Strain Name:

B6C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax

Availability:

Repository- Live     Available at the JAX MMRRC

Use Restrictions Apply, see Terms of Use
This strain is now distributed by the Mutant Mouse Regional Resource Center. Please refer to the Mutant Mouse Regional Resource Center (MMRRC) for ordering information and strain details on B6C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax MMRRC Stock Number 034829.
As a designated MMRRC center, The Jackson Laboratory will continue to distribute these mice at the same high health and
quality standards but ordering is exclusively provided through the MMRRC.
Double transgenic (formerly JAX Stock No. 004462) mice express a chimeric mouse/human amyloid precursor protein (Mo/HuAPP695swe) and a mutant human presenilin 1 (PS1-dE9) both directed to CNS neurons. Both mutations are associated with early-onset Alzheimer's disease.

Description

Strain Information

Former Names B6C3-Tg(APPswe,PSEN1dE9)85Dbo/J    (Changed: 10-AUG-11 )
B6C3-Tg(APPswe, PSEN1dE9)85Dbo/J    (Changed: 01-FEB-06 )
B6C3-Tg(APP695)85Dbo Tg(PSEN1)85Dbo    (Changed: 15-DEC-04 )
B6C3-Tg(APP695)85Dbo Tg(PSEN1)85Dbo/J    (Changed: 15-DEC-04 )
Mo/Hu APPswe PS1dE9    (Changed: 15-DEC-04 )
Type Mutant Strain; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
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Mating System+/+ sibling x Hemizygote         (Female x Male)   28-OCT-13
Specieslaboratory mouse
 
Donating InvestigatorDr. David R Borchelt,   University of Florida

Description
Double transgenic mice express a chimeric mouse/human amyloid precursor protein (Mo/HuAPP695swe) and a mutant human presenilin 1 (PS1-dE9) both directed to CNS neurons. Both mutations are associated with early-onset Alzheimer's disease. The "humanized" Mo/HuAPP695swe transgene allows the mice to secrete a human A-beta peptide. Both the transgenic peptide and holoprotein can be detected by antibodies specific for human sequence within this region (Signet Laboratories' monoclonal 6E10 antibody). The included Swedish mutations (K595N/M596L) elevate the amount of A-beta produced from the transgene by favoring processing through the beta-secretase pathway. This "humanized" Mo/HuAPP695swe protein is immunodetected in whole brain protein homogenates. The transgenic mutant human presenilin protein (PS1-dE9), which in high levels displaces detectable endogenous mouse protein, is also immunodetected in whole brain protein homogenates. The donating investigator reports that transgenic mice develop beta-amyloid deposits in brain by six to seven months of age. These animals also display a slight alteration in their tail phenotype (e.g. kinked tail) that is believed to be due to the mixed genetic background of the strain and is not related to transgene expression. Hemizygous mice on the C57BL/6 background (N9B6) exhibit a high incidence of seizures, as detected by video-EEG. 25% of transgenic mice, 3 to 3.5 months in age, exhibit at least 1 seizure. By 4.5 months of age, seizure incidence increases to 55%. 10-15% mortality is reported for transgenic mice on the congenic (N9) C57BL/6 background (Minkeviciene et al. J Neurosci. 2009). Hemizygous mice, on the congenic C57BL/6J background (N13), 17-18 weeks in age, exhibit epileptiform discharges as detected by video-EEG. Mortality was 38% (6/16) and some mutant mice experienced spontaneous seizures during the experiments. Antiepileptic drugs (carbamazepine, phenytoin, valproate) reduce the frequency of spontaneous electrographic epileptiform discharges (Ziyatdinova et al. Epilepsy Res 2011). These mice may be useful in studies of neurological disorders of the brain, specifically Alzheimer's disease, amyloid plaque formation, and aging.

This strain does not carry the retinal degeneration allele Pde6brd1.

Development
Two expression plasmids (Mo/HuAPP695swe and PS1-dE9) were designed to each be controlled by independent mouse prion protein (PrP) promoter elements, directing transgene expression predominantly to CNS neurons. The Mo/HuAPP695swe transgene expresses a “humanized” mouse amyloid beta (A4) precursor protein gene modified at three amino acids to reflect the human residues and further modified to contain the K595N/M596L mutations linked to familial Alzheimers. The PS1-dE9 transgene expresses a mutant human presenilin 1 carrying the exon-9-deleted variant (PSEN1dE9) associated with familial Alzheimer's disease. These constructs were coinjected into B6C3HF2 pronuclei and insertion of the transgenes occured at a single locus. Founder line 85 was obtained and the resulting colony was maintained as a hemizygote by crossing transgenic mice to B6C3F1/J mice.

Control Information

  Control
   Noncarrier
 
  Considerations for Choosing Controls

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Alzheimer's Disease Models
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006409   129S1.129(Cg)-Tg(APPSw)40Btla/Mmjax
008077   129S1/Sv-Bchetm1Loc/J
016198   129S6.Cg-Tg(Camk2a-tTA)1Mmay/JlwsJ
014556   129S6/SvEv-Apoetm4Mae/J
006555   A.129(B6)-Tg(APPSw)40Btla/Mmjax
005708   B6.129-Apbb1tm1Quhu/J
004714   B6.129-Bace1tm1Pcw/J
004098   B6.129-Klc1tm1Gsn/J
004193   B6.129-Psen1tm1Mpm/J
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008087   B6.129S1-Bchetm1Loc/J
002509   B6.129S2-Plautm1Mlg/J
005301   B6.129S2-Tg(APP)8.9Btla/J
004163   B6.129S4-Cdk5r1tm1Lht/J
010959   B6.129S4-Grk5tm1Rjl/J
010960   B6.129S4-Grk5tm2Rjl/J
002213   B6.129S4-Ngfrtm1Jae/J
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007251   B6.129X1-Mapttm1Hnd/J
013040   B6.Cg-Apoetm1Unc Ins2Akita/J
005642   B6.Cg-Clutm1Jakh/J
005491   B6.Cg-Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
009126   B6.Cg-Nos2tm1Lau Tg(Thy1-APPSwDutIowa)BWevn/Mmjax
005866   B6.Cg-Tg(APP695)3Dbo Tg(PSEN1dE9)S9Dbo/Mmjax
008730   B6.Cg-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax
005864   B6.Cg-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax
007575   B6.Cg-Tg(CAG-Ngb,-EGFP)1Dgrn/J
016197   B6.Cg-Tg(CAG-OTC/CAT)4033Prab/J
005855   B6.Cg-Tg(Camk2a-Prkaca)426Tabe/J
007004   B6.Cg-Tg(Camk2a-tTA)1Mmay/DboJ
004996   B6.Cg-Tg(DBH-Gal)1923Stei/J
007673   B6.Cg-Tg(Gad1-EGFP)3Gfng/J
004662   B6.Cg-Tg(PDGFB-APP)5Lms/J
006293   B6.Cg-Tg(PDGFB-APPSwInd)20Lms/2Mmjax
006006   B6.Cg-Tg(Prnp-APP)A-2Dbo/J
008596   B6.Cg-Tg(Prnp-Abca1)EHol/J
006005   B6.Cg-Tg(Prnp-App/APPswe)E1-2Dbo/Mmjax
007180   B6.Cg-Tg(Prnp-ITM2B/APP695*40)1Emcg/J
007182   B6.Cg-Tg(Prnp-ITM2B/APP695*42)A12Emcg/J
005999   B6.Cg-Tg(SBE/TK-luc)7Twc/J
012597   B6.Cg-Tg(Thy1-COL25A1)861Yfu/J
007051   B6.Cg-Tg(tetO-APPSwInd)102Dbo/Mmjax
007052   B6.Cg-Tg(tetO-APPSwInd)107Dbo/Mmjax
007049   B6.Cg-Tg(tetO-APPSwInd)885Dbo/Mmjax
009337   B6.FVB-Tg(Prnp-RTN3)2Yanr/J
006394   B6;129-Apba2tm1Sud Apba3tm1Sud Apba1tm1Sud/J
008364   B6;129-Chattm1(cre/ERT)Nat/J
008476   B6;129-Ncstntm1Sud/J
004807   B6;129-Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa/Mmjax
007605   B6;129P-Psen1tm1Vln/J
005618   B6;129P2-Bace2tm1Bdes/J
008333   B6;129P2-Dldtm1Ptl/J
002596   B6;129P2-Nos2tm1Lau/J
003822   B6;129S-Psen1tm1Shn/J
012639   B6;129S4-Mapttm3(HDAC2)Jae/J
012869   B6;129S6-Apbb2tm1Her/J
006410   B6;129S6-Chattm2(cre)Lowl/J
005993   B6;129S6-Pcsk9tm1Jdh/J
008636   B6;C-Tg(Prnp-APP695*/EYFP)49Gsn/J
007002   B6;C3-Tg(Prnp-ITM2B/APP695*42)A12Emcg/Mmjax
008169   B6;C3-Tg(Prnp-MAPT*P301S)PS19Vle/J
000231   B6;C3Fe a/a-Csf1op/J
008850   B6;SJL-Tg(Mt1-LDLR)93-4Reh/AgnJ
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003741   B6D2-Tg(Prnp-MAPT)43Vle/J
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018957   B6N.129S6(B6)-Chattm2(cre)Lowl/J
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002328   C.129S2-Plautm1Mlg/J
003375   C3B6-Tg(APP695)3Dbo/Mmjax
005087   C57BL/6-Tg(Camk2a-IDE)1Selk/J
005086   C57BL/6-Tg(Camk2a-MME)3Selk/J
008833   C57BL/6-Tg(Camk2a-UBB)3413-1Fwvl/J
007027   C57BL/6-Tg(Thy1-APPSwDutIowa)BWevn/Mmjax
010800   C57BL/6-Tg(Thy1-PTGS2)300Kand/J
010703   C57BL/6-Tg(Thy1-PTGS2)303Kand/J
005706   C57BL/6-Tg(tetO-CDK5R1/GFP)337Lht/J
006618   C57BL/6-Tg(tetO-COX8A/EYFP)1Ksn/J
007677   CB6-Tg(Gad1-EGFP)G42Zjh/J
007072   CByJ.129P2(B6)-Nos2tm1Lau/J
006472   D2.129(B6)-Tg(APPSw)40Btla/Mmjax
007067   D2.129P2(B6)-Apoetm1Unc/J
013719   D2.Cg-Apoetm1Unc Ins2Akita/J
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004779   STOCK Mapttm1(EGFP)Klt/J
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View Alzheimer's Disease Models     (109 strains)

Strains carrying   Tg(APPswe,PSEN1dE9)85Dbo allele
005864   B6.Cg-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax
View Strains carrying   Tg(APPswe,PSEN1dE9)85Dbo     (1 strain)

View Strains carrying other alleles of APP     (15 strains)

View Strains carrying other alleles of PSEN1     (5 strains)

View Strains carrying other alleles of Prn     (4 strains)

Additional Web Information

Visit the Alzheimer's Disease Mouse Model Resource site for helpful information on Alzheimer's Disease and research resources.

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Characteristics of this human disease are associated with transgenes and other mutation types in the mouse.
Alzheimer Disease 3
Alzheimer Disease; AD
- Potential model based on transgenic expression of an ortholog of a human gene that is associated with this disease. Phenotypic similarity to the human disease has not been tested.
Acne Inversa, Familial, 3; ACNINV3   (PSEN1)
Cardiomyopathy, Dilated, 1u; CMD1U   (PSEN1)
Cerebral Amyloid Angiopathy, App-Related   (APP)
Frontotemporal Dementia; FTD   (PSEN1)
Pick Disease of Brain   (PSEN1)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Tg(APPswe,PSEN1dE9)85Dbo/0

        involves: C3H/HeJ * C57BL/6J
  • nervous system phenotype
  • amyloid beta deposits
    • plaques are abundant in hippocampus and cortex by 9 months of age   (MGI Ref ID J:87691)
    • occasional deposits can be found in mice as young as 6 months of age   (MGI Ref ID J:87691)
    • ratio of amyloid beta peptide 40:42 is 0.50:1   (MGI Ref ID J:87691)
    • deposits observed in hippocampus by 6 months of age   (MGI Ref ID J:139071)
  • reduced long term potentiation
    • transient long term potentiation (t-LTP) is reduced in transgenics and is age-independent   (MGI Ref ID J:139071)
  • behavior/neurological phenotype
  • abnormal spatial reference memory
    • transgenic mice exhibit a 4-5% higher preference for the arm of the radial arm water maze that held the platform on the previous day   (MGI Ref ID J:139071)
    • 13 month old transgenic mice commit more errors in the water maze than controls, at 7 months of age both groups test similarly   (MGI Ref ID J:139071)
  • impaired coordination
    • 14 month old transgenic mice exhibit a reduced ability to maintain balance on a rotarod   (MGI Ref ID J:139071)
  • growth/size/body phenotype
  • decreased body weight
    • at 14 months, transgenics weigh less than controls   (MGI Ref ID J:139071)
  • homeostasis/metabolism phenotype
  • amyloid beta deposits
    • plaques are abundant in hippocampus and cortex by 9 months of age   (MGI Ref ID J:87691)
    • occasional deposits can be found in mice as young as 6 months of age   (MGI Ref ID J:87691)
    • ratio of amyloid beta peptide 40:42 is 0.50:1   (MGI Ref ID J:87691)
    • deposits observed in hippocampus by 6 months of age   (MGI Ref ID J:139071)

