Strain Name:

C.129S6-Tbx21tm1Glm/J

Stock Number:

004432

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This Tbx21 (or T-bet) knock-out mutant mouse strain represents a model that may be useful in studies of acute and chronic human asthma, chronic intestinal inflammation, metabolic physiology and obesity-associated insulin resistance.

Description

Strain Information

Former Names B6.129S6-Tbx21tm1Glm    (Changed: 15-DEC-04 )
T-bet KO    (Changed: 15-DEC-04 )
Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Mating SystemHomozygote x Homozygote         (Female x Male)   05-APR-13
Specieslaboratory mouse
GenerationN?+F2 (11-DEC-13)
Generation Definitions
 
Donating InvestigatorDr. Laurie H. Glimcher,   Weill Cornell Medical College

Description
The Tbx21 gene encodes a transcription factor that controls expression of interferon-gamma and is involved in Th1 cell lineage development. Mice that are homozygous for this targeted mutation of Tbx21, in which a NEO cassette replaces 2 Kb of sequence (exon 1 and flanking sequence), are viable and fertile. No gene product (mRNA or protein) is detected in isolated lymph node T-cells by Northern or Western blot analysis. T cells from the homozygotes do not produce the TH1 type cytokine, interferon-gamma, and secrete elevated levels of TH2 type cytokines in vitro to TCR cross-linking and in vivo to protein antigen immunization. Additionally, mice homozygous for the targeted mutation on the BALB/c genetic background are susceptible to Leishmania major infections. Without induced sensitization or challenge, female homozygotes display airway hyper responsiveness (AHR) with resulting airway remodeling similar to characteristics of asthma. Histological analysis of lung from female homozygous mice, aged 4 to 6 weeks, reveals eosinophil and lymphocyte infiltration of peribronchial and perivenular tissue, thickening of the subepithelial collagen layer, and increased numbers of myofibroblast cells in bronchial tissue. Bronchial alveolar lavage fluid contains elevated levels of TGF-beta1, TNF-alpha, IL-4 and IL-13. Mice heterozygous for the targeted mutation display an intermediate phenotype. Homozygous male mice, at 8 weeks to 28 weeks of age, weigh more than wildtype controls. Although food intake on a low fat diet was similar for all genotypes, homozygous mice exhibit a lower food intake on a high fat diet compare to wildtype controls. Homozygotes also display increased intra-abdominal or visceral adipose tissue mass and increased adipocyte size when compared to controls. Homozygotes at 8 weeks and 6 months of age exhibit lower fasting and fed serum insulin levels, better glucose tolerance and enhanced insulin sensitivity than wildtype controls. Adipose tissue in homozygotes have fewer CD45+, CD4+, CD8+, and NK cells and reduced cytokine secretion.

Development
A targeting vector containing neomycin resistance and herpes simplex virus thymidine kinase genes was used to disrupt 2 Kb of sequence encoding exon 1 and flanking sequence. The construct was electroporated into 129S6/SvEvTac derived TC1 embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6 blastocysts. The resulting chimeric animals were crossed to BALB/c mice, and then backcrossed to BALB/c for 8 generations.

Control Information

  Control
   000651 BALB/cJ
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Tbx21tm1Glm allele
004648   B6.129S6-Tbx21tm1Glm/J
View Strains carrying   Tbx21tm1Glm     (1 strain)

Strains carrying other alleles of Tbx21
022741   B6.129-Tbx21tm2Srnr/J
024507   B6;CBA-Tg(Tbx21-cre)1Dlc/J
View Strains carrying other alleles of Tbx21     (2 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Model with phenotypic similarity to human disease where etiologies are distinct. Human genes are associated with this disease. Orthologs of these genes do not appear in the mouse genotype(s).
Asthma, Susceptibility to
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Asthma, Nasal Polyps, and Aspirin Intolerance   (TBX21)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Tbx21tm1Glm/Tbx21tm1Glm

        C.129S6-Tbx21tm1Glm/J
  • immune system phenotype
  • CNS inflammation
    • CNS of mutants show less infiltration of leukocytes into the spinal cord at 5 days after EAE onset (15 days); very little CD4+ T cell infiltration is seen compared to wild-type spinal cords   (MGI Ref ID J:111932)
  • abnormal CD4-positive, alpha-beta T cell physiology
    • primed splenocytes from deficient animals produce less interferon-gamma (Ifng) than wild-type cells, but produce much increased levels of Il-10 throughout the course of the disease compared to wild-type   (MGI Ref ID J:111932)
    • however, recall responses of in vivo primed splenocytes from mutants 10 days after immunization are comparable to wild-type as significant proliferation in response to PLP peptide is observed ex vivo   (MGI Ref ID J:111932)
  • abnormal cytokine secretion
    • wild-type mice show presence of Ifng in the spinal cord after disease development, while mutants show no Ifng but significant 1l-10 production   (MGI Ref ID J:111932)
  • decreased susceptibility to experimental autoimmune encephalomyelitis
    • when immunized with PLP (proteolipid protein) peptide 180-199, mutants are resistant to development of clinical experimental autoimmune encephalitis (EAE) disease while wild-type littermates develop a more severe form of disease   (MGI Ref ID J:111932)
    • Tbx21-deficient mice show a lower incidence of EAE over a period of 40 days vs wild-type controls   (MGI Ref ID J:111932)
    • mutants have a very mild clinical course of disease whereas wild-type show an earlier onset and develop a higher disease grade (2.5 vs 1.25)   (MGI Ref ID J:111932)
    • upon adoptive transfer of wild-type PLP-specific T cells, mutants show decreased EAE severity compared to wild-type   (MGI Ref ID J:111932)
  • nervous system phenotype
  • CNS inflammation
    • CNS of mutants show less infiltration of leukocytes into the spinal cord at 5 days after EAE onset (15 days); very little CD4+ T cell infiltration is seen compared to wild-type spinal cords   (MGI Ref ID J:111932)
  • hematopoietic system phenotype
  • abnormal CD4-positive, alpha-beta T cell physiology
    • primed splenocytes from deficient animals produce less interferon-gamma (Ifng) than wild-type cells, but produce much increased levels of Il-10 throughout the course of the disease compared to wild-type   (MGI Ref ID J:111932)
    • however, recall responses of in vivo primed splenocytes from mutants 10 days after immunization are comparable to wild-type as significant proliferation in response to PLP peptide is observed ex vivo   (MGI Ref ID J:111932)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Tbx21tm1Glm/Tbx21+

