JAX Mice Database - 004391 C57BL/6J-Chr 13<A/J>/NaJ

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Strain Name:	C57BL/6J-Chr 13^A/J/NaJ
Stock Number:	004391
Availability:	Repository- Live

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Former Name	C57BL/6J-Chr 13^A/NaJ (Changed: 19-SEP-06 )
	C57BL/6J-13^A/Na (Changed: 15-DEC-04 )
Genes & Alleles	Cdh23; Cdh23^ahl;

Product Information

Strain Details

Type Consomic

Additional information on Consomic Mice.

Mating System Sibling x Sibling (Female x Male)

Species laboratory mouse

Background Strain C57BL/6J

Donor Strain A/J

H2 Haplotype b

Generation N13F4+12 (23-OCT-07)

Appearance
black
Related Genotype: a/a
Important Note
The C57BL/6J background strain is homozygous for the age related hearing loss mutation Cdh23^ahl, which on this background causes progressive hearing loss with onset after 10 months of age.
Strain Description
A chromosome substitution or consomic strain is an inbred strain with one of its chromosomes replaced by the homologous chromosome of another inbred strain. The C57BL/6J and A/J strains in this set were chosen because they differ in their susceptibility to diseases such as arthritis, asthma, atherosclerosis, cancer, several infectious diseases, inflammatory responses, and physiological, behavioral and sensory phenotypes. Chromosome substitution strain nomenclature is designated as Host Strain - Chromosome #<Donor Strain>/Laboratory code. For example, C57BL/6J-Chr1^A/NaJ carries chromosome 1 for strain A/J (A) on a C57BL/6J background, was constructed in the laboratory of Joseph Nadeau (Na) and is maintained at The Jackson Laboratory (J). Chromosome substitution strains or consomic strains can accelerate quantitative trait loci identification and mapping.
Strain Development
Dr. Joseph Nadeau from Case Western Reserve University developed the C57BL/6J-Chr #^A/NaJ strain set by replacing individual chromosomes from the A/J donor strain into the C57BL/6J host strain using a marker-assisted series of backcrosses (Nadeau et al., 2000). The set was donated to The Jackson Laboratory in 2004.

Gene & Allele Details

Allele Symbol		Cdh23^ahl
Allele Name		age related hearing loss 1
Common Name(s)		Cdh23^753A; mdfw;

Control Information

	Control
	000664 C57BL/6J

Considerations for Choosing Controls

Colony Maintenance

Diet Information	LabDiet® 5K52/5K67

Related Strains

B6/A Consomic Panel

004388 C57BL/6J-Chr 10^A/J/NaJ

004389 C57BL/6J-Chr 11^A/J/NaJ

004390 C57BL/6J-Chr 12^A/J/NaJ

004392 C57BL/6J-Chr 14^A/J/NaJ

004393 C57BL/6J-Chr 15^A/J/NaJ

004394 C57BL/6J-Chr 16^A/J/NaJ

004395 C57BL/6J-Chr 17^A/J/NaJ

004396 C57BL/6J-Chr 18^A/J/NaJ

004397 C57BL/6J-Chr 19^A/J/NaJ

004379 C57BL/6J-Chr 1^A/J/NaJ

004380 C57BL/6J-Chr 2^A/J/NaJ

004381 C57BL/6J-Chr 3^A/J/NaJ

004382 C57BL/6J-Chr 4^A/J/NaJ

004383 C57BL/6J-Chr 5^A/J/NaJ

004384 C57BL/6J-Chr 6^A/J/NaJ

004385 C57BL/6J-Chr 7^A/J/NaJ

004386 C57BL/6J-Chr 8^A/J/NaJ

004398 C57BL/6J-Chr X^A/J/NaJ

004399 C57BL/6J-Chr Y^A/J/NaJ

005545 C57BL/6J-mt^A/J/NaJ

View B6/A Consomic Panel (20 strains)