Tg(APPswe,PSEN1dE9)85Dbo/0

        B6C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax
  • nervous system phenotype
  • amyloid beta deposits
    • sparse deposits observed at 21 weeks of age, however, numerous deposits are observed at 45 and 60 weeks   (MGI Ref ID J:113199)
    • deposits are more extensive in females   (MGI Ref ID J:113199)
    • level of brain amyloid beta peptide 42 is predominant over 40; levels increase dramatically after 20 weeks of age   (MGI Ref ID J:113199)
    • senile plaques detected by thioflavin S or the anti-amyloid beta antibody, 3D6, as early as 4 months of age   (MGI Ref ID J:113200)
    • plaques are restricted to cortex and hippocampus at time points up to 12 months of age   (MGI Ref ID J:113200)
    • plaques increase in number and size over time   (MGI Ref ID J:113200)
    • exhibits an overall increase in soluble and insoluble amyloid beta peptide 40 and 42 between 4 and 12 months   (MGI Ref ID J:113200)
    • insoluble amyloid beta42 is increased 2-fold in cerebrum of sucrose-fed mice as compared to water-fed control   (MGI Ref ID J:129021)
    • total amyloid beta levels are increased by 3.6 fold in sucrose fed mice   (MGI Ref ID J:129021)
    • amyloid beta deposition is increased by 2.9-fold as determined by immunohistochemical and morphometric analysis in sucrose-fed mice   (MGI Ref ID J:129021)
  • cerebral amyloid angiopathy
    • exhibits progressive increase in cerebral amyloid angiopathy as early as 6 months   (MGI Ref ID J:113200)
    • amyloid deposition is observed in leptomeningeal vasculature   (MGI Ref ID J:113200)
  • behavior/neurological phenotype
  • abnormal spatial learning
    • transgenic mice fed sucrose water failed to learn Morris water maze test after 5 days of training   (MGI Ref ID J:129021)
    • water-fed transgenic mice retained some learning ability over 5 day test period, but did not perform as well in the water maze test as non-transgenic controls   (MGI Ref ID J:129021)
  • increased fluid intake
    • mice fed sucrose water exhibited increased water consumption   (MGI Ref ID J:129021)
  • homeostasis/metabolism phenotype
  • amyloidosis   (MGI Ref ID J:129021)
    • amyloid beta deposits
      • sparse deposits observed at 21 weeks of age, however, numerous deposits are observed at 45 and 60 weeks   (MGI Ref ID J:113199)
      • deposits are more extensive in females   (MGI Ref ID J:113199)
      • level of brain amyloid beta peptide 42 is predominant over 40; levels increase dramatically after 20 weeks of age   (MGI Ref ID J:113199)
      • senile plaques detected by thioflavin S or the anti-amyloid beta antibody, 3D6, as early as 4 months of age   (MGI Ref ID J:113200)
      • plaques are restricted to cortex and hippocampus at time points up to 12 months of age   (MGI Ref ID J:113200)
      • plaques increase in number and size over time   (MGI Ref ID J:113200)
      • exhibits an overall increase in soluble and insoluble amyloid beta peptide 40 and 42 between 4 and 12 months   (MGI Ref ID J:113200)
      • insoluble amyloid beta42 is increased 2-fold in cerebrum of sucrose-fed mice as compared to water-fed control   (MGI Ref ID J:129021)
      • total amyloid beta levels are increased by 3.6 fold in sucrose fed mice   (MGI Ref ID J:129021)
      • amyloid beta deposition is increased by 2.9-fold as determined by immunohistochemical and morphometric analysis in sucrose-fed mice   (MGI Ref ID J:129021)
    • cerebral amyloid angiopathy
      • exhibits progressive increase in cerebral amyloid angiopathy as early as 6 months   (MGI Ref ID J:113200)
      • amyloid deposition is observed in leptomeningeal vasculature   (MGI Ref ID J:113200)
  • impaired glucose tolerance
    • mice fed sucrose water displayed an impaired glucose tolerance as compared to water-fed control   (MGI Ref ID J:129021)
  • increased circulating cholesterol level
    • total cholesterol, but not HDL, levels are increased 30% in mice fed sucrose water as compared to water-fed control   (MGI Ref ID J:129021)
  • increased circulating insulin level
    • fasting plasma insulin levels are increased 3 fold in mice fed sucrose water as compared to water-fed control   (MGI Ref ID J:129021)
  • increased circulating triglyceride level
    • elevated plasma triglyceride levels observed in females at 15 weeks of age   (MGI Ref ID J:113199)
  • cardiovascular system phenotype
  • vasculature congestion   (MGI Ref ID J:113200)
  • growth/size/body phenotype
  • increased body weight
    • mice fed sucrose water consistently gained weight over study time period (2 months- 8 months)   (MGI Ref ID J:129021)
    • sucrose-fed mice increased body weight by 17% over water-fed controls   (MGI Ref ID J:129021)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Tg(APPswe,PSEN1dE9)85Dbo/0

        involves: C3H * C57BL/6
  • nervous system phenotype
  • *normal* nervous system phenotype
    • striatal volume is similar in both transgenic and wild-type at either 6 or 12 months of age   (MGI Ref ID J:145530)
    • abnormal medium spiny neuron morphology
      • nuclei of medium spiny stellate neurons in both 6 and 12 month old transgenics are smaller and darker than wild-type   (MGI Ref ID J:145530)
    • decreased neuron number
      • numbers of neurons are reduced in striatum of 12, but not 6, month old transgenics   (MGI Ref ID J:145530)
    • neuron degeneration
      • numbers of neurons are reduced in striatum of 12, but not 6, month old transgenics   (MGI Ref ID J:145530)
      • reduced neuron density is observed in striatum of 12, but not 6, month old transgenics   (MGI Ref ID J:145530)
  • homeostasis/metabolism phenotype
  • *normal* homeostasis/metabolism phenotype
    • mutants exhibit normal body weight, blood glucose, plasma insulin levels, nonfasting blood glucose and nonfasting plasma insulin, and normal glucose and insulin tolerance, indicating normal glucose homeostasis and insulin sensitivity   (MGI Ref ID J:186924)
    • amyloidosis
      • increase in circulating amyloid beta protein levels   (MGI Ref ID J:186924)

Tg(APPswe,PSEN1dE9)85Dbo/0

        B6.Cg-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax
  • mortality/aging
  • premature death
    • about 40% of mice are lost by 12 months of age   (MGI Ref ID J:160557)
  • behavior/neurological phenotype
  • abnormal spatial learning
    • 6 month old mutants exhibit slower visuospatial learning than control mice   (MGI Ref ID J:172426)
    • in the visuospatial re-learning test performed at 9, 11, 13, 15, and 18 months of age, mutants exhibit a decrease in the speed of re-learning the task compared to controls   (MGI Ref ID J:172426)
    • severely impaired performance in a morris water maze with much longer latencies to reach a hidden platform   (MGI Ref ID J:160557)
    • performance in a morris water maze declines between 3 and 12 months of age   (MGI Ref ID J:160557)
  • impaired passive avoidance behavior   (MGI Ref ID J:160557)
  • nervous system phenotype
  • amyloid beta deposits   (MGI Ref ID J:160557)
  • astrocytosis   (MGI Ref ID J:160557)
  • axon degeneration
    • axon degeneration and synapse loss   (MGI Ref ID J:160557)
  • taste/olfaction phenotype
  • *normal* taste/olfaction phenotype
    • mutants do not exhibit Alzheimer's disease-related impairments in olfactory performance in tests based on an operant conditioning procedure and in tests based on a habituation/dishabituation procedure   (MGI Ref ID J:172426)
  • homeostasis/metabolism phenotype
  • amyloid beta deposits   (MGI Ref ID J:160557)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Neurobiology Research
Alzheimer's Disease
      APP and PSEN1 mutants
      Presenilin mutants
      strains expressing mutant APP
Behavioral and Learning Defects
Epilepsy
      electroconvulsive seizures
Neurodegeneration

APP related

Neurobiology Research
Neurodegeneration

Tg(APPswe,PSEN1dE9)85Dbo related

Neurobiology Research
Alzheimer's Disease

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Tg(APPswe,PSEN1dE9)85Dbo
Allele Name transgene insertion 85, David R Borchelt
Allele Type Transgenic (Inserted expressed sequence)
Common Name(s) APP-PS1; APP/PS1; APPswe/PS1dE9; APPswe/PS1deltaE9; APdE9; Mo/Hu APPswe PS1dE9;
Mutation Made ByDr. David Borchelt,   University of Florida
Strain of Origin(C57BL/6 x C3H)F2
Expressed Gene APP, amyloid beta (A4) precursor protein, human
Expressed Gene PSEN1, presenilin 1, human
Promoter Prn, prion protein gene complex, mouse, laboratory
General Note Mice carrying this double transgene develop beta-amyloid deposits in the brain by 6 to 7 months of age.
Molecular Note Two transgenes inserted at a single locus. Each transgene is controlled by the mouse prion promoter and contains a cDNA sequence. In one transgene the cDNA encodes a chimeric amyloid beta (A4) precursor protein (APPswe). In the second transgene the cDNA encodes the "DeltaE9" mutation of human presenilin 1. The DeltaE9 mutation of the human presenilin 1 gene is a deletion of exon 9 and corresponds to a form of early-onset Alzheimer's disease. The amyloid beta precursor protein coding sequences were altered by replacing mouse sequence encoding three amino acids of the A-beta domain with the human coding sequence for these residues. The chimeric amyloid beta (A4) precursor protein sequence was then further modified to encode the Swedish mutations K595N/M596L found in human. Both the transgenic peptide and holoprotein are detected by Signet Laboratories' monoclonal 6E10 antibody, which is specific for human sequence within this region. Human presenilin protein, which in high levels displaces detectable endogenous mouse protein, is immunodetected in the double transgenic mouse in whole brain protein homogenates. Human amyloid precursor protein is also immunodetected in these mice in whole brain protein homogenates. [MGI Ref ID J:78664]
 
 
 

Genotyping

Genotyping Information

Genotyping Protocols

Generic Tg(APP), Standard PCR
Tg(PSEN1), Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Jankowsky JL; Fadale DJ; Anderson J; Xu GM; Gonzales V; Jenkins NA; Copeland NG; Lee MK; Younkin LH; Wagner SL; Younkin SG; Borchelt DR. 2004. Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase. Hum Mol Genet 13(2):159-70. [PubMed: 14645205]  [MGI Ref ID J:87691]

Jankowsky JL; Slunt HH; Ratovitski T; Jenkins NA; Copeland NG; Borchelt DR. 2001. Co-expression of multiple transgenes in mouse CNS: a comparison of strategies. Biomol Eng 17(6):157-65. [PubMed: 11337275]  [MGI Ref ID J:78664]

Reiserer RS; Harrison FE; Syverud DC; McDonald MP. 2007. Impaired spatial learning in the APP + PSEN1DeltaE9 bigenic mouse model of Alzheimer's disease. Genes Brain Behav 6(1):54-65. [PubMed: 17233641]  [MGI Ref ID J:116798]

Additional References

Fukui H; Diaz F; Garcia S; Moraes CT. 2007. Cytochrome c oxidase deficiency in neurons decreases both oxidative stress and amyloid formation in a mouse model of Alzheimer's disease Proc Natl Acad Sci U S A 104(35):14163-8. [PubMed: 17715058]  [MGI Ref ID J:123812]

Sood A; Warren Beach J; Webster SJ; Terry AV; Buccafusco JJ. 2007. The effects of JWB1-84-1 on memory-related task performance by amyloid Abeta transgenic mice and by young and aged monkeys. Neuropharmacology 53(5):588-600. [PubMed: 17698153]  [MGI Ref ID J:124366]

Tg(APPswe,PSEN1dE9)85Dbo related

Ansoleaga B; Garcia-Esparcia P; Llorens F; Moreno J; Aso E; Ferrer I. 2013. Dysregulation of brain olfactory and taste receptors in AD, PSP and CJD, and AD-related model. Neuroscience 248C:369-382. [PubMed: 23817016]  [MGI Ref ID J:207052]

Bakalash S; Pham M; Koronyo Y; Salumbides BC; Kramerov A; Seidenberg H; Berel D; Black KL; Koronyo-Hamaoui M. 2011. Egr1 expression is induced following glatiramer acetate immunotherapy in rodent models of glaucoma and Alzheimer's disease. Invest Ophthalmol Vis Sci 52(12):9033-46. [PubMed: 21969301]  [MGI Ref ID J:189462]

Bao XQ; Li N; Wang T; Kong XC; Tai WJ; Sun H; Zhang D. 2013. FLZ alleviates the memory deficits in transgenic mouse model of Alzheimer's disease via decreasing beta-amyloid production and tau hyperphosphorylation. PLoS One 8(11):e78033. [PubMed: 24223757]  [MGI Ref ID J:209326]

Barbero-Camps E; Fernandez A; Baulies A; Martinez L; Fernandez-Checa JC; Colell A. 2014. Endoplasmic Reticulum Stress Mediates Amyloid beta Neurotoxicity via Mitochondrial Cholesterol Trafficking. Am J Pathol 184(7):2066-81. [PubMed: 24815354]  [MGI Ref ID J:211660]

Barbero-Camps E; Fernandez A; Martinez L; Fernandez-Checa JC; Colell A. 2013. APP/PS1 mice overexpressing SREBP-2 exhibit combined Abeta accumulation and tau pathology underlying Alzheimer's disease. Hum Mol Genet 22(17):3460-76. [PubMed: 23648430]  [MGI Ref ID J:199130]