        involves: 129S6/SvEvTac * C57BL/6
  • hematopoietic system phenotype
  • abnormal NK cell physiology
    • splenic NK cells from mutants produce less Ifng in response to Il-12 or Il-18 than NK cells from wild-type   (MGI Ref ID J:73833)
  • decreased T helper 1 cell number
    • only 42% of CD4 T cells produce high levels of Ifng compared to wild-type   (MGI Ref ID J:73833)
  • immune system phenotype
  • abnormal NK cell physiology
    • splenic NK cells from mutants produce less Ifng in response to Il-12 or Il-18 than NK cells from wild-type   (MGI Ref ID J:73833)
  • abnormal cytokine level
    • increased amount of TGFb is found in bronchial alveolar lavage (BAL) fluid compared to wild-type   (MGI Ref ID J:73833)
    • abnormal interleukin level
      • increased amounts of Il-4 and Il-13 are found in BAL fluid; Il-5 levels are high in mutants and do not increase with allergen challenge as wild-type levels do   (MGI Ref ID J:73832)
    • abnormal tumor necrosis factor level
      • increased amount of TNFa is found in bronchial alveolar lavage (BAL) fluid compared to wild-type   (MGI Ref ID J:73832)
  • decreased T helper 1 cell number
    • only 42% of CD4 T cells produce high levels of Ifng compared to wild-type   (MGI Ref ID J:73833)
  • respiratory system phenotype
  • abnormal respiratory system morphology
    • mice show an increase in thickness of subbasement collagen layer of the airways, with an increased numbers of bronchial myofibroblast   (MGI Ref ID J:73832)
  • increased airway responsiveness
    • 4-5 week old homozygous mice exhibit airway hyperresponsiveness (AHR) to methacholine challenge, in the absence of prior immunologic sensitization; mice are more responsive without allergen challenge than wild-type mice following antigen challenge   (MGI Ref ID J:73832)
  • homeostasis/metabolism phenotype
  • abnormal cytokine level
    • increased amount of TGFb is found in bronchial alveolar lavage (BAL) fluid compared to wild-type   (MGI Ref ID J:73833)
    • abnormal interleukin level
      • increased amounts of Il-4 and Il-13 are found in BAL fluid; Il-5 levels are high in mutants and do not increase with allergen challenge as wild-type levels do   (MGI Ref ID J:73832)
    • abnormal tumor necrosis factor level
      • increased amount of TNFa is found in bronchial alveolar lavage (BAL) fluid compared to wild-type   (MGI Ref ID J:73832)

Tbx21tm1Glm/Tbx21tm1Glm

        involves: 129S6/SvEvTac * C57BL/6
  • hematopoietic system phenotype
  • abnormal CD8-positive, alpha-beta cytotoxic T cell morphology
    • mutants have normal numbers of Ifng-producing CD8 T cells; as well, unexpectedly, mutant CD8 T cells produce equivalent levels of Ifng to wild-type   (MGI Ref ID J:73833)
  • abnormal NK cell physiology
    • splenic NK cells from mutants produce less Ifng in response to Il-12 or Il-18 than NK cells from wild-type   (MGI Ref ID J:73833)
    • impaired natural killer cell mediated cytotoxicity
      • NK cells from mutants are impaired in ability to lyse YAC-1 cells compared to wild-type   (MGI Ref ID J:73833)
    • increased natural killer cell mediated cytotoxicity
      • NK cells from mutants treated with poly(I:C) for activation lyse tumor cell targets equivalently to wild-type NK cells   (MGI Ref ID J:73833)
  • abnormal T-helper 1 cell differentiation
    • differentiation of CD4 T cells into helper T cell subsets is impaired or altered; cells fail to differentiate into Th1 lineage and default to Th2 fate   (MGI Ref ID J:73833)
  • abnormal immunoglobulin level
    • normal mixed response to protein antigen immunization is altered; after TNP-KLH treatment mice produced decreased IgG2a and very slightly increased IgG1 compared to controls at day 12   (MGI Ref ID J:73833)
  • decreased T helper 1 cell number
    • number of Ifng producing cells (Th1) decreases while Th2 cells producing Il-4 and Il-5 increase in number   (MGI Ref ID J:73833)
  • increased T-helper 2 cell number
    • number of Ifng producing cells (Th1) decreases while Th2 cells producing Il-4 and Il-5 increase in number   (MGI Ref ID J:73833)
  • immune system phenotype
  • abnormal CD8-positive, alpha-beta cytotoxic T cell morphology
    • mutants have normal numbers of Ifng-producing CD8 T cells; as well, unexpectedly, mutant CD8 T cells produce equivalent levels of Ifng to wild-type   (MGI Ref ID J:73833)
  • abnormal NK cell physiology
    • splenic NK cells from mutants produce less Ifng in response to Il-12 or Il-18 than NK cells from wild-type   (MGI Ref ID J:73833)
    • impaired natural killer cell mediated cytotoxicity
      • NK cells from mutants are impaired in ability to lyse YAC-1 cells compared to wild-type   (MGI Ref ID J:73833)
    • increased natural killer cell mediated cytotoxicity
      • NK cells from mutants treated with poly(I:C) for activation lyse tumor cell targets equivalently to wild-type NK cells   (MGI Ref ID J:73833)
  • abnormal T-helper 1 cell differentiation
    • differentiation of CD4 T cells into helper T cell subsets is impaired or altered; cells fail to differentiate into Th1 lineage and default to Th2 fate   (MGI Ref ID J:73833)
  • abnormal cytokine level
    • increased amount of TGFb is found in bronchial alveolar lavage (BAL) fluid compared to wild-type   (MGI Ref ID J:73832)
    • abnormal interleukin level
      • increased amounts of Il-4 and Il-13 are found in BAL fluid; Il-5 levels are high in mutants and do not increase with allergen challenge as wild-type levels do   (MGI Ref ID J:73832)
    • abnormal tumor necrosis factor level
      • increased amount of TNFa is found in bronchial alveolar lavage (BAL) fluid compared to wild-type   (MGI Ref ID J:73832)
  • abnormal immunoglobulin level
    • normal mixed response to protein antigen immunization is altered; after TNP-KLH treatment mice produced decreased IgG2a and very slightly increased IgG1 compared to controls at day 12   (MGI Ref ID J:73833)
  • decreased T helper 1 cell number
    • number of Ifng producing cells (Th1) decreases while Th2 cells producing Il-4 and Il-5 increase in number   (MGI Ref ID J:73833)
  • decreased interferon-gamma secretion
    • anti-CD3 and -CD28 stimulated CD4 T cells from lymph nodes of mutants show marked decrease in Ifng (interferon-gamma) production compared to controls; in presence of Il-12, Ifng production is reduced as well   (MGI Ref ID J:73833)
  • increased T-helper 2 cell number
    • number of Ifng producing cells (Th1) decreases while Th2 cells producing Il-4 and Il-5 increase in number   (MGI Ref ID J:73833)
  • increased susceptibility to parasitic infection
    • mutants on C57BL/6 background produce less Ifng in response to L. major infection and fail to cure infection, similar to BALB/c (susceptible) controls, while C57BL/6 (resistant) controls cure infection   (MGI Ref ID J:73833)
  • respiratory system inflammation
    • homozygotes show peribronchial and perivenular infiltration with eosinophils and lymphocytes compared to wild-type littermates   (MGI Ref ID J:73832)
  • respiratory system phenotype
  • abnormal respiratory system morphology
    • mice show an increase in thickness of subbasement collagen layer of the airways, with an increased numbers of bronchial myofibroblast   (MGI Ref ID J:73832)
  • increased airway responsiveness
    • 4-5 week old homozygous mice exhibit airway hyperresponsiveness (AHR) to methacholine challenge, in the absence of prior immunologic sensitization; mice are more responsive without allergen challenge than wild-type mice following antigen challenge   (MGI Ref ID J:73832)
  • respiratory system inflammation
    • homozygotes show peribronchial and perivenular infiltration with eosinophils and lymphocytes compared to wild-type littermates   (MGI Ref ID J:73832)
  • homeostasis/metabolism phenotype
  • abnormal cytokine level
    • increased amount of TGFb is found in bronchial alveolar lavage (BAL) fluid compared to wild-type   (MGI Ref ID J:73832)
    • abnormal interleukin level
      • increased amounts of Il-4 and Il-13 are found in BAL fluid; Il-5 levels are high in mutants and do not increase with allergen challenge as wild-type levels do   (MGI Ref ID J:73832)
    • abnormal tumor necrosis factor level
      • increased amount of TNFa is found in bronchial alveolar lavage (BAL) fluid compared to wild-type   (MGI Ref ID J:73832)

