| |||||||||||||||||||
| Administration of diphtheria toxin (DT) depletes these mice of dendritic cell (DC) populations making them useful in studies of mononuclear phagocyte origins and the specific role of dendritic cells in the immune response. | |||||||||||||||||||
- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
- Health & care
- References
- Pricing & purchasing
- Terms of use
Description
Strain Information
Former Names B6.FVB-Tg(Itgax-DTR/GFP)57Drl (Changed: 15-DEC-04 ) B6.FVB-Tg(Itgax-DTR/GFP)57Lan/J (Changed: 15-DEC-04 ) B6.FVB-Tg(Itgax-DTR/GFP)57Litt (Changed: 15-DEC-04 ) CD11c-DTR (Changed: 15-DEC-04 ) Type Congenic; Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Inbred x Hemizygote (Female x Male) 01-MAR-06 Species laboratory mouse Generation N5+N17 (21-JUN-10)
Generation DefinitionsDonating Investigator Dr. Dan R. Littman, New York University Medical Center Description
Mice that are homozygous for the transgene are viable, normal in size and do not display any gross physical or behavioral abnormalities. Upon diphtheria toxin (DT) administration, mice harboring this transgene are transiently depleted of dendritic cell (DC) populations. All CD8+ and CD8- DC in the spleen express EGFP and are DT sensitive. Immunohistochemical and flow cytometric analysis reveals EGFP expression and DT-inducible depletion of CD11chigh DC in spleen, lymph node, lung, liver and lamina propria tissues, as well as the defined macrophage subpopulations of the alveolar, lamina propria, metallophillic and marginal zone. Rapid reduction of CD11c+ DC populations induced by intraperitoneal injection of DT persists for approximately 2 days, after which the cell population gradually recovers. While transient DC depletion was not associated with sign of illness or long-term defects, repeated DT induction is lethal to the mouse. Long term depletion of this cell population can be achieved by the generation of mixed irradiation chimeras.Development
A transgene was designed to place a simian Diphtheria Toxin Receptor (DTR)-Enhanced Green Fluorescent Protein (EGFP, Stratagene) fusion protein under the control of the Itgax (or CD11c) promoter. This transgene was introduced into fertilized FVB/N donor eggs. The resulting chimeric animals were crossed to C57BL/6 mice, and then backcrossed to C57BL/6 for 5 generations. This transgene has been mapped to mouse Chromosome 1 (~52 cM; 87395187bp position) via single nucleotide polymorphism (SNP) analysis by The Jackson Laboratory.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Fluorescent Protein Strains
View Fluorescent Protein Strains (357 strains)
004512 C.FVB-Tg(Itgax-DTR/EGFP)57Lan/J 008549 NOD.FVB-Tg(Itgax-DTR/EGFP)57Lan/JdkJ
008378 B6.Cg-Tg(Itgax-TGFBR2)1Flv/J 008829 B6.Cg-Tg(Itgax-Venus)1Mnz/J 008068 B6.Cg-Tg(Itgax-cre)1-1Reiz/J 008830 C.Cg-Tg(Itgax-Venus)1Mnz/J 007567 C57BL/6J-Tg(Itgax-cre,-EGFP)4097Ach/J 013233 NOD.B6-Tg(Itgax-cre,-EGFP)4097Ach/J 009422 NOD.Cg-Tg(Itgax-Venus)1Mnz/QtngJ
006000 B6.FVB-Tg(ITGAM-DTR/EGFP)34Lan/J 005515 FVB-Tg(ITGAM-DTR/EGFP)34Lan/J 008547 NOD.FVB-Tg(ITGAM-DTR/EGFP)34Lan/JdkJ
Additional Web Information
Fluorescent Proteins/lacZ Systems
JAX® NOTES, Fall 2002; 487. Green Fluorescent Protein (GFP) Transgenic Mice Poster Available.
Phenotype
Phenotype Information
assigned by genotype
Tg(Itgax-DTR/EGFP)57Lan/0
B6.FVB-Tg(Itgax-DTR/EGFP)57Lan/J
- mortality/aging
- increased sensitivity to induced morbidity/mortality
- mice exhibit an increase in mortality compared to wild-type mice following diphtheria treatment and cecal ligation puncture (CLP) (100% compared to 45% mortality) (MGI Ref ID J:113232)
- however, replacement of dendritic cells with wild-type dendritic cells improves survival (mortality drops from 100% to 65%) (MGI Ref ID J:113232)
- immune system phenotype
- *normal* immune system phenotype
- depletion of Cd11c+ dendritic cells by treatment with diphtheria toxin does not affect accumulation and localization of Tg(TcraTcrb)1100Mjb CD8+ T cells from a Rag1 null mouse in T cell zones of the lymph node and spleen (MGI Ref ID J:122114)
- conventional T cell, macrophages, B cell, NK cell, and NK T cell numbers are unaffected by treatment with diphtheria toxin (MGI Ref ID J:96123)
- despite an increase in mortality following diphtheria treatment and cecal ligation puncture, mice do not exhibit an increase in bacteremia or cytokine production (MGI Ref ID J:113232)
- abnormal NK T cell physiology
- following treatment with diphtheria toxin and stimulation with alpha-GalCer, 5% of spleen NK T cells stain positive for IFN-gamma and 8% for IL-4 compared to 32% and 30%, respectively, of similarly treated wild-type NK T cells (MGI Ref ID J:96123)
- however, normal levels of IFN-gamma and IL-4 production where observed in liver NK T cells (MGI Ref ID J:96123)
- abnormal NK cell physiology
- following treatment with diphtheria toxin and stimulation with alpha-GalCer, only 2% at 6 hours and 4% at 12 hours post-treatment of liver or spleen NK cells stain positive for IFN-gamma compared to 20% to 23% and 13% to 16%, respectively, of cells from transgenic mice not treated with diphtheria toxin (MGI Ref ID J:96123)