Bennett L; Kersaitis C; Macaulay SL; Munch G; Niedermayer G; Nigro J; Payne M; Sheean P; Vallotton P; Zabaras D; Bird M. 2013. Vitamin D2-enriched button mushroom (Agaricus bisporus) improves memory in both wild type and APPswe/PS1dE9 transgenic mice. PLoS One 8(10):e76362. [PubMed: 24204618]  [MGI Ref ID J:209189]

Bernardo A; Harrison FE; McCord M; Zhao J; Bruchey A; Davies SS; Jackson Roberts L 2nd; Mathews PM; Matsuoka Y; Ariga T; Yu RK; Thompson R; McDonald MP. 2009. Elimination of GD3 synthase improves memory and reduces amyloid-beta plaque load in transgenic mice. Neurobiol Aging 30(11):1777-91. [PubMed: 18258340]  [MGI Ref ID J:152957]

Bero AW; Yan P; Roh JH; Cirrito JR; Stewart FR; Raichle ME; Lee JM; Holtzman DM. 2011. Neuronal activity regulates the regional vulnerability to amyloid-beta deposition. Nat Neurosci 14(6):750-6. [PubMed: 21532579]  [MGI Ref ID J:173925]

Bie B; Wu J; Yang H; Xu JJ; Brown DL; Naguib M. 2014. Epigenetic suppression of neuroligin 1 underlies amyloid-induced memory deficiency. Nat Neurosci 17(2):223-31. [PubMed: 24441681]  [MGI Ref ID J:207977]

Bollen E; Vanmierlo T; Akkerman S; Wouters C; Steinbusch HM; Prickaerts J. 2013. 7,8-Dihydroxyflavone improves memory consolidation processes in rats and mice. Behav Brain Res 257:8-12. [PubMed: 24070857]  [MGI Ref ID J:202462]

Bosomworth HJ; Adlard PA; Ford D; Valentine RA. 2013. Altered expression of ZnT10 in Alzheimer's disease brain. PLoS One 8(5):e65475. [PubMed: 23741496]  [MGI Ref ID J:200782]

Burdo JR; Chen Q; Calcutt NA; Schubert D. 2009. The pathological interaction between diabetes and presymptomatic Alzheimer's disease. Neurobiol Aging 30(12):1910-7. [PubMed: 18372080]  [MGI Ref ID J:155161]

Burgess BL; McIsaac SA; Naus KE; Chan JY; Tansley GH; Yang J; Miao F; Ross CJ; van Eck M; Hayden MR; van Nostrand W; St George-Hyslop P; Westaway D; Wellington CL. 2006. Elevated plasma triglyceride levels precede amyloid deposition in Alzheimer's disease mouse models with abundant A beta in plasma. Neurobiol Dis 24(1):114-27. [PubMed: 16899370]  [MGI Ref ID J:113199]

Butler D; Hwang J; Estick C; Nishiyama A; Kumar SS; Baveghems C; Young-Oxendine HB; Wisniewski ML; Charalambides A; Bahr BA. 2011. Protective effects of positive lysosomal modulation in Alzheimer's disease transgenic mouse models. PLoS One 6(6):e20501. [PubMed: 21695208]  [MGI Ref ID J:174789]

Butovsky O; Kunis G; Koronyo-Hamaoui M; Schwartz M. 2007. Selective ablation of bone marrow-derived dendritic cells increases amyloid plaques in a mouse Alzheimer's disease model. Eur J Neurosci 26(2):413-6. [PubMed: 17623022]  [MGI Ref ID J:127277]

Camboni M; Wang CM; Miranda C; Yoon JH; Xu R; Zygmunt D; Kaspar BK; Martin PT. 2013. Active and passive immunization strategies based on the SDPM1 peptide demonstrate pre-clinical efficacy in the APPswePSEN1dE9 mouse model for Alzheimer's disease. Neurobiol Dis 62C:31-43. [PubMed: 24021662]  [MGI Ref ID J:201828]

Cao D; Lu H; Lewis TL; Li L. 2007. Intake of sucrose-sweetened water induces insulin resistance and exacerbates memory deficits and amyloidosis in a transgenic mouse model of Alzheimer disease. J Biol Chem 282(50):36275-82. [PubMed: 17942401]  [MGI Ref ID J:129021]

Chakravarthy B; Menard M; Brown L; Hewitt M; Atkinson T; Whitfield J. 2013. A synthetic peptide corresponding to a region of the human pericentriolar material 1 (PCM-1) protein binds beta-amyloid (Abeta1-42 ) oligomers. J Neurochem 126(3):415-24. [PubMed: 23432034]  [MGI Ref ID J:199628]

Chen L; Choi JJ; Choi YJ; Hennig B; Toborek M. 2012. HIV-1 Tat-induced cerebrovascular toxicity is enhanced in mice with amyloid deposits. Neurobiol Aging 33(8):1579-90. [PubMed: 21764480]  [MGI Ref ID J:188199]

Chen SQ; Cai Q; Shen YY; Wang PJ; Teng GJ; Zhang W; Zang FC. 2012. Age-related changes in brain metabolites and cognitive function in APP/PS1 transgenic mice. Behav Brain Res 235(1):1-6. [PubMed: 22828014]  [MGI Ref ID J:193519]

Cheng D; Logge W; Low JK; Garner B; Karl T. 2013. Novel behavioural characteristics of the APP(Swe)/PS1DeltaE9 transgenic mouse model of Alzheimer's disease. Behav Brain Res 245:120-7. [PubMed: 23419740]  [MGI Ref ID J:197461]

Cheng S; Cao D; Hottman DA; Yuan L; Bergo MO; Li L. 2013. Farnesyltransferase haplodeficiency reduces neuropathology and rescues cognitive function in a mouse model of Alzheimer disease. J Biol Chem 288(50):35952-60. [PubMed: 24136196]  [MGI Ref ID J:207213]

Cherry JD; Liu B; Frost JL; Lemere CA; Williams JP; Olschowka JA; O'Banion MK. 2012. Galactic cosmic radiation leads to cognitive impairment and increased abeta plaque accumulation in a mouse model of Alzheimer's disease. PLoS One 7(12):e53275. [PubMed: 23300905]  [MGI Ref ID J:195722]

Choi SH; Leight SN; Lee VM; Li T; Wong PC; Johnson JA; Saraiva MJ; Sisodia SS. 2007. Accelerated Abeta deposition in APPswe/PS1deltaE9 mice with hemizygous deletions of TTR (transthyretin). J Neurosci 27(26):7006-10. [PubMed: 17596449]  [MGI Ref ID J:122976]

Choi SW; Gerencser AA; Ng R; Flynn JM; Melov S; Danielson SR; Gibson BW; Nicholls DG; Bredesen DE; Brand MD. 2012. No consistent bioenergetic defects in presynaptic nerve terminals isolated from mouse models of Alzheimer's disease. J Neurosci 32(47):16775-84. [PubMed: 23175831]  [MGI Ref ID J:192812]

Cohen E; Paulsson JF; Blinder P; Burstyn-Cohen T; Du D; Estepa G; Adame A; Pham HM; Holzenberger M; Kelly JW; Masliah E; Dillin A. 2009. Reduced IGF-1 signaling delays age-associated proteotoxicity in mice. Cell 139(6):1157-69. [PubMed: 20005808]  [MGI Ref ID J:157007]

Couch BA; Kerrisk ME; Kaufman AC; Nygaard HB; Strittmatter SM; Koleske AJ. 2013. Delayed amyloid plaque deposition and behavioral deficits in outcrossed AbetaPP/PS1 mice. J Comp Neurol 521(6):1395-408. [PubMed: 23047754]  [MGI Ref ID J:195179]

Cramer PE; Cirrito JR; Wesson DW; Lee CY; Karlo JC; Zinn AE; Casali BT; Restivo JL; Goebel WD; James MJ; Brunden KR; Wilson DA; Landreth GE. 2012. ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models. Science 335(6075):1503-6. [PubMed: 22323736]  [MGI Ref ID J:181688]

Crouch PJ; Hung LW; Adlard PA; Cortes M; Lal V; Filiz G; Perez KA; Nurjono M; Caragounis A; Du T; Laughton K; Volitakis I; Bush AI; Li QX; Masters CL; Cappai R; Cherny RA; Donnelly PS; White AR; Barnham KJ. 2009. Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation. Proc Natl Acad Sci U S A 106(2):381-6. [PubMed: 19122148]  [MGI Ref ID J:143873]

Cui W; Sun Y; Wang Z; Xu C; Peng Y; Li R. 2012. Liver X receptor activation attenuates inflammatory response and protects cholinergic neurons in APP/PS1 transgenic mice. Neuroscience 210:200-10. [PubMed: 22425753]  [MGI Ref ID J:184718]

D'Amico M; Di Filippo C; Marfella R; Abbatecola AM; Ferraraccio F; Rossi F; Paolisso G. 2010. Long-term inhibition of dipeptidyl peptidase-4 in Alzheimer's prone mice. Exp Gerontol 45(3):202-7. [PubMed: 20005285]  [MGI Ref ID J:158446]

Ding Y; Qiao A; Wang Z; Goodwin JS; Lee ES; Block ML; Allsbrook M; McDonald MP; Fan GH. 2008. Retinoic acid attenuates beta-amyloid deposition and rescues memory deficits in an Alzheimer's disease transgenic mouse model. J Neurosci 28(45):11622-34. [PubMed: 18987198]  [MGI Ref ID J:143199]

Donmez G; Wang D; Cohen DE; Guarente L. 2010. SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10. Cell 142(2):320-32. [PubMed: 20655472]  [MGI Ref ID J:163978]

Du J; Sun B; Chen K; Fan L; Wang Z. 2009. Antagonist of peroxisome proliferator-activated receptor gamma induces cerebellar amyloid-beta levels and motor dysfunction in APP/PS1 transgenic mice. Biochem Biophys Res Commun 384(3):357-61. [PubMed: 19422805]  [MGI Ref ID J:150592]

Du J; Sun B; Chen K; Zhang L; Liu S; Gu Q; Fan L; Zhao N; Wang Z. 2009. Metabolites of cerebellar neurons and hippocampal neurons play opposite roles in pathogenesis of Alzheimer's disease. PLoS ONE 4(5):e5530. [PubMed: 19436731]  [MGI Ref ID J:148883]

Duffy AM; Holscher C. 2013. The incretin analogue D-Ala(2)GIP reduces plaque load, astrogliosis and oxidative stress in an APP/PS1 mouse model of Alzheimer's disease. Neuroscience 228:294-300. [PubMed: 23103794]  [MGI Ref ID J:194003]

Duran-Aniotz C; Morales R; Moreno-Gonzalez I; Hu PP; Fedynyshyn J; Soto C. 2014. Aggregate-depleted brain fails to induce Abeta deposition in a mouse model of Alzheimer's disease. PLoS One 9(2):e89014. [PubMed: 24533166]  [MGI Ref ID J:212939]

Fan LF; Xu DE; Wang WH; Yan K; Wu H; Yao XQ; Xu RX; Liu CF; Ma QH. 2013. Caspr interaction with Amyloid Precursor Protein reduces amyloid-beta generation in vitro. Neurosci Lett 548:255-60. [PubMed: 23748076]  [MGI Ref ID J:201534]

Ferguson SA; Sarkar S; Schmued LC. 2013. Longitudinal behavioral changes in the APP/PS1 transgenic Alzheimer's disease model. Behav Brain Res 242:125-34. [PubMed: 23295401]  [MGI Ref ID J:197158]

Fisher Y; Strominger I; Biton S; Nemirovsky A; Baron R; Monsonego A. 2014. Th1 polarization of T cells injected into the cerebrospinal fluid induces brain immunosurveillance. J Immunol 192(1):92-102. [PubMed: 24307730]  [MGI Ref ID J:207169]

Fitz NF; Cronican AA; Saleem M; Fauq AH; Chapman R; Lefterov I; Koldamova R. 2012. Abca1 Deficiency Affects Alzheimer's Disease-Like Phenotype in Human ApoE4 But Not in ApoE3-Targeted Replacement Mice. J Neurosci 32(38):13125-36. [PubMed: 22993429]  [MGI Ref ID J:188282]

Frost JL; Le KX; Cynis H; Ekpo E; Kleinschmidt M; Palmour RM; Ervin FR; Snigdha S; Cotman CW; Saido TC; Vassar RJ; George-Hyslop PS; Ikezu T; Schilling S; Demuth HU; Lemere CA. 2013. Pyroglutamate-3 Amyloid-beta Deposition in the Brains of Humans, Non-Human Primates, Canines, and Alzheimer Disease-Like Transgenic Mouse Models. Am J Pathol 183(2):369-81. [PubMed: 23747948]  [MGI Ref ID J:199082]

Fu AK; Hung KW; Huang H; Gu S; Shen Y; Cheng EY; Ip FC; Huang X; Fu WY; Ip NY. 2014. Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer's disease. Proc Natl Acad Sci U S A 111(27):9959-64. [PubMed: 24958880]  [MGI Ref ID J:212169]

Garcia-Alloza M; Borrelli LA; Hyman BT; Bacskai BJ. 2010. Antioxidants have a rapid and long-lasting effect on neuritic abnormalities in APP:PS1 mice. Neurobiol Aging 31(12):2058-68. [PubMed: 19124175]  [MGI Ref ID J:168295]

Garcia-Alloza M; Borrelli LA; Rozkalne A; Hyman BT; Bacskai BJ. 2007. Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model J Neurochem 102(4):1095-104. [PubMed: 17472706]  [MGI Ref ID J:120785]

Garcia-Alloza M; Robbins EM; Zhang-Nunes SX; Prucell SM; Betensky RA; Raju S; Prada C; Greenberg SM; Bacskai BJ; Frosch MP. 2006. Charaterization of amyloid deposition in the APPswe/PS2dE9 mouse model of Alzheimer disease Neurobiol Dis 24(3):516-524. [PubMed: 17029828]  [MGI Ref ID J:113200]

