| 
| ||||||||||||||||||
- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
- Health & care
- References
- Pricing & purchasing
- Terms of use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Former Names 129.Cg-Foxg1tm1(cre)Skm/J (Changed: 29-AUG-08 ) STOCK Foxg1tm1(cre)Skm (Changed: 15-DEC-04 ) STOCK-Foxg1tm1(Cre)Skm (Changed: 15-DEC-04 ) Type Congenic; Mutant Strain; Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Generation N9+1F2N0+N1p (09-NOV-05)
Generation DefinitionsDonating Investigator Susan K. McConnell, Stanford University Description
This strain expresses Cre recombinase from the endogenous Foxg1 locus. Forkhead box G1 is required for telencephalon development and is expressed specifically in the telencephalon and discrete head structures. When crossed with a strain containing loxP site flanked sequence of interest, Cre-mediated recombination results in tissue-specific deletion of the target. Recombination occurs in the telencephalon, anterior optic vesicle (developing lens and retina), otic vesicle, facial and head ectoderm, olfactory epithelium, mid-hindbrain junction and pharyngeal pouches. Mice that are homozygous for the targeted mutation die perinatally. Heterozygous mutant mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. This mutant mouse strain represents a model that may be useful in studies of telencephalic development.Development
A targeting vector containing cre coding sequence, neomycin resistance and herpes simplex virus thymidine kinase genes was used to disrupt most of the coding sequence the targeted gene. The endogenous Foxg1 promoter drives expression of the Cre recombinase through the in-frame insertion of the cre coding sequence to the first 13 codons of the Foxg1 gene. The construct was electroporated into 129P2/OlaHsd-Hprtb-m1 derived HM-1 embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6 blastocysts. The resulting chimeric animals were initially backcrossed to Swiss Webster mice, then backcrossed for 9 generations on a 129 background.
Control Information
| Control | ||
|---|---|---|
| Wild-type from the colony | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Foxg1tm1(cre)Skm allele
006084 B6.129P2(Cg)-Foxg1tm1(cre)Skm/J View Strains carrying Foxg1tm1(cre)Skm (1 strain)
Additional Web Information
Introduction to Cre-lox technology
Phenotype
Phenotype Information
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested. Rett Syndrome, Congenital Variant (FOXG1)
assigned by genotype
Foxg1tm1(cre)Skm/Foxg1+
129(Cg)-Foxg1tm1(cre)Skm/J
- normal phenotype
- no abnormal phenotype detected
- heterozygous mutant mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities (MGI Ref ID J:62916)
Foxg1tm1(cre)Skm/Foxg1tm1(cre)Skm
129(Cg)-Foxg1tm1(cre)Skm/J
- mortality/aging
- complete perinatal lethality
- homozygous mice die perinatally (MGI Ref ID J:62916)
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Foxg1tm1(cre)Skm/Foxg1+
B6.129P2-Foxg1tm1(cre)Skm
- nervous system phenotype
- abnormal brain morphology
- length of the medio-lateral and midline anterior-posterior axes of the cerebral hemispheres is reduced (MGI Ref ID J:128207)
- reduction in dimensions of cerebral hemispheres is observed by postnatal day 4 (MGI Ref ID J:128207)
- area of cortical sheet is reduced at postnatal day 8 and in adult brain (MGI Ref ID J:128207)
- abnormal forebrain morphology
- volume of prosencephalon is reduced by 23% (MGI Ref ID J:128207)
- abnormal telencephalon morphology (MGI Ref ID J:128207)
- abnormal cerebral cortex morphology
- volume of cerebral cortex is reduced by 40.7% (MGI Ref ID J:128207)
- radial domain of cerebral cortex is substantially disrupted, especially in supragranular layers (MGI Ref ID J:128207)
- thickness of supragranular layer is reduced by 41.4% although granular and infragranular layers are not reduced (MGI Ref ID J:128207)
- abnormal hippocampus size
- volume of hippocampus is reduced by 18.6% (MGI Ref ID J:128207)
- abnormal striatum morphology
- volume of striatum is reduced by 29.7% (MGI Ref ID J:128207)
- abnormal thalamus morphology
- forebrain hypoplasia (MGI Ref ID J:128207)
Foxg1tm1(cre)Skm/Foxg1+
involves: C57BL/6 * CBA
- nervous system phenotype
- abnormal brain morphology
- reduction in dimensions of cerebral hemispheres is observed by postnatal day 4, however, on the mixed background the substantial reductions reported in the C57BL/6J forebrain are not observed (MGI Ref ID J:128207)
This mouse can be used to support research in many areas including:
cre relatedNeurobiology Research
Cre-lox System
Cre Recombinase expression in neural tissue
Research Tools
Cre-lox System
Cre Recombinase Expression
Developmental Biology Research
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Tissue/Cell Markers
Tissue/Cell Markers: Cre-lox System
Tissue/Cell Markers: astrocytes, neurons
Neurobiology Research
Foxg1tm1(cre)Skm relatedResearch Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Developmental Biology Research
