| |||||||||||||||
- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Former Names 129.Cg-Foxg1tm1(cre)Skm/J (Changed: 29-AUG-08 ) STOCK Foxg1tm1(cre)Skm (Changed: 15-DEC-04 ) STOCK-Foxg1tm1(Cre)Skm (Changed: 15-DEC-04 ) Type Congenic; Mutant Strain; Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Inbred x Heterozygote (Female x Male) 01-MAR-06 Species laboratory mouse Generation N9+N1F2N10 (22-JAN-09) Donating Investigator Susan McConnell, Stanford University Description
This strain expresses Cre recombinase from the endogenous Foxg1 locus. Forkhead box G1 is required for telencephalon development and is expressed specifically in the telencephalon and discrete head structures. When crossed with a strain containing loxP site flanked sequence of interest, Cre-mediated recombination results in tissue-specific deletion of the target. Recombination occurs in the telencephalon, anterior optic vesicle (developing lens and retina), otic vesicle, facial and head ectoderm, olfactory epithelium, mid-hindbrain junction and pharyngeal pouches. Mice that are homozygous for the targeted mutation die perinatally. Heterozygous mutant mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. This mutant mouse strain represents a model that may be useful in studies of telencephalic development.Development
A targeting vector containing cre coding sequence, neomycin resistance and herpes simplex virus thymidine kinase genes was used to disrupt most of the coding sequence the targeted gene. The endogenous Foxg1 promoter drives expression of the Cre recombinase through the in-frame insertion of the cre coding sequence to the first 13 codons of the Foxg1 gene. The construct was electroporated into 129P2/OlaHsd-Hprtb-m1 derived HM-1 embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6 blastocysts. The resulting chimeric animals were initially backcrossed to Swiss Webster mice, then backcrossed for 9 generations on a 129 background.
Control Information
| Control | ||
|---|---|---|
| Wild-type from the colony | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Foxg1tm1(cre)Skm allele
006084 B6.129P2(Cg)-Foxg1tm1(cre)Skm/J View Strains carrying Foxg1tm1(cre)Skm (1 strain)
Additional Web Information
Genetic Quality Control Annual Report
Introduction to Cre-lox technology
Phenotype
Phenotype Information
assigned by genotype
Foxg1tm1(cre)Skm/Foxg1+
129(Cg)-Foxg1tm1(cre)Skm/J
- normal phenotype
- no abnormal phenotype detected (MGI Ref ID J:62916)
- heterozygous mutant mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities
Foxg1tm1(cre)Skm/Foxg1tm1(cre)Skm
129(Cg)-Foxg1tm1(cre)Skm/J
- lethality-prenatal/perinatal
- perinatal lethality (MGI Ref ID J:62916)
- homozygous mice die perinatally
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Foxg1tm1(cre)Skm/Foxg1+
B6.129P2-Foxg1tm1(cre)Skm
- nervous system phenotype
- abnormal brain morphology (MGI Ref ID J:128207)
- length of the medio-lateral and midline anterior-posterior axes of the cerebral hemispheres is reduced
- reduction in dimensions of cerebral hemispheres is observed by postnatal day 4
- area of cortical sheet is reduced at postnatal day 8 and in adult brain
- abnormal forebrain morphology (MGI Ref ID J:128207)
- volume of prosencephalon is reduced by 23%
- abnormal telencephalon morphology (MGI Ref ID J:128207)
- abnormal cerebral cortex morphology (MGI Ref ID J:128207)
