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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
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Description
Strain Information
Type Congenic; Mutant Strain; Targeted Mutation; Additional information on Genetically Engineered Mutant Mice. Species laboratory mouse Generation N7F?+N1 Donating Investigator Maria Lafaille, New York Un School of Medicine Description
Mice that are homozygous for the targeted mutation are viable and fertile. Mutant mice display early stage arrest of alpha beta thymocyte differentiation. Mice may develop inflammatory bowel disease.Development
For details related to the construction of each allele, please refer to the entries for strains 002116 and 002118.
Related Strains
Strains carrying Tcratm1Mom allele
002116 B6.129S2-Tcratm1Mom/J 002115 B6;129S2-Tcratm1Mom/J View Strains carrying Tcratm1Mom (2 strains)
002122 B6.129P2-Tcrbtm1Mom Tcrdtm1Mom/J 002118 B6.129P2-Tcrbtm1Mom/J 002121 B6;129P-Tcrbtm1Mom Tcrdtm1Mom/J 002117 B6;129P2-Tcrbtm1Mom/J 003447 CBy.129P2(B6)-Tcrbtm1Mom/SzJ 007081 CByJ.129P2(B6)-Tcrbtm1Mom/J
Additional Web Information
Congenic Nomenclature
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Tcratm1Mom/Tcratm1Mom
B6.129S2-Tcratm1Mom
- immune system phenotype
- abnormal response to transplant (MGI Ref ID J:91742)
- mice fail to reject tail skin from OVA expressing transgenic mice ( Tg(CAG-OVA)916Jen )
- increased susceptibility to bacterial infection (MGI Ref ID J:106241)
- greatly increased susceptibility to infection with Mycobacterium paratuberculosis
Tcratm1Mom/Tcratm1Mom Tcrbtm1Mom/Tcrbtm1Mom
involves: 129P2/OlaHsd * 129S2/SvPas
- immune system phenotype
- abnormal immune system cell morphology (MGI Ref ID J:3206)
- abnormal immune system organ morphology (MGI Ref ID J:3206)
Tcratm1Mom/Tcratm1Mom Tcrbtm1Mom/Tcrbtm1Mom
involves: 129 * BALB/c * C57BL/6
- immune system phenotype
- arrested T cell differentiation (MGI Ref ID J:3206)
- most T cells in the thymus do no progress to the double negative stage
- decreased double-positive T cell number (MGI Ref ID J:3206)
- double positive cells are not present
- thymus hypoplasia (MGI Ref ID J:3206)
- about a 95% reduction in number of total thymocytes
- hematopoietic system phenotype
- arrested T cell differentiation (MGI Ref ID J:3206)
- most T cells in the thymus do no progress to the double negative stage
- decreased double-positive T cell number (MGI Ref ID J:3206)
- double positive cells are not present
- thymus hypoplasia (MGI Ref ID J:3206)
- about a 95% reduction in number of total thymocytes
This mouse can be used to support research in many areas including:
Tcra relatedResearch Tools
Immunology and Inflammation Research (T Cell Receptor Deficiency)
Tcrb relatedImmunology and Inflammation Research
Inflammation
InflammationTcratm1Mom related
Tcrbtm1Mom relatedHematological Research
Immunological Defects
Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunodeficiency
Inflammation (Inflammatory bowel disease)
T Cell Receptor Signaling Defects
Research Tools
Cancer Research (specific T cell deficiency)
Hematological Research
Immunological Defects
Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunodeficiency
Inflammation (Inflammatory bowel disease)