- following treatment with diphtheria toxin and stimulation with alpha-C-GalCer, less than 1% at 6 and 0.5% to 1% at 12 hours post-treatment of liver or spleen NK cells stain positive for IFN-gamma compared to 6% to 8% and 12% to 14%, respectively, of cells from transgenic mice not treated with diphtheria toxin (MGI Ref ID J:96123)
- impaired natural killer cell mediated cytotoxicity
- unlike in wild-type mice, NK T cell activation measured by specific cell lysis following infection with Leishmania infantum in diphtheria toxin treated mice does not occur (MGI Ref ID J:125611)
- decreased circulating interferon-gamma level
- following treatment with diphtheria toxin, little IFN-gamma in alpha-GalCer-injected mice and no IFN-gamma in alpha-C-GalCer-injected mice was detected unlike in transgenic mice not treated with diphtheria toxin (MGI Ref ID J:96123)
- decreased circulating interleukin-12 level
- following treatment with diphtheria toxin and stimulation with alpha-GalCer or alpha-C-GalCer, virtually no serum IL-12 was detected unlike in transgenic mice not treated with diphtheria toxin (MGI Ref ID J:96123)
- decreased dendritic cell number
- CD11c+ (Itgax+) dendritic cells in lung parenchyma are depleted following treatment with diphtheria toxin (MGI Ref ID J:100867)
- 24 hours after treatment with diphtheria toxin, spleens and livers are depleted of dendritic cells (MGI Ref ID J:96123)
- treatment with diphtheria toxin depletes CD11chighMHCIIhigh dendritic cells (MGI Ref ID J:113232)
- decreased interferon-gamma secretion
- following treatment with diphtheria toxin and stimulation with alpha-GalCer, only 2% at 6 hours and 4% at 12 hours post-treatment of liver or spleen NK cells stain positive for IFN-gamma compared to 20% to 23% and 13% to 16%, respectively, of cells from transgenic mice not treated with diphtheria toxin (MGI Ref ID J:96123)
- following treatment with diphtheria toxin and stimulation with alpha-GalCer, 5% of spleen NK T cells stain positive for IFN-gamma compared to 32% of similarly treated wild-type NK T cells (MGI Ref ID J:96123)
- however, normal levels of production where observed in liver NK T cells (MGI Ref ID J:96123)
- following treatment with diphtheria toxin and stimulation with alpha-C-GalCer, less than 1% at 6 and 0.5% to 1% at 12 hours post-treatment of liver or spleen NK cells stain positive for IFN-gamma compared to 6% to 8% and 12% to 14%, respectively, of cells from transgenic mice not treated with diphtheria toxin (MGI Ref ID J:96123)
- decreased interleukin-12b secretion
- unlike in wild-type mice, IL-12p40 production following infection with Leishmania infantum in diphtheria toxin treated mice does not occur (MGI Ref ID J:125611)
- decreased interleukin-4 secretion
- following treatment with diphtheria toxin and stimulation with alpha-GalCer, 8% of spleen NK T cells stain positive for IL-4 compared to 30% of similarly treated wild-type NK T cells however, normal levels of production where observed in liver NK T cells (MGI Ref ID J:96123)
- sepsis
- mice exhibit an increase in mortality compared to wild-type mice following diphtheria treatment and cecal ligation puncture (CLP) (100% compared to 45% mortality) (MGI Ref ID J:113232)
- homeostasis/metabolism phenotype
- decreased circulating interferon-gamma level
- following treatment with diphtheria toxin, little IFN-gamma in alpha-GalCer-injected mice and no IFN-gamma in alpha-C-GalCer-injected mice was detected unlike in transgenic mice not treated with diphtheria toxin (MGI Ref ID J:96123)
- decreased circulating interleukin-12 level
- following treatment with diphtheria toxin and stimulation with alpha-GalCer or alpha-C-GalCer, virtually no serum IL-12 was detected unlike in transgenic mice not treated with diphtheria toxin (MGI Ref ID J:96123)
- hematopoietic system phenotype
- decreased dendritic cell number
- CD11c+ (Itgax+) dendritic cells in lung parenchyma are depleted following treatment with diphtheria toxin (MGI Ref ID J:100867)
- 24 hours after treatment with diphtheria toxin, spleens and livers are depleted of dendritic cells (MGI Ref ID J:96123)
- treatment with diphtheria toxin depletes CD11chighMHCIIhigh dendritic cells (MGI Ref ID J:113232)
Tg(Itgax-DTR/EGFP)57Lan/0
B6.FVB-Tg(Itgax-DTR/EGFP)57Lan
- immune system phenotype
- abnormal circulating cytokine level
- after DT injection, an increase in Cxcl2 level is observed in serum, but not in Il1, 4, 5 or 7, Tnf, Ccl2, 3, or 5 levels (MGI Ref ID J:194800)
- altered susceptibility to infection
- at 30 hours after dendritic cell depletion in kidney by DT injection and infection with uropathogenic E. coli, numbers of polymorphonuclear neutrophils in kidneys are elevated and a 5-fold decrease in colony forming units of UPEC is observed compared to nondepleted control animals (MGI Ref ID J:194800)
- increased susceptibility to bacterial infection
- with diphtheria toxin at time of induction of pyelonephritis by transurethral infection by UPEC, animals show impaired bacterial clearance (MGI Ref ID J:194800)
- decreased dendritic cell number