- volume of cerebral cortex is reduced by 40.7%
- radial domain of cerebral cortex is substantially disrupted, especially in supragranular layers
- thickness of supragranular layer is reduced by 41.4% although granular and infragranular layers are not reduced
- decreased pyramidal neuron number (MGI Ref ID J:128207)
- numbers of large and medium sized neurons are reduced in superficial layers of cortex
- thin cerebral cortex (MGI Ref ID J:128207)
- thinning is observed only in C57BL/6 background, not in mixed C57BL/6 and CBA background
- abnormal hippocampus size (MGI Ref ID J:128207)
- volume of hippocampus is reduced by 18.6%
- abnormal striatum morphology (MGI Ref ID J:128207)
- volume of striatum is reduced by 29.7%
- abnormal thalamus morphology (MGI Ref ID J:128207)
- in adult, volume of thalamus is reduced by 21.6%, however at postnatal day 4, volume is not reduced
- total number of cells is reduced in levels 1 and 2 of the ventrobasal complex
- forebrain hypoplasia (MGI Ref ID J:128207)
Foxg1tm1(cre)Skm/Foxg1+
involves: C57BL/6 * CBA
- nervous system phenotype
- abnormal brain morphology (MGI Ref ID J:128207)
- reduction in dimensions of cerebral hemispheres is observed by postnatal day 4, however, on the mixed background the substantial reductions reported in the C57BL/6J forebrain are not observed
This mouse can be used to support research in many areas including:
cre relatedNeurobiology Research
Cre-lox System
Cre Recombinase expression in neural tissue
Research Tools
Cre-lox System
Cre Recombinase Expression
Developmental Biology Research
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis: Cre-lox System
Tissue/Cell Markers: Cre-lox System
Tissue/Cell Markers: astrocytes, neurons
Neurobiology Research
Foxg1tm1(cre)Skm relatedResearch Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis: Cre-lox System
Developmental Biology Research
Cell Motility Defects
Craniofacial and Palate Defects
Defects in Cell Adhesion Molecules
Defects in Extracellular Matrix Molecules
Neural Crest Defects
Neural Tube Defects
Neurodevelopmental Defects
Neurobiology Research
Astrocyte Defects
Cortical Defects
Neural Tube Defects
Neurodevelopmental Defects
Neurotrophic Factor Defects
Vestibular and Hearing Defects
Sensorineural Research
Eye Defects
Olfactory Defects
Retinal Degeneration
Vestibular and Hearing Defects
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Foxg1tm1(cre)Skm | ||
|---|---|---|---|
| Allele Name | targeted mutation 1, Susan K McConnell | ||
| Allele Type | Targeted (knock-in) | ||
| Common Name(s) | BF1-cre; Foxg1-; Foxg1-Cre; Foxg1:Cre; Foxg1Cre; Foxg1KiCre; TgH(Foxg1-Cre)1Skm; | ||
| Mutation Made By | Susan McConnell, Stanford University | ||
| Strain of Origin | 129P2/OlaHsd-Hprt1 | ||
| ES Cell Line Name | HM-1 | ||
| ES Cell Line Strain | 129P2/OlaHsd-Hprt1 | ||
| Site of Expression | telencephalon, anterior optic vesicle (developing lens and retina), otic vesicle, facial and head ectoderm, olfactory epithelium, mid-hindbrain junction and pharyngeal pouches | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Gene Symbol and Name | Foxg1, forkhead box G1 | ||
| Chromosome | 12 | ||
| Gene Common Name(s) | 2900064B05Rik; BF-1; BF1; BF1A; BF2; FHKL3; FKH2; FKHL1; FKHL2; FKHL3; FKHL4; FOXG1A; FOXG1B; FOXG1C; HBF-1; HBF-2; HBF-3; HBF-G2; HBF2; HFK1; HFK2; HFK3; HNF-3/forkhead homolog, brain factor 1; Hfh9; Hfhbf1; KHL2; QIN; RATBF1A; RIKEN cDNA 2900064B05 gene; | ||
