Strain Name:

C.Cg-Tcratm1Mom Tcrbtm1Mom/J

Stock Number:

004364

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Availability:

Cryopreserved - Ready for recovery

Use Restrictions Apply, see Terms of Use

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
 
Donating Investigator Maria Lafaille,   New York Un School of Medicine

Description
Mice that are homozygous for the targeted mutation are viable and fertile. Mutant mice display early stage arrest of alpha beta thymocyte differentiation. Mice may develop inflammatory bowel disease.

Development
For details related to the construction of each allele, please refer to the entries for strains 002116 and 002118.

Related Strains

Strains carrying   Tcratm1Mom allele
002116   B6.129S2-Tcratm1Mom/J
002115   B6;129S2-Tcratm1Mom/J
View Strains carrying   Tcratm1Mom     (2 strains)

View Strains carrying   Tcrbtm1Mom     (6 strains)

Strains carrying other alleles of Tcra
005308   B10.Cg-H2d Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005895   B10.Cg-Thy1a H2d Tg(TcraCl1,TcrbCl1)1Shrm/J
002761   B10.Cg-Tg(TcrAND)53Hed/J
003147   B10.D2-Hc1 H2d H2-T18c/nSnJ-Tg(DO11.10)10Dlo/J
003199   B10.PL-H2u H2-T18a/(73NS)Sn-Tg(TCRA)B1Jg/J
022073   B6.Cg-Rag1tm1Mom Thy1a Tg(Tcra2C,Tcrb2C)1Dlo/J
008684   B6.Cg-Rag1tm1Mom Tyrp1B-w Tg(Tcra,Tcrb)9Rest/J
014550   B6.Cg-Thy1a Tg(TcraCWM5,TcrbCWM5)1807Wuth/J
005023   B6.Cg-Thy1a/Cy Tg(TcraTcrb)8Rest/J
005655   B6.Cg-Tg(Tcra,Tcrb)3Ayr/J
008428   B6.Cg-Tg(Tcra,Tcrb)HRCAll/J
008429   B6.Cg-Tg(Tcra,Tcrb)HRVAll/J
008006   B6.Cg-Tg(Tcra51-11.5,Tcrb51-11.5)AR206Ayr/J
004194   B6.Cg-Tg(TcraTcrb)425Cbn/J
005236   B6.Cg-Tg(TcraY1,TcrbY1)416Tev/J
004554   B6.NOD-(D17Mit21-D17Mit10) Tg(TCRaAI4)1Dvs/DvsJ
004694   B6;D2-Tg(TcrLCMV)327Sdz/JDvsJ
002408   B6;SJL-Tg(TcrAND)53Hed/J
007848   BXSB.129P2(Cg)-Tcratm1Mjo/TheoJ
021880   BXSB.B6-Tg(TcraTcrb)1100Mjb/DcrJ
003303   C.Cg-Tg(DO11.10)10Dlo/J
002045   C.SJL-Tcrac/SlkJ
002047   C.SJL-Tcrba Tcrac/SlkJ
014639   C57BL/6-Tg(Cd4-TcraDN32D3)1Aben/J
011005   C57BL/6-Tg(H2-Kb-Tcra,-Tcrb)P25Ktk/J
006912   C57BL/6-Tg(Tcra2D2,Tcrb2D2)1Kuch/J
003831   C57BL/6-Tg(TcraTcrb)1100Mjb/J
005307   CBy.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005922   CBy.Cg-Thy1a Tg(TcraCl1,TcrbCl1)1Shrm/J
005694   D1Lac.Cg-Tg(Tcra,Tcrb)24Efro/J
017314   NOD-Tg(TcraTcrb)2H6Lwn/J
004444   NOD.129P2(C)-Tcratm1Mjo/DoiJ
006436   NOD.Cg-(Gpi1-D7Mit346)C57BL/6J Tg(TcraAI4)1Dvs/DvsJ
026243   NOD.Cg-(D9rs4135590-D9rs13480186)H2k2Tg(ILK3mHEL)3Ccg Tg(TcrHEL3A9)1Mmd/SlsgJ
026624   NOD.Cg-(D9rs6385855-D9rs13480186)H2k2Tg(ILK3mHEL)3Ccg Tg(TcrHEL3A9)1Mmd/SlsgJ
004257   NOD.Cg-Prkdcscid Tg(TcrLCMV)327Sdz/DvsJ
004347   NOD.Cg-Rag1tm1Mom Tg(TcraAI4)1Dvs/DvsJ
009377   NOD.Cg-Rag1tm1Mom Tg(TcraBDC12-4.1)10Jos Tg(TcrbBDC12-4.1)82Gse/J
024476   NOD.Cg-Stat4tm1Gru Thy1a Ifngr1tm1Agt Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/LmbrJ
005686   NOD.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
004696   NOD.Cg-Tg(TcrLCMV)327Sdz/DvsJ
004460   NOD.Cg-Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/DoiJ
010526   NOD.Cg-Tg(TcraTcrbNY4.1)1Pesa/DvsJ
005868   NOD.Cg-Tg(TcraTcrbNY8.3)1Pesa/DvsJ
006303   NOD.FVB-Tg(TcraBDC12-4.1)10Jos/GseJ
004334   NOD/ShiLt-Tg(TcraAI4)1Dvs
018030   SJL.Cg-Tg(TcraTcrbVP2)1Bkim/J
002597   STOCK Tg(TcrHEL3A9)1Mmd/J
View Strains carrying other alleles of Tcra     (48 strains)