T Cell Receptor Signaling Defects
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Tcratm1Mom | ||
|---|---|---|---|
| Allele Name | targeted mutation 1, Peter Mombaerts | ||
| Allele Type | Targeted (knock-out) | ||
| Common Name(s) | C-alpha-; TCR alpha-; TCR alpha<0>; TCRalpha KO; TCRalpha-; alpha-; | ||
| Mutation Made By | Peter Mombaerts, The Rockefeller University | ||
| Strain of Origin | 129S2/SvPas | ||
| ES Cell Line Name | D3 | ||
| ES Cell Line Strain | 129S2/SvPas | ||
| Gene Symbol and Name | Tcra, T-cell receptor alpha chain | ||
| Chromosome | 14 | ||
| Gene Common Name(s) | OTTMUSG00000015028; Tcr alpha; Tcralpha; predicted gene, OTTMUSG00000015028; | ||
| Molecular Note | A PGK-neo cassette was used to disrupt exon 1, which encodes the majority of the extracellular domain. The targeting event was confirmed by Southern analysis. [MGI Ref ID J:113136] [MGI Ref ID J:126027] [MGI Ref ID J:3206] | ||
| Allele Symbol | Tcrbtm1Mom | ||
| Allele Name | targeted mutation 1, Peter Mombaerts | ||
| Allele Type | Targeted (knock-out) | ||
| Common Name(s) | TCR-Cbeta-; TCRbeta-; beta-; | ||
| Mutation Made By | Peter Mombaerts, Max Planck Institute of Biophysics | ||
| Strain of Origin | 129P2/OlaHsd | ||
| ES Cell Line Name | E14 | ||
| ES Cell Line Strain | 129P2/OlaHsd | ||
| Gene Symbol and Name | Tcrb, T-cell receptor beta chain | ||
| Chromosome | 6 | ||
| Gene Common Name(s) | TRB; Tib; | ||
| Molecular Note | 15kb of sequence was deleted by the insertion of a PGK-neo cassette. The deletion included one of the two D gene segments, ten of the twelve J gene segments, and both constant gene segments. [MGI Ref ID J:22591] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Tcratm1Mom, STD PCR, vers. 2
Tcrbtm1Mom, STD PCR, vers. 1
Helpful Links
Optimizing PCR Protocols
References
References
Selected Reference(s)
Curotto de Lafaille MA; Muriglan S; Sunshine MJ; Lei Y; Kutchukhidze N; Furtado GC; Wensky AK; Olivares-Villagomez D; Lafaille JJ. 2001. Hyper immunoglobulin E response in mice with monoclonal populations of B and T lymphocytes. J Exp Med 194(9):1349-59. [PubMed: 11696599] [MGI Ref ID J:100072]
Additional References
Tcratm1Mom relatedTcrbtm1Mom relatedAlbu DI; Feng D; Bhattacharya D; Jenkins NA; Copeland NG; Liu P; Avram D. 2007. BCL11B is required for positive selection and survival of double-positive thymocytes. J Exp Med 204(12):3003-15. [PubMed: 17998389] [MGI Ref ID J:128515]
Almeida AR; Borghans JA; Freitas AA. 2001. T cell homeostasis: thymus regeneration and peripheral T cell restoration in mice with a reduced fraction of competent precursors. J Exp Med 194(5):591-9. [PubMed: 11535628] [MGI Ref ID J:118033]
Almeida AR; Legrand N; Papiernik M; Freitas AA. 2002. Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers. J Immunol 169(9):4850-60. [PubMed: 12391195] [MGI Ref ID J:125748]
Arnold CN; Campbell DJ; Lipp M; Butcher EC. 2007. The germinal center response is impaired in the absence of T cell-expressed CXCR5. Eur J Immunol 37(1):100-9. [PubMed: 17171760] [MGI Ref ID J:117042]
Aurora AB; Baluk P; Zhang D; Sidhu SS; Dolganov GM; Basbaum C; McDonald DM; Killeen N. 2005. Immune complex-dependent remodeling of the airway vasculature in response to a chronic bacterial infection. J Immunol 175(10):6319-26. [PubMed: 16272283] [MGI Ref ID J:119344]
