Description

Strain Information

Former Names C3H/HeJ-snol/J    (Changed: 22-JUN-09 ) C3H/HeJ-snol    (Changed: 15-DEC-04 ) C3H/HeJ-snol/snol    (Changed: 15-DEC-04 ) Type Coisogenic; Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse H2 Haplotype k Generation F8+N8 (05-NOV-09) Generation Definitions

Appearance
agouti, snubnosed with malocclusion
Related Genotype: A/A snol/snol

agouti, unaffected
Related Genotype: A/A snol/+ or A/A +/?

Important Note
The C3H/HeJ background strain is homozygous for the retinal degeneration 1 mutation, Pde6b^rd1.

Description
The snol homozygous mutant phenotype includes a short nose, odd face and body shape, and kinked tail. Most mutants also get malocclusion and two homozygous mutants tested at 49 days of age exhibited intermediate hearing loss ( about 25 dB above normal). The odd shape of the face can be used to distinguish the Homozygotes by 14 days of age. snol has been mapped to Chromosome 4. The most likely gene order places the mutation between D4Mit12 and D4Mit203 in 92 tested meioses. A short nosed mutation, snubnose (sno), maps in this location, but could not be tested for allelism because it is believed to be extinct. The spina bifida occulta reported in sno homozygotes is not seen in snol homozygotes.

Development
The snubnose like mutation arose spontaneously in 1999 in the C3H/HeJ inbred strain at The Jackson Laboratory and has been maintained on this background.

Control Information

	Control
	Heterozygote from the colony
	Untyped from the colony
	000659 C3H/HeJ
Considerations for Choosing Controls

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI

      assigned by genotype

snol/snol

        C3H/HeJ

• mortality/aging
• partial preweaning lethality
  • incomplete penetrance; some mutant mice die by weaning age, although others may survive to adulthood and breed   (MGI Ref ID J:78986)
• craniofacial phenotype
• abnormal facial morphology
  • homozygous mutants are recognizable at about 14 days of postnatal development by their odd shaped face   (MGI Ref ID J:78986)
• • short snout
    • mice are described as having a short snout   (MGI Ref ID J:78986)
• malocclusion
  • most mutant mice get malocclusion   (MGI Ref ID J:78986)
• growth/size phenotype
• abnormal postnatal growth/weight/body size
  • mice are described as having an odd body shape   (MGI Ref ID J:78986)
• hearing/vestibular/ear phenotype
• decreased brainstem auditory evoked potential
  • ABR results showed that two homozygous mutant mice tested at 49 days of age exhibited intermediate hearing loss (about 25 dB above normal) and two +/? littermate control mice had normal hearing   (MGI Ref ID J:78986)
• limbs/digits/tail phenotype
• kinked tail   (MGI Ref ID J:78986)
• skeleton phenotype
• malocclusion
  • most mutant mice get malocclusion   (MGI Ref ID J:78986)

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

snol related

Developmental Biology Research
Craniofacial and Palate Defects
Skeletal Defects

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol		snol
Allele Name		snubnose-like
Allele Type		Spontaneous
Strain of Origin		C3H/HeJ
Gene Symbol and Name		snol, snubnose-like
Chromosome		4
General Note		A short nosed mutation, snubnose (sno), maps in this location, but could not be allele tested because it is believed to be extinct. The spina bifida occulta reported in sno is not seen in snol.
Molecular Note		A spontaneous mutation discovered at The Jackson Laboratory.

Genotyping

Genotyping Information

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Ward-Bailey PF; Harris B; Donahue LR; Bronson R; Curtain M; Johnson K; Davisson M. 2002. Snubnose-like (snol): a new spontaneous skeletal mutation on Chromosome 4 in the mouse. Mouse Mutant Resources Web Site, The Jackson Laboratory, Bar Harbor, Maine MGI Direct Data Submission :.  [MGI Ref ID J:78986]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           A1

Purchasing information

Pricing, Supply Level & Notes, Controls

General Supply Notes

• This strain is included in the Mouse Mutant Resource collection.
• Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

	Control
	Heterozygote from the colony
	Untyped from the colony
	000659 C3H/HeJ
Considerations for Choosing Controls
Control Pricing Information for Genetically Engineered Mutant Strains.

Important Note

The C3H/HeJ background strain is homozygous for the retinal degeneration 1 mutation, Pde6b^rd1.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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