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Strain Name:

C3HeB/FeJ-Pou3f4del-J/J

Stock Number:

004406

Availability:

Repository- Live

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General Terms and Conditions

Genes & Alleles   Pou3f4;   Pou3f4del-J;

Product Information

Strain Details

Type Deletion
Additional information on Mice with Chromosomal Aberrations.
Type JAX® GEMM® Strain - Mutant Strain
Additional information on JAX® GEMM® Strains.
Type JAX® GEMM® Strain - Spontaneous Mutation
Specieslaboratory mouse
H2 Haplotypek
Generation?+N2F4 (06-DEC-07)

Appearance
agouti, circling male
Related Genotype: A/A Pou3f4del-J/Y

agouti, unaffected male
Related Genotype: A/A +/Y

agouti, unaffected female
Related Genotype: A/A Pou3f4del-J/Pou3f4del-J or Pou3f4del-J/+

Related Disease (OMIM) Terms

Deafness, X-Linked 2; DFNX2
Mammalian Phenotype Terms assigned by genotype

Pou3f4del-J/Pou3f4+

        C3HeB/FeJ-Pou3f4del-J/J
  • hearing/vestibular/ear phenotype
  • absent linear vestibular evoked potential (MGI Ref ID J:116914)
    • in one of two mice tested, VESPs are absent at the maximum stimulus intensity used

Pou3f4del-J/Pou3f4del-J

        C3HeB/FeJ-Pou3f4del-J/J
  • behavior/neurological phenotype
  • circling (MGI Ref ID J:83049)
  • head bobbing (MGI Ref ID J:116914)
  • hearing/vestibular/ear phenotype
  • absent linear vestibular evoked potential (MGI Ref ID J:116914)
    • VESPs are absent at the maximum stimulus intensity used
  • circling (MGI Ref ID J:83049)
  • head bobbing (MGI Ref ID J:116914)
  • impaired hearing (MGI Ref ID J:83049)
    • hearing is impaired

Pou3f4del-J/Y

        C3HeB/FeJ-Pou3f4del-J/J
  • behavior/neurological phenotype
  • circling (MGI Ref ID J:83049)
  • head bobbing (MGI Ref ID J:116914)
  • hearing/vestibular/ear phenotype
  • absent linear vestibular evoked potential (MGI Ref ID J:116914)
    • VESPs are absent at the maximum stimulus intensity used
  • circling (MGI Ref ID J:83049)
  • head bobbing (MGI Ref ID J:116914)
  • impaired hearing (MGI Ref ID J:83049)
    • hearing is impaired

Gene & Allele Details

Allele Symbol Pou3f4del-J
Allele Name deletion, Jackson
Strain of OriginC3HeB/FeJ
Gene Symbol and Name Pou3f4, POU domain, class 3, transcription factor 4
Chromosome X
Gene Common Name(s) BRAIN-4; BRN-4; BRN4; Brn-4; DFN3; DFNX2; OTF9; Otf9; RHS2; Slf; octamer binding transcription factor 9; sex linked fidget;
Molecular Note Polymerase chain reaction analysis revealed that the Pou3f4 gene is deleted in its entirety; the full extent of the deletion is not yet known. [MGI Ref ID J:83049]

Control Information

  Allele   Control
 Pou3f4del-J  Untested (+/?) Female
 Pou3f4del-J  Wild-type (+/Y) Male
 
  Considerations for Choosing Controls

Related Strains

View Deletion     (6 strains)

Animal Health Reports

Room Number           A1

Research Applications

This mouse can be used to support research in many areas including:

Pou3f4del-J related

Mouse/Human Gene Homologs
deafness, neurosensory, autosomal recessive, 3

Neurobiology Research
Vestibular and Hearing Defects (deafness, neurosensory 3)

Sensorineural Research
Vestibular and Hearing Defects (deafness, neurosensory 3)

References

Additional References

Price and Supply Information

Strain Name: C3HeB/FeJ-Pou3f4del-J/J
Stock Number: 004406

Price Details

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Supply Details

Standard SupplyRepository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.
Supply Notes Usually shipped between four and eight weeks of age.
This strain is included in the Mouse Mutant Resource collection.
Genomic DNA is available for this strain from the Mouse DNA Resource.
LicensingSee General Terms and Conditions below  
Control InformationView Control Information in Strain Details.

General Terms and Conditions

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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