Strains carrying other alleles of Tcrb
005308   B10.Cg-H2d Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005895   B10.Cg-Thy1a H2d Tg(TcraCl1,TcrbCl1)1Shrm/J
002761   B10.Cg-Tg(TcrAND)53Hed/J
003147   B10.D2-Hc1 H2d H2-T18c/nSnJ-Tg(DO11.10)10Dlo/J
003200   B10.PL-H2u H2-T18a/(73NS)Sn-Tg(TCRB)C14Jg/J
022073   B6.Cg-Rag1tm1Mom Thy1a Tg(Tcra2C,Tcrb2C)1Dlo/J
008684   B6.Cg-Rag1tm1Mom Tyrp1B-w Tg(Tcra,Tcrb)9Rest/J
014550   B6.Cg-Thy1a Tg(TcraCWM5,TcrbCWM5)1807Wuth/J
005023   B6.Cg-Thy1a/Cy Tg(TcraTcrb)8Rest/J
005655   B6.Cg-Tg(Tcra,Tcrb)3Ayr/J
008428   B6.Cg-Tg(Tcra,Tcrb)HRCAll/J
008429   B6.Cg-Tg(Tcra,Tcrb)HRVAll/J
008006   B6.Cg-Tg(Tcra51-11.5,Tcrb51-11.5)AR206Ayr/J
004194   B6.Cg-Tg(TcraTcrb)425Cbn/J
005236   B6.Cg-Tg(TcraY1,TcrbY1)416Tev/J
008430   B6.Cg-Tg(Tcrb)HRBAll/J
004555   B6.NOD-(D17Mit21-D17Mit10) Tg(TCRbAI4)1Dvs/DvsJ
004694   B6;D2-Tg(TcrLCMV)327Sdz/JDvsJ
002408   B6;SJL-Tg(TcrAND)53Hed/J
021880   BXSB.B6-Tg(TcraTcrb)1100Mjb/DcrJ
003303   C.Cg-Tg(DO11.10)10Dlo/J
002047   C.SJL-Tcrba Tcrac/SlkJ
002046   C.SJL-Tcrba/SlkJ
011005   C57BL/6-Tg(H2-Kb-Tcra,-Tcrb)P25Ktk/J
006912   C57BL/6-Tg(Tcra2D2,Tcrb2D2)1Kuch/J
003831   C57BL/6-Tg(TcraTcrb)1100Mjb/J
003540   C57L/J-Tg(Tcrb)93Vbo/J
005307   CBy.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005922   CBy.Cg-Thy1a Tg(TcraCl1,TcrbCl1)1Shrm/J
005694   D1Lac.Cg-Tg(Tcra,Tcrb)24Efro/J
017314   NOD-Tg(TcraTcrb)2H6Lwn/J
006437   NOD.Cg-(Gpi1-D7Mit346)C57BL/6J Tg(TcrbAI4)1Dvs/DvsJ
026243   NOD.Cg-(D9rs4135590-D9rs13480186)H2k2Tg(ILK3mHEL)3Ccg Tg(TcrHEL3A9)1Mmd/SlsgJ
026624   NOD.Cg-(D9rs6385855-D9rs13480186)H2k2Tg(ILK3mHEL)3Ccg Tg(TcrHEL3A9)1Mmd/SlsgJ
004257   NOD.Cg-Prkdcscid Tg(TcrLCMV)327Sdz/DvsJ
009377   NOD.Cg-Rag1tm1Mom Tg(TcraBDC12-4.1)10Jos Tg(TcrbBDC12-4.1)82Gse/J
024476   NOD.Cg-Stat4tm1Gru Thy1a Ifngr1tm1Agt Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/LmbrJ
005686   NOD.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
004696   NOD.Cg-Tg(TcrLCMV)327Sdz/DvsJ
004460   NOD.Cg-Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/DoiJ
010526   NOD.Cg-Tg(TcraTcrbNY4.1)1Pesa/DvsJ
005868   NOD.Cg-Tg(TcraTcrbNY8.3)1Pesa/DvsJ
006304   NOD.FVB-Tg(TcrbBDC12-4.1)82Gse/GseJ
004335   NOD/ShiLt-Tg(TcrbAI4)1Dvs
018030   SJL.Cg-Tg(TcraTcrbVP2)1Bkim/J
002597   STOCK Tg(TcrHEL3A9)1Mmd/J
View Strains carrying other alleles of Tcrb     (46 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Tcratm1Mom/Tcratm1Mom