- with injection of diphtheria toxin (DT) when transurethral instillation of uropathogenic E. coli (UPEC) is performed to produce a model of pyelonephritis, kidney dendritic cell numbers are reduced by 50% by 6 hours after DT treatment; 30 hours after DT-induced dendritic cell depletion, dendritic cell numbers are decreased by more than 90% in kidney (MGI Ref ID J:194800)
- the remaining dendritic cells are not functional, as they do not produce chemokines to attract polymorphonuclear neutrophils (MGI Ref ID J:194800)
- decreased neutrophil cell number
- at 24 hours after diphtheria toxin injection, numbers of PMNs are significantly decreased in bone marrow compared to controls (MGI Ref ID J:194800)
- impaired neutrophil recruitment
- with diphtheria toxin injection at time of induction of pyelonephritis by transurethral infection by UPEC, polymorphonuclear neutrophil (PMN) recruitment is decreased (MGI Ref ID J:194800)
- increased monocyte cell number
- blood monocyte numbers are 2-3 fold greater than control values at 72 hours after DT injection; intrarenal macrophage numbers are increased, peaking at 72 hours after DT (MGI Ref ID J:194800)
- increased neutrophil cell number
- 6 hours after diphtheria toxin injection to induce dendritic cell depletion in noninfected mice, slightly increased polymorphonuclear neutrophil (PMN) cell numbers are detected in the blood, with a 2-fold increase after 24 hours, and peaking at a 5-fold increase at 72 hours after DT treatment; higher intrarenal PMN numbers are seen at 24 and 72 hour (MGI Ref ID J:194800)
- hematopoietic system phenotype
- decreased dendritic cell number
- with injection of diphtheria toxin (DT) when transurethral instillation of uropathogenic E. coli (UPEC) is performed to produce a model of pyelonephritis, kidney dendritic cell numbers are reduced by 50% by 6 hours after DT treatment; 30 hours after DT-induced dendritic cell depletion, dendritic cell numbers are decreased by more than 90% in kidney (MGI Ref ID J:194800)
- the remaining dendritic cells are not functional, as they do not produce chemokines to attract polymorphonuclear neutrophils (MGI Ref ID J:194800)
- decreased neutrophil cell number
- at 24 hours after diphtheria toxin injection, numbers of PMNs are significantly decreased in bone marrow compared to controls (MGI Ref ID J:194800)
- increased monocyte cell number
- blood monocyte numbers are 2-3 fold greater than control values at 72 hours after DT injection; intrarenal macrophage numbers are increased, peaking at 72 hours after DT (MGI Ref ID J:194800)
- increased neutrophil cell number
- 6 hours after diphtheria toxin injection to induce dendritic cell depletion in noninfected mice, slightly increased polymorphonuclear neutrophil (PMN) cell numbers are detected in the blood, with a 2-fold increase after 24 hours, and peaking at a 5-fold increase at 72 hours after DT treatment; higher intrarenal PMN numbers are seen at 24 and 72 hour (MGI Ref ID J:194800)
- homeostasis/metabolism phenotype
- abnormal circulating cytokine level
- after DT injection, an increase in Cxcl2 level is observed in serum, but not in Il1, 4, 5 or 7, Tnf, Ccl2, 3, or 5 levels (MGI Ref ID J:194800)
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Tg(Itgax-DTR/EGFP)57Lan/0
C.FVB-Tg(Itgax-DTR/EGFP)57Lan
- mortality/aging
- premature death
- repeated treatment with diphtheria toxin results in lethality due to dendritic cell depletion (MGI Ref ID J:93488)
- immune system phenotype
- abnormal CD8-positive T cell differentiation
- adoptive transfer experiments demonstrate that CD8+ T cell priming with cell-associated antigen does not occur in diphtheria-induced dendritic cell depleted mice (MGI Ref ID J:93488)
- abnormal T cell activation
- treatment with diphtheria toxin results in a loss of in vitro stimulation of alloreactive T cells (MGI Ref ID J:93488)
- decreased CD8-positive T cell number
- treatment with diphtheria toxin results in a substantial loss of CD8+ T cells (MGI Ref ID J:93488)
- decreased dendritic cell number
- CD11c+ (Itgax+) dendritic cells are depleted for 2 days following treatment with diphtheria toxin (MGI Ref ID J:93488)
- defective cytotoxic T cell cytolysis
- in adoptive transfer experiments using diphtheria-induced dendritic cell depleted mice infected with Listeria or malaria at the liver stage (MGI Ref ID J:93488)
- increased neutrophil cell number
- neutrophilia is observed in blood after diphtheria toxin treatment, indicating that there is no background effect with respect to C57BL/6 (MGI Ref ID J:194800)
- hematopoietic system phenotype
- abnormal CD8-positive T cell differentiation
- adoptive transfer experiments demonstrate that CD8+ T cell priming with cell-associated antigen does not occur in diphtheria-induced dendritic cell depleted mice (MGI Ref ID J:93488)
- abnormal T cell activation
- treatment with diphtheria toxin results in a loss of in vitro stimulation of alloreactive T cells (MGI Ref ID J:93488)
- decreased CD8-positive T cell number
- treatment with diphtheria toxin results in a substantial loss of CD8+ T cells (MGI Ref ID J:93488)