Baccala R; Witherden D; Gonzalez-Quintial R; Dummer W; Surh CD; Havran WL; Theofilopoulos AN. 2005. Gamma delta T cell homeostasis is controlled by IL-7 and IL-15 together with subset-specific factors. J Immunol 174(8):4606-12. [PubMed: 15814683] [MGI Ref ID J:98166]
Baldwin TA; Sandau MM; Jameson SC; Hogquist KA. 2005. The timing of TCR alpha expression critically influences T cell development and selection. J Exp Med 202(1):111-21. [PubMed: 15998791] [MGI Ref ID J:100651]
Baron JL; Gardiner L; Nishimura S; Shinkai K; Locksley R; Ganem D. 2002. Activation of a nonclassical NKT cell subset in a transgenic mouse model of hepatitis B virus infection. Immunity 16(4):583-94. [PubMed: 11970881] [MGI Ref ID J:113520]
Baur N; Nerz G; Nil A; Eichmann K. 2001. Expression and selection of productively rearranged TCRbeta VDJ genes are sequentially regulated by CD3 signaling in the development of NK1.1(+) alphabeta T cells. Int Immunol 13(8):1031-42. [PubMed: 11470773] [MGI Ref ID J:71151]
Bessette K; Lang ML; Fava RA; Grundy M; Heinen J; Horne L; Spolski R; Al-Shami A; Morse HC rd; Leonard WJ; Kelly JA. 2008. A Stat5b transgene is capable of inducing CD8+ lymphoblastic lymphoma in the absence of normal TCR/MHC signaling. Blood 111(1):344-50. [PubMed: 17890450] [MGI Ref ID J:129993]
Buch T; Rieux-Laucat F; Forster I; Rajewsky K. 2002. Failure of HY-specific thymocytes to escape negative selection by receptor editing. Immunity 16(5):707-18. [PubMed: 12049722] [MGI Ref ID J:81564]
Burchill MA; Yang J; Vang KB; Moon JJ; Chu HH; Lio CW; Vegoe AL; Hsieh CS; Jenkins MK; Farrar MA. 2008. Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire. Immunity 28(1):112-21. [PubMed: 18199418] [MGI Ref ID J:131384]
Burich A; Hershberg R; Waggie K; Zeng W; Brabb T; Westrich G; Viney JL; Maggio-Price L. 2001. Helicobacter-induced inflammatory bowel disease in IL-10- and T cell-deficient mice. Am J Physiol Gastrointest Liver Physiol 281(3):G764-78. [PubMed: 11518689] [MGI Ref ID J:108283]
Candeias S; Peschon JJ; Muegge K; Durum SK. 1997. Defective T-cell receptor gamma gene rearrangement in interleukin-7 receptor knockout mice. Immunol Lett 57(1-3):9-14. [PubMed: 9232418] [MGI Ref ID J:42227]
Chandler P; Frater AJ; Douek DC; Viney JL; Kay G; Owen MJ; Hayday AC; Simpson E; Altmann DM. 1995. Immune responsiveness in mutant mice lacking T-cell receptor alpha beta+ cells. Immunology 85(4):531-7. [PubMed: 7558145] [MGI Ref ID J:28872]
Chang D; Valdez P; Ho T; Robey E. 2000. MHC recognition in thymic development: distinct, parallel pathways for survival and lineage commitment J Immunol 165(12):6710-5. [PubMed: 11120788] [MGI Ref ID J:66168]
Chen Y; Chou K; Fuchs E; Havran WL; Boismenu R. 2002. Protection of the intestinal mucosa by intraepithelial gamma delta T cells. Proc Natl Acad Sci U S A 99(22):14338-43. [PubMed: 12376619] [MGI Ref ID J:125077]
Chen Y; Cuda C; Morel L. 2005. Genetic determination of T cell help in loss of tolerance to nuclear antigens. J Immunol 174(12):7692-702. [PubMed: 15944270] [MGI Ref ID J:100863]
Chin EY; Dangler CA; Fox JG; Schauer DB. 2000. Helicobacter hepaticus infection triggers inflammatory bowel disease in T cell receptor alphabeta mutant mice. Comp Med 50(6):586-94. [PubMed: 11200563] [MGI Ref ID J:66813]