Strains carrying Cdh23^ahl allele

001137 129P1/ReJ

000690 129P3/J

002065 129T2/SvEmsJ

000691 129X1/SvJ

000646 A/J

000647 A/WySnJ

003070 ALR/LtJ

003072 ALS/LtJ

004502 B6;AKR-Lxl2/J

001026 BALB/cByJ

000653 BUB/BnJ

005494 C3.129S1(B6)-Grm1^rcw/J

000664 C57BL/6J

004764 C57BL/6J-Cdh23^v-8J/J

003129 C57BL/6J-Epha4^rb-2J/J

004820 C57BL/6J-Kcne1^2J/J

004703 C57BL/6J-Nmf134/J

004811 C57BL/6J-nmf110/J

004812 C57BL/6J-nmf111/J

004747 C57BL/6J-nmf118/J

004656 C57BL/6J-nmf88/J

004385 C57BL/6J-Chr 7^A/J/NaJ

000662 C57BLKS/J

000667 C57BR/cdJ

000668 C57L/J

000669 C58/J

000657 CE/J

000670 DBA/1J

001140 DBA/1LacJ

000671 DBA/2J

007048 DBA/2J-Gpnmb⁺/SjJ

002106 KK/HlJ

000675 LG/J

000676 LP/J

000677 MA/MyJ

001976 NOD/ShiLtJ

002050 NOR/LtJ

000679 P/J

002747 SENCARB/PtJ

002335 SKH2/J

003392 STOCK Crb1^rd8/J

View Strains carrying Cdh23^ahl (41 strains)

Strains carrying other alleles of Cdh23

002756 B6.CAST-Cdh23^Ahl+/Kjn

002432 B6J x B6.C-H2^bm1/ByJ-Cdh23^v-J/J

002552 C57BL/6J-Cdh23^v-2J/J

004764 C57BL/6J-Cdh23^v-8J/J

004819 C57BL/6J-Cdh23^v-9J/J

005016 CByJ;B6-Cdh23^v-10J/J

000275 V/LeJ

View Strains carrying other alleles of Cdh23 (7 strains)

Phenotypic Data

Mouse Phenome Database

Additional Web Information

Genetic Quality Control Annual Report
JAX Notes, Spring 2004; 493. Chromosome Substitution Strain Panel: A New Tool for Quantitative Trait Loci Analysis.

Animal Health Reports

Room Number FGB27

Research Applications

This mouse can be used to support research in many areas including:

Research Tools
Genetics Research (Gene Mapping: Tools for QTL Mapping, Segregation and Linkage Analysis)

Cdh23^ahl related

Neurobiology Research
Vestibular and Hearing Defects (Age related hearing loss)

Sensorineural Research
Vestibular and Hearing Defects (Age related hearing loss)

References

Selected Reference(s)

Nadeau JH; Singer JB; Matin A; Lander ES. 2000. Analysing complex genetic traits with chromosome substitution strains. Nat Genet 24(3):221-5. [PubMed: 10700173] [J:60756]

Additional References

Price and Supply Information

Strain Name:	C57BL/6J-Chr 13^A/J/NaJ
Stock Number:	004391

Price Details

IMPORTANT NOTE: Prices are based on shipping destination. To view prices, select your shipping destination.

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Supply Details

Standard Supply	Repository-Live. No age specifications accepted. Colony sized to produce minimal quantities (typically up to 6 mice) upon order receipt; one order per strain. Expected delivery: 1-3 months. Larger quantities or custom orders arranged upon request.
Supply Notes	Usually shipped between four and eight weeks of age. This strain is included in the Special Mutant Stock Resource collection. Genomic DNA is available for this strain from the Mouse DNA Resource.
Licensing	See General Terms and Conditions below for Licensing and Use Restrictions
Control Information	View Control Information in Strain Details.

General Terms and Conditions

View JAX^® Mice & Services Conditions of Use.

