefield TW. 2003. Decrease in fibrin content of venous thrombi in selectin-deficient mice. J Surg Res 109(1):1-7. [PubMed: 12591228]  [MGI Ref ID J:119317]

Sumitomo S; Fujio K; Okamura T; Morita K; Ishigaki K; Suzukawa K; Kanaya K; Kondo K; Yamasoba T; Furukawa A; Kitahara N; Shoda H; Shibuya M; Okamoto A; Yamamoto K. 2013. Transcription factor early growth response 3 is associated with the TGF-beta1 expression and the regulatory activity of CD4-positive T cells in vivo. J Immunol 191(5):2351-9. [PubMed: 23904169]  [MGI Ref ID J:205814]

Sun K; Metzger DW. 2008. Inhibition of pulmonary antibacterial defense by interferon-gamma during recovery from influenza infection. Nat Med 14(5):558-64. [PubMed: 18438414]  [MGI Ref ID J:136669]

Suzuki Y; Sher A; Yap G; Park D; Neyer LE; Liesenfeld O; Fort M; Kang H; Gufwoli E. 2000. IL-10 is required for prevention of necrosis in the small intestine and mortality in both genetically resistant BALB/c and susceptible C57BL/6 mice following peroral infection with Toxoplasma gondii. J Immunol 164(10):5375-82. [PubMed: 10799901]  [MGI Ref ID J:62121]

Svensson L; Arvola M; Sallstrom M; Holmdahl R; Mattsson R. 2001. The Th2 cytokines IL-4 and IL-10 are not crucial for the completion of allogeneic pregnancy in mice. J Reprod Immunol 51(1):3-7. [PubMed: 11438376]  [MGI Ref ID J:70597]

Szalay G; Sauter M; Hald J; Weinzierl A; Kandolf R; Klingel K. 2006. Sustained nitric oxide synthesis contributes to immunopathology in ongoing myocarditis attributable to interleukin-10 disorders. Am J Pathol 169(6):2085-93. [PubMed: 17148671]  [MGI Ref ID J:116221]

Tadagavadi RK; Reeves WB. 2010. Endogenous IL-10 attenuates cisplatin nephrotoxicity: role of dendritic cells. J Immunol 185(8):4904-11. [PubMed: 20844196]  [MGI Ref ID J:219402]

Takabayshi K; Corr M; Hayashi T; Redecke V; Beck L; Guiney D; Sheppard D; Raz E. 2006. Induction of a homeostatic circuit in lung tissue by microbial compounds. Immunity 24(4):475-87. [PubMed: 16618605]  [MGI Ref ID J:113350]

Takai A; Marusawa H; Minaki Y; Watanabe T; Nakase H; Kinoshita K; Tsujimoto G; Chiba T. 2012. Targeting activation-induced cytidine deaminase prevents colon cancer development despite persistent colonic inflammation. Oncogene 31(13):1733-42. [PubMed: 21841819]  [MGI Ref ID J:186149]

Takiishi T; Tadokoro CE; Rizzo LV; de Moraes LV. 2012. Early IL-10 production is essential for syngeneic graft acceptance. J Leukoc Biol 92(2):259-64. [PubMed: 22416256]  [MGI Ref ID J:186218]

Tanikawa T; Wilke CM; Kryczek I; Chen GY; Kao J; Nunez G; Zou W. 2012. Interleukin-10 ablation promotes tumor development, growth, and metastasis. Cancer Res 72(2):420-9. [PubMed: 22123924]  [MGI Ref ID J:181148]

Tarrant TK; Silver PB; Wahlsten JL; Rizzo LV; Chan CC; Wiggert B; Caspi RR. 1999. Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon gamma, nitric oxide, and apoptosis. J Exp Med 189(2):219-30. [PubMed: 9892605]  [MGI Ref ID J:119614]

Tavares D; Ferreira P; Arala-Chaves M. 2000. Increased resistance to systemic candidiasis in athymic or interleukin-10-depleted mice. J Infect Dis 182(1):266-73. [PubMed: 10882606]  [MGI Ref ID J:135875]

Tawara I; Sun Y; Liu C; Toubai T; Nieves E; Evers R; Alrubaie M; Mathewson N; Tamaki H; Reddy P. 2012. Donor- but not host-derived interleukin-10 contributes to the regulation of experimental graft-versus-host disease. J Leukoc Biol 91(4):667-75. [PubMed: 22262800]  [MGI Ref ID J:184092]

TeKippe M; Harrison DE; Chen J. 2003. Expansion of hematopoietic stem cell phenotype and activity in Trp53-null mice. Exp Hematol 31(6):521-7. [PubMed: 12829028]  [MGI Ref ID J:115677]

Tewari N; Kalkunte S; Murray DW; Sharma S. 2009. The water channel aquaporin 1 is a novel molecular target of polychlorinated biphenyls for in utero anomalies. J Biol Chem 284(22):15224-32. [PubMed: 19332547]  [MGI Ref ID J:150508]

Thackray AM; McKenzie AN; Klein MA; Lauder A; Bujdoso R. 2004. Accelerated prion disease in the absence of interleukin-10. J Virol 78(24):13697-707. [PubMed: 15564479]  [MGI Ref ID J:94220]

Thaxton JE; Nevers T; Lippe EO; Blois SM; Saito S; Sharma S. 2013. NKG2D Blockade Inhibits Poly(I:C)-Triggered Fetal Loss in Wild Type but Not in IL-10-/- Mice. J Immunol 190(7):3639-47. [PubMed: 23455498]  [MGI Ref ID J:194828]

Thaxton JE; Romero R; Sharma S. 2009. TLR9 activation coupled to IL-10 deficiency induces adverse pregnancy outcomes. J Immunol 183(2):1144-54. [PubMed: 19561095]  [MGI Ref ID J:151664]

Toller IM; Altmeyer M; Kohler E; Hottiger MO; Muller A. 2010. Inhibition of ADP ribosylation prevents and cures helicobacter-induced gastric preneoplasia. Cancer Res 70(14):5912-22. [PubMed: 20634404]  [MGI Ref ID J:162229]

Tolstanova G; Deng X; French SW; Lungo W; Paunovic B; Khomenko T; Ahluwalia A; Kaplan T; Dacosta-Iyer M; Tarnawski A; Szabo S; Sandor Z. 2012. Early endothelial damage and increased colonic vascular permeability in the development of experimental ulcerative colitis in rats and mice. Lab Invest 92(1):9-21. [PubMed: 21894149]  [MGI Ref ID J:180036]

Tomczak MF; Erdman SE; Davidson A; Wang YY; Nambiar PR; Rogers AB; Rickman B; Luchetti D; Fox JG; Horwitz BH. 2006. Inhibition of Helicobacter hepaticus-induced colitis by IL-10 requires the p50/p105 subunit of NF-kappa B. J Immunol 177(10):7332-9. [PubMed: 17082652]  [MGI Ref ID J:140612]

Tomczak MF; Gadjeva M; Wang YY; Brown K; Maroulakou I; Tsichlis PN; Erdman SE; Fox JG; Horwitz BH. 2006. Defective activation of ERK in macrophages lacking the p50/p105 subunit of NF-kappaB is responsible for elevated expression of IL-12 p40 observed after challenge with Helicobacter hepaticus. J Immunol 176(2):1244-51. [PubMed: 16394015]  [MGI Ref ID J:126439]

Tongren JE; Corran PH; Jarra W; Langhorne J; Riley EM. 2005. Epitope-specific regulation of immunoglobulin class switching in mice immunized with malarial merozoite surface proteins. Infect Immun 73(12):8119-29. [PubMed: 16299306]  [MGI Ref ID J:104297]

Tosello Boari J; Amezcua Vesely MC; Bermejo DA; Ramello MC; Montes CL; Cejas H; Gruppi A; Acosta Rodriguez EV. 2012. IL-17RA signaling reduces inflammation and mortality during Trypanosoma cruzi infection by recruiting suppressive IL-10-producing neutrophils. PLoS Pathog 8(4):e1002658. [PubMed: 22577359]  [MGI Ref ID J:195387]

Toth LA; Opp MR. 2001. Cytokine- and microbially induced sleep responses of interleukin-10 deficient mice. Am J Physiol Regul Integr Comp Physiol 280(6):R1806-14. [PubMed: 11353686]  [MGI Ref ID J:114404]

Toto P; Feliciani C; Amerio P; Suzuki H; Wang B; Shivji GM; Woodley D; Sauder DN. 2000. Immune modulation in pemphigus vulgaris: role of CD28 and IL-10. J Immunol 164(1):522-9. [PubMed: 10605050]  [MGI Ref ID J:125983]

Tourneur L; Damotte D; Marion S; Mistou S; Chiocchia G. 2002. IL-10 is necessary for FasL-induced protection from experimental autoimmune thyroiditis but not for FasL-induced immune deviation. Eur J Immunol 32(5):1292-9. [PubMed: 11981816]  [MGI Ref ID J:76540]

Tournoy KG; Kips JC; Pauwels RA. 2001. Counterbalancing of TH2-driven allergic airway inflammation by IL-12 does not require IL-10. J Allergy Clin Immunol 107(3):483-91. [PubMed: 11240949]  [MGI Ref ID J:106293]

Trandem K; Zhao J; Fleming E; Perlman S. 2011. Highly activated cytotoxic CD8 T cells express protective IL-10 at the peak of coronavirus-induced encephalitis. J Immunol 186(6):3642-52. [PubMed: 21317392]  [MGI Ref ID J:169759]

Tso VK; Sydora BC; Foshaug RR; Churchill TA; Doyle J; Slupsky CM; Fedorak RN. 2013. Metabolomic profiles are gender, disease and time specific in the interleukin-10 gene-deficient mouse model of inflammatory bowel disease. PLoS One 8(7):e67654. [PubMed: 23874435]  [MGI Ref ID J:204413]

Tu H; Juelich T; Smith EM; Tyring SK; Rady PL; Hughes TK Jr. 2003. Evidence for endogenous interleukin-10 during nociception. J Neuroimmunol 139(1-2):145-9. [PubMed: 12799032]  [MGI Ref ID J:119039]

Turner JK; Xu JL; Tapping RI. 2009. Substrains of 129 mice are resistant to Yersinia pestis KIM5: implications for interleukin-10-deficient mice. Infect Immun 77(1):367-73. [PubMed: 18955473]  [MGI Ref ID J:144076]

Ueda N; Kuki H; Kamimura D; Sawa S; Seino K; Tashiro T; Fushuku K; Taniguchi M; Hirano T; Murakami M. 2006. CD1d-restricted NKT cell activation enhanced homeostatic proliferation of CD8+ T cells in a manner dependent on IL-4. Int Immunol 18(9):1397-404. [PubMed: 16914507]  [MGI Ref ID J:113387]

Ueda Y; Kayama H; Jeon SG; Kusu T; Isaka Y; Rakugi H; Yamamoto M; Takeda K. 2010. Commensal microbiota induce LPS hyporesponsiveness in colonic macrophages via the production of IL-10. Int Immunol 22(12):953-62. [PubMed: 21051439]  [MGI Ref ID J:167353]

Ueno A; Cho S; Cheng L; Wang J; Hou S; Nakano H; Santamaria P; Yang Y. 2007. Transient upregulation of indoleamine 2,3-dioxygenase in dendritic cells by human chorionic gonadotropin downregulates autoimmune diabetes. Diabetes 56(6):1686-93. [PubMed: 17360980]  [MGI Ref ID J:126514]

Uhlig HH; Coombes J; Mottet C; Izcue A; Thompson C; Fanger A; Tannapfel A; Fontenot JD; Ramsdell F; Powrie F. 2006. Characterization of Foxp3+CD4+CD25+ and IL-10-secreting CD4+CD25+ T cells during cure of colitis. J Immunol 177(9):5852-60. [PubMed: 17056509]  [MGI Ref ID J:140535]

Van Gool F; Galli M; Gueydan C; Kruys V; Prevot PP; Bedalov A; Mostoslavsky R; Alt FW; De Smedt T; Leo O. 2009. Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner. Nat Med 15(2):206-10. [PubMed: 19151729]  [MGI Ref ID J:146526]

Van Hove CL; Maes T; Joos GF; Tournoy KG. 2007. Prolonged inhaled allergen exposure can induce persistent tolerance. Am J Respir Cell Mol Biol 36(5):573-84. [PubMed: 17218615]  [MGI Ref ID J:136611]

VanLith ML; Kohlgraf KG; Sivinski CL; Tempero RM; Hollingsworth MA. 2002. MUC1-specific anti-tumor responses: molecular requirements for CD4-mediated responses. Int Immunol 14(8):873-82. [PubMed: 12147624]  [MGI Ref ID J:113544]

Varadhachary AS; Monestier M; Salgame P. 2001. Reciprocal induction of IL-10 and IL-12 from macrophages by low-density lipoprotein and its oxidized forms. Cell Immunol 213(1):45-51. [PubMed: 11747355]  [MGI Ref ID J:115363]

Varma TK; Durham M; Murphey ED; Cui W; Huang Z; Lin CY; Toliver-Kinsky T; Sherwood ER. 2005. Endotoxin priming improves clearance of Pseudomonas aeruginosa in wild-type and interleukin-10 knockout mice. Infect Immun 73(11):7340-7. [PubMed: 16239532]  [MGI Ref ID J:104229]

Vasquez RE; Xin L; Soong L. 2008. Effects of CXCL10 on dendritic cell and CD4+ T-cell functions during Leishmania amazonensis infection. Infect Immun 76(1):161-9. [PubMed: 17998308]  [MGI Ref ID J:130175]

Verhasselt V; Milcent V; Cazareth J; Kanda A; Fleury S; Dombrowicz D; Glaichenhaus N; Julia V. 2008. Breast milk-mediated transfer of an antigen induces tolerance and protection from allergic asthma. Nat Med 14(2):170-5. [PubMed: 18223654]  [MGI Ref ID J:133564]

Verma SK; Krishnamurthy P; Barefield D; Singh N; Gupta R; Lambers E; Thal M; Mackie A; Hoxha E; Ramirez V; Qin G; Sadayappan S; Ghosh AK; Kishore R. 2012. Interleukin-10 treatment attenuates pressure overload-induced hypertrophic remodeling and improves heart function via signal transducers and activators of transcription 3-dependent inhibition of nuclear factor-kappaB. Circulation 126(4):418-29. [PubMed: 22705886]  [MGI Ref ID J:202207]

Vijay-Kumar M; Sanders CJ; Taylor RT; Kumar A; Aitken JD; Sitaraman SV; Neish AS; Uematsu S; Akira S; Williams IR; Gewirtz AT. 2007. Deletion of TLR5 results in spontaneous colitis in mice. J Clin Invest 117(12):3909-21. [PubMed: 18008007]  [MGI Ref ID J:130765]

Villarino AV; Artis D; Bezbradica JS; Miller O; Saris CJ; Joyce S; Hunter CA. 2008. IL-27R deficiency delays the onset of colitis and protects from helminth-induced pathology in a model of chronic IBD. Int Immunol 20(6):739-52. [PubMed: 18375937]  [MGI Ref ID J:136179]

Villegas EN; Wille U; Craig L; Linsley PS; Rennick DM; Peach R; Hunter CA. 2000. Blockade of costimulation prevents infection-induced immunopathology in interleukin-10-deficient mice. Infect Immun 68(5):2837-44. [PubMed: 10768980]  [MGI Ref ID J:61699]

Vishwakarma V; Pati NB; Chandel HS; Sahoo SS; Saha B; Suar M. 2012. Evaluation of Salmonella enterica serovar Typhimurium TTSS-2 deficient fur mutant as safe live-attenuated vaccine candidate for immunocompromised mice. PLoS One 7(12):e52043. [PubMed: 23284865]  [MGI Ref ID J:195626]

Walker WE; Goldstein DR. 2007. Neonatal B cells suppress innate toll-like receptor immune responses and modulate alloimmunity. J Immunol 179(3):1700-10. [PubMed: 17641036]  [MGI Ref ID J:149945]

Walsh KP; Brady MT; Finlay CM; Boon L; Mills KH. 2009. Infection with a helminth parasite attenuates autoimmunity through TGF-beta-mediated suppression of Th17 and Th1 responses. J Immunol 183(3):1577-86. [PubMed: 19587018]  [MGI Ref ID J:151701]

Wang B; Zhuang L; Fujisawa H; Shinder GA; Feliciani C; Shivji GM; Suzuki H; Amerio P; Toto P; Sauder DN. 1999. Enhanced epidermal Langerhans cell migration in IL-10 knockout mice. J Immunol 162(1):277-83. [PubMed: 9886396]  [MGI Ref ID J:51636]

Wang J; Cho S; Ueno A; Cheng L; Xu BY; Desrosiers MD; Shi Y; Yang Y. 2008. Ligand-dependent induction of noninflammatory dendritic cells by anergic invariant NKT cells minimizes autoimmune inflammation. J Immunol 181(4):2438-45. [PubMed: 18684934]  [MGI Ref ID J:140188]

Wang L; Gordon RA; Huynh L; Su X; Park Min KH; Han J; Arthur JS; Kalliolias GD; Ivashkiv LB. 2010. Indirect inhibition of Toll-like receptor and type I interferon responses by ITAM-coupled receptors and integrins. Immunity 32(4):518-30. [PubMed: 20362473]  [MGI Ref ID J:160755]

Wang Q; Fang CH; Hasselgren PO. 2001. Intestinal permeability is reduced and IL-10 levels are increased in septic IL-6 knockout mice. Am J Physiol Regul Integr Comp Physiol 281(3):R1013-23. [PubMed: 11507020]  [MGI Ref ID J:71507]

Wang RX; Yu CR; Dambuza IM; Mahdi RM; Dolinska MB; Sergeev YV; Wingfield PT; Kim SH; Egwuagu CE. 2014. Interleukin-35 induces regulatory B cells that suppress autoimmune disease. Nat Med 20(6):633-41. [PubMed: 24743305]  [MGI Ref ID J:213242]

Weaver BK; Bohn E; Judd BA; Gil MP; Schreiber RD. 2007. ABIN-3: a molecular basis for species divergence in interleukin-10-induced anti-inflammatory actions. Mol Cell Biol 27(13):4603-16. [PubMed: 17485448]  [MGI Ref ID J:122758]

Weiss KA; Christiaansen AF; Fulton RB; Meyerholz DK; Varga SM. 2011. Multiple CD4+ T cell subsets produce immunomodulatory IL-10 during respiratory syncytial virus infection. J Immunol 187(6):3145-54. [PubMed: 21844390]  [MGI Ref ID J:179242]

Whary MT; Danon SJ; Feng Y; Ge Z; Sundina N; Ng V; Taylor NS; Rogers AB; Fox JG. 2006. Rapid onset of ulcerative typhlocolitis in B6.129P2-IL10tm1Cgn (IL-10-/-) mice infected with Helicobacter trogontum is associated with decreased colonization by altered Schaedler's flora. Infect Immun 74(12):6615-23. [PubMed: 16982822]  [MGI Ref ID J:115918]

Whary MT; Taylor NS; Feng Y; Ge Z; Muthupalani S; Versalovic J; Fox JG. 2011. Lactobacillus reuteri promotes Helicobacter hepaticus-associated typhlocolitis in gnotobiotic B6.129P2-IL-10(tm1Cgn) (IL-10(-/-) ) mice. Immunology 133(2):165-78. [PubMed: 21426337]  [MGI Ref ID J:173794]

White CA; Johansson M; Roberts CT; Ramsay AJ; Robertson SA. 2004. Effect of interleukin-10 null mutation on maternal immune response and reproductive outcome in mice. Biol Reprod 70(1):123-31. [PubMed: 13679317]  [MGI Ref ID J:89857]

Wilson EH; Wille-Reece U; Dzierszinski F; Hunter CA. 2005. A critical role for IL-10 in limiting inflammation during toxoplasmic encephalitis. J Neuroimmunol 165(1-2):63-74. [PubMed: 16005735]  [MGI Ref ID J:112764]

Wilson MS; Elnekave E; Mentink-Kane MM; Hodges MG; Pesce JT; Ramalingam TR; Thompson RW; Kamanaka M; Flavell RA; Keane-Myers A; Cheever AW; Wynn TA. 2007. IL-13Ralpha2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in mice. J Clin Invest 117(10):2941-51. [PubMed: 17885690]  [MGI Ref ID J:127527]

Wilson MS; Taylor MD; Balic A; Finney CA; Lamb JR; Maizels RM. 2005. Suppression of allergic airway inflammation by helminth-induced regulatory T cells. J Exp Med 202(9):1199-212. [PubMed: 16275759]  [MGI Ref ID J:118754]

Winer S; Chan Y; Paltser G; Truong D; Tsui H; Bahrami J; Dorfman R; Wang Y; Zielenski J; Mastronardi F; Maezawa Y; Drucker DJ; Engleman E; Winer D; Dosch HM. 2009. Normalization of obesity-associated insulin resistance through immunotherapy. Nat Med 15(8):921-9. [PubMed: 19633657]  [MGI Ref ID J:152185]

Winstead CJ; Reilly CS; Moon JJ; Jenkins MK; Hamilton SE; Jameson SC; Way SS; Khoruts A. 2010. CD4(+)CD25(+)Foxp3(+) regulatory T cells optimize diversity of the conventional T cell repertoire during reconstitution from lymphopenia. J Immunol 184(9):4749-60. [PubMed: 20357265]  [MGI Ref ID J:160453]

Wittig BM; Johansson B; Zoller M; Schwarzler C; Gunthert U. 2000. Abrogation of experimental colitis correlates with increased apoptosis in mice deficient for CD44 variant exon 7 (CD44v7). J Exp Med 191(12):2053-64. [PubMed: 10859330]  [MGI Ref ID J:62867]

Wohlleben G; Trujillo C; Muller J; Ritze Y; Grunewald S; Tatsch U; Erb KJ. 2004. Helminth infection modulates the development of allergen-induced airway inflammation. Int Immunol 16(4):585-96. [PubMed: 15039389]  [MGI Ref ID J:89202]

Wojciechowski W; Harris DP; Sprague F; Mousseau B; Makris M; Kusser K; Honjo T; Mohrs K; Mohrs M; Randall T; Lund FE. 2009. Cytokine-producing effector B cells regulate type 2 immunity to H. polygyrus. Immunity 30(3):421-33. [PubMed: 19249230]  [MGI Ref ID J:146768]

Wolfe DN; Karanikas AT; Hester SE; Kennett MJ; Harvill ET. 2010. IL-10 induction by Bordetella parapertussis limits a protective IFN-gamma response. J Immunol 184(3):1392-400. [PubMed: 20042578]  [MGI Ref ID J:159527]

Wu R; Li Y; Guo Z; Gong J; Zhu W; Li N; Li J. 2013. Triptolide ameliorates ileocolonic anastomosis inflammation in IL-10 deficient mice by mechanism involving suppression of miR-155/SHIP-1 signaling pathway. Mol Immunol 56(4):340-6. [PubMed: 23911388]  [MGI Ref ID J:202099]

Wynn TA; Cheever AW; Williams ME; Hieny S; Caspar P; Kuhn R; Muller W; Sher A. 1998. IL-10 regulates liver pathology in acute murine Schistosomiasis mansoni but is not required for immune down-modulation of chronic disease. J Immunol 160(9):4473-80. [PubMed: 9574553]  [MGI Ref ID J:119887]

Wynn TA; Morawetz R; Scharton-Kersten T; Hieny S; Morse HC 3rd ; Kuhn R ; Muller W ; Cheever AW ; Sher A. 1997. Analysis of granuloma formation in double cytokine-deficient mice reveals a central role for IL-10 in polarizing both T helper cell 1- and T helper cell 2-type cytokine responses in vivo. J Immunol 159(10):5014-23. [PubMed: 9366429]  [MGI Ref ID J:44069]

Xavier MN; Winter MG; Spees AM; Nguyen K; Atluri VL; Silva TM; Baumler AJ; Muller W; Santos RL; Tsolis RM. 2013. CD4+ T cell-derived IL-10 promotes Brucella abortus persistence via modulation of macrophage function. PLoS Pathog 9(6):e1003454. [PubMed: 23818855]  [MGI Ref ID J:213384]

Xia ZW; Xu LQ; Zhong WW; Wei JJ; Li NL; Shao J; Li YZ; Yu SC; Zhang ZL. 2007. Heme oxygenase-1 attenuates ovalbumin-induced airway inflammation by up-regulation of foxp3 T-regulatory cells, interleukin-10, and membrane-bound transforming growth factor- 1. Am J Pathol 171(6):1904-14. [PubMed: 17991714]  [MGI Ref ID J:129098]

Xu L; Yin W; Sun R; Wei H; Tian Z. 2013. Liver type I regulatory T cells suppress germinal center formation in HBV-tolerant mice. Proc Natl Acad Sci U S A 110(42):16993-8. [PubMed: 24089450]  [MGI Ref ID J:201989]

Xue X; Feng T; Yao S; Wolf KJ; Liu CG; Liu X; Elson CO; Cong Y. 2011. Microbiota downregulates dendritic cell expression of miR-10a, which targets IL-12/IL-23p40. J Immunol 187(11):5879-86. [PubMed: 22068236]  [MGI Ref ID J:179678]

Yan F; John SK; Wilson G; Jones DS; Washington MK; Polk DB. 2004. Kinase suppressor of Ras-1 protects intestinal epithelium from cytokine-mediated apoptosis during inflammation. J Clin Invest 114(9):1272-80. [PubMed: 15520859]  [MGI Ref ID J:94534]

Yanaba K; Bouaziz JD; Haas KM; Poe JC; Fujimoto M; Tedder TF. 2008. A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses. Immunity 28(5):639-50. [PubMed: 18482568]  [MGI Ref ID J:136340]

Yanaba K; Bouaziz JD; Matsushita T; Tsubata T; Tedder TF. 2009. The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals. J Immunol 182(12):7459-72. [PubMed: 19494269]  [MGI Ref ID J:149301]

Yanaba K; Kamata M; Ishiura N; Shibata S; Asano Y; Tada Y; Sugaya M; Kadono T; Tedder TF; Sato S. 2013. Regulatory B cells suppress imiquimod-induced, psoriasis-like skin inflammation. J Leukoc Biol 94(4):563-73. [PubMed: 23630391]  [MGI Ref ID J:202646]

Yang F; Dong A; Mueller P; Caicedo J; Sutton AM; Odetunde J; Barrick CJ; Klyachkin YM; Abdel-Latif A; Smyth SS. 2012. Coronary artery remodeling in a model of left ventricular pressure overload is influenced by platelets and inflammatory cells. PLoS One 7(8):e40196. [PubMed: 22916095]  [MGI Ref ID J:190055]

Yang HT; Wang Y; Zhao X; Demissie E; Papoutsopoulou S; Mambole A; O'Garra A; Tomczak MF; Erdman SE; Fox JG; Ley SC; Horwitz BH. 2011. NF-(kappa)B1 inhibits TLR-induced IFN-(beta) production in macrophages through TPL-2-dependent ERK activation. J Immunol 186(4):1989-96. [PubMed: 21217011]  [MGI Ref ID J:169175]

Yang I; Eibach D; Kops F; Brenneke B; Woltemate S; Schulze J; Bleich A; Gruber AD; Muthupalani S; Fox JG; Josenhans C; Suerbaum S. 2013. Intestinal microbiota composition of interleukin-10 deficient C57BL/6J mice and susceptibility to Helicobacter hepaticus-induced colitis. PLoS One 8(8):e70783. [PubMed: 23951007]  [MGI Ref ID J:204929]

Yang M; Deng J; Liu Y; Ko KH; Wang X; Jiao Z; Wang S; Hua Z; Sun L; Srivastava G; Lau CS; Cao X; Lu L. 2012. IL-10-Producing Regulatory B10 Cells Ameliorate Collagen-Induced Arthritis via Suppressing Th17 Cell Generation. Am J Pathol 180(6):2375-85. [PubMed: 22538089]  [MGI Ref ID J:184805]

Yang M; Sun L; Wang S; Ko KH; Xu H; Zheng BJ; Cao X; Lu L. 2010. Novel function of B cell-activating factor in the induction of IL-10-producing regulatory B cells. J Immunol 184(7):3321-5. [PubMed: 20208006]  [MGI Ref ID J:160064]

