Strain Name:

STOCK Bdnftm3Jae/J

Stock Number:

004339

Order this mouse

Availability:

Repository- Live

Use Restrictions Apply, see Terms of Use
When bred to a strains expressing Cre recombinase under the control of a tetracycline-responsive promoter element and expressing a tetracycline-controlled activator protein in brain tissues or neuronal cells, for example, this mutant mouse strain may be useful in studies of hippocampal-dependent learning and long-term potentiation, and epilepsy respectively.

Description

Strain Information

Former Names STOCK Bdnftm2Jae/J    (Changed: 15-DEC-04 )
Type Mutant Stock; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Specieslaboratory mouse
GenerationN?F?+F14N1F12 (24-JAN-14)
Generation Definitions
 
Donating InvestigatorDr. Rudolf Jaenisch,   Whitehead Institute (MIT)

Description
These mice possess loxP sites on either side of the brain derived neurotrophic factor (Bdnf) coding region. Mice that are homozygous for this allele are viable and fertile.

When bred to a strain expressing Cre recombinase under the control of a tetracycline-responsive promoter element (see Stock No. 006224, 006234, 006244) and a strain expressing a tetracycline-controlled activator protein in brain tissues (see Stock No. 003763), this mutant mouse strain may be useful in studies of hippocampal-dependent learning and long-term potentiation.

When bred to a strain expressing Cre recombinase in neuronal cells (see Stock No. 003966 for example), this mutant mouse strain may be useful in studies of epilepsy.

Development
A targeting vector was designed to insert a single loxP site upstream of the coding region, and a loxP flanked hygromycin resistance (hygro) cassette downstream of the coding region of the brain derived neurotrophic factor (Bdnf) gene. This construct was electroporated into 129S4/SvJae derived J1 embryonic stem (ES) cells which were transiently transfected with a Cre-recombinase vector to remove the selection cassette. Correctly targeted ES cells were injected into BALB/c blastocysts.

Control Information

  Control
   None Available
 
  Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Bdnf
021055   B6.129S2(Cg)-Bdnftm1Krj/J
002266   B6.129S4-Bdnftm1Jae/J
002267   STOCK Bdnftm1Jae/J
View Strains carrying other alleles of Bdnf     (3 strains)

Additional Web Information

Introduction to Cre-lox technology

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Bulimia Nervosa, Susceptibility to, 1; BULN1   (BDNF)
Bulimia Nervosa, Susceptibility to, 2; BULN2   (BDNF)
Central Hypoventilation Syndrome, Congenital; CCHS   (BDNF)
Obsessive-Compulsive Disorder; OCD   (BDNF)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Bdnftm3Jae/Bdnftm3Jae

        involves: 129S4/SvJae
  • normal phenotype
  • no abnormal phenotype detected   (MGI Ref ID J:71969)

Bdnftm3Jae/Bdnftm3Jae

        involves: 129S4/SvJae   (conditional)
  • behavior/neurological phenotype
  • *normal* behavior/neurological phenotype
    • locomotor activity, anxiety, and novel object recognition responses in animals receiving injections of a lentivirus-cre (LV-cre) in the prelimbic cortex are similar to controls   (MGI Ref ID J:157538)
    • impaired cued conditioning behavior
      • animals receiving injections of a LV-cre in the prelimbic cortex display normal acquisition and expression of newly acquired fear, but when retested for fear to the cue (tone), show significantly decreased freezing responses relative to controls   (MGI Ref ID J:157538)

The following phenotype relates to a compound genotype created using this strain.
Contact JAX® Services jaxservices@jax.org for customized breeding options.

Bdnftm3Jae/Bdnftm3Jae Tg(Eno2tTA)5030Nes/0 Tg(tetO-cre)1Jaw/0

        involves: 129/Sv * C57BL/6 * ICR * SJL   (conditional)
  • behavior/neurological phenotype
  • abnormal contextual conditioning behavior
    • contextual learning is impaired in mutants when doxycycline treatment is stopped at 3 months of age compared to mutant littermates maintained on doxycycline   (MGI Ref ID J:91563)
    • contextual learning is virtually absent in mutants when no doxycycline treatment is given throughout development   (MGI Ref ID J:91563)
  • abnormal cued conditioning behavior
    • cued learning is normal in mutants when doxycycline treatment is stopped at 3 months of age but impaired when no doxycycline treatment is given throughout development   (MGI Ref ID J:91563)
  • hyperactivity
    • mutants bred without doxycycline treatment are hyperactive compared to mutants bred with doxycycline treatment   (MGI Ref ID J:91563)
    • hyperactivity is not seen when doxycycline treatment is stopped at 3 months of a   (MGI Ref ID J:91563)
  • impaired behavioral response to xenobiotic
    • no response is seen to the antidepressant desipramine in mutants when doxycycline treatment is stopped at 3 months of age   (MGI Ref ID J:91563)
  • nervous system phenotype
  • reduced long term potentiation
    • long term potentiation is impaired requiring a greater amplitude stimulus to evoke any response in mutants when doxycycline treatment is stopped at 3 months of age compared to mutant littermates maintained on doxycycline   (MGI Ref ID J:91563)

