| |||||||
- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Type Congenic; Mutant Strain; Targeted Mutation; Additional information on Genetically Engineered Mutant Mice. Species laboratory mouse Background Strain NOD Donor Strain 129P2 H2 Haplotype g7 Generation N12F?+2p Donating Investigator Christophe Benoist, Joslin Diabetes Center Appearance
albino, pink eyed
Related Genotype: A/A Tyrc/TyrcDescription
NOD mice homozygous for the Tcratm1Mjo targeted mutation lack alpha beta T cells, and therefore, are completely protected from diabetes development. Because of the complete elimination of alpha beta T cells, these mice are useful in adoptive transfer experiments (as in Hoglund et al. 1999).Development
The Tcratm1Mjo targeted mutation was generated in GK129 ES cells (derived from substrain129P2/OlaHsd) via homologous recombination which inserted the neomycin resistance gene under the control of a eukaryotic promoter into the first constant region of the Tcra gene. ES cells carrying the disrupted gene were injected into BALB/c blastocysts, chimeric founders were bred with BALB/c females, and their heterozygous offspring were sibling mated to homozygosity. The Tcratm1Mjo allele on the C;129 mixed background was then transfered to the NOD background and in July 2002 the generation of this strain was N12. (Philpott et al. 1992.)
Control Information
| Control | ||
|---|---|---|
| 001976 NOD/ShiLtJ | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of Tcra
View Strains carrying other alleles of Tcra (35 strains)
Additional Web Information
Congenic Nomenclature
Phenotype
Phenotype Information
assigned by genotype
Tcratm1Mjo/Tcratm1Mjo
NOD.129P2-Tcratm1Mjo
- immune system phenotype
- increased activated T cell number (MGI Ref ID J:52940)
- when splenic T cells from BDC2.5 transgenic mice are transferred to Tcra deficient mice, significant proliferation of transferred splenocytes is detected in the pancreatic lymph nodes but not in the spleen or other lymph nodes 3 days after transfer
- when T cells from adult BDC2.5 transgenics are transferred to 10 day old or adult Tcra-deficient NOD mice, proliferation of T cells is detected after 3 days only in adult hosts in pancreatic lymph nodes
- hematopoietic system phenotype
- increased activated T cell number (MGI Ref ID J:52940)
- when splenic T cells from BDC2.5 transgenic mice are transferred to Tcra deficient mice, significant proliferation of transferred splenocytes is detected in the pancreatic lymph nodes but not in the spleen or other lymph nodes 3 days after transfer
- when T cells from adult BDC2.5 transgenics are transferred to 10 day old or adult Tcra-deficient NOD mice, proliferation of T cells is detected after 3 days only in adult hosts in pancreatic lymph nodes
This mouse can be used to support research in many areas including:
Tcratm1Mjo relatedDiabetes and Obesity Research
Type 1 Diabetes (IDDM) Analysis Strains (NOD Congenics with Mutations Affecting Immunocompetence)
Hematological Research
Immunological Defects
Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunodeficiency
Inflammation
T Cell Receptor Signaling Defects
Research Tools
Cancer Research (specific T cell deficiency)
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Tcratm1Mjo | ||
|---|---|---|---|
| Allele Name | targeted mutation 1, Michael J Owen | ||
| Allele Type | Targeted (knock-out) | ||
| Common Name(s) | Calpha-; TCRalpha; TCRalpha KO; TCRalphae-; Tcralpha-; | ||
| Strain of Origin | 129P2/OlaHsd | ||
| ES Cell Line Name | GK129 | ||
| ES Cell Line Strain | 129P2/OlaHsd | ||
| Gene Symbol and Name | Tcra, T-cell receptor alpha chain | ||
| Chromosome | 14 | ||
| Gene Common Name(s) | OTTMUSG00000015028; Tcr alpha; Tcralpha; predicted gene, OTTMUSG00000015028; | ||
| Molecular Note | The Tcra-C element C1 was disrupted by the insertion of a neomycin selection cassette. [MGI Ref ID J:1292] | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Optimizing PCR Protocols