Yang X; Wang S; Fan Y; Han X. 2000. IL-10 deficiency prevents IL-5 overproduction and eosinophilic inflammation in a murine model of asthma-like reaction. Eur J Immunol 30(2):382-91. [PubMed: 10671193]  [MGI Ref ID J:60381]

Yang Z; Zhang X; Darrah PA; Mosser DM. 2010. The Regulation of Th1 Responses by the p38 MAPK. J Immunol 185(10):6205-13. [PubMed: 20937847]  [MGI Ref ID J:165637]

Yao Y; Li W; Kaplan MH; Chang CH. 2005. Interleukin (IL)-4 inhibits IL-10 to promote IL-12 production by dendritic cells. J Exp Med 201(12):1899-903. [PubMed: 15967820]  [MGI Ref ID J:99206]

Yen D; Cheung J; Scheerens H; Poulet F; McClanahan T; McKenzie B; Kleinschek MA; Owyang A; Mattson J; Blumenschein W; Murphy E; Sathe M; Cua DJ; Kastelein RA; Rennick D. 2006. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J Clin Invest 116(5):1310-6. [PubMed: 16670770]  [MGI Ref ID J:108946]

Yin S; Wang H; Park O; Wei W; Shen J; Gao B. 2011. Enhanced Liver Regeneration in IL-10-Deficient Mice after Partial Hepatectomy via Stimulating Inflammatory Response and Activating Hepatocyte STAT3. Am J Pathol 178(4):1614-21. [PubMed: 21435447]  [MGI Ref ID J:169853]

Yin Z; Bahtiyar G; Zhang N; Liu L; Zhu P; Robert ME; McNiff J; Madaio MP; Craft J. 2002. IL-10 regulates murine lupus. J Immunol 169(4):2148-55. [PubMed: 12165544]  [MGI Ref ID J:78239]

Yoshizaki A; Miyagaki T; DiLillo DJ; Matsushita T; Horikawa M; Kountikov EI; Spolski R; Poe JC; Leonard WJ; Tedder TF. 2012. Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions. Nature 491(7423):264-8. [PubMed: 23064231]  [MGI Ref ID J:189218]

Young A; Linehan E; Hams E; O'Hara Hall AC; McClurg A; Johnston JA; Hunter CA; Fallon PG; Fitzgerald DC. 2012. Cutting edge: suppression of GM-CSF expression in murine and human T cells by IL-27. J Immunol 189(5):2079-83. [PubMed: 22837488]  [MGI Ref ID J:189868]

Zediak VP; Hunter CA. 2003. IL-10 fails to inhibit the production of IL-18 in response to inflammatory stimuli. Cytokine 21(2):84-90. [PubMed: 12670447]  [MGI Ref ID J:128186]

Zemse SM; Chiao CW; Hilgers RH; Webb RC. 2010. Interleukin-10 inhibits the in vivo and in vitro adverse effects of TNF-{alpha} on the endothelium of murine aorta. Am J Physiol Heart Circ Physiol :. [PubMed: 20639218]  [MGI Ref ID J:162772]

Zhang B; Maris CH; Foell J; Whitmire J; Niu L; Song J; Kwon BS; Vella AT; Ahmed R; Jacob J; Mittler RS. 2007. Immune suppression or enhancement by CD137 T cell costimulation during acute viral infection is time dependent. J Clin Invest 117(10):3029-41. [PubMed: 17853940]  [MGI Ref ID J:127406]

Zhang L; Yuan S; Cheng G; Guo B. 2011. Type I IFN promotes IL-10 production from T cells to suppress Th17 cells and Th17-associated autoimmune inflammation. PLoS One 6(12):e28432. [PubMed: 22163016]  [MGI Ref ID J:182267]

Zhang N; Schroppel B; Lal G; Jakubzick C; Mao X; Chen D; Yin N; Jessberger R; Ochando JC; Ding Y; Bromberg JS. 2009. Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response. Immunity 30(3):458-69. [PubMed: 19303390]  [MGI Ref ID J:147032]

Zhang R; Li Q; Chuang PY; Lu G; Liu R; Yang J; Peng L; Dai Y; Zheng Z; Qi CF; He JC; Xiong H. 2013. Regulation of pathogenic th17 cell differentiation by IL-10 in the development of glomerulonephritis. Am J Pathol 183(2):402-12. [PubMed: 23747510]  [MGI Ref ID J:198724]

Zhang R; Li Y; Beck PL; McCafferty DM. 2007. Toll-like receptor 4 regulates colitis-associated adenocarcinoma development in interleukin-10-deficient (IL-10(-/-)) mice. Biochem Soc Trans 35(Pt 5):1375-6. [PubMed: 17956355]  [MGI Ref ID J:131228]

Zhang R; Ma A; Urbanski SJ; McCafferty DM. 2007. Induction of inducible nitric oxide synthase: a protective mechanism in colitis-induced adenocarcinoma. Carcinogenesis 28(5):1122-30. [PubMed: 17116728]  [MGI Ref ID J:121056]

Zhang X; Deriaud E; Jiao X; Braun D; Leclerc C; Lo-Man R. 2007. Type I interferons protect neonates from acute inflammation through interleukin 10-producing B cells. J Exp Med 204(5):1107-18. [PubMed: 17485512]  [MGI Ref ID J:125728]

Zhang X; Hester SE; Kennett MJ; Karanikas AT; Bendor L; Place DE; Harvill ET. 2011. Interleukin-1 receptor signaling is required to overcome the effects of pertussis toxin and for efficient infection- or vaccination-induced immunity against Bordetella pertussis. Infect Immun 79(1):527-41. [PubMed: 20974829]  [MGI Ref ID J:167554]

Zhao J; de Vera J; Narushima S; Beck EX; Palencia S; Shinkawa P; Kim KA; Liu Y; Levy MD; Berg DJ; Abo A; Funk WD. 2007. R-spondin1, a novel intestinotrophic mitogen, ameliorates experimental colitis in mice. Gastroenterology 132(4):1331-43. [PubMed: 17408649]  [MGI Ref ID J:203619]

Zhao Z; Ciric B; Yu S; Zhang GX; Rostami A. 2010. Targeting ganglioside epitope 3G11 on the surface of CD4+ T cells suppresses EAE by altering the Treg/Th17 cell balance. Int Immunol 22(10):817-26. [PubMed: 20679513]  [MGI Ref ID J:164321]

Zhong J; Deaciuc IV; Burikhanov R; de Villiers WJ. 2006. Lipopolysaccharide-induced liver apoptosis is increased in interleukin-10 knockout mice. Biochim Biophys Acta 1762(4):468-77. [PubMed: 16497487]  [MGI Ref ID J:110238]

Zhong Y; Cantwell A; Dube PH. 2010. Transforming growth factor beta and CD25 are important for controlling systemic dissemination following Yersinia enterocolitica infection of the gut. Infect Immun 78(9):3716-25. [PubMed: 20584975]  [MGI Ref ID J:163014]

Zhou D; Collins CA; Wu P; Brown EJ. 2010. Protein tyrosine phosphatase SHP-1 positively regulates TLR-induced IL-12p40 production in macrophages through inhibition of phosphatidylinositol 3-kinase. J Leukoc Biol 87(5):845-55. [PubMed: 20145200]  [MGI Ref ID J:160352]

Zhou F; Ciric B; Li H; Yan Y; Li K; Cullimore M; Lauretti E; Gonnella P; Zhang GX; Rostami A. 2012. IL-10 deficiency blocks the ability of LPS to regulate expression of tolerance-related molecules on dendritic cells. Eur J Immunol 42(6):1449-58. [PubMed: 22622800]  [MGI Ref ID J:187763]

Zhou P; Streutker C; Borojevic R; Wang Y; Croitoru K. 2004. IL-10 modulates intestinal damage and epithelial cell apoptosis in T cell-mediated enteropathy. Am J Physiol Gastrointest Liver Physiol 287(3):G599-604. [PubMed: 15331352]  [MGI Ref ID J:96079]

Zhu Y; Mahon BD; Froicu M; Cantorna MT. 2005. Calcium and 1 alpha,25-dihydroxyvitamin D3 target the TNF-alpha pathway to suppress experimental inflammatory bowel disease. Eur J Immunol 35(1):217-24. [PubMed: 15593122]  [MGI Ref ID J:95228]

Zimmermann S; Murray PJ; Heeg K; Dalpke AH. 2006. Induction of suppressor of cytokine signaling-1 by Toxoplasma gondii contributes to immune evasion in macrophages by blocking IFN-gamma signaling. J Immunol 176(3):1840-7. [PubMed: 16424215]  [MGI Ref ID J:126418]

Zohar Y; Wildbaum G; Novak R; Salzman AL; Thelen M; Alon R; Barsheshet Y; Karp CL; Karin N. 2014. CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis. J Clin Invest 124(5):2009-22. [PubMed: 24713654]  [MGI Ref ID J:212764]

Zou Q; Wu B; Xue J; Fan X; Feng C; Geng S; Wang M; Wang B. 2014. CD8+ Treg cells suppress CD8+ T cell-responses by IL-10-dependent mechanism during H5N1 influenza virus infection. Eur J Immunol 44(1):103-14. [PubMed: 24114149]  [MGI Ref ID J:208656]

de Buhr MF; Hedrich HJ; Westendorf AM; Obermeier F; Hofmann C; Zschemisch NH; Buer J; Bumann D; Goyert SM; Bleich A. 2009. Analysis of Cd14 as a genetic modifier of experimental inflammatory bowel disease (IBD) in mice. Inflamm Bowel Dis 15(12):1824-1836. [PubMed: 19637338]  [MGI Ref ID J:154082]

de Koning BA; van Dieren JM; Lindenbergh-Kortleve DJ; van der Sluis M; Matsumoto T; Yamaguchi K; Einerhand AW; Samsom JN; Pieters R; Nieuwenhuis EE. 2006. Contributions of mucosal immune cells to methotrexate-induced mucositis. Int Immunol 18(6):941-9. [PubMed: 16636014]  [MGI Ref ID J:109135]

de Ledesma AM; Desai AN; Bolivar VJ; Symula DJ; Flaherty L. 2006. Two new behavioral QTLs, Emo4 and Reb1, map to mouse Chromosome 1: Congenic strains and candidate gene identification studies. Mamm Genome 17(2):111-8. [PubMed: 16465591]  [MGI Ref ID J:105315]

den Boer MA; Voshol PJ; Schroder-van der Elst JP; Korsheninnikova E; Ouwens DM; Kuipers F; Havekes LM; Romijn JA. 2006. Endogenous interleukin-10 protects against hepatic steatosis but does not improve insulin sensitivity during high-fat feeding in mice. Endocrinology 147(10):4553-8. [PubMed: 16709607]  [MGI Ref ID J:129479]

van Den Broek M; Bachmann MF; Kohler G; Barner M; Escher R; Zinkernagel R; Kopf M. 2000. IL-4 and IL-10 antagonize IL-12-mediated protection against acute vaccinia virus infection with a limited role of IFN-gamma and nitric oxide synthetase 2. J Immunol 164(1):371-8. [PubMed: 10605032]  [MGI Ref ID J:125984]

van der Sluis M; Bouma J; Vincent A; Velcich A; Carraway KL; Buller HA; Einerhand AW; van Goudoever JB; Van Seuningen I; Renes IB. 2008. Combined defects in epithelial and immunoregulatory factors exacerbate the pathogenesis of inflammation: mucin 2-interleukin 10-deficient mice. Lab Invest 88(6):634-42. [PubMed: 18427556]  [MGI Ref ID J:136253]

Pde6brd1 related

Acosta ML; Fletcher EL; Azizoglu S; Foster LE; Farber DB; Kalloniatis M. 2005. Early markers of retinal degeneration in rd/rd mice. Mol Vis 11:717-28. [PubMed: 16163270]  [MGI Ref ID J:103970]

Aftab U; Jiang C; Tucker B; Kim JY; Klassen H; Miljan E; Sinden J; Young M. 2009. Growth kinetics and transplantation of human retinal progenitor cells. Exp Eye Res 89(3):301-10. [PubMed: 19524569]  [MGI Ref ID J:151412]

Ahuja S; Ahuja-Jensen P; Johnson LE; Caffe AR; Abrahamson M; Ekstrom PA; van Veen T. 2008. rd1 Mouse retina shows an imbalance in the activity of cysteine protease cathepsins and their endogenous inhibitor cystatin C. Invest Ophthalmol Vis Sci 49(3):1089-96. [PubMed: 18326735]  [MGI Ref ID J:133024]

Ahuja-Jensen P; Johnsen-Soriano S; Ahuja S; Bosch-Morell F; Sancho-Tello M; Romero FJ; Abrahamson M; van Veen T. 2007. Low glutathione peroxidase in rd1 mouse retina increases oxidative stress and proteases. Neuroreport 18(8):797-801. [PubMed: 17471069]  [MGI Ref ID J:122802]

Alavi MV; Bette S; Schimpf S; Schuettauf F; Schraermeyer U; Wehrl HF; Ruttiger L; Beck SC; Tonagel F; Pichler BJ; Knipper M; Peters T; Laufs J; Wissinger B. 2007. A splice site mutation in the murine Opa1 gene features pathology of autosomal dominant optic atrophy. Brain 130(Pt 4):1029-42. [PubMed: 17314202]  [MGI Ref ID J:154966]

Allen AE; Brown TM; Lucas RJ. 2011. A distinct contribution of short-wavelength-sensitive cones to light-evoked activity in the mouse pretectal olivary nucleus. J Neurosci 31(46):16833-43. [PubMed: 22090509]  [MGI Ref ID J:177906]

Allen AE; Cameron MA; Brown TM; Vugler AA; Lucas RJ. 2010. Visual responses in mice lacking critical components of all known retinal phototransduction cascades. PLoS One 5(11):e15063. [PubMed: 21124780]  [MGI Ref ID J:167121]

Alvarez-Lopez C; Cernuda-Cernuda R; Alcorta E; Alvarez-Viejo M; Manuel Garcia-Fernandez J. 2004. Altered endogenous activation of CREB in the suprachiasmatic nucleus of mice with retinal degeneration. Brain Res 1024(1-2):137-45. [PubMed: 15451375]  [MGI Ref ID J:92980]

Alvarez-Lopez C; Cernuda-Cernuda R; Garcia-Fernandez JM. 2006. The mPer1 clock gene expression in the rd mouse suprachiasmatic nucleus is affected by the retinal degeneration. Brain Res 1087(1):134-41. [PubMed: 16626665]  [MGI Ref ID J:109668]

Alvarez-Lopez C; Cernuda-Cernuda R; Paniagua MA; Alvarez-Viejo M; Fernandez-Lopez A; Garcia-Fernandez JM. 2004. The transcription factor CREB is phosphorylated in neurons of the piriform cortex of blind mice in response to illumination of the retina. Neurosci Lett 357(3):223-6. [PubMed: 15003290]  [MGI Ref ID J:121036]

Ardayfio P; Moon J; Leung KK; Youn-Hwang D; Kim KS. 2008. Impaired learning and memory in Pitx3 deficient aphakia mice: A genetic model for striatum-dependent cognitive symptoms in Parkinson's disease. Neurobiol Dis :. [PubMed: 18573342]  [MGI Ref ID J:136304]

Ash J; McLeod DS; Lutty GA. 2005. Transgenic expression of leukemia inhibitory factor (LIF) blocks normal vascular development but not pathological neovascularization in the eye. Mol Vis 11:298-308. [PubMed: 15889014]  [MGI Ref ID J:98579]

Ash JA; Velazquez R; Kelley CM; Powers BE; Ginsberg SD; Mufson EJ; Strupp BJ. 2014. Maternal choline supplementation improves spatial mapping and increases basal forebrain cholinergic neuron number and size in aged Ts65Dn mice. Neurobiol Dis 70:32-42. [PubMed: 24932939]  [MGI Ref ID J:218355]

Audo I; Bujakowska K; Orhan E; Poloschek CM; Defoort-Dhellemmes S; Drumare I; Kohl S; Luu TD; Lecompte O; Zrenner E; Lancelot ME; Antonio A; Germain A; Michiels C; Audier C; Letexier M; Saraiva JP; Leroy BP; Munier FL; Mohand-Said S; Lorenz B; Friedburg C; Preising M; Kellner U; Renner AB; Moskova-Doumanova V; Berger W; Wissinger B; Hamel CP; Schorderet DF; De Baere E; Sharon D; Banin E; Jacobson SG; Bonneau D; Zanlonghi X; Le Meur G; Casteels I; Koenekoop R; Long VW; Meire F; Prescott K; de Ravel T; Simm. 2012. Whole-exome sequencing identifies mutations in GPR179 leading to autosomal-recessive complete congenital stationary night blindness. Am J Hum Genet 90(2):321-30. [PubMed: 22325361]  [MGI Ref ID J:196741]

Azadi S; Paquet-Durand F; Medstrand P; van Veen T; Ekstrom PA. 2006. Up-regulation and increased phosphorylation of protein kinase C (PKC) delta, mu and theta in the degenerating rd1 mouse retina. Mol Cell Neurosci 31(4):759-73. [PubMed: 16503160]  [MGI Ref ID J:108601]

BRUCKNER R. 1951. [Slit-lamp microscopy and ophthalmoscopy in rat and mouse.] Doc Ophthalmol 5-6:452-554. [PubMed: 14896883]  [MGI Ref ID J:25576]

Ball SL; Powers PA; Shin HS; Morgans CW; Peachey NS; Gregg RG. 2002. Role of the beta(2) subunit of voltage-dependent calcium channels in the retinal outer plexiform layer. Invest Ophthalmol Vis Sci 43(5):1595-603. [PubMed: 11980879]  [MGI Ref ID J:80080]

Barabas P; Liu A; Xing W; Chen CK; Tong Z; Watt CB; Jones BW; Bernstein PS; Krizaj D. 2013. Role of ELOVL4 and very long-chain polyunsaturated fatty acids in mouse models of Stargardt type 3 retinal degeneration. Proc Natl Acad Sci U S A 110(13):5181-6. [PubMed: 23479632]  [MGI Ref ID J:194246]

Barber AC; Hippert C; Duran Y; West EL; Bainbridge JW; Warre-Cornish K; Luhmann UF; Lakowski J; Sowden JC; Ali RR; Pearson RA. 2013. Repair of the degenerate retina by photoreceptor transplantation. Proc Natl Acad Sci U S A 110(1):354-9. [PubMed: 23248312]  [MGI Ref ID J:192521]

Bi A; Cui J; Ma YP; Olshevskaya E; Pu M; Dizhoor AM; Pan ZH. 2006. Ectopic expression of a microbial-type rhodopsin restores visual responses in mice with photoreceptor degeneration. Neuron 50(1):23-33. [PubMed: 16600853]  [MGI Ref ID J:122947]

Blanks JC; Bok D. 1977. An autoradiographic analysis of postnatal cell proliferation in the normal and degenerative mouse retina. J Comp Neurol 174(2):317-27. [PubMed: 864040]  [MGI Ref ID J:5812]

Borowska J; Trenholm S; Awatramani GB. 2011. An intrinsic neural oscillator in the degenerating mouse retina. J Neurosci 31(13):5000-12. [PubMed: 21451038]  [MGI Ref ID J:171202]

Bowes C; Danciger M; Kozak CA; Farber DB. 1989. Isolation of a candidate cDNA for the gene causing retinal degeneration in the rd mouse [published erratum appears in Proc Natl Acad Sci U S A 1990 Feb;87(4):1625] Proc Natl Acad Sci U S A 86(24):9722-6. [PubMed: 2481314]  [MGI Ref ID J:10184]

Bowes C; Li T; Danciger M; Baxter LC; Applebury ML; Farber DB. 1990. Retinal degeneration in the rd mouse is caused by a defect in the beta subunit of rod cGMP-phosphodiesterase [see comments] Nature 347(6294):677-80. [PubMed: 1977087]  [MGI Ref ID J:10777]

Bowes C; Li T; Frankel WN; Danciger M; Coffin JM; Applebury ML; Farber DB. 1993. Localization of a retroviral element within the rd gene coding for the beta subunit of cGMP phosphodiesterase. Proc Natl Acad Sci U S A 90(7):2955-9. [PubMed: 8385352]  [MGI Ref ID J:4366]

Bramall AN; Szego MJ; Pacione LR; Chang I; Diez E; D'Orleans-Juste P; Stewart DJ; Hauswirth WW; Yanagisawa M; McInnes RR. 2013. Endothelin-2-mediated protection of mutant photoreceptors in inherited photoreceptor degeneration. PLoS One 8(2):e58023. [PubMed: 23469133]  [MGI Ref ID J:198395]

Brown TM; Gias C; Hatori M; Keding SR; Semo M; Coffey PJ; Gigg J; Piggins HD; Panda S; Lucas RJ. 2010. Melanopsin contributions to irradiance coding in the thalamo-cortical visual system. PLoS Biol 8(12):e1000558. [PubMed: 21151887]  [MGI Ref ID J:170401]

Buhr ED; Van Gelder RN. 2014. Local photic entrainment of the retinal circadian oscillator in the absence of rods, cones, and melanopsin. Proc Natl Acad Sci U S A 111(23):8625-30. [PubMed: 24843129]  [MGI Ref ID J:211359]

Bumsted KM; Rizzolo LJ; Barnstable CJ. 2001. Defects in the MITF(mi/mi) apical surface are associated with a failure of outer segment elongation. Exp Eye Res 73(3):383-92. [PubMed: 11520113]  [MGI Ref ID J:115620]

Busskamp V; Duebel J; Balya D; Fradot M; Viney TJ; Siegert S; Groner AC; Cabuy E; Forster V; Seeliger M; Biel M; Humphries P; Paques M; Mohand-Said S; Trono D; Deisseroth K; Sahel JA; Picaud S; Roska B. 2010. Genetic reactivation of cone photoreceptors restores visual responses in retinitis pigmentosa. Science 329(5990):413-7. [PubMed: 20576849]  [MGI Ref ID J:162017]

Caley DW; Johnson C; Liebelt RA. 1972. The postnatal development of the retina in the normal and rodless CBA mouse: a light and electron microscopic study. Am J Anat 133(2):179-212. [PubMed: 5009246]  [MGI Ref ID J:5250]

Cameron MA; Pozdeyev N; Vugler AA; Cooper H; Iuvone PM; Lucas RJ. 2009. Light regulation of retinal dopamine that is independent of melanopsin phototransduction. Eur J Neurosci 29(4):761-7. [PubMed: 19200071]  [MGI Ref ID J:146469]

Carter-Dawson LD; LaVail MM; Sidman RL. 1978. Differential effect of the rd mutation on rods and cones in the mouse retina. Invest Ophthalmol Vis Sci 17(6):489-98. [PubMed: 659071]  [MGI Ref ID J:5988]

Cayouette M; Gravel C. 1997. Adenovirus-mediated gene transfer of ciliary neurotrophic factor can prevent photoreceptor degeneration in the retinal degeneration (rd) mouse. Hum Gene Ther 8(4):423-30. [PubMed: 9054517]  [MGI Ref ID J:39262]

Cayouette M; Smith SB; Becerra SP; Gravel C. 1999. Pigment epithelium-derived factor delays the death of photoreceptors in mouse models of inherited retinal degenerations. Neurobiol Dis 6(6):523-32. [PubMed: 10600408]  [MGI Ref ID J:59343]

Chang B; Hawes NL; Hurd RE; Davisson MT; Nusinowitz S; Heckenlively JR. 2002. Retinal degeneration mutants in the mouse. Vision Res 42(4):517-25. [PubMed: 11853768]  [MGI Ref ID J:75095]

Chang B; Hawes NL; Hurd RE; Wang J; Howell D; Davisson MT; Roderick TH; Nusinowitz S; Heckenlively JR. 2005. Mouse models of ocular diseases. Vis Neurosci 22(5):587-93. [PubMed: 16332269]  [MGI Ref ID J:156373]

Chang B; Hurd R; Wang J; Nishina P. 2013. Survey of common eye diseases in laboratory mouse strains. Invest Ophthalmol Vis Sci 54(7):4974-81. [PubMed: 23800770]  [MGI Ref ID J:198916]

Charbel Issa P; Singh MS; Lipinski DM; Chong NV; Delori FC; Barnard AR; MacLaren RE. 2012. Optimization of in vivo confocal autofluorescence imaging of the ocular fundus in mice and its application to models of human retinal degeneration. Invest Ophthalmol Vis Sci 53(2):1066-75. [PubMed: 22169101]  [MGI Ref ID J:191520]

Chen B; Cepko CL. 2009. HDAC4 regulates neuronal survival in normal and diseased retinas. Science 323(5911):256-9. [PubMed: 19131628]  [MGI Ref ID J:143166]

Chen Q; Khoury M; Chen J. 2009. Expression of human cytokines dramatically improves reconstitution of specific human-blood lineage cells in humanized mice. Proc Natl Acad Sci U S A :. [PubMed: 19966223]  [MGI Ref ID J:155817]

Chua J; Nivison-Smith L; Fletcher EL; Trenholm S; Awatramani GB; Kalloniatis M. 2013. Early remodeling of Muller cells in the rd/rd mouse model of retinal dystrophy. J Comp Neurol 521(11):2439-53. [PubMed: 23348616]  [MGI Ref ID J:200732]

Cohen AI; Blazynski C. 1990. Dopamine and its agonists reduce a light-sensitive pool of cyclic AMP in mouse photoreceptors. Vis Neurosci 4(1):43-52. [PubMed: 1702315]  [MGI Ref ID J:78184]

Cornett A; Sucic JF; Hillsburg D; Cyr L; Johnson C; Polanco A; Figuereo J; Cabine K; Russo N; Sturtevant A; Jarvinen MK. 2011. Altered glial gene expression, density, and architecture in the visual cortex upon retinal degeneration. Brain Res 1422:46-56. [PubMed: 21983206]  [MGI Ref ID J:179028]

Danciger M; Bowes C; Kozak CA; LaVail MM; Farber DB. 1990. Fine mapping of a putative rd cDNA and its co-segregation with rd expression. Invest Ophthalmol Vis Sci 31(8):1427-32. [PubMed: 1974892]  [MGI Ref ID J:10689]

Daniels DM; Stoddart CW; Martin-Iverson MT; Lai CM; Redmond TM; Rakoczy PE. 2003. Entrainment of circadian rhythm to a photoperiod reversal shows retinal dystrophy in RPE65(-/-) mice. Physiol Behav 79(4-5):701-11. [PubMed: 12954412]  [MGI Ref ID J:96439]

Davies VJ; Powell KA; White KE; Yip W; Hogan V; Hollins AJ; Davies JR; Piechota M; Brownstein DG; Moat SJ; Nichols PP; Wride MA; Boulton ME; Votruba M. 2008. A missense mutation in the murine Opa3 gene models human Costeff syndrome. Brain 131(Pt 2):368-80. [PubMed: 18222992]  [MGI Ref ID J:181670]

Davis RJ; Tosi J; Janisch KM; Kasanuki JM; Wang NK; Kong J; Tsui I; Cilluffo M; Woodruff ML; Fain GL; Lin CS; Tsang SH. 2008. Functional rescue of degenerating photoreceptors in mice homozygous for a hypomorphic cGMP phosphodiesterase 6 b allele (Pde6bH620Q). Invest Ophthalmol Vis Sci 49(11):5067-76. [PubMed: 18658088]  [MGI Ref ID J:141984]

Del Rio P; Irmler M; Arango-Gonzalez B; Favor J; Bobe C; Bartsch U; Vecino E; Beckers J; Hauck SM; Ueffing M. 2011. GDNF-induced osteopontin from Muller glial cells promotes photoreceptor survival in the Pde6b(rd1) mouse model of retinal degeneration. Glia 59(5):821-32. [PubMed: 21360756]  [MGI Ref ID J:169746]

Delyfer MN; Forster V; Neveux N; Picaud S; Leveillard T; Sahel JA. 2005. Evidence for glutamate-mediated excitotoxic mechanisms during photoreceptor degeneration in the rd1 mouse retina. Mol Vis 11:688-96. [PubMed: 16163266]  [MGI Ref ID J:103968]

Demos C; Bandyopadhyay M; Rohrer B. 2008. Identification of candidate genes for human retinal degeneration loci using differentially expressed genes from mouse photoreceptor dystrophy models. Mol Vis 14:1639-49. [PubMed: 18776951]  [MGI Ref ID J:140115]

Doonan F; Donovan M; Cotter TG. 2003. Caspase-independent photoreceptor apoptosis in mouse models of retinal degeneration. J Neurosci 23(13):5723-31. [PubMed: 12843276]  [MGI Ref ID J:84389]