Cell Motility Defects
Craniofacial and Palate Defects
Defects in Cell Adhesion Molecules
Defects in Extracellular Matrix Molecules
Neural Crest Defects
Neural Tube Defects
Neurodevelopmental Defects
Neurobiology Research
Astrocyte Defects
Cortical Defects
Hearing Defects
Neural Tube Defects
Neurodevelopmental Defects
Neurotrophic Factor Defects
Sensorineural Research
Eye Defects
Hearing Defects
Olfactory Defects
Retinal Degeneration
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Foxg1tm1(cre)Skm | ||
|---|---|---|---|
| Allele Name | targeted mutation 1, Susan K McConnell | ||
| Allele Type | Targeted (knock-in) | ||
| Common Name(s) | BF1-cre; FoxG1Cre; Foxg1-; Foxg1-Cre; Foxg1:Cre; Foxg1Cre; Foxg1KiCre; TgH(Foxg1-Cre)1Skm; | ||
| Mutation Made By | Susan McConnell, Stanford University | ||
| Strain of Origin | 129P2/OlaHsd-Hprt | ||
| ES Cell Line Name | HM-1 | ||
| ES Cell Line Strain | 129P2/OlaHsd-Hprt | ||
| Site of Expression | telencephalon, anterior optic vesicle (developing lens and retina), otic vesicle, facial and head ectoderm, olfactory epithelium, mid-hindbrain junction and pharyngeal pouches | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Driver Note | Foxg1 | ||
| General Note | Cre mediated recombination was demonstrated in 3 reporter mouse lines in the following tissues: telencephalon, anterior optic vesicle, otic vesicle, facial and head ectoderm, olfactory epithelium, mid-hindbrain junction, and pharyngeal pouches. | ||
| Molecular Note | Most of the coding region was replaced with a cre gene and a neomycin cassette. The cre gene sequence was fused in-frame following the first 13 codons of the gene. The endogenous promoter is active in telencephalon, anterior optic vesicle, otic vesicle, facial and head ectoderm, olfactory epithelium, mid-hindbrain junction and pharyngeal pouches. [MGI Ref ID J:62916] | ||
| Gene Symbol and Name | Foxg1, forkhead box G1 | ||
| Chromosome | 12 | ||
| Gene Common Name(s) | 2900064B05Rik; BF-1; BF1; BF1A; BF2; FHKL3; FKH2; FKHL1; FKHL2; FKHL3; FKHL4; FOXG1A; FOXG1B; FOXG1C; HBF-1; HBF-2; HBF-3; HBF-G2; HBF2; HFK1; HFK2; HFK3; HNF-3/forkhead homolog, brain factor 1; Hfh9; Hfhbf1; KHL2; QIN; RATBF1A; RIKEN cDNA 2900064B05 gene; | ||
Genotyping
Genotyping Information
Genotyping Protocols
Foxg1tm1(cre)Skmalternate2, Separated PCR
Foxg1tm1(cre)Skm, Separated PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Hebert JM; McConnell SK. 2000. Targeting of cre to the Foxg1 (BF-1) locus mediates loxP recombination in the telencephalon and other developing head structures. Dev Biol 222(2):296-306. [PubMed: 10837119] [MGI Ref ID J:62916]
Additional References
Ferguson KL; Vanderluit JL; Hebert JM; McIntosh WC; Tibbo E; MacLaurin JG; Park DS; Wallace VA; Vooijs M; McConnell SK; Slack RS. 2002. Telencephalon-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal cortical development. EMBO J 21(13):3337-46. [PubMed: 12093735] [MGI Ref ID J:77762]
Hebert JM; Hayhurst M; Marks ME; Kulessa H; Hogan BL; McConnell SK. 2003. BMP ligands act redundantly to pattern the dorsal telencephalic midline. Genesis 35(4):214-9. [PubMed: 12717732] [MGI Ref ID J:83123]
Hebert JM; Mishina Y; McConnell SK. 2002. BMP signaling is required locally to pattern the dorsal telencephalic midline. Neuron 35(6):1029-41. [PubMed: 12354394] [MGI Ref ID J:79021]
Ma L; Harada T; Harada C; Romero M; Hebert JM; McConnell SK; Parada LF. 2002. Neurotrophin-3 is required for appropriate establishment of thalamocortical connections. Neuron 36(4):623-34. [PubMed: 12441052] [MGI Ref ID J:81563]
Foxg1tm1(cre)Skm relatedAchim K; Peltopuro P; Lahti L; Li J; Salminen M; Partanen J. 2012. Distinct developmental origins and regulatory mechanisms for GABAergic neurons associated with dopaminergic nuclei in the ventral mesodiencephalic region. Development 139(13):2360-70. [PubMed: 22627282] [MGI Ref ID J:185533]
Ahrens MJ; Li Y; Jiang H; Dudley AT. 2009. Convergent extension movements in growth plate chondrocytes require gpi-anchored cell surface proteins. Development 136(20):3463-74. [PubMed: 19762422] [MGI Ref ID J:153618]
Andrusiak MG; McClellan KA; Dugal-Tessier D; Julian LM; Rodrigues SP; Park DS; Kennedy TE; Slack RS. 2011. Rb/E2F regulates expression of neogenin during neuronal migration. Mol Cell Biol 31(2):238-47. [PubMed: 21059867] [MGI Ref ID J:170280]
Anthony TE; Mason HA; Gridley T; Fishell G; Heintz N. 2005. Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells. Genes Dev 19(9):1028-33. [PubMed: 15879553] [MGI Ref ID J:98262]
Arbour N; Vanderluit JL; Le Grand JN; Jahani-Asl A; Ruzhynsky VA; Cheung EC; Kelly MA; MacKenzie AE; Park DS; Opferman JT; Slack RS. 2008. Mcl-1 is a key regulator of apoptosis during CNS development and after DNA damage. J Neurosci 28(24):6068-78. [PubMed: 18550749] [MGI Ref ID J:137346]
Arnold JS; Braunstein EM; Ohyama T; Groves AK; Adams JC; Brown MC; Morrow BE. 2006. Tissue-specific roles of Tbx1 in the development of the outer, middle and inner ear, defective in 22q11DS patients. Hum Mol Genet 15(10):1629-39. [PubMed: 16600992] [MGI Ref ID J:109536]