Bdnftm3Jae/Bdnftm3Jae Tg(Syn1-cre)671Jxm/0

        involves: 129/Sv * C57BL/6 * ICR   (conditional)
  • behavior/neurological phenotype
  • abnormal kindling response
    • an increased number of stimulations are required to initiate kindling behavior, however once initiated progression through subsequent classes of kindling is the same as in wild-type mice and no increase in the current required to induce the initial electrographic seizure is seen   (MGI Ref ID J:91467)
  • nervous system phenotype
  • abnormal kindling response
    • an increased number of stimulations are required to initiate kindling behavior, however once initiated progression through subsequent classes of kindling is the same as in wild-type mice and no increase in the current required to induce the initial electrographic seizure is seen   (MGI Ref ID J:91467)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Neurobiology Research
Cre-lox System
      loxP-flanked Sequences

Research Tools
Cre-lox System
      loxP-flanked Sequences
Diabetes and Obesity Research
      loxP

Bdnftm3Jae related

Apoptosis Research
Extracellular Modulators

Neurobiology Research
Hearing Defects
Neurotrophic Factor Defects

Sensorineural Research
Hearing Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Bdnftm3Jae
Allele Name targeted mutation 3, Rudolf Jaenisch
Allele Type Targeted (Conditional ready (e.g. floxed), No functional change)
Common Name(s) Bdnflox; Bdnf2; Bdnf2L; Bdnf2lox; Bdnftm2Jae;
Strain of Origin129S4/SvJae
ES Cell Line NameJ1
ES Cell Line Strain129S4/SvJae
Gene Symbol and Name Bdnf, brain derived neurotrophic factor
Chromosome 2
Gene Common Name(s) ANON2; BULN2;
Molecular Note A single loxP site was inserted 5' to the only coding exon, and a loxP-flanked hygromycin resistance cassette was inserted 3' to the exon. The hygromycin selection cassette was removed in ES cells by transient Cre expression leaving a single loxP site prior to the production of chimeric mice. [MGI Ref ID J:71969]

Genotyping

Genotyping Information

Genotyping Protocols

Bdnftm3Jae, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Rios M; Fan G; Fekete C; Kelly J; Bates B; Kuehn R; Lechan RM; Jaenisch R. 2001. Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity. Mol Endocrinol 15(10):1748-57. [PubMed: 11579207]  [MGI Ref ID J:71969]

Additional References

Okayasu I; Yamada Y; Maeda T; Yoshida N; Koga Y; Oi K. 2004. The involvement of brain-derived neurotrophic factor in the pattern generator of mastication. Brain Res 1016(1):40-7. [PubMed: 15234250]  [MGI Ref ID J:91229]

Bdnftm3Jae related

Akbarian S; Rios M; Liu RJ; Gold SJ; Fong HF; Zeiler S; Coppola V; Tessarollo L; Jones KR; Nestler EJ; Aghajanian GK; Jaenisch R. 2002. Brain-derived neurotrophic factor is essential for opiate-induced plasticity of noradrenergic neurons. J Neurosci 22(10):4153-62. [PubMed: 12019333]  [MGI Ref ID J:76683]

Baydyuk M; Xie Y; Tessarollo L; Xu B. 2013. Midbrain-derived neurotrophins support survival of immature striatal projection neurons. J Neurosci 33(8):3363-9. [PubMed: 23426664]  [MGI Ref ID J:194255]

Berton O; McClung CA; Dileone RJ; Krishnan V; Renthal W; Russo SJ; Graham D; Tsankova NM; Bolanos CA; Rios M; Monteggia LM; Self DW; Nestler EJ. 2006. Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science 311(5762):864-8. [PubMed: 16469931]  [MGI Ref ID J:105490]