Tbx21tm1Glm/Tbx21tm1Glm

        B6.129S6-Tbx21tm1Glm
  • immune system phenotype
  • abnormal CD4-positive T cell differentiation
    • wild-type CD4+ T cells polarized under Th17 conditions can be converted to a Th1-like cells (i.e. they express IFN-gamma) by culturing with IL-12   (MGI Ref ID J:143729)
    • mutant polarized Th17 CD4+ T cells fail to convert to the Th1-like state in the presence of IL-12   (MGI Ref ID J:143729)
  • hematopoietic system phenotype
  • abnormal CD4-positive T cell differentiation
    • wild-type CD4+ T cells polarized under Th17 conditions can be converted to a Th1-like cells (i.e. they express IFN-gamma) by culturing with IL-12   (MGI Ref ID J:143729)
    • mutant polarized Th17 CD4+ T cells fail to convert to the Th1-like state in the presence of IL-12   (MGI Ref ID J:143729)

Tbx21tm1Glm/Tbx21tm1Glm

        involves: 129S6/SvEvTac
  • immune system phenotype
  • abnormal cytokine level
    • T cells from mice immunized with myelin oligodendrocyte glycoprotein (MOG) peptide show more interferon gamma (Ifng) and Ifng-secreting cells than wild-type ; numbers of IL-17a producing cells as well as IL-17a levels are higher than in wild-type   (MGI Ref ID J:112600)
  • abnormal leukocyte migration
    • Th1 and Tc1 show a modest decrease in migration to CXCL10   (MGI Ref ID J:163822)
  • decreased CD4-positive, alpha beta T cell number   (MGI Ref ID J:163822)
  • decreased memory T cell number
  • increased interleukin-17 secretion
    • when CD8+ T cells are cultured in Th17-polarizing conditions 2-3 fold more IL17 producing cells are produced   (MGI Ref ID J:163822)
  • increased susceptibility to induced colitis
    • DSS-treated mice develop more extensive and severe inflammatory infiltrate, edema, extensive ulceration, and crypt loss compared with similarly treated wild-type mice   (MGI Ref ID J:141481)
  • homeostasis/metabolism phenotype
  • abnormal cytokine level
    • T cells from mice immunized with myelin oligodendrocyte glycoprotein (MOG) peptide show more interferon gamma (Ifng) and Ifng-secreting cells than wild-type ; numbers of IL-17a producing cells as well as IL-17a levels are higher than in wild-type   (MGI Ref ID J:112600)
  • digestive/alimentary phenotype
  • increased susceptibility to induced colitis
    • DSS-treated mice develop more extensive and severe inflammatory infiltrate, edema, extensive ulceration, and crypt loss compared with similarly treated wild-type mice   (MGI Ref ID J:141481)
  • hematopoietic system phenotype
  • abnormal leukocyte migration
    • Th1 and Tc1 show a modest decrease in migration to CXCL10   (MGI Ref ID J:163822)
  • decreased CD4-positive, alpha beta T cell number   (MGI Ref ID J:163822)
  • decreased memory T cell number
  • cellular phenotype
  • abnormal leukocyte migration
    • Th1 and Tc1 show a modest decrease in migration to CXCL10   (MGI Ref ID J:163822)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Tbx21tm1Glm related

Immunology, Inflammation and Autoimmunity Research
Immunodeficiency
      Asthma
Inflammation
      Asthma

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Tbx21tm1Glm
Allele Name targeted mutation 1, Laurie H Glimcher
Allele Type Targeted (Null/Knockout)
Common Name(s) T-bet-; Tbx21-;
Mutation Made ByDr. Laurie Glimcher,   Weill Cornell Medical College
Strain of Origin129S6/SvEvTac
ES Cell Line NameTC1/TC-1
ES Cell Line Strain129S6/SvEvTac
Gene Symbol and Name Tbx21, T-box 21
Chromosome 11
Gene Common Name(s) T-PET; T-bet; TBET; TBLYM; TBT1;
General Note Phenotypic Similarity to Human Syndrome: Susceptibility to Spontaneous Ulcerative Colitis (Rag2tm1Fwa Tbx21tm1Glm double homozygotes J:141481)
Molecular Note A neomycin selection cassette was used to replace a 2 kb region containing exon 1 and its flanking sequence. An absence of mRNA and protein were observed in T cells isolated from the lymph nodes of homozygous mutant mice by Northern blot and Western blotanalysis, respectively. [MGI Ref ID J:73833] [MGI Ref ID J:96620]

Genotyping

Genotyping Information

Genotyping Protocols

Tbx21tm1Glm, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Finotto S; Neurath MF; Glickman JN; Qin S; Lehr HA; Green FH; Ackerman K; Haley K; Galle PR; Szabo SJ; Drazen JM; De Sanctis GT; Glimcher LH. 2002. Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science 295(5553):336-8. [PubMed: 11786643]  [MGI Ref ID J:73832]