Arnold JS; Werling U; Braunstein EM; Liao J; Nowotschin S; Edelmann W; Hebert JM; Morrow BE. 2006. Inactivation of Tbx1 in the pharyngeal endoderm results in 22q11DS malformations. Development 133(5):977-87. [PubMed: 16452092] [MGI Ref ID J:105980]
Barrionuevo F; Naumann A; Bagheri-Fam S; Speth V; Taketo MM; Scherer G; Neubuser A. 2008. Sox9 is required for invagination of the otic placode in mice. Dev Biol 317(1):213-24. [PubMed: 18377888] [MGI Ref ID J:136177]
Berube NG; Mangelsdorf M; Jagla M; Vanderluit J; Garrick D; Gibbons RJ; Higgs DR; Slack RS; Picketts DJ. 2005. The chromatin-remodeling protein ATRX is critical for neuronal survival during corticogenesis. J Clin Invest 115(2):258-67. [PubMed: 15668733] [MGI Ref ID J:95953]
Bobola N; Carapuco M; Ohnemus S; Kanzler B; Leibbrandt A; Neubuser A; Drouin J; Mallo M. 2003. Mesenchymal patterning by Hoxa2 requires blocking Fgf-dependent activation of Ptx1. Development 130(15):3403-14. [PubMed: 12810588] [MGI Ref ID J:83660]
Brooker R; Hozumi K; Lewis J. 2006. Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear. Development 133(7):1277-86. [PubMed: 16495313] [MGI Ref ID J:107414]
Brown AS; Epstein DJ. 2011. Otic ablation of smoothened reveals direct and indirect requirements for Hedgehog signaling in inner ear development. Development 138(18):3967-76. [PubMed: 21831920] [MGI Ref ID J:180898]
Brzezinski JA 4th; Lamba DA; Reh TA. 2010. Blimp1 controls photoreceptor versus bipolar cell fate choice during retinal development. Development 137(4):619-29. [PubMed: 20110327] [MGI Ref ID J:156665]
Causeret F; Ensini M; Teissier A; Kessaris N; Richardson WD; Lucas de Couville T; Pierani A. 2011. Dbx1-expressing cells are necessary for the survival of the Mammalian anterior neural and craniofacial structures. PLoS One 6(4):e19367. [PubMed: 21552538] [MGI Ref ID J:172360]
Chacon-Heszele MF; Ren D; Reynolds AB; Chi F; Chen P. 2012. Regulation of cochlear convergent extension by the vertebrate planar cell polarity pathway is dependent on p120-catenin. Development 139(5):968-78. [PubMed: 22318628] [MGI Ref ID J:182748]
Chang W; Lin Z; Kulessa H; Hebert J; Hogan BL; Wu DK. 2008. Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movements. PLoS Genet 4(4):e1000050. [PubMed: 18404215] [MGI Ref ID J:136636]
Chen L; Liao G; Waclaw RR; Burns KA; Linquist D; Campbell K; Zheng Y; Kuan CY. 2007. Rac1 controls the formation of midline commissures and the competency of tangential migration in ventral telencephalic neurons. J Neurosci 27(14):3884-93. [PubMed: 17409253] [MGI Ref ID J:121201]
Chen L; Liao G; Yang L; Campbell K; Nakafuku M; Kuan CY; Zheng Y. 2006. Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly. Proc Natl Acad Sci U S A 103(44):16520-5. [PubMed: 17050694] [MGI Ref ID J:116100]
Chen L; Melendez J; Campbell K; Kuan CY; Zheng Y. 2009. Rac1 deficiency in the forebrain results in neural progenitor reduction and microcephaly. Dev Biol 325(1):162-70. [PubMed: 19007770] [MGI Ref ID J:143541]
Cheung EC; Joza N; Steenaart NA; McClellan KA; Neuspiel M; McNamara S; MacLaurin JG; Rippstein P; Park DS; Shore GC; McBride HM; Penninger JM; Slack RS. 2006. Dissociating the dual roles of apoptosis-inducing factor in maintaining mitochondrial structure and apoptosis. EMBO J 25(17):4061-73. [PubMed: 16917506] [MGI Ref ID J:112874]
Dastidar SG; Bardai FH; Ma C; Price V; Rawat V; Verma P; Narayanan V; D'Mello SR. 2012. Isoform-specific toxicity of Mecp2 in postmitotic neurons: suppression of neurotoxicity by FoxG1. J Neurosci 32(8):2846-55. [PubMed: 22357867] [MGI Ref ID J:182500]
Deng M; Pan L; Xie X; Gan L. 2010. Requirement for Lmo4 in the vestibular morphogenesis of mouse inner ear. Dev Biol 338(1):38-49. [PubMed: 19913004] [MGI Ref ID J:156733]
Dominguez-Frutos E; Lopez-Hernandez I; Vendrell V; Neves J; Gallozzi M; Gutsche K; Quintana L; Sharpe J; Knoepfler PS; Eisenman RN; Trumpp A; Giraldez F; Schimmang T. 2011. N-myc controls proliferation, morphogenesis, and patterning of the inner ear. J Neurosci 31(19):7178-89. [PubMed: 21562282] [MGI Ref ID J:173398]
Duggan CD; Demaria S; Baudhuin A; Stafford D; Ngai J. 2008. Foxg1 is required for development of the vertebrate olfactory system. J Neurosci 28(20):5229-39. [PubMed: 18480279] [MGI Ref ID J:136319]
Eagleson KL; Schlueter McFadyen-Ketchum LJ; Ahrens ET; Mills PH; Does MD; Nickols J; Levitt P. 2007. Disruption of Foxg1 expression by knock-in of cre recombinase: effects on the development of the mouse telencephalon. Neuroscience 148(2):385-99. [PubMed: 17640820] [MGI Ref ID J:128207]
Feng J; Xu Y; Wang M; Ruan Y; So KF; Tissir F; Goffinet A; Zhou L. 2012. A role for atypical cadherin Celsr3 in hippocampal maturation and connectivity. J Neurosci 32(40):13729-43. [PubMed: 23035085] [MGI Ref ID J:190932]