Gimbel DA; Nygaard HB; Coffey EE; Gunther EC; Lauren J; Gimbel ZA; Strittmatter SM. 2010. Memory impairment in transgenic Alzheimer mice requires cellular prion protein. J Neurosci 30(18):6367-74. [PubMed: 20445063]  [MGI Ref ID J:160557]

Goto Y; Niidome T; Hongo H; Akaike A; Kihara T; Sugimoto H. 2008. Impaired muscarinic regulation of excitatory synaptic transmission in the APPswe/PS1dE9 mouse model of Alzheimer's disease. Eur J Pharmacol 583(1):84-91. [PubMed: 18282567]  [MGI Ref ID J:134791]

Griciuc A; Serrano-Pozo A; Parrado AR; Lesinski AN; Asselin CN; Mullin K; Hooli B; Choi SH; Hyman BT; Tanzi RE. 2013. Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta. Neuron 78(4):631-43. [PubMed: 23623698]  [MGI Ref ID J:201561]

Guo C; Wang T; Zheng W; Shan ZY; Teng WP; Wang ZY. 2013. Intranasal deferoxamine reverses iron-induced memory deficits and inhibits amyloidogenic APP processing in a transgenic mouse model of Alzheimer's disease. Neurobiol Aging 34(2):562-75. [PubMed: 22717236]  [MGI Ref ID J:194436]

Guo W; Sha S; Xing X; Jiang T; Cao Y. 2013. Reduction of cerebral Abeta burden and improvement in cognitive function in Tg-APPswe/PSEN1dE9 mice following vaccination with a multivalent Abeta3-10 DNA vaccine. Neurosci Lett 549:109-15. [PubMed: 23800542]  [MGI Ref ID J:201687]

Gurevicius K; Lipponen A; Tanila H. 2013. Increased cortical and thalamic excitability in freely moving APPswe/PS1dE9 mice modeling epileptic activity associated with Alzheimer's disease. Cereb Cortex 23(5):1148-58. [PubMed: 22581851]  [MGI Ref ID J:210154]

Halford RW; Russell DW. 2009. Reduction of cholesterol synthesis in the mouse brain does not affect amyloid formation in Alzheimer's disease, but does extend lifespan. Proc Natl Acad Sci U S A 106(9):3502-6. [PubMed: 19204288]  [MGI Ref ID J:146447]

Hamilton A; Holscher C. 2012. The effect of ageing on neurogenesis and oxidative stress in the APP(swe)/PS1(deltaE9) mouse model of Alzheimer's disease. Brain Res 1449:83-93. [PubMed: 22418058]  [MGI Ref ID J:183242]

Hazra A; Gu F; Aulakh A; Berridge C; Eriksen JL; Ziburkus J. 2013. Inhibitory neuron and hippocampal circuit dysfunction in an aged mouse model of Alzheimer's disease. PLoS One 8(5):e64318. [PubMed: 23691195]  [MGI Ref ID J:202168]

He G; Luo W; Li P; Remmers C; Netzer WJ; Hendrick J; Bettayeb K; Flajolet M; Gorelick F; Wennogle LP; Greengard P. 2010. Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease. Nature 467(7311):95-8. [PubMed: 20811458]  [MGI Ref ID J:163997]

Heneka MT; Kummer MP; Stutz A; Delekate A; Schwartz S; Vieira-Saecker A; Griep A; Axt D; Remus A; Tzeng TC; Gelpi E; Halle A; Korte M; Latz E; Golenbock DT. 2013. NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature 493(7434):674-8. [PubMed: 23254930]  [MGI Ref ID J:194405]

Heneka MT; Nadrigny F; Regen T; Martinez-Hernandez A; Dumitrescu-Ozimek L; Terwel D; Jardanhazi-Kurutz D; Walter J; Kirchhoff F; Hanisch UK; Kummer MP. 2010. Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine. Proc Natl Acad Sci U S A 107(13):6058-63. [PubMed: 20231476]  [MGI Ref ID J:158919]

Hickman SE; Allison EK; El Khoury J. 2008. Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice. J Neurosci 28(33):8354-60. [PubMed: 18701698]  [MGI Ref ID J:138606]

Hirsch-Reinshagen V; Chan JY; Wilkinson A; Tanaka T; Fan J; Ou G; Maia LF; Singaraja RR; Hayden MR; Wellington CL. 2007. Physiologically regulated transgenic ABCA1 does not reduce amyloid burden or amyloid-beta peptide levels in vivo. J Lipid Res 48(4):914-23. [PubMed: 17235115]  [MGI Ref ID J:121674]

Hirsch-Reinshagen V; Maia LF; Burgess BL; Blain JF; Naus KE; McIsaac SA; Parkinson PF; Chan JY; Tansley GH; Hayden MR; Poirier J; Van Nostrand W; Wellington CL. 2005. The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease. J Biol Chem 280(52):43243-56. [PubMed: 16207707]  [MGI Ref ID J:105900]

Ho A; Liu X; Sudhof TC. 2008. Deletion of Mint proteins decreases amyloid production in transgenic mouse models of Alzheimer's disease. J Neurosci 28(53):14392-400. [PubMed: 19118172]  [MGI Ref ID J:142874]

Hong X; Liu J; Zhu G; Zhuang Y; Suo H; Wang P; Huang D; Xu J; Huang Y; Yu M; Bian M; Sheng Z; Fei J; Song H; Behnisch T; Huang F. 2014. Parkin overexpression ameliorates hippocampal long-term potentiation and beta-amyloid load in an Alzheimer's disease mouse model. Hum Mol Genet 23(4):1056-72. [PubMed: 24105468]  [MGI Ref ID J:205991]

Hooijmans CR; Graven C; Dederen PJ; Tanila H; van Groen T; Kiliaan AJ. 2007. Amyloid beta deposition is related to decreased glucose transporter-1 levels and hippocampal atrophy in brains of aged APP/PS1 mice. Brain Res 1181:93-103. [PubMed: 17916337]  [MGI Ref ID J:127348]

Hooijmans CR; Rutters F; Dederen PJ; Gambarota G; Veltien A; van Groen T; Broersen LM; Lutjohann D; Heerschap A; Tanila H; Kiliaan AJ. 2007. Changes in cerebral blood volume and amyloid pathology in aged Alzheimer APP/PS1 mice on a docosahexaenoic acid (DHA) diet or cholesterol enriched Typical Western Diet (TWD). Neurobiol Dis 28(1):16-29. [PubMed: 17720508]  [MGI Ref ID J:134833]

Hoshino A; Helwig M; Rezaei S; Berridge C; Eriksen JL; Lindberg I. 2014. A novel function for proSAAS as an amyloid anti-aggregant in Alzheimer's disease. J Neurochem 128(3):419-30. [PubMed: 24102330]  [MGI Ref ID J:206615]

Hsiao YH; Kuo JR; Chen SH; Gean PW. 2012. Amelioration of social isolation-triggered onset of early Alzheimer's disease-related cognitive deficit by N-acetylcysteine in a transgenic mouse model. Neurobiol Dis 45(3):1111-20. [PubMed: 22227002]  [MGI Ref ID J:182319]

Hu YS; Long N; Pigino G; Brady ST; Lazarov O. 2013. Molecular mechanisms of environmental enrichment: impairments in Akt/GSK3beta, neurotrophin-3 and CREB signaling. PLoS One 8(5):e64460. [PubMed: 23700479]  [MGI Ref ID J:202121]

Israeli E; Yakunin E; Zarbiv Y; Hacohen-Solovich A; Kisos H; Loeb V; Lichtenstein M; Ben-Gedalya T; Sabag O; Pikarsky E; Lorberboum-Galski H; Sharon R. 2011. alpha-Synuclein Expression Selectively Affects Tumorigenesis in Mice Modeling Parkinson's Disease. PLoS One 6(5):e19622. [PubMed: 21611169]  [MGI Ref ID J:172735]

Jackson HM; Soto I; Graham LC; Carter GW; Howell GR. 2013. Clustering of transcriptional profiles identifies changes to insulin signaling as an early event in a mouse model of Alzheimer's disease. BMC Genomics 14:831. [PubMed: 24274089]  [MGI Ref ID J:208080]

Jankowsky JL; Younkin LH; Gonzales V; Fadale DJ; Slunt HH; Lester HA; Younkin SG; Borchelt DR. 2007. Rodent A beta modulates the solubility and distribution of amyloid deposits in transgenic mice. J Biol Chem 282(31):22707-20. [PubMed: 17556372]  [MGI Ref ID J:124804]

Jansen D; Zerbi V; Arnoldussen IA; Wiesmann M; Rijpma A; Fang XT; Dederen PJ; Mutsaers MP; Broersen LM; Lutjohann D; Miller M; Joosten LA; Heerschap A; Kiliaan AJ. 2013. Effects of specific multi-nutrient enriched diets on cerebral metabolism, cognition and neuropathology in AbetaPPswe-PS1dE9 mice. PLoS One 8(9):e75393. [PubMed: 24086523]  [MGI Ref ID J:206018]

Jansen D; Zerbi V; Janssen CI; Dederen PJ; Mutsaers MP; Hafkemeijer A; Janssen AL; Nobelen CL; Veltien A; Asten JJ; Heerschap A; Kiliaan AJ. 2013. A longitudinal study of cognition, proton MR spectroscopy and synaptic and neuronal pathology in aging wild-type and AbetaPPswe-PS1dE9 mice. PLoS One 8(5):e63643. [PubMed: 23717459]  [MGI Ref ID J:200837]

Jardanhazi-Kurutz D; Kummer MP; Terwel D; Vogel K; Thiele A; Heneka MT. 2011. Distinct adrenergic system changes and neuroinflammation in response to induced locus ceruleus degeneration in APP/PS1 transgenic mice. Neuroscience 176:396-407. [PubMed: 21129451]  [MGI Ref ID J:169872]

Jimenez-Palomares M; Ramos-Rodriguez JJ; Lopez-Acosta JF; Pacheco-Herrero M; Lechuga-Sancho AM; Perdomo G; Garcia-Alloza M; Cozar-Castellano I. 2012. Increased Abeta production prompts the onset of glucose intolerance and insulin resistance. Am J Physiol Endocrinol Metab 302(11):E1373-80. [PubMed: 22414803]  [MGI Ref ID J:186924]

Jin JJ; Kim HD; Maxwell JA; Li L; Fukuchi K. 2008. Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease. J Neuroinflammation 5:23. [PubMed: 18510752]  [MGI Ref ID J:174833]

Joshi G; Chi Y; Huang Z; Wang Y. 2014. Abeta-induced Golgi fragmentation in Alzheimer's disease enhances Abeta production. Proc Natl Acad Sci U S A 111(13):E1230-9. [PubMed: 24639524]  [MGI Ref ID J:207368]

Kagedal K; Kim WS; Appelqvist H; Chan S; Cheng D; Agholme L; Barnham K; McCann H; Halliday G; Garner B. 2010. Increased expression of the lysosomal cholesterol transporter NPC1 in Alzheimer's disease. Biochim Biophys Acta 1801(8):831-8. [PubMed: 20497909]  [MGI Ref ID J:165464]

Kamphuis W; Mamber C; Moeton M; Kooijman L; Sluijs JA; Jansen AH; Verveer M; de Groot LR; Smith VD; Rangarajan S; Rodriguez JJ; Orre M; Hol EM. 2012. GFAP isoforms in adult mouse brain with a focus on neurogenic astrocytes and reactive astrogliosis in mouse models of Alzheimer disease. PLoS One 7(8):e42823. [PubMed: 22912745]  [MGI Ref ID J:189978]

Kamphuis W; Orre M; Kooijman L; Dahmen M; Hol EM. 2012. Differential cell proliferation in the cortex of the APPswePS1dE9 Alzheimer's disease mouse model. Glia 60(4):615-29. [PubMed: 22262260]  [MGI Ref ID J:181304]

Kang JE; Lim MM; Bateman RJ; Lee JJ; Smyth LP; Cirrito JR; Fujiki N; Nishino S; Holtzman DM. 2009. Amyloid-{beta} Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle. Science :. [PubMed: 19779148]  [MGI Ref ID J:154074]

Kanninen K; Heikkinen R; Malm T; Rolova T; Kuhmonen S; Leinonen H; Yla-Herttuala S; Tanila H; Levonen AL; Koistinaho M; Koistinaho J. 2009. Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A 106(38):16505-10. [PubMed: 19805328]  [MGI Ref ID J:153226]

Kanninen K; Malm TM; Jyrkkanen HK; Goldsteins G; Keksa-Goldsteine V; Tanila H; Yamamoto M; Yla-Herttuala S; Levonen AL; Koistinaho J. 2008. Nuclear factor erythroid 2-related factor 2 protects against beta amyloid. Mol Cell Neurosci 39(3):302-13. [PubMed: 18706502]  [MGI Ref ID J:142109]

Kemppainen S; Rantamaki T; Jeronimo-Santos A; Lavasseur G; Autio H; Karpova N; Karkkainen E; Staven S; Miranda HV; Outeiro TF; Diogenes MJ; Laroche S; Davis S; Sebastiao AM; Castren E; Tanila H. 2012. Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice. Neurobiol Aging 33(6):1122.e23-39. [PubMed: 22209410]  [MGI Ref ID J:188313]

