Description

Strain Information

Former Names C57BL/6J-Chr 13A/NaJ    (Changed: 19-SEP-06 ) C57BL/6J-13A/Na    (Changed: 15-DEC-04 ) Type Consomic; Additional information on Consomic Mice. Visit our online Nomenclature tutorial. Mating System Sibling x Sibling         (Female x Male)   01-MAR-06 Species laboratory mouse Background Strain C57BL/6J Donor Strain A/J H2 Haplotype b Generation N13F4+17 (31-DEC-08)

Appearance
black
Related Genotype: a/a

Important Note
The C57BL/6J background strain is homozygous for the age related hearing loss mutation Cdh23^ahl, which on this background causes progressive hearing loss with onset after 10 months of age.

Description
A chromosome substitution or consomic strain is an inbred strain with one of its chromosomes replaced by the homologous chromosome of another inbred strain. The C57BL/6J and A/J strains in this set were chosen because they differ in their susceptibility to diseases such as arthritis, asthma, atherosclerosis, cancer, several infectious diseases, inflammatory responses, and physiological, behavioral and sensory phenotypes. Chromosome substitution strain nomenclature is designated as Host Strain - Chromosome #<Donor Strain>/Laboratory code. For example, C57BL/6J-Chr1^A/NaJ carries chromosome 1 for strain A/J (A) on a C57BL/6J background, was constructed in the laboratory of Joseph Nadeau (Na) and is maintained at The Jackson Laboratory (J). Chromosome substitution strains or consomic strains can accelerate quantitative trait loci identification and mapping.

Development
Dr. Joseph Nadeau from Case Western Reserve University developed the C57BL/6J-Chr #^A/NaJ strain set by replacing individual chromosomes from the A/J donor strain into the C57BL/6J host strain using a marker-assisted series of backcrosses (Nadeau et al., 2000). The set was donated to The Jackson Laboratory in 2004.

Control Information

	Control
	000664 C57BL/6J
Considerations for Choosing Controls

Related Strains

B6/A Consomic Panel

004388	C57BL/6J-Chr 10A/J/NaJ
004389	C57BL/6J-Chr 11A/J/NaJ
004390	C57BL/6J-Chr 12A/J/NaJ
004392	C57BL/6J-Chr 14A/J/NaJ
004393	C57BL/6J-Chr 15A/J/NaJ
004394	C57BL/6J-Chr 16A/J/NaJ
004395	C57BL/6J-Chr 17A/J/NaJ
004396	C57BL/6J-Chr 18A/J/NaJ
004397	C57BL/6J-Chr 19A/J/NaJ
004379	C57BL/6J-Chr 1A/J/NaJ
004380	C57BL/6J-Chr 2A/J/NaJ
004381	C57BL/6J-Chr 3A/J/NaJ
004382	C57BL/6J-Chr 4A/J/NaJ
004383	C57BL/6J-Chr 5A/J/NaJ
004384	C57BL/6J-Chr 6A/J/NaJ
004385	C57BL/6J-Chr 7A/J/NaJ
004386	C57BL/6J-Chr 8A/J/NaJ
004387	C57BL/6J-Chr 9A/J/NaJ
004398	C57BL/6J-Chr XA/J/NaJ
004399	C57BL/6J-Chr YA/J/NaJ
005545	C57BL/6J-mtA/J/NaJ

View B6/A Consomic Panel     (21 strains)