| Driver Note | Foxg1 | ||
| General Note | Cre mediated recombination was demonstrated in 3 reporter mouse lines in the following tissues: telencephalon, anterior optic vesicle, otic vesicle, facial and head ectoderm, olfactory epithelium, mid-hindbrain junction, and pharyngeal pouches. | ||
| Molecular Note | Most of the coding region was replaced with a cre gene and a neomycin cassette. The cre gene sequence was fused in-frame following the first 13 codons of the gene. The endogenous promoter is active in telencephalon, anterior optic vesicle, otic vesicle, facial and head ectoderm, olfactory epithelium, mid-hindbrain junction and pharyngeal pouches. [MGI Ref ID J:62916] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Foxg1tm1(cre)Skm, Separated PCR
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Hebert JM; McConnell SK. 2000. Targeting of cre to the Foxg1 (BF-1) locus mediates loxP recombination in the telencephalon and other developing head structures. Dev Biol 222(2):296-306. [PubMed: 10837119] [MGI Ref ID J:62916]
Additional References
Ferguson KL; Vanderluit JL; Hebert JM; McIntosh WC; Tibbo E; MacLaurin JG; Park DS; Wallace VA; Vooijs M; McConnell SK; Slack RS. 2002. Telencephalon-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal cortical development. EMBO J 21(13):3337-46. [PubMed: 12093735] [MGI Ref ID J:77762]
Hebert JM; Hayhurst M; Marks ME; Kulessa H; Hogan BL; McConnell SK. 2003. BMP ligands act redundantly to pattern the dorsal telencephalic midline. Genesis 35(4):214-9. [PubMed: 12717732] [MGI Ref ID J:83123]
Hebert JM; Mishina Y; McConnell SK. 2002. BMP signaling is required locally to pattern the dorsal telencephalic midline. Neuron 35(6):1029-41. [PubMed: 12354394] [MGI Ref ID J:79021]
Ma L; Harada T; Harada C; Romero M; Hebert JM; McConnell SK; Parada LF. 2002. Neurotrophin-3 is required for appropriate establishment of thalamocortical connections. Neuron 36(4):623-34. [PubMed: 12441052] [MGI Ref ID J:81563]
Foxg1tm1(cre)Skm relatedAhrens MJ; Li Y; Jiang H; Dudley AT. 2009. Convergent extension movements in growth plate chondrocytes require gpi-anchored cell surface proteins. Development 136(20):3463-74. [PubMed: 19762422] [MGI Ref ID J:153618]
Anthony TE; Mason HA; Gridley T; Fishell G; Heintz N. 2005. Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells. Genes Dev 19(9):1028-33. [PubMed: 15879553] [MGI Ref ID J:98262]
Arbour N; Vanderluit JL; Le Grand JN; Jahani-Asl A; Ruzhynsky VA; Cheung EC; Kelly MA; MacKenzie AE; Park DS; Opferman JT; Slack RS. 2008. Mcl-1 is a key regulator of apoptosis during CNS development and after DNA damage. J Neurosci 28(24):6068-78. [PubMed: 18550749] [MGI Ref ID J:137346]
Arnold JS; Braunstein EM; Ohyama T; Groves AK; Adams JC; Brown MC; Morrow BE. 2006. Tissue-specific roles of Tbx1 in the development of the outer, middle and inner ear, defective in 22q11DS patients. Hum Mol Genet 15(10):1629-39. [PubMed: 16600992] [MGI Ref ID J:109536]
Arnold JS; Werling U; Braunstein EM; Liao J; Nowotschin S; Edelmann W; Hebert JM; Morrow BE. 2006. Inactivation of Tbx1 in the pharyngeal endoderm results in 22q11DS malformations. Development 133(5):977-87. [PubMed: 16452092] [MGI Ref ID J:105980]
Barrionuevo F; Naumann A; Bagheri-Fam S; Speth V; Taketo MM; Scherer G; Neubuser A. 2008. Sox9 is required for invagination of the otic placode in mice. Dev Biol 317(1):213-24. [PubMed: 18377888] [MGI Ref ID J:136177]