Additional References

Szabo SJ; Sullivan BM; Stemmann C; Satoskar AR; Sleckman BP; Glimcher LH. 2002. Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science 295(5553):338-42. [PubMed: 11786644]  [MGI Ref ID J:73833]

Tbx21tm1Glm related

Afshar-Sterle S; Zotos D; Bernard NJ; Scherger AK; Rodling L; Alsop AE; Walker J; Masson F; Belz GT; Corcoran LM; O'Reilly LA; Strasser A; Smyth MJ; Johnstone R; Tarlinton DM; Nutt SL; Kallies A. 2014. Fas ligand-mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas. Nat Med 20(3):283-90. [PubMed: 24487434]  [MGI Ref ID J:208773]

Albrecht I; Niesner U; Janke M; Menning A; Loddenkemper C; Kuhl AA; Lepenies I; Lexberg MH; Westendorf K; Hradilkova K; Grun J; Hamann A; Epstein JA; Chang HD; Tokoyoda K; Radbruch A. 2010. Persistence of effector memory Th1 cells is regulated by Hopx. Eur J Immunol 40(11):2993-3006. [PubMed: 21061432]  [MGI Ref ID J:167626]

Alcaide P; Jones TG; Lord GM; Glimcher LH; Hallgren J; Arinobu Y; Akashi K; Paterson AM; Gurish MA; Luscinskas FW. 2007. Dendritic cell expression of the transcription factor T-bet regulates mast cell progenitor homing to mucosal tissue. J Exp Med 204(2):431-9. [PubMed: 17296784]  [MGI Ref ID J:125370]

Aliprantis AO; Wang J; Fathman JW; Lemaire R; Dorfman DM; Lafyatis R; Glimcher LH. 2007. Transcription factor T-bet regulates skin sclerosis through its function in innate immunity and via IL-13. Proc Natl Acad Sci U S A 104(8):2827-30. [PubMed: 17307869]  [MGI Ref ID J:125909]

Anderson AC; Lord GM; Dardalhon V; Lee DH; Sabatos-Peyton CA; Glimcher LH; Kuchroo VK. 2010. T-bet, a Th1 transcription factor regulates the expression of Tim-3. Eur J Immunol 40(3):859-66. [PubMed: 20049876]  [MGI Ref ID J:157872]

Ariga H; Shimohakamada Y; Nakada M; Tokunaga T; Kikuchi T; Kariyone A; Tamura T; Takatsu K. 2007. Instruction of naive CD4+ T-cell fate to T-bet expression and T helper 1 development: roles of T-cell receptor-mediated signals. Immunology 122(2):210-21. [PubMed: 17490433]  [MGI Ref ID J:125688]

Bailis W; Yashiro-Ohtani Y; Fang TC; Hatton RD; Weaver CT; Artis D; Pear WS. 2013. Notch simultaneously orchestrates multiple helper T cell programs independently of cytokine signals. Immunity 39(1):148-59. [PubMed: 23890069]  [MGI Ref ID J:208238]

Bakshi CS; Malik M; Carrico PM; Sellati TJ. 2006. T-bet deficiency facilitates airway colonization by Mycoplasma pulmonis in a murine model of asthma. J Immunol 177(3):1786-95. [PubMed: 16849489]  [MGI Ref ID J:137975]

Balasubramani A; Shibata Y; Crawford GE; Baldwin AS; Hatton RD; Weaver CT. 2010. Modular utilization of distal cis-regulatory elements controls Ifng gene expression in T cells activated by distinct stimuli. Immunity 33(1):35-47. [PubMed: 20643337]  [MGI Ref ID J:162632]

Basu R; O'Quinn DB; Silberger DJ; Schoeb TR; Fouser L; Ouyang W; Hatton RD; Weaver CT. 2012. Th22 Cells Are an Important Source of IL-22 for Host Protection against Enteropathogenic Bacteria. Immunity 37(6):1061-75. [PubMed: 23200827]  [MGI Ref ID J:191059]

Buono C; Binder CJ; Stavrakis G; Witztum JL; Glimcher LH; Lichtman AH. 2005. T-bet deficiency reduces atherosclerosis and alters plaque antigen-specific immune responses. Proc Natl Acad Sci U S A 102(5):1596-601. [PubMed: 15665085]  [MGI Ref ID J:96110]

Burrell BE; Csencsits K; Lu G; Grabauskiene S; Bishop DK. 2008. CD8+ Th17 mediate costimulation blockade-resistant allograft rejection in T-bet-deficient mice. J Immunol 181(6):3906-14. [PubMed: 18768845]  [MGI Ref ID J:139106]

Caretto D; Katzman SD; Villarino AV; Gallo E; Abbas AK. 2010. Cutting edge: the Th1 response inhibits the generation of peripheral regulatory T cells. J Immunol 184(1):30-4. [PubMed: 19949064]  [MGI Ref ID J:159046]

Chang YJ; Kim HY; Albacker LA; Lee HH; Baumgarth N; Akira S; Savage PB; Endo S; Yamamura T; Maaskant J; Kitano N; Singh A; Bhatt A; Besra GS; van den Elzen P; Appelmelk B; Franck RW; Chen G; DeKruyff RH; Shimamura M; Illarionov P; Umetsu DT. 2011. Influenza infection in suckling mice expands an NKT cell subset that protects against airway hyperreactivity. J Clin Invest 121(1):57-69. [PubMed: 21157038]  [MGI Ref ID J:171843]

Chen A; Lee SM; Gao B; Shannon S; Zhu Z; Fang D. 2011. c-Abl-Mediated Tyrosine Phosphorylation of the T-bet DNA-Binding Domain Regulates CD4+ T-Cell Differentiation and Allergic Lung Inflammation. Mol Cell Biol 31(16):3445-56. [PubMed: 21690296]  [MGI Ref ID J:175086]

Chen Y; Langrish CL; McKenzie B; Joyce-Shaikh B; Stumhofer JS; McClanahan T; Blumenschein W; Churakovsa T; Low J; Presta L; Hunter CA; Kastelein RA; Cua DJ. 2006. Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis. J Clin Invest 116(5):1317-26. [PubMed: 16670771]  [MGI Ref ID J:108945]

Cobb D; Guo S; Lara AM; Manque P; Buck G; Smeltz RB. 2009. T-bet-dependent regulation of CD8+ T-cell expansion during experimental Trypanosoma cruzi infection. Immunology 128(4):589-99. [PubMed: 19824916]  [MGI Ref ID J:162286]