Betley JN; Wright CV; Kawaguchi Y; Erdelyi F; Szabo G; Jessell TM; Kaltschmidt JA. 2009. Stringent specificity in the construction of a GABAergic presynaptic inhibitory circuit. Cell 139(1):161-74. [PubMed: 19804761]  [MGI Ref ID J:157313]

Bloodgood BL; Sharma N; Browne HA; Trepman AZ; Greenberg ME. 2013. The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition. Nature 503(7474):121-5. [PubMed: 24201284]  [MGI Ref ID J:207770]

Camerino C; Zayzafoon M; Rymaszewski M; Heiny J; Rios M; Hauschka PV. 2012. Central depletion of brain-derived neurotrophic factor in mice results in high bone mass and metabolic phenotype. Endocrinology 153(11):5394-405. [PubMed: 23011922]  [MGI Ref ID J:190953]

Chan JP; Unger TJ; Byrnes J; Rios M. 2006. Examination of behavioral deficits triggered by targeting Bdnf in fetal or postnatal brains of mice. Neuroscience 142(1):49-58. [PubMed: 16844311]  [MGI Ref ID J:113166]

Chang Q; Khare G; Dani V; Nelson S; Jaenisch R. 2006. The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression. Neuron 49(3):341-8. [PubMed: 16446138]  [MGI Ref ID J:106973]

Choi DC; Maguschak KA; Ye K; Jang SW; Myers KM; Ressler KJ. 2010. Prelimbic cortical BDNF is required for memory of learned fear but not extinction or innate fear. Proc Natl Acad Sci U S A 107(6):2675-80. [PubMed: 20133801]  [MGI Ref ID J:157538]

Clow C; Jasmin BJ. 2010. Brain-derived neurotrophic factor regulates satellite cell differentiation and skeltal muscle regeneration. Mol Biol Cell 21(13):2182-90. [PubMed: 20427568]  [MGI Ref ID J:165062]

Cordeira JW; Felsted JA; Teillon S; Daftary S; Panessiti M; Wirth J; Sena-Esteves M; Rios M. 2014. Hypothalamic dysfunction of the thrombospondin receptor alpha2delta-1 underlies the overeating and obesity triggered by brain-derived neurotrophic factor deficiency. J Neurosci 34(2):554-65. [PubMed: 24403154]  [MGI Ref ID J:205578]

Cordeira JW; Frank L; Sena-Esteves M; Pothos EN; Rios M. 2010. Brain-derived neurotrophic factor regulates hedonic feeding by acting on the mesolimbic dopamine system. J Neurosci 30(7):2533-41. [PubMed: 20164338]  [MGI Ref ID J:157836]

Daftary SS; Calderon G; Rios M. 2012. Essential role of brain-derived neurotrophic factor in the regulation of serotonin transmission in the basolateral amygdala. Neuroscience 224:125-34. [PubMed: 22917617]  [MGI Ref ID J:192483]

Ferrini F; Trang T; Mattioli TA; Laffray S; Del'Guidice T; Lorenzo LE; Castonguay A; Doyon N; Zhang W; Godin AG; Mohr D; Beggs S; Vandal K; Beaulieu JM; Cahill CM; Salter MW; De Koninck Y. 2013. Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl(-) homeostasis. Nat Neurosci 16(2):183-92. [PubMed: 23292683]  [MGI Ref ID J:197479]

Gao X; Smith GM; Chen J. 2009. Impaired dendritic development and synaptic formation of postnatal-born dentate gyrus granular neurons in the absence of brain-derived neurotrophic factor signaling. Exp Neurol 215(1):178-90. [PubMed: 19014937]  [MGI Ref ID J:144750]

Gomez-Casati ME; Murtie JC; Rio C; Stankovic K; Liberman MC; Corfas G. 2010. Nonneuronal cells regulate synapse formation in the vestibular sensory epithelium via erbB-dependent BDNF expression. Proc Natl Acad Sci U S A 107(39):17005-10. [PubMed: 20837532]  [MGI Ref ID J:164570]

Gourley SL; Howell JL; Rios M; DiLeone RJ; Taylor JR. 2009. Prelimbic cortex bdnf knock-down reduces instrumental responding in extinction. Learn Mem 16(12):756-60. [PubMed: 19926781]  [MGI Ref ID J:166308]

Gourley SL; Swanson AM; Jacobs AM; Howell JL; Mo M; Dileone RJ; Koleske AJ; Taylor JR. 2012. Action control is mediated by prefrontal BDNF and glucocorticoid receptor binding. Proc Natl Acad Sci U S A 109(50):20714-9. [PubMed: 23185000]  [MGI Ref ID J:193130]