        B6.129S2-Tcratm1Mom
  • immune system phenotype
  • abnormal response to transplant
    • mice fail to reject tail skin from OVA expressing transgenic mice ( Tg(CAG-OVA)916Jen )   (MGI Ref ID J:91742)
  • colitis
    • a disease similar to ulcerative colitis occurs in these mice with histology revealing inflammation and elongation of the crypts   (MGI Ref ID J:135597)
  • increased mature gamma-delta T cell number
    • there are 20-fold more gammadelta T cells found in the lamina propia of the gut compared to wild-type mice   (MGI Ref ID J:135597)
  • increased susceptibility to bacterial infection
    • greatly increased susceptibility to infection with Mycobacterium paratuberculosis   (MGI Ref ID J:106241)
  • digestive/alimentary phenotype
  • abnormal large intestine morphology
    • colitis results in lengthening of the colon   (MGI Ref ID J:135597)
    • the large intestine weight to body weight ratio at 28 weeks of age is twice as great than what is observed in wild-type mice   (MGI Ref ID J:135597)
    • rectal prolapse
      • rectal prolapse occurs in about 18% of mice 24 to 60 weeks of age   (MGI Ref ID J:135597)
  • colitis
    • a disease similar to ulcerative colitis occurs in these mice with histology revealing inflammation and elongation of the crypts   (MGI Ref ID J:135597)
  • hematopoietic system phenotype
  • increased mature gamma-delta T cell number
    • there are 20-fold more gammadelta T cells found in the lamina propia of the gut compared to wild-type mice   (MGI Ref ID J:135597)

Tcratm1Mom/Tcratm1Mom Tcrbtm1Mom/Tcrbtm1Mom

        involves: 129 * BALB/c * C57BL/6
  • immune system phenotype
  • arrested T cell differentiation
    • most T cells in the thymus do no progress to the double negative stage   (MGI Ref ID J:3206)
  • decreased double-positive T cell number
    • double positive cells are not present   (MGI Ref ID J:3206)
  • thymus hypoplasia
    • about a 95% reduction in number of total thymocytes   (MGI Ref ID J:3206)
  • hematopoietic system phenotype
  • arrested T cell differentiation
    • most T cells in the thymus do no progress to the double negative stage   (MGI Ref ID J:3206)
  • decreased double-positive T cell number
    • double positive cells are not present   (MGI Ref ID J:3206)
  • thymus hypoplasia
    • about a 95% reduction in number of total thymocytes   (MGI Ref ID J:3206)
  • endocrine/exocrine gland phenotype
  • thymus hypoplasia
    • about a 95% reduction in number of total thymocytes   (MGI Ref ID J:3206)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Research Tools
Immunology, Inflammation and Autoimmunity Research
      T Cell Receptor Deficiency

Tcratm1Mom related

Hematological Research
Immunological Defects

Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunodeficiency
Inflammation
      Inflammatory bowel disease
T Cell Receptor Signaling Defects