References
References
Selected Reference(s)
Philpott KL; Viney JL; Kay G; Rastan S; Gardiner EM; Chae S; Hayday AC; Owen MJ. 1992. Lymphoid development in mice congenitally lacking T cell receptor alpha beta-expressing cells. Science 256(5062):1448-52. [PubMed: 1604321] [MGI Ref ID J:1292]
Additional References
Tcratm1Mjo relatedAu-Yeung BB; Katzman SD; Fowell DJ. 2006. Cutting edge: Itk-dependent signals required for CD4+ T cells to exert, but not gain, Th2 effector function. J Immunol 176(7):3895-9. [PubMed: 16547221] [MGI Ref ID J:129883]
Blyth K; Vaillant F; Hanlon L; Mackay N; Bell M; Jenkins A; Neil JC; Cameron ER. 2006. Runx2 and MYC collaborate in lymphoma development by suppressing apoptotic and growth arrest pathways in vivo. Cancer Res 66(4):2195-201. [PubMed: 16489021] [MGI Ref ID J:106649]
Bosco N; Hung HC; Pasqual N; Jouvin-Marche E; Marche PN; Gascoigne NR; Ceredig R. 2006. Role of the T cell receptor alpha chain in the development and phenotype of naturally arising CD4+CD25+ T cells. Mol Immunol 43(3):246-54. [PubMed: 16199261] [MGI Ref ID J:104864]
Bour-Jordan H; Salomon BL; Thompson HL; Santos R; Abbas AK; Bluestone JA. 2007. Constitutive expression of B7-1 on B cells uncovers autoimmunity toward the B cell compartment in the nonobese diabetic mouse. J Immunol 179(2):1004-12. [PubMed: 17617592] [MGI Ref ID J:131077]
Capone M; Cantarella D; Schumann J; Naidenko OV; Garavaglia C; Beermann F; Kronenberg M; Dellabona P; MacDonald HR; Casorati G. 2003. Human invariant V alpha 24-J alpha Q TCR supports the development of CD1d-dependent NK1.1+ and NK1.1- T cells in transgenic mice. J Immunol 170(5):2390-8. [PubMed: 12594262] [MGI Ref ID J:82014]
Cobaleda C; Jochum W; Busslinger M. 2007. Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors. Nature 449(7161):473-7. [PubMed: 17851532] [MGI Ref ID J:126362]
Coles MC; Veiga-Fernandes H; Foster KE; Norton T; Pagakis SN; Seddon B; Kioussis D. 2006. Role of T and NK cells and IL7/IL7r interactions during neonatal maturation of lymph nodes. Proc Natl Acad Sci U S A 103(36):13457-62. [PubMed: 16938836] [MGI Ref ID J:112903]
Correia-Neves M; Mathis D; Benoist C. 2001. A molecular chart of thymocyte positive selection. Eur J Immunol 31(9):2583-92. [PubMed: 11536156] [MGI Ref ID J:115618]
Correia-Neves M; Waltzinger C; Mathis D; Benoist C. 2001. The shaping of the T cell repertoire. Immunity 14(1):21-32. [PubMed: 11163227] [MGI Ref ID J:132246]
Corthay A; Nandakumar KS; Holmdahl R. 2001. Evaluation of the Percentage of Peripheral T Cells with Two Different T Cell Receptor alpha-Chains and of their Potential Role in Autoimmunity. J Autoimmun 16(4):423-9. [PubMed: 11437490] [MGI Ref ID J:70152]
Crompton T; Gilmour KC; Owen MJ. 1996. The MAP kinase pathway controls differentiation from double-negative to double-positive thymocyte. Cell 86(2):243-51. [PubMed: 8706129] [MGI Ref ID J:34462]
Di Santo JP; Aifantis I; Rosmaraki E; Garcia C; Feinberg J; Fehling HJ; Fischer A; von Boehmer H; Rocha B. 1999. The common cytokine receptor gamma chain and the pre-T cell receptor provide independent but critically overlapping signals in early alpha/beta T cell development. J Exp Med 189(3):563-74. [PubMed: 9927518] [MGI Ref ID J:52569]
Dianda L; Hanby AM; Wright NA; Sebesteny A; Hayday AC; Owen MJ. 1997. T cell receptor-alpha beta-deficient mice fail to develop colitis in the absence of a microbial environment. Am J Pathol 150(1):91-7. [PubMed: 9006326] [MGI Ref ID J:37699]
Elliott JI. 1998. Selection of dual Valpha T cells. Eur J Immunol 28(7):2115-23. [PubMed: 9692880] [MGI Ref ID J:49315]
Elliott JI; Altmann DM. 1995. Dual T cell receptor alpha chain T cells in autoimmunity. J Exp Med 182(4):953-9. [PubMed: 7561698] [MGI Ref ID J:108590]
Elliott JI; Altmann DM. 1996. Non-obese diabetic mice hemizygous at the T cell receptor alpha locus are susceptible to diabetes and sialitis. Eur J Immunol 26(4):953-956. [PubMed: 8625995] [MGI Ref ID J:32586]