Berube NG; Mangelsdorf M; Jagla M; Vanderluit J; Garrick D; Gibbons RJ; Higgs DR; Slack RS; Picketts DJ. 2005. The chromatin-remodeling protein ATRX is critical for neuronal survival during corticogenesis. J Clin Invest 115(2):258-67. [PubMed: 15668733] [MGI Ref ID J:95953]
Bobola N; Carapuco M; Ohnemus S; Kanzler B; Leibbrandt A; Neubuser A; Drouin J; Mallo M. 2003. Mesenchymal patterning by Hoxa2 requires blocking Fgf-dependent activation of Ptx1. Development 130(15):3403-14. [PubMed: 12810588] [MGI Ref ID J:83660]
Brooker R; Hozumi K; Lewis J. 2006. Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear. Development 133(7):1277-86. [PubMed: 16495313] [MGI Ref ID J:107414]
Chang W; Lin Z; Kulessa H; Hebert J; Hogan BL; Wu DK. 2008. Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movements. PLoS Genet 4(4):e1000050. [PubMed: 18404215] [MGI Ref ID J:136636]
Chen L; Liao G; Waclaw RR; Burns KA; Linquist D; Campbell K; Zheng Y; Kuan CY. 2007. Rac1 controls the formation of midline commissures and the competency of tangential migration in ventral telencephalic neurons. J Neurosci 27(14):3884-93. [PubMed: 17409253] [MGI Ref ID J:121201]
Chen L; Liao G; Yang L; Campbell K; Nakafuku M; Kuan CY; Zheng Y. 2006. Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly. Proc Natl Acad Sci U S A 103(44):16520-5. [PubMed: 17050694] [MGI Ref ID J:116100]
Chen L; Melendez J; Campbell K; Kuan CY; Zheng Y. 2009. Rac1 deficiency in the forebrain results in neural progenitor reduction and microcephaly. Dev Biol 325(1):162-70. [PubMed: 19007770] [MGI Ref ID J:143541]
Cheung EC; Joza N; Steenaart NA; McClellan KA; Neuspiel M; McNamara S; MacLaurin JG; Rippstein P; Park DS; Shore GC; McBride HM; Penninger JM; Slack RS. 2006. Dissociating the dual roles of apoptosis-inducing factor in maintaining mitochondrial structure and apoptosis. EMBO J 25(17):4061-73. [PubMed: 16917506] [MGI Ref ID J:112874]
Duggan CD; Demaria S; Baudhuin A; Stafford D; Ngai J. 2008. Foxg1 is required for development of the vertebrate olfactory system. J Neurosci 28(20):5229-39. [PubMed: 18480279] [MGI Ref ID J:136319]
Eagleson KL; Schlueter McFadyen-Ketchum LJ; Ahrens ET; Mills PH; Does MD; Nickols J; Levitt P. 2007. Disruption of Foxg1 expression by knock-in of cre recombinase: effects on the development of the mouse telencephalon. Neuroscience 148(2):385-99. [PubMed: 17640820] [MGI Ref ID J:128207]
Ferguson KL; Vanderluit JL; Hebert JM; McIntosh WC; Tibbo E; MacLaurin JG; Park DS; Wallace VA; Vooijs M; McConnell SK; Slack RS. 2002. Telencephalon-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal cortical development. EMBO J 21(13):3337-46. [PubMed: 12093735] [MGI Ref ID J:77762]
Fernandes M; Gutin G; Alcorn H; McConnell SK; Hebert JM. 2007. Mutations in the BMP pathway in mice support the existence of two molecular classes of holoprosencephaly. Development 134(21):3789-94. [PubMed: 17913790] [MGI Ref ID J:126436]
Ferrer-Vaquer A; Maurey P; Firnberg N; Leibbrandt A; Neubuser A. 2007. Expression of ASK1 during chick and early mouse development. Gene Expr Patterns 7(7):808-16. [PubMed: 17602894] [MGI Ref ID J:123567]
Flames N; Long JE; Garratt AN; Fischer TM; Gassmann M; Birchmeier C; Lai C; Rubenstein JL; Marin O. 2004. Short- and long-range attraction of cortical GABAergic interneurons by neuregulin-1. Neuron 44(2):251-61. [PubMed: 15473965] [MGI Ref ID J:130617]
