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Price and Supply Information
General Terms and Conditions	Additional Licensing and Use Restrictions

Former Name	RC-10    (Changed: 15-DEC-04 )
Strain Common Names	RCS-10;

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Product Information

Strain Details

Type Recombinant Congenic (Rc) Additional information on Recombinant Congenic Mice. Mating System Sibling x Sibling         (Female x Male) Species laboratory mouse Background Strain NON/ShiLtJ Donor Strain NZO/HlLt Donating Investigator Edward Leiter,   The Jackson Laboratory H2 Haplotype nb1 Generation N1F11+8 (16-NOV-05)

Appearance
albino
Related Genotype: A/A Tyr^c/Tyr^c

Strain Description
Onset of hyperglycemia occurs between 10-12 on a 10-11% fat (wt/wt) chow diet with greater than 85% diabetic by 18 weeks. Males exhibit increased serum triglycerides, moderate to severe liver steatosis and pancreatic islet atrophy similar to NZO/HlLt males. Serum insulin and leptin values are significantly lower than in NZO/HlLt, and are only moderately elevated above those recorded in NON/ShiLtJ males. Unlike the very obese NZO/HlLt mice, NONcNZO10/LtJ mice do not exhibit hyperphagia or hypercorticism and are much easier to breed. Although NONcNZO10/LtJ males develop only a moderate level of obesity compared to NZO/HlLt males, the interaction with known diabetogenic QTL from the NON/ShiLtJ strain produce an earlier onset and higher prevalence of chronic hyperglycemia than observed in NZO/HlLt males.

NONcNZO10/LtJ is differentially sensitive to adverse hepatic side effects of thiazolidinediones and may be useful for pharmac ogenetic analysis. This strain represents a model of polygenic obesity and obesity-induced diabetes (diabesity).

Note that the diabetes phenotype originally characterized by Dr. Leiter in his research vivarium was performed with mice fed a 6% wt/wt diet. After the strain was rederived it was experimentally determined that it is essential to feed the mice a higher fat diet to force penetrance of the diabetes phenotype.

Strain Development
A recombinant congenic developed by introgressing six known diabesity QTL from the Type 2 diabetes-prone and obese NZO/HlLt inbred strain into the nominally nonobese and diabetes-resistant NON/Lt strain background. NZO-derived QTL include those marked by D1Mit411, D5Mit7, D11Mit261/D11Mit41, D12Mit231 and D15Mit159.

Control Information

	Control
	Please Inquire	The controls recommended for NONcNZO10/LtJ depend on its intended use. The parental line, NON/ShiLtJ (Stock No. 002423), provides a genetic background control (88% homology). On a 10-11% fat diet, which is available for purchase, this strain exhibits moderate obesity and impaired glucose tolerance, but does not develop hyperglycemia. Like NON/ShiLtJ, SWR/J (Stock No. 000689) is a Swiss-derived inbred. SWR/J mice are resistant to diet-induced obesity and do not exhibit impaired glucose tolerance. A third option, NONcNZO5/LtJ (Stock No. 004455), is available only in limited quantities, however, males of this strain exhibit moderate obesity, and both sexes are diabetes resistant.
		This strain is under active development and we would be happy to share unpublished data and work with investigators interested in working with this strain to assist them in the selection of a control appropriate for their study.
Considerations for Choosing Controls
Control Pricing Information for JAX® GEMM® Strains

Colony Maintenance

Diet Information	LabDiet® 5K20

Related Strains

NONcNZO Strains

003668	NONcNZO1/Lt
003670	NONcNZO3/Lt
003671	NONcNZO4/Lt
004455	NONcNZO5/LtJ
003673	NONcNZO6/Lt
003675	NONcNZO8/Lt

View NONcNZO Strains     (6 strains)

Phenotypic Data

Mouse Phenome Database

Additional Web Information

Genetic Quality Control Annual Report
JAX^® NOTES, Fall 2002; 487. New Polygenic Obesity Mouse Models.
JAX^® NOTES, Spring 2005; 497. NONcNZO10/LtJ, a New JAX^® Mice Model for Obesity-Induced Type 2 Diabetes