- decreased dendritic cell number
- CD11c+ (Itgax+) dendritic cells are depleted for 2 days following treatment with diphtheria toxin (MGI Ref ID J:93488)
- increased neutrophil cell number
- neutrophilia is observed in blood after diphtheria toxin treatment, indicating that there is no background effect with respect to C57BL/6 (MGI Ref ID J:194800)
- cellular phenotype
- abnormal CD8-positive T cell differentiation
- adoptive transfer experiments demonstrate that CD8+ T cell priming with cell-associated antigen does not occur in diphtheria-induced dendritic cell depleted mice (MGI Ref ID J:93488)
- abnormal T cell activation
- treatment with diphtheria toxin results in a loss of in vitro stimulation of alloreactive T cells (MGI Ref ID J:93488)
Tg(Itgax-DTR/EGFP)57Lan/0
C.FVB-Tg(Itgax-DTR/EGFP)57Lan/J
- immune system phenotype
- *normal* immune system phenotype
- conventional T cell, macrophages, B cell, NK cell, and NK T cell numbers are unaffected by treatment with diphtheria toxin (MGI Ref ID J:96123)
- abnormal NK cell physiology
- following treatment with diphtheria toxin and stimulation with alpha-GalCer, only 2% at 6 hours and 4% at 12 hours post-treatment of liver or spleen NK cells stain positive for IFN-gamma compared to 20% to 23% and 13% to 16%, respectively, of cells from transgenic mice not treated with diphtheria toxin (MGI Ref ID J:96123)
- decreased circulating interferon-gamma level
- following treatment with diphtheria toxin, little IFN-gamma in alpha-GalCer-injected mice and no IFN-gamma in alpha-C-GalCer-injected mice was detected unlike in transgenic mice not treated with diphtheria toxin (MGI Ref ID J:96123)
- decreased circulating interleukin-12 level
- following treatment with diphtheria toxin and stimulation with alpha-GalCer or alpha-C-GalCer, virtually no serum IL-12 was detected unlike in transgenic mice not treated with diphtheria toxin (MGI Ref ID J:96123)
- decreased dendritic cell number
- 24 hours after treatment with diphtheria toxin, spleens and livers are depleted of dendritic cells (MGI Ref ID J:96123)
- decreased interferon-gamma secretion
- following treatment with diphtheria toxin and stimulation with alpha-GalCer, only 2% at 6 hours and 4% at 12 hours post-treatment of liver or spleen NK cells stain positive for IFN-gamma compared to 20% to 23% and 13% to 16%, respectively, of cells from transgenic mice not treated with diphtheria toxin (MGI Ref ID J:96123)
- homeostasis/metabolism phenotype
- decreased circulating interferon-gamma level
- following treatment with diphtheria toxin, little IFN-gamma in alpha-GalCer-injected mice and no IFN-gamma in alpha-C-GalCer-injected mice was detected unlike in transgenic mice not treated with diphtheria toxin (MGI Ref ID J:96123)
- decreased circulating interleukin-12 level
- following treatment with diphtheria toxin and stimulation with alpha-GalCer or alpha-C-GalCer, virtually no serum IL-12 was detected unlike in transgenic mice not treated with diphtheria toxin (MGI Ref ID J:96123)
- hematopoietic system phenotype
- decreased dendritic cell number
- 24 hours after treatment with diphtheria toxin, spleens and livers are depleted of dendritic cells (MGI Ref ID J:96123)
Tg(Itgax-DTR/EGFP)57Lan/0
involves: C57BL/6 * FVB/N
- immune system phenotype
- abnormal alveolar macrophage morphology
- CD11b+ Langerhans cells and alveolar macrophage are depleted following intratracheally administration of diphtheria toxin (MGI Ref ID J:137452)
- decreased dendritic cell number
- decreased interferon-gamma secretion
- following administration of diphtheria toxin and CD3 stimulation, IFN-gamma production by CD4 and CD8 T cells from the mesenteric lymph nodes is decreased compared to in similarly treated wild-type mice (MGI Ref ID J:137452)
- increased susceptibility to viral infection
- following intratracheally administration of diphtheria toxin, mice exhibit increased severity of influenza infection, increased weight lose and delayed clearance compared to infected wild-type mice (MGI Ref ID J:137452)
- the number of virus-specific cytotoxic T lymphoctes is reduced in mice treated with diphtheria toxin and infected with influenza compared to similarly treated wild-type mcie (MGI Ref ID J:137452)
- respiratory system phenotype
- abnormal alveolar macrophage morphology
- CD11b+ Langerhans cells and alveolar macrophage are depleted following intratracheally administration of diphtheria toxin (MGI Ref ID J:137452)
- hematopoietic system phenotype
- abnormal alveolar macrophage morphology
- CD11b+ Langerhans cells and alveolar macrophage are depleted following intratracheally administration of diphtheria toxin (MGI Ref ID J:137452)
- decreased dendritic cell number
This mouse can be used to support research in many areas including:
GFP relatedResearch Tools
Cancer Research
tumor immunology
xenograft/transplant host
Fluorescent Proteins
Immunology and Inflammation Research
Research Tools
Fluorescent Proteins
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Tg(Itgax-DTR/EGFP)57Lan | ||
|---|---|---|---|
| Allele Name | transgene insertion 57, Richard A Lang | ||