Research Tools
Cancer Research
      specific T cell deficiency

Tcrbtm1Mom related

Hematological Research
Immunological Defects

Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunodeficiency
Inflammation
      Inflammatory bowel disease
T Cell Receptor Signaling Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Tcratm1Mom
Allele Name targeted mutation 1, Peter Mombaerts
Allele Type Targeted (Null/Knockout)
Common Name(s) C-alpha-; TCR Calpha-; TCR alpha-; TCR alpha0; TCRmini; TCRalpha KO; TCRalpha-; alpha-;
Mutation Made By Peter Mombaerts,   Max Planck Research Unit for Neurogenetics
Strain of Origin129S2/SvPas
ES Cell Line NameD3
ES Cell Line Strain129S2/SvPas
Gene Symbol and Name Tcra, T cell receptor alpha chain
Chromosome 14
Gene Common Name(s) Tcr alpha; Tcralpha;
General Note Phenotypic Similarity to Human Syndrome: Inflammatory Bowel Disease (J:15221, J:135597)
Molecular Note A PGK-neo cassette was used to disrupt exon 1, which encodes the majority of the extracellular domain. The targeting event was confirmed by Southern analysis. [MGI Ref ID J:113136] [MGI Ref ID J:126027] [MGI Ref ID J:3206]
 
Allele Symbol Tcrbtm1Mom
Allele Name targeted mutation 1, Peter Mombaerts
Allele Type Targeted (Null/Knockout)
Common Name(s) CBeta-; TCR-Cbeta-; TCRb-; TCRbeta-; beta-;
Mutation Made By Peter Mombaerts,   Max Planck Research Unit for Neurogenetics
Strain of Origin129P2/OlaHsd
ES Cell Line NameE14
ES Cell Line Strain129P2/OlaHsd
Gene Symbol and Name Tcrb, T cell receptor beta chain
Chromosome 6
Gene Common Name(s) TCRbeta; Tib;
Molecular Note 15kb of sequence was replaced with a PGK-neo cassette. The deletion included one of the two D gene segments, ten of the twelve J gene segments, and both constant gene segments. [MGI Ref ID J:22591]

Genotyping

Genotyping Information

Genotyping Protocols

Tcratm1Momalternate3, Standard PCR
Tcrbtm1Mom,

MELT


Tcrbtm1Mom, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Curotto de Lafaille MA; Muriglan S; Sunshine MJ; Lei Y; Kutchukhidze N; Furtado GC; Wensky AK; Olivares-Villagomez D; Lafaille JJ. 2001. Hyper immunoglobulin E response in mice with monoclonal populations of B and T lymphocytes. J Exp Med 194(9):1349-59. [PubMed: 11696599]  [MGI Ref ID J:100072]

Additional References

Tcratm1Mom related

Akue AD; Lee JY; Jameson SC. 2012. Derivation and maintenance of virtual memory CD8 T cells. J Immunol 188(6):2516-23. [PubMed: 22308307]  [MGI Ref ID J:181867]

Albu DI; Feng D; Bhattacharya D; Jenkins NA; Copeland NG; Liu P; Avram D. 2007. BCL11B is required for positive selection and survival of double-positive thymocytes. J Exp Med 204(12):3003-15. [PubMed: 17998389]  [MGI Ref ID J:128515]

Almeida AR; Borghans JA; Freitas AA. 2001. T cell homeostasis: thymus regeneration and peripheral T cell restoration in mice with a reduced fraction of competent precursors. J Exp Med 194(5):591-9. [PubMed: 11535628]  [MGI Ref ID J:118033]

Almeida AR; Legrand N; Papiernik M; Freitas AA. 2002. Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers. J Immunol 169(9):4850-60. [PubMed: 12391195]  [MGI Ref ID J:125748]

Alves NL; Huntington ND; Mention JJ; Richard-Le Goff O; Di Santo JP. 2010. Cutting Edge: a thymocyte-thymic epithelial cell cross-talk dynamically regulates intrathymic IL-7 expression in vivo. J Immunol 184(11):5949-53. [PubMed: 20439914]  [MGI Ref ID J:161220]

Arnold CN; Campbell DJ; Lipp M; Butcher EC. 2007. The germinal center response is impaired in the absence of T cell-expressed CXCR5. Eur J Immunol 37(1):100-9. [PubMed: 17171760]  [MGI Ref ID J:117042]