Faulkner L; Cooper A; Fantino C; Altmann DM; Sriskandan S. 2005. The mechanism of superantigen-mediated toxic shock: not a simple Th1 cytokine storm. J Immunol 175(10):6870-7. [PubMed: 16272345] [MGI Ref ID J:119695]
Fowell DJ; Shinkai K; Liao XC; Beebe AM; Coffman RL; Littman DR; Locksley RM. 1999. Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells. Immunity 11(4):399-409. [PubMed: 10549622] [MGI Ref ID J:109489]
Granucci F; Di Tota FP; Raimondi G; Citterio S; Rescigno M; Ricciardi-Castagnoli P. 2001. Autoreactive isotype-specific T cells determine B cell frequency. Eur J Immunol 31(1):215-24. [PubMed: 11265637] [MGI Ref ID J:118406]
Hadeiba H; Locksley RM. 2003. Lung CD25 CD4 regulatory T cells suppress type 2 immune responses but not bronchial hyperreactivity. J Immunol 170(11):5502-10. [PubMed: 12759427] [MGI Ref ID J:109990]
Herlands RA; Christensen SR; Sweet RA; Hershberg U; Shlomchik MJ. 2008. T Cell-Independent and Toll-like Receptor-Dependent Antigen-Driven Activation of Autoreactive B Cells. Immunity 29(2):249-60. [PubMed: 18691914] [MGI Ref ID J:139567]
Hoglund P; Mintern J; Waltzinger C; Heath W; Benoist C; Mathis D. 1999. Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes. J Exp Med 189(2):331-9. [PubMed: 9892615] [MGI Ref ID J:52940]
Hughes DP; Hayday A; Craft JE; Owen MJ; Crispe IN. 1995. T cells with gamma/delta T cell receptors (TCR) of intestinal type are preferentially expanded in TCR-alpha-deficient lpr mice. J Exp Med 182(1):233-41. [PubMed: 7540652] [MGI Ref ID J:26250]
Irla M; Hugues S; Gill J; Nitta T; Hikosaka Y; Williams IR; Hubert FX; Scott HS; Takahama Y; Hollander GA; Reith W. 2008. Autoantigen-specific interactions with CD4+ thymocytes control mature medullary thymic epithelial cell cellularity. Immunity 29(3):451-63. [PubMed: 18799151] [MGI Ref ID J:139647]
Kirberg J; Baron A; Jakob S; Rolink A; Karjalainen K; von Boehmer H. 1994. Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor. J Exp Med 180(1):25-34. [PubMed: 8006585] [MGI Ref ID J:86429]
Kouskoff V; Korganow AS; Duchatelle V; Degott C; Benoist C; Mathis D. 1996. Organ-specific disease provoked by systemic autoimmunity. Cell 87(5):811-22. [PubMed: 8945509] [MGI Ref ID J:36815]
Lawson BR; Koundouris SI; Barnhouse M; Dummer W; Baccala R; Kono DH; Theofilopoulos AN. 2001. The role of alpha beta+ T cells and homeostatic T cell proliferation in Y-chromosome-associated murine lupus. J Immunol 167(4):2354-60. [PubMed: 11490025] [MGI Ref ID J:120153]
Luhder F; Chambers C; Allison JP; Benoist C; Mathis D. 2000. Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells. Proc Natl Acad Sci U S A 97(22):12204-9. [PubMed: 11035773] [MGI Ref ID J:109887]
Luhder F; Katz J; Benoist C; Mathis D. 1998. Major histocompatibility complex class II molecules can protect from diabetes by positively selecting T cells with additional specificities. J Exp Med 187(3):379-87. [PubMed: 9449718] [MGI Ref ID J:108722]
Maloy KJ; Burkhart C; Freer G; Rulicke T; Pircher H; Kono DH; Theofilopoulos AN; Ludewig B; Hoffmann-Rohrer U; Zinkernagel RM; Hengartner H. 1999. Qualitative and quantitative requirements for CD4+ T cell-mediated antiviral protection. J Immunol 162(5):2867-74. [PubMed: 10072535] [MGI Ref ID J:114743]
Peng SL; Cappadona J; McNiff JM; Madaio MP; Owen MJ; Hayday AC; Craft J. 1998. Pathogenesis of autoimmunity in alphabeta T cell-deficient lupus-prone mice. Clin Exp Immunol 111(1):107-16. [PubMed: 9472669] [MGI Ref ID J:45448]
Peng SL; Madaio MP; Hughes DP; Crispe IN; Owen MJ; Wen L; Hayday AC; Craft J. 1996. Murine lupus in the absence of alpha beta T cells. J Immunol 156(10):4041-9. [PubMed: 8621947] [MGI Ref ID J:32944]
Peng SL; McNiff JM; Madaio MP; Ma J; Owen MJ; Flavell RA; Hayday AC ; Craft J. 1997. alpha beta T cell regulation and CD40 ligand dependence in murine systemic autoimmunity. J Immunol 158(5):2464-70. [PubMed: 9036998] [MGI Ref ID J:38492]
