Strain Name:

DBA/1LacJ-Lrp4mdig/GrsrJ

Stock Number:

004423

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Availability:

Cryopreserved - Ready for recovery

Other products are available, see Purchasing Information for Cryopreserved Embryos

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names DBA/1LacJ-Lrp4mdig/J    (Changed: 22-JUN-09 )
DBA/1LacJ-mdig/J    (Changed: 01-JUN-06 )
Type Coisogenic; Mutant Strain; Spontaneous Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse
H2 Haplotypeq
GenerationF60+13+N1p (11-SEP-05)
Generation Definitions

Appearance
dilute brown, malformed digits
Related Genotype: a/a Tyrp1b/Tyrp1b Myo5ad/Myo5ad mdig/mdig

dilute brown, unaffected
Related Genotype: a/a Tyrp1b/Tyrp1b Myo5ad/Myo5ad mdig/+

Description
Homozygotes have variable brachydactyly and syndactyly of all four feet and incomplete polydactyly can occur in the front feet.

Development
The recessive mdig mutation arose spontaneously in 1999 on the DBA/1LacJ background at The Jackson Laboratory and has been maintained primarily through sibling mating homozygote x heterozygote and vice versa. In 2005 embryos were generated for cryopreservation from DBA/1LacJ females and homozygous mutant males.

Control Information

  Control
   Heterozygote
 
  Considerations for Choosing Controls

Related Strains

View Facebase: spontaneous mutations     (25 strains)

Strains carrying other alleles of Lrp4
013157   B6;129S6-Lrp4tm1Her/J
010968   SB;C3Sn-Lrp4mdig-2J/GrsrJ
View Strains carrying other alleles of Lrp4     (2 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Cenani-Lenz Syndactyly Syndrome; CLSS   (LRP4)
Sclerosteosis 2; SOST2   (LRP4)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Lrp4mdig/Lrp4mdig

        DBA/1LacJ-Lrp4mdig/GrsrJ
  • limbs/digits/tail phenotype
  • brachydactyly
    • digits are malformed on all 4 feet, some exhibiting brachydactyly, some syndactyly   (MGI Ref ID J:83757)
  • syndactyly
    • digits are malformed on all 4 feet, some exhibiting brachydactyly, some syndactyly   (MGI Ref ID J:83757)

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Lrp4mdig/Lrp4mdig

        involves: 129S2/SvPas * DBA/1LacJ
  • limbs/digits/tail phenotype
  • brachydactyly
    • variable brachydactyly seen on all four limbs   (MGI Ref ID J:108168)
  • polydactyly
    • duplication of digits along the dorsoventral axis   (MGI Ref ID J:108168)
    • polysyndactyly   (MGI Ref ID J:108168)
  • syndactyly
    • variable syndactyly seen on all four limbs   (MGI Ref ID J:108168)
    • typically involves fusion of 2 or 3 adjacent segments along the anteroposterior axis   (MGI Ref ID J:108168)
    • polysyndactyly   (MGI Ref ID J:108168)
  • behavior/neurological phenotype
  • abnormal nursing
    • females and males are fertile but females sometimes fail to nurse their pups   (MGI Ref ID J:108168)
  • craniofacial phenotype
  • *normal* craniofacial phenotype
    • no tooth abnormalities are seen   (MGI Ref ID J:108168)
  • integument phenotype
  • deformed nails
    • nails are often abnormally shaped or placed but are never fused   (MGI Ref ID J:108168)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Lrp4mdig related

Developmental Biology Research
Skeletal Defects
      Oligodactyly
      brachydactyly
      syndactyly

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Lrp4mdig
Allele Name malformed digits
Allele Type Spontaneous
Strain of OriginDBA/1LacJ
Gene Symbol and Name Lrp4, low density lipoprotein receptor-related protein 4
Chromosome 2
Gene Common Name(s) 6430526J12Rik; CLSS; LRP-4; LRP10; MEGF7; RIKEN cDNA 6430526J12 gene; SOST2; malformed digits; mdig;
Molecular Note An A to T transversion at the 3' end of exon 15 results in a mutant splice site. As a consequence, exon 15 is skipped. [MGI Ref ID J:108168]

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Cook SA; Bronson RT; Davisson MT. 2003. A new mutation, mdig, in the Fnbp4-Alx4-Ext2 region of mouse Chromosome 2. Mouse Mutant Resources Web Site, The Jackson Laboratory, Bar Harbor, Maine MGI Direct Data Submission :.  [MGI Ref ID J:83757]

Simon-Chazottes D; Tutois S; Kuehn M; Evans M; Bourgade F; Cook S; Davisson MT; Guenet JL. 2006. Mutations in the gene encoding the low-density lipoprotein receptor LRP4 cause abnormal limb development in the mouse. Genomics 87(5):673-7. [PubMed: 16517118]  [MGI Ref ID J:108168]

Additional References

Lrp4mdig related

Ahn Y; Sims C; Logue JM; Weatherbee SD; Krumlauf R. 2013. Lrp4 and Wise interplay controls the formation and patterning of mammary and other skin appendage placodes by modulating Wnt signaling. Development 140(3):583-93. [PubMed: 23293290]  [MGI Ref ID J:194074]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2450.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Embryos

Price (US dollars $)
Frozen Embryo $1600.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.

  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3185.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Embryos

Price (US dollars $)
Frozen Embryo $2080.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.

  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

General Supply Notes

  • View the complete collection of spontaneous mutants in the Mouse Mutant Resource.
  • Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

  Control
   Heterozygote
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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