Strain Name:

NOD.Cg-Rag1tm1Mom Tg(TcrbAI4)1Dvs/DvsJ

Stock Number:

004348

Availability:

Repository-Cryopreserved

Use Restrictions Apply, see Purchasing Information

Description

Strain Information

Former Names NOD.Cg-Tg(TcrbAI4)1Dvs Rag1tm1Mom/DvsJ    (Changed: 15-DEC-04 )
Type Congenic; Mutant Strain; Targeted Mutation; Transgenic;
Specieslaboratory mouse
H2 Haplotypeg7
GenerationF3p (08-JAN-04)
 
Donating Investigator David Serreze,   The Jackson Laboratory

Appearance
albino, pink eyed
Related Genotype: A/A Tyrc/Tyrc

Description
The rearranged Tcrb transgene expressed in these mice is derived from the pancreatic beta cell-reactive CD8 T lymphocyte clone AI4. The presence of the nonfunctional Rag1tm1Mom allele renders mice incapable of rearranging endogenous T cell receptor genes. When crossed with strain NOD.Cg-Tg(TcraAI4)1Dvs-Rag1tm1Mom/DvsJ (004347), the resulting animals that carry both the alpha and beta AI4 TCR transgenes exhibit an accelerated development of insulin-dependent diabetes mellitus (IDDM). Additionally, transgenic animals bearing both TCR transgenes offer a source of CTL precursors useful in examining the diversity of beta cell peptides recognized by the autoreactive CD8+ T lymphocytes contributing to the earliest phase of IDDM development. Homozygous mice are viable and fertile.

Development
A transgenic construct containing a Tcrb-V2/Tcrb-D/Tcrb-J cDNA segment was injected into NOD/Lt zygotes. An outcross-intercross strategy was employed to introduce an inactivated Rag1 allele from an N11 congenic stock, NOD.129S7(B6)-Rag1tm1Mom/J mice (strain 003729).

Control Information

  Control
   003729 NOD.129S7(B6)-Rag1tm1Mom/J
 
  Considerations for Choosing Controls

Related Strains

View Strains carrying   Rag1tm1Mom     (16 strains)

View Strains carrying   Tg(TcrbAI4)1Dvs     (4 strains)

Strains carrying other alleles of Rag1
007790   B6;129P2-Rag1/Rag2tm1Mnz/J
002194   B6;CBA-Tg(CD3E)26Cpt/J
002506   STOCK Tg(CD3E)26Cpt-Rag1tm1Mom/J
View Strains carrying other alleles of Rag1     (3 strains)

View Strains carrying other alleles of Tcrb     (32 strains)

Additional Web Information

Congenic Nomenclature

Phenotype

Phenotype Information

Research Applications

This mouse can be used to support research in many areas including:

Diabetes and Obesity Research
Type 1 Diabetes (IDDM) Analysis Strains (NOD Congenics with Mutations Affecting Immunocompetence)
Type 1 Diabetes (IDDM) Analysis Strains (NOD Transgenics)

Research Tools
Immunology and Inflammation Research (T Cell Receptor Transgenics)

Tcrb related

Hematological Research
Immunological Defects

Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunodeficiency
Inflammation
T Cell Receptor Signaling Defects

Rag1tm1Mom related

Cancer Research
Toxicology (B and T cell deficiency) (xenograft/transplant host)

Hematological Research
Immunological Defects (B and T cell deficiency)

Immunology and Inflammation Research
Immunodeficiency (B and T cell deficiency)
Inflammation (B and T cell deficiency)
T Cell Receptor Signaling Defects (B and T cell deficiency)

Internal/Organ Research
Lymphoid Tissue Defects (B and T cell deficiency)

Research Tools
Cancer Research (B and T cell deficiency) (xenograft/transplant host)
Toxicology Research (xenograft/transplant host)