| Allele Type | Transgenic (random, expressed) | ||
| Common Name(s) | CD11c-DTR; CD11c-DTR/GFP; CD11c.DTR; CD11c/DTR Tg; CD11cDTR; CD11cDTR tg; DCKO; DTR-GFP; DTR-GRP; Itgax-DTR; Tg(Itgax-DTR/GFP)57Lan; Tg.Itgax-DTR/EGFP.57Lan; | ||
| Mutation Made By | Steffen Jung, Weizmann Institute of Science | ||
| Strain of Origin | FVB/N | ||
| Site of Expression | Expression of the transgene is specific to splenic dendritic cells. All CD8+ and CD8- dentritic cells in the spleen fluoresce and are DT sensititve. | ||
| Expressed Gene | DTR, Simian Diphtheria Toxin Receptor, | ||
| Expressed Gene | GFP, Green Fluorescent Protein, jellyfish | ||
| Green Fluorescent Protein (GFP), derived from the jellyfish Aequorea victoria, is a versatile reporter molecule which has found use in many biological applications. In some constructs the original molecule has been modified in order to enhance its fluorescence intensity (EGFP, enhanced GFP). When utilized in a transgenic construct, tissue expressing sufficient amounts of GFP will fluoresce when exposed to a 488 nm light source. | |||
| Promoter | Itgax, integrin alpha X, mouse, laboratory | ||
| Molecular Note | The transgene contains a fusion product involving simian diphtheria toxin receptor and green fluorescent protein under the control of the mouse Itgax promoter (CD11c). Two lines were created (line 11 and line 57) with 1 to 2 copies and 20 copies of the transgene, respectively. All CD8+ and CD8- dendritic cells in the spleen fluoresce and are DT sensitive. Immunohistochemical and flow cytometric analyses show that expression of the transgene is specific to splenic dendritic cells. [MGI Ref ID J:93488] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Fluorescent Proteins (Generic GFP), Melt Curve Analysis
Fluorescent Proteins (Generic GFP), Standard PCR
Fluorescent Proteins -- Generic GFP, QPCR
TG(DTR/EGFP), Standard PCR
Tg(ITGAM-DTR/EGFP), Melt Curve Analysis
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Jung S; Unutmaz D; Wong P; Sano G; De los Santos K; Sparwasser T; Wu S; Vuthoori S; Ko K; Zavala F; Pamer EG; Littman DR; Lang RA. 2002. In vivo depletion of CD11c(+) dendritic cells abrogates priming of CD8(+) T cells by exogenous cell-associated antigens. Immunity 17(2):211-20. [PubMed: 12196292] [MGI Ref ID J:93488]
Additional References
Tg(Itgax-DTR/EGFP)57Lan relatedAhmed KA; Wang L; Munegowda MA; Mulligan S; Gordon JR; Griebel P; Xiang J. 2012. Direct in vivo evidence of CD4+ T cell requirement for CTL response and memory via pMHC-I targeting and CD40L signaling. J Leukoc Biol 92(2):289-300. [PubMed: 22544940] [MGI Ref ID J:186191]
Bajwa A; Huang L; Ye H; Dondeti K; Song S; Rosin DL; Lynch KR; Lobo PI; Li L; Okusa MD. 2012. Dendritic cell sphingosine 1-phosphate receptor-3 regulates Th1-Th2 polarity in kidney ischemia-reperfusion injury. J Immunol 189(5):2584-96. [PubMed: 22855711] [MGI Ref ID J:189850]
Bamboat ZM; Ocuin LM; Balachandran VP; Obaid H; Plitas G; Dematteo RP. 2010. Conventional DCs reduce liver ischemia/reperfusion injury in mice via IL-10 secretion. J Clin Invest 120(2):559-69. [PubMed: 20093775] [MGI Ref ID J:156672]
Bar-On L; Birnberg T; Kim KW; Jung S. 2011. Dendritic cell-restricted CD80/86 deficiency results in peripheral regulatory T-cell reduction but is not associated with lymphocyte hyperactivation. Eur J Immunol 41(2):291-8. [PubMed: 21267999] [MGI Ref ID J:175433]
Bates JT; Graff AH; Phipps JP; Grayson JM; Mizel SB. 2011. Enhanced Antigen Processing of Flagellin Fusion Proteins Promotes the Antigen-Specific CD8+ T Cell Response Independently of TLR5 and MyD88. J Immunol 186(11):6255-62. [PubMed: 21515787] [MGI Ref ID J:173205]
Bates JT; Uematsu S; Akira S; Mizel SB. 2009. Direct stimulation of tlr5+/+ CD11c+ cells is necessary for the adjuvant activity of flagellin. J Immunol 182(12):7539-47. [PubMed: 19494277] [MGI Ref ID J:149297]
Behrens EM; Canna SW; Slade K; Rao S; Kreiger PA; Paessler M; Kambayashi T; Koretzky GA. 2011. Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice. J Clin Invest 121(6):2264-77. [PubMed: 21576823] [MGI Ref ID J:173903]
Bessa J; Jegerlehner A; Hinton HJ; Pumpens P; Saudan P; Schneider P; Bachmann MF. 2009. Alveolar macrophages and lung dendritic cells sense RNA and drive mucosal IgA responses. J Immunol 183(6):3788-99. [PubMed: 19710454] [MGI Ref ID J:152307]
Bianchi T; Pincus LB; Wurbel MA; Rich BE; Kupper TS; Fuhlbrigge RC; Boes M. 2009. Maintenance of peripheral tolerance through controlled tissue homing of antigen-specific T cells in K14-mOVA mice. J Immunol 182(8):4665-74. [PubMed: 19342642] [MGI Ref ID J:147741]
Birnberg T; Bar-On L; Sapoznikov A; Caton ML; Cervantes-Barragan L; Makia D; Krauthgamer R; Brenner O; Ludewig B; Brockschnieder D; Riethmacher D; Reizis B; Jung S. 2008. Lack of conventional dendritic cells is compatible with normal development and T cell homeostasis, but causes myeloid proliferative syndrome. Immunity 29(6):986-97. [PubMed: 19062318] [MGI Ref ID J:142682]