Ferguson KL; Vanderluit JL; Hebert JM; McIntosh WC; Tibbo E; MacLaurin JG; Park DS; Wallace VA; Vooijs M; McConnell SK; Slack RS. 2002. Telencephalon-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal cortical development. EMBO J 21(13):3337-46. [PubMed: 12093735] [MGI Ref ID J:77762]
Fernandes M; Gutin G; Alcorn H; McConnell SK; Hebert JM. 2007. Mutations in the BMP pathway in mice support the existence of two molecular classes of holoprosencephaly. Development 134(21):3789-94. [PubMed: 17913790] [MGI Ref ID J:126436]
Ferrer-Vaquer A; Maurey P; Firnberg N; Leibbrandt A; Neubuser A. 2007. Expression of ASK1 during chick and early mouse development. Gene Expr Patterns 7(7):808-16. [PubMed: 17602894] [MGI Ref ID J:123567]
Ferretti E; Li B; Zewdu R; Wells V; Hebert JM; Karner C; Anderson MJ; Williams T; Dixon J; Dixon MJ; Depew MJ; Selleri L. 2011. A conserved Pbx-Wnt-p63-Irf6 regulatory module controls face morphogenesis by promoting epithelial apoptosis. Dev Cell 21(4):627-41. [PubMed: 21982646] [MGI Ref ID J:178316]
Ferri A; Favaro R; Beccari L; Bertolini J; Mercurio S; Nieto-Lopez F; Verzeroli C; La Regina F; De Pietri Tonelli D; Ottolenghi S; Bovolenta P; Nicolis SK. 2013. Sox2 is required for embryonic development of the ventral telencephalon through the activation of the ventral determinants Nkx2.1 and Shh. Development 140(6):1250-61. [PubMed: 23444355] [MGI Ref ID J:194843]
Flames N; Long JE; Garratt AN; Fischer TM; Gassmann M; Birchmeier C; Lai C; Rubenstein JL; Marin O. 2004. Short- and long-range attraction of cortical GABAergic interneurons by neuregulin-1. Neuron 44(2):251-61. [PubMed: 15473965] [MGI Ref ID J:130617]
Freyer L; Morrow BE. 2010. Canonical Wnt signaling modulates Tbx1, Eya1, and Six1 expression, restricting neurogenesis in the otic vesicle. Dev Dyn 239(6):1708-22. [PubMed: 20503367] [MGI Ref ID J:160589]
Fuccillo M; Rallu M; McMahon AP; Fishell G. 2004. Temporal requirement for hedgehog signaling in ventral telencephalic patterning. Development 131(20):5031-40. [PubMed: 15371303] [MGI Ref ID J:93609]
Furusho M; Kaga Y; Ishii A; Hebert JM; Bansal R. 2011. Fibroblast growth factor signaling is required for the generation of oligodendrocyte progenitors from the embryonic forebrain. J Neurosci 31(13):5055-66. [PubMed: 21451043] [MGI Ref ID J:171201]
Geng X; Speirs C; Lagutin O; Inbal A; Liu W; Solnica-Krezel L; Jeong Y; Epstein DJ; Oliver G. 2008. Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly. Dev Cell 15(2):236-47. [PubMed: 18694563] [MGI Ref ID J:140315]
Ghanem N; Andrusiak MG; Svoboda D; Al Lafi SM; Julian LM; McClellan KA; De Repentigny Y; Kothary R; Ekker M; Blais A; Park DS; Slack RS. 2012. The Rb/E2F Pathway Modulates Neurogenesis through Direct Regulation of the Dlx1/Dlx2 Bigene Cluster. J Neurosci 32(24):8219-30. [PubMed: 22699903] [MGI Ref ID J:185576]
Grimsley-Myers CM; Sipe CW; Geleoc GS; Lu X. 2009. The small GTPase Rac1 regulates auditory hair cell morphogenesis. J Neurosci 29(50):15859-69. [PubMed: 20016102] [MGI Ref ID J:157099]
Grimsley-Myers CM; Sipe CW; Wu DK; Lu X. 2012. Redundant functions of Rac GTPases in inner ear morphogenesis. Dev Biol 362(2):172-86. [PubMed: 22182523] [MGI Ref ID J:180774]
Gutin G; Fernandes M; Palazzolo L; Paek H; Yu K; Ornitz DM; McConnell SK; Hebert JM. 2006. FGF signalling generates ventral telencephalic cells independently of SHH. Development 133(15):2937-46. [PubMed: 16818446] [MGI Ref ID J:119019]
Hanashima C; Fernandes M; Hebert JM; Fishell G. 2007. The role of Foxg1 and dorsal midline signaling in the generation of Cajal-Retzius subtypes. J Neurosci 27(41):11103-11. [PubMed: 17928452] [MGI Ref ID J:125693]
Hanashima C; Li SC; Shen L; Lai E; Fishell G. 2004. Foxg1 suppresses early cortical cell fate. Science 303(5654):56-9. [PubMed: 14704420] [MGI Ref ID J:87404]
Hartman BH; Reh TA; Bermingham-McDonogh O. 2010. Notch signaling specifies prosensory domains via lateral induction in the developing mammalian inner ear. Proc Natl Acad Sci U S A 107(36):15792-7. [PubMed: 20798046] [MGI Ref ID J:164376]
Haugas M; Lillevali K; Hakanen J; Salminen M. 2010. Gata2 is required for the development of inner ear semicircular ducts and the surrounding perilymphatic space. Dev Dyn :. [PubMed: 20652952] [MGI Ref ID J:163272]
Hebert JM; Hayhurst M; Marks ME; Kulessa H; Hogan BL; McConnell SK. 2003. BMP ligands act redundantly to pattern the dorsal telencephalic midline. Genesis 35(4):214-9. [PubMed: 12717732] [MGI Ref ID J:83123]
Hebert JM; Lin M; Partanen J; Rossant J; McConnell SK. 2003. FGF signaling through FGFR1 is required for olfactory bulb morphogenesis. Development 130(6):1101-11. [PubMed: 12571102] [MGI Ref ID J:81763]
Hebert JM; Mishina Y; McConnell SK. 2002. BMP signaling is required locally to pattern the dorsal telencephalic midline. Neuron 35(6):1029-41. [PubMed: 12354394] [MGI Ref ID J:79021]
Horwitz GC; Risner-Janiczek JR; Jones SM; Holt JR. 2011. HCN Channels Expressed in the Inner Ear Are Necessary for Normal Balance Function. J Neurosci 31(46):16814-25. [PubMed: 22090507] [MGI Ref ID J:177907]