Fuccillo M; Rallu M; McMahon AP; Fishell G. 2004. Temporal requirement for hedgehog signaling in ventral telencephalic patterning. Development 131(20):5031-40. [PubMed: 15371303] [MGI Ref ID J:93609]
Geng X; Speirs C; Lagutin O; Inbal A; Liu W; Solnica-Krezel L; Jeong Y; Epstein DJ; Oliver G. 2008. Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly. Dev Cell 15(2):236-47. [PubMed: 18694563] [MGI Ref ID J:140315]
Gutin G; Fernandes M; Palazzolo L; Paek H; Yu K; Ornitz DM; McConnell SK; Hebert JM. 2006. FGF signalling generates ventral telencephalic cells independently of SHH. Development 133(15):2937-46. [PubMed: 16818446] [MGI Ref ID J:119019]
Hanashima C; Fernandes M; Hebert JM; Fishell G. 2007. The role of Foxg1 and dorsal midline signaling in the generation of Cajal-Retzius subtypes. J Neurosci 27(41):11103-11. [PubMed: 17928452] [MGI Ref ID J:125693]
Hanashima C; Li SC; Shen L; Lai E; Fishell G. 2004. Foxg1 suppresses early cortical cell fate. Science 303(5654):56-9. [PubMed: 14704420] [MGI Ref ID J:87404]
Hebert JM; Hayhurst M; Marks ME; Kulessa H; Hogan BL; McConnell SK. 2003. BMP ligands act redundantly to pattern the dorsal telencephalic midline. Genesis 35(4):214-9. [PubMed: 12717732] [MGI Ref ID J:83123]
Hebert JM; Lin M; Partanen J; Rossant J; McConnell SK. 2003. FGF signaling through FGFR1 is required for olfactory bulb morphogenesis. Development 130(6):1101-11. [PubMed: 12571102] [MGI Ref ID J:81763]
Hebert JM; Mishina Y; McConnell SK. 2002. BMP signaling is required locally to pattern the dorsal telencephalic midline. Neuron 35(6):1029-41. [PubMed: 12354394] [MGI Ref ID J:79021]
Jacques BE; Montcouquiol ME; Layman EM; Lewandoski M; Kelley MW. 2007. Fgf8 induces pillar cell fate and regulates cellular patterning in the mammalian cochlea. Development 134(16):3021-9. [PubMed: 17634195] [MGI Ref ID J:123947]
Jadhav AP; Mason HA; Cepko CL. 2006. Notch 1 inhibits photoreceptor production in the developing mammalian retina. Development 133(5):913-23. [PubMed: 16452096] [MGI Ref ID J:105970]
Jones C; Roper VC; Foucher I; Qian D; Banizs B; Petit C; Yoder BK; Chen P. 2008. Ciliary proteins link basal body polarization to planar cell polarity regulation. Nat Genet 40(1):69-77. [PubMed: 18066062] [MGI Ref ID J:131308]
Junghans D; Hack I; Frotscher M; Taylor V; Kemler R. 2005. Beta-catenin-mediated cell-adhesion is vital for embryonic forebrain development. Dev Dyn 233(2):528-39. [PubMed: 15844200] [MGI Ref ID J:129254]
Kawauchi S; Kim J; Santos R; Wu HH; Lander AD; Calof AL. 2009. Foxg1 promotes olfactory neurogenesis by antagonizing Gdf11. Development 136(9):1453-64. [PubMed: 19297409] [MGI Ref ID J:147995]
Kawauchi S; Shou J; Santos R; Hebert JM; McConnell SK; Mason I; Calof AL. 2005. Fgf8 expression defines a morphogenetic center required for olfactory neurogenesis and nasal cavity development in the mouse. Development 132(23):5211-23. [PubMed: 16267092] [MGI Ref ID J:103123]
Kiernan AE; Cordes R; Kopan R; Gossler A; Gridley T. 2005. The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear. Development 132(19):4353-62. [PubMed: 16141228] [MGI Ref ID J:132241]
Kiernan AE; Xu J; Gridley T. 2006. The Notch ligand JAG1 is required for sensory progenitor development in the mammalian inner ear. PLoS Genet 2(1):e4. [PubMed: 16410827] [MGI Ref ID J:115783]