Pennington DJ; Silva-Santos B; Shires J; Theodoridis E; Pollitt C; Wise EL; Tigelaar RE; Owen MJ; Hayday AC. 2003. The inter-relatedness and interdependence of mouse T cell receptor gammadelta+ and alphabeta+ cells. Nat Immunol 4(10):991-8. [PubMed: 14502287] [MGI Ref ID J:125582]
Pennington DJ; Silva-Santos B; Silberzahn T; Escorcio-Correia M; Woodward MJ; Roberts SJ; Smith AL; Dyson PJ; Hayday AC. 2006. Early events in the thymus affect the balance of effector and regulatory T cells. Nature 444(7122):1073-7. [PubMed: 17190001] [MGI Ref ID J:117487]
Raimondi G; Zanoni I; Citterio S; Ricciardi-Castagnoli P; Granucci F. 2006. Induction of peripheral T cell tolerance by antigen-presenting B cells. I. Relevance of antigen presentation persistence. J Immunol 176(7):4012-20. [PubMed: 16547236] [MGI Ref ID J:129897]
Raimondi G; Zanoni I; Citterio S; Ricciardi-Castagnoli P; Granucci F. 2006. Induction of peripheral T cell tolerance by antigen-presenting B cells. II. Chronic antigen presentation overrules antigen-presenting B cell activation. J Immunol 176(7):4021-8. [PubMed: 16547237] [MGI Ref ID J:129896]
Sant'Angelo DB; Janeway CA Jr. 2002. Negative selection of thymocytes expressing the D10 TCR. Proc Natl Acad Sci U S A 99(10):6931-6. [PubMed: 12011450] [MGI Ref ID J:76534]
Scheu S; Stetson DB; Reinhardt RL; Leber JH; Mohrs M; Locksley RM. 2006. Activation of the integrated stress response during T helper cell differentiation. Nat Immunol 7(6):644-51. [PubMed: 16680145] [MGI Ref ID J:112676]
Schmid CD; Stienekemeier M; Oehen S; Bootz F; Zielasek J; Gold R; Toyka KV; Schachner M; Martini R. 2000. Immune deficiency in mouse models for inherited peripheral neuropathies leads to improved myelin maintenance. J Neurosci 20(2):729-35. [PubMed: 10632602] [MGI Ref ID J:59319]
Schumann J; Mycko MP; Dellabona P; Casorati G; MacDonald HR. 2006. Cutting edge: influence of the TCR Vbeta domain on the selection of semi-invariant NKT cells by endogenous ligands. J Immunol 176(4):2064-8. [PubMed: 16455960] [MGI Ref ID J:129129]
Solomon S; Kolb C; Mohanty S; Jeisy-Walder E; Preyer R; Schollhorn V; Illges H. 2002. Transmission of antibody-induced arthritis is independent of complement component 4 (C4) and the complement receptors 1 and 2 (CD21/35). Eur J Immunol 32(3):644-51. [PubMed: 11857338] [MGI Ref ID J:115361]
Tritt M; Sgouroudis E; d'Hennezel E; Albanese A; Piccirillo CA. 2008. Functional waning of naturally occurring CD4+ regulatory T-cells contributes to the onset of autoimmune diabetes. Diabetes 57(1):113-23. [PubMed: 17928397] [MGI Ref ID J:132415]
Ueno A; Cho S; Cheng L; Wang J; Hou S; Nakano H; Santamaria P; Yang Y. 2007. Transient upregulation of indoleamine 2,3-dioxygenase in dendritic cells by human chorionic gonadotropin downregulates autoimmune diabetes. Diabetes 56(6):1686-93. [PubMed: 17360980] [MGI Ref ID J:126514]
Viney JL; Dianda L; Roberts SJ; Wen L; Mallick CA; Hayday AC; Owen MJ. 1994. Lymphocyte proliferation in mice congenitally deficient in T-cell receptor alpha beta + cells. Proc Natl Acad Sci U S A 91(25):11948-52. [PubMed: 7991563] [MGI Ref ID J:110898]
Wei DG; Lee H; Park SH; Beaudoin L; Teyton L; Lehuen A; Bendelac A. 2005. Expansion and long-range differentiation of the NKT cell lineage in mice expressing CD1d exclusively on cortical thymocytes. J Exp Med 202(2):239-48. [PubMed: 16027237] [MGI Ref ID J:100545]
Wen L; Roberts SJ; Viney JL; Wong FS; Mallick C; Findly RC; Peng Q; Craft JE; Owen MJ; Hayday AC. 1994. Immunoglobulin synthesis and generalized autoimmunity in mice congenitally deficient in alpha beta(+) T cells. Nature 369(6482):654-8. [PubMed: 8208291] [MGI Ref ID J:111129]
Wu HJ; Sawaya H; Binstadt B; Brickelmaier M; Blasius A; Gorelik L; Mahmood U; Weissleder R; Carulli J; Benoist C; Mathis D. 2007. Inflammatory arthritis can be reined in by CpG-induced DC-NK cell cross talk. J Exp Med 204(8):1911-22. [PubMed: 17646407] [MGI Ref ID J:125952]