Cobb D; Hambright D; Smeltz RB. 2010. T-bet-independent effects of IL-12 family cytokines on regulation of Th17 responses to experimental T. cruzi infection. J Leukoc Biol 88(5):965-71. [PubMed: 20807701]  [MGI Ref ID J:166092]

Cobb D; Smeltz RB. 2012. Regulation of proinflammatory Th17 responses during Trypanosoma cruzi infection by IL-12 family cytokines. J Immunol 188(8):3766-73. [PubMed: 22412196]  [MGI Ref ID J:184072]

Collier SP; Collins PL; Williams CL; Boothby MR; Aune TM. 2012. Cutting edge: influence of Tmevpg1, a long intergenic noncoding RNA, on the expression of Ifng by Th1 cells. J Immunol 189(5):2084-8. [PubMed: 22851706]  [MGI Ref ID J:189858]

Collins PL; Chang S; Henderson M; Soutto M; Davis GM; McLoed AG; Townsend MJ; Glimcher LH; Mortlock DP; Aune TM. 2010. Distal regions of the human IFNG locus direct cell type-specific expression. J Immunol 185(3):1492-501. [PubMed: 20574006]  [MGI Ref ID J:162475]

Colpitts SL; Dalton NM; Scott P. 2009. IL-7 receptor expression provides the potential for long-term survival of both CD62L(high) central memory T cells and Th1 effector cells during Leishmania major infection. J Immunol 182(9):5702-11. [PubMed: 19380817]  [MGI Ref ID J:147945]

Cretney E; Xin A; Shi W; Minnich M; Masson F; Miasari M; Belz GT; Smyth GK; Busslinger M; Nutt SL; Kallies A. 2011. The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells. Nat Immunol 12(4):304-11. [PubMed: 21378976]  [MGI Ref ID J:170323]

Cruz-Guilloty F; Pipkin ME; Djuretic IM; Levanon D; Lotem J; Lichtenheld MG; Groner Y; Rao A. 2009. Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs. J Exp Med 206(1):51-9. [PubMed: 19139168]  [MGI Ref ID J:144022]

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Phoon RK; Kitching AR; Odobasic D; Jones LK; Semple TJ; Holdsworth SR. 2008. T-bet deficiency attenuates renal injury in experimental crescentic glomerulonephritis. J Am Soc Nephrol 19(3):477-85. [PubMed: 18235099]  [MGI Ref ID J:150169]

Pipkin ME; Sacks JA; Cruz-Guilloty F; Lichtenheld MG; Bevan MJ; Rao A. 2010. Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells. Immunity 32(1):79-90. [PubMed: 20096607]  [MGI Ref ID J:157692]

Powell N; Walker AW; Stolarczyk E; Canavan JB; Gokmen MR; Marks E; Jackson I; Hashim A; Curtis MA; Jenner RG; Howard JK; Parkhill J; Macdonald TT; Lord GM. 2012. The Transcription Factor T-bet Regulates Intestinal Inflammation Mediated by Interleukin-7 Receptor(+) Innate Lymphoid Cells. Immunity 37(4):674-84. [PubMed: 23063332]  [MGI Ref ID J:188554]

Qin H; Wang L; Feng T; Elson CO; Niyongere SA; Lee SJ; Reynolds SL; Weaver CT; Roarty K; Serra R; Benveniste EN; Cong Y. 2009. TGF-{beta} Promotes Th17 Cell Development through Inhibition of SOCS3. J Immunol 183(1):97-105. [PubMed: 19535626]  [MGI Ref ID J:150117]

Qui HZ; Hagymasi AT; Bandyopadhyay S; St Rose MC; Ramanarasimhaiah R; Menoret A; Mittler RS; Gordon SM; Reiner SL; Vella AT; Adler AJ. 2011. CD134 plus CD137 dual costimulation induces Eomesodermin in CD4 T cells to program cytotoxic Th1 differentiation. J Immunol 187(7):3555-64. [PubMed: 21880986]  [MGI Ref ID J:179327]

Rangachari M; Mauermann N; Marty RR; Dirnhofer S; Kurrer MO; Komnenovic V; Penninger JM; Eriksson U. 2006. T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17. J Exp Med 203(8):2009-19. [PubMed: 16880257]  [MGI Ref ID J:124393]

Rankin LC; Groom JR; Chopin M; Herold MJ; Walker JA; Mielke LA; McKenzie AN; Carotta S; Nutt SL; Belz GT. 2013. The transcription factor T-bet is essential for the development of NKp46(+) innate lymphocytes via the Notch pathway. Nat Immunol 14(4):389-95. [PubMed: 23455676]  [MGI Ref ID J:194819]

Rao RR; Li Q; Gubbels Bupp MR; Shrikant PA. 2012. Transcription factor Foxo1 represses T-bet-mediated effector functions and promotes memory CD8(+) T cell differentiation. Immunity 36(3):374-87. [PubMed: 22425248]  [MGI Ref ID J:187335]

Ravindran R; Foley J; Stoklasek T; Glimcher LH; McSorley SJ. 2005. Expression of T-bet by CD4 T cells is essential for resistance to Salmonella infection. J Immunol 175(7):4603-10. [PubMed: 16177105]  [MGI Ref ID J:118948]

Rivera A; Hohl TM; Collins N; Leiner I; Gallegos A; Saijo S; Coward JW; Iwakura Y; Pamer EG. 2011. Dectin-1 diversifies Aspergillus fumigatus-specific T cell responses by inhibiting T helper type 1 CD4 T cell differentiation. J Exp Med 208(2):369-81. [PubMed: 21242294]  [MGI Ref ID J:176853]

Robbins SH; Tessmer MS; Van Kaer L; Brossay L. 2005. Direct effects of T-bet and MHC class I expression, but not STAT1, on peripheral NK cell maturation. Eur J Immunol 35(3):757-65. [PubMed: 15719366]  [MGI Ref ID J:96620]

Rodriguez-Galan MC; Bream JH; Farr A; Young HA. 2005. Synergistic effect of IL-2, IL-12, and IL-18 on thymocyte apoptosis and Th1/Th2 cytokine expression. J Immunol 174(5):2796-804. [PubMed: 15728489]  [MGI Ref ID J:97710]

Rosas LE; Snider HM; Barbi J; Satoskar AA; Lugo-Villarino G; Keiser T; Papenfuss T; Durbin JE; Radzioch D; Glimcher LH; Satoskar AR. 2006. Cutting edge: STAT1 and T-bet play distinct roles in determining outcome of visceral leishmaniasis caused by Leishmania donovani. J Immunol 177(1):22-5. [PubMed: 16785492]  [MGI Ref ID J:134384]