Hurd EA; Poucher HK; Cheng K; Raphael Y; Martin DM. 2010. The ATP-dependent chromatin remodeling enzyme CHD7 regulates pro-neural gene expression and neurogenesis in the inner ear. Development 137(18):3139-50. [PubMed: 20736290] [MGI Ref ID J:164582]
Hwang CH; Guo D; Harris MA; Howard O; Mishina Y; Gan L; Harris SE; Wu DK. 2010. Role of bone morphogenetic proteins on cochlear hair cell formation: analyses of Noggin and Bmp2 mutant mice. Dev Dyn 239(2):505-13. [PubMed: 20063299] [MGI Ref ID J:156945]
Ivanova E; Hwang GS; Pan ZH. 2010. Characterization of transgenic mouse lines expressing Cre recombinase in the retina. Neuroscience 165(1):233-43. [PubMed: 19837136] [MGI Ref ID J:158209]
Jacques BE; Montcouquiol ME; Layman EM; Lewandoski M; Kelley MW. 2007. Fgf8 induces pillar cell fate and regulates cellular patterning in the mammalian cochlea. Development 134(16):3021-9. [PubMed: 17634195] [MGI Ref ID J:123947]
Jadhav AP; Mason HA; Cepko CL. 2006. Notch 1 inhibits photoreceptor production in the developing mammalian retina. Development 133(5):913-23. [PubMed: 16452096] [MGI Ref ID J:105970]
Jin YR; Han XH; Taketo MM; Yoon JK. 2012. Wnt9b-dependent FGF signaling is crucial for outgrowth of the nasal and maxillary processes during upper jaw and lip development. Development 139(10):1821-30. [PubMed: 22461561] [MGI Ref ID J:184014]
Jones C; Roper VC; Foucher I; Qian D; Banizs B; Petit C; Yoder BK; Chen P. 2008. Ciliary proteins link basal body polarization to planar cell polarity regulation. Nat Genet 40(1):69-77. [PubMed: 18066062] [MGI Ref ID J:131308]
Junghans D; Hack I; Frotscher M; Taylor V; Kemler R. 2005. Beta-catenin-mediated cell-adhesion is vital for embryonic forebrain development. Dev Dyn 233(2):528-39. [PubMed: 15844200] [MGI Ref ID J:129254]
Katayama K; Melendez J; Baumann JM; Leslie JR; Chauhan BK; Nemkul N; Lang RA; Kuan CY; Zheng Y; Yoshida Y. 2011. Loss of RhoA in neural progenitor cells causes the disruption of adherens junctions and hyperproliferation. Proc Natl Acad Sci U S A 108(18):7607-12. [PubMed: 21502507] [MGI Ref ID J:172044]
Kawauchi S; Kim J; Santos R; Wu HH; Lander AD; Calof AL. 2009. Foxg1 promotes olfactory neurogenesis by antagonizing Gdf11. Development 136(9):1453-64. [PubMed: 19297409] [MGI Ref ID J:147995]
Kawauchi S; Shou J; Santos R; Hebert JM; McConnell SK; Mason I; Calof AL. 2005. Fgf8 expression defines a morphogenetic center required for olfactory neurogenesis and nasal cavity development in the mouse. Development 132(23):5211-23. [PubMed: 16267092] [MGI Ref ID J:103123]
Kelly MC; Chang Q; Pan A; Lin X; Chen P. 2012. Atoh1 directs the formation of sensory mosaics and induces cell proliferation in the postnatal Mammalian cochlea in vivo. J Neurosci 32(19):6699-710. [PubMed: 22573692] [MGI Ref ID J:184847]
Kernohan KD; Jiang Y; Tremblay DC; Bonvissuto AC; Eubanks JH; Mann MR; Berube NG. 2010. ATRX partners with cohesin and MeCP2 and contributes to developmental silencing of imprinted genes in the brain. Dev Cell 18(2):191-202. [PubMed: 20159591] [MGI Ref ID J:158584]
Kersigo J; D'Angelo A; Gray BD; Soukup GA; Fritzsch B. 2011. The role of sensory organs and the forebrain for the development of the craniofacial shape as revealed by Foxg1-cre-mediated microRNA loss. Genesis 49(4):326-41. [PubMed: 21225654] [MGI Ref ID J:171536]
Kiernan AE; Cordes R; Kopan R; Gossler A; Gridley T. 2005. The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear. Development 132(19):4353-62. [PubMed: 16141228] [MGI Ref ID J:132241]
Kiernan AE; Xu J; Gridley T. 2006. The Notch ligand JAG1 is required for sensory progenitor development in the mammalian inner ear. PLoS Genet 2(1):e4. [PubMed: 16410827] [MGI Ref ID J:115783]
Li Y; Gordon J; Manley NR; Litingtung Y; Chiang C. 2008. Bmp4 is required for tracheal formation: a novel mouse model for tracheal agenesis. Dev Biol 322(1):145-55. [PubMed: 18692041] [MGI Ref ID J:142133]
Li Y; Hibbs MA; Gard AL; Shylo NA; Yun K. 2012. Genome-wide analysis of N1ICD/RBPJ targets in vivo reveals direct transcriptional regulation of Wnt, SHH, and hippo pathway effectors by Notch1. Stem Cells 30(4):741-52. [PubMed: 22232070] [MGI Ref ID J:190509]
Li Y; Yui D; Luikart BW; McKay RM; Li Y; Rubenstein JL; Parada LF. 2012. Conditional ablation of brain-derived neurotrophic factor-TrkB signaling impairs striatal neuron development. Proc Natl Acad Sci U S A 109(38):15491-6. [PubMed: 22949667] [MGI Ref ID J:190151]
Lopez-Bendito G; Cautinat A; Sanchez JA; Bielle F; Flames N; Garratt AN; Talmage DA; Role LW; Charnay P; Marin O; Garel S. 2006. Tangential neuronal migration controls axon guidance: a role for neuregulin-1 in thalamocortical axon navigation. Cell 125(1):127-42. [PubMed: 16615895] [MGI Ref ID J:144312]
Lyu YL; Wang JC. 2003. Aberrant lamination in the cerebral cortex of mouse embryos lacking DNA topoisomerase IIbeta. Proc Natl Acad Sci U S A 100(12):7123-8. [PubMed: 12773624] [MGI Ref ID J:94879]