Genes & Alleles

Gene & Allele Information

Allele Symbol Rag1tm1Mom
Allele Name targeted mutation 1, Peter Mombaerts
Common Name(s) RAG-1-; RAG1null; Rag-; Rag-1KO; Rag1-;
Mutation Made By Peter Mombaerts,   Max Planck Institute of Biophysics
Strain of Origin129S7/SvEvBrd-Hprt1<+>
ES Cell Line NameAB1
ES Cell Line Strain129S7/SvEvBrd-Hprt1<+>
Gene Symbol and Name Rag1, recombination activating gene 1
Chromosome 2
Gene Common Name(s) MGC43321; RNF74; Rag-1;
Molecular Note A 1356 bp genomic fragment of the Rag1 gene, encoding the nuclear localization signal and the zinc-finger motif, was replaced by a neomycin cassette. A mutant transcript expressed from this allele was detected by Northern blot in bone marrow derived cell lines from homozygous mice. [MGI Ref ID J:1934] [MGI Ref ID J:96036]
 
Allele Symbol Tg(TcrbAI4)1Dvs
Allele Name transgene insertion 1, David V Serreze
Common Name(s) AI4bTg;
Mutation Made By David Serreze,   The Jackson Laboratory
Strain of OriginNOD/ShiLt
Expressed Gene Tcrb, T-cell receptor beta chain, mouse, laboratory
General Note In conjunction with Rag1tm1Mom
    transgenic mice carrying both the alpha and beta AI4 TCR transgenes exhibit an accelerated development of insulin-dependent diabetes mellitus (IDDM).
    homozygous mice are viable and fertile
Molecular Note The rearranged Tcrb transgene expressed in these mice is derived from the pancreatic beta cell-reactive CD8 T lymphocyte clone AI4. The transgenic construct contains a Tcrb-V2/Tcrb-D/Tcrb-J cDNA segment. [MGI Ref ID J:93553]

Genotyping

Genotyping Information

Genotyping Protocols

Rag1tm1Mom, STD PCR, vers. 1
Rag1tm1Mom, STD PCR, vers. 1
Tg(TcrbAI4)1Dvs, STD PCR, vers. 1

Helpful Links

Optimizing PCR Protocols

References

References

Selected Reference(s)

DiLorenzo TP; Lieberman SM; Takaki T; Honda S; Chapman HD; Santamaria P; Serreze DV; Nathenson SG. 2002. During the early prediabetic period in NOD mice, the pathogenic CD8(+) T-cell population comprises multiple antigenic specificities. Clin Immunol 105(3):332-41. [PubMed: 12498815]  [MGI Ref ID J:94192]

Additional References

Graser RT; DiLorenzo TP; Wang F; Christianson GJ; Chapman HD; Roopenian DC; Nathenson SG; Serreze DV. 2000. Identification of a CD8 T cell that can independently mediate autoimmune diabetes development in the complete absence of CD4 T cell helper functions. J Immunol 164(7):3913-8. [PubMed: 10725754]  [MGI Ref ID J:93553]

Rag1tm1Mom related

Ait-Azzouzene D; Verkoczy L; Peters J; Gavin A; Skog P; Vela JL; Nemazee D. 2005. An immunoglobulin C{kappa}-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system. J Exp Med 201(5):817-28. [PubMed: 15738053]  [MGI Ref ID J:96759]

Alugupalli KR; Gerstein RM; Chen J; Szomolanyi-Tsuda E; Woodland RT; Leong JM. 2003. The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes. J Immunol 170(7):3819-27. [PubMed: 12646649]  [MGI Ref ID J:125443]

Alugupalli KR; Leong JM; Woodland RT; Muramatsu M; Honjo T; Gerstein RM. 2004. B1b lymphocytes confer T cell-independent long-lasting immunity. Immunity 21(3):379-90. [PubMed: 15357949]  [MGI Ref ID J:93752]

Anderson MG; Nair KS; Amonoo LA; Mehalow A; Trantow CM; Masli S; John SW. 2008. GpnmbR150X allele must be present in bone marrow derived cells to mediate DBA/2J glaucoma. BMC Genet 9:30. [PubMed: 18402690]  [MGI Ref ID J:134670]

Anginot A; Dacquin R; Mazzorana M; Jurdic P. 2007. Lymphocytes and the Dap12 adaptor are key regulators of osteoclast activation associated with gonadal failure. PLoS ONE 2(7):e585. [PubMed: 17611620]  [MGI Ref ID J:129304]