Rose S; Guevara P; Farach S; Adkins B. 2006. The key regulators of adult T helper cell responses, STAT6 and T-bet, are established in early life in mice. Eur J Immunol 36(5):1241-53. [PubMed: 16568497]  [MGI Ref ID J:114781]

Rubtsova K; Rubtsov AV; van Dyk LF; Kappler JW; Marrack P. 2013. T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance. Proc Natl Acad Sci U S A 110(34):E3216-24. [PubMed: 23922396]  [MGI Ref ID J:200754]

Rutitzky LI; Smith PM; Stadecker MJ. 2009. T-bet protects against exacerbation of schistosome egg-induced immunopathology by regulating Th17-mediated inflammation. Eur J Immunol 39(9):2470-81. [PubMed: 19714576]  [MGI Ref ID J:152143]

Sabet-Baktach M; Eggenhofer E; Rovira J; Renner P; Lantow M; Farkas SA; Malaise M; Edtinger K; Shaotang Z; Koehl GE; Dahlke MH; Schlitt HJ; Geissler EK; Kroemer A. 2013. Double deficiency for RORgammat and T-bet drives Th2-mediated allograft rejection in mice. J Immunol 191(8):4440-6. [PubMed: 24058178]  [MGI Ref ID J:206252]

Sandy AR; Chung J; Toubai T; Shan GT; Tran IT; Friedman A; Blackwell TS; Reddy P; King PD; Maillard I. 2013. T cell-specific notch inhibition blocks graft-versus-host disease by inducing a hyporesponsive program in alloreactive CD4+ and CD8+ T cells. J Immunol 190(11):5818-28. [PubMed: 23636056]  [MGI Ref ID J:204766]

Sauer KA; Maxeiner JH; Karwot R; Scholtes P; Lehr HA; Birkenbach M; Blumberg RS; Finotto S. 2008. Immunosurveillance of lung melanoma metastasis in EBI-3-deficient mice mediated by CD8+ T cells. J Immunol 181(9):6148-57. [PubMed: 18941205]  [MGI Ref ID J:140735]

Schmolka N; Serre K; Grosso AR; Rei M; Pennington DJ; Gomes AQ; Silva-Santos B. 2013. Epigenetic and transcriptional signatures of stable versus plastic differentiation of proinflammatory gammadelta T cell subsets. Nat Immunol 14(10):1093-100. [PubMed: 23995235]  [MGI Ref ID J:208217]

Sciume G; Hirahara K; Takahashi H; Laurence A; Villarino AV; Singleton KL; Spencer SP; Wilhelm C; Poholek AC; Vahedi G; Kanno Y; Belkaid Y; O'Shea JJ. 2012. Distinct requirements for T-bet in gut innate lymphoid cells. J Exp Med 209(13):2331-8. [PubMed: 23209316]  [MGI Ref ID J:194630]

Serre K; Cunningham AF; Coughlan RE; Lino AC; Rot A; Hub E; Moser K; Manz R; Ferraro A; Bird R; Toellner KM; Demengeot J; MacLennan IC; Mohr E. 2012. CD8 T cells induce T-bet-dependent migration toward CXCR3 ligands by differentiated B cells produced during responses to alum-protein vaccines. Blood 120(23):4552-9. [PubMed: 23065152]  [MGI Ref ID J:190901]

Shanmugam NK; Ellenbogen S; Trebicka E; Wang L; Mukhopadhyay S; Lacy-Hulbert A; Gallini CA; Garrett WS; Cherayil BJ. 2012. Tumor necrosis factor alpha inhibits expression of the iron regulating hormone hepcidin in murine models of innate colitis. PLoS One 7(5):e38136. [PubMed: 22675442]  [MGI Ref ID J:187286]

Shinohara ML; Jansson M; Hwang ES; Werneck MB; Glimcher LH; Cantor H. 2005. T-bet-dependent expression of osteopontin contributes to T cell polarization. Proc Natl Acad Sci U S A 102(47):17101-6. [PubMed: 16286640]  [MGI Ref ID J:103835]

Siebler J; Wirtz S; Weigmann B; Atreya I; Schmitt E; Kreft A; Galle PR; Neurath MF. 2007. IL-28A is a key regulator of T-cell-mediated liver injury via the T-box transcription factor T-bet. Gastroenterology 132(1):358-71. [PubMed: 17241885]  [MGI Ref ID J:127278]

Stoicov C; Fan X; Liu JH; Bowen G; Whary M; Kurt-Jones E; Houghton J. 2009. T-bet knockout prevents Helicobacter felis-induced gastric cancer. J Immunol 183(1):642-9. [PubMed: 19535625]  [MGI Ref ID J:150118]

Stumhofer JS; Laurence A; Wilson EH; Huang E; Tato CM; Johnson LM; Villarino AV; Huang Q; Yoshimura A; Sehy D; Saris CJ; O'Shea JJ; Hennighausen L; Ernst M; Hunter CA. 2006. Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat Immunol 7(9):937-45. [PubMed: 16906166]  [MGI Ref ID J:112649]

Sullivan BM; Jobe O; Lazarevic V; Vasquez K; Bronson R; Glimcher LH; Kramnik I. 2005. Increased susceptibility of mice lacking T-bet to infection with Mycobacterium tuberculosis correlates with increased IL-10 and decreased IFN-gamma production. J Immunol 175(7):4593-602. [PubMed: 16177104]  [MGI Ref ID J:118949]

Sullivan BM; Juedes A; Szabo SJ; von Herrath M; Glimcher LH. 2003. Antigen-driven effector CD8 T cell function regulated by T-bet. Proc Natl Acad Sci U S A 100(26):15818-23. [PubMed: 14673093]  [MGI Ref ID J:88140]

Sutherland AP; Joller N; Michaud M; Liu SM; Kuchroo VK; Grusby MJ. 2013. IL-21 Promotes CD8+ CTL Activity via the Transcription Factor T-bet. J Immunol 190(8):3977-84. [PubMed: 23479229]  [MGI Ref ID J:194899]

Svensson A; Nordstrom I; Sun JB; Eriksson K. 2005. Protective immunity to genital herpes simplex [correction of simpex] virus type 2 infection is mediated by T-bet. J Immunol 174(10):6266-73. [PubMed: 15879125]  [MGI Ref ID J:99048]

Szabo SJ; Sullivan BM; Stemmann C; Satoskar AR; Sleckman BP; Glimcher LH. 2002. Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science 295(5553):338-42. [PubMed: 11786644]  [MGI Ref ID J:73833]

Takahashi H; Kanno T; Nakayamada S; Hirahara K; Sciume G; Muljo SA; Kuchen S; Casellas R; Wei L; Kanno Y; O'Shea JJ. 2012. TGF-beta and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells. Nat Immunol 13(6):587-95. [PubMed: 22544395]  [MGI Ref ID J:186450]