Ma L; Harada T; Harada C; Romero M; Hebert JM; McConnell SK; Parada LF. 2002. Neurotrophin-3 is required for appropriate establishment of thalamocortical connections. Neuron 36(4):623-34. [PubMed: 12441052] [MGI Ref ID J:81563]
Maier E; von Hofsten J; Nord H; Fernandes M; Paek H; Hebert JM; Gunhaga L. 2010. Opposing Fgf and Bmp activities regulate the specification of olfactory sensory and respiratory epithelial cell fates. Development 137(10):1601-11. [PubMed: 20392740] [MGI Ref ID J:160372]
Manuel M; Martynoga B; Yu T; West JD; Mason JO; Price DJ. 2010. The transcription factor Foxg1 regulates the competence of telencephalic cells to adopt subpallial fates in mice. Development 137(3):487-97. [PubMed: 20081193] [MGI Ref ID J:156171]
Manuel MN; Martynoga B; Molinek MD; Quinn JC; Kroemmer C; Mason JO; Price DJ. 2011. The transcription factor Foxg1 regulates telencephalic progenitor proliferation cell autonomously, in part by controlling Pax6 expression levels. Neural Dev 6:9. [PubMed: 21418559] [MGI Ref ID J:171704]
Martynoga B; Morrison H; Price DJ; Mason JO. 2005. Foxg1 is required for specification of ventral telencephalon and region-specific regulation of dorsal telencephalic precursor proliferation and apoptosis. Dev Biol 283(1):113-27. [PubMed: 15893304] [MGI Ref ID J:99329]
Mason HA; Rakowiecki SM; Gridley T; Fishell G. 2006. Loss of notch activity in the developing central nervous system leads to increased cell death. Dev Neurosci 28(1-2):49-57. [PubMed: 16508303] [MGI Ref ID J:112183]
Mason HA; Rakowiecki SM; Raftopoulou M; Nery S; Huang Y; Gridley T; Fishell G. 2005. Notch signaling coordinates the patterning of striatal compartments. Development 132(19):4247-58. [PubMed: 16120638] [MGI Ref ID J:101735]
McClellan KA; Ruzhynsky VA; Douda DN; Vanderluit JL; Ferguson KL; Chen D; Bremner R; Park DS; Leone G; Slack RS. 2007. Unique requirement for Rb/E2F3 in neuronal migration: evidence for cell cycle-independent functions. Mol Cell Biol 27(13):4825-43. [PubMed: 17452454] [MGI Ref ID J:122733]
McClellan KA; Vanderluit JL; Julian LM; Andrusiak MG; Dugal-Tessier D; Park DS; Slack RS. 2009. The p107/E2F pathway regulates fibroblast growth factor 2 responsiveness in neural precursor cells. Mol Cell Biol 29(17):4701-13. [PubMed: 19564414] [MGI Ref ID J:152616]
Muzio L; Mallamaci A. 2005. Foxg1 confines Cajal-Retzius neuronogenesis and hippocampal morphogenesis to the dorsomedial pallium. J Neurosci 25(17):4435-41. [PubMed: 15858069] [MGI Ref ID J:98698]
Nowakowski TJ; Mysiak KS; Pratt T; Price DJ. 2011. Functional dicer is necessary for appropriate specification of radial glia during early development of mouse telencephalon. PLoS One 6(8):e23013. [PubMed: 21826226] [MGI Ref ID J:176531]
O'Hara L; Welsh M; Saunders PT; Smith LB. 2011. Androgen receptor expression in the caput epididymal epithelium is essential for development of the initial segment and epididymal spermatozoa transit. Endocrinology 152(2):718-29. [PubMed: 21177831] [MGI Ref ID J:173889]
Paek H; Antoine MW; Diaz F; Hebert JM. 2012. Increased beta-catenin activity in the anterior neural plate induces ectopic mid-hindbrain characteristics. Dev Dyn 241(2):242-6. [PubMed: 22102609] [MGI Ref ID J:179736]
Paek H; Gutin G; Hebert JM. 2009. FGF signaling is strictly required to maintain early telencephalic precursor cell survival. Development 136(14):2457-65. [PubMed: 19542358] [MGI Ref ID J:150347]
Pan W; Jin Y; Stanger B; Kiernan AE. 2010. Notch signaling is required for the generation of hair cells and supporting cells in the mammalian inner ear. Proc Natl Acad Sci U S A 107(36):15798-803. [PubMed: 20733081] [MGI Ref ID J:164383]
Park HJ; Hong M; Bronson RT; Israel MA; Frankel WN; Yun K. 2013. Elevated id2 expression results in precocious neural stem cell depletion and abnormal brain development. Stem Cells 31(5):1010-21. [PubMed: 23390122] [MGI Ref ID J:196308]
Perrin BJ; Sonnemann KJ; Ervasti JM. 2010. beta-actin and gamma-actin are each dispensable for auditory hair cell development but required for Stereocilia maintenance. PLoS Genet 6(10):e1001158. [PubMed: 20976199] [MGI Ref ID J:167543]
Pirvola U; Ylikoski J; Trokovic R; Hebert JM; McConnell SK; Partanen J. 2002. FGFR1 is required for the development of the auditory sensory epithelium. Neuron 35(4):671-80. [PubMed: 12194867] [MGI Ref ID J:78879]
Pratt T; Quinn JC; Simpson TI; West JD; Mason JO; Price DJ. 2002. Disruption of early events in thalamocortical tract formation in mice lacking the transcription factors Pax6 or Foxg1. J Neurosci 22(19):8523-31. [PubMed: 12351726] [MGI Ref ID J:79212]
Pratt T; Tian NM; Simpson TI; Mason JO; Price DJ. 2004. The winged helix transcription factor Foxg1 facilitates retinal ganglion cell axon crossing of the ventral midline in the mouse. Development 131(15):3773-84. [PubMed: 15240555] [MGI Ref ID J:92062]