Auger JL; Haasken S; Steinert EM; Binstadt BA. 2012. Incomplete TCR-beta allelic exclusion accelerates spontaneous autoimmune arthritis in K/BxN TCR transgenic mice. Eur J Immunol 42(9):2354-62. [PubMed: 22706882]  [MGI Ref ID J:187944]

Aurora AB; Baluk P; Zhang D; Sidhu SS; Dolganov GM; Basbaum C; McDonald DM; Killeen N. 2005. Immune complex-dependent remodeling of the airway vasculature in response to a chronic bacterial infection. J Immunol 175(10):6319-26. [PubMed: 16272283]  [MGI Ref ID J:119344]

Baccala R; Witherden D; Gonzalez-Quintial R; Dummer W; Surh CD; Havran WL; Theofilopoulos AN. 2005. Gamma delta T cell homeostasis is controlled by IL-7 and IL-15 together with subset-specific factors. J Immunol 174(8):4606-12. [PubMed: 15814683]  [MGI Ref ID J:98166]

Bailey-Bucktrout SL; Martinez-Llordella M; Zhou X; Anthony B; Rosenthal W; Luche H; Fehling HJ; Bluestone JA. 2013. Self-antigen-driven activation induces instability of regulatory T cells during an inflammatory autoimmune response. Immunity 39(5):949-62. [PubMed: 24238343]  [MGI Ref ID J:208984]

Baldwin TA; Sandau MM; Jameson SC; Hogquist KA. 2005. The timing of TCR alpha expression critically influences T cell development and selection. J Exp Med 202(1):111-21. [PubMed: 15998791]  [MGI Ref ID J:100651]

Bandukwala HS; Gagnon J; Togher S; Greenbaum JA; Lamperti ED; Parr NJ; Molesworth AM; Smithers N; Lee K; Witherington J; Tough DF; Prinjha RK; Peters B; Rao A. 2012. Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors. Proc Natl Acad Sci U S A 109(36):14532-7. [PubMed: 22912406]  [MGI Ref ID J:189876]

Barber DL; Mayer-Barber KD; Feng CG; Sharpe AH; Sher A. 2011. CD4 T cells promote rather than control tuberculosis in the absence of PD-1-mediated inhibition. J Immunol 186(3):1598-607. [PubMed: 21172867]  [MGI Ref ID J:168927]

Baron JL; Gardiner L; Nishimura S; Shinkai K; Locksley R; Ganem D. 2002. Activation of a nonclassical NKT cell subset in a transgenic mouse model of hepatitis B virus infection. Immunity 16(4):583-94. [PubMed: 11970881]  [MGI Ref ID J:113520]

Baur N; Nerz G; Nil A; Eichmann K. 2001. Expression and selection of productively rearranged TCRbeta VDJ genes are sequentially regulated by CD3 signaling in the development of NK1.1(+) alphabeta T cells. Int Immunol 13(8):1031-42. [PubMed: 11470773]  [MGI Ref ID J:71151]

Bedel R; Berry R; Mallevaey T; Matsuda JL; Zhang J; Godfrey DI; Rossjohn J; Kappler JW; Marrack P; Gapin L. 2014. Effective functional maturation of invariant natural killer T cells is constrained by negative selection and T-cell antigen receptor affinity. Proc Natl Acad Sci U S A 111(1):E119-28. [PubMed: 24344267]  [MGI Ref ID J:206291]

Bessette K; Lang ML; Fava RA; Grundy M; Heinen J; Horne L; Spolski R; Al-Shami A; Morse HC 3rd; Leonard WJ; Kelly JA. 2008. A Stat5b transgene is capable of inducing CD8+ lymphoblastic lymphoma in the absence of normal TCR/MHC signaling. Blood 111(1):344-50. [PubMed: 17890450]  [MGI Ref ID J:129993]

Bowen S; Sun P; Livak F; Sharrow S; Hodes RJ. 2014. A novel T cell subset with trans-rearranged Vgamma-Cbeta TCRs shows Vbeta expression is dispensable for lineage choice and MHC restriction. J Immunol 192(1):169-77. [PubMed: 24307734]  [MGI Ref ID J:207166]

Brodeur JF; Li S; Damlaj O; Dave VP. 2009. Expression of fully assembled TCR-CD3 complex on double positive thymocytes: synergistic role for the PRS and ER retention motifs in the intra-cytoplasmic tail of CD3epsilon. Int Immunol 21(12):1317-27. [PubMed: 19819936]  [MGI Ref ID J:155472]