Tamachi T; Takatori H; Fujiwara M; Hirose K; Maezawa Y; Kagami S; Suto A; Watanabe N; Iwamoto I; Nakajima H. 2009. STAT6 inhibits T-bet-independent Th1 cell differentiation. Biochem Biophys Res Commun 382(4):751-5. [PubMed: 19324016]  [MGI Ref ID J:148350]

Taqueti VR; Grabie N; Colvin R; Pang H; Jarolim P; Luster AD; Glimcher LH; Lichtman AH. 2006. T-bet controls pathogenicity of CTLs in the heart by separable effects on migration and effector activity. J Immunol 177(9):5890-901. [PubMed: 17056513]  [MGI Ref ID J:140534]

Thieu VT; Yu Q; Chang HC; Yeh N; Nguyen ET; Sehra S; Kaplan MH. 2008. Signal transducer and activator of transcription 4 is required for the transcription factor T-bet to promote T helper 1 cell-fate determination. Immunity 29(5):679-90. [PubMed: 18993086]  [MGI Ref ID J:143179]

Tofukuji S; Kuwahara M; Suzuki J; Ohara O; Nakayama T; Yamashita M. 2012. Identification of a new pathway for Th1 cell development induced by cooperative stimulation with IL-4 and TGF-beta. J Immunol 188(10):4846-57. [PubMed: 22504655]  [MGI Ref ID J:188669]

Townsend MJ; Weinmann AS; Matsuda JL; Salomon R; Farnham PJ; Biron CA; Gapin L; Glimcher LH. 2004. T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells. Immunity 20(4):477-94. [PubMed: 15084276]  [MGI Ref ID J:89776]

Trotta R; Col JD; Yu J; Ciarlariello D; Thomas B; Zhang X; Allard J nd; Wei M; Mao H; Byrd JC; Perrotti D; Caligiuri MA. 2008. TGF-beta utilizes SMAD3 to inhibit CD16-mediated IFN-gamma production and antibody-dependent cellular cytotoxicity in human NK cells. J Immunol 181(6):3784-92. [PubMed: 18768831]  [MGI Ref ID J:139114]

Tumes DJ; Onodera A; Suzuki A; Shinoda K; Endo Y; Iwamura C; Hosokawa H; Koseki H; Tokoyoda K; Suzuki Y; Motohashi S; Nakayama T. 2013. The polycomb protein Ezh2 regulates differentiation and plasticity of CD4(+) T helper type 1 and type 2 cells. Immunity 39(5):819-32. [PubMed: 24238339]  [MGI Ref ID J:208988]

Tzianabos AO; Holsti MA; Zheng XX; Stucchi AF; Kuchroo VK; Strom TB; Glimcher LH; Cruikshank WW. 2008. Functional Th1 cells are required for surgical adhesion formation in a murine model. J Immunol 180(10):6970-6. [PubMed: 18453619]  [MGI Ref ID J:134863]

Underhill GH; Zisoulis DG; Kolli KP; Ellies LG; Marth JD; Kansas GS. 2005. A crucial role for T-bet in selectin ligand expression in T helper 1 (Th1) cells. Blood 106(12):3867-73. [PubMed: 16099875]  [MGI Ref ID J:124068]

Veiga P; Gallini CA; Beal C; Michaud M; Delaney ML; DuBois A; Khlebnikov A; van Hylckama Vlieg JE; Punit S; Glickman JN; Onderdonk A; Glimcher LH; Garrett WS. 2010. Bifidobacterium animalis subsp. lactis fermented milk product reduces inflammation by altering a niche for colitogenic microbes. Proc Natl Acad Sci U S A 107(42):18132-7. [PubMed: 20921388]  [MGI Ref ID J:165540]

Verykokakis M; Krishnamoorthy V; Iavarone A; Lasorella A; Sigvardsson M; Kee BL. 2013. Essential functions for ID proteins at multiple checkpoints in invariant NKT cell development. J Immunol 191(12):5973-83. [PubMed: 24244015]  [MGI Ref ID J:207115]

Villarino AV; Artis D; Bezbradica JS; Miller O; Saris CJ; Joyce S; Hunter CA. 2008. IL-27R deficiency delays the onset of colitis and protects from helminth-induced pathology in a model of chronic IBD. Int Immunol 20(6):739-52. [PubMed: 18375937]  [MGI Ref ID J:136179]

Villarino AV; Gallo E; Abbas AK. 2010. STAT1-activating cytokines limit Th17 responses through both T-bet-dependent and -independent mechanisms. J Immunol 185(11):6461-71. [PubMed: 20974984]  [MGI Ref ID J:167369]

Villarino AV; Stumhofer JS; Saris CJ; Kastelein RA; de Sauvage FJ; Hunter CA. 2006. IL-27 limits IL-2 production during Th1 differentiation. J Immunol 176(1):237-47. [PubMed: 16365415]  [MGI Ref ID J:126267]

Wang J; Fathman JW; Lugo-Villarino G; Scimone L; von Andrian U; Dorfman DM; Glimcher LH. 2006. Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cells. J Clin Invest 116(2):414-21. [PubMed: 16410834]  [MGI Ref ID J:105447]

Wang NS; McHeyzer-Williams LJ; Okitsu SL; Burris TP; Reiner SL; McHeyzer-Williams MG. 2012. Divergent transcriptional programming of class-specific B cell memory by T-bet and RORalpha. Nat Immunol 13(6):604-11. [PubMed: 22561605]  [MGI Ref ID J:186447]

Way SS; Wilson CB. 2004. Cutting edge: immunity and IFN-gamma production during Listeria monocytogenes infection in the absence of T-bet. J Immunol 173(10):5918-22. [PubMed: 15528324]  [MGI Ref ID J:94293]

Werneck MB; Lugo-Villarino G; Hwang ES; Cantor H; Glimcher LH. 2008. T-bet plays a key role in NK-mediated control of melanoma metastatic disease. J Immunol 180(12):8004-10. [PubMed: 18523263]  [MGI Ref ID J:137244]

Williams CA; Murray SE; Weinberg AD; Parker DC. 2007. OX40-mediated differentiation to effector function requires IL-2 receptor signaling but not CD28, CD40, IL-12Rbeta2, or T-bet. J Immunol 178(12):7694-702. [PubMed: 17548606]  [MGI Ref ID J:148588]