Drager UC; Hubel DH. 1978. Studies of visual function and its decay in mice with hereditary retinal degeneration. J Comp Neurol 180(1):85-114. [PubMed: 649791]  [MGI Ref ID J:5980]

Du Y; Davisson MT; Kafadar K; Gardiner K. 2006. A-to-I pre-mRNA editing of the serotonin 2C receptor: comparisons among inbred mouse strains. Gene 382:39-46. [PubMed: 16904273]  [MGI Ref ID J:115050]

Ekstrom P; Sanyal S; Narfstrom K; Chader GJ; van Veen T. 1988. Accumulation of glial fibrillary acidic protein in Muller radial glia during retinal degeneration. Invest Ophthalmol Vis Sci 29(9):1363-71. [PubMed: 3417421]  [MGI Ref ID J:27850]

Feng BS; He SH; Zheng PY; Wu L; Yang PC. 2007. Mast cells play a crucial role in Staphylococcus aureus peptidoglycan-induced diarrhea. Am J Pathol 171(2):537-47. [PubMed: 17600127]  [MGI Ref ID J:123928]

Fletcher RT; Sanyal S; Krishna G; Aguirre G; Chader GJ. 1986. Genetic expression of cyclic GMP phosphodiesterase activity defines abnormal photoreceptor differentiation in neurological mutants of inherited retinal degeneration. J Neurochem 46(4):1240-5. [PubMed: 3005510]  [MGI Ref ID J:12044]

Foster RG; Argamaso S; Coleman S; Colwell CS; Lederman A; Provencio I. 1993. Photoreceptors regulating circadian behavior: a mouse model. J Biol Rhythms 8 Suppl:S17-23. [PubMed: 8274758]  [MGI Ref ID J:17940]

Foster RG; Provencio I; Hudson D; Fiske S; De Grip W; Menaker M. 1991. Circadian photoreception in the retinally degenerate mouse (rd/rd). J Comp Physiol [A] 169(1):39-50. [PubMed: 1941717]  [MGI Ref ID J:83743]

Frasson M; Picaud S; Leveillard T; Simonutti M; Mohand-Said S; Dreyfus H; Hicks D; Sabel J. 1999. Glial cell line-derived neurotrophic factor induces histologic and functional protection of rod photoreceptors in the rd/rd mouse. Invest Ophthalmol Vis Sci 40(11):2724-34. [PubMed: 10509671]  [MGI Ref ID J:57866]

Frasson M; Sahel JA; Fabre M; Simonutti M; Dreyfus H; Picaud S. 1999. Retinitis pigmentosa: rod photoreceptor rescue by a calcium-channel blocker in the rd mouse. Nat Med 5(10):1183-7. [PubMed: 10502823]  [MGI Ref ID J:57986]

Gao H; Hollyfield JG. 1995. Basic fibroblast growth factor in retinal development: differential levels of bFGF expression and content in normal and retinal degeneration (rd) mutant mice. Dev Biol 169(1):168-184. [PubMed: 7750636]  [MGI Ref ID J:25273]

Garcia-Fernandez JM; Jimenez AJ; Foster RG. 1995. The persistence of cone photoreceptors within the dorsal retina of aged retinally degenerate mice (rd/rd): implications for circadian organization. Neurosci Lett 187(1):33-6. [PubMed: 7617296]  [MGI Ref ID J:25157]

Gaub BM; Berry MH; Holt AE; Reiner A; Kienzler MA; Dolgova N; Nikonov S; Aguirre GD; Beltran WA; Flannery JG; Isacoff EY. 2014. Restoration of visual function by expression of a light-gated mammalian ion channel in retinal ganglion cells or ON-bipolar cells. Proc Natl Acad Sci U S A 111(51):E5574-83. [PubMed: 25489083]  [MGI Ref ID J:216941]

Gimenez E; Montoliu L. 2001. A simple polymerase chain reaction assay for genotyping the retinal degeneration mutation (Pdeb(rd1)) in FVB/N-derived transgenic mice. Lab Anim 35(2):153-6. [PubMed: 11315164]  [MGI Ref ID J:69558]

Goel M; Dhingra NK. 2012. Muller glia express rhodopsin in a mouse model of inherited retinal degeneration. Neuroscience 225:152-61. [PubMed: 22967839]  [MGI Ref ID J:192477]

Golub MS; Germann SL; Mercer M; Gordon MN; Morgan DG; Mayer LP; Hoyer PB. 2008. Behavioral consequences of ovarian atrophy and estrogen replacement in the APPswe mouse. Neurobiol Aging 29(10):1512-23. [PubMed: 17451844]  [MGI Ref ID J:140912]

Gouras P; Du J; Kjeldbye H; Kwun R; Lopez R; Zack DJ. 1991. Transplanted photoreceptors identified in dystrophic mouse retina by a transgenic reporter gene. Invest Ophthalmol Vis Sci 32(13):3167-74. [PubMed: 1748547]  [MGI Ref ID J:607]

Gouras P; Du J; Kjeldbye H; Yamamoto S; Zack DJ. 1994. Long-term photoreceptor transplants in dystrophic and normal mouse retina. Invest Ophthalmol Vis Sci 35(8):3145-53. [PubMed: 8045709]  [MGI Ref ID J:20769]

Grafstein B; Murray M; Ingoglia NA. 1972. Protein synthesis and axonal transport in retinal ganglion cells of mice lacking visual receptors. Brain Res 44(1):37-48. [PubMed: 4115728]  [MGI Ref ID J:5292]

Graham DR; Overbeek PA; Ash JD. 2005. Leukemia inhibitory factor blocks expression of crx and nrl transcription factors to inhibit photoreceptor differentiation. Invest Ophthalmol Vis Sci 46(7):2601-10. [PubMed: 15980254]  [MGI Ref ID J:99409]

Greferath U; Goh HC; Chua PY; Astrand E; O'Brien EE; Fletcher EL; Murphy M. 2009. Mapping retinal degeneration and loss-of-function in Rd-FTL mice. Invest Ophthalmol Vis Sci 50(12):5955-64. [PubMed: 19661224]  [MGI Ref ID J:158255]

Grimm C; Wenzel A; Stanescu D; Samardzija M; Hotop S; Groszer M; Naash M; Gassmann M; Reme C. 2004. Constitutive overexpression of human erythropoietin protects the mouse retina against induced but not inherited retinal degeneration. J Neurosci 24(25):5651-8. [PubMed: 15215287]  [MGI Ref ID J:133235]

Hackam AS; Strom R; Liu D; Qian J; Wang C; Otteson D; Gunatilaka T; Farkas RH; Chowers I; Kageyama M; Leveillard T; Sahel JA; Campochiaro PA; Parmigiani G; Zack DJ. 2004. Identification of gene expression changes associated with the progression of retinal degeneration in the rd1 mouse. Invest Ophthalmol Vis Sci 45(9):2929-42. [PubMed: 15326104]  [MGI Ref ID J:92921]

Hafezi F; Abegg M; Grimm C; Wenzel A; Munz K; Sturmer J; Farber DB; Reme CE. 1998. Retinal degeneration in the rd mouse in the absence of c-fos. Invest Ophthalmol Vis Sci 39(12):2239-44. [PubMed: 9804131]  [MGI Ref ID J:112088]

Hanno Y; Nakahira M; Jishage K; Noda T; Yoshihara Y. 2003. Tracking mouse visual pathways with WGA transgene. Eur J Neurosci 18(10):2910-4. [PubMed: 14656342]  [MGI Ref ID J:128266]

Hart AW; McKie L; Morgan JE; Gautier P; West K; Jackson IJ; Cross SH. 2005. Genotype-phenotype correlation of mouse pde6b mutations. Invest Ophthalmol Vis Sci 46(9):3443-50. [PubMed: 16123450]  [MGI Ref ID J:101336]

Hatori M; Le H; Vollmers C; Keding SR; Tanaka N; Schmedt C; Jegla T; Panda S. 2008. Inducible ablation of melanopsin-expressing retinal ganglion cells reveals their central role in non-image forming visual responses. PLoS ONE 3(6):e2451. [PubMed: 18545654]  [MGI Ref ID J:137151]

Hawes NL; Smith RS; Chang B; Davisson M; Heckenlively JR; John SW. 1999. Mouse fundus photography and angiography: a catalogue of normal and mutant phenotypes. Mol Vis 5:22. [PubMed: 10493779]  [MGI Ref ID J:59481]

Heckenlively JR; Chang B; Erway LC; Peng C; Hawes NL; Hageman GS; Roderick TH. 1995. Mouse model for Usher syndrome: linkage mapping suggests homology to Usher type I reported at human chromosome 11p15. Proc Natl Acad Sci U S A 92(24):11100-4. [PubMed: 7479945]  [MGI Ref ID J:121993]

Heynen SR; Tanimoto N; Joly S; Seeliger MW; Samardzija M; Grimm C. 2011. Retinal degeneration modulates intracellular localization of CDC42 in photoreceptors. Mol Vis 17:2934-46. [PubMed: 22128240]  [MGI Ref ID J:179662]

Hopp RM; Ransom N; Hilsenbeck SG; Papermaster DS; Windle JJ. 1998. Apoptosis in the murine rd1 retinal degeneration is predominantly p53-independent. Mol Vis 4:5. [PubMed: 9485488]  [MGI Ref ID J:47520]

Horev G; Benjamini Y; Sakov A; Golani I. 2007. Estimating wall guidance and attraction in mouse free locomotor behavior. Genes Brain Behav 6(1):30-41. [PubMed: 17233639]  [MGI Ref ID J:132656]

Hsiao FC; Liao YH; Tsai LL. 2013. Differential effects of retinal degeneration on sleep and wakefulness responses to short light-dark cycles in albino mice. Neuroscience 248C:459-468. [PubMed: 23811394]  [MGI Ref ID J:207054]

Huber G; Beck SC; Grimm C; Sahaboglu-Tekgoz A; Paquet-Durand F; Wenzel A; Humphries P; Redmond TM; Seeliger MW; Fischer MD. 2009. Spectral domain optical coherence tomography in mouse models of retinal degeneration. Invest Ophthalmol Vis Sci 50(12):5888-95. [PubMed: 19661229]  [MGI Ref ID J:158254]

Huerta JJ; Llamosas MM; Cernuda-Cernuda R; Garcia-Fernandez JM. 1997. Fos expression in the retina of rd/rd mice during the light/dark cycle. Neurosci Lett 232(3):143-6. [PubMed: 9310300]  [MGI Ref ID J:43873]

Huerta JJ; Llamosas MM; Cernuda-Cernuda R; Garcia-Fernandez JM. 1999. Spatio-temporal analysis of light-induced Fos expression in the retina of rd mutant mice. Brain Res 834(1-2):122-7. [PubMed: 10407100]  [MGI Ref ID J:56973]

Hughes S; Pothecary CA; Jagannath A; Foster RG; Hankins MW; Peirson SN. 2012. Profound defects in pupillary responses to light in TRPM-channel null mice: a role for TRPM channels in non-image-forming photoreception. Eur J Neurosci 35(1):34-43. [PubMed: 22211741]  [MGI Ref ID J:184336]

Hussain AA; Willmott NJ; Voaden MJ. 1992. Cyclic GMP, calcium and photoreceptor sensitivity in mice heterozygous for the rod dysplasia gene designated rd. Vision Res 32(1):29-36. [PubMed: 1323896]  [MGI Ref ID J:611]

Hwang DY; Fleming SM; Ardayfio P; Moran-Gates T; Kim H; Tarazi FI; Chesselet MF; Kim KS. 2005. 3,4-dihydroxyphenylalanine reverses the motor deficits in Pitx3-deficient aphakia mice: behavioral characterization of a novel genetic model of Parkinson's disease. J Neurosci 25(8):2132-7. [PubMed: 15728853]  [MGI Ref ID J:98209]

Ionita MA; Pittler SJ. 2007. Focus on molecules: rod cGMP phosphodiesterase type 6. Exp Eye Res 84(1):1-2. [PubMed: 16563379]  [MGI Ref ID J:123170]

Jia L; Oh EC; Ng L; Srinivas M; Brooks M; Swaroop A; Forrest D. 2009. Retinoid-related orphan nuclear receptor RORbeta is an early-acting factor in rod photoreceptor development. Proc Natl Acad Sci U S A 106(41):17534-9. [PubMed: 19805139]  [MGI Ref ID J:153683]

Johnson LE; van Veen T; Ekstrom PA. 2005. Differential Akt activation in the photoreceptors of normal and rd1 mice. Cell Tissue Res 320(2):213-22. [PubMed: 15789220]  [MGI Ref ID J:105103]

Jomary C; Cullen J; Jones SE. 2006. Inactivation of the Akt survival pathway during photoreceptor apoptosis in the retinal degeneration mouse. Invest Ophthalmol Vis Sci 47(4):1620-9. [PubMed: 16565401]  [MGI Ref ID J:108445]

Jomary C; Thomas M; Grist J; Milbrandt J; Neal MJ; Jones SE. 1999. Expression patterns of neurturin and its receptor components in developing and degenerative mouse retina. Invest Ophthalmol Vis Sci 40(3):568-74. [PubMed: 10067959]  [MGI Ref ID J:53298]

Jones BW; Watt CB; Frederick JM; Baehr W; Chen CK; Levine EM; Milam AH; Lavail MM; Marc RE. 2003. Retinal remodeling triggered by photoreceptor degenerations. J Comp Neurol 464(1):1-16. [PubMed: 12866125]  [MGI Ref ID J:84675]

Jones SE; Jomary C; Grist J; Stewart HJ; Neal MJ. 2000. Identification by array screening of altered nm23-M2/PuF mRNA expression in mouse retinal degeneration. Mol Cell Biol Res Commun 4(1):20-5. [PubMed: 11152623]  [MGI Ref ID J:66982]

Jones SE; Jomary C; Grist J; Thomas MR; Neal MJ. 1998. Expression of Pax-6 mRNA in the retinal degeneration (rd) mouse. Biochem Biophys Res Commun 252(1):236-40. [PubMed: 9813176]  [MGI Ref ID J:50978]

Jones SE; Jomary C; Grist J; Thomas MR; Neal MJ. 1998. Expression of alphaB-crystallin in a mouse model of inherited retinal degeneration. Neuroreport 9(18):4161-5. [PubMed: 9926867]  [MGI Ref ID J:52955]

Joseph RM; Li T. 1996. Overexpression of Bcl-2 or Bcl-XL transgenes and photoreceptor degeneration. Invest Ophthalmol Vis Sci 37(12):2434-46. [PubMed: 8933760]  [MGI Ref ID J:37285]

Kahle M; Horsch M; Fridrich B; Seelig A; Schultheiss J; Leonhardt J; Irmler M; Beckers J; Rathkolb B; Wolf E; Franke N; Gailus-Durner V; Fuchs H; de Angelis MH; Neschen S. 2013. Phenotypic comparison of common mouse strains developing high-fat diet-induced hepatosteatosis. Mol Metab 2(4):435-46. [PubMed: 24327959]  [MGI Ref ID J:220415]

Kanan Y; Hoffhines A; Rauhauser A; Murray A; Al-Ubaidi MR. 2009. Protein tyrosine-O-sulfation in the retina. Exp Eye Res 89(4):559-67. [PubMed: 19523945]  [MGI Ref ID J:154498]

Kaneko H; Nishiguchi KM; Nakamura M; Kachi S; Terasaki H. 2008. Retardation of photoreceptor degeneration in the detached retina of rd1 mouse. Invest Ophthalmol Vis Sci 49(2):781-7. [PubMed: 18235028]  [MGI Ref ID J:132586]

Karasawa K; Tanaka A; Jung K; Matsuda A; Okamoto N; Oida K; Ebihara N; Ohmori K; Matsuda H. 2011. Retinal degeneration and rd1 mutation in NC/Tnd mice-a human atopic dermatitis model. Curr Eye Res 36(4):350-7. [PubMed: 21275519]  [MGI Ref ID J:179794]

Katti C; Butler R; Sekaran S. 2013. Diurnal and circadian regulation of connexin 36 transcript and protein in the mammalian retina. Invest Ophthalmol Vis Sci 54(1):821-9. [PubMed: 23307963]  [MGI Ref ID J:214563]

Keady BT; Le YZ; Pazour GJ. 2011. IFT20 is required for opsin trafficking and photoreceptor outer segment development. Mol Biol Cell 22(7):921-30. [PubMed: 21307337]  [MGI Ref ID J:183002]

Keeler C. 1966. Retinal degeneration in the mouse is rodless retina. J Hered 57(2):47-50. [PubMed: 5916892]  [MGI Ref ID J:5007]

Keeler CE. 1926. On the Occurrence in the House Mouse of Mendelizing Structural Defect of the Retina Producing Blindness. Proc Natl Acad Sci U S A 12(4):255-8. [PubMed: 16576989]  [MGI Ref ID J:153354]

Keeler CE. 1924. The inheritance of a retinal abnormality in white mice Proc Natl Acad Sci U S A 10(7):329-33. [PubMed: 16576828]  [MGI Ref ID J:24999]

Keeler CE; Sutcliffe E; Chaffee EL. 1928. Normal and 'Rodless' Retinae of the House Mouse with Respect to the Electromotive Force Generated through Stimulation by Light. Proc Natl Acad Sci U S A 14(6):477-84. [PubMed: 16577134]  [MGI Ref ID J:153353]

Kida E; Rabe A; Walus M; Albertini G; Golabek AA. 2013. Long-term running alleviates some behavioral and molecular abnormalities in Down syndrome mouse model Ts65Dn. Exp Neurol 240:178-89. [PubMed: 23201095]  [MGI Ref ID J:196979]

Kirschman LT; Kolandaivelu S; Frederick JM; Dang L; Goldberg AF; Baehr W; Ramamurthy V. 2010. The Leber congenital amaurosis protein, AIPL1, is needed for the viability and functioning of cone photoreceptor cells. Hum Mol Genet 19(6):1076-87. [PubMed: 20042464]  [MGI Ref ID J:157652]

Klein SL; Kriegsfeld LJ; Hairston JE; Rau V; Nelson RJ; Yarowsky PJ. 1996. Characterization of sensorimotor performance, reproductive and aggressive behaviors in segmental trisomic 16 (Ts65Dn) mice. Physiol Behav 60(4):1159-64. [PubMed: 8884947]  [MGI Ref ID J:174274]

Kokkinopoulos I; Pearson RA; Macneil A; Dhomen NS; Maclaren RE; Ali RR; Sowden JC. 2008. Isolation and characterisation of neural progenitor cells from the adult Chx10(orJ/orJ) central neural retina. Mol Cell Neurosci 38(3):359-73. [PubMed: 18514541]  [MGI Ref ID J:137047]

Kolandaivelu S; Chang B; Ramamurthy V. 2011. Rod Phosphodiesterase-6 (PDE6) Catalytic Subunits Restore Cone Function in a Mouse Model Lacking Cone PDE6 Catalytic Subunit. J Biol Chem 286(38):33252-9. [PubMed: 21799013]  [MGI Ref ID J:176734]

Kolandaivelu S; Huang J; Hurley JB; Ramamurthy V. 2009. AIPL1, a protein associated with childhood blindness, interacts with alpha-subunit of rod phosphodiesterase (PDE6) and is essential for its proper assembly. J Biol Chem 284(45):30853-61. [PubMed: 19758987]  [MGI Ref ID J:156330]

Komeima K; Rogers BS; Lu L; Campochiaro PA. 2006. Antioxidants reduce cone cell death in a model of retinitis pigmentosa. Proc Natl Acad Sci U S A 103(30):11300-5. [PubMed: 16849425]  [MGI Ref ID J:111826]

Komeima K; Usui S; Shen J; Rogers BS; Campochiaro PA. 2008. Blockade of neuronal nitric oxide synthase reduces cone cell death in a model of retinitis pigmentosa. Free Radic Biol Med 45(6):905-12. [PubMed: 18634866]  [MGI Ref ID J:142007]

Kranz K; Paquet-Durand F; Weiler R; Janssen-Bienhold U; Dedek K. 2013. Testing for a gap junction-mediated bystander effect in retinitis pigmentosa: secondary cone death is not altered by deletion of connexin36 from cones. PLoS One 8(2):e57163. [PubMed: 23468924]  [MGI Ref ID J:199394]

Kucharska J; Del Rio P; Arango-Gonzalez B; Gorza M; Feuchtinger A; Hauck SM; Ueffing M. 2014. Cyr61 activates retinal cells and prolongs photoreceptor survival in rd1 mouse model of retinitis pigmentosa. J Neurochem 130(2):227-40. [PubMed: 24593181]  [MGI Ref ID J:213667]

Kuenzi F; Rosahl TW; Morton RA; Fitzjohn SM; Collingridge GL; Seabrook GR. 2003. Hippocampal synaptic plasticity in mice carrying the rd mutation in the gene encoding cGMP phosphodiesterase type 6 (PDE6). Brain Res 967(1-2):144-51. [PubMed: 12650975]  [MGI Ref ID J:82830]

LaVail MM; Matthes MT; Yasumura D; Steinberg RH. 1997. Variability in rate of cone degeneration in the retinal degeneration (rd/rd) mouse. Exp Eye Res 65(1):45-50. [PubMed: 9237863]  [MGI Ref ID J:42223]

LaVail MM; Mullen RJ. 1976. Role of the pigment epithelium in inherited retinal degeneration analyzed with experimental mouse chimeras. Exp Eye Res 23(2):227-45. [PubMed: 976367]  [MGI Ref ID J:5708]

LaVail MW; Yasumura D; Matthes MT; Lau-Villacorta C; Unoki K; Sung CH; Steinberg RH. 1998. Protection of mouse photoreceptors by survival factors in retinal degenerations. Invest Ophthalmol Vis Sci 39(3):592-602. [PubMed: 9501871]  [MGI Ref ID J:46230]

Lahdenranta J; Pasqualini R; Schlingemann RO; Hagedorn M; Stallcup WB; Bucana CD; Sidman RL; Arap W. 2001. An anti-angiogenic state in mice and humans with retinal photoreceptor cell degeneration. Proc Natl Acad Sci U S A 98(18):10368-73. [PubMed: 11526242]  [MGI Ref ID J:126744]

Langmann T; Di Gioia SA; Rau I; Stohr H; Maksimovic NS; Corbo JC; Renner AB; Zrenner E; Kumaramanickavel G; Karlstetter M; Arsenijevic Y; Weber BH; Gal A; Rivolta C. 2010. Nonsense mutations in FAM161A cause RP28-associated recessive retinitis pigmentosa. Am J Hum Genet 87(3):376-81. [PubMed: 20705278]  [MGI Ref ID J:169189]

Lavail MM; Nishikawa S; Duncan JL; Yang H; Matthes MT; Yasumura D; Vollrath D; Overbeek PA; Ash JD; Robinson ML. 2008. Sustained delivery of NT-3 from lens fiber cells in transgenic mice reveals specificity of neuroprotection in retinal degenerations. J Comp Neurol 511(6):724-35. [PubMed: 18925574]  [MGI Ref ID J:176641]

Lin B; Koizumi A; Tanaka N; Panda S; Masland RH. 2008. Restoration of visual function in retinal degeneration mice by ectopic expression of melanopsin. Proc Natl Acad Sci U S A 105(41):16009-14. [PubMed: 18836071]  [MGI Ref ID J:141434]

Lin B; Masland RH; Strettoi E. 2009. Remodeling of cone photoreceptor cells after rod degeneration in rd mice. Exp Eye Res 88(3):589-99. [PubMed: 19087876]  [MGI Ref ID J:146569]

Lin B; Peng EB. 2013. Retinal ganglion cells are resistant to photoreceptor loss in retinal degeneration. PLoS One 8(6):e68084. [PubMed: 23840814]  [MGI Ref ID J:204325]

Liu SH; Gottsch JD; Vinores SA; Derevjanik NL; McLeod DS; Lutty GA. 2001. EMAP cytokine expression in developing retinas of normal and retinal degeneration (rd) mutant mice. J Neuroimmunol 114(1-2):28-34. [PubMed: 11240012]  [MGI Ref ID J:102963]

Lohr HR; Kuntchithapautham K; Sharma AK; Rohrer B. 2006. Multiple, parallel cellular suicide mechanisms participate in photoreceptor cell death. Exp Eye Res 83(2):380-9. [PubMed: 16626700]  [MGI Ref ID J:116326]

Louros SR; Hooks BM; Litvina L; Carvalho AL; Chen C. 2014. A role for stargazin in experience-dependent plasticity. Cell Rep 7(5):1614-25. [PubMed: 24882000]  [MGI Ref ID J:211786]

Lu B; Coffey P; Lund R. 2004. Increased c-fos-like immunoreactivity in the superior colliculus and lateral geniculate nucleus of the rd mouse. Brain Res 1025(1-2):220-5. [PubMed: 15464763]  [MGI Ref ID J:107774]

Lucas RJ; Freedman MS; Munoz M; Garcia-Fernandez JM; Foster RG. 1999. Regulation of the mammalian pineal by non-rod, non-cone, ocular photoreceptors. Science 284(5413):505-7. [PubMed: 10205062]  [MGI Ref ID J:128478]

Lupi D; Oster H; Thompson S; Foster RG. 2008. The acute light-induction of sleep is mediated by OPN4-based photoreception. Nat Neurosci :. [PubMed: 18711396]  [MGI Ref ID J:141041]

Lupi D; Semo M; Foster RG. 2012. Impact of age and retinal degeneration on the light input to circadian brain structures. Neurobiol Aging 33(2):383-92. [PubMed: 20409612]  [MGI Ref ID J:188243]

Marc RE; Jones BW; Anderson JR; Kinard K; Marshak DW; Wilson JH; Wensel T; Lucas RJ. 2007. Neural reprogramming in retinal degeneration. Invest Ophthalmol Vis Sci 48(7):3364-71. [PubMed: 17591910]  [MGI Ref ID J:123271]

Margolis DJ; Gartland AJ; Singer JH; Detwiler PB. 2014. Network oscillations drive correlated spiking of ON and OFF ganglion cells in the rd1 mouse model of retinal degeneration. PLoS One 9(1):e86253. [PubMed: 24489706]  [MGI Ref ID J:212697]

Masana MI; Sumaya IC; Becker-Andre M; Dubocovich ML. 2007. Behavioral characterization and modulation of circadian rhythms by light and melatonin in C3H/HeN mice homozygous for the RORbeta knockout. Am J Physiol Regul Integr Comp Physiol 292(6):R2357-67. [PubMed: 17303680]  [MGI Ref ID J:121989]

Matynia A; Parikh S; Chen B; Kim P; McNeill DS; Nusinowitz S; Evans C; Gorin MB. 2012. Intrinsically photosensitive retinal ganglion cells are the primary but not exclusive circuit for light aversion. Exp Eye Res 105:60-9. [PubMed: 23078956]  [MGI Ref ID J:203664]

May A; Nimtschke U; May CA. 2009. The architecture of the mouse ciliary processes and their changes during retinal degeneration. Exp Eye Res 88(3):561-5. [PubMed: 19059237]  [MGI Ref ID J:146578]

May CA. 2009. Fibrae medullares in the retina of the RD mouse: a case report. Curr Eye Res 34(5):411-3. [PubMed: 19401885]  [MGI Ref ID J:149565]

McFadyen MP; Kusek G; Bolivar VJ; Flaherty L. 2003. Differences among eight inbred strains of mice in motor ability and motor learning on a rotorod. Genes Brain Behav 2(4):214-9. [PubMed: 12953787]  [MGI Ref ID J:104873]

McKenzie JA; Fruttiger M; Abraham S; Lange CA; Stone J; Gandhi P; Wang X; Bainbridge J; Moss SE; Greenwood J. 2012. Apelin is required for non-neovascular remodeling in the retina. Am J Pathol 180(1):399-409. [PubMed: 22067912]  [MGI Ref ID J:180164]

Meng R; Wu J; Harper DC; Wang Y; Kowalska MA; Abrams CS; Brass LF; Poncz M; Stalker TJ; Marks MS. 2015. Defective release of alpha granule and lysosome contents from platelets in mouse Hermansky-Pudlak syndrome models. Blood 125(10):1623-32. [PubMed: 25477496]  [MGI Ref ID J:221384]