Bogunovic M; Ginhoux F; Helft J; Shang L; Hashimoto D; Greter M; Liu K; Jakubzick C; Ingersoll MA; Leboeuf M; Stanley ER; Nussenzweig M; Lira SA; Randolph GJ; Merad M. 2009. Origin of the lamina propria dendritic cell network. Immunity 31(3):513-25. [PubMed: 19733489] [MGI Ref ID J:152688]
Browne EP; Littman DR. 2009. Myd88 is required for an antibody response to retroviral infection. PLoS Pathog 5(2):e1000298. [PubMed: 19214214] [MGI Ref ID J:162196]
Butovsky O; Kunis G; Koronyo-Hamaoui M; Schwartz M. 2007. Selective ablation of bone marrow-derived dendritic cells increases amyloid plaques in a mouse Alzheimer's disease model. Eur J Neurosci 26(2):413-6. [PubMed: 17623022] [MGI Ref ID J:127277]
Campbell IK; van Nieuwenhuijze A; Segura E; O'Donnell K; Coghill E; Hommel M; Gerondakis S; Villadangos JA; Wicks IP. 2011. Differentiation of inflammatory dendritic cells is mediated by NF-kappaB1-dependent GM-CSF production in CD4 T cells. J Immunol 186(9):5468-77. [PubMed: 21421852] [MGI Ref ID J:172752]
Chappell CP; Draves KE; Giltiay NV; Clark EA. 2012. Extrafollicular B cell activation by marginal zone dendritic cells drives T cell-dependent antibody responses. J Exp Med 209(10):1825-40. [PubMed: 22966002] [MGI Ref ID J:191423]
Chiba S; Baghdadi M; Akiba H; Yoshiyama H; Kinoshita I; Dosaka-Akita H; Fujioka Y; Ohba Y; Gorman JV; Colgan JD; Hirashima M; Uede T; Takaoka A; Yagita H; Jinushi M. 2012. Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1. Nat Immunol 13(9):832-42. [PubMed: 22842346] [MGI Ref ID J:187594]
Choi DH; Kim KS; Yang SH; Chung DH; Song B; Sprent J; Cho JH; Sung YC. 2011. Dendritic Cell Internalization of alpha-Galactosylceramide from CD8 T Cells Induces Potent Antitumor CD8 T-cell Responses. Cancer Res 71(24):7442-51. [PubMed: 22028323] [MGI Ref ID J:178846]
Chyou S; Benahmed F; Chen J; Kumar V; Tian S; Lipp M; Lu TT. 2011. Coordinated regulation of lymph node vascular-stromal growth first by CD11c+ cells and then by T and B cells. J Immunol 187(11):5558-67. [PubMed: 22031764] [MGI Ref ID J:179758]
Ciavarra RP; Stephens A; Nagy S; Sekellick M; Steel C. 2006. Evaluation of immunological paradigms in a virus model: are dendritic cells critical for antiviral immunity and viral clearance? J Immunol 177(1):492-500. [PubMed: 16785546] [MGI Ref ID J:134380]
Darrasse-Jeze G; Deroubaix S; Mouquet H; Victora GD; Eisenreich T; Yao KH; Masilamani RF; Dustin ML; Rudensky A; Liu K; Nussenzweig MC. 2009. Feedback control of regulatory T cell homeostasis by dendritic cells in vivo. J Exp Med 206(9):1853-62. [PubMed: 19667061] [MGI Ref ID J:152171]
Denning TL; Wang YC; Patel SR; Williams IR; Pulendran B. 2007. Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses. Nat Immunol 8(10):1086-94. [PubMed: 17873879] [MGI Ref ID J:125258]
Desai DD; Harbers SO; Flores M; Colonna L; Downie MP; Bergtold A; Jung S; Clynes R. 2007. Fc gamma receptor IIB on dendritic cells enforces peripheral tolerance by inhibiting effector T cell responses. J Immunol 178(10):6217-26. [PubMed: 17475849] [MGI Ref ID J:146123]
Diao J; Zhao J; Winter E; Cattral MS. 2011. Tumors suppress in situ proliferation of cytotoxic T cells by promoting differentiation of Gr-1(+) conventional dendritic cells through IL-6. J Immunol 186(9):5058-67. [PubMed: 21430223] [MGI Ref ID J:172866]
Didierlaurent A; Goulding J; Patel S; Snelgrove R; Low L; Bebien M; Lawrence T; van Rijt LS; Lambrecht BN; Sirard JC; Hussell T. 2008. Sustained desensitization to bacterial Toll-like receptor ligands after resolution of respiratory influenza infection. J Exp Med 205(2):323-9. [PubMed: 18227219] [MGI Ref ID J:131869]
Divangahi M; Desjardins D; Nunes-Alves C; Remold HG; Behar SM. 2010. Eicosanoid pathways regulate adaptive immunity to Mycobacterium tuberculosis. Nat Immunol 11(8):751-8. [PubMed: 20622882] [MGI Ref ID J:162390]
Do JS; Min B. 2009. Differential requirements of MHC and of DCs for endogenous proliferation of different T-cell subsets in vivo. Proc Natl Acad Sci U S A 106(48):20394-8. [PubMed: 19920180] [MGI Ref ID J:155564]
Dolfi DV; Duttagupta PA; Boesteanu AC; Mueller YM; Oliai CH; Borowski AB; Katsikis PD. 2011. Dendritic cells and CD28 costimulation are required to sustain virus-specific CD8+ T cell responses during the effector phase in vivo. J Immunol 186(8):4599-608. [PubMed: 21389258] [MGI Ref ID J:172460]
Elhaik-Goldman S; Kafka D; Yossef R; Hadad U; Elkabets M; Vallon-Eberhard A; Hulihel L; Jung S; Ghadially H; Braiman A; Apte RN; Mandelboim O; Dagan R; Mizrachi-Nebenzahl Y; Porgador A. 2011. The Natural Cytotoxicity Receptor 1 Contribution to Early Clearance of Streptococcus pneumoniae and to Natural Killer-Macrophage Cross Talk. PLoS One 6(8):e23472. [PubMed: 21887255] [MGI Ref ID J:176154]
Engel D; Dobrindt U; Tittel A; Peters P; Maurer J; Gutgemann I; Kaissling B; Kuziel W; Jung S; Kurts C. 2006. Tumor necrosis factor alpha- and inducible nitric oxide synthase-producing dendritic cells are rapidly recruited to the bladder in urinary tract infection but are dispensable for bacterial clearance. Infect Immun 74(11):6100-7. [PubMed: 16966414] [MGI Ref ID J:113552]