dos Santos NR; Rickman DS; de Reynies A; Cormier F; Williame M; Blanchard C; Stern MH; Ghysdael J. 2007. Pre-TCR expression cooperates with TEL-JAK2 to transform immature thymocytes and induce T-cell leukemia. Blood 109(9):3972-81. [PubMed: 17192390] [MGI Ref ID J:121496]
dos Santos NR; Williame M; Gachet S; Cormier F; Janin A; Weih D; Weih F; Ghysdael J. 2008. RelB-dependent stromal cells promote T-cell leukemogenesis. PLoS ONE 3(7):e2555. [PubMed: 18596915] [MGI Ref ID J:137965]
van Schaik SM; Abbas AK. 2007. Role of T cells in a murine model of Escherichia coli sepsis. Eur J Immunol 37(11):3101-10. [PubMed: 17948264] [MGI Ref ID J:126313]
Health & husbandry
Health & Colony Maintenance Information
Currently there no information available for this strain. This may be due to the supply level of this strain.
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
|
*Price(s) in US dollars ($)
Weeks of Age Price* Gender Cryorecovery Fee $1900.00
Additional Supply Details
| Pricing for International shipping destinations |
|
*Price(s) in US dollars ($)
Weeks of Age Price* Gender Cryorecovery Fee $2470.00
Additional Supply Details
|
|
|
Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
|
Control Information
| Control | ||
|---|---|---|
| 001976 NOD/ShiLtJ | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
General Terms and Conditions
See Terms of Use
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
Purchasing Information
JAX® Mice Orders
Surgical Services
Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form
Terms of Use
Terms of Use
General Terms and Conditions
Contact information
General inquiries
Contracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice & Services Conditions of Use
“Each recipient institution, including its employees and other researchers under its control (RECIPIENT), of mice or services using mice from The Jackson Laboratory (TJL) agrees that such mice, descendants of those mice derived by inbreeding or crossbreeding, including unmodified derivatives of those mice or their descendants (“MICE”) shall not be: (i) used for any purpose other than the internal research of the RECIPIENT, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services with respect to MICE. Acceptance of MICE from TJL shall be deemed agreement by RECIPIENT to these conditions, and departure from these conditions requires The Jackson Laboratory’s prior written authorization.”No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. THE LABORATORY EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of MICE, products or services, The Jackson Laboratory will, at its option, provide credit or replacement for the MICE or product received or the services provided.
No Liability
In no event shall The Jackson Laboratory, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, products or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of The Jackson Laboratory, its agents or employees. In purchasing or receiving MICE, products or services from The Jackson Laboratory, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges The Jackson Laboratory from all such causes of action or damages, and further agrees to defend and indemnify The Jackson Laboratory from any costs or damages arising out of any third party claims.
MICE and biological materials are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to The Jackson Laboratory’s MICE, products and services. In addition, special terms and conditions of sale of certain MICE, products and services may be set forth separately in The Jackson Laboratory web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, products and services by The Jackson Laboratory, and by its licensees and distributors.
Acceptance of delivery of MICE, products or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on The Jackson Laboratory, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, products services by The Jackson Laboratory.