Li Y; Gordon J; Manley NR; Litingtung Y; Chiang C. 2008. Bmp4 is required for tracheal formation: a novel mouse model for tracheal agenesis. Dev Biol 322(1):145-55. [PubMed: 18692041] [MGI Ref ID J:142133]
Lopez-Bendito G; Cautinat A; Sanchez JA; Bielle F; Flames N; Garratt AN; Talmage DA; Role LW; Charnay P; Marin O; Garel S. 2006. Tangential neuronal migration controls axon guidance: a role for neuregulin-1 in thalamocortical axon navigation. Cell 125(1):127-42. [PubMed: 16615895] [MGI Ref ID J:144312]
Lyu YL; Wang JC. 2003. Aberrant lamination in the cerebral cortex of mouse embryos lacking DNA topoisomerase IIbeta. Proc Natl Acad Sci U S A 100(12):7123-8. [PubMed: 12773624] [MGI Ref ID J:94879]
Ma L; Harada T; Harada C; Romero M; Hebert JM; McConnell SK; Parada LF. 2002. Neurotrophin-3 is required for appropriate establishment of thalamocortical connections. Neuron 36(4):623-34. [PubMed: 12441052] [MGI Ref ID J:81563]
Martynoga B; Morrison H; Price DJ; Mason JO. 2005. Foxg1 is required for specification of ventral telencephalon and region-specific regulation of dorsal telencephalic precursor proliferation and apoptosis. Dev Biol 283(1):113-27. [PubMed: 15893304] [MGI Ref ID J:99329]
Mason HA; Rakowiecki SM; Gridley T; Fishell G. 2006. Loss of notch activity in the developing central nervous system leads to increased cell death. Dev Neurosci 28(1-2):49-57. [PubMed: 16508303] [MGI Ref ID J:112183]
Mason HA; Rakowiecki SM; Raftopoulou M; Nery S; Huang Y; Gridley T; Fishell G. 2005. Notch signaling coordinates the patterning of striatal compartments. Development 132(19):4247-58. [PubMed: 16120638] [MGI Ref ID J:101735]
McClellan KA; Ruzhynsky VA; Douda DN; Vanderluit JL; Ferguson KL; Chen D; Bremner R; Park DS; Leone G; Slack RS. 2007. Unique requirement for Rb/E2F3 in neuronal migration: evidence for cell cycle-independent functions. Mol Cell Biol 27(13):4825-43. [PubMed: 17452454] [MGI Ref ID J:122733]
McClellan KA; Vanderluit JL; Julian LM; Andrusiak MG; Dugal-Tessier D; Park DS; Slack RS. 2009. The p107/E2F pathway regulates fibroblast growth factor 2 responsiveness in neural precursor cells. Mol Cell Biol 29(17):4701-13. [PubMed: 19564414] [MGI Ref ID J:152616]
Muzio L; Mallamaci A. 2005. Foxg1 confines Cajal-Retzius neuronogenesis and hippocampal morphogenesis to the dorsomedial pallium. J Neurosci 25(17):4435-41. [PubMed: 15858069] [MGI Ref ID J:98698]
Paek H; Gutin G; Hebert JM. 2009. FGF signaling is strictly required to maintain early telencephalic precursor cell survival. Development 136(14):2457-65. [PubMed: 19542358] [MGI Ref ID J:150347]
Pirvola U; Ylikoski J; Trokovic R; Hebert JM; McConnell SK; Partanen J. 2002. FGFR1 is required for the development of the auditory sensory epithelium. Neuron 35(4):671-80. [PubMed: 12194867] [MGI Ref ID J:78879]
Pratt T; Quinn JC; Simpson TI; West JD; Mason JO; Price DJ. 2002. Disruption of early events in thalamocortical tract formation in mice lacking the transcription factors Pax6 or Foxg1. J Neurosci 22(19):8523-31. [PubMed: 12351726] [MGI Ref ID J:79212]
Pratt T; Tian NM; Simpson TI; Mason JO; Price DJ. 2004. The winged helix transcription factor Foxg1 facilitates retinal ganglion cell axon crossing of the ventral midline in the mouse. Development 131(15):3773-84. [PubMed: 15240555] [MGI Ref ID J:92062]