Kim J; Castellano JM; Jiang H; Basak JM; Parsadanian M; Pham V; Mason SM; Paul SM; Holtzman DM. 2009. Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance. Neuron 64(5):632-44. [PubMed: 20005821]  [MGI Ref ID J:155809]

Kim JY; Kim DH; Kim JH; Lee D; Jeon HB; Kwon SJ; Kim SM; Yoo YJ; Lee EH; Choi SJ; Seo SW; Lee JI; Na DL; Yang YS; Oh W; Chang JW. 2012. Soluble intracellular adhesion molecule-1 secreted by human umbilical cord blood-derived mesenchymal stem cell reduces amyloid-beta plaques. Cell Death Differ 19(4):680-91. [PubMed: 22015609]  [MGI Ref ID J:203613]

Kim MJ; Chae SS; Koh YH; Lee SK; Jo SA. 2010. Glutamate carboxypeptidase II: an amyloid peptide-degrading enzyme with physiological function in the brain. FASEB J 24(11):4491-502. [PubMed: 20624932]  [MGI Ref ID J:196634]

Kim T; Vidal GS; Djurisic M; William CM; Birnbaum ME; Garcia KC; Hyman BT; Shatz CJ. 2013. Human LilrB2 is a beta-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model. Science 341(6152):1399-404. [PubMed: 24052308]  [MGI Ref ID J:201126]

Knafo S; Venero C; Merino-Serrais P; Fernaud-Espinosa I; Gonzalez-Soriano J; Ferrer I; Santpere G; DeFelipe J. 2009. Morphological alterations to neurons of the amygdala and impaired fear conditioning in a transgenic mouse model of Alzheimer's disease. J Pathol 219(1):41-51. [PubMed: 19449368]  [MGI Ref ID J:151904]

Ko CY; Chang LH; Lee YC; Sterneck E; Cheng CP; Chen SH; Huang AM; Tseng JT; Wang JM. 2012. CCAAT/enhancer binding protein delta (CEBPD) elevating PTX3 expression inhibits macrophage-mediated phagocytosis of dying neuron cells. Neurobiol Aging 33(2):422.e11-25. [PubMed: 21112127]  [MGI Ref ID J:188222]

Ko CY; Wang WL; Wang SM; Chu YY; Chang WC; Wang JM. 2014. Glycogen synthase kinase-3beta-mediated CCAAT/enhancer-binding protein delta phosphorylation in astrocytes promotes migration and activation of microglia/macrophages. Neurobiol Aging 35(1):24-34. [PubMed: 23993701]  [MGI Ref ID J:211975]

Koffie RM ; Meyer-Luehmann M ; Hashimoto T ; Adams KW ; Mielke ML ; Garcia-Alloza M ; Micheva KD ; Smith SJ ; Kim ML ; Lee VM ; Hyman BT ; Spires-Jones TL. 2009. Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques. Proc Natl Acad Sci U S A 106(10):4012-7. [PubMed: 19228947]  [MGI Ref ID J:146596]

Koronyo-Hamaoui M; Ko MK; Koronyo Y; Azoulay D; Seksenyan A; Kunis G; Pham M; Bakhsheshian J; Rogeri P; Black KL; Farkas DL; Schwartz M. 2009. Attenuation of AD-like neuropathology by harnessing peripheral immune cells: local elevation of IL-10 and MMP-9. J Neurochem 111(6):1409-24. [PubMed: 19780903]  [MGI Ref ID J:156031]

Kuchibhotla KV; Lattarulo CR; Hyman BT; Bacskai BJ. 2009. Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice. Science 323(5918):1211-5. [PubMed: 19251629]  [MGI Ref ID J:145934]

Kumar S; Rezaei-Ghaleh N; Terwel D; Thal DR; Richard M; Hoch M; Mc Donald JM; Wullner U; Glebov K; Heneka MT; Walsh DM; Zweckstetter M; Walter J. 2011. Extracellular phosphorylation of the amyloid beta-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease. EMBO J 30(11):2255-65. [PubMed: 21527912]  [MGI Ref ID J:173179]

Kummer MP; Hammerschmidt T; Martinez A; Terwel D; Eichele G; Witten A; Figura S; Stoll M; Schwartz S; Pape HC; Schultze JL; Weinshenker D; Heneka MT. 2014. Ear2 deletion causes early memory and learning deficits in APP/PS1 mice. J Neurosci 34(26):8845-54. [PubMed: 24966384]  [MGI Ref ID J:212542]

Kummer MP; Hermes M; Delekarte A; Hammerschmidt T; Kumar S; Terwel D; Walter J; Pape HC; Konig S; Roeber S; Jessen F; Klockgether T; Korte M; Heneka MT. 2011. Nitration of tyrosine 10 critically enhances amyloid beta aggregation and plaque formation. Neuron 71(5):833-44. [PubMed: 21903077]  [MGI Ref ID J:176667]

Kummer MP; Vogl T; Axt D; Griep A; Vieira-Saecker A; Jessen F; Gelpi E; Roth J; Heneka MT. 2012. Mrp14 deficiency ameliorates amyloid beta burden by increasing microglial phagocytosis and modulation of amyloid precursor protein processing. J Neurosci 32(49):17824-9. [PubMed: 23223301]  [MGI Ref ID J:193190]

Kuszczyk MA; Sanchez S; Pankiewicz J; Kim J; Duszczyk M; Guridi M; Asuni AA; Sullivan PM; Holtzman DM; Sadowski MJ. 2013. Blocking the Interaction between Apolipoprotein E and Abeta Reduces Intraneuronal Accumulation of Abeta and Inhibits Synaptic Degeneration. Am J Pathol 182(5):1750-68. [PubMed: 23499462]  [MGI Ref ID J:195341]

Lalonde R; Kim HD; Fukuchi K. 2004. Exploratory activity, anxiety, and motor coordination in bigenic APPswe + PS1/DeltaE9 mice. Neurosci Lett 369(2):156-61. [PubMed: 15450687]  [MGI Ref ID J:93096]

Lalonde R; Kim HD; Maxwell JA; Fukuchi K. 2005. Exploratory activity and spatial learning in 12-month-old APP(695)SWE/co+PS1/DeltaE9 mice with amyloid plaques. Neurosci Lett 390(2):87-92. [PubMed: 16169151]  [MGI Ref ID J:104569]

Lam V; Takechi R; Pallebage-Gamarallage MM; Galloway S; Mamo JC. 2011. Colocalisation of plasma derived apo B lipoproteins with cerebral proteoglycans in a transgenic-amyloid model of Alzheimer's disease. Neurosci Lett 492(3):160-4. [PubMed: 21310214]  [MGI Ref ID J:170853]

Lamoke F; Ripandelli G; Webster S; Montemari A; Maraschi A; Martin P; Marcus DM; Liou GI; Bartoli M. 2012. Loss of thioredoxin function in retinas of mice overexpressing amyloid beta. Free Radic Biol Med 53(3):577-88. [PubMed: 22564527]  [MGI Ref ID J:186185]

Laursen B; Mork A; Plath N; Kristiansen U; Bastlund JF. 2013. Cholinergic degeneration is associated with increased plaque deposition and cognitive impairment in APPswe/PS1dE9 mice. Behav Brain Res 240:146-52. [PubMed: 23178660]  [MGI Ref ID J:197071]

Lee JE; Han PL. 2013. An update of animal models of Alzheimer disease with a reevaluation of plaque depositions. Exp Neurobiol 22(2):84-95. [PubMed: 23833557]  [MGI Ref ID J:202532]

Lefterov I; Fitz NF; Cronican AA; Fogg A; Lefterov P; Kodali R; Wetzel R; Koldamova R. 2010. Apolipoprotein A-I deficiency increases cerebral amyloid angiopathy and cognitive deficits in APP/PS1DeltaE9 mice. J Biol Chem 285(47):36945-57. [PubMed: 20739292]  [MGI Ref ID J:166877]

Lewis TL; Cao D; Lu H; Mans RA; Su YR; Jungbauer L; Linton MF; Fazio S; LaDu MJ; Li L. 2010. Overexpression of human apolipoprotein A-I preserves cognitive function and attenuates neuroinflammation and cerebral amyloid angiopathy in a mouse model of Alzheimer disease. J Biol Chem 285(47):36958-68. [PubMed: 20847045]  [MGI Ref ID J:167024]

Li HQ; Chen C; Dou Y; Wu HJ; Liu YJ; Lou HF; Zhang JM; Li XM; Wang H; Duan S. 2013. P2Y4 receptor-mediated pinocytosis contributes to amyloid beta-induced self-uptake by microglia. Mol Cell Biol 33(21):4282-93. [PubMed: 24001770]  [MGI Ref ID J:205417]

Li T; Wen H; Brayton C; Laird FM; Ma G; Peng S; Placanica L; Wu TC; Crain BJ; Price DL; Eberhart CG; Wong PC. 2007. Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities. J Neurosci 27(40):10849-59. [PubMed: 17913918]  [MGI Ref ID J:125592]

Liang B; Duan BY; Zhou XP; Gong JX; Luo ZG. 2010. Calpain activation promotes BACE1 expression, amyloid precursor protein processing, and amyloid plaque formation in a transgenic mouse model of Alzheimer disease. J Biol Chem 285(36):27737-44. [PubMed: 20595388]  [MGI Ref ID J:166179]

Liang X; Wang Q; Hand T; Wu L; Breyer RM; Montine TJ; Andreasson K. 2005. Deletion of the prostaglandin E2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer's disease. J Neurosci 25(44):10180-7. [PubMed: 16267225]  [MGI Ref ID J:102728]

Lim JE; Kou J; Song M; Pattanayak A; Jin J; Lalonde R; Fukuchi K. 2011. MyD88 deficiency ameliorates beta-amyloidosis in an animal model of Alzheimer's disease. Am J Pathol 179(3):1095-103. [PubMed: 21763676]  [MGI Ref ID J:176316]

Lim JE; Song M; Jin J; Kou J; Pattanayak A; Lalonde R; Fukuchi K. 2012. The effects of MyD88 deficiency on exploratory activity, anxiety, motor coordination, and spatial learning in C57BL/6 and APPswe/PS1dE9 mice. Behav Brain Res 227(1):36-42. [PubMed: 22051943]  [MGI Ref ID J:180681]

Liu HL; Zhao G; Zhang H; Shi LD. 2013. Long-term treadmill exercise inhibits the progression of Alzheimer's disease-like neuropathology in the hippocampus of APP/PS1 transgenic mice. Behav Brain Res 256:261-72. [PubMed: 23968591]  [MGI Ref ID J:202342]

Liu MY; Wang S; Yao WF; Zhang ZJ; Zhong X; Sha L; He M; Zheng ZH; Wei MJ. 2014. Memantine improves spatial learning and memory impairments by regulating NGF signaling in APP/PS1 transgenic mice. Neuroscience 273:141-51. [PubMed: 24846616]  [MGI Ref ID J:213211]

Liu R; Li JZ; Song JK; Zhou D; Huang C; Bai XY; Xie T; Zhang X; Li YJ; Wu CX; Zhang L; Li L; Zhang TT; Du GH. 2014. Pinocembrin improves cognition and protects the neurovascular unit in Alzheimer related deficits. Neurobiol Aging 35(6):1275-85. [PubMed: 24468471]  [MGI Ref ID J:213884]

Liu RM; van Groen T; Katre A; Cao D; Kadisha I; Ballinger C; Wang L; Carroll SL; Li L. 2011. Knockout of plasminogen activator inhibitor 1 gene reduces amyloid beta peptide burden in a mouse model of Alzheimer's disease. Neurobiol Aging 32(6):1079-89. [PubMed: 19604604]  [MGI Ref ID J:173735]

Liu S; Liu Y; Hao W; Wolf L; Kiliaan AJ; Penke B; Rube CE; Walter J; Heneka MT; Hartmann T; Menger MD; Fassbender K. 2012. TLR2 is a primary receptor for Alzheimer's amyloid beta peptide to trigger neuroinflammatory activation. J Immunol 188(3):1098-107. [PubMed: 22198949]  [MGI Ref ID J:180762]

Lok K; Zhao H; Shen H; Wang Z; Gao X; Zhao W; Yin M. 2013. Characterization of the APP/PS1 mouse model of Alzheimer's disease in senescence accelerated background. Neurosci Lett 557 Pt B:84-9. [PubMed: 24176881]  [MGI Ref ID J:207860]

Lourenco MV; Clarke JR; Frozza RL; Bomfim TR; Forny-Germano L; Batista AF; Sathler LB; Brito-Moreira J; Amaral OB; Silva CA; Freitas-Correa L; Espirito-Santo S; Campello-Costa P; Houzel JC; Klein WL; Holscher C; Carvalheira JB; Silva AM; Velloso LA; Munoz DP; Ferreira ST; De Felice FG. 2013. TNF-alpha mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's beta-amyloid oligomers in mice and monkeys. Cell Metab 18(6):831-43. [PubMed: 24315369]  [MGI Ref ID J:206139]

Ma T; Du X; Pick JE; Sui G; Brownlee M; Klann E. 2012. Glucagon-like peptide-1 cleavage product GLP-1(9-36) amide rescues synaptic plasticity and memory deficits in Alzheimer's disease model mice. J Neurosci 32(40):13701-8. [PubMed: 23035082]  [MGI Ref ID J:190933]

Ma T; Trinh MA; Wexler AJ; Bourbon C; Gatti E; Pierre P; Cavener DR; Klann E. 2013. Suppression of eIF2alpha kinases alleviates Alzheimer's disease-related plasticity and memory deficits. Nat Neurosci 16(9):1299-305. [PubMed: 23933749]  [MGI Ref ID J:203865]

