Strain Name: |
NONcNZO5/LtJ |
|---|---|
Stock Number: |
004455 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Former Name |
RC-5 (Changed: 15-DEC-04
) |
Product Information
Strain Details
Type Recombinant Congenic (Rc) Additional information on Recombinant Congenic Mice. Species laboratory mouse Background Strain NON/ShiLt Donor Strain NZO/HlLt H2 Haplotype z Appearance
albino
Related Genotype: A/A Tyrc/TyrcImportant Note
September 2004: A recessive head-tilt phenotype has been identified in some mice in this strain and is being bred out, but may be segregating in the mice currently being distributed.Strain Description
A diabetes-resistant recombinant congenic developed by introgressing selected markers of resistance alleles for all but one known diabesity QTL in the parental strains NZO/HlLt and NON/Lt. The NONcNZO5/LtJ stock has been specifically constructed to exclude 5 NZO-derived and two NON-derived diabetes susceptibility QTL present in the highly diabetes-prone NONcNZO10LtJ recombinant congenic stock. NONcNZO5/LtJ males develop a comparable level of moderate obesity to that developing in the highly diabetes susceptible NONcNZO10/LtJ males, but they do not develop the extreme obesity characteristic of NZO/HlLt. Neither NONcNZO5/LtJ males nor females develop spontaneous type 2 diabetes on a 6% fat-containing diet. Serum insulin and leptin values are close to the NON/Lt parental background range and significantly lower than in NZO/HlLt. Unlike NZO/HlLt, NONcNZO5/LtJ breeds well. Unlike NZO and NONcNZO10/LtJ males, NONcNZO5LtJ males are resistant to adverse hepatic side effects of thiazolidinediones and thus, in combination with NONcNZO10/LtJ mice, may be useful for pharmacogenetic analysis. This strain represents a model of polygenic obesity and may be used as a diabetes resistant control for NONcNZO10/LtJ (Stock No. 004456).
Related Strains
NONcNZO Strains
003668 NONcNZO1/Lt 004456 NONcNZO10/LtJ 003670 NONcNZO3/Lt 003671 NONcNZO4/Lt 003673 NONcNZO6/Lt 003675 NONcNZO8/Lt View NONcNZO Strains (6 strains)
Phenotypic Data
Mouse Phenome Database
Additional Web Information
JAX® NOTES, Fall 2002; 487. New Polygenic Obesity Mouse Models.
Research Applications
This mouse can be used to support research in many areas including:
Diabetes and Obesity Research
Obesity Without Diabetes (control for NONcNZO10/LtJ)
References
Selected Reference(s)
Leiter EH; Reifsnyder PC. 2004. Differential levels of diabetogenic stress in two new mouse models of obesity and type 2 diabetes. Diabetes 53 Suppl 1:S4-11. [PubMed: 14749259] [MGI Ref ID J:109841]
Leiter EH; Reifsnyder PC; Flurkey K; Partke HJ; Junger E; Herberg L. 1998. NIDDM genes in mice: deleterious synergism by both parental genomes contributes to diabetogenic thresholds. Diabetes 47(8):1287-95. [PubMed: 9703330] [MGI Ref ID J:48957]
Reifsnyder PC; Churchill G; Leiter EH. 2000. Maternal environment and genotype interact to establish diabesity in mice. Genome Res 10(10):1568-78. [PubMed: 11042154] [MGI Ref ID J:65256]
Reifsnyder PC; Leiter EH. 2002. Deconstructing and reconstructing obesity-induced diabetes (diabesity) in mice. Diabetes 51(3):825-32. [PubMed: 11872687] [MGI Ref ID J:75024]
Taylor BA; Wnek C; Schroeder D; Phillips SJ. 2001. Multiple obesity QTLs identified in an intercross between the NZO (New Zealand obese) and the SM (small) mouse strains. Mamm Genome 12(2):95-103. [PubMed: 11210195] [MGI Ref ID J:67838]
Watkins SM; Reifsnyder PR; Pan HJ; German JB; Leiter EH. 2002. Lipid metabolome-wide effects of the PPARgamma agonist rosiglitazone. J Lipid Res 43(11):1809-17. [PubMed: 12401879] [MGI Ref ID J:109849]
Price and Supply Information
| Strain Name: | NONcNZO5/LtJ |
| Stock Number: | 004455 |
Price Details
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below |
General Terms and Conditions
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The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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