Puligilla C; Feng F; Ishikawa K; Bertuzzi S; Dabdoub A; Griffith AJ; Fritzsch B; Kelley MW. 2007. Disruption of fibroblast growth factor receptor 3 signaling results in defects in cellular differentiation, neuronal patterning, and hearing impairment. Dev Dyn 236(7):1905-17. [PubMed: 17557302] [MGI Ref ID J:122378]
Rajaii F; Bitzer ZT; Xu Q; Sockanathan S. 2008. Expression of the dominant negative retinoid receptor, RAR403, alters telencephalic progenitor proliferation, survival, and cell fate specification. Dev Biol 316(2):371-82. [PubMed: 18329011] [MGI Ref ID J:135403]
Rickheit G; Maier H; Strenzke N; Andreescu CE; De Zeeuw CI; Muenscher A; Zdebik AA; Jentsch TJ. 2008. Endocochlear potential depends on Cl- channels: mechanism underlying deafness in Bartter syndrome IV. EMBO J 27(21):2907-17. [PubMed: 18833191] [MGI Ref ID J:143314]
Rodriguez S; Sickles HM; Deleonardis C; Alcaraz A; Gridley T; Lin DM. 2008. Notch2 is required for maintaining sustentacular cell function in the adult mouse main olfactory epithelium. Dev Biol 314(1):40-58. [PubMed: 18155189] [MGI Ref ID J:130929]
Seah C; Levy MA; Jiang Y; Mokhtarzada S; Higgs DR; Gibbons RJ; Berube NG. 2008. Neuronal death resulting from targeted disruption of the Snf2 protein ATRX is mediated by p53. J Neurosci 28(47):12570-80. [PubMed: 19020049] [MGI Ref ID J:142359]
Sessa A; Mao CA; Hadjantonakis AK; Klein WH; Broccoli V. 2008. Tbr2 directs conversion of radial glia into basal precursors and guides neuronal amplification by indirect neurogenesis in the developing neocortex. Neuron 60(1):56-69. [PubMed: 18940588] [MGI Ref ID J:144650]
Siegenthaler JA; Miller MW. 2008. Generation of Cajal-Retzius neurons in mouse forebrain is regulated by transforming growth factor beta-Fox signaling pathways. Dev Biol 313(1):35-46. [PubMed: 18005957] [MGI Ref ID J:130128]
Siegenthaler JA; Tremper-Wells BA; Miller MW. 2008. Foxg1 haploinsufficiency reduces the population of cortical intermediate progenitor cells: effect of increased p21 expression. Cereb Cortex 18(8):1865-75. [PubMed: 18065723] [MGI Ref ID J:138025]
Storm EE; Garel S; Borello U; Hebert JM; Martinez S; McConnell SK; Martin GR; Rubenstein JL. 2006. Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers. Development 133(9):1831-44. [PubMed: 16613831] [MGI Ref ID J:108506]
Storm EE; Rubenstein JL; Martin GR. 2003. Dosage of Fgf8 determines whether cell survival is positively or negatively regulated in the developing forebrain. Proc Natl Acad Sci U S A 100(4):1757-62. [PubMed: 12574514] [MGI Ref ID J:111586]
Theil T; Dominguez-Frutos E; Schimmang T. 2008. Differential requirements for Fgf3 and Fgf8 during mouse forebrain development. Dev Dyn 237(11):3417-23. [PubMed: 18942154] [MGI Ref ID J:140707]
Tian NM; Pratt T; Price DJ. 2008. Foxg1 regulates retinal axon pathfinding by repressing an ipsilateral program in nasal retina and by causing optic chiasm cells to exert a net axonal growth-promoting activity. Development 135(24):4081-9. [PubMed: 19004857] [MGI Ref ID J:142507]
Tole S; Gutin G; Bhatnagar L; Remedios R; Hebert JM. 2006. Development of midline cell types and commissural axon tracts requires Fgfr1 in the cerebrum. Dev Biol 289(1):141-51. [PubMed: 16309667] [MGI Ref ID J:104160]
Wang Y; Chang Q; Tang W; Sun Y; Zhou B; Li H; Lin X. 2009. Targeted connexin26 ablation arrests postnatal development of the organ of Corti. Biochem Biophys Res Commun 385(1):33-7. [PubMed: 19433060] [MGI Ref ID J:150588]