Machova E; Jakubik J; Michal P; Oksman M; Iivonen H; Tanila H; Dolezal V. 2008. Impairment of muscarinic transmission in transgenic APPswe/PS1dE9 mice. Neurobiol Aging 29(3):368-78. [PubMed: 17140703]  [MGI Ref ID J:135055]

Machova E; Rudajev V; Smyckova H; Koivisto H; Tanila H; Dolezal V. 2010. Functional cholinergic damage develops with amyloid accumulation in young adult APPswe/PS1dE9 transgenic mice. Neurobiol Dis 38(1):27-35. [PubMed: 20053373]  [MGI Ref ID J:159939]

Malm TM; Iivonen H; Goldsteins G; Keksa-Goldsteine V; Ahtoniemi T; Kanninen K; Salminen A; Auriola S; Van Groen T; Tanila H; Koistinaho J. 2007. Pyrrolidine dithiocarbamate activates Akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden. J Neurosci 27(14):3712-21. [PubMed: 17409235]  [MGI Ref ID J:119404]

Matsuda S; Giliberto L; Matsuda Y; McGowan EM; D'Adamio L. 2008. BRI2 inhibits amyloid beta-peptide precursor protein processing by interfering with the docking of secretases to the substrate. J Neurosci 28(35):8668-76. [PubMed: 18753367]  [MGI Ref ID J:138796]

Matsumoto Y; Niimi N; Kohyama K. 2013. Development of a new DNA vaccine for Alzheimer disease targeting a wide range of abeta species and amyloidogenic peptides. PLoS One 8(9):e75203. [PubMed: 24086465]  [MGI Ref ID J:206020]

Mazzitelli S; Xu P; Ferrer I; Davis RJ; Tournier C. 2011. The Loss of c-Jun N-Terminal Protein Kinase Activity Prevents the Amyloidogenic Cleavage of Amyloid Precursor Protein and the Formation of Amyloid Plaques In Vivo. J Neurosci 31(47):16969-76. [PubMed: 22114267]  [MGI Ref ID J:178060]

McManus RM; Higgins SC; Mills KH; Lynch MA. 2014. Respiratory infection promotes T cell infiltration and amyloid-beta deposition in APP/PS1 mice. Neurobiol Aging 35(1):109-21. [PubMed: 23993702]  [MGI Ref ID J:211974]

Meckler X; Roseman J; Das P; Cheng H; Pei S; Keat M; Kassarjian B; Golde TE; Parent AT; Thinakaran G. 2010. Reduced Alzheimer's disease ss-amyloid deposition in transgenic mice expressing S-palmitoylation-deficient APH1aL and nicastrin. J Neurosci 30(48):16160-9. [PubMed: 21123562]  [MGI Ref ID J:166746]

Mei X; Ezan P; Giaume C; Koulakoff A. 2010. Astroglial connexin immunoreactivity is specifically altered at beta-amyloid plaques in beta-amyloid precursor protein/presenilin1 mice. Neuroscience 171(1):92-105. [PubMed: 20813165]  [MGI Ref ID J:169720]

Melnikova T; Savonenko A; Wang Q; Liang X; Hand T; Wu L; Kaufmann WE; Vehmas A; Andreasson KI. 2006. Cycloxygenase-2 activity promotes cognitive deficits but not increased amyloid burden in a model of Alzheimer's disease in a sex-dimorphic pattern. Neuroscience 141(3):1149-62. [PubMed: 16753269]  [MGI Ref ID J:111748]

Meyer-Luehmann M; Mielke M; Spires-Jones TL; Stoothoff W; Jones P; Bacskai BJ; Hyman BT. 2009. A reporter of local dendritic translocation shows plaque- related loss of neural system function in APP-transgenic mice. J Neurosci 29(40):12636-40. [PubMed: 19812338]  [MGI Ref ID J:153880]

Meyer-Luehmann M; Spires-Jones TL; Prada C; Garcia-Alloza M; de Calignon A; Rozkalne A; Koenigsknecht-Talboo J; Holtzman DM; Bacskai BJ; Hyman BT. 2008. Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease. Nature 451(7179):720-4. [PubMed: 18256671]  [MGI Ref ID J:132628]

Michaud JP; Bellavance MA; Prefontaine P; Rivest S. 2013. Real-time in vivo imaging reveals the ability of monocytes to clear vascular amyloid beta. Cell Rep 5(3):646-53. [PubMed: 24210819]  [MGI Ref ID J:205530]

Michaud JP; Halle M; Lampron A; Theriault P; Prefontaine P; Filali M; Tribout-Jover P; Lanteigne AM; Jodoin R; Cluff C; Brichard V; Palmantier R; Pilorget A; Larocque D; Rivest S. 2013. Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer's disease-related pathology. Proc Natl Acad Sci U S A 110(5):1941-6. [PubMed: 23322736]  [MGI Ref ID J:193688]

Minkeviciene R; Ihalainen J; Malm T; Matilainen O; Keksa-Goldsteine V; Goldsteins G; Iivonen H; Leguit N; Glennon J; Koistinaho J; Banerjee P; Tanila H. 2008. Age-related decrease in stimulated glutamate release and vesicular glutamate transporters in APP/PS1 transgenic and wild-type mice. J Neurochem 105(3):584-94. [PubMed: 18042177]  [MGI Ref ID J:134481]

Minkeviciene R; Rheims S; Dobszay MB; Zilberter M; Hartikainen J; Fulop L; Penke B; Zilberter Y; Harkany T; Pitkanen A; Tanila H. 2009. Amyloid beta-induced neuronal hyperexcitability triggers progressive epilepsy. J Neurosci 29(11):3453-62. [PubMed: 19295151]  [MGI Ref ID J:147045]

Minogue AM; Jones RS; Kelly RJ; McDonald CL; Connor TJ; Lynch MA. 2014. Age-associated dysregulation of microglial activation is coupled with enhanced blood-brain barrier permeability and pathology in APP/PS1 mice. Neurobiol Aging 35(6):1442-52. [PubMed: 24439957]  [MGI Ref ID J:213885]

Montgomery KS; Simmons RK; Edwards G 3rd; Nicolle MM; Gluck MA; Myers CE; Bizon JL. 2011. Novel age-dependent learning deficits in a mouse model of Alzheimer's disease: Implications for translational research. Neurobiol Aging 32(7):1273-85. [PubMed: 19720431]  [MGI Ref ID J:173732]

Mori T; Koyama N; Guillot-Sestier MV; Tan J; Town T. 2013. Ferulic acid is a nutraceutical beta-secretase modulator that improves behavioral impairment and alzheimer-like pathology in transgenic mice. PLoS One 8(2):e55774. [PubMed: 23409038]  [MGI Ref ID J:197205]

Mori T; Rezai-Zadeh K; Koyama N; Arendash GW; Yamaguchi H; Kakuda N; Horikoshi-Sakuraba Y; Tan J; Town T. 2012. Tannic acid is a natural beta-secretase inhibitor that prevents cognitive impairment and mitigates Alzheimer-like pathology in transgenic mice. J Biol Chem 287(9):6912-27. [PubMed: 22219198]  [MGI Ref ID J:182430]

Moskovitz J; Maiti P; Lopes DH; Oien DB; Attar A; Liu T; Mittal S; Hayes J; Bitan G. 2011. Induction of Methionine-Sulfoxide Reductases Protects Neurons from Amyloid beta-Protein Insults in Vitro and in Vivo. Biochemistry 50(49):10687-97. [PubMed: 22059533]  [MGI Ref ID J:178628]

Nabuurs RJ; Rutgers KS; Welling MM; Metaxas A; de Backer ME; Rotman M; Bacskai BJ; van Buchem MA; van der Maarel SM; van der Weerd L. 2012. In vivo detection of amyloid-beta deposits using heavy chain antibody fragments in a transgenic mouse model for Alzheimer's disease. PLoS One 7(6):e38284. [PubMed: 22675537]  [MGI Ref ID J:187847]

Ni Y; Zhao X; Bao G; Zou L; Teng L; Wang Z; Song M; Xiong J; Bai Y; Pei G. 2006. Activation of beta2-adrenergic receptor stimulates gamma-secretase activity and accelerates amyloid plaque formation. Nat Med 12(12):1390-6. [PubMed: 17115048]  [MGI Ref ID J:117739]

Ning A; Cui J; To E; Ashe KH; Matsubara J. 2008. Amyloid-beta deposits lead to retinal degeneration in a mouse model of Alzheimer disease. Invest Ophthalmol Vis Sci 49(11):5136-43. [PubMed: 18566467]  [MGI Ref ID J:141764]

O'Leary TP; Brown RE. 2009. Visuo-spatial learning and memory deficits on the Barnes maze in the 16-month-old APPswe/PS1dE9 mouse model of Alzheimer's disease. Behav Brain Res 201(1):120-7. [PubMed: 19428625]  [MGI Ref ID J:148386]

O'Neil JN; Mouton PR; Tizabi Y; Ottinger MA; Lei DL; Ingram DK; Manaye KF. 2007. Catecholaminergic neuronal loss in locus coeruleus of aged female dtg APP/PS1 mice. J Chem Neuroanat 34(3-4):102-7. [PubMed: 17658239]  [MGI Ref ID J:129903]

Oh ES; Savonenko AV; King JF; Fangmark Tucker SM; Rudow GL; Xu G; Borchelt DR; Troncoso JC. 2009. Amyloid precursor protein increases cortical neuron size in transgenic mice. Neurobiol Aging 30(8):1238-44. [PubMed: 18304698]  [MGI Ref ID J:152955]

Ohno M; Hiraoka Y; Lichtenthaler SF; Nishi K; Saijo S; Matsuoka T; Tomimoto H; Araki W; Takahashi R; Kita T; Kimura T; Nishi E. 2014. Nardilysin prevents amyloid plaque formation by enhancing alpha-secretase activity in an Alzheimer's disease mouse model. Neurobiol Aging 35(1):213-22. [PubMed: 23954170]  [MGI Ref ID J:211980]

Ordonez-Gutierrez L; Torres JM; Gavin R; Anton M; Arroba-Espinosa AI; Espinosa JC; Vergara C; Del Rio JA; Wandosell F. 2013. Cellular prion protein modulates beta-amyloid deposition in aged APP/PS1 transgenic mice. Neurobiol Aging 34(12):2793-804. [PubMed: 23831375]  [MGI Ref ID J:211720]

Ostapchenko VG; Beraldo FH; Guimaraes AL; Mishra S; Guzman M; Fan J; Martins VR; Prado VF; Prado MA. 2013. Increased prion protein processing and expression of metabotropic glutamate receptor 1 in a mouse model of Alzheimer's disease. J Neurochem 127(3):415-25. [PubMed: 23651058]  [MGI Ref ID J:202644]

Park JH; Gimbel DA; GrandPre T; Lee JK; Kim JE; Li W; Lee DH; Strittmatter SM. 2006. Alzheimer precursor protein interaction with the Nogo-66 receptor reduces amyloid-beta plaque deposition. J Neurosci 26(5):1386-95. [PubMed: 16452662]  [MGI Ref ID J:105196]

Park JH; Widi GA; Gimbel DA; Harel NY; Lee DH; Strittmatter SM. 2006. Subcutaneous Nogo receptor removes brain amyloid-beta and improves spatial memory in Alzheimer's transgenic mice. J Neurosci 26(51):13279-86. [PubMed: 17182778]  [MGI Ref ID J:116775]

Parthsarathy V; Holscher C. 2013. Chronic treatment with the GLP1 analogue liraglutide increases cell proliferation and differentiation into neurons in an AD mouse model. PLoS One 8(3):e58784. [PubMed: 23536825]  [MGI Ref ID J:200176]

Parthsarathy V; McClean PL; Holscher C; Taylor M; Tinker C; Jones G; Kolosov O; Salvati E; Gregori M; Masserini M; Allsop D. 2013. A novel retro-inverso peptide inhibitor reduces amyloid deposition, oxidation and inflammation and stimulates neurogenesis in the APPswe/PS1DeltaE9 mouse model of Alzheimer's disease. PLoS One 8(1):e54769. [PubMed: 23382963]  [MGI Ref ID J:195789]

Phillips M; Boman E; Osterman H; Willhite D; Laska M. 2011. Olfactory and visuospatial learning and memory performance in two strains of Alzheimer's disease model mice-a longitudinal study. PLoS One 6(5):e19567. [PubMed: 21573167]  [MGI Ref ID J:172426]

Pietropaolo S; Delage P; Lebreton F; Crusio WE; Cho YH. 2012. Early development of social deficits in APP and APP-PS1 mice. Neurobiol Aging 33(5):1002.e17-27. [PubMed: 22014620]  [MGI Ref ID J:188187]

Pihlaja R; Koistinaho J; Malm T; Sikkila H; Vainio S; Koistinaho M. 2008. Transplanted astrocytes internalize deposited beta-amyloid peptides in a transgenic mouse model of Alzheimer's disease. Glia 56(2):154-63. [PubMed: 18004725]  [MGI Ref ID J:156291]

Poirier R; Fernandez AM; Torres-Aleman I; Metzger F. 2012. Early brain amyloidosis in APP/PS1 mice with serum insulin-like growth factor-I deficiency. Neurosci Lett 509(2):101-4. [PubMed: 22230888]  [MGI Ref ID J:182316]

Ramos-Rodriguez JJ; Molina-Gil S; Rey-Brea R; Berrocoso E; Garcia-Alloza M. 2013. Specific serotonergic denervation affects tau pathology and cognition without altering senile plaques deposition in APP/PS1 mice. PLoS One 8(11):e79947. [PubMed: 24278223]  [MGI Ref ID J:209785]