Antony PA; Piccirillo CA; Akpinarli A; Finkelstein SE; Speiss PJ; Surman DR; Palmer DC; Chan CC; Klebanoff CA; Overwijk WW; Rosenberg SA; Restifo NP. 2005. CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells. J Immunol 174(5):2591-601. [PubMed: 15728465]  [MGI Ref ID J:129825]

Aurora AB; Baluk P; Zhang D; Sidhu SS; Dolganov GM; Basbaum C; McDonald DM; Killeen N. 2005. Immune complex-dependent remodeling of the airway vasculature in response to a chronic bacterial infection. J Immunol 175(10):6319-26. [PubMed: 16272283]  [MGI Ref ID J:119344]

Baccala R; Witherden D; Gonzalez-Quintial R; Dummer W; Surh CD; Havran WL; Theofilopoulos AN. 2005. Gamma delta T cell homeostasis is controlled by IL-7 and IL-15 together with subset-specific factors. J Immunol 174(8):4606-12. [PubMed: 15814683]  [MGI Ref ID J:98166]

Backhed F; Ding H; Wang T; Hooper LV; Koh GY; Nagy A; Semenkovich CF; Gordon JI. 2004. The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A 101(44):15718-23. [PubMed: 15505215]  [MGI Ref ID J:93455]

Banuelos SJ; Shultz LD; Greiner DL; Burzenski LM; Gott B; Lyons BL; Rossini AA; Appel MC. 2004. Rejection of human islets and human HLA-A2.1 transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD-scid and NOD-Rag1(null)Prf1(null) mice. Clin Immunol 112(3):273-83. [PubMed: 15308121]  [MGI Ref ID J:91764]

Barjaktarevic I; Rahman A; Radoja S; Bogunovic B; Vollmer A; Vukmanovic S; Maric M. 2006. Inhibitory role of IFN-gamma-inducible lysosomal thiol reductase in T cell activation. J Immunol 177(7):4369-75. [PubMed: 16982871]  [MGI Ref ID J:139329]

Beilke JN; Kuhl NR; Van Kaer L; Gill RG. 2005. NK cells promote islet allograft tolerance via a perforin-dependent mechanism. Nat Med 11(10):1059-65. [PubMed: 16155578]  [MGI Ref ID J:101693]

Belkaid Y; Von Stebut E; Mendez S; Lira R; Caler E; Bertholet S; Udey MC; Sacks D. 2002. CD8+ T cells are required for primary immunity in C57BL/6 mice following low-dose, intradermal challenge with Leishmania major. J Immunol 168(8):3992-4000. [PubMed: 11937556]  [MGI Ref ID J:125458]

Bergstrom KS; Guttman JA; Rumi M; Ma C; Bouzari S; Khan MA; Gibson DL; Vogl AW; Vallance BA. 2008. Modulation of intestinal goblet cell function during infection by an attaching and effacing bacterial pathogen. Infect Immun 76(2):796-811. [PubMed: 17984203]  [MGI Ref ID J:130255]

Bessler M; Rosti V; Peng Y; Cattoretti G; Notaro R; Ohsako S; Elkon KB; Luzzatto L. 2002. Glycosylphosphatidylinositol-linked proteins are required for maintenance of a normal peripheral lymphoid compartment but not for lymphocyte development. Eur J Immunol 32(9):2607-16. [PubMed: 12207345]  [MGI Ref ID J:78996]

Bettelli E; Pagany M; Weiner HL; Linington C; Sobel RA; Kuchroo VK. 2003. Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis. J Exp Med 197(9):1073-81. [PubMed: 12732654]  [MGI Ref ID J:83278]

Binder GK; Griffin DE. 2001. Interferon-gamma-mediated site-specific clearance of alphavirus from CNS neurons. Science 293(5528):303-6. [PubMed: 11452126]  [MGI Ref ID J:125465]

Block MS; Mendez-Fernandez YV; Van Keulen VP; Hansen MJ; Allen KS; Taboas AL; Rodriguez M; Pease LR. 2005. Inability of bm14 mice to respond to Theiler's murine encephalomyelitis virus is caused by defective antigen presentation, not repertoire selection. J Immunol 174(5):2756-62. [PubMed: 15728484]  [MGI Ref ID J:97717]