Menu dit Huart L; Lorentz O; Goureau O; Leveillard T; Sahel JA. 2004. DNA repair in the degenerating mouse retina. Mol Cell Neurosci 26(3):441-9. [PubMed: 15234348]  [MGI Ref ID J:109747]

Menzler J; Channappa L; Zeck G. 2014. Rhythmic ganglion cell activity in bleached and blind adult mouse retinas. PLoS One 9(8):e106047. [PubMed: 25153888]  [MGI Ref ID J:219242]

Menzler J; Zeck G. 2011. Network oscillations in rod-degenerated mouse retinas. J Neurosci 31(6):2280-91. [PubMed: 21307264]  [MGI Ref ID J:169452]

Mitton KP; Guzman AE; Deshpande M; Byrd D; DeLooff C; Mkoyan K; Zlojutro P; Wallace A; Metcalf B; Laux K; Sotzen J; Tran T. 2014. Different effects of valproic acid on photoreceptor loss in Rd1 and Rd10 retinal degeneration mice. Mol Vis 20:1527-44. [PubMed: 25489226]  [MGI Ref ID J:220255]

Mohand-Said S; Deudon-Combe A; Hicks D; Simonutti M; Forster V ; Fintz AC ; Leveillard T ; Dreyfus H ; Sahel JA. 1998. Normal retina releases a diffusible factor stimulating cone survival in the retinal degeneration mouse. Proc Natl Acad Sci U S A 95(14):8357-62. [PubMed: 9653191]  [MGI Ref ID J:48731]

Montana CL; Kolesnikov AV; Shen SQ; Myers CA; Kefalov VJ; Corbo JC. 2013. Reprogramming of adult rod photoreceptors prevents retinal degeneration. Proc Natl Acad Sci U S A 110(5):1732-7. [PubMed: 23319618]  [MGI Ref ID J:193697]

Morin LP; Studholme KM. 2011. Separation of function for classical and ganglion cell photoreceptors with respect to circadian rhythm entrainment and induction of photosomnolence. Neuroscience 199:213-24. [PubMed: 21985934]  [MGI Ref ID J:184037]

Mrosovsky N; Foster RG; Salmon PA. 1999. Thresholds for masking responses to light in three strains of retinally degenerate mice. J Comp Physiol [A] 184(4):423-8. [PubMed: 10377976]  [MGI Ref ID J:56471]

Mrosovsky N; Hampton RR. 1997. Spatial responses to light in mice with severe retinal degeneration. Neurosci Lett 222(3):204-6. [PubMed: 9148250]  [MGI Ref ID J:40689]

Nakamura K; Harada C; Okumura A; Namekata K; Mitamura Y; Yoshida K; Ohno S; Yoshida H; Harada T. 2005. Effect of p75NTR on the regulation of photoreceptor apoptosis in the rd mouse. Mol Vis 11:1229-35. [PubMed: 16402023]  [MGI Ref ID J:136765]

Namekata K; Okumura A; Harada C; Nakamura K; Yoshida H; Harada T. 2006. Effect of photoreceptor degeneration on RNA splicing and expression of AMPA receptors. Mol Vis 12:1586-93. [PubMed: 17200657]  [MGI Ref ID J:117332]

Nishiguchi KM; Nakamura M; Kaneko H; Kachi S; Terasaki H. 2007. The role of VEGF and VEGFR2/Flk1 in proliferation of retinal progenitor cells in murine retinal degeneration. Invest Ophthalmol Vis Sci 48(9):4315-20. [PubMed: 17724222]  [MGI Ref ID J:126933]

Nishikawa S; LaVail MM. 1998. Neovascularization of the RPE: temporal differences in mice with rod photoreceptor gene defects. Exp Eye Res 67(5):509-15. [PubMed: 9878212]  [MGI Ref ID J:52112]

Nuhn JS; Fuerst PG. 2014. Developmental localization of adhesion and scaffolding proteins at the cone synapse. Gene Expr Patterns 16(1):36-50. [PubMed: 25176525]  [MGI Ref ID J:216508]

O'Leary TP; Brown RE. 2009. Visuo-spatial learning and memory deficits on the Barnes maze in the 16-month-old APPswe/PS1dE9 mouse model of Alzheimer's disease. Behav Brain Res 201(1):120-7. [PubMed: 19428625]  [MGI Ref ID J:148386]

Ogilvie JM; Hakenewerth AM; Gardner RR; Martak JG; Maggio VM. 2009. Dopamine receptor loss of function is not protective of rd1 rod photoreceptors in vivo. Mol Vis 15:2868-78. [PubMed: 20038975]  [MGI Ref ID J:157088]

Otani A; Kojima H; Guo C; Oishi A; Yoshimura N. 2012. Low-dose-rate, low-dose irradiation delays neurodegeneration in a model of retinitis pigmentosa. Am J Pathol 180(1):328-36. [PubMed: 22074737]  [MGI Ref ID J:180155]

Owens L; Buhr E; Tu DC; Lamprecht TL; Lee J; Van Gelder RN. 2012. Effect of circadian clock gene mutations on nonvisual photoreception in the mouse. Invest Ophthalmol Vis Sci 53(1):454-60. [PubMed: 22159024]  [MGI Ref ID J:191526]

Panda S; Provencio I; Tu DC; Pires SS; Rollag MD; Castrucci AM; Pletcher MT; Sato TK; Wiltshire T; Andahazy M; Kay SA; Van Gelder RN; Hogenesch JB. 2003. Melanopsin is required for non-image-forming photic responses in blind mice. Science 301(5632):525-7. [PubMed: 12829787]  [MGI Ref ID J:165769]

Panda S; Sato TK; Castrucci AM; Rollag MD; DeGrip WJ; Hogenesch JB; Provencio I; Kay SA. 2002. Melanopsin (Opn4) requirement for normal light-induced circadian phase shifting. Science 298(5601):2213-6. [PubMed: 12481141]  [MGI Ref ID J:81501]

Pang J; Cheng M; Haire SE; Barker E; Planelles V; Blanks JC. 2006. Efficiency of lentiviral transduction during development in normal and rd mice. Mol Vis 12:756-67. [PubMed: 16862069]  [MGI Ref ID J:111621]

Paper W; Kroeber M; Heersink S; Stephan DA; Fuchshofer R; Russell P; Tamm ER. 2008. Elevated amounts of myocilin in the aqueous humor of transgenic mice cause significant changes in ocular gene expression. Exp Eye Res 87(3):257-67. [PubMed: 18602390]  [MGI Ref ID J:141881]

Paquet-Durand F ; Hauck SM ; van Veen T ; Ueffing M ; Ekstrom P. 2009. PKG activity causes photoreceptor cell death in two retinitis pigmentosa models. J Neurochem 108(3):796-810. [PubMed: 19187097]  [MGI Ref ID J:146653]

Paquet-Durand F; Azadi S; Hauck SM; Ueffing M; van Veen T; Ekstrom P. 2006. Calpain is activated in degenerating photoreceptors in the rd1 mouse. J Neurochem 96(3):802-14. [PubMed: 16405498]  [MGI Ref ID J:106017]

Paquet-Durand F; Beck S; Michalakis S; Goldmann T; Huber G; Muhlfriedel R; Trifunovic D; Fischer MD; Fahl E; Duetsch G; Becirovic E; Wolfrum U; van Veen T; Biel M; Tanimoto N; Seeliger MW. 2011. A key role for cyclic nucleotide gated (CNG) channels in cGMP-related retinitis pigmentosa. Hum Mol Genet 20(5):941-7. [PubMed: 21149284]  [MGI Ref ID J:169039]

Park H; Tan CC; Faulkner A; Jabbar SB; Schmid G; Abey J; Iuvone PM; Pardue MT. 2013. Retinal degeneration increases susceptibility to myopia in mice. Mol Vis 19:2068-79. [PubMed: 24146540]  [MGI Ref ID J:205341]

Park SJ; Lee DS; Lim EJ; Choi SH; Kang WS; Kim IB; Chun MH. 2008. The absence of the clathrin-dependent endocytosis in rod bipolar cells of the FVB/N mouse retina. Neurosci Lett 439(2):165-9. [PubMed: 18514403]  [MGI Ref ID J:137049]

Peirson SN; Oster H; Jones SL; Leitges M; Hankins MW; Foster RG. 2007. Microarray analysis and functional genomics identify novel components of melanopsin signaling. Curr Biol 17(16):1363-72. [PubMed: 17702581]  [MGI Ref ID J:128396]

Peng GH; Chen S. 2007. Crx activates opsin transcription by recruiting HAT-containing co-activators and promoting histone acetylation. Hum Mol Genet 16(20):3433-52. [PubMed: 17656371]  [MGI Ref ID J:129889]

Pennesi ME; Michaels KV; Magee SS; Maricle A; Davin SP; Garg AK; Gale MJ; Tu DC; Wen Y; Erker LR; Francis PJ. 2012. Long-term characterization of retinal degeneration in rd1 and rd10 mice using spectral domain optical coherence tomography. Invest Ophthalmol Vis Sci 53(8):4644-56. [PubMed: 22562504]  [MGI Ref ID J:213983]

Petrasch-Parwez E; Habbes HW; Weickert S; Lobbecke-Schumacher M; Striedinger K; Wieczorek S; Dermietzel R; Epplen JT. 2004. Fine-structural analysis and connexin expression in the retina of a transgenic model of Huntington's disease. J Comp Neurol 479(2):181-97. [PubMed: 15452853]  [MGI Ref ID J:135880]

Phelan JK; Bok D. 2000. Analysis and quantitation of mRNAs encoding the alpha- and beta-subunits of rod photoreceptor cGMP phosphodiesterase in neonatal retinal degeneration (rd) mouse retinas. Exp Eye Res 71(2):119-28. [PubMed: 10930317]  [MGI Ref ID J:63861]

Pickard GE; Baver SB; Ogilvie MD; Sollars PJ. 2009. Light-induced fos expression in intrinsically photosensitive retinal ganglion cells in melanopsin knockout (opn4) mice. PLoS ONE 4(3):e4984. [PubMed: 19319185]  [MGI Ref ID J:147460]

Pittler SJ; Baehr W. 1991. Identification of a nonsense mutation in the rod photoreceptor cGMP phosphodiesterase beta-subunit gene of the rd mouse. Proc Natl Acad Sci U S A 88(19):8322-6. [PubMed: 1656438]  [MGI Ref ID J:11513]

Pittler SJ; Keeler CE; Sidman RL; Baehr W. 1993. PCR analysis of DNA from 70-year-old sections of rodless retina demonstrates identity with the mouse rd defect. Proc Natl Acad Sci U S A 90(20):9616-9. [PubMed: 8415750]  [MGI Ref ID J:15231]

Popper P; Farber DB; Micevych PE; Minoofar K; Bronstein JM. 1997. TRPM-2 expression and tunel staining in neurodegenerative diseases: studies in wobbler and rd mice. Exp Neurol 143(2):246-54. [PubMed: 9056387]  [MGI Ref ID J:38831]

Portera-Cailliau C; Sung CH; Nathans J; Adler R. 1994. Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa. Proc Natl Acad Sci U S A 91(3):974-8. [PubMed: 8302876]  [MGI Ref ID J:16708]

Provencio I; Cooper HM; Foster RG. 1998. Retinal projections in mice with inherited retinal degeneration: implications for circadian photoentrainment. J Comp Neurol 395(4):417-39. [PubMed: 9619497]  [MGI Ref ID J:47756]

Provencio I; Foster RG. 1995. Circadian rhythms in mice can be regulated by photoreceptors with cone-like characteristics. Brain Res 694(1-2):183-90. [PubMed: 8974643]  [MGI Ref ID J:29236]

Provencio I; Wong S; Lederman AB; Argamaso SM; Foster RG. 1994. Visual and circadian responses to light in aged retinally degenerate mice. Vision Res 34(14):1799-806. [PubMed: 7941382]  [MGI Ref ID J:19843]

Punzo C; Cepko C. 2007. Cellular responses to photoreceptor death in the rd1 mouse model of retinal degeneration. Invest Ophthalmol Vis Sci 48(2):849-57. [PubMed: 17251487]  [MGI Ref ID J:123282]

Punzo C; Kornacker K; Cepko CL. 2009. Stimulation of the insulin/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa. Nat Neurosci 12(1):44-52. [PubMed: 19060896]  [MGI Ref ID J:144720]

Qiao X; Pennesi M; Seong E; Gao H; Burmeister M; Wu SM. 2003. Photoreceptor degeneration and rd1 mutation in the grizzled/mocha mouse strain. Vision Res 43(8):859-65. [PubMed: 12668055]  [MGI Ref ID J:88031]

RIKEN BioResource Center/RIKEN Genomic Sciences Center. 2008. A Large Scale Mutagenesis Program in RIKEN GSC PhenoSITE, World Wide Web (URL: :.  [MGI Ref ID J:133634]

Rao A; Dallman R; Henderson S; Chen CK. 2007. Gbeta5 is required for normal light responses and morphology of retinal ON-bipolar cells. J Neurosci 27(51):14199-204. [PubMed: 18094259]  [MGI Ref ID J:129267]

Read DS; McCall MA; Gregg RG. 2002. Absence of voltage-dependent calcium channels delays photoreceptor degeneration in rd mice. Exp Eye Res 75(4):415-20. [PubMed: 12387789]  [MGI Ref ID J:79923]

Rich KA; Zhan Y; Blanks JC. 1997. Migration and synaptogenesis of cone photoreceptors in the developing mouse retina. J Comp Neurol 388(1):47-63. [PubMed: 9364238]  [MGI Ref ID J:44100]

Roesch K; Stadler MB; Cepko CL. 2012. Gene expression changes within Muller glial cells in retinitis pigmentosa. Mol Vis 18:1197-214. [PubMed: 22665967]  [MGI Ref ID J:191614]

Rohrer B; Demos C; Frigg R; Grimm C. 2007. Classical complement activation and acquired immune response pathways are not essential for retinal degeneration in the rd1 mouse. Exp Eye Res 84(1):82-91. [PubMed: 17069800]  [MGI Ref ID J:123183]

Rossi C; Strettoi E; Galli-Resta L. 2003. The spatial order of horizontal cells is not affected by massive alterations in the organization of other retinal cells. J Neurosci 23(30):9924-8. [PubMed: 14586022]  [MGI Ref ID J:120041]

Ruan GX; Allen GC; Yamazaki S; McMahon DG. 2008. An autonomous circadian clock in the inner mouse retina regulated by dopamine and GABA. PLoS Biol 6(10):e249. [PubMed: 18959477]  [MGI Ref ID J:141081]

Ruggiero L; Allen CN; Lane Brown R; Robinson DW. 2009. The development of melanopsin-containing retinal ganglion cells in mice with early retinal degeneration. Eur J Neurosci 29(2):359-67. [PubMed: 19200239]  [MGI Ref ID J:146465]

Ryu SB; Ye JH; Goo YS; Kim CH; Kim KH. 2010. Temporal response properties of retinal ganglion cells in rd1 mice evoked by amplitude-modulated electrical pulse trains. Invest Ophthalmol Vis Sci 51(12):6762-9. [PubMed: 20671284]  [MGI Ref ID J:171389]


Sahaboglu A; Tanimoto N; Kaur J; Sancho-Pelluz J; Huber G; Fahl E; Arango-Gonzalez B; Zrenner E; Ekstrom P; Lowenheim H; Seeliger M; Paquet-Durand F. 2010. PARP1 gene knock-out increases resistance to retinal degeneration without affecting retinal function. PLoS One 5(11):e15495. [PubMed: 21124852]  [MGI Ref ID J:167317]

Samardzija M; Wenzel A; Aufenberg S; Thiersch M; Reme C; Grimm C. 2006. Differential role of Jak-STAT signaling in retinal degenerations. FASEB J 20(13):2411-3. [PubMed: 16966486]  [MGI Ref ID J:114638]

Samardzija M; Wenzel A; Thiersch M; Frigg R; Reme C; Grimm C. 2006. Caspase-1 ablation protects photoreceptors in a model of autosomal dominant retinitis pigmentosa. Invest Ophthalmol Vis Sci 47(12):5181-90. [PubMed: 17122101]  [MGI Ref ID J:123100]

Sancho-Pelluz J; Wunderlich KA; Rauch U; Romero FJ; van Veen T; Limb GA; Crocker PR; Perez MT. 2008. Sialoadhesin expression in intact degenerating retinas and following transplantation. Invest Ophthalmol Vis Sci 49(12):5602-10. [PubMed: 18641281]  [MGI Ref ID J:142000]

Sanz MM; Johnson LE; Ahuja S; Ekstrom PA; Romero J; van Veen T. 2007. Significant photoreceptor rescue by treatment with a combination of antioxidants in an animal model for retinal degeneration. Neuroscience 145(3):1120-9. [PubMed: 17293057]  [MGI Ref ID J:121644]

Sasahara M; Otani A; Oishi A; Kojima H; Yodoi Y; Kameda T; Nakamura H; Yoshimura N. 2008. Activation of bone marrow-derived microglia promotes photoreceptor survival in inherited retinal degeneration. Am J Pathol 172(6):1693-703. [PubMed: 18483210]  [MGI Ref ID J:136339]

Schmidt SY; Lolley RN. 1973. Cyclic-nucleotide phosphodiesterase: an early defect in inherited retinal degeneration of C3H mice. J Cell Biol 57(1):117-23. [PubMed: 4347974]  [MGI Ref ID J:5332]

Scott A; Powner MB; Fruttiger M. 2014. Quantification of vascular tortuosity as an early outcome measure in oxygen induced retinopathy (OIR). Exp Eye Res 120:55-60. [PubMed: 24418725]  [MGI Ref ID J:210367]

Selby CP; Thompson C; Schmitz TM; Van Gelder RN; Sancar A. 2000. Functional redundancy of cryptochromes and classical photoreceptors for nonvisual ocular photoreception in mice Proc Natl Acad Sci U S A 97(26):14697-702. [PubMed: 11114194]  [MGI Ref ID J:66580]

Semo M; Gias C; Ahmado A; Sugano E; Allen AE; Lawrence JM; Tomita H; Coffey PJ; Vugler AA. 2010. Dissecting a role for melanopsin in behavioural light aversion reveals a response independent of conventional photoreception. PLoS One 5(11):e15009. [PubMed: 21124784]  [MGI Ref ID J:167120]

Semo M; Lupi D; Peirson SN; Butler JN; Foster RG. 2003. Light-induced c-fos in melanopsin retinal ganglion cells of young and aged rodless/coneless (rd/rd cl) mice. Eur J Neurosci 18(11):3007-17. [PubMed: 14656296]  [MGI Ref ID J:89691]

Semo M; Peirson S; Lupi D; Lucas RJ; Jeffery G; Foster RG. 2003. Melanopsin retinal ganglion cells and the maintenance of circadian and pupillary responses to light in aged rodless/coneless (rd/rd cl) mice. Eur J Neurosci 17(9):1793-801. [PubMed: 12752778]  [MGI Ref ID J:128149]

Sharma AK; Rohrer B. 2007. Sustained elevation of intracellular cGMP causes oxidative stress triggering calpain-mediated apoptosis in photoreceptor degeneration. Curr Eye Res 32(3):259-69. [PubMed: 17453946]  [MGI Ref ID J:121112]

Sheedlo HJ; Jaynes D; Bolan AL; Turner JE. 1995. Mullerian glia in dystrophic rodent retinas: an immunocytochemical analysis. Brain Res Dev Brain Res 85(2):171-80. [PubMed: 7600664]  [MGI Ref ID J:24543]

Srinivasan Y; Lovicu FJ; Overbeek PA. 1998. Lens-specific expression of transforming growth factor beta1 in transgenic mice causes anterior subcapsular cataracts. J Clin Invest 101(3):625-34. [PubMed: 9449696]  [MGI Ref ID J:135895]

Stone C; Pinto LH. 1993. Response properties of ganglion cells in the isolated mouse retina. Vis Neurosci 10(1):31-9. [PubMed: 8424927]  [MGI Ref ID J:116795]

Strettoi E; Pignatelli V. 2000. Modifications of retinal neurons in a mouse model of retinitis pigmentosa Proc Natl Acad Sci U S A 97(20):11020-5. [PubMed: 10995468]  [MGI Ref ID J:64742]

Strettoi E; Pignatelli V; Rossi C; Porciatti V; Falsini B. 2003. Remodeling of second-order neurons in the retina of rd/rd mutant mice. Vision Res 43(8):867-77. [PubMed: 12668056]  [MGI Ref ID J:92316]

Strettoi E; Porciatti V; Falsini B; Pignatelli V; Rossi C. 2002. Morphological and functional abnormalities in the inner retina of the rd/rd mouse. J Neurosci 22(13):5492-504. [PubMed: 12097501]  [MGI Ref ID J:109225]

Sumaya IC; Masana MI; Dubocovich ML. 2005. The antidepressant-like effect of the melatonin receptor ligand luzindole in mice during forced swimming requires expression of MT2 but not MT1 melatonin receptors. J Pineal Res 39(2):170-7. [PubMed: 16098095]  [MGI Ref ID J:114318]

Takahashi M; Miyoshi H; Verma IM; Gage FH. 1999. Rescue from photoreceptor degeneration in the rd mouse by human immunodeficiency virus vector-mediated gene transfer. J Virol 73(9):7812-6. [PubMed: 10438872]  [MGI Ref ID J:56759]

Tansley K. 1954. An inherited retinal degeneration in the mouse J Hered 45:123-27.  [MGI Ref ID J:15333]

Thaung C; Arnold K; Jackson IJ; Coffey PJ. 2002. Presence of visual head tracking differentiates normal sighted from retinal degenerate mice. Neurosci Lett 325(1):21-4. [PubMed: 12023058]  [MGI Ref ID J:107978]

Thompson CL; Selby CP; Partch CL; Plante DT; Thresher RJ; Araujo F; Sancar A. 2004. Further evidence for the role of cryptochromes in retinohypothalamic photoreception/phototransduction. Brain Res Mol Brain Res 122(2):158-66. [PubMed: 15010208]  [MGI Ref ID J:88468]

Thompson S; Foster RG; Stone EM; Sheffield VC; Mrosovsky N. 2008. Classical and melanopsin photoreception in irradiance detection: negative masking of locomotor activity by light. Eur J Neurosci 27(8):1973-9. [PubMed: 18412618]  [MGI Ref ID J:136825]

Thompson S; Lupi D; Hankins MW; Peirson SN; Foster RG. 2008. The effects of rod and cone loss on the photic regulation of locomotor activity and heart rate. Eur J Neurosci 28(4):724-9. [PubMed: 18702692]  [MGI Ref ID J:140577]

Thompson S; Mullins RF; Philp AR; Stone EM; Mrosovsky N. 2008. Divergent phenotypes of vision and accessory visual function in mice with visual cycle dysfunction (Rpe65 rd12) or retinal degeneration (rd/rd). Invest Ophthalmol Vis Sci 49(6):2737-42. [PubMed: 18515598]  [MGI Ref ID J:137044]

Thompson S; Stasheff SF; Hernandez J; Nylen E; East JS; Kardon RH; Pinto LH; Mullins RF; Stone EM. 2011. Different inner retinal pathways mediate rod-cone input in irradiance detection for the pupillary light reflex and regulation of behavioral state in mice. Invest Ophthalmol Vis Sci 52(1):618-23. [PubMed: 20847113]  [MGI Ref ID J:171559]

Thyagarajan S; van Wyk M; Lehmann K; Lowel S; Feng G; Wassle H. 2010. Visual function in mice with photoreceptor degeneration and transgenic expression of channelrhodopsin 2 in ganglion cells. J Neurosci 30(26):8745-58. [PubMed: 20592196]  [MGI Ref ID J:161847]

Tochitsky I; Polosukhina A; Degtyar VE; Gallerani N; Smith CM; Friedman A; Van Gelder RN; Trauner D; Kaufer D; Kramer RH. 2014. Restoring visual function to blind mice with a photoswitch that exploits electrophysiological remodeling of retinal ganglion cells. Neuron 81(4):800-13. [PubMed: 24559673]  [MGI Ref ID J:220643]

Tsang SH; Gouras P; Yamashita CK; Kjeldbye H; Fisher J; Farber DB; Goff SP. 1996. Retinal degeneration in mice lacking the gamma subunit of the rod cGMP phosphodiesterase. Science 272(5264):1026-9. [PubMed: 8638127]  [MGI Ref ID J:33048]

Tu DC; Owens LA; Anderson L; Golczak M; Doyle SE; McCall M; Menaker M; Palczewski K; Van Gelder RN. 2006. Inner retinal photoreception independent of the visual retinoid cycle. Proc Natl Acad Sci U S A 103(27):10426-31. [PubMed: 16788071]  [MGI Ref ID J:111700]

Tu DC; Zhang D; Demas J; Slutsky EB; Provencio I; Holy TE; Van Gelder RN. 2005. Physiologic diversity and development of intrinsically photosensitive retinal ganglion cells. Neuron 48(6):987-99. [PubMed: 16364902]  [MGI Ref ID J:107606]

Tucker B; Klassen H; Yang L; Chen DF; Young MJ. 2008. Elevated MMP Expression in the MRL Mouse Retina Creates a Permissive Environment for Retinal Regeneration. Invest Ophthalmol Vis Sci 49(4):1686-95. [PubMed: 18385092]  [MGI Ref ID J:136153]

Usui S; Oveson BC; Lee SY; Jo YJ; Yoshida T; Miki A; Miki K; Iwase T; Lu L; Campochiaro PA. 2009. NADPH oxidase plays a central role in cone cell death in retinitis pigmentosa. J Neurochem 110(3):1028-37. [PubMed: 19493169]  [MGI Ref ID J:152819]

Van Gelder RN; Wee R; Lee JA; Tu DC. 2003. Reduced pupillary light responses in mice lacking cryptochromes. Science 299(5604):222. [PubMed: 12522242]  [MGI Ref ID J:81500]

Vazquez-Chona FR; Clark AM; Levine EM. 2009. Rlbp1 promoter drives robust Muller glial GFP expression in transgenic mice. Invest Ophthalmol Vis Sci 50(8):3996-4003. [PubMed: 19324864]  [MGI Ref ID J:154561]

Viczian A; Sanyal S; Toffenetti J; Chader GJ; Farber DB. 1992. Photoreceptor-specific mRNAs in mice carrying different allelic combinations at the rd and rds loci. Exp Eye Res 54(6):853-60. [PubMed: 1381682]  [MGI Ref ID J:2579]

Vlachantoni D; Bramall AN; Murphy MP; Taylor RW; Shu X; Tulloch B; Van Veen T; Turnbull DM; McInnes RR; Wright AF. 2011. Evidence of severe mitochondrial oxidative stress and a protective effect of low oxygen in mouse models of inherited photoreceptor degeneration. Hum Mol Genet 20(2):322-35. [PubMed: 21051333]  [MGI Ref ID J:166898]

Wahlin KJ; Adler R; Zack DJ; Campochiaro PA. 2001. Neurotrophic signaling in normal and degenerating rodent retinas. Exp Eye Res 73(5):693-701. [PubMed: 11747369]  [MGI Ref ID J:73377]

Wang Y; Wang ZY; Zhou MN; Cai J; Sun LY; Liu XY; Daugherty BL; Pestka S. 1997. Sequencing and bacterial expression of a novel murine alpha interferon gene. Sci China C Life Sci 40(3):277-283.  [MGI Ref ID J:41297]

Warthen DM; Wiltgen BJ; Provencio I. 2011. Light enhances learned fear. Proc Natl Acad Sci U S A 108(33):13788-93. [PubMed: 21808002]  [MGI Ref ID J:175610]

Welge-Lussen U; Wilsch C; Neuhardt T; Wayne Streilein J; Lutjen-Drecoll E. 1999. Loss of anterior chamber-associated immune deviation (ACAID) in aged retinal degeneration (rd) mice. Invest Ophthalmol Vis Sci 40(13):3209-14. [PubMed: 10586944]  [MGI Ref ID J:58745]

Won J; Shi LY; Hicks W; Wang J; Hurd R; Naggert JK; Chang B; Nishina PM. 2011. Mouse model resources for vision research. J Ophthalmol 2011:391384. [PubMed: 21052544]  [MGI Ref ID J:166679]

Wong P; Borst DE; Farber D; Danciger JS; Tenniswood M; Chader GJ; van Veen T. 1994. Increased TRPM-2/clusterin mRNA levels during the time of retinal degeneration in mouse models of retinitis pigmentosa. Biochem Cell Biol 72(9-10):439-46. [PubMed: 7605616]  [MGI Ref ID J:24128]