Williams CL; Schilling MM; Cho SH; Lee K; Wei M; Aditi; Boothby M. 2013. STAT4 and T-bet are required for the plasticity of IFN-gamma expression across Th2 ontogeny and influence changes in Ifng promoter DNA methylation. J Immunol 191(2):678-87. [PubMed: 23761633]  [MGI Ref ID J:204820]

Withers DR; Jaensson E; Gaspal F; McConnell FM; Eksteen B; Anderson G; Agace WW; Lane PJ. 2009. The survival of memory CD4+ T cells within the gut lamina propria requires OX40 and CD30 signals. J Immunol 183(8):5079-84. [PubMed: 19786532]  [MGI Ref ID J:153824]

Wu J; Yang J; Yang K; Wang H; Gorentla B; Shin J; Qiu Y; Que LG; Foster WM; Xia Z; Chi H; Zhong XP. 2014. iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions. J Clin Invest 124(4):1685-98. [PubMed: 24614103]  [MGI Ref ID J:209612]

Wuthrich M; Gern B; Hung CY; Ersland K; Rocco N; Pick-Jacobs J; Galles K; Filutowicz H; Warner T; Evans M; Cole G; Klein B. 2011. Vaccine-induced protection against 3 systemic mycoses endemic to North America requires Th17 cells in mice. J Clin Invest 121(2):554-68. [PubMed: 21206087]  [MGI Ref ID J:171835]

Xu J; Mora AL; LaVoy J; Brigham KL; Rojas M. 2006. Increased bleomycin-induced lung injury in mice deficient in the transcription factor T-bet. Am J Physiol Lung Cell Mol Physiol 291(4):L658-67. [PubMed: 16648243]  [MGI Ref ID J:144409]

Xu J; Yang Y; Qiu G; Lal G; Yin N; Wu Z; Bromberg JS; Ding Y. 2011. Stat4 Is Critical for the Balance between Th17 Cells and Regulatory T Cells in Colitis. J Immunol 186(11):6597-606. [PubMed: 21525389]  [MGI Ref ID J:173182]

Yagi R; Junttila IS; Wei G; Urban JF Jr; Zhao K; Paul WE; Zhu J. 2010. The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma. Immunity 32(4):507-17. [PubMed: 20399120]  [MGI Ref ID J:160369]

Yang Q; Li G; Zhu Y; Liu L; Chen E; Turnquist H; Zhang X; Finn OJ; Chen X; Lu B. 2011. IL-33 synergizes with TCR and IL-12 signaling to promote the effector function of CD8+ T cells. Eur J Immunol 41(11):3351-60. [PubMed: 21887788]  [MGI Ref ID J:179516]

Yang Y; Ochando JC; Bromberg JS; Ding Y. 2007. Identification of a distant T-bet enhancer responsive to IL-12/Stat4 and IFNgamma/Stat1 signals. Blood 110(7):2494-500. [PubMed: 17575072]  [MGI Ref ID J:147019]

Yang Y; Weiner J; Liu Y; Smith AJ; Huss DJ; Winger R; Peng H; Cravens PD; Racke MK; Lovett-Racke AE. 2009. T-bet is essential for encephalitogenicity of both Th1 and Th17 cells. J Exp Med 206(7):1549-64. [PubMed: 19546248]  [MGI Ref ID J:150271]

Yang Y; Xu J; Niu Y; Bromberg JS; Ding Y. 2008. T-bet and Eomesodermin play critical roles in directing T cell differentiation to Th1 versus Th17. J Immunol 181(12):8700-10. [PubMed: 19050290]  [MGI Ref ID J:142051]

Yeh N; Glosson NL; Wang N; Guindon L; McKinley C; Hamada H; Li Q; Dutton RW; Shrikant P; Zhou B; Brutkiewicz RR; Blum JS; Kaplan MH. 2010. Tc17 cells are capable of mediating immunity to vaccinia virus by acquisition of a cytotoxic phenotype. J Immunol 185(4):2089-98. [PubMed: 20624947]  [MGI Ref ID J:162382]

Yu Y; Wang D; Liu C; Kaosaard K; Semple K; Anasetti C; Yu XZ. 2011. Prevention of GVHD while sparing GVL effect by targeting Th1 and Th17 transcription factor T-bet and RORgammat in mice. Blood 118(18):5011-20. [PubMed: 21856864]  [MGI Ref ID J:178805]

Yuan X; Ansari MJ; D'Addio F; Paez-Cortez J; Schmitt I; Donnarumma M; Boenisch O; Zhao X; Popoola J; Clarkson MR; Yagita H; Akiba H; Freeman GJ; Iacomini J; Turka LA; Glimcher LH; Sayegh MH. 2009. Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells. Proc Natl Acad Sci U S A 106(26):10734-9. [PubMed: 19528638]  [MGI Ref ID J:150842]

Zhang F; Boothby M. 2006. T helper type 1-specific Brg1 recruitment and remodeling of nucleosomes positioned at the IFN-gamma promoter are Stat4 dependent. J Exp Med 203(6):1493-505. [PubMed: 16717115]  [MGI Ref ID J:124379]

Zhu J; Jankovic D; Oler AJ; Wei G; Sharma S; Hu G; Guo L; Yagi R; Yamane H; Punkosdy G; Feigenbaum L; Zhao K; Paul WE. 2012. The Transcription Factor T-bet Is Induced by Multiple Pathways and Prevents an Endogenous Th2 Cell Program during Th1 Cell Responses. Immunity 37(4):660-73. [PubMed: 23041064]  [MGI Ref ID J:188559]

Zhu Y; Ju S; Chen E; Dai S; Li C; Morel P; Liu L; Zhang X; Lu B. 2010. T-bet and Eomesodermin are required for T cell-mediated antitumor immune responses. J Immunol 185(6):3174-83. [PubMed: 20713880]  [MGI Ref ID J:163822]

Zhuang Y; Huang Z; Nishida J; Brown M; Zhang L; Huang H. 2009. A continuous T-bet expression is required to silence the interleukin-4-producing potential in T helper type 1 cells. Immunology 128(1):34-42. [PubMed: 19689734]  [MGI Ref ID J:162295]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX18

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, these mice are bred as homozygotes. Coat color expected from breeding is Albino.
Mating SystemHomozygote x Homozygote         (Female x Male)   05-APR-13
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $199.90Female or MaleHomozygous for Tbx21tm1Glm  
Price per Pair (US dollars $)Pair Genotype
$399.80Homozygous for Tbx21tm1Glm x Homozygous for Tbx21tm1Glm  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $259.90Female or MaleHomozygous for Tbx21tm1Glm  
Price per Pair (US dollars $)Pair Genotype
$519.80Homozygous for Tbx21tm1Glm x Homozygous for Tbx21tm1Glm  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

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   000651 BALB/cJ
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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