Chinen T; Kobayashi T; Ogata H; Takaesu G; Takaki H; Hashimoto M; Yagita H; Nawata H; Yoshimura A. 2006. Suppressor of cytokine signaling-1 regulates inflammatory bowel disease in which both IFNgamma and IL-4 are involved. Gastroenterology 130(2):373-88. [PubMed: 16472593] [MGI Ref ID J:124924]
Chiu NM; Wang B; Kerksiek KM; Kurlander R; Pamer EG; Wang CR. 1999. The selection of M3-restricted T cells is dependent on M3 expression and presentation of N-formylated peptides in the thymus. J Exp Med 190(12):1869-78. [PubMed: 10601361] [MGI Ref ID J:131934]
Chung DR; Kasper DL; Panzo RJ; Chtinis T; Grusby MJ; Sayegh MH; Tzianabos AO. 2003. CD4+ T cells mediate abscess formation in intra-abdominal sepsis by an IL-17-dependent mechanism. J Immunol 170(4):1958-63. [PubMed: 12574364] [MGI Ref ID J:81809]
Coles MC; Raulet DH. 2000. NK1.1+ T cells in the liver arise in the thymus and are selected by interactions with class I molecules on CD4+CD8+ cells. J Immunol 164(5):2412-8. [PubMed: 10679077] [MGI Ref ID J:112051]
Croxford AL; Akilli-Ozturk O; Rieux-Laucat F; Forster I; Waisman A; Buch T. 2008. MHC-restricted T cell receptor signaling is required for alphabeta TCR replacement of the pre T cell receptor. Eur J Immunol 38(2):391-9. [PubMed: 18203137] [MGI Ref ID J:131357]
Czopik AK; Bynoe MS; Palm N; Raine CS; Medzhitov R. 2006. Semaphorin 7A is a negative regulator of T cell responses. Immunity 24(5):591-600. [PubMed: 16713976] [MGI Ref ID J:113360]
Deepe GS Jr; Gibbons RS. 2003. Protective and memory immunity to Histoplasma capsulatum in the absence of IL-10. J Immunol 171(10):5353-62. [PubMed: 14607938] [MGI Ref ID J:117988]
Deepe GS Jr; Gibbons RS. 2008. TNF-alpha antagonism generates a population of antigen-specific CD4+CD25+ T cells that inhibit protective immunity in murine histoplasmosis. J Immunol 180(2):1088-97. [PubMed: 18178849] [MGI Ref ID J:130944]
Dianda L; Gulbranson-Judge A; Pao W; Hayday AC; MacLennan IC; Owen MJ. 1996. Germinal center formation in mice lacking alpha beta T cells. Eur J Immunol 26(7):1603-7. [PubMed: 8766567] [MGI Ref ID J:113041]
Dillon SR; Schlissel MS. 2002. Partial restoration of B cell development in Jak-3(-/-) mice achieved by co-expression of IgH and E(mu)-myc transgenes. Int Immunol 14(8):893-904. [PubMed: 12147626] [MGI Ref ID J:78457]
Djuretic IM; Levanon D; Negreanu V; Groner Y; Rao A; Ansel KM. 2007. Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells. Nat Immunol 8(2):145-53. [PubMed: 17195845] [MGI Ref ID J:117861]
Ehst BD; Ingulli E; Jenkins MK. 2003. Development of a novel transgenic mouse for the study of interactions between CD4 and CD8 T cells during graft rejection. Am J Transplant 3(11):1355-62. [PubMed: 14525595] [MGI Ref ID J:91742]
Eichelberger M; McMickle A; Blackman M; Mombaerts P; Tonegawa S; Doherty PC. 1995. Functional analysis of the TCR alpha- beta+ cells that accumulate in the pneumonic lung of influenza virus-infected TCR-alpha-/- mice. J Immunol 154(4):1569-76. [PubMed: 7836742] [MGI Ref ID J:22818]
Ellmeier W; Sunshine MJ; Maschek R; Littman DR. 2002. Combined deletion of CD8 locus cis-regulatory elements affects initiation but not maintenance of CD8 expression. Immunity 16(5):623-34. [PubMed: 12049715] [MGI Ref ID J:113136]