Wu J; Trogadis J; Bremner R. 2001. Rod and cone degeneration in the rd mouse is p53 independent. Mol Vis 7:101-6. [PubMed: 11344337]  [MGI Ref ID J:126023]

Wunderlich KA; Leveillard T; Penkowa M; Zrenner E; Perez MT. 2010. Altered expression of metallothionein-I and -II and their receptor megalin in inherited photoreceptor degeneration. Invest Ophthalmol Vis Sci 51(9):4809-20. [PubMed: 20357188]  [MGI Ref ID J:164094]

Yamada H; Yamada E; Hackett SF; Ozaki H; Okamoto N; Campochiaro PA. 1999. Hyperoxia causes decreased expression of vascular endothelial growth factor and endothelial cell apoptosis in adult retina. J Cell Physiol 179(2):149-56. [PubMed: 10199554]  [MGI Ref ID J:54326]

Yan W; Lewin A; Hauswirth W. 1998. Selective degradation of nonsense beta-phosphodiesterase mRNA in the heterozygous rd mouse. Invest Ophthalmol Vis Sci 39(13):2529-36. [PubMed: 9856762]  [MGI Ref ID J:51361]

Yang LP; Wu LM; Guo XJ; Tso MO. 2007. Activation of endoplasmic reticulum stress in degenerating photoreceptors of the rd1 mouse. Invest Ophthalmol Vis Sci 48(11):5191-8. [PubMed: 17962473]  [MGI Ref ID J:127157]

Yazulla S; Studholme KM; Pinto LH. 1997. Differences in the retinal GABA system among control, spastic mutant and retinal degeneration mutant mice. Vision Res 37(24):3471-82. [PubMed: 9425524]  [MGI Ref ID J:45280]

Yi H; Nakamura RE; Mohamed O; Dufort D; Hackam AS. 2007. Characterization of Wnt signaling during photoreceptor degeneration. Invest Ophthalmol Vis Sci 48(12):5733-41. [PubMed: 18055826]  [MGI Ref ID J:132500]

Yoshimura T; Ebihara S. 1998. Decline of circadian photosensitivity associated with retinal degeneration in CBA/J-rd/rd mice. Brain Res 779(1-2):188-93. [PubMed: 9473668]  [MGI Ref ID J:45462]

Yoshimura T; Ebihara S. 1996. Spectral sensitivity of photoreceptors mediating phase-shifts of circadian rhythms in retinally degenerate CBA/J (rd/rd) and normal CBA/N (+/+)mice. J Comp Physiol [A] 178(6):797-802. [PubMed: 8667293]  [MGI Ref ID J:33685]

Yoshimura T; Nishio M; Goto M; Ebihara S. 1994. Differences in circadian photosensitivity between retinally degenerate CBA/J mice (rd/rd) and normal CBA/N mice (+/+). J Biol Rhythms 9(1):51-60. [PubMed: 7949306]  [MGI Ref ID J:19351]

Yoshimura T; Yokota Y; Ishikawa A; Yasuo S; Hayashi N; Suzuki T; Okabayashi N; Namikawa T; Ebihara S. 2002. Mapping quantitative trait loci affecting circadian photosensitivity in retinally degenerate mice. J Biol Rhythms 17(6):512-9. [PubMed: 12465884]  [MGI Ref ID J:80788]

Zeiss CJ; Johnson EA. 2004. Proliferation of microglia, but not photoreceptors, in the outer nuclear layer of the rd-1 mouse. Invest Ophthalmol Vis Sci 45(3):971-6. [PubMed: 14985319]  [MGI Ref ID J:109731]

Zeiss CJ; Neal J; Johnson EA. 2004. Caspase-3 in postnatal retinal development and degeneration. Invest Ophthalmol Vis Sci 45(3):964-70. [PubMed: 14985318]  [MGI Ref ID J:88367]

Zencak D; Crippa SV; Tekaya M; Tanger E; Schorderet DE; Munier FL; van Lohuizen M; Arsenijevic Y. 2006. BMI1 loss delays photoreceptor degeneration in Rd1 mice. Bmi1 loss and neuroprotection in Rd1 mice. Adv Exp Med Biol 572:209-15. [PubMed: 17249577]  [MGI Ref ID J:154016]

Zencak D; Schouwey K; Chen D; Ekstrom P; Tanger E; Bremner R; van Lohuizen M; Arsenijevic Y. 2013. Retinal degeneration depends on Bmi1 function and reactivation of cell cycle proteins. Proc Natl Acad Sci U S A 110(7):E593-601. [PubMed: 23359713]  [MGI Ref ID J:194322]

Zeng H; Ding M; Chen XX; Lu Q. 2014. Microglial NADPH oxidase activation mediates rod cell death in the retinal degeneration in rd mice. Neuroscience 275:54-61. [PubMed: 24929065]  [MGI Ref ID J:215397]

Zeng HY; Lu QJ; Liu Q; Liu KG; Wang NL. 2011. The role of CCR1 expression in the retinal degeneration in rd mice. Curr Eye Res 36(3):264-9. [PubMed: 21275605]  [MGI Ref ID J:179793]

Zhang N; Kolesnikov AV; Jastrzebska B; Mustafi D; Sawada O; Maeda T; Genoud C; Engel A; Kefalov VJ; Palczewski K. 2013. Autosomal recessive retinitis pigmentosa E150K opsin mice exhibit photoreceptor disorganization. J Clin Invest 123(1):121-37. [PubMed: 23221340]  [MGI Ref ID J:194158]

Zhu Y; Tu DC; Denner D; Shane T; Fitzgerald CM; Van Gelder RN. 2007. Melanopsin-dependent persistence and photopotentiation of murine pupillary light responses. Invest Ophthalmol Vis Sci 48(3):1268-75. [PubMed: 17325172]  [MGI Ref ID J:123259]

Tlr4Lps-d related

Abel B; Thieblemont N; Quesniaux VJ; Brown N; Mpagi J; Miyake K; Bihl F; Ryffel B. 2002. Toll-like receptor 4 expression is required to control chronic Mycobacterium tuberculosis infection in mice. J Immunol 169(6):3155-62. [PubMed: 12218133]  [MGI Ref ID J:78959]

An CH; Wang XM; Lam HC; Ifedigbo E; Washko GR; Ryter SW; Choi AM. 2012. TLR4 deficiency promotes autophagy during cigarette smoke-induced pulmonary emphysema. Am J Physiol Lung Cell Mol Physiol 303(9):L748-57. [PubMed: 22983353]  [MGI Ref ID J:193661]

Andonegui G; Bonder CS; Green F; Mullaly SC; Zbytnuik L; Raharjo E; Kubes P. 2003. Endothelium-derived Toll-like receptor-4 is the key molecule in LPS-induced neutrophil sequestration into lungs. J Clin Invest 111(7):1011-20. [PubMed: 12671050]  [MGI Ref ID J:82623]

Andonegui G; Goyert SM; Kubes P. 2002. Lipopolysaccharide-induced leukocyte-endothelial cell interactions: a role for CD14 versus toll-like receptor 4 within microvessels. J Immunol 169(4):2111-9. [PubMed: 12165539]  [MGI Ref ID J:120701]

Apte RN; Ascher O; Pluznik DH. 1977. Relationship between lipopolysaccharide-induced serum colony stimulating factor and interferon in regulation of murine granulopoiesis Exp Hematol 5(Suppl 2):12 (Abstr.).  [MGI Ref ID J:30692]

Arizmendi NG; Abel M; Mihara K; Davidson C; Polley D; Nadeem A; El Mays T; Gilmore BF; Walker B; Gordon JR; Hollenberg MD; Vliagoftis H. 2011. Mucosal allergic sensitization to cockroach allergens is dependent on proteinase activity and proteinase-activated receptor-2 activation. J Immunol 186(5):3164-72. [PubMed: 21270400]  [MGI Ref ID J:169393]

Askenase PW; Itakura A; Leite-de-Moraes MC; Lisbonne M; Roongapinun S; Goldstein DR; Szczepanik M. 2005. TLR-dependent IL-4 production by invariant Valpha14+Jalpha18+ NKT cells to initiate contact sensitivity in vivo. J Immunol 175(10):6390-401. [PubMed: 16272291]  [MGI Ref ID J:119381]

Babcock AA; Toft-Hansen H; Owens T. 2008. Signaling through MyD88 regulates leukocyte recruitment after brain injury. J Immunol 181(9):6481-90. [PubMed: 18941239]  [MGI Ref ID J:140719]

Babcock AA; Wirenfeldt M; Holm T; Nielsen HH; Dissing-Olesen L; Toft-Hansen H; Millward JM; Landmann R; Rivest S; Finsen B; Owens T. 2006. Toll-like receptor 2 signaling in response to brain injury: an innate bridge to neuroinflammation. J Neurosci 26(49):12826-37. [PubMed: 17151286]  [MGI Ref ID J:116760]

Babelova A; Moreth K; Tsalastra-Greul W; Zeng-Brouwers J; Eickelberg O; Young MF; Bruckner P; Pfeilschifter J; Schaefer RM; Grone HJ; Schaefer L. 2009. Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors. J Biol Chem 284(36):24035-48. [PubMed: 19605353]  [MGI Ref ID J:155256]

Bachmaier K; Toya S; Malik AB. 2014. Therapeutic administration of the chemokine CXCL1/KC abrogates autoimmune inflammatory heart disease. PLoS One 9(2):e89647. [PubMed: 24586934]  [MGI Ref ID J:214482]

Bandukwala HS; Clay BS; Tong J; Mody PD; Cannon JL; Shilling RA; Verbeek JS; Weinstock JV; Solway J; Sperling AI. 2007. Signaling through Fc gamma RIII is required for optimal T helper type (Th)2 responses and Th2-mediated airway inflammation. J Exp Med 204(8):1875-89. [PubMed: 17664287]  [MGI Ref ID J:125951]

Barber SA; Perera PY; Vogel SN. 1995. Defective ceramide response in C3H/HeJ (Lpsd) macrophages. J Immunol 155(5):2303-5. [PubMed: 7650365]  [MGI Ref ID J:28193]

Barrett TJ; Potter ME; Strockbine NA. 1990. Evidence for participation of the macrophage in Shiga-like toxin II-induced lethality in mice. Microb Pathog 9(2):95-103. [PubMed: 2277589]  [MGI Ref ID J:25812]

Barsness KA; Arcaroli J; Harken AH; Abraham E; Banerjee A; Reznikov L; McIntyre RC. 2004. Hemorrhage-induced acute lung injury is TLR-4 dependent. Am J Physiol Regul Integr Comp Physiol 287(3):R592-9. [PubMed: 15072965]  [MGI Ref ID J:95788]

Basu S; Kang TJ; Chen WH; Fenton MJ; Baillie L; Hibbs S; Cross AS. 2007. Role of Bacillus anthracis spore structures in macrophage cytokine responses. Infect Immun 75(5):2351-8. [PubMed: 17339355]  [MGI Ref ID J:121885]

Bauer AK; Dixon D; DeGraff LM; Cho HY; Walker CR; Malkinson AM; Kleeberger SR. 2005. Toll-like receptor 4 in butylated hydroxytoluene-induced mouse pulmonary inflammation and tumorigenesis. J Natl Cancer Inst 97(23):1778-81. [PubMed: 16333033]  [MGI Ref ID J:104658]

Baumgarten G; Knuefermann P; Nozaki N; Sivasubramanian N; Mann DL; Vallejo JG. 2001. In vivo expression of proinflammatory mediators in the adult heart after endotoxin administration: the role of toll-like receptor-4. J Infect Dis 183(11):1617-24. [PubMed: 11343210]  [MGI Ref ID J:120520]

Benjamin JT; Carver BJ; Plosa EJ; Yamamoto Y; Miller JD; Liu JH; van der Meer R; Blackwell TS; Prince LS. 2010. NF-kappaB activation limits airway branching through inhibition of Sp1-mediated fibroblast growth factor-10 expression. J Immunol 185(8):4896-903. [PubMed: 20861353]  [MGI Ref ID J:164723]

Berguer PM; Mundinano J; Piazzon I; Goldbaum FA. 2006. A polymeric bacterial protein activates dendritic cells via TLR4. J Immunol 176(4):2366-72. [PubMed: 16455994]  [MGI Ref ID J:129193]

Bhan U; Ballinger MN; Zeng X; Newstead MJ; Cornicelli MD; Standiford TJ. 2010. Cooperative interactions between TLR4 and TLR9 regulate interleukin 23 and 17 production in a murine model of gram negative bacterial pneumonia. PLoS One 5(3):e9896. [PubMed: 20360853]  [MGI Ref ID J:158954]

Bhattacharyya S; Kelley K; Melichian DS; Tamaki Z; Fang F; Su Y; Feng G; Pope RM; Budinger GR; Mutlu GM; Lafyatis R; Radstake T; Feghali-Bostwick C; Varga J. 2013. Toll-like receptor 4 signaling augments transforming growth factor-beta responses: a novel mechanism for maintaining and amplifying fibrosis in scleroderma. Am J Pathol 182(1):192-205. [PubMed: 23141927]  [MGI Ref ID J:192234]

Bou Ghanem EN; McElroy DS; D'Orazio SE. 2009. Multiple mechanisms contribute to the robust rapid gamma interferon response by CD8+ T cells during Listeria monocytogenes infection. Infect Immun 77(4):1492-501. [PubMed: 19179413]  [MGI Ref ID J:147169]

Braedel S; Radsak M; Einsele H; Latge JP; Michan A; Loeffler J; Haddad Z; Grigoleit U; Schild H; Hebart H. 2004. Aspergillus fumigatus antigens activate innate immune cells via toll-like receptors 2 and 4. Br J Haematol 125(3):392-9. [PubMed: 15086422]  [MGI Ref ID J:89264]

Branger J; Knapp S; Weijer S; Leemans JC; Pater JM; Speelman P; Florquin S; van der Poll T. 2004. Role of Toll-like receptor 4 in gram-positive and gram-negative pneumonia in mice. Infect Immun 72(2):788-94. [PubMed: 14742522]  [MGI Ref ID J:87807]

Buchholz BM; Billiar TR; Bauer AJ. 2010. Dominant role of the MyD88-dependent signaling pathway in mediating early endotoxin-induced murine ileus. Am J Physiol Gastrointest Liver Physiol 299(2):G531-8. [PubMed: 20508155]  [MGI Ref ID J:163354]

Buchholz BM; Chanthaphavong RS; Bauer AJ. 2009. Nonhemopoietic cell TLR4 signaling is critical in causing early lipopolysaccharide-induced ileus. J Immunol 183(10):6744-53. [PubMed: 19846874]  [MGI Ref ID J:157181]

Bunt SK; Clements VK; Hanson EM; Sinha P; Ostrand-Rosenberg S. 2009. Inflammation enhances myeloid-derived suppressor cell cross-talk by signaling through Toll-like receptor 4. J Leukoc Biol 85(6):996-1004. [PubMed: 19261929]  [MGI Ref ID J:149766]

Burch LH; Yang IV; Whitehead GS; Chao FG; Berman KG; Schwartz DA. 2006. The transcriptional response to lipopolysaccharide reveals a role for interferon-gamma in lung neutrophil recruitment. Am J Physiol Lung Cell Mol Physiol 291(4):L677-82. [PubMed: 16766576]  [MGI Ref ID J:144404]

Cabanski M; Steinmuller M; Marsh LM; Surdziel E; Seeger W; Lohmeyer J. 2008. PKR regulates TLR2/TLR4-dependent signaling in murine alveolar macrophages. Am J Respir Cell Mol Biol 38(1):26-31. [PubMed: 17690330]  [MGI Ref ID J:142999]

Campos MA; Rosinha GM; Almeida IC; Salgueiro XS; Jarvis BW; Splitter GA; Qureshi N; Bruna-Romero O; Gazzinelli RT; Oliveira SC. 2004. Role of Toll-like receptor 4 in induction of cell-mediated immunity and resistance to Brucella abortus infection in mice. Infect Immun 72(1):176-86. [PubMed: 14688095]  [MGI Ref ID J:87836]

Canale-Zambrano JC; Auger ML; Haston CK. 2010. Toll-like receptor-4 genotype influences the survival of cystic fibrosis mice. Am J Physiol Gastrointest Liver Physiol 299(2):G381-90. [PubMed: 20522639]  [MGI Ref ID J:163347]

Cao CX; Yang QW; Lv FL; Cui J; Fu HB; Wang JZ. 2007. Reduced cerebral ischemia-reperfusion injury in Toll-like receptor 4 deficient mice. Biochem Biophys Res Commun 353(2):509-14. [PubMed: 17188246]  [MGI Ref ID J:117223]

Carmona J; Cruz A; Moreira-Teixeira L; Sousa C; Sousa J; Osorio NS; Saraiva AL; Svenson S; Kallenius G; Pedrosa J; Rodrigues F; Castro AG; Saraiva M. 2013. Strains Are Differentially Recognized by TLRs with an Impact on the Immune Response. PLoS One 8(6):e67277. [PubMed: 23840651]  [MGI Ref ID J:203717]

Caso JR; Pradillo JM; Hurtado O; Lorenzo P; Moro MA; Lizasoain I. 2007. Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke. Circulation 115(12):1599-608. [PubMed: 17372179]  [MGI Ref ID J:133065]

Cenedeze MA; Goncalves GM; Feitoza CQ; Wang PM; Damiao MJ; Bertocchi AP; Pacheco-Silva A; Camara NO. 2007. The role of toll-like receptor 4 in cisplatin-induced renal injury. Transplant Proc 39(2):409-11. [PubMed: 17362743]  [MGI Ref ID J:124472]

Chapes SK; Mosier DA; Wright AD; Hart ML. 2001. MHCII, Tlr4 and Nramp1 genes control host pulmonary resistance against the opportunistic bacterium Pasteurella pneumotropica. J Leukoc Biol 69(3):381-6. [PubMed: 11261784]  [MGI Ref ID J:69552]

Chassin C; Goujon JM; Darche S; du Merle L; Bens M; Cluzeaud F; Werts C; Ogier-Denis E; Le Bouguenec C; Buzoni-Gatel D; Vandewalle A. 2006. Renal collecting duct epithelial cells react to pyelonephritis-associated Escherichia coli by activating distinct TLR4-dependent and -independent inflammatory pathways. J Immunol 177(7):4773-84. [PubMed: 16982918]  [MGI Ref ID J:139309]

Chen L; Guo S; Ranzer MJ; DiPietro LA. 2013. Toll-like receptor 4 has an essential role in early skin wound healing. Erratum 2014 page 583 J Invest Dermatol 133(1):258-67. [PubMed: 22951730]  [MGI Ref ID J:196482]

Choi SH; Harkewicz R; Lee JH; Boullier A; Almazan F; Li AC; Witztum JL; Bae YS; Miller YI. 2009. Lipoprotein accumulation in macrophages via toll-like receptor-4-dependent fluid phase uptake. Circ Res 104(12):1355-63. [PubMed: 19461045]  [MGI Ref ID J:164760]

Chung YW; Choi JH; Oh TY; Eun CS; Han DS. 2008. Lactobacillus casei prevents the development of dextran sulphate sodium-induced colitis in Toll-like receptor 4 mutant mice. Clin Exp Immunol 151(1):182-9. [PubMed: 18005362]  [MGI Ref ID J:130145]

Cole BC; Mu HH; Pennock ND; Hasebe A; Chan FV; Washburn LR; Peltier MR. 2005. Isolation and partial purification of macrophage- and dendritic cell-activating components from Mycoplasma arthritidis: association with organism virulence and involvement with Toll-like receptor 2. Infect Immun 73(9):6039-47. [PubMed: 16113324]  [MGI Ref ID J:100413]

Constante M; Wang D; Raymond VA; Bilodeau M; Santos MM. 2007. Repression of repulsive guidance molecule C during inflammation is independent of Hfe and involves tumor necrosis factor-alpha. Am J Pathol 170(2):497-504. [PubMed: 17255318]  [MGI Ref ID J:117889]

Coutinho A; Moller G; Gronowicz E. 1975. Genetical control of B-cell responses. IV. Inheritance of the unresponsiveness to lipopolysaccharides. J Exp Med 142(1):253-8. [PubMed: 1097575]  [MGI Ref ID J:5557]

Cunningham PN; Wang Y; Guo R; He G; Quigg RJ. 2004. Role of Toll-like receptor 4 in endotoxin-induced acute renal failure. J Immunol 172(4):2629-35. [PubMed: 14764737]  [MGI Ref ID J:88059]

Curran CS; Demick KP; Mansfield JM. 2006. Lactoferrin activates macrophages via TLR4-dependent and -independent signaling pathways. Cell Immunol 242(1):23-30. [PubMed: 17034774]  [MGI Ref ID J:116741]

D'Avila H; Melo RC; Parreira GG; Werneck-Barroso E; Castro-Faria-Neto HC; Bozza PT. 2006. Mycobacterium bovis bacillus Calmette-Guerin induces TLR2-mediated formation of lipid bodies: intracellular domains for eicosanoid synthesis in vivo. J Immunol 176(5):3087-97. [PubMed: 16493068]  [MGI Ref ID J:129415]

Da Costa CU; Wantia N; Kirschning CJ; Busch DH; Rodriguez N; Wagner H; Miethke T. 2004. Heat shock protein 60 from Chlamydia pneumoniae elicits an unusual set of inflammatory responses via Toll-like receptor 2 and 4 in vivo. Eur J Immunol 34(10):2874. [PubMed: 15368304]  [MGI Ref ID J:92331]

Dabbagh K; Dahl ME; Stepick-Biek P; Lewis DB. 2002. Toll-like receptor 4 is required for optimal development of Th2 immune responses: role of dendritic cells. J Immunol 168(9):4524-30. [PubMed: 11970998]  [MGI Ref ID J:113992]

De Filippo K; Henderson RB; Laschinger M; Hogg N. 2008. Neutrophil Chemokines KC and Macrophage-Inflammatory Protein-2 Are Newly Synthesized by Tissue Macrophages Using Distinct TLR Signaling Pathways. J Immunol 180(6):4308-15. [PubMed: 18322244]  [MGI Ref ID J:132950]

De Nardo D; Labzin LI; Kono H; Seki R; Schmidt SV; Beyer M; Xu D; Zimmer S; Lahrmann C; Schildberg FA; Vogelhuber J; Kraut M; Ulas T; Kerksiek A; Krebs W; Bode N; Grebe A; Fitzgerald ML; Hernandez NJ; Williams BR; Knolle P; Kneilling M; Rocken M; Lutjohann D; Wright SD; Schultze JL; Latz E. 2014. High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3. Nat Immunol 15(2):152-60. [PubMed: 24317040]  [MGI Ref ID J:209298]

Dear JW; Yasuda H; Hu X; Hieny S; Yuen PS; Hewitt SM; Sher A; Star RA. 2006. Sepsis-induced organ failure is mediated by different pathways in the kidney and liver: acute renal failure is dependent on MyD88 but not renal cell apoptosis. Kidney Int 69(5):832-6. [PubMed: 16518342]  [MGI Ref ID J:136506]

Delano MJ; Kelly-Scumpia KM; Thayer TC; Winfield RD; Scumpia PO; Cuenca AG; Harrington PB; O'Malley KA; Warner E; Gabrilovich S; Mathews CE; Laface D; Heyworth PG; Ramphal R; Strieter RM; Moldawer LL; Efron PA. 2011. Neutrophil mobilization from the bone marrow during polymicrobial sepsis is dependent on CXCL12 signaling. J Immunol 187(2):911-8. [PubMed: 21690321]  [MGI Ref ID J:178027]

Dillon LM; Hida A; Garcia S; Prolla TA; Moraes CT. 2012. Long-term bezafibrate treatment improves skin and spleen phenotypes of the mtDNA mutator mouse. PLoS One 7(9):e44335. [PubMed: 22962610]  [MGI Ref ID J:191639]

Dugan CM; Fullerton AM; Roth RA; Ganey PE. 2011. Natural killer cells mediate severe liver injury in a murine model of halothane hepatitis. Toxicol Sci 120(2):507-18. [PubMed: 21245496]  [MGI Ref ID J:171014]

Dumont F; Barrois R. 1976. Electrokinetic properties of splenic lymphocytes from the low-lipopolysaccharide responder C3H/Hej mice. Folia Biol (Praha) 12(3):145-50. [PubMed: 1086804]  [MGI Ref ID J:5721]

Ehl S; Bischoff R; Ostler T; Vallbracht S; Schulte-Monting J; Poltorak A; Freudenberg M. 2004. The role of Toll-like receptor 4 versus interleukin-12 in immunity to respiratory syncytial virus. Eur J Immunol 34(4):1146-53. [PubMed: 15048726]  [MGI Ref ID J:88878]

Eisenbarth SC; Zhadkevich A; Ranney P; Herrick CA; Bottomly K. 2004. IL-4-dependent Th2 collateral priming to inhaled antigens independent of Toll-like receptor 4 and myeloid differentiation factor 88. J Immunol 172(7):4527-34. [PubMed: 15034070]  [MGI Ref ID J:88724]

Fairweather D; Yusung S; Frisancho S; Barrett M; Gatewood S; Steele R; Rose NR. 2003. IL-12 Receptor beta1 and Toll-Like Receptor 4 Increase IL-1beta- and IL-18-Associated Myocarditis and Coxsackievirus Replication. J Immunol 170(9):4731-7. [PubMed: 12707353]  [MGI Ref ID J:83020]

Fei M; Bhatia S; Oriss TB; Yarlagadda M; Khare A; Akira S; Saijo S; Iwakura Y; Fallert Junecko BA; Reinhart TA; Foreman O; Ray P; Kolls J; Ray A. 2011. TNF-{alpha} from inflammatory dendritic cells (DCs) regulates lung IL-17A/IL-5 levels and neutrophilia versus eosinophilia during persistent fungal infection. Proc Natl Acad Sci U S A 108(13):5360-5. [PubMed: 21402950]  [MGI Ref ID J:171233]

Frendeus B; Godaly G; Hang L; Karpman D; Svanborg C. 2001. Interleukin-8 receptor deficiency confers susceptibility to acute pyelonephritis. J Infect Dis 183 Suppl 1:S56-60. [PubMed: 11171016]  [MGI Ref ID J:120023]

Frink M; Hsieh YC; Thobe BM; Choudhry MA; Schwacha MG; Bland KI; Chaudry IH. 2007. TLR4 regulates Kupffer cell chemokine production, systemic inflammation and lung neutrophil infiltration following trauma-hemorrhage. Mol Immunol 44(10):2625-30. [PubMed: 17239439]  [MGI Ref ID J:118691]

Frisancho-Kiss S; Davis SE; Nyland JF; Frisancho JA; Cihakova D; Barrett MA; Rose NR; Fairweather D. 2007. Cutting edge: cross-regulation by TLR4 and T cell Ig mucin-3 determines sex differences in inflammatory heart disease. J Immunol 178(11):6710-4. [PubMed: 17513715]  [MGI Ref ID J:147853]

Frisard MI; McMillan RP; Marchand J; Wahlberg KA; Wu Y; Voelker KA; Heilbronn L; Haynie K; Muoio B; Li L; Hulver MW. 2010. Toll-like receptor 4 modulates skeletal muscle substrate metabolism. Am J Physiol Endocrinol Metab 298(5):E988-98. [PubMed: 20179247]  [MGI Ref ID J:162884]

Gangloff SC; Zahringer U; Blondin C; Guenounou M; Silver J; Goyert SM. 2005. Influence of CD14 on ligand interactions between lipopolysaccharide and its receptor complex. J Immunol 175(6):3940-5. [PubMed: 16148141]  [MGI Ref ID J:116691]

Ganta RR; Wilkerson MJ; Cheng C; Rokey AM; Chapes SK. 2002. Persistent Ehrlichia chaffeensis infection occurs in the absence of functional major histocompatibility complex class II genes. Infect Immun 70(1):380-8. [PubMed: 11748204]  [MGI Ref ID J:74569]

Gao C; Kozlowska A; Nechaev S; Li H; Zhang Q; Hossain DM; Kowolik CM; Chu P; Swiderski P; Diamond DJ; Pal SK; Raubitschek A; Kortylewski M. 2013. TLR9 signaling in the tumor microenvironment initiates cancer recurrence after radiotherapy. Cancer Res 73(24):7211-21. [PubMed: 24154870]  [MGI Ref ID J:206520]