Borghesi L; Hsu LY; Miller JP; Anderson M; Herzenberg L; Herzenberg L; Schlissel MS; Allman D; Gerstein RM. 2004. B lineage-specific regulation of V(D)J recombinase activity is established in common lymphoid progenitors. J Exp Med 199(4):491-502. [PubMed: 14769852]  [MGI Ref ID J:119401]

Bour-Jordan H; Salomon BL; Thompson HL; Szot GL; Bernhard MR; Bluestone JA. 2004. Costimulation controls diabetes by altering the balance of pathogenic and regulatory T cells. J Clin Invest 114(7):979-87. [PubMed: 15467837]  [MGI Ref ID J:93421]

Broxmeyer HE; Sehra S; Cooper S; Toney LM; Kusam S; Aloor JJ; Marchal CC; Dinauer MC; Dent AL. 2007. Aberrant regulation of hematopoiesis by T cells in BAZF-deficient mice. Mol Cell Biol 27(15):5275-85. [PubMed: 17526724]  [MGI Ref ID J:123621]

Burich A; Hershberg R; Waggie K; Zeng W; Brabb T; Westrich G; Viney JL; Maggio-Price L. 2001. Helicobacter-induced inflammatory bowel disease in IL-10- and T cell-deficient mice. Am J Physiol Gastrointest Liver Physiol 281(3):G764-78. [PubMed: 11518689]  [MGI Ref ID J:108283]

Cao Y; Luo JL; Karin M. 2007. IkappaB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells. Proc Natl Acad Sci U S A 104(40):15852-7. [PubMed: 17890319]  [MGI Ref ID J:125555]

Carrio R; Rolle CE; Malek TR. 2007. Non-redundant role for IL-7R signaling for the survival of CD8(+) memory T cells. Eur J Immunol 37(11):3078-88. [PubMed: 17935075]  [MGI Ref ID J:126334]

Cernetich A; Garver LS; Jedlicka AE; Klein PW; Kumar N; Scott AL; Klein SL. 2006. Involvement of gonadal steroids and gamma interferon in sex differences in response to blood-stage malaria infection. Infect Immun 74(6):3190-203. [PubMed: 16714546]  [MGI Ref ID J:109239]

Chao TK; Rifai A; Ka SM; Yang SM; Shui HA; Lin YF; Sytwu HK; Lee WH; Kung JT; Chen A. 2006. The endogenous immune response modulates the course of IgA-immune complex mediated nephropathy. Kidney Int 70(2):283-97. [PubMed: 16738538]  [MGI Ref ID J:136494]

Chatterjee G; Carrithers LM; Carrithers MD. 2008. Epithelial V-like antigen regulates permeability of the blood-CSF barrier. Biochem Biophys Res Commun 372(3):412-7. [PubMed: 18498762]  [MGI Ref ID J:137884]

Chen BP; Kuziel WA; Lane TE. 2001. Lack of CCR2 results in increased mortality and impaired leukocyte activation and trafficking following infection of the central nervous system with a neurotropic coronavirus. J Immunol 167(8):4585-92. [PubMed: 11591787]  [MGI Ref ID J:106738]

Chen M; Lichtler AC; Sheu TJ; Xie C; Zhang X; O'Keefe RJ; Chen D. 2007. Generation of a transgenic mouse model with chondrocyte-specific and tamoxifen-inducible expression of Cre recombinase. Genesis 45(1):44-50. [PubMed: 17211877]  [MGI Ref ID J:117868]

Chen R; Fairley JA; Zhao ML; Giudice GJ; Zillikens D; Diaz LA; Liu Z. 2002. Macrophages, but not T and B lymphocytes, are critical for subepidermal blister formation in experimental bullous pemphigoid: macrophage-mediated neutrophil infiltration depends on mast cell activation. J Immunol 169(7):3987-92. [PubMed: 12244200]  [MGI Ref ID J:120403]

Christopher K; Liang Y; Mueller TF; DeFina R; He H; Haley KJ; Exley MA; Finn PW; Perkins DL. 2004. Analysis of the major histocompatibility complex in graft rejection revisited by gene expression profiles. Transplantation 78(6):788-98. [PubMed: 15385796]  [MGI Ref ID J:98356]