Elyaman W; Kivisakk P; Reddy J; Chitnis T; Raddassi K; Imitola J; Bradshaw E; Kuchroo VK; Yagita H; Sayegh MH; Khoury SJ. 2008. Distinct functions of autoreactive memory and effector CD4+ T cells in experimental autoimmune encephalomyelitis. Am J Pathol 173(2):411-22. [PubMed: 18583313] [MGI Ref ID J:138298]
Fallah-Arani F; Schweighoffer E; Vanes L; Tybulewicz VL. 2008. Redundant role for Zap70 in B cell development and activation. Eur J Immunol 38(6):1721-33. [PubMed: 18465772] [MGI Ref ID J:136323]
Feik N; Bilic I; Tinhofer J; Unger B; Littman DR; Ellmeier W. 2005. Functional and molecular analysis of the double-positive stage-specific CD8 enhancer E8III during thymocyte development. J Immunol 174(3):1513-24. [PubMed: 15661911] [MGI Ref ID J:126027]
Fritz RB; Zhao ML. 2001. Regulation of experimental autoimmune encephalomyelitis in the C57BL/6J mouse by NK1.1+, DX5+, alpha beta+ T cells. J Immunol 166(6):4209-15. [PubMed: 11238673] [MGI Ref ID J:126134]
Gaszewska-Mastalarz A; Muranski P; Chmielowski B; Kraj P; Ignatowicz L. 2000. Altered selection of CD4+ T cells by class II MHC bound with dominant and low abundance self-peptides. J Immunol 165(11):6099-106. [PubMed: 11086042] [MGI Ref ID J:118564]
Gavin MA; Clarke SR; Negrou E; Gallegos A; Rudensky A. 2002. Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivo. Nat Immunol 3(1):33-41. [PubMed: 11740498] [MGI Ref ID J:109187]
Godfrey DI; Kennedy J; Mombaerts P; Tonegawa S; Zlotnik A. 1994. Onset of TCR-beta gene rearrangement and role of TCR-beta expression during CD3-CD4-CD8- thymocyte differentiation. J Immunol 152(10):4783-92. [PubMed: 7513723] [MGI Ref ID J:18038]
Goux D; Coudert JD; Maurice D; Scarpellino L; Jeannet G; Piccolo S; Weston K; Huelsken J; Held W. 2005. Cooperating pre-T-cell receptor and TCF-1-dependent signals ensure thymocyte survival. Blood 106(5):1726-33. [PubMed: 15890681] [MGI Ref ID J:118496]
Haks MC; Belkowski SM; Ciofani M; Rhodes M; Lefebvre JM; Trop S; Hugo P; Zuniga-Pflucker JC; Wiest DL. 2003. Low activation threshold as a mechanism for ligand-independent signaling in pre-T cells. J Immunol 170(6):2853-61. [PubMed: 12626535] [MGI Ref ID J:126301]
Harvill ET; Osorio M; Loving CL; Lee GM; Kelly VK; Merkel TJ. 2008. Anamnestic protective immunity to Bacillus anthracis is antibody mediated but independent of complement and Fc receptors. Infect Immun 76(5):2177-82. [PubMed: 18316379] [MGI Ref ID J:134474]
Hayashi RJ; Kanagawa O. 1999. Unique CD4(+) T cells in TCR alpha chain-deficient class I MHC-restricted TCR transgenic mice: role in a superantigen-mediated disease process. Int Immunol 11(9):1581-90. [PubMed: 10464179] [MGI Ref ID J:57698]
Hayes SM; Li L; Love PE. 2005. TCR signal strength influences alphabeta/gammadelta lineage fate. Immunity 22(5):583-93. [PubMed: 15894276] [MGI Ref ID J:99104]
Hermiston ML; Tan AL; Gupta VA; Majeti R; Weiss A. 2005. The juxtamembrane wedge negatively regulates CD45 function in B cells. Immunity 23(6):635-47. [PubMed: 16356861] [MGI Ref ID J:113310]
Hikosaka Y; Nitta T; Ohigashi I; Yano K; Ishimaru N; Hayashi Y; Matsumoto M; Matsuo K; Penninger JM; Takayanagi H; Yokota Y; Yamada H; Yoshikai Y; Inoue J; Akiyama T; Takahama Y. 2008. The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator. Immunity 29(3):438-50. [PubMed: 18799150] [MGI Ref ID J:139648]