Strains carrying   Cdh23^ahl allele

001137	129P1/ReJ
000690	129P3/J
000691	129X1/SvJ
000646	A/J
000647	A/WySnJ
003070	ALR/LtJ
003072	ALS/LtJ
004502	B6;AKR-Lxl2/GrsrJ
001026	BALB/cByJ
000653	BUB/BnJ
005494	C3.129S1(B6)-Grm1rcw/J
000664	C57BL/6J
004764	C57BL/6J-Cdh23v-8J/J
003129	C57BL/6J-Epha4rb-2J/GrsrJ
004820	C57BL/6J-Kcne12J/J
004703	C57BL/6J-Kcnq2Nmf134/J
004811	C57BL/6J-nmf110/J
004812	C57BL/6J-nmf111/J
004747	C57BL/6J-nmf118/J
004656	C57BL/6J-nmf88/J
004385	C57BL/6J-Chr 7A/J/NaJ
000662	C57BLKS/J
000667	C57BR/cdJ
000668	C57L/J
000669	C58/J
000657	CE/J
000670	DBA/1J
001140	DBA/1LacJ
000671	DBA/2J
007048	DBA/2J-Gpnmb+/SjJ
002106	KK/HlJ
000675	LG/J
000676	LP/J
000677	MA/MyJ
001976	NOD/ShiLtJ
002050	NOR/LtJ
000679	P/J
002747	SENCARB/PtJ
002335	SKH2/J
003392	STOCK Crb1rd8/J

View Strains carrying   Cdh23^ahl     (40 strains)

Strains carrying other alleles of Cdh23

002756	B6.CAST-Cdh23Ahl+/Kjn
002432	B6J x B6.C-H2-Kbm1/ByJ-Cdh23v-J/J
002552	C57BL/6J-Cdh23v-2J/J
004764	C57BL/6J-Cdh23v-8J/J
004819	C57BL/6J-Cdh23v-9J/J
005016	CByJ;B6-Cdh23v-10J/J
000275	V/LeJ

View Strains carrying other alleles of Cdh23     (7 strains)

Additional Web Information

Genetic Quality Control Annual Report
JAX^® NOTES, Spring 2004; 493. Chromosome Substitution Strain Panel: A New Tool for Quantitative Trait Loci Analysis.

Phenotype

Phenotype Information

View Phenotypic Data

Phenotypic Data

Mouse Phenome Database

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Research Tools
Genetics Research
      Gene Mapping: Tools for QTL Mapping, Segregation and Linkage Analysis

Cdh23^ahl related

Neurobiology Research
Vestibular and Hearing Defects
      Age related hearing loss

Sensorineural Research
Vestibular and Hearing Defects
      Age related hearing loss

Genes & Alleles

Gene & Allele Information

Allele Symbol		Cdh23ahl
Allele Name		age related hearing loss 1
Allele Type		QTL
Common Name(s)		Cdh23753A; mdfw;

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Genotyping resources and troubleshooting

References

References

Selected Reference(s)

Nadeau JH; Singer JB; Matin A; Lander ES. 2000. Analysing complex genetic traits with chromosome substitution strains. Nat Genet 24(3):221-5. [PubMed: 10700173]  [MGI Ref ID J:60756]

Additional References

Singer JB; Hill AE; Burrage LC; Olszens KR; Song J; Justice M; O'Brien WE; Conti DV; Witte JS; Lander ES; Nadeau JH. 2004. Genetic dissection of complex traits with chromosome substitution strains of mice. Science 304(5669):445-8. [PubMed: 15031436]  [MGI Ref ID J:90105]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           FGB27

Colony Maintenance

Mating System	Sibling x Sibling         (Female x Male)   01-MAR-06
Diet Information	LabDiet® 5K52/5K67

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Supply Details

Standard Supply	Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement.
Supply Notes	Usually shipped between four and eight weeks of age. This strain is included in the Special Mutant Stock Resource collection. Genomic DNA is available for this strain from the Mouse DNA Resource.
Important Note
The C57BL/6J background strain is homozygous for the age related hearing loss mutation Cdh23ahl, which on this background causes progressive hearing loss with onset after 10 months of age.

Control Information

	Control
	000664 C57BL/6J
Considerations for Choosing Controls
USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
International - Control Pricing Information for Genetically Engineered Mutant Strains.

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See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Ordering and Purchasing Information

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Technical Support Email Form

Terms of Use

Terms of Use

General Terms and Conditions

For Licensing and Use Restrictions view the link(s) below:
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Contact information

General inquiries

Contracts Administration

phone:	207-288-6470
fax:	207-288-6655

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