Puligilla C; Feng F; Ishikawa K; Bertuzzi S; Dabdoub A; Griffith AJ; Fritzsch B; Kelley MW. 2007. Disruption of fibroblast growth factor receptor 3 signaling results in defects in cellular differentiation, neuronal patterning, and hearing impairment. Dev Dyn 236(7):1905-17. [PubMed: 17557302] [MGI Ref ID J:122378]
Qu Y; Tang W; Zhou B; Ahmad S; Chang Q; Li X; Lin X. 2012. Early developmental expression of connexin26 in the cochlea contributes to its dominate functional role in the cochlear gap junctions. Biochem Biophys Res Commun 417(1):245-50. [PubMed: 22142852] [MGI Ref ID J:180311]
Rajaii F; Bitzer ZT; Xu Q; Sockanathan S. 2008. Expression of the dominant negative retinoid receptor, RAR403, alters telencephalic progenitor proliferation, survival, and cell fate specification. Dev Biol 316(2):371-82. [PubMed: 18329011] [MGI Ref ID J:135403]
Rickheit G; Maier H; Strenzke N; Andreescu CE; De Zeeuw CI; Muenscher A; Zdebik AA; Jentsch TJ. 2008. Endocochlear potential depends on Cl- channels: mechanism underlying deafness in Bartter syndrome IV. EMBO J 27(21):2907-17. [PubMed: 18833191] [MGI Ref ID J:143314]
Rodriguez S; Sickles HM; Deleonardis C; Alcaraz A; Gridley T; Lin DM. 2008. Notch2 is required for maintaining sustentacular cell function in the adult mouse main olfactory epithelium. Dev Biol 314(1):40-58. [PubMed: 18155189] [MGI Ref ID J:130929]
Schultz JM; Khan SN; Ahmed ZM; Riazuddin S; Waryah AM; Chhatre D; Starost MF; Ploplis B; Buckley S; Velasquez D; Kabra M; Lee K; Hassan MJ; Ali G; Ansar M; Ghosh M; Wilcox ER; Ahmad W; Merlino G; Leal SM; Riazuddin S; Friedman TB; Morell RJ. 2009. Noncoding mutations of HGF are associated with nonsyndromic hearing loss, DFNB39. Am J Hum Genet 85(1):25-39. [PubMed: 19576567] [MGI Ref ID J:154237]
Seah C; Levy MA; Jiang Y; Mokhtarzada S; Higgs DR; Gibbons RJ; Berube NG. 2008. Neuronal death resulting from targeted disruption of the Snf2 protein ATRX is mediated by p53. J Neurosci 28(47):12570-80. [PubMed: 19020049] [MGI Ref ID J:142359]
Sessa A; Mao CA; Colasante G; Nini A; Klein WH; Broccoli V. 2010. Tbr2-positive intermediate (basal) neuronal progenitors safeguard cerebral cortex expansion by controlling amplification of pallial glutamatergic neurons and attraction of subpallial GABAergic interneurons. Genes Dev 24(16):1816-26. [PubMed: 20713522] [MGI Ref ID J:163753]
Sessa A; Mao CA; Hadjantonakis AK; Klein WH; Broccoli V. 2008. Tbr2 directs conversion of radial glia into basal precursors and guides neuronal amplification by indirect neurogenesis in the developing neocortex. Neuron 60(1):56-69. [PubMed: 18940588] [MGI Ref ID J:144650]
Siegenthaler JA; Miller MW. 2008. Generation of Cajal-Retzius neurons in mouse forebrain is regulated by transforming growth factor beta-Fox signaling pathways. Dev Biol 313(1):35-46. [PubMed: 18005957] [MGI Ref ID J:130128]
Siegenthaler JA; Tremper-Wells BA; Miller MW. 2008. Foxg1 haploinsufficiency reduces the population of cortical intermediate progenitor cells: effect of increased p21 expression. Cereb Cortex 18(8):1865-75. [PubMed: 18065723] [MGI Ref ID J:138025]
Sipe CW; Lu X. 2011. Kif3a regulates planar polarization of auditory hair cells through both ciliary and non-ciliary mechanisms. Development 138(16):3441-9. [PubMed: 21752934] [MGI Ref ID J:175534]
Storm EE; Garel S; Borello U; Hebert JM; Martinez S; McConnell SK; Martin GR; Rubenstein JL. 2006. Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers. Development 133(9):1831-44. [PubMed: 16613831] [MGI Ref ID J:108506]
Storm EE; Rubenstein JL; Martin GR. 2003. Dosage of Fgf8 determines whether cell survival is positively or negatively regulated in the developing forebrain. Proc Natl Acad Sci U S A 100(4):1757-62. [PubMed: 12574514] [MGI Ref ID J:111586]
Tavares AL; Garcia EL; Kuhn K; Woods CM; Williams T; Clouthier DE. 2012. Ectodermal-derived Endothelin1 is required for patterning the distal and intermediate domains of the mouse mandibular arch. Dev Biol 371(1):47-56. [PubMed: 22902530] [MGI Ref ID J:190564]
Theil T; Dominguez-Frutos E; Schimmang T. 2008. Differential requirements for Fgf3 and Fgf8 during mouse forebrain development. Dev Dyn 237(11):3417-23. [PubMed: 18942154] [MGI Ref ID J:140707]
Thomson RE; Kind PC; Graham NA; Etherson ML; Kennedy J; Fernandes AC; Marques CS; Hevner RF; Iwata T. 2009. Fgf receptor 3 activation promotes selective growth and expansion of occipitotemporal cortex. Neural Dev 4:4. [PubMed: 19192266] [MGI Ref ID J:160732]
Tian NM; Pratt T; Price DJ. 2008. Foxg1 regulates retinal axon pathfinding by repressing an ipsilateral program in nasal retina and by causing optic chiasm cells to exert a net axonal growth-promoting activity. Development 135(24):4081-9. [PubMed: 19004857] [MGI Ref ID J:142507]
Tole S; Gutin G; Bhatnagar L; Remedios R; Hebert JM. 2006. Development of midline cell types and commissural axon tracts requires Fgfr1 in the cerebrum. Dev Biol 289(1):141-51. [PubMed: 16309667] [MGI Ref ID J:104160]