Hong NA; Cado D; Mitchell J; Ortiz BD; Hsieh SN; Winoto A. 1997. A targeted mutation at the T-cell receptor alpha/delta locus impairs T-cell development and reveals the presence of the nearby antiapoptosis gene Dad1. Mol Cell Biol 17(4):2151-7. [PubMed: 9121464] [MGI Ref ID J:77676]
Hori S; Haury M; Coutinho A; Demengeot J. 2002. Specificity requirements for selection and effector functions of CD25+4+ regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice. Proc Natl Acad Sci U S A 99(12):8213-8. [PubMed: 12034883] [MGI Ref ID J:126912]
Hsieh CS; Zheng Y; Liang Y; Fontenot JD; Rudensky AY. 2006. An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires. Nat Immunol 7(4):401-10. [PubMed: 16532000] [MGI Ref ID J:112554]
Iijima H; Takahashi I; Kishi D; Kim JK; Kawano S; Hori M; Kiyono H. 1999. Alteration of interleukin 4 production results in the inhibition of T helper type 2 cell-dominated inflammatory bowel disease in T cell receptor alpha chain-deficient mice. J Exp Med 190(5):607-15. [PubMed: 10477546] [MGI Ref ID J:57609]
Inagaki-Ohara K; Chinen T; Matsuzaki G; Sasaki A; Sakamoto Y; Hiromatsu K; Nakamura-Uchiyama F; Nawa Y; Yoshimura A. 2004. Mucosal T cells bearing TCRgammadelta play a protective role in intestinal inflammation. J Immunol 173(2):1390-8. [PubMed: 15240735] [MGI Ref ID J:91942]
Ito Y; Arai S; van Oers NS; Aifantis I; von Boehmer H; Miyazaki T. 2002. Positive selection by the pre-TCR yields mature CD8+ T cells. J Immunol 169(9):4913-9. [PubMed: 12391203] [MGI Ref ID J:111095]
Jung YJ; LaCourse R; Ryan L; North RJ. 2002. Virulent but not avirulent Mycobacterium tuberculosis can evade the growth inhibitory action of a T helper 1-dependent, nitric oxide Synthase 2-independent defense in mice. J Exp Med 196(7):991-8. [PubMed: 12370260] [MGI Ref ID J:119257]
Kawachi I; Maldonado J; Strader C; Gilfillan S. 2006. MR1-restricted V alpha 19i mucosal-associated invariant T cells are innate T cells in the gut lamina propria that provide a rapid and diverse cytokine response. J Immunol 176(3):1618-27. [PubMed: 16424191] [MGI Ref ID J:126605]
Kawaguchi-Miyashita M; Shimada S; Kurosu H; Kato-Nagaoka N; Matsuoka Y; Ohwaki M; Ishikawa H; Nanno M. 2001. An accessory role of TCRgammadelta (+) cells in the exacerbation of inflammatory bowel disease in TCRalpha mutant mice. Eur J Immunol 31(4):980-8. [PubMed: 11298322] [MGI Ref ID J:68810]
Kawikova I; Paliwal V; Szczepanik M; Itakura A; Fukui M; Campos RA; Geba GP; Homer RJ; Iliopoulou BP; Pober JS; Tsuji RF; Askenase PW. 2004. Airway hyper-reactivity mediated by B-1 cell immunoglobulin M antibody generating complement C5a at 1 day post-immunization in a murine hapten model of non-atopic asthma. Immunology 113(2):234-45. [PubMed: 15379984] [MGI Ref ID J:92933]
Kishi D; Takahashi I; Kai Y; Tamagawa H; Iijima H; Obunai S; Nezu R; Ito T; Matsuda H; Kiyono H. 2000. Alteration of V beta usage and cytokine production of CD4+ TCR beta beta homodimer T cells by elimination of Bacteroides vulgatus prevents colitis in TCR alpha-chain-deficient mice. J Immunol 165(10):5891-9. [PubMed: 11067950] [MGI Ref ID J:118384]