Animal Health Reports

Room Number           MP19

Research Applications

This mouse can be used to support research in many areas including:

Diabetes and Obesity Research
Hyperglycemia (males)
Obesity With Diabetes (moderate, males)
Obesity Without Diabetes (females)
Type 2 Diabetes (NIDDM) (males)

References

Selected Reference(s)

Leiter EH; Reifsnyder PC. 2004. Differential levels of diabetogenic stress in two new mouse models of obesity and type 2 diabetes. Diabetes 53 Suppl 1:S4-11. [PubMed: 14749259]  [MGI Ref ID J:109841]

Leiter EH; Reifsnyder PC; Flurkey K; Partke HJ; Junger E; Herberg L. 1998. NIDDM genes in mice: deleterious synergism by both parental genomes contributes to diabetogenic thresholds. Diabetes 47(8):1287-95. [PubMed: 9703330]  [MGI Ref ID J:48957]

Reifsnyder PC; Churchill G; Leiter EH. 2000. Maternal environment and genotype interact to establish diabesity in mice. Genome Res 10(10):1568-78. [PubMed: 11042154]  [MGI Ref ID J:65256]

Reifsnyder PC; Leiter EH. 2002. Deconstructing and reconstructing obesity-induced diabetes (diabesity) in mice. Diabetes 51(3):825-32. [PubMed: 11872687]  [MGI Ref ID J:75024]

Taylor BA; Wnek C; Schroeder D; Phillips SJ. 2001. Multiple obesity QTLs identified in an intercross between the NZO (New Zealand obese) and the SM (small) mouse strains. Mamm Genome 12(2):95-103. [PubMed: 11210195]  [MGI Ref ID J:67838]

Watkins SM; Reifsnyder PR; Pan HJ; German JB; Leiter EH. 2002. Lipid metabolome-wide effects of the PPARgamma agonist rosiglitazone. J Lipid Res 43(11):1809-17. [PubMed: 12401879]  [MGI Ref ID J:109849]

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Price and Supply Information

Strain Name:	NONcNZO10/LtJ
Stock Number:	004456

Price Details

IMPORTANT NOTE: Prices are based on shipping destination. The shipping destinations are:

• USA, Canada and Mexico
• International

*Pricing for Shipping Destination selected:

        USA, Canada and Mexico

Price(s) in US dollars ($)		Genotype(s) Provided
3-5 weeks	$74.40		Female
6 weeks	$78.30		Female
7 weeks	$82.20		Female
8 weeks	$86.10		Female
9 weeks	$90.00		Female
10 weeks	$93.90		Female
11 weeks	$97.80		Female
12 weeks	$101.70		Female
3-5 weeks	$74.40		Male
6 weeks	$78.30		Male
7 weeks	$82.20		Male
8 weeks	$86.10		Male
9 weeks	$90.00		Male
10 weeks	$93.90		Male
11 weeks	$97.80		Male
12 weeks	$101.70		Male

Supply Details

Standard Supply	Level 2. Up to 100 mice. Larger quantities or custom orders arranged upon request.
Supply Notes	Histology and Tissue Collection Services are available for all JAX® Mice strains. For more information, please contact Customer Service at orderquest@jax.org or 1-800-422-6423. Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available. Strains that must be genotyped are not available until five to seven weeks of age. Genomic DNA is available for this strain from the Mouse DNA Resource.
Licensing	See General Terms and Conditions below for Licensing and Use Restrictions
Control Information	View Control Information in Strain Details. View Control Pricing Information for JAX® Strains.

General Terms and Conditions

View JAX^® Mice & Services Conditions of Use.

For additional Licensing and Use Restrictions view the link(s) below:
- Notice regarding NONcNZO10/LtJ Female
- Notice regarding NONcNZO10/LtJ Male

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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