Geisel J; Kahl F; Muller M; Wagner H; Kirschning CJ; Autenrieth IB; Frick JS. 2007. IL-6 and maturation govern TLR2 and TLR4 induced TLR agonist tolerance and cross-tolerance in dendritic cells. J Immunol 179(9):5811-8. [PubMed: 17947654]  [MGI Ref ID J:153008]

Geisel RE; Sakamoto K; Russell DG; Rhoades ER. 2005. In vivo activity of released cell wall lipids of Mycobacterium bovis bacillus Calmette-Guerin is due principally to trehalose mycolates. J Immunol 174(8):5007-15. [PubMed: 15814731]  [MGI Ref ID J:98152]

Georgel P; Jiang Z; Kunz S; Janssen E; Mols J; Hoebe K; Bahram S; Oldstone MB; Beutler B. 2007. Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway. Virology 362(2):304-13. [PubMed: 17292937]  [MGI Ref ID J:124488]

Giangreco A; Hoste E; Takai Y; Rosewell I; Watt FM. 2012. Epidermal Cadm1 expression promotes autoimmune alopecia via enhanced T cell adhesion and cytotoxicity. J Immunol 188(3):1514-22. [PubMed: 22210910]  [MGI Ref ID J:180748]

Glickstein LJ; Coburn JL. 2006. Short report: Association of macrophage inflammatory response and cell death after in vitro Borrelia burgdorferi infection with arthritis resistance. Am J Trop Med Hyg 75(5):964-7. [PubMed: 17123997]  [MGI Ref ID J:135947]

Goodridge HS; Marshall FA; Else KJ; Houston KM; Egan C; Al-Riyami L; Liew FY; Harnett W; Harnett MM. 2005. Immunomodulation via novel use of TLR4 by the filarial nematode phosphorylcholine-containing secreted product, ES-62. J Immunol 174(1):284-93. [PubMed: 15611251]  [MGI Ref ID J:95856]

Grobner S; Schulz S; Soldanova I; Gunst DS; Waibel M; Wesselborg S; Borgmann S; Autenrieth IB. 2007. Absence of Toll-like receptor 4 signaling results in delayed Yersinia enterocolitica YopP-induced cell death of dendritic cells. Infect Immun 75(1):512-7. [PubMed: 17074859]  [MGI Ref ID J:116649]

Guo S; Al-Sadi R; Said HM; Ma TY. 2013. Lipopolysaccharide Causes an Increase in Intestinal Tight Junction Permeability in Vitro and in Vivo by Inducing Enterocyte Membrane Expression and Localization of TLR-4 and CD14. Am J Pathol 182(2):375-87. [PubMed: 23201091]  [MGI Ref ID J:192566]

Ha H; Lee JH; Kim HN; Kwak HB; Kim HM; Lee SE; Rhee JH; Kim HH; Lee ZH. 2008. Stimulation by TLR5 modulates osteoclast differentiation through STAT1/IFN-beta. J Immunol 180(3):1382-9. [PubMed: 18209032]  [MGI Ref ID J:131353]

Ha T; Li Y; Hua F; Ma J; Gao X; Kelley J; Zhao A; Haddad GE; Williams DL; William Browder I; Kao RL; Li C. 2005. Reduced cardiac hypertrophy in toll-like receptor 4-deficient mice following pressure overload. Cardiovasc Res 68(2):224-34. [PubMed: 15967420]  [MGI Ref ID J:106358]

Han H; Xu W; Headley MB; Jessup HK; Lee KS; Omori M; Comeau MR; Marshak-Rothstein A; Ziegler SF. 2012. Thymic stromal lymphopoietin (TSLP)-mediated dermal inflammation aggravates experimental asthma. Mucosal Immunol 5(3):342-51. [PubMed: 22354320]  [MGI Ref ID J:199558]

Hannan TJ; Mysorekar IU; Hung CS; Isaacson-Schmid ML; Hultgren SJ. 2010. Early severe inflammatory responses to uropathogenic E. coli predispose to chronic and recurrent urinary tract infection. PLoS Pathog 6(8):. [PubMed: 20811584]  [MGI Ref ID J:167926]

Hara K; Iijima K; Elias MK; Seno S; Tojima I; Kobayashi T; Kephart GM; Kurabayashi M; Kita H. 2014. Airway uric acid is a sensor of inhaled protease allergens and initiates type 2 immune responses in respiratory mucosa. J Immunol 192(9):4032-42. [PubMed: 24663677]  [MGI Ref ID J:209984]

Hartwig C; Mazzega M; Constabel H; Krishnaswamy JK; Gessner JE; Braun A; Tschernig T; Behrens GM. 2010. Fcgamma receptor-mediated antigen uptake by lung DC contributes to allergic airway hyper-responsiveness and inflammation. Eur J Immunol 40(5):1284-95. [PubMed: 20148421]  [MGI Ref ID J:160960]

Hasegawa M; Osaka T; Tawaratsumida K; Yamazaki T; Tada H; Chen GY; Tsuneda S; Nunez G; Inohara N. 2010. Transitions in oral and intestinal microflora composition and innate immune receptor-dependent stimulation during mouse development. Infect Immun 78(2):639-50. [PubMed: 19933833]  [MGI Ref ID J:157789]

Hasegawa T; Matsuguchi T; Noda K; Tanaka K; Kumamoto S; Shoyama Y; Yoshikai Y. 2002. Toll-like receptor 2 is at least partly involved in the antitumor activity of glycoprotein from Chlorella vulgaris. Int Immunopharmacol 2(4):579-89. [PubMed: 11962736]  [MGI Ref ID J:76114]

Headley MB; Zhou B; Shih WX; Aye T; Comeau MR; Ziegler SF. 2009. TSLP conditions the lung immune environment for the generation of pathogenic innate and antigen-specific adaptive immune responses. J Immunol 182(3):1641-7. [PubMed: 19155513]  [MGI Ref ID J:144318]

Herter S; Osterloh P; Hilf N; Rechtsteiner G; Hohfeld J; Rammensee HG; Schild H. 2005. Dendritic cell aggresome-like-induced structure formation and delayed antigen presentation coincide in influenza virus-infected dendritic cells. J Immunol 175(2):891-8. [PubMed: 16002687]  [MGI Ref ID J:100719]

Higgins SC; Lavelle EC; McCann C; Keogh B; McNeela E; Byrne P; O'Gorman B; Jarnicki A; McGuirk P; Mills KH. 2003. Toll-like receptor 4-mediated innate IL-10 activates antigen-specific regulatory T cells and confers resistance to Bordetella pertussis by inhibiting inflammatory pathology. J Immunol 171(6):3119-27. [PubMed: 12960338]  [MGI Ref ID J:85389]

Hiratsuka S; Watanabe A; Sakurai Y; Akashi-Takamura S; Ishibashi S; Miyake K; Shibuya M; Akira S; Aburatani H; Maru Y. 2008. The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase. Nat Cell Biol 10(11):1349-55. [PubMed: 18820689]  [MGI Ref ID J:145634]

Hogan MM; Yancey KB; Vogel SN. 1989. Role of C5a in the induction of tumoricidal activity in C3H/HeJ (Lpsd) and C3H/OuJ (Lpsn) macrophages. J Leukoc Biol 46(6):565-70. [PubMed: 2509612]  [MGI Ref ID J:24638]

Holland WL; Bikman BT; Wang LP; Yuguang G; Sargent KM; Bulchand S; Knotts TA; Shui G; Clegg DJ; Wenk MR; Pagliassotti MJ; Scherer PE; Summers SA. 2011. Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice. J Clin Invest 121(5):1858-70. [PubMed: 21490391]  [MGI Ref ID J:173952]

Hollestelle SC; De Vries MR; Van Keulen JK; Schoneveld AH; Vink A; Strijder CF; Van Middelaar BJ; Pasterkamp G; Quax PH; De Kleijn DP. 2004. Toll-like receptor 4 is involved in outward arterial remodeling. Circulation 109(3):393-8. [PubMed: 14699006]  [MGI Ref ID J:101995]

Hollingsworth JW; Whitehead G; Berman KG; Tekippe EM; Gilmour MI; Larkin JE; Quackenbush J; Schwartz DA. 2007. Genetic basis of murine antibacterial defense to streptococcal lung infection. Immunogenetics 59(9):713-24. [PubMed: 17701033]  [MGI Ref ID J:125210]

Hopkins W; Gendron-Fitzpatrick A; McCarthy DO; Haine JE; Uehling DT. 1996. Lipopolysaccharide-responder and nonresponder C3H mouse strains are equally susceptible to an induced Escherichia coli urinary tract infection. Infect Immun 64(4):1369-72. [PubMed: 8606102]  [MGI Ref ID J:33518]

Hopkins WJ; Gendron-Fitzpatrick A; Balish E; Uehling DT. 1998. Time course and host responses to Escherichia coli urinary tract infection in genetically distinct mouse strains. Infect Immun 66(6):2798-802. [PubMed: 9596750]  [MGI Ref ID J:48225]

Hoshino K; Takeuchi O; Kawai T; Sanjo H; Ogawa T; Takeda Y; Takeda K; Akira S. 1999. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol 162(7):3749-52. [PubMed: 10201887]  [MGI Ref ID J:53519]

Hsieh YC; Frink M; Thobe BM; Hsu JT; Choudhry MA; Schwacha MG; Bland KI; Chaudry IH. 2007. 17beta-Estradiol downregulates Kupffer cell TLR4-dependent p38 MAPK pathway and normalizes inflammatory cytokine production following trauma-hemorrhage. Mol Immunol 44(9):2165-72. [PubMed: 17182102]  [MGI Ref ID J:117916]

Hua F; Ha T; Ma J; Li Y; Kelley J; Gao X; Browder IW; Kao RL; Williams DL; Li C. 2007. Protection against myocardial ischemia/reperfusion injury in TLR4-deficient mice is mediated through a phosphoinositide 3-kinase-dependent mechanism. J Immunol 178(11):7317-24. [PubMed: 17513782]  [MGI Ref ID J:147828]

Huang X; Du W; McClellan SA; Barrett RP; Hazlett LD. 2006. TLR4 is required for host resistance in Pseudomonas aeruginosa keratitis. Invest Ophthalmol Vis Sci 47(11):4910-6. [PubMed: 17065506]  [MGI Ref ID J:123090]

Hui W; Jinxiang Z; Heshui W; Zhuoya L; Qichang Z. 2009. Bone marrow and non-bone marrow TLR4 regulates hepatic ischemia/reperfusion injury. Biochem Biophys Res Commun 389(2):328-32. [PubMed: 19723506]  [MGI Ref ID J:153516]

Hutchens MA; Luker KE; Sonstein J; Nunez G; Curtis JL; Luker GD. 2008. Protective effect of Toll-like receptor 4 in pulmonary vaccinia infection. PLoS Pathog 4(9):e1000153. [PubMed: 18802464]  [MGI Ref ID J:162716]

Ignacio-Souza LM; Bombassaro B; Pascoal LB; Portovedo MA; Razolli DS; Coope A; Victorio SC; de Moura RF; Nascimento LF; Arruda AP; Anhe GF; Milanski M; Velloso LA. 2014. Defective regulation of the ubiquitin/proteasome system in the hypothalamus of obese male mice. Endocrinology 155(8):2831-44. [PubMed: 24892821]  [MGI Ref ID J:214459]

Imai Y; Kuba K; Neely GG; Yaghubian-Malhami R; Perkmann T; van Loo G; Ermolaeva M; Veldhuizen R; Leung YH; Wang H; Liu H; Sun Y; Pasparakis M; Kopf M; Mech C; Bavari S; Peiris JS; Slutsky AS; Akira S; Hultqvist M; Holmdahl R; Nicholls J; Jiang C; Binder CJ; Penninger JM. 2008. Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell 133(2):235-49. [PubMed: 18423196]  [MGI Ref ID J:145306]

Ito Y; Kawamura I; Kohda C; Tsuchiya K; Nomura T; Mitsuyama M. 2005. Seeligeriolysin O, a protein toxin of Listeria seeligeri, stimulates macrophage cytokine production via Toll-like receptors in a profile different from that induced by other bacterial ligands. Int Immunol 17(12):1597-606. [PubMed: 16291660]  [MGI Ref ID J:103653]

Jang S; Uematsu S; Akira S; Salgame P. 2004. IL-6 and IL-10 induction from dendritic cells in response to Mycobacterium tuberculosis is predominantly dependent on TLR2-mediated recognition. J Immunol 173(5):3392-7. [PubMed: 15322203]  [MGI Ref ID J:92712]

Jeyaseelan S; Chu HW; Young SK; Freeman MW; Worthen GS. 2005. Distinct roles of pattern recognition receptors CD14 and Toll-like receptor 4 in acute lung injury. Infect Immun 73(3):1754-63. [PubMed: 15731076]  [MGI Ref ID J:96680]

Jilling T; Simon D; Lu J; Meng FJ; Li D; Schy R; Thomson RB; Soliman A; Arditi M; Caplan MS. 2006. The roles of bacteria and TLR4 in rat and murine models of necrotizing enterocolitis. J Immunol 177(5):3273-82. [PubMed: 16920968]  [MGI Ref ID J:139539]

Jin JJ; Kim HD; Maxwell JA; Li L; Fukuchi K. 2008. Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease. J Neuroinflammation 5:23. [PubMed: 18510752]  [MGI Ref ID J:174833]

John B; Crispe IN. 2005. TLR-4 regulates CD8+ T cell trapping in the liver. J Immunol 175(3):1643-50. [PubMed: 16034104]  [MGI Ref ID J:107284]

Johnson DR; O'Connor JC; Hartman ME; Tapping RI; Freund GG. 2007. Acute hypoxia activates the neuroimmune system, which diabetes exacerbates. J Neurosci 27(5):1161-6. [PubMed: 17267571]  [MGI Ref ID J:117904]

Johnson GB; Riggs BL; Platt JL. 2004. A genetic basis for the 'Adonis' phenotype of low adiposity and strong bones. FASEB J 18(11):1282-4. [PubMed: 15208271]  [MGI Ref ID J:118467]

Jordan JM; Woods ME; Olano J; Walker DH. 2008. The absence of Toll-like receptor 4 signaling in C3H/HeJ mice predisposes them to overwhelming rickettsial infection and decreased protective Th1 responses. Infect Immun 76(8):3717-24. [PubMed: 18490467]  [MGI Ref ID J:139397]

Jude BA; Pobezinskaya Y; Bishop J; Parke S; Medzhitov RM; Chervonsky AV; Golovkina TV. 2003. Subversion of the innate immune system by a retrovirus. Nat Immunol 4(6):573-8. [PubMed: 12730691]  [MGI Ref ID J:83088]

Jung DY; Lee H; Jung BY; Ock J; Lee MS; Lee WH; Suk K. 2005. TLR4, but not TLR2, signals autoregulatory apoptosis of cultured microglia: a critical role of IFN-beta as a decision maker. J Immunol 174(10):6467-76. [PubMed: 15879150]  [MGI Ref ID J:99051]

Jung YW; Schoeb TR; Weaver CT; Chaplin DD. 2006. Antigen and lipopolysaccharide play synergistic roles in the effector phase of airway inflammation in mice. Am J Pathol 168(5):1425-34. [PubMed: 16651610]  [MGI Ref ID J:108686]

Juskewitch JE; Knudsen BE; Platt JL; Nath KA; Knutson KL; Brunn GJ; Grande JP. 2012. LPS-induced murine systemic inflammation is driven by parenchymal cell activation and exclusively predicted by early MCP-1 plasma levels. Am J Pathol 180(1):32-40. [PubMed: 22067909]  [MGI Ref ID J:180166]

Kallberg E; Vogl T; Liberg D; Olsson A; Bjork P; Wikstrom P; Bergh A; Roth J; Ivars F; Leanderson T. 2012. S100A9 interaction with TLR4 promotes tumor growth. PLoS One 7(3):e34207. [PubMed: 22470535]  [MGI Ref ID J:187129]

Kampfrath T; Maiseyeu A; Ying Z; Shah Z; Deiuliis JA; Xu X; Kherada N; Brook RD; Reddy KM; Padture NP; Parthasarathy S; Chen LC; Moffatt-Bruce S; Sun Q; Morawietz H; Rajagopalan S. 2011. Chronic fine particulate matter exposure induces systemic vascular dysfunction via NADPH oxidase and TLR4 pathways. Circ Res 108(6):716-26. [PubMed: 21273555]  [MGI Ref ID J:183599]

Kang S; Lee SP; Kim KE; Kim HZ; Memet S; Koh GY. 2009. Toll-like receptor 4 in lymphatic endothelial cells contributes to LPS-induced lymphangiogenesis by chemotactic recruitment of macrophages. Blood 113(11):2605-13. [PubMed: 19098273]  [MGI Ref ID J:146303]

Kang TH; Mao CP; Lee SY; Chen A; Lee JH; Kim TW; Alvarez RD; Roden RB; Pardoll D; Hung CF; Wu TC. 2013. Chemotherapy acts as an adjuvant to convert the tumor microenvironment into a highly permissive state for vaccination-induced antitumor immunity. Cancer Res 73(8):2493-504. [PubMed: 23418322]  [MGI Ref ID J:196970]

Karper JC; de Vries MR; van den Brand BT; Hoefer IE; Fischer JW; Jukema JW; Niessen HW; Quax PH. 2011. Toll-like receptor 4 is involved in human and mouse vein graft remodeling, and local gene silencing reduces vein graft disease in hypercholesterolemic APOE*3Leiden mice. Arterioscler Thromb Vasc Biol 31(5):1033-40. [PubMed: 21330606]  [MGI Ref ID J:191490]

Karst SY; Ward-Bailey PF; Donahue LR; Johnson KR; Davisson MT. 2007. Ruby eye 2-like (Ru2l): a new spontaneous mutation causing a light coat color and red eyes MGI Direct Data Submission :.  [MGI Ref ID J:123265]

Katz J; Zhang P; Martin M; Vogel SN; Michalek SM. 2006. Toll-like receptor 2 is required for inflammatory responses to Francisella tularensis LVS. Infect Immun 74(5):2809-16. [PubMed: 16622218]  [MGI Ref ID J:108092]

Kerepesi LA; Leon O; Lustigman S; Abraham D. 2005. Protective immunity to the larval stages of onchocerca volvulus is dependent on Toll-like receptor 4. Infect Immun 73(12):8291-7. [PubMed: 16299326]  [MGI Ref ID J:104303]

Khan MA; Ma C; Knodler LA; Valdez Y; Rosenberger CM; Deng W; Finlay BB; Vallance BA. 2006. Toll-like receptor 4 contributes to colitis development but not to host defense during Citrobacter rodentium infection in mice. Infect Immun 74(5):2522-36. [PubMed: 16622187]  [MGI Ref ID J:108095]

Kigerl KA; Lai W; Rivest S; Hart RP; Satoskar AR; Popovich PG. 2007. Toll-like receptor (TLR)-2 and TLR-4 regulate inflammation, gliosis, and myelin sparing after spinal cord injury. J Neurochem 102(1):37-50. [PubMed: 17403033]  [MGI Ref ID J:122597]

Kilic U; Kilic E; Matter CM; Bassetti CL; Hermann DM. 2008. TLR-4 deficiency protects against focal cerebral ischemia and axotomy-induced neurodegeneration. Neurobiol Dis 31(1):33-40. [PubMed: 18486483]  [MGI Ref ID J:138382]

Kim HS; Han MS; Chung KW; Kim S; Kim E; Kim MJ; Jang E; Lee HA; Youn J; Akira S; Lee MS. 2007. Toll-like Receptor 2 Senses beta-Cell Death and Contributes to the Initiation of Autoimmune Diabetes. Immunity 27(2):321-33. [PubMed: 17707128]  [MGI Ref ID J:124334]

Kin NW; Sanders VM. 2006. CD86 stimulation on a B cell activates the phosphatidylinositol 3-kinase/Akt and phospholipase C gamma 2/protein kinase C alpha beta signaling pathways. J Immunol 176(11):6727-35. [PubMed: 16709832]  [MGI Ref ID J:131798]

Kirimanjeswara GS; Mann PB; Pilione M; Kennett MJ; Harvill ET. 2005. The complex mechanism of antibody-mediated clearance of Bordetella from the lungs requires TLR4. J Immunol 175(11):7504-11. [PubMed: 16301658]  [MGI Ref ID J:122156]

Kleeberger SR; Reddy SP; Zhang LY; Cho HY; Jedlicka AE. 2001. Toll-like receptor 4 mediates ozone-induced murine lung hyperpermeability via inducible nitric oxide synthase. Am J Physiol Lung Cell Mol Physiol 280(2):L326-33. [PubMed: 11159012]  [MGI Ref ID J:108671]

Koedel U; Angele B; Rupprecht T; Wagner H; Roggenkamp A; Pfister HW; Kirschning CJ. 2003. Toll-like receptor 2 participates in mediation of immune response in experimental pneumococcal meningitis. J Immunol 170(1):438-44. [PubMed: 12496429]  [MGI Ref ID J:127283]

Koga T; Lim JH; Jono H; Ha UH; Xu H; Ishinaga H; Morino S; Xu X; Yan C; Kai H; Li JD. 2008. Tumor suppressor cylindromatosis acts as a negative regulator for Streptococcus pneumoniae-induced NFAT signaling. J Biol Chem 283(18):12546-54. [PubMed: 18332137]  [MGI Ref ID J:136838]

Kolli D; Bao X; Liu T; Hong C; Wang T; Garofalo RP; Casola A. 2011. Human metapneumovirus glycoprotein G inhibits TLR4-dependent signaling in monocyte-derived dendritic cells. J Immunol 187(1):47-54. [PubMed: 21632720]  [MGI Ref ID J:176038]

Komai-Koma M; Gilchrist DS; Xu D. 2009. Direct recognition of LPS by human but not murine CD8+ T cells via TLR4 complex. Eur J Immunol 39(6):1564-72. [PubMed: 19405031]  [MGI Ref ID J:149561]

Komura H; Miksa M; Wu R; Goyert SM; Wang P. 2009. Milk fat globule epidermal growth factor-factor VIII is down-regulated in sepsis via the lipopolysaccharide-CD14 pathway. J Immunol 182(1):581-7. [PubMed: 19109191]  [MGI Ref ID J:142885]

Kozak W; Wrotek S; Kozak A. 2006. Pyrogenicity of CpG-DNA in mice: role of interleukin-6, cyclooxygenases, and nuclear factor-kappaB. Am J Physiol Regul Integr Comp Physiol 290(4):R871-80. [PubMed: 16293680]  [MGI Ref ID J:115760]

Kupz A; Guarda G; Gebhardt T; Sander LE; Short KR; Diavatopoulos DA; Wijburg OL; Cao H; Waithman JC; Chen W; Fernandez-Ruiz D; Whitney PG; Heath WR; Curtiss R 3rd; Tschopp J; Strugnell RA; Bedoui S. 2012. NLRC4 inflammasomes in dendritic cells regulate noncognate effector function by memory CD8 T cells. Nat Immunol 13(2):162-9. [PubMed: 22231517]  [MGI Ref ID J:181212]

Laird MH; Rhee SH; Perkins DJ; Medvedev AE; Piao W; Fenton MJ; Vogel SN. 2009. TLR4/MyD88/PI3K interactions regulate TLR4 signaling. J Leukoc Biol 85(6):966-77. [PubMed: 19289601]  [MGI Ref ID J:149619]

Lange S; Delbro DS; Jennische E; Mattsby-Baltzer I. 1996. The role of the Lps gene in experimental ulcerative colitis in mice. APMIS 104(11):823-33. [PubMed: 8982246]  [MGI Ref ID J:37271]

Laskin DL; Chen L; Hankey PA; Laskin JD. 2010. Role of STK in mouse liver macrophage and endothelial cell responsiveness during acute endotoxemia. J Leukoc Biol 88(2):373-82. [PubMed: 20453108]  [MGI Ref ID J:163944]

Lee EK; Kang SM; Paik DJ; Kim JM; Youn J. 2005. Essential roles of Toll-like receptor-4 signaling in arthritis induced by type II collagen antibody and LPS. Int Immunol 17(3):325-33. [PubMed: 15684036]  [MGI Ref ID J:96356]

Lee JS; Frevert CW; Matute-Bello G; Wurfel MM; Wong VA; Lin SM; Ruzinski J; Mongovin S; Goodman RB; Martin TR. 2005. TLR-4 pathway mediates the inflammatory response but not bacterial elimination in E. coli pneumonia. Am J Physiol Lung Cell Mol Physiol 289(5):L731-8. [PubMed: 16024722]  [MGI Ref ID J:115440]

Lee K; Hwang S; Paik DJ; Kim WK; Kim JM; Youn J. 2012. Bacillus-derived poly-gamma-glutamic acid reciprocally regulates the differentiation of T helper 17 and regulatory T cells and attenuates experimental autoimmune encephalomyelitis. Clin Exp Immunol 170(1):66-76. [PubMed: 22943202]  [MGI Ref ID J:188286]

Lee SJ; Kang JH; Choi SY; Suk KT; Kim DJ; Kwon OS. 2013. PKCdelta as a regulator for TGFbeta1-induced alpha-SMA production in a murine nonalcoholic steatohepatitis model. PLoS One 8(2):e55979. [PubMed: 23441159]  [MGI Ref ID J:199411]

Lehnardt S; Henneke P; Lien E; Kasper DL; Volpe JJ; Bechmann I; Nitsch R; Weber JR; Golenbock DT; Vartanian T. 2006. A mechanism for neurodegeneration induced by group B streptococci through activation of the TLR2/MyD88 pathway in microglia. J Immunol 177(1):583-92. [PubMed: 16785556]  [MGI Ref ID J:134437]

Lehnardt S; Lachance C; Patrizi S; Lefebvre S; Follett PL; Jensen FE; Rosenberg PA; Volpe JJ; Vartanian T. 2002. The toll-like receptor TLR4 is necessary for lipopolysaccharide-induced oligodendrocyte injury in the CNS. J Neurosci 22(7):2478-86. [PubMed: 11923412]  [MGI Ref ID J:109244]

Leite-de-Moraes MC; Herbelin A; Gombert JM; Vicari A; Papiernik M ; Dy M. 1997. Requirement of IL-7 for IL-4-producing potential of MHC class I-selected CD4-CD8-TCR alpha beta+ thymocytes. Int Immunol 9(1):73-9. [PubMed: 9043949]  [MGI Ref ID J:40708]

Leng CH; Chen HW; Chang LS; Liu HH; Liu HY; Sher YP; Chang YW; Lien SP; Huang TY; Chen MY; Chou AH; Chong P; Liu SJ. 2010. A recombinant lipoprotein containing an unsaturated fatty acid activates NF-kappaB through the TLR2 signaling pathway and induces a differential gene profile from a synthetic lipopeptide. Mol Immunol :. [PubMed: 20478617]  [MGI Ref ID J:160689]

Levy RM; Prince JM; Yang R; Mollen KP; Liao H; Watson GA; Fink MP; Vodovotz Y; Billiar TR. 2006. Systemic inflammation and remote organ damage following bilateral femur fracture requires Toll-like receptor 4. Am J Physiol Regul Integr Comp Physiol 291(4):R970-6. [PubMed: 16675630]  [MGI Ref ID J:144408]

Li H; Nookala S; Bina XR; Bina JE; Re F. 2006. Innate immune response to Francisella tularensis is mediated by TLR2 and caspase-1 activation. J Leukoc Biol 80(4):766-73. [PubMed: 16895974]  [MGI Ref ID J:113031]

Li Q; Cherayil BJ. 2004. Toll-like receptor 4 mutation impairs the macrophage TNFalpha response to peptidoglycan. Biochem Biophys Res Commun 325(1):91-6. [PubMed: 15522205]  [MGI Ref ID J:93526]

Liang CF; Liu JT; Wang Y; Xu A; Vanhoutte PM. 2013. Toll-like receptor 4 mutation protects obese mice against endothelial dysfunction by decreasing NADPH oxidase isoforms 1 and 4. Arterioscler Thromb Vasc Biol 33(4):777-84. [PubMed: 23413427]  [MGI Ref ID J:217972]

Liang Y; Ma S; Zhang Y; Wang Y; Cheng Q; Wu Y; Jin Y; Zheng D; Wu D; Liu H. 2014. IL-1beta and TLR4 signaling are involved in the aggravated murine acute graft-versus-host disease caused by delayed bortezomib administration. J Immunol 192(3):1277-85. [PubMed: 24363427]  [MGI Ref ID J:207316]