Buch T; Rieux-Laucat F; Forster I; Rajewsky K. 2002. Failure of HY-specific thymocytes to escape negative selection by receptor editing. Immunity 16(5):707-18. [PubMed: 12049722]  [MGI Ref ID J:81564]

Burchill MA; Yang J; Vang KB; Moon JJ; Chu HH; Lio CW; Vegoe AL; Hsieh CS; Jenkins MK; Farrar MA. 2008. Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire. Immunity 28(1):112-21. [PubMed: 18199418]  [MGI Ref ID J:131384]

Burich A; Hershberg R; Waggie K; Zeng W; Brabb T; Westrich G; Viney JL; Maggio-Price L. 2001. Helicobacter-induced inflammatory bowel disease in IL-10- and T cell-deficient mice. Am J Physiol Gastrointest Liver Physiol 281(3):G764-78. [PubMed: 11518689]  [MGI Ref ID J:108283]

Cai Y; Shen X; Ding C; Qi C; Li K; Li X; Jala VR; Zhang HG; Wang T; Zheng J; Yan J. 2011. Pivotal Role of Dermal IL-17-Producing gammadelta T Cells in Skin Inflammation. Immunity 35(4):596-610. [PubMed: 21982596]  [MGI Ref ID J:177652]

Candeias S; Peschon JJ; Muegge K; Durum SK. 1997. Defective T-cell receptor gamma gene rearrangement in interleukin-7 receptor knockout mice. Immunol Lett 57(1-3):9-14. [PubMed: 9232418]  [MGI Ref ID J:42227]

Cebula A; Seweryn M; Rempala GA; Pabla SS; McIndoe RA; Denning TL; Bry L; Kraj P; Kisielow P; Ignatowicz L. 2013. Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota. Nature 497(7448):258-62. [PubMed: 23624374]  [MGI Ref ID J:198754]

Chandler P; Frater AJ; Douek DC; Viney JL; Kay G; Owen MJ; Hayday AC; Simpson E; Altmann DM. 1995. Immune responsiveness in mutant mice lacking T-cell receptor alpha beta+ cells. Immunology 85(4):531-7. [PubMed: 7558145]  [MGI Ref ID J:28872]

Chang D; Valdez P; Ho T; Robey E. 2000. MHC recognition in thymic development: distinct, parallel pathways for survival and lineage commitment J Immunol 165(12):6710-5. [PubMed: 11120788]  [MGI Ref ID J:66168]

Chapman TJ; Topham DJ. 2010. Identification of a unique population of tissue-memory CD4+ T cells in the airways after influenza infection that is dependent on the integrin VLA-1. J Immunol 184(7):3841-9. [PubMed: 20200271]  [MGI Ref ID J:160079]

Chen Y; Chou K; Fuchs E; Havran WL; Boismenu R. 2002. Protection of the intestinal mucosa by intraepithelial gamma delta T cells. Proc Natl Acad Sci U S A 99(22):14338-43. [PubMed: 12376619]  [MGI Ref ID J:125077]

Chen Y; Cuda C; Morel L. 2005. Genetic determination of T cell help in loss of tolerance to nuclear antigens. J Immunol 174(12):7692-702. [PubMed: 15944270]  [MGI Ref ID J:100863]

Cheng G; Yuan X; Tsai MS; Podack ER; Yu A; Malek TR. 2012. IL-2 receptor signaling is essential for the development of Klrg1+ terminally differentiated T regulatory cells. J Immunol 189(4):1780-91. [PubMed: 22786769]  [MGI Ref ID J:189754]

Chennupati V; Worbs T; Liu X; Malinarich FH; Schmitz S; Haas JD; Malissen B; Forster R; Prinz I. 2010. Intra- and intercompartmental movement of gammadelta T cells: intestinal intraepithelial and peripheral gammadelta T cells represent exclusive nonoverlapping populations with distinct migration characteristics. J Immunol 185(9):5160-8. [PubMed: 20870939]  [MGI Ref ID J:165201]

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Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryIndividual constituent strains originated on a B6;129, were made congenic on the C57BL/6 background, were backcrossed once onto B10.PL-H2u H2-T18a(73NS)/Sn (00458) and then backcrossed for 7 generations on the BALB/c background. Specific pathogen-free (SPF) conditions are recommended.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3300.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $4290.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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