Kohyama M; Nanno M; Kawaguchi-Miyashita M; Shimada S; Watanabe M; Hibi T; Kaminogawa S; Ishikawa H. 1999. Cytolytic and IFN-gamma-producing activities of gamma delta T cells in the mouse intestinal epithelium are T cell receptor-beta-chain dependent. Proc Natl Acad Sci U S A 96(13):7451-5. [PubMed: 10377435] [MGI Ref ID J:56057]
Lambolez F; Azogui O; Joret AM; Garcia C; von Boehmer H; Di Santo J; Ezine S; Rocha B. 2002. Characterization of T cell differentiation in the murine gut. J Exp Med 195(4):437-49. [PubMed: 11854357] [MGI Ref ID J:124458]
Larkin J rd; Rankin AL; Picca CC; Riley MP; Jenks SA; Sant AJ; Caton AJ. 2008. CD4+CD25+ regulatory T cell repertoire formation shaped by differential presentation of peptides from a self-antigen. J Immunol 180(4):2149-57. [PubMed: 18250421] [MGI Ref ID J:131919]
Lee SK; Kadono Y; Okada F; Jacquin C; Koczon-Jaremko B; Gronowicz G; Adams DJ; Aguila HL; Choi Y; Lorenzo JA. 2006. T lymphocyte-deficient mice lose trabecular bone mass with ovariectomy. J Bone Miner Res 21(11):1704-12. [PubMed: 17002560] [MGI Ref ID J:128101]
Lemos MP; Esquivel F; Scott P; Laufer TM. 2004. MHC class II expression restricted to CD8alpha+ and CD11b+ dendritic cells is sufficient for control of Leishmania major. J Exp Med 199(5):725-30. [PubMed: 14993255] [MGI Ref ID J:123991]
Lindroth K; Troye-Blomberg M; Singh M; Dieli F; Ivanyi J; Fernandez C. 2002. The humoral response in TCR alpha-/- mice. Can gammadelta-T cells support the humoral immune response? Scand J Immunol 55(3):256-63. [PubMed: 11940232] [MGI Ref ID J:103683]
Logunova NN; Viret C; Pobezinsky LA; Miller SA; Kazansky DB; Sundberg JP; Chervonsky AV. 2005. Restricted MHC-peptide repertoire predisposes to autoimmunity. J Exp Med 202(1):73-84. [PubMed: 15998789] [MGI Ref ID J:100625]
Mao C; Tili EG; Dose M; Haks MC; Bear SE; Maroulakou I; Horie K; Gaitanaris GA; Fidanza V; Ludwig T; Wiest DL; Gounari F; Tsichlis PN. 2007. Unequal contribution of Akt isoforms in the double-negative to double-positive thymocyte transition. J Immunol 178(9):5443-53. [PubMed: 17442925] [MGI Ref ID J:135903]
Matsuda S; Kudoh S; Katayama S. 2001. Enhanced Formation of Azoxymethane-induced Colorectal Adenocarcinoma in gammadelta T Lymphocyte-deficient Mice. Jpn J Cancer Res 92(8):880-5. [PubMed: 11509121] [MGI Ref ID J:70900]
Matsuki Y; Zhang HG; Hsu HC; Yang PA; Zhou T; Dodd CH; Cecconi F; Gruss P; Tadakuma T; Mountz JD. 2002. Different role of Apaf-1 in positive selection, negative selection and death by neglect in foetal thymic organ culture. Scand J Immunol 56(2):174-84. [PubMed: 12121437] [MGI Ref ID J:133855]
McCaughtry TM; Baldwin TA; Wilken MS; Hogquist KA. 2008. Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla. J Exp Med 205(11):2575-84. [PubMed: 18936237] [MGI Ref ID J:140650]
McLoughlin RM; Solinga RM; Rich J; Zaleski KJ; Cocchiaro JL; Risley A; Tzianabos AO; Lee JC. 2006. CD4+ T cells and CXC chemokines modulate the pathogenesis of Staphylococcus aureus wound infections. Proc Natl Acad Sci U S A 103(27):10408-13. [PubMed: 16801559] [MGI Ref ID J:111690]
Mills JH; Thompson LF; Mueller C; Waickman AT; Jalkanen S; Niemela J; Airas L; Bynoe MS. 2008. CD73 is required for efficient entry of lymphocytes into the central nervous system during experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A 105(27):9325-30. [PubMed: 18591671] [MGI Ref ID J:138192]
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