Graham DL; Edwards S; Bachtell RK; Dileone RJ; Rios M; Self DW. 2007. Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapse. Nat Neurosci 10(8):1029-37. [PubMed: 17618281]  [MGI Ref ID J:124163]

Hashimoto T; Bergen SE; Nguyen QL; Xu B; Monteggia LM; Pierri JN; Sun Z; Sampson AR; Lewis DA. 2005. Relationship of brain-derived neurotrophic factor and its receptor TrkB to altered inhibitory prefrontal circuitry in schizophrenia. J Neurosci 25(2):372-83. [PubMed: 15647480]  [MGI Ref ID J:97675]

He XP; Kotloski R; Nef S; Luikart BW; Parada LF; McNamara JO. 2004. Conditional deletion of TrkB but not BDNF prevents epileptogenesis in the kindling model. Neuron 43(1):31-42. [PubMed: 15233915]  [MGI Ref ID J:91467]

Heldt SA; Ressler KJ. 2009. The Use of Lentiviral Vectors and Cre/loxP to Investigate the Function of Genes in Complex Behaviors. Front Mol Neurosci 2:22. [PubMed: 20011219]  [MGI Ref ID J:210657]

Heldt SA; Stanek L; Chhatwal JP; Ressler KJ. 2007. Hippocampus-specific deletion of BDNF in adult mice impairs spatial memory and extinction of aversive memories. Mol Psychiatry 12(7):656-70. [PubMed: 17264839]  [MGI Ref ID J:137002]

Hill JJ; Kolluri N; Hashimoto T; Wu Q; Sampson AR; Monteggia LM; Lewis DA. 2005. Analysis of pyramidal neuron morphology in an inducible knockout of brain-derived neurotrophic factor. Biol Psychiatry 57(8):932-4. [PubMed: 15820715]  [MGI Ref ID J:102119]

Huang YZ; Pan E; Xiong ZQ; McNamara JO. 2008. Zinc-mediated transactivation of TrkB potentiates the hippocampal mossy fiber-CA3 pyramid synapse. Neuron 57(4):546-58. [PubMed: 18304484]  [MGI Ref ID J:135687]

Jang SW; Liu X; Pradoldej S; Tosini G; Chang Q; Iuvone PM; Ye K. 2010. N-acetylserotonin activates TrkB receptor in a circadian rhythm. Proc Natl Acad Sci U S A 107(8):3876-81. [PubMed: 20133677]  [MGI Ref ID J:157560]

Jang SW; Liu X; Yepes M; Shepherd KR; Miller GW; Liu Y; Wilson WD; Xiao G; Blanchi B; Sun YE; Ye K. 2010. A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. Proc Natl Acad Sci U S A 107(6):2687-92. [PubMed: 20133810]  [MGI Ref ID J:157536]

Klein AB; Santini MA; Aznar S; Knudsen GM; Rios M. 2010. Changes in 5-HT2A-mediated behavior and 5-HT2A- and 5-HT1A receptor binding and expression in conditional brain-derived neurotrophic factor knock-out mice. Neuroscience 169(3):1007-16. [PubMed: 20576498]  [MGI Ref ID J:165221]

Koo JW; Mazei-Robison MS; Chaudhury D; Juarez B; LaPlant Q; Ferguson D; Feng J; Sun H; Scobie KN; Damez-Werno D; Crumiller M; Ohnishi YN; Ohnishi YH; Mouzon E; Dietz DM; Lobo MK; Neve RL; Russo SJ; Han MH; Nestler EJ. 2012. BDNF is a negative modulator of morphine action. Science 338(6103):124-8. [PubMed: 23042896]  [MGI Ref ID J:188256]

Lyckman AW; Fan G; Rios M; Jaenisch R; Sur M. 2005. Normal eye-specific patterning of retinal inputs to murine subcortical visual nuclei in the absence of brain-derived neurotrophic factor. Vis Neurosci 22(1):27-36. [PubMed: 15842738]  [MGI Ref ID J:105280]

Ma L; Lopez GF; Krimm RF. 2009. Epithelial-derived brain-derived neurotrophic factor is required for gustatory neuron targeting during a critical developmental period. J Neurosci 29(11):3354-64. [PubMed: 19295142]  [MGI Ref ID J:147048]