Rantamaki T; Kemppainen S; Autio H; Staven S; Koivisto H; Kojima M; Antila H; Miettinen PO; Karkkainen E; Karpova N; Vesa L; Lindemann L; Hoener MC; Tanila H; Castren E. 2013. The impact of Bdnf gene deficiency to the memory impairment and brain pathology of APPswe/PS1dE9 mouse model of Alzheimer's disease. PLoS One 8(7):e68722. [PubMed: 23844236]  [MGI Ref ID J:204296]

Reed-Geaghan EG; Reed QW; Cramer PE; Landreth GE. 2010. Deletion of CD14 attenuates Alzheimer's disease pathology by influencing the brain's inflammatory milieu. J Neurosci 30(46):15369-73. [PubMed: 21084593]  [MGI Ref ID J:166445]

Rey NL; Jardanhazi-Kurutz D; Terwel D; Kummer MP; Jourdan F; Didier A; Heneka MT. 2012. Locus coeruleus degeneration exacerbates olfactory deficits in APP/PS1 transgenic mice. Neurobiol Aging 33(2):426.e1-11. [PubMed: 21109328]  [MGI Ref ID J:188223]

Richner M; Bach G; West MJ. 2009. Over expression of amyloid beta-protein reduces the number of neurons in the striatum of APPswe/PS1DeltaE9. Brain Res 1266:87-92. [PubMed: 19245800]  [MGI Ref ID J:145530]

Roh JH; Huang Y; Bero AW; Kasten T; Stewart FR; Bateman RJ; Holtzman DM. 2012. Disruption of the Sleep-Wake Cycle and Diurnal Fluctuation of beta-Amyloid in Mice with Alzheimer's Disease Pathology. Sci Transl Med 4(150):150ra122. [PubMed: 22956200]  [MGI Ref ID J:188120]

Rolova T; Puli L; Magga J; Dhungana H; Kanninen K; Wojciehowski S; Salminen A; Tanila H; Koistinaho J; Malm T. 2014. Complex regulation of acute and chronic neuroinflammatory responses in mouse models deficient for nuclear factor kappa B p50 subunit. Neurobiol Dis 64:16-29. [PubMed: 24345324]  [MGI Ref ID J:211484]

Rudinskiy N; Hawkes JM; Betensky RA; Eguchi M; Yamaguchi S; Spires-Jones TL; Hyman BT. 2012. Orchestrated experience-driven Arc responses are disrupted in a mouse model of Alzheimer's disease. Nat Neurosci 15(10):1422-9. [PubMed: 22922786]  [MGI Ref ID J:191574]

Saiz-Sanchez D; De La Rosa-Prieto C; Ubeda-Banon I; Martinez-Marcos A. 2013. Interneurons and Beta-Amyloid in the Olfactory Bulb, Anterior Olfactory Nucleus and Olfactory Tubercle in APPxPS1 Transgenic Mice Model of Alzheimer's Disease. Anat Rec (Hoboken) 296(9):1413-23. [PubMed: 23904197]  [MGI Ref ID J:199785]

Sashindranath M; Samson AL; Downes CE; Crack PJ; Lawrence AJ; Li QX; Ng AQ; Jones NC; Farrugia JJ; Abdella E; Vassalli JD; Madani R; Medcalf RL. 2011. Compartment- and context-specific changes in tissue-type plasminogen activator (tPA) activity following brain injury and pharmacological stimulation. Lab Invest 91(7):1079-91. [PubMed: 21519332]  [MGI Ref ID J:173193]

Scott L; Feng J; Kiss T; Needle E; Atchison K; Kawabe TT; Milici AJ; Hajos-Korcsok E; Riddell D; Hajos M. 2012. Age-dependent disruption in hippocampal theta oscillation in amyloid-beta overproducing transgenic mice. Neurobiol Aging 33(7):1481.e13-23. [PubMed: 22227005]  [MGI Ref ID J:188311]

Sehgal N; Gupta A; Valli RK; Joshi SD; Mills JT; Hamel E; Khanna P; Jain SC; Thakur SS; Ravindranath V. 2012. Withania somnifera reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver. Proc Natl Acad Sci U S A 109(9):3510-5. [PubMed: 22308347]  [MGI Ref ID J:182629]

Seo JS; Lee KW; Kim TK; Baek IS; Im JY; Han PL. 2011. Behavioral stress causes mitochondrial dysfunction via ABAD up-regulation and aggravates plaque pathology in the brain of a mouse model of Alzheimer disease. Free Radic Biol Med 50(11):1526-35. [PubMed: 21382475]  [MGI Ref ID J:172085]

Sepulveda-Falla D; Barrera-Ocampo A; Hagel C; Korwitz A; Vinueza-Veloz MF; Zhou K; Schonewille M; Zhou H; Velazquez-Perez L; Rodriguez-Labrada R; Villegas A; Ferrer I; Lopera F; Langer T; De Zeeuw CI; Glatzel M. 2014. Familial Alzheimer's disease-associated presenilin-1 alters cerebellar activity and calcium homeostasis. J Clin Invest 124(4):1552-67. [PubMed: 24569455]  [MGI Ref ID J:209633]

Shaftel SS; Kyrkanides S; Olschowka JA; Miller JN; Johnson RE; O'Banion MK. 2007. Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology. J Clin Invest 117(6):1595-604. [PubMed: 17549256]  [MGI Ref ID J:122022]

Shemer I; Holmgren C; Min R; Fulop L; Zilberter M; Sousa KM; Farkas T; Hartig W; Penke B; Burnashev N; Tanila H; Zilberter Y; Harkany T. 2006. Non-fibrillar beta-amyloid abates spike-timing-dependent synaptic potentiation at excitatory synapses in layer 2/3 of the neocortex by targeting postsynaptic AMPA receptors. Eur J Neurosci 23(8):2035-47. [PubMed: 16630051]  [MGI Ref ID J:108064]

Sheng JG; Price DL; Koliatsos VE. 2002. Disruption of corticocortical connections ameliorates amyloid burden in terminal fields in a transgenic model of Abeta amyloidosis. J Neurosci 22(22):9794-9. [PubMed: 12427835]  [MGI Ref ID J:134697]

Shi Q; Prior M; He W; Tang X; Hu X; Yan R. 2009. Reduced amyloid deposition in mice overexpressing RTN3 is adversely affected by preformed dystrophic neurites. J Neurosci 29(29):9163-73. [PubMed: 19625507]  [MGI Ref ID J:151798]

Sierksma AS; Prickaerts J; Chouliaras L; Rostamian S; Delbroek L; Rutten BP; Steinbusch HW; van den Hove DL. 2013. Behavioral and neurobiological effects of prenatal stress exposure in male and female APPswe/PS1dE9 mice. Neurobiol Aging 34(1):319-37. [PubMed: 22738723]  [MGI Ref ID J:191600]

Sierksma AS; Rutten K; Sydlik S; Rostamian S; Steinbusch HW; van den Hove DL; Prickaerts J. 2013. Chronic phosphodiesterase type 2 inhibition improves memory in the APPswe/PS1dE9 mouse model of Alzheimer's disease. Neuropharmacology 64:124-36. [PubMed: 22771768]  [MGI Ref ID J:192673]

Song S; Lee H; Kam TI; Tai ML; Lee JY; Noh JY; Shim SM; Seo SJ; Kong YY; Nakagawa T; Chung CW; Choi DY; Oubrahim H; Jung YK. 2008. E2-25K/Hip-2 regulates caspase-12 in ER stress-mediated Abeta neurotoxicity. J Cell Biol 182(4):675-84. [PubMed: 18710920]  [MGI Ref ID J:138978]

Sotthibundhu A; Li QX; Thangnipon W; Coulson EJ. 2009. Abeta(1-42) stimulates adult SVZ neurogenesis through the p75 neurotrophin receptor. Neurobiol Aging 30(12):1975-85. [PubMed: 18374455]  [MGI Ref ID J:155160]

Stoltenberg M; Bush AI; Bach G; Smidt K; Larsen A; Rungby J; Lund S; Doering P; Danscher G. 2007. Amyloid plaques arise from zinc-enriched cortical layers in APP/PS1 transgenic mice and are paradoxically enlarged with dietary zinc deficiency. Neuroscience 150(2):357-69. [PubMed: 17949919]  [MGI Ref ID J:130788]

Stover KR; Brown RE. 2012. Age-related changes in visual acuity, learning and memory in the APPswe/PS1dE9 mouse model of Alzheimer's disease. Behav Brain Res 231(1):75-85. [PubMed: 22409975]  [MGI Ref ID J:181681]

Stukas S; May S; Wilkinson A; Chan J; Donkin J; Wellington CL. 2012. The LXR agonist GW3965 increases apoA-I protein levels in the central nervous system independent of ABCA1. Biochim Biophys Acta 1821(3):536-46. [PubMed: 21889608]  [MGI Ref ID J:182371]

Su D; Zhao Y; Xu H; Wang B; Chen X; Chen J; Wang X. 2012. Isoflurane exposure during mid-adulthood attenuates age-related spatial memory impairment in APP/PS1 transgenic mice. PLoS One 7(11):e50172. [PubMed: 23185565]  [MGI Ref ID J:195580]

Sun S; Zhang H; Liu J; Popugaeva E; Xu NJ; Feske S; White CL 3rd; Bezprozvanny I. 2014. Reduced synaptic STIM2 expression and impaired store-operated calcium entry cause destabilization of mature spines in mutant presenilin mice. Neuron 82(1):79-93. [PubMed: 24698269]  [MGI Ref ID J:213159]

Sun X; Wu Y; Gu M; Zhang Y. 2014. miR-342-5p decreases ankyrin G levels in Alzheimer's disease transgenic mouse models. Cell Rep 6(2):264-70. [PubMed: 24440716]  [MGI Ref ID J:208793]

Takata K; Kitamura Y; Saeki M; Terada M; Kagitani S; Kitamura R; Fujikawa Y; Maelicke A; Tomimoto H; Taniguchi T; Shimohama S. 2010. Galantamine-induced amyloid-{beta} clearance mediated via stimulation of microglial nicotinic acetylcholine receptors. J Biol Chem 285(51):40180-91. [PubMed: 20947502]  [MGI Ref ID J:167587]

Takeda S; Hashimoto T; Roe AD; Hori Y; Spires-Jones TL; Hyman BT. 2013. Brain interstitial oligomeric amyloid beta increases with age and is resistant to clearance from brain in a mouse model of Alzheimer's disease. FASEB J 27(8):3239-48. [PubMed: 23640054]  [MGI Ref ID J:203564]

Tamayev R; Matsuda S; Giliberto L; Arancio O; D'Adamio L. 2011. APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutant. EMBO J 30(12):2501-9. [PubMed: 21587206]  [MGI Ref ID J:173362]

Taylor JM; Minter MR; Newman AG; Zhang M; Adlard PA; Crack PJ. 2014. Type-1 interferon signaling mediates neuro-inflammatory events in models of Alzheimer's disease. Neurobiol Aging 35(5):1012-23. [PubMed: 24262201]  [MGI Ref ID J:212738]

Thomas P; Wang YJ; Zhong JH; Kosaraju S; O'Callaghan NJ; Zhou XF; Fenech M. 2009. Grape seed polyphenols and curcumin reduce genomic instability events in a transgenic mouse model for Alzheimer's disease. Mutat Res 661(1-2):25-34. [PubMed: 19027755]  [MGI Ref ID J:145012]

Tian Y; Chang JC; Fan EY; Flajolet M; Greengard P. 2013. Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy. Proc Natl Acad Sci U S A 110(42):17071-6. [PubMed: 24067654]  [MGI Ref ID J:202011]

Town T; Laouar Y; Pittenger C; Mori T; Szekely CA; Tan J; Duman RS; Flavell RA. 2008. Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology. Nat Med 14(6):681-7. [PubMed: 18516051]  [MGI Ref ID J:137043]

Turdi S; Guo R; Huff AF; Wolf EM; Culver B; Ren J. 2009. Cardiomyocyte contractile dysfunction in the APPswe/PS1dE9 mouse model of Alzheimer's disease. PLoS One 4(6):e6033. [PubMed: 19551139]  [MGI Ref ID J:150191]

Um JW; Kaufman AC; Kostylev M; Heiss JK; Stagi M; Takahashi H; Kerrisk ME; Vortmeyer A; Wisniewski T; Koleske AJ; Gunther EC; Nygaard HB; Strittmatter SM. 2013. Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer abeta oligomer bound to cellular prion protein. Neuron 79(5):887-902. [PubMed: 24012003]  [MGI Ref ID J:201741]

Um JW; Nygaard HB; Heiss JK; Kostylev MA; Stagi M; Vortmeyer A; Wisniewski T; Gunther EC; Strittmatter SM. 2012. Alzheimer amyloid-beta oligomer bound to postsynaptic prion protein activates Fyn to impair neurons. Nat Neurosci 15(9):1227-35. [PubMed: 22820466]  [MGI Ref ID J:190064]

Volianskis A; Kostner R; Molgaard M; Hass S; Jensen MS. 2010. Episodic memory deficits are not related to altered glutamatergic synaptic transmission and plasticity in the CA1 hippocampus of the APPswe/PS1DeltaE9-deleted transgenic mice model of beta-amyloidosis. Neurobiol Aging 31(7):1173-87. [PubMed: 18790549]  [MGI Ref ID J:139071]

Vollert C; Forkuo GS; Bond RA; Eriksen JL. 2013. Chronic treatment with DCPCX, an adenosine A(1) antagonist, worsens long-term memory. Neurosci Lett 548:296-300. [PubMed: 23748072]  [MGI Ref ID J:201537]