Corre I; Gomez M; Vielkind S; Cantrell DA. 2001. Analysis of thymocyte development reveals that the GTPase RhoA is a positive regulator of T cell receptor responses in vivo. J Exp Med 194(7):903-14. [PubMed: 11581313]  [MGI Ref ID J:134058]

Crompton T; Gilmour KC; Owen MJ. 1996. The MAP kinase pathway controls differentiation from double-negative to double-positive thymocyte. Cell 86(2):243-51. [PubMed: 8706129]  [MGI Ref ID J:34462]

Curotto de Lafaille MA; Kutchukhidze N; Shen S; Ding Y; Yee H; Lafaille JJ. 2008. Adaptive Foxp3+ regulatory T cell-dependent and -independent control of allergic inflammation. Immunity 29(1):114-26. [PubMed: 18617425]  [MGI Ref ID J:137881]

Curotto de Lafaille MA; Muriglan S; Sunshine MJ; Lei Y; Kutchukhidze N; Furtado GC; Wensky AK; Olivares-Villagomez D; Lafaille JJ. 2001. Hyper immunoglobulin E response in mice with monoclonal populations of B and T lymphocytes. J Exp Med 194(9):1349-59. [PubMed: 11696599]  [MGI Ref ID J:100072]

Cushman J; Lo J; Huang Z; Wasserfall C; Petitto JM. 2003. Neurobehavioral changes resulting from recombinase activation gene 1 deletion. Clin Diagn Lab Immunol 10(1):13-8. [PubMed: 12522033]  [MGI Ref ID J:102410]

Das G; Augustine MM; Das J; Bottomly K; Ray P; Ray A. 2003. An important regulatory role for CD4+CD8 alpha alpha T cells in the intestinal epithelial layer in the prevention of inflammatory bowel disease. Proc Natl Acad Sci U S A 100(9):5324-9. [PubMed: 12695566]  [MGI Ref ID J:83283]

De Jersey J; Carmignac D; Le Tissier P; Barthlott T; Robinson I; Stockinger B. 2004. Factors affecting the susceptibility of the mouse pituitary gland to CD8 T-cell-mediated autoimmunity. Immunology 111(3):254-61. [PubMed: 15009425]  [MGI Ref ID J:131885]

Debard N; Sierro F; Browning J; Kraehenbuhl JP. 2001. Effect of mature lymphocytes and lymphotoxin on the development of the follicle-associated epithelium and M cells in mouse Peyer's patches. Gastroenterology 120(5):1173-82. [PubMed: 11266381]  [MGI Ref ID J:68429]

Dimayuga PC; Li H; Chyu KY; Fredrikson GN; Nilsson J; Fishbein MC; Shah PK; Cercek B. 2005. T cell modulation of intimal thickening after vascular injury: the bimodal role of IFN-gamma in immune deficiency. Arterioscler Thromb Vasc Biol 25(12):2528-34. [PubMed: 16224059]  [MGI Ref ID J:116822]

Dokun AO; Chu DT; Yang L; Bendelac AS; Yokoyama WM. 2001. Analysis of in situ NK cell responses during viral infection. J Immunol 167(9):5286-93. [PubMed: 11673544]  [MGI Ref ID J:72673]

Ehl S; Hombach J; Aichele P; Rulicke T; Odermatt B; Hengartner H; Zinkernagel R; Pircher H. 1998. Viral and bacterial infections interfere with peripheral tolerance induction and activate CD8+ T cells to cause immunopathology. J Exp Med 187(5):763-74. [PubMed: 9480986]  [MGI Ref ID J:132027]

El Andaloussi A; Graves S; Meng F; Mandal M; Mashayekhi M; Aifantis I. 2006. Hedgehog signaling controls thymocyte progenitor homeostasis and differentiation in the thymus. Nat Immunol 7(4):418-26. [PubMed: 16518394]  [MGI Ref ID J:112555]

Engwerda CR; Ato M; Stager S; Alexander CE; Stanley AC; Kaye PM. 2004. Distinct roles for lymphotoxin-alpha and tumor necrosis factor in the control of Leishmania donovani infection. Am J Pathol 165(6):2123-33. [PubMed: 15579454]  [MGI Ref ID J:94946]