Liu H; Redline RW; Han YW. 2007. Fusobacterium nucleatum induces fetal death in mice via stimulation of TLR4-mediated placental inflammatory response. J Immunol 179(4):2501-8. [PubMed: 17675512]  [MGI Ref ID J:151289]

Liu S; Kielian T. 2009. Microglial activation by Citrobacter koseri is mediated by TLR4- and MyD88-dependent pathways. J Immunol 183(9):5537-47. [PubMed: 19812209]  [MGI Ref ID J:156619]

Liu Y; Yuan Y; Li Y; Zhang J; Xiao G; Vodovotz Y; Billiar TR; Wilson MA; Fan J. 2009. Interacting neuroendocrine and innate and acquired immune pathways regulate neutrophil mobilization from bone marrow following hemorrhagic shock. J Immunol 182(1):572-80. [PubMed: 19109190]  [MGI Ref ID J:142886]

Looney MR; Nguyen JX; Hu Y; Van Ziffle JA; Lowell CA; Matthay MA. 2009. Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury. J Clin Invest 119(11):3450-61. [PubMed: 19809160]  [MGI Ref ID J:154615]

Loser K; Vogl T; Voskort M; Lueken A; Kupas V; Nacken W; Klenner L; Kuhn A; Foell D; Sorokin L; Luger TA; Roth J; Beissert S. 2010. The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cells. Nat Med 16(6):713-7. [PubMed: 20473308]  [MGI Ref ID J:161530]

Loures FV; Pina A; Felonato M; Araujo EF; Leite KR; Calich VL. 2010. Toll-like receptor 4 signaling leads to severe fungal infection associated with enhanced proinflammatory immunity and impaired expansion of regulatory T cells. Infect Immun 78(3):1078-88. [PubMed: 20008536]  [MGI Ref ID J:157774]

Mahieu T; Park JM; Revets H; Pasche B; Lengeling A; Staelens J; Wullaert A; Vanlaere I; Hochepied T; van Roy F; Karin M; Libert C. 2006. The wild-derived inbred mouse strain SPRET/Ei is resistant to LPS and defective in IFN-beta production. Proc Natl Acad Sci U S A 103(7):2292-7. [PubMed: 16455798]  [MGI Ref ID J:106066]

Malley R; Henneke P; Morse SC; Cieslewicz MJ; Lipsitch M; Thompson CM; Kurt-Jones E; Paton JC; Wessels MR; Golenbock DT. 2003. Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection. Proc Natl Acad Sci U S A 100(4):1966-71. [PubMed: 12569171]  [MGI Ref ID J:81975]

Mann PB; Elder KD; Kennett MJ; Harvill ET. 2004. Toll-like receptor 4-dependent early elicited tumor necrosis factor alpha expression is critical for innate host defense against Bordetella bronchiseptica. Infect Immun 72(11):6650-8. [PubMed: 15501798]  [MGI Ref ID J:93263]

Mann PB; Kennett MJ; Harvill ET. 2004. Toll-like receptor 4 is critical to innate host defense in a murine model of bordetellosis. J Infect Dis 189(5):833-6. [PubMed: 14976600]  [MGI Ref ID J:88587]

Mann PB; Wolfe D; Latz E; Golenbock D; Preston A; Harvill ET. 2005. Comparative toll-like receptor 4-mediated innate host defense to Bordetella infection. Infect Immun 73(12):8144-52. [PubMed: 16299309]  [MGI Ref ID J:104298]

Maroso M; Balosso S; Ravizza T; Liu J; Aronica E; Iyer AM; Rossetti C; Molteni M; Casalgrandi M; Manfredi AA; Bianchi ME; Vezzani A. 2010. Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures. Nat Med 16(4):413-9. [PubMed: 20348922]  [MGI Ref ID J:159308]

Mattioli TA; Leduc-Pessah H; Skelhorne-Gross G; Nicol CJ; Milne B; Trang T; Cahill CM. 2014. Toll-like receptor 4 mutant and null mice retain morphine-induced tolerance, hyperalgesia, and physical dependence. PLoS One 9(5):e97361. [PubMed: 24824631]  [MGI Ref ID J:216345]

McCartney-Francis N; Jin W; Wahl SM. 2004. Aberrant Toll receptor expression and endotoxin hypersensitivity in mice lacking a functional TGF-beta 1 signaling pathway. J Immunol 172(6):3814-21. [PubMed: 15004187]  [MGI Ref ID J:88604]

Medoff BD; Wain JC; Seung E; Jackobek R; Means TK; Ginns LC; Farber JM; Luster AD. 2006. CXCR3 and its ligands in a murine model of obliterative bronchiolitis: regulation and function. J Immunol 176(11):7087-95. [PubMed: 16709871]  [MGI Ref ID J:131767]

Meng X; Ao L; Song Y; Raeburn CD; Fullerton DA; Harken AH. 2005. Signaling for myocardial depression in hemorrhagic shock: roles of Toll-like receptor 4 and p55 TNF-alpha receptor. Am J Physiol Regul Integr Comp Physiol 288(3):R600-6. [PubMed: 15514106]  [MGI Ref ID J:96316]

Milanski M; Arruda AP; Coope A; Ignacio-Souza LM; Nunez CE; Roman EA; Romanatto T; Pascoal LB; Caricilli AM; Torsoni MA; Prada PO; Saad MJ; Velloso LA. 2012. Inhibition of hypothalamic inflammation reverses diet-induced insulin resistance in the liver. Diabetes 61(6):1455-62. [PubMed: 22522614]  [MGI Ref ID J:196822]

Mishra PK; Wu W; Rozo C; Hallab NJ; Benevenia J; Gause WC. 2011. Micrometer-sized titanium particles can induce potent Th2-type responses through TLR4-independent pathways. J Immunol 187(12):6491-8. [PubMed: 22095717]  [MGI Ref ID J:180376]

Moayeri M; Martinez NW; Wiggins J; Young HA; Leppla SH. 2004. Mouse susceptibility to anthrax lethal toxin is influenced by genetic factors in addition to those controlling macrophage sensitivity. Infect Immun 72(8):4439-47. [PubMed: 15271901]  [MGI Ref ID J:91775]

Mollen KP; Levy RM; Prince JM; Hoffman RA; Scott MJ; Kaczorowski DJ; Vallabhaneni R; Vodovotz Y; Billiar TR. 2008. Systemic inflammation and end organ damage following trauma involves functional TLR4 signaling in both bone marrow-derived cells and parenchymal cells. J Leukoc Biol 83(1):80-8. [PubMed: 17925504]  [MGI Ref ID J:130089]

Monteiro AC; Schmitz V; Svensjo E; Gazzinelli RT; Almeida IC; Todorov A; de Arruda LB; Torrecilhas AC; Pesquero JB; Morrot A; Bouskela E; Bonomo A; Lima AP; Muller-Esterl W; Scharfstein J. 2006. Cooperative activation of TLR2 and bradykinin B2 receptor is required for induction of type 1 immunity in a mouse model of subcutaneous infection by Trypanosoma cruzi. J Immunol 177(9):6325-35. [PubMed: 17056563]  [MGI Ref ID J:140513]

Moreth K; Brodbeck R; Babelova A; Gretz N; Spieker T; Zeng-Brouwers J; Pfeilschifter J; Young MF; Schaefer RM; Schaefer L. 2010. The proteoglycan biglycan regulates expression of the B cell chemoattractant CXCL13 and aggravates murine lupus nephritis. J Clin Invest 120(12):4251-72. [PubMed: 21084753]  [MGI Ref ID J:171866]

Mortaz E; Redegeld FA; Nijkamp FP; Wong HR; Engels F. 2006. Acetylsalicylic acid-induced release of HSP70 from mast cells results in cell activation through TLR pathway. Exp Hematol 34(1):8-18. [PubMed: 16413386]  [MGI Ref ID J:104576]

Moses T; Wagner L; Fleming SD. 2009. TLR4-mediated Cox-2 expression increases intestinal ischemia/reperfusion-induced damage. J Leukoc Biol 86(4):971-80. [PubMed: 19564573]  [MGI Ref ID J:153441]

Mottillo EP; Shen XJ; Granneman JG. 2007. Role of hormone-sensitive lipase in beta-adrenergic remodeling of white adipose tissue. Am J Physiol Endocrinol Metab 293(5):E1188-97. [PubMed: 17711991]  [MGI Ref ID J:126761]

Mu HH; Sawitzke AD; Cole BC. 2001. Presence of Lps(d) mutation influences cytokine regulation in vivo by the Mycoplasma arthritidis mitogen superantigen and lethal toxicity in mice infected with M. arthritidis. Infect Immun 69(6):3837-44. [PubMed: 11349049]  [MGI Ref ID J:69541]

Mueller M; Postius S; Thimm JG; Gueinzius K; Muehldorfer I; Hermann C. 2004. Toll-like receptors 2 and 4 do not contribute to clearance of Chlamydophila pneumoniae in mice, but are necessary for the release of monokines. Immunobiology 209(8):599-608. [PubMed: 15638128]  [MGI Ref ID J:101915]

Naseemuddin M; Iqbal A; Nasti TH; Ghandhi JL; Kapadia AD; Yusuf N. 2012. Cell mediated immune responses through TLR4 prevents DMBA-induced mammary carcinogenesis in mice. Int J Cancer 130(4):765-74. [PubMed: 21455984]  [MGI Ref ID J:181012]

Neal MD; Leaphart C; Levy R; Prince J; Billiar TR; Watkins S; Li J; Cetin S; Ford H; Schreiber A; Hackam DJ. 2006. Enterocyte TLR4 mediates phagocytosis and translocation of bacteria across the intestinal barrier. J Immunol 176(5):3070-9. [PubMed: 16493066]  [MGI Ref ID J:129416]

Netea MG; Van Der Graaf CA; Vonk AG; Verschueren I; Van Der Meer JW; Kullberg BJ. 2002. The role of toll-like receptor (TLR) 2 and TLR4 in the host defense against disseminated candidiasis. J Infect Dis 185(10):1483-9. [PubMed: 11992285]  [MGI Ref ID J:126008]

Nishikubo K; Imanaka-Yoshida K; Tamaki S; Hiroe M; Yoshida T; Adachi Y; Yasutomi Y. 2007. Th1-type immune responses by Toll-like receptor 4 signaling are required for the development of myocarditis in mice with BCG-induced myocarditis. J Autoimmun 29(2-3):146-53. [PubMed: 17698322]  [MGI Ref ID J:125182]

Nolte MA; Leibundgut-Landmann S; Joffre O; Reis e Sousa C. 2007. Dendritic cell quiescence during systemic inflammation driven by LPS stimulation of radioresistant cells in vivo. J Exp Med 204(6):1487-501. [PubMed: 17548522]  [MGI Ref ID J:125853]

O'Brien AD; Weinstein DA; Soliman MY; Rosenstreich DL. 1985. Additional evidence that the Lps gene locus regulates natural resistance to S. typhimurium in mice. J Immunol 134(5):2820-3. [PubMed: 3884708]  [MGI Ref ID J:7783]

Ochoa-Cortes F; Ramos-Lomas T; Miranda-Morales M; Spreadbury I; Ibeakanma C; Barajas-Lopez C; Vanner S. 2010. Bacterial cell products signal to mouse colonic nociceptive dorsal root ganglia neurons. Am J Physiol Gastrointest Liver Physiol 299(3):G723-32. [PubMed: 20576919]  [MGI Ref ID J:163333]

Ogawa A; Tagawa T; Nishimura H; Yajima T; Abe T; Arai T; Taniguchi M; Takeda K; Akira S; Nimura Y; Yoshikai Y. 2006. Toll-like receptors 2 and 4 are differentially involved in Fas dependent apoptosis in Peyer's patch and the liver at an early stage after bile duct ligation in mice. Gut 55(1):105-13. [PubMed: 16118350]  [MGI Ref ID J:135830]

Oh GS; Kim HJ; Choi JH; Shen A; Kim CH; Kim SJ; Shin SR; Hong SH; Kim Y; Park C; Lee SJ; Akira S; Park R; So HS. 2011. Activation of lipopolysaccharide-TLR4 signaling accelerates the ototoxic potential of cisplatin in mice. J Immunol 186(2):1140-50. [PubMed: 21148032]  [MGI Ref ID J:168789]

Ohashi K; Burkart V; Flohe S; Kolb H. 2000. Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J Immunol 164(2):558-61. [PubMed: 10623794]  [MGI Ref ID J:59296]

Oliveira AC; Peixoto JR; de Arruda LB; Campos MA; Gazzinelli RT; Golenbock DT; Akira S; Previato JO; Mendonca-Previato L; Nobrega A; Bellio M. 2004. Expression of functional TLR4 confers proinflammatory responsiveness to Trypanosoma cruzi glycoinositolphospholipids and higher resistance to infection with T. cruzi. J Immunol 173(9):5688-96. [PubMed: 15494520]  [MGI Ref ID J:93767]

Oyama J; Blais C Jr; Liu X; Pu M; Kobzik L; Kelly RA; Bourcier T. 2004. Reduced myocardial ischemia-reperfusion injury in toll-like receptor 4-deficient mice. Circulation 109(6):784-9. [PubMed: 14970116]  [MGI Ref ID J:102150]

Pacheco P; Vieira-de-Abreu A; Gomes RN; Barbosa-Lima G; Wermelinger LB; Maya-Monteiro CM; Silva AR; Bozza MT; Castro-Faria-Neto HC; Bandeira-Melo C; Bozza PT. 2007. Monocyte chemoattractant protein-1/CC chemokine ligand 2 controls microtubule-driven biogenesis and leukotriene B4-synthesizing function of macrophage lipid bodies elicited by innate immune response. J Immunol 179(12):8500-8. [PubMed: 18056397]  [MGI Ref ID J:155194]

Palliser D; Huang Q; Hacohen N; Lamontagne SP; Guillen E; Young RA; Eisen HN. 2004. A role for Toll-like receptor 4 in dendritic cell activation and cytolytic CD8+ T cell differentiation in response to a recombinant heat shock fusion protein. J Immunol 172(5):2885-93. [PubMed: 14978090]  [MGI Ref ID J:88229]

Park JE; Kim YI; Yi AK. 2009. Protein kinase D1 is essential for MyD88-dependent TLR signaling pathway. J Immunol 182(10):6316-27. [PubMed: 19414785]  [MGI Ref ID J:148236]

Patnode ML; Bando JK; Krummel MF; Locksley RM; Rosen SD. 2014. Leukotriene B4 amplifies eosinophil accumulation in response to nematodes. J Exp Med 211(7):1281-8. [PubMed: 24889202]  [MGI Ref ID J:214462]

Patole PS; Schubert S; Hildinger K; Khandoga S; Khandoga A; Segerer S; Henger A; Kretzler M; Werner M; Krombach F; Schlondorff D; Anders HJ. 2005. Toll-like receptor-4: renal cells and bone marrow cells signal for neutrophil recruitment during pyelonephritis. Kidney Int 68(6):2582-7. [PubMed: 16316333]  [MGI Ref ID J:116903]

Peyssonnaux C; Zinkernagel AS; Datta V; Lauth X; Johnson RS; Nizet V. 2006. TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens. Blood 107(9):3727-32. [PubMed: 16391018]  [MGI Ref ID J:132558]

Pierer M; Wagner U; Rossol M; Ibrahim S. 2011. Toll-like receptor 4 is involved in inflammatory and joint destructive pathways in collagen-induced arthritis in DBA1J mice. PLoS One 6(8):e23539. [PubMed: 21858160]  [MGI Ref ID J:176361]

Poltorak A; He X; Smirnova I; Liu MY; Huffel CV; Du X; Birdwell D; Alejos E; Silva M; Galanos C; Freudenberg M; Ricciardi-Castagnoli P; Layton B; Beutler B. 1998. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282(5396):2085-8. [PubMed: 9851930]  [MGI Ref ID J:51522]

Popovic ZV; Wang S; Papatriantafyllou M; Kaya Z; Porubsky S; Meisner M; Bonrouhi M; Burgdorf S; Young MF; Schaefer L; Grone HJ. 2011. The proteoglycan biglycan enhances antigen-specific T cell activation potentially via MyD88 and TRIF pathways and triggers autoimmune perimyocarditis. J Immunol 187(12):6217-26. [PubMed: 22095710]  [MGI Ref ID J:180379]

Prince LS; Okoh VO; Moninger TO; Matalon S. 2004. Lipopolysaccharide increases alveolar type II cell number in fetal mouse lungs through Toll-like receptor 4 and NF-kappaB. Am J Physiol Lung Cell Mol Physiol 287(5):L999-1006. [PubMed: 15475494]  [MGI Ref ID J:98217]

Qureshi ST; Gros P; Malo D. 1999. The Lps locus: genetic regulation of host responses to bacterial lipopolysaccharide Inflamm Res 48(12):613-20. [PubMed: 10669111]  [MGI Ref ID J:60495]

Qureshi ST; Lariviere L; Leveque G; Clermont S; Moore KJ; Gros P ; Malo D. 1999. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4) [see comments] J Exp Med 189(4):615-25. [PubMed: 9989976]  [MGI Ref ID J:53343]

Rafi A; Nagarkatti M; Nagarkatti PS. 1997. Hyaluronate-CD44 interactions can induce murine B-cell activation. Blood 89(8):2901-8. [PubMed: 9108410]  [MGI Ref ID J:39824]

Rathinam VA; Appledorn DM; Hoag KA; Amalfitano A; Mansfield LS. 2009. Campylobacter jejuni-induced activation of dendritic cells involves cooperative signaling through Toll-like receptor 4 (TLR4)-MyD88 and TLR4-TRIF axes. Infect Immun 77(6):2499-507. [PubMed: 19332531]  [MGI Ref ID J:149359]

Redecha P; Tilley R; Tencati M; Salmon JE; Kirchhofer D; Mackman N; Girardi G. 2007. Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody induced fetal injury. Blood 110(7):2423-31. [PubMed: 17536017]  [MGI Ref ID J:147022]

Reese TA; Liang HE; Tager AM; Luster AD; Van Rooijen N; Voehringer D; Locksley RM. 2007. Chitin induces accumulation in tissue of innate immune cells associated with allergy. Nature 447(7140):92-6. [PubMed: 17450126]  [MGI Ref ID J:122735]

Reiling N; Holscher C; Fehrenbach A; Kroger S; Kirschning CJ; Goyert S; Ehlers S. 2002. Cutting edge: Toll-like receptor (TLR)2- and TLR4-mediated pathogen recognition in resistance to airborne infection with Mycobacterium tuberculosis. J Immunol 169(7):3480-4. [PubMed: 12244136]  [MGI Ref ID J:120386]

Reino DC; Pisarenko V; Palange D; Doucet D; Bonitz RP; Lu Q; Colorado I; Sheth SU; Chandler B; Kannan KB; Ramanathan M; Xu da Z; Deitch EA; Feinman R. 2011. Trauma hemorrhagic shock-induced lung injury involves a gut-lymph-induced TLR4 pathway in mice. PLoS One 6(8):e14829. [PubMed: 21829592]  [MGI Ref ID J:176529]

Reynolds JM; Martinez GJ; Chung Y; Dong C. 2012. Toll-like receptor 4 signaling in T cells promotes autoimmune inflammation. Proc Natl Acad Sci U S A 109(32):13064-9. [PubMed: 22826216]  [MGI Ref ID J:188488]

Rico MA; Infantes S; Ramos M; Trento A; Johnstone C; Melero JA; Del Val M; Lopez D. 2010. TLR4-independent upregulation of activation markers in mouse B lymphocytes infected by HRSV. Mol Immunol 47(9):1802-7. [PubMed: 20362337]  [MGI Ref ID J:160628]

Riehl TE; Foster L; Stenson WF. 2012. Hyaluronic acid is radioprotective in the intestine through a TLR4 and COX-2-mediated mechanism. Am J Physiol Gastrointest Liver Physiol 302(3):G309-16. [PubMed: 22038822]  [MGI Ref ID J:183323]

Robays LJ; Lanckacker EA; Moerloose KB; Maes T; Bracke KR; Brusselle GG; Joos GF; Vermaelen KY. 2009. Concomitant inhalation of cigarette smoke and aerosolized protein activates airway dendritic cells and induces allergic airway inflammation in a TLR-independent way. J Immunol 183(4):2758-66. [PubMed: 19635922]  [MGI Ref ID J:151472]

Rocchi R; Kimura H; Tzou SC; Suzuki K; Rose NR; Pinchera A; Ladenson PW; Caturegli P. 2007. Toll-like receptor-MyD88 and Fc receptor pathways of mast cells mediate the thyroid dysfunctions observed during nonthyroidal illness. Proc Natl Acad Sci U S A 104(14):6019-24. [PubMed: 17389381]  [MGI Ref ID J:120373]

Rodriguez N; Lang R; Wantia N; Cirl C; Ertl T; Durr S; Wagner H; Miethke T. 2008. Induction of iNOS by Chlamydophila pneumoniae requires MyD88-dependent activation of JNK. J Leukoc Biol 84(6):1585-93. [PubMed: 18799752]  [MGI Ref ID J:142747]

Rodriguez N; Wantia N; Fend F; Durr S; Wagner H; Miethke T. 2006. Differential involvement of TLR2 and TLR4 in host survival during pulmonary infection with Chlamydia pneumoniae. Eur J Immunol 36(5):1145-55. [PubMed: 16609927]  [MGI Ref ID J:114778]

Roffe E; Rothfuchs AG; Santiago HC; Marino AP; Ribeiro-Gomes FL; Eckhaus M; Antonelli LR; Murphy PM. 2012. IL-10 limits parasite burden and protects against fatal myocarditis in a mouse model of Trypanosoma cruzi infection. J Immunol 188(2):649-60. [PubMed: 22156594]  [MGI Ref ID J:180798]

Romero CD; Varma TK; Hobbs JB; Reyes A; Driver B; Sherwood ER. 2011. The toll-like receptor 4 agonist monophosphoryl lipid a augments innate host resistance to systemic bacterial infection. Infect Immun 79(9):3576-87. [PubMed: 21646453]  [MGI Ref ID J:175569]

Ropelle ER; Flores MB; Cintra DE; Rocha GZ; Pauli JR; Morari J; de Souza CT; Moraes JC; Prada PO; Guadagnini D; Marin RM; Oliveira AG; Augusto TM; Carvalho HF; Velloso LA; Saad MJ; Carvalheira JB. 2010. IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKbeta and ER stress inhibition. PLoS Biol 8(8):. [PubMed: 20808781]  [MGI Ref ID J:166779]

Rosenstein RK; Bezbradica JS; Yu S; Medzhitov R. 2014. Signaling pathways activated by a protease allergen in basophils. Proc Natl Acad Sci U S A 111(46):E4963-71. [PubMed: 25369937]  [MGI Ref ID J:216741]

Ruckdeschel K; Pfaffinger G; Haase R; Sing A; Weighardt H; Hacker G; Holzmann B; Heesemann J. 2004. Signaling of apoptosis through TLRs critically involves toll/IL-1 receptor domain-containing adapter inducing IFN-beta, but not MyD88, in bacteria-infected murine macrophages. J Immunol 173(5):3320-8. [PubMed: 15322195]  [MGI Ref ID J:92674]

Rudick CN; Jiang M; Yaggie RE; Pavlov VI; Done J; Heckman CJ; Whitfield C; Schaeffer AJ; Klumpp DJ. 2012. O-antigen modulates infection-induced pain states. PLoS One 7(8):e41273. [PubMed: 22899994]  [MGI Ref ID J:189938]

Rumbaut RE; Bellera RV; Randhawa JK; Shrimpton CN; Dasgupta SK; Dong JF; Burns AR. 2006. Endotoxin enhances microvascular thrombosis in mouse cremaster venules via a TLR4-dependent, neutrophil-independent mechanism. Am J Physiol Heart Circ Physiol 290(4):H1671-9. [PubMed: 16284241]  [MGI Ref ID J:108441]

Sanders CJ; Yu Y; Moore DA 3rd; Williams IR; Gewirtz AT. 2006. Humoral immune response to flagellin requires T cells and activation of innate immunity. J Immunol 177(5):2810-8. [PubMed: 16920916]  [MGI Ref ID J:139555]

Schaefer L; Babelova A; Kiss E; Hausser HJ; Baliova M; Krzyzankova M; Marsche G; Young MF; Mihalik D; Gotte M; Malle E; Schaefer RM; Grone HJ. 2005. The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages. J Clin Invest 115(8):2223-2233. [PubMed: 16025156]  [MGI Ref ID J:100228]

Schilling JD; Mulvey MA; Vincent CD; Lorenz RG; Hultgren SJ. 2001. Bacterial invasion augments epithelial cytokine responses to Escherichia coli through a lipopolysaccharide-dependent mechanism. J Immunol 166(2):1148-55. [PubMed: 11145696]  [MGI Ref ID J:66850]

Schurr JR; Young E; Byrne P; Steele C; Shellito JE; Kolls JK. 2005. Central role of toll-like receptor 4 signaling and host defense in experimental pneumonia caused by Gram-negative bacteria. Infect Immun 73(1):532-45. [PubMed: 15618193]  [MGI Ref ID J:94838]

Scott MJ; Billiar TR. 2008. Beta2-integrin-induced p38 MAPK activation is a key mediator in the CD14/TLR4/MD2-dependent uptake of lipopolysaccharide by hepatocytes. J Biol Chem 283(43):29433-46. [PubMed: 18701460]  [MGI Ref ID J:142561]

Segreti J; Gheusi G; Dantzer R; Kelley KW; Johnson RW. 1997. Defect in interleukin-1beta secretion prevents sickness behavior in C3H/HeJ mice. Physiol Behav 61(6):873-8. [PubMed: 9177560]  [MGI Ref ID J:41154]

Sen G; Khan AQ; Chen Q; Snapper CM. 2005. In vivo humoral immune responses to isolated pneumococcal polysaccharides are dependent on the presence of associated TLR ligands. J Immunol 175(5):3084-91. [PubMed: 16116197]  [MGI Ref ID J:113209]

Shalaby KH; Allard-Coutu A; O'Sullivan MJ; Nakada E; Qureshi ST; Day BJ; Martin JG. 2013. Inhaled birch pollen extract induces airway hyperresponsiveness via oxidative stress but independently of pollen-intrinsic NADPH oxidase activity, or the TLR4-TRIF pathway. J Immunol 191(2):922-33. [PubMed: 23776177]  [MGI Ref ID J:205448]

Shalaby KH; Jo T; Nakada E; Allard-Coutu A; Tsuchiya K; Hirota N; Qureshi ST; Maghni K; Rioux CR; Martin JG. 2012. ICOS-expressing CD4 T cells induced via TLR4 in the nasal mucosa are capable of inhibiting experimental allergic asthma. J Immunol 189(6):2793-804. [PubMed: 22908333]  [MGI Ref ID J:190232]

Shen XD; Ke B; Zhai Y; Gao F; Busuttil RW; Cheng G; Kupiec-Weglinski JW. 2005. Toll-like receptor and heme oxygenase-1 signaling in hepatic ischemia/reperfusion injury. Am J Transplant 5(8):1793-800. [PubMed: 15996225]  [MGI Ref ID J:114368]

Silver K; Ferry H; Crockford T; Cornall RJ. 2006. TLR4, TLR9 and MyD88 are not required for the positive selection of autoreactive B cells into the primary repertoire. Eur J Immunol 36(6):1404-12. [PubMed: 16703567]  [MGI Ref ID J:115059]

Silvia OJ; Urosevic N. 1999. Variations in LPS responsiveness among different mouse substrains of C3H lineage and their congenic derivative sublines. Immunogenetics 50(5-6):354-7. [PubMed: 10630301]  [MGI Ref ID J:169915]

Sing A; Roggenkamp A; Geiger AM; Heesemann J. 2002. Yersinia enterocolitica evasion of the host innate immune response by V antigen-induced IL-10 production of macrophages is abrogated in IL-10-deficient mice. J Immunol 168(3):1315-21. [PubMed: 11801671]  [MGI Ref ID J:127288]

Skidmore BJ; Chiller JM; Weigle WO; Riblet R; Watson J. 1976. Immunologic properties of bacterial lipopolysaccharide (LPS). III. Genetic linkage between the in vitro mitogenic and in vivo adjuvant properties of LPS. J Exp Med 143(1):143-50. [PubMed: 1244416]  [MGI Ref ID J:5593]

