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Strain Name:

NOD.NON-Thy1a/1LtJ

Stock Number:

004483

Availability:

Repository- Live

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General Terms and Conditions

Genes & Alleles   Thy1;   Thy1a;

Product Information

Strain Details

Type JAX® GEMM® Strain - Congenic
Additional information on JAX® GEMM® Strains.
Type JAX® GEMM® Strain - Mutant Strain
Mating SystemHomozygote x Homozygote         (Female x Male)
Specieslaboratory mouse
Background Strain NOD/ShiLt
Donor Strain NON/ShiLt
GenerationN21F41 (04-DEC-07)

Appearance
albino
Related Genotype: Tyrc/Tyrc

Strain Development
This strain was created in the laboratory of Dr. Edward Leiter, at The Jackson Laboratory, by continued backcrossing of the NON/HlLt-derived Thy1a allele from NOD.NON-Thy1a/J (N13; Stock Number 002721) onto the NOD/Lt background for an additional 8 generations, to N21. It has since been maintained by crossing siblings homozygous for Thy1a.

Gene & Allele Details

Allele Symbol Thy1a
Allele Name a variant
Common Name(s) Thy-1.1; Thy1.1; Thy1a;
Gene Symbol and Name Thy1, thymus cell antigen 1, theta
Chromosome 9
Gene Common Name(s) CD7; CD90; FLJ33325; T25; Thy 1.2; Thy-1; Thy-1.2; Thy1.1; Thy1.2;
General Note

The Thy1 locus determines an antigen present on cells of the thymus, a number of mouse leukemias, brain, and in lesser amounts on lymph node and spleen cells. The allele Thy1a determines an antigenic specificity, Thy-1.1, found in the AKR and RF strains; the allele Thy1b determines an antigenic specificity, Thy-1.2, found in the C3HeB/Fe and many other strains (J:5243, J:5012, J:4469). The Thy1 antigen is probably present on all T lymphocytes and absent from all B lymphocytes, and it thus serves as a valuable T-cell marker (J:5243). It is very widely used in experimentsdesigned to determine the distribution and function of T-cells. Thy1 specifies a T-cell surface glycoprotein, T25, with a molecular weight of 25 kDa (J:5707). The protein appears to be anchored in the cell membrane by a lipid that is either phosphotidylinositol or closely related to it (J:12016). Thy1 may function in the cell membrane as a signal transduction molecule (J:8333). The Thy1 locus, or possibly a gene closely linked to it, controls quantitative expression of a protein that is the same size as Thy1 and is expressed on thymus and brain but not on lymph node and spleen cells (J:7900).

Control Information

  Control
   001976 NOD/ShiLtJ
 
  Considerations for Choosing Controls

Colony Maintenance

Diet Information LabDiet® 5K52/5K67

Related Strains

View Strains carrying   Thy1a     (13 strains)

View Strains carrying other alleles of Thy1     (23 strains)

Additional Web Information

Congenic Nomenclature
Genetic Quality Control Annual Report
JAX Notes, Spring 1999; 477. Control Strains for NOD/LtJ Mice in Diabetes Research.

Animal Health Reports

Room Number           AX11

Research Applications

This mouse can be used to support research in many areas including:

Diabetes and Obesity Research
Islet Transplantation Studies
Type 1 Diabetes (IDDM) Analysis Strains (NOD/ShiLtJ Non-MHC Congenics)

Thy1a related

Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers

Research Tools
Genetics Research (Tissue/Cell Markers: T cell specific surface marker)
Immunology and Inflammation Research (T cell specific surface marker)

References

Selected Reference(s)

Christianson SW; Shultz LD; Leiter EH. 1993. Adoptive transfer of diabetes into immunodeficient NOD-scid/scid mice. Relative contributions of CD4+ and CD8+ T-cells from diabetic versus prediabetic NOD.NON-Thy-1a donors. Diabetes 42(1):44-55. [PubMed: 8093606]  [MGI Ref ID J:34990]

Fabien N; Bergerot I; Maguer-Satta V; Orgiazzi J; Thivolet C. 1995. Pancreatic lymph nodes are early targets of T cells during adoptive transfer of diabetes in NOD mice. J Autoimmun 8(3):323-34. [PubMed: 7575994]  [MGI Ref ID J:26213]

Additional References

Price and Supply Information

Strain Name: NOD.NON-Thy1a/1LtJ
Stock Number: 004483

Price Details

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Supply Details

Standard SupplyRepository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.
Supply Notes Usually shipped between four and eight weeks of age.
This strain is included in the Mouse Mutant Resource collection.
LicensingSee General Terms and Conditions below  
Control InformationView Control Information in Strain Details.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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