Description

Strain Information

Former Names RC-5    (Changed: 15-DEC-04 ) Type Recombinant Congenic (Rc); Additional information on Recombinant Congenic Mice. Species laboratory mouse Background Strain NON/ShiLt Donor Strain NZO/HlLt H2 Haplotype z

Appearance
albino
Related Genotype: A/A Tyr^c/Tyr^c

Important Note
September 2004: A recessive head-tilt phenotype has been identified in some mice in this strain and is being bred out, but may be segregating in the mice currently being distributed.

Description
A diabetes-resistant recombinant congenic developed by introgressing selected markers of resistance alleles for all but one known diabesity QTL in the parental strains NZO/HlLt and NON/Lt. The NONcNZO5/LtJ stock has been specifically constructed to exclude 5 NZO-derived and two NON-derived diabetes susceptibility QTL present in the highly diabetes-prone NONcNZO10LtJ recombinant congenic stock. NONcNZO5/LtJ males develop a comparable level of moderate obesity to that developing in the highly diabetes susceptible NONcNZO10/LtJ males, but they do not develop the extreme obesity characteristic of NZO/HlLt. Neither NONcNZO5/LtJ males nor females develop spontaneous type 2 diabetes on a 6% fat-containing diet. Serum insulin and leptin values are close to the NON/Lt parental background range and significantly lower than in NZO/HlLt. Unlike NZO/HlLt, NONcNZO5/LtJ breeds well. Unlike NZO and NONcNZO10/LtJ males, NONcNZO5LtJ males are resistant to adverse hepatic side effects of thiazolidinediones and thus, in combination with NONcNZO10/LtJ mice, may be useful for pharmacogenetic analysis. This strain represents a model of polygenic obesity and may be used as a diabetes resistant control for NONcNZO10/LtJ (Stock No. 004456).

Related Strains

NONcNZO Strains

003668	NONcNZO1/Lt
004456	NONcNZO10/LtJ
003670	NONcNZO3/Lt
003671	NONcNZO4/Lt
003673	NONcNZO6/Lt
003675	NONcNZO8/Lt

View NONcNZO Strains     (6 strains)

Additional Web Information

JAX^® NOTES, Fall 2002; 487. New Polygenic Obesity Mouse Models.

Phenotype

Phenotype Information

View Phenotypic Data

Phenotypic Data

Mouse Phenome Database

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Diabetes and Obesity Research
Obesity Without Diabetes (control for NONcNZO10/LtJ)

Genes & Alleles

Gene & Allele Information

Currently there are no related genes or alleles for this strain.

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Optimizing PCR Protocols

References

References

Selected Reference(s)

Leiter EH; Reifsnyder PC. 2004. Differential levels of diabetogenic stress in two new mouse models of obesity and type 2 diabetes. Diabetes 53 Suppl 1:S4-11. [PubMed: 14749259]  [MGI Ref ID J:109841]

Leiter EH; Reifsnyder PC; Flurkey K; Partke HJ; Junger E; Herberg L. 1998. NIDDM genes in mice: deleterious synergism by both parental genomes contributes to diabetogenic thresholds. Diabetes 47(8):1287-95. [PubMed: 9703330]  [MGI Ref ID J:48957]

Reifsnyder PC; Churchill G; Leiter EH. 2000. Maternal environment and genotype interact to establish diabesity in mice. Genome Res 10(10):1568-78. [PubMed: 11042154]  [MGI Ref ID J:65256]

Reifsnyder PC; Leiter EH. 2002. Deconstructing and reconstructing obesity-induced diabetes (diabesity) in mice. Diabetes 51(3):825-32. [PubMed: 11872687]  [MGI Ref ID J:75024]

Taylor BA; Wnek C; Schroeder D; Phillips SJ. 2001. Multiple obesity QTLs identified in an intercross between the NZO (New Zealand obese) and the SM (small) mouse strains. Mamm Genome 12(2):95-103. [PubMed: 11210195]  [MGI Ref ID J:67838]

Watkins SM; Reifsnyder PR; Pan HJ; German JB; Leiter EH. 2002. Lipid metabolome-wide effects of the PPARgamma agonist rosiglitazone. J Lipid Res 43(11):1809-17. [PubMed: 12401879]  [MGI Ref ID J:109849]

Health & husbandry

Health & Colony Maintenance Information

Currently there no information available for this strain. This may be due to the supply level of this strain.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Supply Details

Standard Supply	Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes	Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 or 1-207-288-5845. This strain is included in the Special Mutant Stock Resource collection.
Important Note	September 2004: A recessive head-tilt phenotype has been identified in some mice in this strain and is being bred out, but may be segregating in the mice currently being distributed.

General Terms and Conditions

See Terms of Use

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Terms of Use

Terms of Use

General Terms and Conditions

Contact information

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JAX^® Mice & Services Conditions of Use

“Each recipient institution, including its employees and other researchers under its control (RECIPIENT), of mice or services using mice from The Jackson Laboratory (TJL) agrees that such mice, descendants of those mice derived by inbreeding or crossbreeding, including unmodified derivatives of those mice or their descendants (“MICE”) shall not be: (i) used for any purpose other than the internal research of the RECIPIENT, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services with respect to MICE. Acceptance of MICE from TJL shall be deemed agreement by RECIPIENT to these conditions, and departure from these conditions requires The Jackson Laboratory’s prior written authorization.”

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