Fei M; Bhatia S; Oriss TB; Yarlagadda M; Khare A; Akira S; Saijo S; Iwakura Y; Fallert Junecko BA; Reinhart TA; Foreman O; Ray P; Kolls J; Ray A. 2011. TNF-{alpha} from inflammatory dendritic cells (DCs) regulates lung IL-17A/IL-5 levels and neutrophilia versus eosinophilia during persistent fungal infection. Proc Natl Acad Sci U S A 108(13):5360-5. [PubMed: 21402950] [MGI Ref ID J:171233]
Ferrington DA; Roehrich H; Chang AA; Huang CW; Maldonado M; Bratten W; Rageh AA; Heuss ND; Gregerson DS; Nelson EF; Yuan C. 2013. Corneal wound healing is compromised by immunoproteasome deficiency. PLoS One 8(1):e54347. [PubMed: 23365662] [MGI Ref ID J:195798]
Frank GM; Buela KA; Maker DM; Harvey SA; Hendricks RL. 2012. Early responding dendritic cells direct the local NK response to control herpes simplex virus 1 infection within the cornea. J Immunol 188(3):1350-9. [PubMed: 22210909] [MGI Ref ID J:180749]
Fujii S; Goto A; Shimizu K. 2009. Antigen mRNA-transfected, allogeneic fibroblasts loaded with NKT-cell ligand confer antitumor immunity. Blood 113(18):4262-72. [PubMed: 19164596] [MGI Ref ID J:148431]
Fukuyama T; Kasper LH; Boussouar F; Jeevan T; van Deursen J; Brindle PK. 2009. Histone acetyltransferase CBP is vital to demarcate conventional and innate CD8+ T-cell development. Mol Cell Biol 29(14):3894-904. [PubMed: 19433445] [MGI Ref ID J:150146]
Gao N; Yin J; Yoon GS; Mi QS; Yu FS. 2011. Dendritic cell-epithelium interplay is a determinant factor for corneal epithelial wound repair. Am J Pathol 179(5):2243-53. [PubMed: 21924232] [MGI Ref ID J:177373]
Garaude J; Kent A; van Rooijen N; Blander JM. 2012. Simultaneous targeting of toll- and nod-like receptors induces effective tumor-specific immune responses. Sci Transl Med 4(120):120ra16. [PubMed: 22323829] [MGI Ref ID J:183811]
Garrod KR; Liu FC; Forrest LE; Parker I; Kang SM; Cahalan MD. 2010. NK cell patrolling and elimination of donor-derived dendritic cells favor indirect alloreactivity. J Immunol 184(5):2329-36. [PubMed: 20139277] [MGI Ref ID J:159639]
Gerard A; Khan O; Beemiller P; Oswald E; Hu J; Matloubian M; Krummel MF. 2013. Secondary T cell-T cell synaptic interactions drive the differentiation of protective CD8(+) T cells. Nat Immunol 14(4):356-63. [PubMed: 23475183] [MGI Ref ID J:194908]
Gereke M; Jung S; Buer J; Bruder D. 2009. Alveolar type II epithelial cells present antigen to CD4(+) T cells and induce Foxp3(+) regulatory T cells. Am J Respir Crit Care Med 179(5):344-55. [PubMed: 19096007] [MGI Ref ID J:165000]
GeurtsvanKessel CH; Willart MA; Bergen IM; van Rijt LS; Muskens F; Elewaut D; Osterhaus AD; Hendriks R; Rimmelzwaan GF; Lambrecht BN. 2009. Dendritic cells are crucial for maintenance of tertiary lymphoid structures in the lung of influenza virus-infected mice. J Exp Med 206(11):2339-49. [PubMed: 19808255] [MGI Ref ID J:154071]
GeurtsvanKessel CH; Willart MA; van Rijt LS; Muskens F; Kool M; Baas C; Thielemans K; Bennett C; Clausen BE; Hoogsteden HC; Osterhaus AD; Rimmelzwaan GF; Lambrecht BN. 2008. Clearance of influenza virus from the lung depends on migratory langerin+CD11b- but not plasmacytoid dendritic cells. J Exp Med 205(7):1621-34. [PubMed: 18591406] [MGI Ref ID J:137452]
Goold HD; Escors D; Conlan TJ; Chakraverty R; Bennett CL. 2011. Conventional dendritic cells are required for the activation of helper-dependent CD8 T cell responses to a model antigen after cutaneous vaccination with lentiviral vectors. J Immunol 186(8):4565-72. [PubMed: 21389256] [MGI Ref ID J:172461]
Guimond M; Freud AG; Mao HC; Yu J; Blaser BW; Leong JW; Vandeusen JB; Dorrance A; Zhang J; Mackall CL; Caligiuri MA. 2010. In vivo role of Flt3 ligand and dendritic cells in NK cell homeostasis. J Immunol 184(6):2769-75. [PubMed: 20142363] [MGI Ref ID J:160121]
Guimond M; Veenstra RG; Grindler DJ; Zhang H; Cui Y; Murphy RD; Kim SY; Na R; Hennighausen L; Kurtulus S; Erman B; Matzinger P; Merchant MS; Mackall CL. 2009. Interleukin 7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4+ T cells. Nat Immunol 10(2):149-57. [PubMed: 19136960] [MGI Ref ID J:144504]
Gupta A; Probst HC; Vuong V; Landshammer A; Muth S; Yagita H; Schwendener R; Pruschy M; Knuth A; van den Broek M. 2012. Radiotherapy promotes tumor-specific effector CD8+ T cells via dendritic cell activation. J Immunol 189(2):558-66. [PubMed: 22685313] [MGI Ref ID J:189554]
Hammad H; Plantinga M; Deswarte K; Pouliot P; Willart MA; Kool M; Muskens F; Lambrecht BN. 2010. Inflammatory dendritic cells--not basophils--are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen. J Exp Med 207(10):2097-111. [PubMed: 20819925] [MGI Ref ID J:165817]
Hapfelmeier S; Muller AJ; Stecher B; Kaiser P; Barthel M; Endt K; Eberhard M; Robbiani R; Jacobi CA; Heikenwalder M; Kirschning C; Jung S; Stallmach T; Kremer M; Hardt WD. 2008. Microbe sampling by mucosal dendritic cells is a discrete, MyD88-independent step in DeltainvG S. Typhimurium colitis. J Exp Med 205(2):437-50. [PubMed: 18268033] [MGI Ref ID J:132107]
Harbers SO; Crocker A; Catalano G; D'Agati V; Jung S; Desai DD; Clynes R. 2007. Antibody-enhanced cross-presentation of self antigen breaks T cell tolerance. J Clin Invest 117(5):1361-9. [PubMed: 17446931] [MGI Ref ID J:122114]