For additional Licensing and Use Restrictions view the link(s) below:
- Sale of Consomic Strains to Companies requires a license from Case Western Reserve University prior to shipping.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

Ordering and Purchasing Information

Purchasing Information
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Surgical Services

Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form

Go to JAX^® Mice Query Form

004388	C57BL/6J-Chr 10^A/J/NaJ
004389	C57BL/6J-Chr 11^A/J/NaJ
004390	C57BL/6J-Chr 12^A/J/NaJ
004392	C57BL/6J-Chr 14^A/J/NaJ
004393	C57BL/6J-Chr 15^A/J/NaJ
004394	C57BL/6J-Chr 16^A/J/NaJ
004395	C57BL/6J-Chr 17^A/J/NaJ
004396	C57BL/6J-Chr 18^A/J/NaJ
004397	C57BL/6J-Chr 19^A/J/NaJ
004379	C57BL/6J-Chr 1^A/J/NaJ
004380	C57BL/6J-Chr 2^A/J/NaJ
004381	C57BL/6J-Chr 3^A/J/NaJ
004382	C57BL/6J-Chr 4^A/J/NaJ
004383	C57BL/6J-Chr 5^A/J/NaJ
004384	C57BL/6J-Chr 6^A/J/NaJ
004385	C57BL/6J-Chr 7^A/J/NaJ
004386	C57BL/6J-Chr 8^A/J/NaJ
004398	C57BL/6J-Chr X^A/J/NaJ
004399	C57BL/6J-Chr Y^A/J/NaJ
005545	C57BL/6J-mt^A/J/NaJ

001137	129P1/ReJ
000690	129P3/J
002065	129T2/SvEmsJ
000691	129X1/SvJ
000646	A/J
000647	A/WySnJ
003070	ALR/LtJ
003072	ALS/LtJ
004502	B6;AKR-Lxl2/J
001026	BALB/cByJ
000653	BUB/BnJ
005494	C3.129S1(B6)-Grm1^rcw/J
000664	C57BL/6J
004764	C57BL/6J-Cdh23^v-8J/J
003129	C57BL/6J-Epha4^rb-2J/J
004820	C57BL/6J-Kcne1^2J/J
004703	C57BL/6J-Nmf134/J
004811	C57BL/6J-nmf110/J
004812	C57BL/6J-nmf111/J
004747	C57BL/6J-nmf118/J
004656	C57BL/6J-nmf88/J
004385	C57BL/6J-Chr 7^A/J/NaJ
000662	C57BLKS/J
000667	C57BR/cdJ
000668	C57L/J
000669	C58/J
000657	CE/J
000670	DBA/1J
001140	DBA/1LacJ
000671	DBA/2J
007048	DBA/2J-Gpnmb⁺/SjJ
002106	KK/HlJ
000675	LG/J
000676	LP/J
000677	MA/MyJ
001976	NOD/ShiLtJ
002050	NOR/LtJ
000679	P/J
002747	SENCARB/PtJ
002335	SKH2/J
003392	STOCK Crb1^rd8/J

002756	B6.CAST-Cdh23^Ahl+/Kjn
002432	B6J x B6.C-H2^bm1/ByJ-Cdh23^v-J/J
002552	C57BL/6J-Cdh23^v-2J/J
004764	C57BL/6J-Cdh23^v-8J/J
004819	C57BL/6J-Cdh23^v-9J/J
005016	CByJ;B6-Cdh23^v-10J/J
000275	V/LeJ

Strain Name:

C57BL/6J-Chr 13A/J/NaJ

Stock Number:

004391

Availability:

Repository- Live

General Terms and Conditions

Product Information

Strain Details

Gene & Allele Details

Control Information

Colony Maintenance

Related Strains

Phenotypic Data

Additional Web Information

Animal Health Reports

Research Applications

References

Price and Supply Information

Price Details

*NO Shipping Destination selected!

Supply Details

General Terms and Conditions

The Jackson Laboratory's Genotype Promise

C57BL/6J-Chr 13^A/J/NaJ