Weng DY; Zhang Y; Hayashi Y; Kuan CY; Liu CY; Babcock G; Weng WL; Schwemberger S; Kao WW. 2008. Promiscuous recombination of LoxP alleles during gametogenesis in cornea Cre driver mice. Mol Vis 14:562-71. [PubMed: 18385792] [MGI Ref ID J:149921]
Xu H; Viola A; Zhang Z; Gerken CP; Lindsay-Illingworth EA; Baldini A. 2007. Tbx1 regulates population, proliferation and cell fate determination of otic epithelial cells. Dev Biol 302(2):670-82. [PubMed: 17074316] [MGI Ref ID J:119950]
Yamamoto N; Okano T; Ma X; Adelstein RS; Kelley MW. 2009. Myosin II regulates extension, growth and patterning in the mammalian cochlear duct. Development 136(12):1977-86. [PubMed: 19439495] [MGI Ref ID J:149532]
Yue T; Xian K; Hurlock E; Xin M; Kernie SG; Parada LF; Lu QR. 2006. A critical role for dorsal progenitors in cortical myelination. J Neurosci 26(4):1275-80. [PubMed: 16436615] [MGI Ref ID J:105071]
Zelarayan LC; Vendrell V; Alvarez Y; Dominguez-Frutos E; Theil T; Alonso MT; Maconochie M; Schimmang T. 2007. Differential requirements for FGF3, FGF8 and FGF10 during inner ear development. Dev Biol 308(2):379-91. [PubMed: 17601531] [MGI Ref ID J:124118]
Zhang Z; Cerrato F; Xu H; Vitelli F; Morishima M; Vincentz J; Furuta Y; Ma L; Martin JF; Baldini A; Lindsay E. 2005. Tbx1 expression in pharyngeal epithelia is necessary for pharyngeal arch artery development. Development 132(23):5307-15. [PubMed: 16284121] [MGI Ref ID J:102843]
Zhou L; Bar I; Achouri Y; Campbell K; De Backer O; Hebert JM; Jones K; Kessaris N; de Rouvroit CL; O'Leary D; Richardson WD; Goffinet AM; Tissir F. 2008. Early forebrain wiring: genetic dissection using conditional Celsr3 mutant mice. Science 320(5878):946-9. [PubMed: 18487195] [MGI Ref ID J:134879]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX12
Colony Maintenance
Breeding & Husbandry When maintaining a live colony, these mice are bred as heterozygotes. Mating System Inbred x Heterozygote (Female x Male) 01-MAR-06 Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
|
Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $243.50 Female or Male Heterozygous for Foxg1tm1(cre)Skm
Pairs /Price (US dollars $) Pair Genotype $297.85 Heterozygous for Foxg1tm1(cre)Skm x Wild-type for Foxg1tm1(cre)Skm $297.85 Wild-type for Foxg1tm1(cre)Skm x Heterozygous for Foxg1tm1(cre)Skm
Additional Supply Details
| Pricing for International shipping destinations |
|
Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $316.60 Female or Male Heterozygous for Foxg1tm1(cre)Skm
Pairs /Price (US dollars $) Pair Genotype $387.30 Heterozygous for Foxg1tm1(cre)Skm x Wild-type for Foxg1tm1(cre)Skm $387.30 Wild-type for Foxg1tm1(cre)Skm x Heterozygous for Foxg1tm1(cre)Skm
Additional Supply Details
|
|
|
Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement. |
|---|---|
| Supply Notes |
|
Control Information
| Control | ||
|---|---|---|
| Wild-type from the colony | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
Purchasing Information
JAX® Mice Orders
Surgical Services
Contact Information
Orders & Technical Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form
Terms of Use
Terms of Use
General Terms and Conditions
For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.
Contact information
General inquiries
Contracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. In purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.