Fathers KE; Stone CM; Minhas K; Marriott JJ; Greenwood JD; Dumont DJ; Coomber BL. 2005. Heterogeneity of Tie2 expression in tumor microcirculation: influence of cancer type, implantation site, and response to therapy. Am J Pathol 167(6):1753-62. [PubMed: 16314485]  [MGI Ref ID J:107320]

Fleming SD; Egan RP; Chai C; Girardi G; Holers VM; Salmon J; Monestier M; Tsokos GC. 2004. Anti-phospholipid antibodies restore mesenteric ischemia/reperfusion-induced injury in complement receptor 2/complement receptor 1-deficient mice. J Immunol 173(11):7055-61. [PubMed: 15557203]  [MGI Ref ID J:94355]

Fontenot JD; Rasmussen JP; Williams LM; Dooley JL; Farr AG; Rudensky AY. 2005. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 22(3):329-41. [PubMed: 15780990]  [MGI Ref ID J:97029]

Forlow SB; White EJ; Thomas KL; Bagby GJ; Foley PL; Ley K. 2002. T cell requirement for development of chronic ulcerative dermatitis in e- and p-selectin-deficient mice. J Immunol 169(9):4797-804. [PubMed: 12391189]  [MGI Ref ID J:79774]

French AR; Sjolin H; Kim S; Koka R; Yang L; Young DA; Cerboni C; Tomasello E; Ma A; Vivier E; Karre K; Yokoyama WM. 2006. DAP12 signaling directly augments proproliferative cytokine stimulation of NK cells during viral infections. J Immunol 177(8):4981-90. [PubMed: 17015680]  [MGI Ref ID J:139300]

Fu YX; Huang G; Matsumoto M; Molina H; Chaplin DD. 1997. Independent signals regulate development of primary and secondary follicle structure in spleen and mesenteric lymph node. Proc Natl Acad Sci U S A 94(11):5739-43. [PubMed: 9159143]  [MGI Ref ID J:78647]

Fu YX; Huang G; Wang Y; Chaplin DD. 1998. B lymphocytes induce the formation of follicular dendritic cell clusters in a lymphotoxin alpha-dependent fashion. J Exp Med 187(7):1009-18. [PubMed: 9529317]  [MGI Ref ID J:118756]

Fukumura D; Gohongi T; Kadambi A; Izumi Y; Ang J; Yun CO; Buerk DG; Huang PL; Jain RK. 2001. Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability. Proc Natl Acad Sci U S A 98(5):2604-9. [PubMed: 11226286]  [MGI Ref ID J:67870]

Galkina E; Kadl A; Sanders J; Varughese D; Sarembock IJ; Ley K. 2006. Lymphocyte recruitment into the aortic wall before and during development of atherosclerosis is partially L-selectin dependent. J Exp Med 203(5):1273-82. [PubMed: 16682495]  [MGI Ref ID J:124135]

Gavin MA; Clarke SR; Negrou E; Gallegos A; Rudensky A. 2002. Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivo. Nat Immunol 3(1):33-41. [PubMed: 11740498]  [MGI Ref ID J:109187]

Gawronska-Kozak B; Bogacki M; Rim JS; Monroe WT; Manuel JA. 2006. Scarless skin repair in immunodeficient mice. Wound Repair Regen 14(3):265-76. [PubMed: 16808805]  [MGI Ref ID J:135709]

Glass WG; Subbarao K; Murphy B; Murphy PM. 2004. Mechanisms of host defense following severe acute respiratory syndrome-coronavirus (SARS-CoV) pulmonary infection of mice. J Immunol 173(6):4030-9. [PubMed: 15356152]  [MGI Ref ID J:92752]

Godfrey DI; Kennedy J; Mombaerts P; Tonegawa S; Zlotnik A. 1994. Onset of TCR-beta gene rearrangement and role of TCR-beta expression during CD3-CD4-CD8- thymocyte differentiation. J Immunol 152(10):4783-92. [PubMed: 7513723]  [MGI Ref ID J:18038]