Monteggia LM; Barrot M; Powell CM; Berton O; Galanis V; Gemelli T; Meuth S; Nagy A; Greene RW; Nestler EJ. 2004. Essential role of brain-derived neurotrophic factor in adult hippocampal function. Proc Natl Acad Sci U S A 101(29):10827-32. [PubMed: 15249684]  [MGI Ref ID J:91563]

Norata GD; Venu VK; Callegari E; Paloschi V; Catapano AL. 2012. Effect of Tie-2 conditional deletion of BDNF on atherosclerosis in the ApoE null mutant mouse. Biochim Biophys Acta 1822(6):927-35. [PubMed: 22386878]  [MGI Ref ID J:184993]

Nosyreva E; Szabla K; Autry AE; Ryazanov AG; Monteggia LM; Kavalali ET. 2013. Acute suppression of spontaneous neurotransmission drives synaptic potentiation. J Neurosci 33(16):6990-7002. [PubMed: 23595756]  [MGI Ref ID J:196965]

Oo TF; Marchionini DM; Yarygina O; O'Leary PD; Hughes RA; Kholodilov N; Burke RE. 2009. Brain-derived neurotrophic factor regulates early postnatal developmental cell death of dopamine neurons of the substantia nigra in vivo. Mol Cell Neurosci 41(4):440-7. [PubMed: 19409492]  [MGI Ref ID J:154254]

Parkhurst CN; Yang G; Ninan I; Savas JN; Yates JR 3rd; Lafaille JJ; Hempstead BL; Littman DR; Gan WB. 2013. Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. Cell 155(7):1596-609. [PubMed: 24360280]  [MGI Ref ID J:205483]

Rantamaki T; Vesa L; Antila H; Di Lieto A; Tammela P; Schmitt A; Lesch KP; Rios M; Castren E. 2011. Antidepressant drugs transactivate TrkB neurotrophin receptors in the adult rodent brain independently of BDNF and monoamine transporter blockade. PLoS One 6(6):e20567. [PubMed: 21666748]  [MGI Ref ID J:174143]

Sridurongrit S; Larsson J; Schwartz R; Ruiz-Lozano P; Kaartinen V. 2008. Signaling via the Tgf-beta type I receptor Alk5 in heart development. Dev Biol 322(1):208-18. [PubMed: 18718461]  [MGI Ref ID J:142286]

Walsh JJ; Friedman AK; Sun H; Heller EA; Ku SM; Juarez B; Burnham VL; Mazei-Robison MS; Ferguson D; Golden SA; Koo JW; Chaudhury D; Christoffel DJ; Pomeranz L; Friedman JM; Russo SJ; Nestler EJ; Han MH. 2014. Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway. Nat Neurosci 17(1):27-9. [PubMed: 24270188]  [MGI Ref ID J:207834]

Zhao J; Seereeram A; Nassar MA; Levato A; Pezet S; Hathaway G; Morenilla-Palao C; Stirling C; Fitzgerald M; McMahon SB; Rios M; Wood JN. 2006. Nociceptor-derived brain-derived neurotrophic factor regulates acute and inflammatory but not neuropathic pain. Mol Cell Neurosci 31(3):539-48. [PubMed: 16413788]  [MGI Ref ID J:106864]

Zuccotti A; Kuhn S; Johnson SL; Franz C; Singer W; Hecker D; Geisler HS; Kopschall I; Rohbock K; Gutsche K; Dlugaiczyk J; Schick B; Marcotti W; Ruttiger L; Schimmang T; Knipper M. 2012. Lack of Brain-Derived Neurotrophic Factor Hampers Inner Hair Cell Synapse Physiology, But Protects against Noise-Induced Hearing Loss. J Neurosci 32(25):8545-8553. [PubMed: 22723694]  [MGI Ref ID J:185663]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX12

Colony Maintenance

Breeding & HusbandryThis strain originated on a mixed C;129S4 background. The Donating Investigator maintained it as as a homozygote on a mixed B6, 129S4, BALB/c background. Coat color expected from breeding:Albino
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $232.00Female or MaleHomozygous for Bdnftm3Jae  
Price per Pair (US dollars $)Pair Genotype
$464.00Homozygous for Bdnftm3Jae x Homozygous for Bdnftm3Jae  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $301.60Female or MaleHomozygous for Bdnftm3Jae  
Price per Pair (US dollars $)Pair Genotype
$603.20Homozygous for Bdnftm3Jae x Homozygous for Bdnftm3Jae  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

  Control
   None Available
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


(6.8)