Strain Name: |
B6;AKR-Lxl2/J |
|---|---|
Stock Number: |
004502 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Genes & Alleles | Cdh23; Cdh23ahl; Lxl2; |
Product Information
Strain Details
Type JAX® GEMM® Strain - Mutant Stock Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Spontaneous Mutation Species laboratory mouse Generation N2F8N1p Appearance
black, affected
Related Genotype: a/a Lxl2/+
black, unaffected
Related Genotype: a/a +/+Important Note
Strain may be assorting Tyrc/+, so intercrossing may produce albino progeny. It may also be assorting Cdh23ahl/+, age related hearing loss 1.Strain Development
The Lxl2 mutation arose spontaneously in AKR/J at The Jackson Laboratory in 1998. Due to difficulty of maintenance on the AKR/J background Lxl2 was backcrossed twice to C57BL/6J and maintained on a segregating background. In 2003 embryos were produced for cryopreservation from C57BL/6J females and heterozygous males at generation N2F8.
Mammalian Phenotype Terms assigned by genotype |
Gene & Allele Details
| Allele Symbol | Lxl2 | ||
|---|---|---|---|
| Allele Name | luxate-like 2 | ||
| Strain of Origin | AKR/J | ||
| Molecular Note | Based on its phenotype and chromosomal location, Lxl2 is a probable remutation to Lx. Complementation tests were not performed because both mutations are dominant. | ||
| Allele Symbol | Cdh23ahl | ||
| Allele Name | age related hearing loss 1 | ||
| Common Name(s) | Cdh23753A; mdfw; | ||
Control Information
| Allele | Control | |
|---|---|---|
| Lxl2 | Wild-type littermate | |
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Cdh23ahl allele
001137 129P1/ReJ 000690 129P3/J 002065 129T2/SvEmsJ 000691 129X1/SvJ 000646 A/J 000647 A/WySnJ 003070 ALR/LtJ 003072 ALS/LtJ 001026 BALB/cByJ 000653 BUB/BnJ 005494 C3.129S1(B6)-Grm1rcw/J 000664 C57BL/6J 004764 C57BL/6J-Cdh23v-8J/J 003129 C57BL/6J-Epha4rb-2J/J 004820 C57BL/6J-Kcne12J/J 004703 C57BL/6J-Nmf134/J 004811 C57BL/6J-nmf110/J 004812 C57BL/6J-nmf111/J 004747 C57BL/6J-nmf118/J 004656 C57BL/6J-nmf88/J 004391 C57BL/6J-Chr 13A/J/NaJ 004385 C57BL/6J-Chr 7A/J/NaJ 000662 C57BLKS/J 000667 C57BR/cdJ 000668 C57L/J 000669 C58/J 000657 CE/J 000670 DBA/1J 001140 DBA/1LacJ 000671 DBA/2J 007048 DBA/2J-Gpnmb+/SjJ 002106 KK/HlJ 000675 LG/J 000676 LP/J 000677 MA/MyJ 001976 NOD/ShiLtJ 002050 NOR/LtJ 000679 P/J 002747 SENCARB/PtJ 002335 SKH2/J 003392 STOCK Crb1rd8/J View Strains carrying Cdh23ahl (41 strains)
002756 B6.CAST-Cdh23Ahl+/Kjn 002432 B6J x B6.C-H2bm1/ByJ-Cdh23v-J/J 002552 C57BL/6J-Cdh23v-2J/J 004764 C57BL/6J-Cdh23v-8J/J 004819 C57BL/6J-Cdh23v-9J/J 005016 CByJ;B6-Cdh23v-10J/J 000275 V/LeJ
Research Applications
This mouse can be used to support research in many areas including:Cdh23ahl related
Lxl2 relatedNeurobiology Research
Vestibular and Hearing Defects (Age related hearing loss)
Sensorineural Research
Vestibular and Hearing Defects (Age related hearing loss)
Developmental Biology Research
Skeletal Defects
References
Selected Reference(s)
Original article from The Mouse Mutant ResourceWard-Bailey PF; Harris BS; Donahue LR; Bronson RT; Johnson KR; Davisson MT. 2002. Luxate-like 2 (Lxl2), a remutation to luxate (Lx). Mouse Mutant Resources Web Site, The Jackson Laboratory, Bar Harbor, Maine (http://www.jax.org/mmr) MGI Direct Data Submission :. [J:79041]
Price and Supply Information
| Strain Name: | B6;AKR-Lxl2/J |
| Stock Number: | 004502 |
Price Details
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to the Supply Notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below |
| Control Information | View Control Information in Strain Details. |
General Terms and Conditions
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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