Sodhi CP; Shi XH; Richardson WM; Grant ZS; Shapiro RA; Prindle T Jr; Branca M; Russo A; Gribar SC; Ma C; Hackam DJ. 2010. Toll-like receptor-4 inhibits enterocyte proliferation via impaired beta-catenin signaling in necrotizing enterocolitis. Gastroenterology 138(1):185-96. [PubMed: 19786028]  [MGI Ref ID J:192520]

Sokol CL; Barton GM; Farr AG; Medzhitov R. 2008. A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol 9(3):310-8. [PubMed: 18300366]  [MGI Ref ID J:131552]

Sokol CL; Chu NQ; Yu S; Nish SA; Laufer TM; Medzhitov R. 2009. Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response. Nat Immunol 10(7):713-20. [PubMed: 19465907]  [MGI Ref ID J:150141]

Sorgi CA; Secatto A; Fontanari C; Turato WM; Belanger C; de Medeiros AI; Kashima S; Marleau S; Covas DT; Bozza PT; Faccioli LH. 2009. Histoplasma capsulatum cell wall {beta}-glucan induces lipid body formation through CD18, TLR2, and dectin-1 receptors: correlation with leukotriene B4 generation and role in HIV-1 infection. J Immunol 182(7):4025-35. [PubMed: 19299700]  [MGI Ref ID J:147134]

Spiller S; Dreher S; Meng G; Grabiec A; Thomas W; Hartung T; Pfeffer K; Hochrein H; Brade H; Bessler W; Wagner H; Kirschning CJ. 2007. Cellular recognition of trimyristoylated peptide or enterobacterial lipopolysaccharide via both TLR2 and TLR4. J Biol Chem 282(18):13190-8. [PubMed: 17353199]  [MGI Ref ID J:121930]

Spinner DS; Cho IS; Park SY; Kim JI; Meeker HC; Ye X; Lafauci G; Kerr DJ; Flory MJ; Kim BS; Kascsak RB; Wisniewski T; Levis WR; Schuller-Levis GB; Carp RI; Park E; Kascsak RJ. 2008. Accelerated prion disease pathogenesis in Toll-like receptor 4 signaling-mutant mice. J Virol 82(21):10701-8. [PubMed: 18715916]  [MGI Ref ID J:142968]

Standiford LR; Standiford TJ; Newstead MJ; Zeng X; Ballinger MN; Kovach MA; Reka AK; Bhan U. 2012. TLR4-dependent GM-CSF protects against lung injury in Gram-negative bacterial pneumonia. Am J Physiol Lung Cell Mol Physiol 302(5):L447-54. [PubMed: 22160309]  [MGI Ref ID J:183448]

Steiner AA; Chakravarty S; Rudaya AY; Herkenham M; Romanovsky AA. 2006. Bacterial lipopolysaccharide fever is initiated via Toll-like receptor 4 on hematopoietic cells. Blood 107(10):4000-2. [PubMed: 16403908]  [MGI Ref ID J:132740]

Stewart PW; Chapes SK. 2003. Role of major histocompatibility complex class II in resistance of mice to naturally acquired infection with Syphacia obvelata. Comp Med 53(1):70-4. [PubMed: 12625509]  [MGI Ref ID J:82325]

Suganami T; Mieda T; Itoh M; Shimoda Y; Kamei Y; Ogawa Y. 2007. Attenuation of obesity-induced adipose tissue inflammation in C3H/HeJ mice carrying a Toll-like receptor 4 mutation. Biochem Biophys Res Commun 354(1):45-9. [PubMed: 17210129]  [MGI Ref ID J:117843]

Suganami T; Yuan X; Shimoda Y; Uchio-Yamada K; Nakagawa N; Shirakawa I; Usami T; Tsukahara T; Nakayama K; Miyamoto Y; Yasuda K; Matsuda J; Kamei Y; Kitajima S; Ogawa Y. 2009. Activating transcription factor 3 constitutes a negative feedback mechanism that attenuates saturated Fatty acid/toll-like receptor 4 signaling and macrophage activation in obese adipose tissue. Circ Res 105(1):25-32. [PubMed: 19478204]  [MGI Ref ID J:164755]

Suhs KA; Marthaler BR; Welch RA; Hopkins WJ. 2011. Lack of association between the Tlr4 (Lpsd/Lpsd) genotype and increased susceptibility to Escherichia coli bladder infections in female C3H/HeJ mice. MBio 2(3):e00094-11. [PubMed: 21628500]  [MGI Ref ID J:182202]

Sun Y; Karmakar M; Roy S; Ramadan RT; Williams SR; Howell S; Shive CL; Han Y; Stopford CM; Rietsch A; Pearlman E. 2010. TLR4 and TLR5 on corneal macrophages regulate Pseudomonas aeruginosa keratitis by signaling through MyD88-dependent and -independent pathways. J Immunol 185(7):4272-83. [PubMed: 20826748]  [MGI Ref ID J:164286]

Suram S; Silveira LJ; Mahaffey S; Brown GD; Bonventre JV; Williams DL; Gow NA; Bratton DL; Murphy RC; Leslie CC. 2013. Cytosolic phospholipase A(2)alpha and eicosanoids regulate expression of genes in macrophages involved in host defense and inflammation. PLoS One 8(7):e69002. [PubMed: 23950842]  [MGI Ref ID J:204931]

Suzuki M; Nakano K. 1996. Increase in histamine synthesis by liver macrophages in CCl4-injured mast cell-deficient W/Wv mice. Biochem Pharmacol 52(5):809-13. [PubMed: 8765479]  [MGI Ref ID J:35601]

Tagliabue A; McCoy JL; Herberman RB. 1978. Refractoriness to migration inhibitory factor of macrophages of LPS nonresponder mouse strains. J Immunol 121(4):1223-6. [PubMed: 359704]  [MGI Ref ID J:6043]

Takakuwa T; Knopf HP; Sing A; Carsetti R; Galanos C; Freudenberg MA. 1996. Induction of CD14 expression in Lpsn, Lpsd and tumor necrosis factor receptor-deficient mice. Eur J Immunol 26(11):2686-92. [PubMed: 8921956]  [MGI Ref ID J:36452]

Tan AM; Chen HC; Pochard P; Eisenbarth SC; Herrick CA; Bottomly HK. 2010. TLR4 signaling in stromal cells is critical for the initiation of allergic Th2 responses to inhaled antigen. J Immunol 184(7):3535-44. [PubMed: 20194715]  [MGI Ref ID J:160085]

Tang SC; Arumugam TV; Xu X; Cheng A; Mughal MR; Jo DG; Lathia JD; Siler DA; Chigurupati S; Ouyang X; Magnus T; Camandola S; Mattson MP. 2007. Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits. Proc Natl Acad Sci U S A 104(34):13798-803. [PubMed: 17693552]  [MGI Ref ID J:124100]

Tang SC; Lathia JD; Selvaraj PK; Jo DG; Mughal MR; Cheng A; Siler DA; Markesbery WR; Arumugam TV; Mattson MP. 2008. Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid beta-peptide and the membrane lipid peroxidation product 4-hydroxynonenal. Exp Neurol 213(1):114-21. [PubMed: 18586243]  [MGI Ref ID J:138608]

Tanga FY; Nutile-McMenemy N; Deleo JA. 2005. The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy. Proc Natl Acad Sci U S A 102(16):5856-61. [PubMed: 15809417]  [MGI Ref ID J:97819]

Tavener SA; Long EM; Robbins SM; McRae KM; Van Remmen H; Kubes P. 2004. Immune cell Toll-like receptor 4 is required for cardiac myocyte impairment during endotoxemia. Circ Res 95(7):700-7. [PubMed: 15358664]  [MGI Ref ID J:101491]

Taylor KR; Yamasaki K; Radek KA; Di Nardo A; Goodarzi H; Golenbock D; Beutler B; Gallo RL. 2007. Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on Toll-like receptor 4, CD44, and MD-2. J Biol Chem 282(25):18265-75. [PubMed: 17400552]  [MGI Ref ID J:123387]

Thaete LG; Qu XW; Jilling T; Crawford SE; Fitchev P; Hirsch E; Khan S; Neerhof MG. 2013. Impact of toll-like receptor 4 deficiency on the response to uterine ischemia/reperfusion in mice. Reproduction 145(5):517-26. [PubMed: 23509372]  [MGI Ref ID J:197922]

Thomas JA; Tsen MF; White DJ; Horton JW. 2002. TLR4 inactivation and rBPI(21) block burn-induced myocardial contractile dysfunction. Am J Physiol Heart Circ Physiol 283(4):H1645-55. [PubMed: 12234819]  [MGI Ref ID J:108049]

Timmers L; Sluijter JP; van Keulen JK; Hoefer IE; Nederhoff MG; Goumans MJ; Doevendans PA; van Echteld CJ; Joles JA; Quax PH; Piek JJ; Pasterkamp G; de Kleijn DP. 2008. Toll-like receptor 4 mediates maladaptive left ventricular remodeling and impairs cardiac function after myocardial infarction. Circ Res 102(2):257-64. [PubMed: 18007026]  [MGI Ref ID J:145592]

Tjota MY; Williams JW; Lu T; Clay BS; Byrd T; Hrusch CL; Decker DC; de Araujo CA; Bryce PJ; Sperling AI. 2013. IL-33-dependent induction of allergic lung inflammation by FcgammaRIII signaling. J Clin Invest 123(5):2287-97. [PubMed: 23585480]  [MGI Ref ID J:201453]

Treml LS; Carlesso G; Hoek KL; Stadanlick JE; Kambayashi T; Bram RJ; Cancro MP; Khan WN. 2007. TLR stimulation modifies BLyS receptor expression in follicular and marginal zone B cells. J Immunol 178(12):7531-9. [PubMed: 17548587]  [MGI Ref ID J:148596]

Tsukumo DM; Carvalho-Filho MA; Carvalheira JB; Prada PO; Hirabara SM; Schenka AA; Araujo EP; Vassallo J; Curi R; Velloso LA; Saad MJ. 2007. Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes 56(8):1986-98. [PubMed: 17519423]  [MGI Ref ID J:126488]

Tsung A; Hoffman RA; Izuishi K; Critchlow ND; Nakao A; Chan MH; Lotze MT; Geller DA; Billiar TR. 2005. Hepatic ischemia/reperfusion injury involves functional TLR4 signaling in nonparenchymal cells. J Immunol 175(11):7661-8. [PubMed: 16301676]  [MGI Ref ID J:122164]

Tsung A; Klune JR; Zhang X; Jeyabalan G; Cao Z; Peng X; Stolz DB; Geller DA; Rosengart MR; Billiar TR. 2007. HMGB1 release induced by liver ischemia involves Toll-like receptor 4 dependent reactive oxygen species production and calcium-mediated signaling. J Exp Med 204(12):2913-23. [PubMed: 17984303]  [MGI Ref ID J:128522]

Tsung A; Sahai R; Tanaka H; Nakao A; Fink MP; Lotze MT; Yang H; Li J; Tracey KJ; Geller DA; Billiar TR. 2005. The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. J Exp Med 201(7):1135-43. [PubMed: 15795240]  [MGI Ref ID J:98036]

Tsung A; Zheng N; Jeyabalan G; Izuishi K; Klune JR; Geller DA; Lotze MT; Lu L; Billiar TR. 2007. Increasing numbers of hepatic dendritic cells promote HMGB1-mediated ischemia-reperfusion injury. J Leukoc Biol 81(1):119-28. [PubMed: 17062605]  [MGI Ref ID J:117230]

Vazquez-Torres A; Vallance BA; Bergman MA; Finlay BB; Cookson BT; Jones-Carson J; Fang FC. 2004. Toll-like receptor 4 dependence of innate and adaptive immunity to Salmonella: importance of the Kupffer cell network. J Immunol 172(10):6202-8. [PubMed: 15128808]  [MGI Ref ID J:89854]

Velazquez P; Wei B; McPherson M; Mendoza LM; Nguyen SL; Turovskaya O; Kronenberg M; Huang TT; Schrage M; Lobato LN; Fujiwara D; Brewer S; Arditi M; Cheng G; Sartor RB; Newberry RD; Braun J. 2008. Villous B cells of the small intestine are specialized for invariant NK T cell dependence. J Immunol 180(7):4629-38. [PubMed: 18354186]  [MGI Ref ID J:133099]

Vogel SN; Johnson D; Perera PY; Medvedev A; Lariviere L; Qureshi ST ; Malo D. 1999. Cutting edge: functional characterization of the effect of the C3H/HeJ defect in mice that lack an Lpsn gene: in vivo evidence for a dominant negative mutation. J Immunol 162(10):5666-70. [PubMed: 10229796]  [MGI Ref ID J:54987]

Vogl T; Tenbrock K; Ludwig S; Leukert N; Ehrhardt C; van Zoelen MA; Nacken W; Foell D; van der Poll T; Sorg C; Roth J. 2007. Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock. Nat Med 13(9):1042-9. [PubMed: 17767165]  [MGI Ref ID J:125179]

Wang MJ; Jeng KC; Shih PC. 2000. Differential expression and regulation of macrophage inflammatory protein (MIP)-1alpha and MIP-2 genes by alveolar and peritoneal macrophages in LPS-hyporesponsive C3H/HeJ mice Cell Immunol 204(2):88-95. [PubMed: 11069716]  [MGI Ref ID J:65822]

Wang S; Schmaderer C; Kiss E; Schmidt C; Bonrouhi M; Porubsky S; Gretz N; Schaefer L; Kirschning CJ; Popovic ZV; Grone HJ. 2010. Recipient Toll-like receptors contribute to chronic graft dysfunction by both MyD88- and TRIF-dependent signaling. Dis Model Mech 3(1-2):92-103. [PubMed: 20038715]  [MGI Ref ID J:157656]

Wang X; Moser C; Louboutin JP; Lysenko ES; Weiner DJ; Weiser JN; Wilson JM. 2002. Toll-like receptor 4 mediates innate immune responses to Haemophilus influenzae infection in mouse lung. J Immunol 168(2):810-5. [PubMed: 11777976]  [MGI Ref ID J:73739]

Wang XM; Kim HP; Nakahira K; Ryter SW; Choi AM. 2009. The heme oxygenase-1/carbon monoxide pathway suppresses TLR4 signaling by regulating the interaction of TLR4 with caveolin-1. J Immunol 182(6):3809-18. [PubMed: 19265160]  [MGI Ref ID J:145914]

Wang Y; Han G; Wang K; Liu G; Wang R; Xiao H; Li X; Hou C; Shen B; Guo R; Li Y; Chen G. 2014. Tumor-derived GM-CSF promotes inflammatory colon carcinogenesis via stimulating epithelial release of VEGF. Cancer Res 74(3):716-26. [PubMed: 24366884]  [MGI Ref ID J:208169]

Wang ZY; Yang D; Chen Q; Leifer CA; Segal DM; Su SB; Caspi RR; Howard ZO; Oppenheim JJ. 2006. Induction of dendritic cell maturation by pertussis toxin and its B subunit differentially initiate Toll-like receptor 4-dependent signal transduction pathways. Exp Hematol 34(8):1115-24. [PubMed: 16863919]  [MGI Ref ID J:111901]

Wantia N; Rodriguez N; Cirl C; Ertl T; Durr S; Layland LE; Wagner H; Miethke T. 2011. Toll-like receptors 2 and 4 regulate the frequency of IFNgamma-producing CD4+ T-cells during pulmonary infection with Chlamydia pneumoniae. PLoS One 6(11):e26101. [PubMed: 22096480]  [MGI Ref ID J:180980]

Warger T; Hilf N; Rechtsteiner G; Haselmayer P; Carrick DM; Jonuleit H; von Landenberg P; Rammensee HG; Nicchitta CV; Radsak MP; Schild H. 2006. Interaction of TLR2 and TLR4 ligands with the N-terminal domain of Gp96 amplifies innate and adaptive immune responses. J Biol Chem 281(32):22545-53. [PubMed: 16754684]  [MGI Ref ID J:116459]

Watson J; Largen M; McAdam KP. 1978. Genetic control of endotoxic responses in mice. J Exp Med 147(1):39-49. [PubMed: 342667]  [MGI Ref ID J:5938]

Weighardt H; Kaiser-Moore S; Vabulas RM; Kirschning CJ; Wagner H; Holzmann B. 2002. Cutting edge: myeloid differentiation factor 88 deficiency improves resistance against sepsis caused by polymicrobial infection. J Immunol 169(6):2823-7. [PubMed: 12218091]  [MGI Ref ID J:120435]

Whitaker SM; Colmenares M; Pestana KG; McMahon-Pratt D. 2008. Leishmania pifanoi proteoglycolipid complex P8 induces macrophage cytokine production through Toll-like receptor 4. Infect Immun 76(5):2149-56. [PubMed: 18299340]  [MGI Ref ID J:134478]

Wong PM; Kang A; Chen H; Yuan Q; Fan P; Sultzer BM; Kan YW; Chung SW. 1999. Lps(d)/Ran of endotoxin-resistant C3H/HeJ mice is defective in mediating lipopolysaccharide endotoxin responses. Proc Natl Acad Sci U S A 96(20):11543-8. [PubMed: 10500213]  [MGI Ref ID J:57938]

Woods JP; Frelinger JA; Warrack G; Cannon JG. 1988. Mouse genetic locus Lps influences susceptibility to Neisseria meningitidis infection. Infect Immun 56(8):1950-5. [PubMed: 3397181]  [MGI Ref ID J:27288]

Wright SD; Burton C; Hernandez M; Hassing H; Montenegro J; Mundt S; Patel S; Card DJ; Hermanowski-Vosatka A; Bergstrom JD; Sparrow CP; Detmers PA; Chao YS. 2000. Infectious agents are not necessary for murine atherogenesis. J Exp Med 191(8):1437-42. [PubMed: 10770809]  [MGI Ref ID J:61722]

Wu SC; Yang JC; Rau CS; Chen YC; Lu TH; Lin MW; Tzeng SL; Wu YC; Wu CJ; Hsieh CH. 2013. Profiling circulating microRNA expression in experimental sepsis using cecal ligation and puncture. PLoS One 8(10):e77936. [PubMed: 24205035]  [MGI Ref ID J:209241]

Xiang M; Yin L; Li Y; Xiao G; Vodovotz Y; Billiar TR; Wilson MA; Fan J. 2011. Hemorrhagic shock activates lung endothelial reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase via neutrophil NADPH oxidase. Am J Respir Cell Mol Biol 44(3):333-40. [PubMed: 20418360]  [MGI Ref ID J:183358]

Yang HZ; Wang JP; Mi S; Liu HZ; Cui B; Yan HM; Yan J; Li Z; Liu H; Hua F; Lu W; Hu ZW. 2012. TLR4 activity is required in the resolution of pulmonary inflammation and fibrosis after acute and chronic lung injury. Am J Pathol 180(1):275-92. [PubMed: 22062220]  [MGI Ref ID J:180182]

Yang R; Murillo FM; Delannoy MJ; Blosser RL; Yutzy WH 4th; Uematsu S; Takeda K; Akira S; Viscidi RP; Roden RB. 2005. B lymphocyte activation by human papillomavirus-like particles directly induces Ig class switch recombination via TLR4-MyD88. J Immunol 174(12):7912-9. [PubMed: 15944297]  [MGI Ref ID J:100870]

Yang X; Murthy V; Schultz K; Tatro JB; Fitzgerald KA; Beasley D. 2006. Toll-like receptor 3 signaling evokes a proinflammatory and proliferative phenotype in human vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 291(5):H2334-43. [PubMed: 16782847]  [MGI Ref ID J:116310]

Yano J; Palmer GE; Eberle KE; Peters BM; Vogl T; McKenzie AN; Fidel PL Jr. 2014. Vaginal epithelial cell-derived S100 alarmins induced by Candida albicans via pattern recognition receptor interactions are sufficient but not necessary for the acute neutrophil response during experimental vaginal candidiasis. Infect Immun 82(2):783-92. [PubMed: 24478092]  [MGI Ref ID J:209808]

Yao C; Purwanti N; Karabasil MR; Azlina A; Javkhlan P; Hasegawa T; Akamatsu T; Hosoi T; Ozawa K; Hosoi K. 2010. Potential down-regulation of salivary gland AQP5 by LPS via cross-coupling of NF-kappaB and p-c-Jun/c-Fos. Am J Pathol 177(2):724-34. [PubMed: 20522648]  [MGI Ref ID J:163414]

Yohe HC; O'Hara KA; Hunt JA; Kitzmiller TJ; Wood SG; Bement JL; Bement WJ; Szakacs JG; Wrighton SA; Jacobs JM; Kostrubsky V; Sinclair PR; Sinclair JF. 2006. Involvement of Toll-like receptor 4 in acetaminophen hepatotoxicity. Am J Physiol Gastrointest Liver Physiol 290(6):G1269-79. [PubMed: 16439473]  [MGI Ref ID J:111091]

Yoshida S; Goto Y; Miyamoto H; Fujio H; Mizuguchi Y. 1991. Association of Lps gene with natural resistance of mouse macrophages against Legionella pneumophila. FEMS Microbiol Immunol 4(1):51-6. [PubMed: 1815711]  [MGI Ref ID J:657]

Yu FS; Cornicelli MD; Kovach MA; Newstead MW; Zeng X; Kumar A; Gao N; Yoon SG; Gallo RL; Standiford TJ. 2010. Flagellin stimulates protective lung mucosal immunity: role of cathelicidin-related antimicrobial peptide. J Immunol 185(2):1142-9. [PubMed: 20566829]  [MGI Ref ID J:162021]

Yu H; Ha T; Liu L; Wang X; Gao M; Kelley J; Kao R; Williams D; Li C. 2012. Scavenger receptor A (SR-A) is required for LPS-induced TLR4 mediated NF-kappaB activation in macrophages. Biochim Biophys Acta 1823(7):1192-8. [PubMed: 22627090]  [MGI Ref ID J:185204]

Yusuf N; Nasti TH; Long JA; Naseemuddin M; Lucas AP; Xu H; Elmets CA. 2008. Protective role of Toll-like receptor 4 during the initiation stage of cutaneous chemical carcinogenesis. Cancer Res 68(2):615-22. [PubMed: 18199559]  [MGI Ref ID J:131415]

Yvan-Charvet L; Welch C; Pagler TA; Ranalletta M; Lamkanfi M; Han S; Ishibashi M; Li R; Wang N; Tall AR. 2008. Increased inflammatory gene expression in ABC transporter-deficient macrophages: free cholesterol accumulation, increased signaling via toll-like receptors, and neutrophil infiltration of atherosclerotic lesions. Circulation 118(18):1837-47. [PubMed: 18852364]  [MGI Ref ID J:165622]

Zamboni DS; Campos MA; Torrecilhas AC; Kiss K; Samuel JE; Golenbock DT; Lauw FN; Roy CR; Almeida IC; Gazzinelli RT. 2004. Stimulation of toll-like receptor 2 by Coxiella burnetii is required for macrophage production of pro-inflammatory cytokines and resistance to infection. J Biol Chem 279(52):54405-15. [PubMed: 15485838]  [MGI Ref ID J:95155]

Zampell JC; Elhadad S; Avraham T; Weitman E; Aschen S; Yan A; Mehrara BJ. 2012. Toll-like receptor deficiency worsens inflammation and lymphedema after lymphatic injury. Am J Physiol Cell Physiol 302(4):C709-19. [PubMed: 22049214]  [MGI Ref ID J:180614]

Zanotti G; Casiraghi M; Abano JB; Tatreau JR; Sevala M; Berlin H; Smyth S; Funkhouser WK; Burridge K; Randell SH; Egan TM. 2009. Novel critical role of Toll-like receptor 4 in lung ischemia-reperfusion injury and edema. Am J Physiol Lung Cell Mol Physiol 297(1):L52-63. [PubMed: 19376887]  [MGI Ref ID J:151006]

Zhang B; Choi JJ; Eum SY; Daunert S; Toborek M. 2013. TLR4 signaling is involved in brain vascular toxicity of PCB153 bound to nanoparticles. PLoS One 8(5):e63159. [PubMed: 23690990]  [MGI Ref ID J:202173]

Zhang X; Shan P; Jiang G; Cohn L; Lee PJ. 2006. Toll-like receptor 4 deficiency causes pulmonary emphysema. J Clin Invest 116(11):3050-9. [PubMed: 17053835]  [MGI Ref ID J:114985]

Zhang Y; Woodruff M; Zhang Y; Miao J; Hanley G; Stuart C; Zeng X; Prabhakar S; Moorman J; Zhao B; Yin D. 2008. Toll-like receptor 4 mediates chronic restraint stress-induced immune suppression. J Neuroimmunol 194(1-2):115-22. [PubMed: 18192029]  [MGI Ref ID J:131903]

Zhou Q; Desta T; Fenton M; Graves DT; Amar S. 2005. Cytokine profiling of macrophages exposed to Porphyromonas gingivalis, its lipopolysaccharide, or its FimA protein. Infect Immun 73(2):935-43. [PubMed: 15664935]  [MGI Ref ID J:95773]

Zou L; Feng Y; Li Y; Zhang M; Chen C; Cai J; Gong Y; Wang L; Thurman JM; Wu X; Atkinson JP; Chao W. 2013. Complement factor B is the downstream effector of TLRs and plays an important role in a mouse model of severe sepsis. J Immunol 191(11):5625-35. [PubMed: 24154627]  [MGI Ref ID J:207017]

de Groot D; Hoefer IE; Grundmann S; Schoneveld A; Haverslag RT; van Keulen JK; Bot PT; Timmers L; Piek JJ; Pasterkamp G; de Kleijn DP. 2011. Arteriogenesis requires toll-like receptor 2 and 4 expression in bone-marrow derived cells. J Mol Cell Cardiol 50(1):25-32. [PubMed: 20708624]  [MGI Ref ID J:171028]

van Rossum AM; Lysenko ES; Weiser JN. 2005. Host and bacterial factors contributing to the clearance of colonization by Streptococcus pneumoniae in a murine model. Infect Immun 73(11):7718-26. [PubMed: 16239576]  [MGI Ref ID J:104292]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           RB21

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, homozygous mice may be bred together. Of note, the onset and severity of both the spontaneous and experimentally-induced inflammatory phenotype of Il10-deficient mice is strongly influenced by the genetic background and the husbandry conditions (specific health status/commensal flora) of the vivaria in which mice are maintained. As such, high SPF conditions may attenuate the desired Il10-deficient phenotype.
Breeding Considerations This strain is a challenging breeder.
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Weeks of AgePrice per mouse (US dollars $)GenderGenotypes Provided
4 weeks $354.30Female or MaleHomozygous for Il10tm1Cgn  
5 weeks $354.30Female or MaleHomozygous for Il10tm1Cgn  
6 weeks $357.75Female or MaleHomozygous for Il10tm1Cgn  
7 weeks $361.20Female or MaleHomozygous for Il10tm1Cgn  
8 weeks $364.65Female or MaleHomozygous for Il10tm1Cgn  

Standard Supply

Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.

Supply Notes

  • Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Weeks of AgePrice per mouse (US dollars $)GenderGenotypes Provided
4 weeks $460.60Female or MaleHomozygous for Il10tm1Cgn  
5 weeks $460.60Female or MaleHomozygous for Il10tm1Cgn  
6 weeks $465.10Female or MaleHomozygous for Il10tm1Cgn  
7 weeks $469.60Female or MaleHomozygous for Il10tm1Cgn  
8 weeks $474.10Female or MaleHomozygous for Il10tm1Cgn  

Standard Supply

Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.

Supply Notes

  • Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.

Control Information

   005973 C3Bir.129P2(B6)-Il10C3Bir/LtJ This strain is in cryopreservation. For most research applications the approximate control, C3H/HeJ (#000659), will be acceptable, please contact our technical support if you require assistance.
   000659 C3H/HeJ (approximate)
   005972 C3H/HeJBirLtJ (approximate) This strain is in cryopreservation. For most research applications the approximate control, C3H/HeJ (#000659), will be acceptable, please contact our technical support if you require assistance.
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.

Important Note

This strain is homozygous for Pde6brd1 and Tlr4Lps-d.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use

General Terms and Conditions

For Licensing and Use Restrictions view the link(s) below:
- Health Status Advisory
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries regarding Terms of Use

Contracts Administration


JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty


In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.