Wang CY; Wang T; Zheng W; Zhao BL; Danscher G; Chen YH; Wang ZY. 2010. Zinc overload enhances APP cleavage and Abeta deposition in the Alzheimer mouse brain. PLoS One 5(12):e15349. [PubMed: 21179415]  [MGI Ref ID J:168997]

Wang H; Liu J; Zong Y; Xu Y; Deng W; Zhu H; Liu Y; Ma C; Huang L; Zhang L; Qin C. 2010. miR-106b aberrantly expressed in a double transgenic mouse model for Alzheimer's disease targets TGF-beta type II receptor. Brain Res 1357:166-74. [PubMed: 20709030]  [MGI Ref ID J:165149]

Wang J; Shan C; Cao W; Zhang C; Teng J; Chen J. 2013. SCG10 promotes non-amyloidogenic processing of amyloid precursor protein by facilitating its trafficking to the cell surface. Hum Mol Genet 22(24):4888-900. [PubMed: 23863461]  [MGI Ref ID J:203138]

Wang L; Chiang HC; Wu W; Liang B; Xie Z; Yao X; Ma W; Du S; Zhong Y. 2012. Epidermal growth factor receptor is a preferred target for treating amyloid-beta-induced memory loss. Proc Natl Acad Sci U S A 109(41):16743-8. [PubMed: 23019586]  [MGI Ref ID J:190314]

Wang Q; Xu Y; Chen JC; Qin YY; Liu M; Liu Y; Xie MJ; Yu ZY; Zhu Z; Wang W. 2012. Stromal cell-derived factor 1alpha decreases beta-amyloid deposition in Alzheimer's disease mouse model. Brain Res 1459:15-26. [PubMed: 22560596]  [MGI Ref ID J:186448]

Wang YJ; Wang X; Lu JJ; Li QX; Gao CY; Liu XH; Sun Y; Yang M; Lim Y; Evin G; Zhong JH; Masters C; Zhou XF. 2011. p75NTR regulates Abeta deposition by increasing Abeta production but inhibiting Abeta aggregation with its extracellular domain. J Neurosci 31(6):2292-304. [PubMed: 21307265]  [MGI Ref ID J:169451]

West MJ; Bach G; Soderman A; Jensen JL. 2009. Synaptic contact number and size in stratum radiatum CA1 of APP/PS1DeltaE9 transgenic mice. Neurobiol Aging 30(11):1756-76. [PubMed: 18336954]  [MGI Ref ID J:152954]

Wirz KT; Bossers K; Stargardt A; Kamphuis W; Swaab DF; Hol EM; Verhaagen J. 2013. Cortical beta amyloid protein triggers an immune response, but no synaptic changes in the APPswe/PS1dE9 Alzheimer's disease mouse model. Neurobiol Aging 34(5):1328-42. [PubMed: 23245294]  [MGI Ref ID J:203377]

Woodling NS; Wang Q; Priyam PG; Larkin P; Shi J; Johansson JU; Zagol-Ikapitte I; Boutaud O; Andreasson KI. 2014. Suppression of Alzheimer-associated inflammation by microglial prostaglandin-E2 EP4 receptor signaling. J Neurosci 34(17):5882-94. [PubMed: 24760848]  [MGI Ref ID J:210613]

Wu H; Williams J; Nathans J. 2014. Complete morphologies of basal forebrain cholinergic neurons in the mouse. Elife 3:e02444. [PubMed: 24894464]  [MGI Ref ID J:213265]

Xiao Q; Gil SC; Yan P; Wang Y; Han S; Gonzales E; Perez R; Cirrito JR; Lee JM. 2012. Role of phosphatidylinositol clathrin assembly lymphoid-myeloid leukemia (PICALM) in intracellular amyloid precursor protein (APP) processing and amyloid plaque pathogenesis. J Biol Chem 287(25):21279-89. [PubMed: 22539346]  [MGI Ref ID J:186509]

Xiao Z; Cilz NI; Kurada L; Hu B; Yang C; Wada E; Combs CK; Porter JE; Lesage F; Lei S. 2014. Activation of neurotensin receptor 1 facilitates neuronal excitability and spatial learning and memory in the entorhinal cortex: beneficial actions in an Alzheimer's disease model. J Neurosci 34(20):7027-42. [PubMed: 24828655]  [MGI Ref ID J:211262]

Xie H; Guan J; Borrelli LA; Xu J; Serrano-Pozo A; Bacskai BJ. 2013. Mitochondrial alterations near amyloid plaques in an Alzheimer's disease mouse model. J Neurosci 33(43):17042-51. [PubMed: 24155308]  [MGI Ref ID J:204673]

Xu G; Green CC; Fromholt SE; Borchelt DR. 2012. Reduction of low-density lipoprotein receptor-related protein (LRP1) in hippocampal neurons does not proportionately reduce, or otherwise alter, amyloid deposition in APPswe/PS1dE9 transgenic mice. Alzheimers Res Ther 4(2):12. [PubMed: 22537779]  [MGI Ref ID J:190171]

Xu G; Karch C; Li N; Lin N; Fromholt D; Gonzales V; Borchelt DR. 2008. Receptor-associated protein (RAP) plays a central role in modulating Abeta deposition in APP/PS1 transgenic mice. PLoS ONE 3(9):e3159. [PubMed: 18776935]  [MGI Ref ID J:143942]

Xu G; Stevens SM Jr; Moore BD; McClung S; Borchelt DR. 2013. Cytosolic proteins lose solubility as amyloid deposits in a transgenic mouse model of Alzheimer-type amyloidosis. Hum Mol Genet 22(14):2765-74. [PubMed: 23512986]  [MGI Ref ID J:198545]

Xu Z; Dong Y; Wang H; Culley DJ; Marcantonio ER; Crosby G; Tanzi RE; Zhang Y; Xie Z. 2014. Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice. Sci Rep 4:3766. [PubMed: 24441878]  [MGI Ref ID J:210096]

Yang GZ; Yang M; Lim Y; Lu JJ; Wang TH; Qi JG; Zhong JH; Zhou XF. 2012. Huntingtin associated protein 1 regulates trafficking of the amyloid precursor protein and modulates amyloid beta levels in neurons. J Neurochem 122(5):1010-22. [PubMed: 22731248]  [MGI Ref ID J:187639]

Yang H; Yang H; Xie Z; Wei L; Bi J. 2013. Systemic transplantation of human umbilical cord derived mesenchymal stem cells-educated T regulatory cells improved the impaired cognition in AbetaPPswe/PS1dE9 transgenic mice. PLoS One 8(7):e69129. [PubMed: 23935936]  [MGI Ref ID J:204355]

Yang SG; Wang SW; Zhao M; Zhang R; Zhou WW; Li YN; Su YJ; Zhang H; Yu XL; Liu RT. 2012. A peptide binding to the beta-site of APP improves spatial memory and attenuates Abeta burden in Alzheimer's disease transgenic mice. PLoS One 7(11):e48540. [PubMed: 23133641]  [MGI Ref ID J:195596]

Yoshiike Y; Kimura T; Yamashita S; Furudate H; Mizoroki T; Murayama M; Takashima A. 2008. GABA(A) receptor-mediated acceleration of aging-associated memory decline in APP/PS1 mice and its pharmacological treatment by picrotoxin. PLoS ONE 3(8):e3029. [PubMed: 18716656]  [MGI Ref ID J:139681]

Yun SM; Cho SJ; Song JC; Song SY; Jo SA; Jo C; Yoon K; Tanzi RE; Choi EJ; Koh YH. 2013. SUMO1 modulates Abeta generation via BACE1 accumulation. Neurobiol Aging 34(3):650-62. [PubMed: 22975420]  [MGI Ref ID J:194511]

Zamora E; Handisurya A; Shafti-Keramat S; Borchelt D; Rudow G; Conant K; Cox C; Troncoso JC; Kirnbauer R. 2006. Papillomavirus-like particles are an effective platform for amyloid-beta immunization in rabbits and transgenic mice. J Immunol 177(4):2662-70. [PubMed: 16888028]  [MGI Ref ID J:138349]

Zelcer N; Khanlou N; Clare R; Jiang Q; Reed-Geaghan EG; Landreth GE; Vinters HV; Tontonoz P. 2007. Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors. Proc Natl Acad Sci U S A 104(25):10601-6. [PubMed: 17563384]  [MGI Ref ID J:122372]

Zerbi V; Kleinnijenhuis M; Fang X; Jansen D; Veltien A; Van Asten J; Timmer N; Dederen PJ; Kiliaan AJ; Heerschap A. 2013. Gray and white matter degeneration revealed by diffusion in an Alzheimer mouse model. Neurobiol Aging 34(5):1440-50. [PubMed: 23273575]  [MGI Ref ID J:203373]

Zhang LH; Wang X; Zheng ZH; Ren H; Stoltenberg M; Danscher G; Huang L; Rong M; Wang ZY. 2010. Altered expression and distribution of zinc transporters in APP/PS1 transgenic mouse brain. Neurobiol Aging 31(1):74-87. [PubMed: 18378045]  [MGI Ref ID J:156810]

Zhang Q; Zhang X; Chen J; Miao Y; Sun A. 2009. Role of caspase-3 in tau truncation at D421 is restricted in transgenic mouse models for tauopathies. J Neurochem 109(2):476-84. [PubMed: 19200347]  [MGI Ref ID J:149265]

Zhang W; Bai M; Xi Y; Hao J; Liu L; Mao N; Su C; Miao J; Li Z. 2012. Early memory deficits precede plaque deposition in APPswe/PS1dE9 mice: Involvement of oxidative stress and cholinergic dysfunction. Free Radic Biol Med 52(8):1443-52. [PubMed: 22342520]  [MGI Ref ID J:182600]

Zhang W; Bai M; Xi Y; Hao J; Zhang Z; Su C; Lei G; Miao J; Li Z. 2012. Multiple inflammatory pathways are involved in the development and progression of cognitive deficits in APPswe/PS1dE9 mice. Neurobiol Aging 33(11):2661-77. [PubMed: 22277264]  [MGI Ref ID J:191173]

Zhang W; Hao J; Liu R; Zhang Z; Lei G; Su C; Miao J; Li Z. 2011. Soluble Abeta levels correlate with cognitive deficits in the 12-month-old APPswe/PS1dE9 mouse model of Alzheimer's disease. Behav Brain Res 222(2):342-50. [PubMed: 21513747]  [MGI Ref ID J:172201]

Zhang X; Luhrs KJ; Ryff KA; Malik WT; Driscoll MJ; Culver B. 2009. Suppression of nuclear factor kappa B ameliorates astrogliosis but not amyloid burden in APPswe/PS1dE9 mice. Neuroscience 161(1):53-8. [PubMed: 19286451]  [MGI Ref ID J:152589]

Zhang Y; Zhou B; Deng B; Zhang F; Wu J; Wang Y; Le Y; Zhai Q. 2013. Amyloid-beta induces hepatic insulin resistance in vivo via JAK2. Diabetes 62(4):1159-66. [PubMed: 23223021]  [MGI Ref ID J:208594]

Zhang Y; Zhou B; Zhang F; Wu J; Hu Y; Liu Y; Zhai Q. 2012. Amyloid-beta induces hepatic insulin resistance by activating JAK2/STAT3/SOCS-1 signaling pathway. Diabetes 61(6):1434-43. [PubMed: 22522613]  [MGI Ref ID J:196823]

Zhang Z; Goldschmidt T; Salter H. 2012. Possible allelic structure of IgG2a and IgG2c in mice. Mol Immunol 50(3):169-71. [PubMed: 22177661]  [MGI Ref ID J:181369]

Zhen G; Kim YT; Li RC; Yocum J; Kapoor N; Langer J; Dobrowolski P; Maruyama T; Narumiya S; Dore S. 2012. PGE2 EP1 receptor exacerbated neurotoxicity in a mouse model of cerebral ischemia and Alzheimer's disease. Neurobiol Aging 33(9):2215-9. [PubMed: 22015313]  [MGI Ref ID J:188185]

Zheng W; Xin N; Chi ZH; Zhao BL; Zhang J; Li JY; Wang ZY. 2009. Divalent metal transporter 1 is involved in amyloid precursor protein processing and Abeta generation. FASEB J 23(12):4207-17. [PubMed: 19679638]  [MGI Ref ID J:155170]

Zhou X; Hu X; He W; Tang X; Shi Q; Zhang Z; Yan R. 2011. Interaction between amyloid precursor protein and Nogo receptors regulates amyloid deposition. FASEB J 25(9):3146-56. [PubMed: 21670066]  [MGI Ref ID J:175718]

Zhu Y; Hou H; Rezai-Zadeh K; Giunta B; Ruscin A; Gemma C; Jin J; Dragicevic N; Bradshaw P; Rasool S; Glabe CG; Ehrhart J; Bickford P; Mori T; Obregon D; Town T; Tan J. 2011. CD45 Deficiency Drives Amyloid-{beta} Peptide Oligomers and Neuronal Loss in Alzheimer's Disease Mice. J Neurosci 31(4):1355-1365. [PubMed: 21273420]  [MGI Ref ID J:168546]

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Breeding & HusbandryWhen maintaining a live colony, hemizygotes may be bred with wildtype siblings. Coat color expected from breeding Black or Agouti. While the donating investigator warns that male aggression may require individual housing, there are no such reports of this problem to date in our colonies at The Jackson Laboratory (Jun 2006).
Mating System+/+ sibling x Hemizygote         (Female x Male)   28-OCT-13
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MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


(6.8)