Virolainen SM; Achim K; Peltopuro P; Salminen M; Partanen J. 2012. Transcriptional regulatory mechanisms underlying the GABAergic neuron fate in different diencephalic prosomeres. Development 139(20):3795-805. [PubMed: 22991444] [MGI Ref ID J:188110]
Wang Y; Chang Q; Tang W; Sun Y; Zhou B; Li H; Lin X. 2009. Targeted connexin26 ablation arrests postnatal development of the organ of Corti. Biochem Biophys Res Commun 385(1):33-7. [PubMed: 19433060] [MGI Ref ID J:150588]
Wang Y; Martin JF; Bai CB. 2010. Direct and indirect requirements of Shh/Gli signaling in early pituitary development. Dev Biol 348(2):199-209. [PubMed: 20934421] [MGI Ref ID J:166929]
Wang Y; Rattner A; Zhou Y; Williams J; Smallwood PM; Nathans J. 2012. Norrin/Frizzled4 signaling in retinal vascular development and blood brain barrier plasticity. Cell 151(6):1332-44. [PubMed: 23217714] [MGI Ref ID J:193332]
Wang Y; Song L; Zhou CJ. 2011. The canonical Wnt/beta-catenin signaling pathway regulates Fgf signaling for early facial development. Dev Biol 349(2):250-60. [PubMed: 21070765] [MGI Ref ID J:168024]
Weng DY; Zhang Y; Hayashi Y; Kuan CY; Liu CY; Babcock G; Weng WL; Schwemberger S; Kao WW. 2008. Promiscuous recombination of LoxP alleles during gametogenesis in cornea Cre driver mice. Mol Vis 14:562-71. [PubMed: 18385792] [MGI Ref ID J:149921]
Xu H; Viola A; Zhang Z; Gerken CP; Lindsay-Illingworth EA; Baldini A. 2007. Tbx1 regulates population, proliferation and cell fate determination of otic epithelial cells. Dev Biol 302(2):670-82. [PubMed: 17074316] [MGI Ref ID J:119950]
Xu P; Das M; Reilly J; Davis RJ. 2011. JNK regulates FoxO-dependent autophagy in neurons. Genes Dev 25(4):310-22. [PubMed: 21325132] [MGI Ref ID J:169060]
Yamamoto N; Chang W; Kelley MW. 2011. Rbpj regulates development of prosensory cells in the mammalian inner ear. Dev Biol 353(2):367-79. [PubMed: 21420948] [MGI Ref ID J:173796]
Yamamoto N; Okano T; Ma X; Adelstein RS; Kelley MW. 2009. Myosin II regulates extension, growth and patterning in the mammalian cochlear duct. Development 136(12):1977-86. [PubMed: 19439495] [MGI Ref ID J:149532]
Yip DJ; Corcoran CP; Alvarez-Saavedra M; DeMaria A; Rennick S; Mears AJ; Rudnicki MA; Messier C; Picketts DJ. 2012. Snf2l regulates Foxg1-dependent progenitor cell expansion in the developing brain. Dev Cell 22(4):871-8. [PubMed: 22516202] [MGI Ref ID J:183998]
Yue T; Xian K; Hurlock E; Xin M; Kernie SG; Parada LF; Lu QR. 2006. A critical role for dorsal progenitors in cortical myelination. J Neurosci 26(4):1275-80. [PubMed: 16436615] [MGI Ref ID J:105071]
Zelarayan LC; Vendrell V; Alvarez Y; Dominguez-Frutos E; Theil T; Alonso MT; Maconochie M; Schimmang T. 2007. Differential requirements for FGF3, FGF8 and FGF10 during inner ear development. Dev Biol 308(2):379-91. [PubMed: 17601531] [MGI Ref ID J:124118]
Zembrzycki A; Griesel G; Stoykova A; Mansouri A. 2007. Genetic interplay between the transcription factors Sp8 and Emx2 in the patterning of the forebrain. Neural Dev 2:8. [PubMed: 17470284] [MGI Ref ID J:160653]
Zhang Z; Cerrato F; Xu H; Vitelli F; Morishima M; Vincentz J; Furuta Y; Ma L; Martin JF; Baldini A; Lindsay E. 2005. Tbx1 expression in pharyngeal epithelia is necessary for pharyngeal arch artery development. Development 132(23):5307-15. [PubMed: 16284121] [MGI Ref ID J:102843]
Zhou L; Bar I; Achouri Y; Campbell K; De Backer O; Hebert JM; Jones K; Kessaris N; de Rouvroit CL; O'Leary D; Richardson WD; Goffinet AM; Tissir F. 2008. Early forebrain wiring: genetic dissection using conditional Celsr3 mutant mice. Science 320(5878):946-9. [PubMed: 18487195] [MGI Ref ID J:134879]
Zhou L; Qu Y; Tissir F; Goffinet AM. 2009. Role of the atypical cadherin Celsr3 during development of the internal capsule. Cereb Cortex 19 Suppl 1:i114-9. [PubMed: 19349379] [MGI Ref ID J:161098]
Zimmer C; Lee J; Griveau A; Arber S; Pierani A; Garel S; Guillemot F. 2010. Role of Fgf8 signalling in the specification of rostral Cajal-Retzius cells. Development 137(2):293-302. [PubMed: 20040495] [MGI Ref ID J:157253]
Health & husbandry
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Health & Colony Maintenance Information
Animal Health Reports
Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.Colony Maintenance
Breeding & Husbandry When maintaining a live colony, these mice are bred as heterozygotes. Diet Information LabDiet® 5K52/5K67
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
|
Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $2450.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
| Pricing for International shipping destinations |
|
Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $3185.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
|
|
|
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| Wild-type from the colony | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form
Terms of Use
Terms of Use
General Terms and Conditions
For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.
Contact information
General inquiries regarding Terms of UseContracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.