Gramaglia I; Sahlin H; Nolan JP; Frangos JA; Intaglietta M; van der Heyde HC. 2005. Cell- rather than antibody-mediated immunity leads to the development of profound thrombocytopenia during experimental Plasmodium berghei malaria. J Immunol 175(11):7699-707. [PubMed: 16301680]  [MGI Ref ID J:122163]

Green RS; Stone EL; Tenno M; Lehtonen E; Farquhar MG; Marth JD. 2007. Mammalian N-Glycan Branching Protects against Innate Immune Self-Recognition and Inflammation in Autoimmune Disease Pathogenesis. Immunity 27(2):308-20. [PubMed: 17681821]  [MGI Ref ID J:124348]

Grisotto MG; Garin A; Martin AP; Jensen KK; Chan P; Sealfon SC; Lira SA. 2006. The human herpesvirus 8 chemokine receptor vGPCR triggers autonomous proliferation of endothelial cells. J Clin Invest 116(5):1264-73. [PubMed: 16604194]  [MGI Ref ID J:108952]

Grosse J; Chitu V; Marquardt A; Hanke P; Schmittwolf C; Zeitlmann L; Schropp P; Barth B; Yu P; Paffenholz R; Stumm G; Nehls M; Stanley ER. 2006. Mutation of mouse Mayp/Pstpip2 causes a macrophage autoinflammatory disease. Blood 107(8):3350-8. [PubMed: 16397132]  [MGI Ref ID J:125785]

Grossman WJ; Verbsky JW; Yang L; Berg LJ; Fields LE; Chaplin DD; Ratner L. 1999. Dysregulated myelopoiesis in mice lacking Jak3. Blood 94(3):932-9. [PubMed: 10419884]  [MGI Ref ID J:56629]

Guidos CJ; Williams CJ; Wu GE; Paige CJ; Danska JS. 1995. Development of CD4+CD8+ thymocytes in RAG-deficient mice through a T cell receptor beta chain-independent pathway. J Exp Med 181(3):1187-95. [PubMed: 7869035]  [MGI Ref ID J:23343]

Guzik TJ; Hoch NE; Brown KA; McCann LA; Rahman A; Dikalov S; Goronzy J; Weyand C; Harrison DG. 2007. Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction. J Exp Med 204(10):2449-60. [PubMed: 17875676]  [MGI Ref ID J:126052]

Hadeiba H; Locksley RM. 2003. Lung CD25 CD4 regulatory T cells suppress type 2 immune responses but not bronchial hyperreactivity. J Immunol 170(11):5502-10. [PubMed: 12759427]  [MGI Ref ID J:109990]

Hager-Theodorides AL; Rowbotham NJ; Outram SV; Dessens JT; Crompton T. 2007. beta-Selection: Abundance of TCRbeta(-)/gammadelta(-) CD44(-)CD25(-) (DN4) cells in the foetal thymus. Eur J Immunol 37(2):487-500. [PubMed: 17273993]  [MGI Ref ID J:117902]

Haks MC; Krimpenfort P; van den Brakel JH; Kruisbeek AM. 1999. Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells. Immunity 11(1):91-101. [PubMed: 10435582]  [MGI Ref ID J:110456]

Hanano R; Kaufmann SH. 1999. Effect on parasite eradication of Pneumocystis carinii-specific antibodies produced in the presence or absence of CD4(+) alphabeta T lymphocytes. Eur J Immunol 29(8):2464-75. [PubMed: 10458760]  [MGI Ref ID J:115322]

Hayward SL; Bautista-Lopez N; Suzuki K; Atrazhev A; Dickie P; Elliott JF. 2006. CD4 T cells play major effector role and CD8 T cells initiating role in spontaneous autoimmune myocarditis of HLA-DQ8 transgenic IAb knockout nonobese diabetic mice. J Immunol 176(12):7715-25. [PubMed: 16751419]  [MGI Ref ID J:113267]

Hobbs NK; Bondareva AA; Barnett S; Capecchi MR; Schmidt EE. 2002. Removing the Vertebrate-Specific TBP N Terminus Disrupts Placental beta2m-Dependent Interactions with the Maternal Immune System. Cell 110(1):43-54. [PubMed: 12150996]  [MGI Ref ID J:77714]

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