He LZ; Crocker A; Lee J; Mendoza-Ramirez J; Wang XT; Vitale LA; O'Neill T; Petromilli C; Zhang HF; Lopez J; Rohrer D; Keler T; Clynes R. 2007. Antigenic targeting of the human mannose receptor induces tumor immunity. J Immunol 178(10):6259-67. [PubMed: 17475854] [MGI Ref ID J:146119]
Hebel K; Griewank K; Inamine A; Chang HD; Muller-Hilke B; Fillatreau S; Manz RA; Radbruch A; Jung S. 2006. Plasma cell differentiation in T-independent type 2 immune responses is independent of CD11c(high) dendritic cells. Eur J Immunol 36(11):2912-9. [PubMed: 17051619] [MGI Ref ID J:117008]
Heuss ND; Lehmann U; Norbury CC; McPherson SW; Gregerson DS. 2012. Local activation of dendritic cells alters the pathogenesis of autoimmune disease in the retina. J Immunol 188(3):1191-200. [PubMed: 22219322] [MGI Ref ID J:180741]
Hickman HD; Li L; Reynoso GV; Rubin EJ; Skon CN; Mays JW; Gibbs J; Schwartz O; Bennink JR; Yewdell JW. 2011. Chemokines control naive CD8+ T cell selection of optimal lymph node antigen presenting cells. J Exp Med 208(12):2511-24. [PubMed: 22042976] [MGI Ref ID J:178641]
Hsieh SH; Lin JS; Huang JH; Wu SY; Chu CL; Kung JT; Wu-Hsieh BA. 2011. Immunization with apoptotic phagocytes containing Histoplasma capsulatum activates functional CD8(+) T cells to protect against histoplasmosis. Infect Immun 79(11):4493-502. [PubMed: 21911464] [MGI Ref ID J:177771]
Iijima N; Mattei LM; Iwasaki A. 2011. Recruited inflammatory monocytes stimulate antiviral Th1 immunity in infected tissue. Proc Natl Acad Sci U S A 108(1):284-9. [PubMed: 21173243] [MGI Ref ID J:169008]
Johnson S; Zhan Y; Sutherland RM; Mount AM; Bedoui S; Brady JL; Carrington EM; Brown LE; Belz GT; Heath WR; Lew AM. 2009. Selected Toll-like receptor ligands and viruses promote helper-independent cytotoxic T cell priming by upregulating CD40L on dendritic cells. Immunity 30(2):218-27. [PubMed: 19200758] [MGI Ref ID J:146462]
Joshi SK; Lang GA; Devera TS; Johnson AM; Kovats S; Lang ML. 2012. Differential contribution of dendritic cell CD1d to NKT cell-enhanced humoral immunity and CD8+ T cell activation. J Leukoc Biol 91(5):783-90. [PubMed: 22331103] [MGI Ref ID J:183803]
Kassim SH; Rajasagi NK; Zhao X; Chervenak R; Jennings SR. 2006. In vivo ablation of CD11c-positive dendritic cells increases susceptibility to herpes simplex virus type 1 infection and diminishes NK and T-cell responses. J Virol 80(8):3985-93. [PubMed: 16571815] [MGI Ref ID J:144132]
Katzman SD; O'Gorman WE; Villarino AV; Gallo E; Friedman RS; Krummel MF; Nolan GP; Abbas AK. 2010. Duration of antigen receptor signaling determines T-cell tolerance or activation. Proc Natl Acad Sci U S A 107(42):18085-90. [PubMed: 20921406] [MGI Ref ID J:165535]
Kim TS; Hufford MM; Sun J; Fu YX; Braciale TJ. 2010. Antigen persistence and the control of local T cell memory by migrant respiratory dendritic cells after acute virus infection. J Exp Med 207(6):1161-72. [PubMed: 20513748] [MGI Ref ID J:163416]
Kirby AC; Beattie L; Maroof A; van Rooijen N; Kaye PM. 2009. SIGNR1-negative red pulp macrophages protect against acute streptococcal sepsis after Leishmania donovani-induced loss of marginal zone macrophages. Am J Pathol 175(3):1107-15. [PubMed: 19644016] [MGI Ref ID J:152907]
Kono H; Karmarkar D; Iwakura Y; Rock KL. 2010. Identification of the cellular sensor that stimulates the inflammatory response to sterile cell death. J Immunol 184(8):4470-8. [PubMed: 20220089] [MGI Ref ID J:160055]
Kool M; Soullie T; van Nimwegen M; Willart MA; Muskens F; Jung S; Hoogsteden HC; Hammad H; Lambrecht BN. 2008. Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells. J Exp Med 205(4):869-82. [PubMed: 18362170] [MGI Ref ID J:133978]
Krebs DL; Chehal MK; Sio A; Huntington ND; Da ML; Ziltener P; Inglese M; Kountouri N; Priatel JJ; Jones J; Tarlinton DM; Anderson GP; Hibbs ML; Harder KW. 2012. Lyn-dependent signaling regulates the innate immune response by controlling dendritic cell activation of NK cells. J Immunol 188(10):5094-105. [PubMed: 22491248] [MGI Ref ID J:188683]
Kupz A; Guarda G; Gebhardt T; Sander LE; Short KR; Diavatopoulos DA; Wijburg OL; Cao H; Waithman JC; Chen W; Fernandez-Ruiz D; Whitney PG; Heath WR; Curtiss R 3rd; Tschopp J; Strugnell RA; Bedoui S. 2012. NLRC4 inflammasomes in dendritic cells regulate noncognate effector function by memory CD8 T cells. Nat Immunol 13(2):162-9. [PubMed: 22231517] [MGI Ref ID J:181212]
Kurche JS; Burchill MA; Sanchez PJ; Haluszczak C; Kedl RM. 2010. Comparison of OX40 Ligand and CD70 in the Promotion of CD4+ T Cell Responses. J Immunol 185(4):2106-15. [PubMed: 20639485] [MGI Ref ID J:162543]
Kuwajima S; Sato T; Ishida K; Tada H; Tezuka H; Ohteki T. 2006. Interleukin 15-dependent crosstalk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation. Nat Immunol 7(7):740-6. [PubMed: 16715101] [MGI Ref ID J:112665]
LaCasse CJ; Janikashvili N; Larmonier CB; Alizadeh D; Hanke N; Kartchner J; Situ E; Centuori S; Har-Noy M; Bonnotte B; Katsanis E; Larmonier N. 2011. Th-1 lymphocytes induce dendritic cell tumor killing activity by an IFN-gamma-dependent mechanism. J Immunol 187(12):6310-7. [PubMed: 22075702] [MGI Ref ID J:180408]
Lauterbach H; Bathke B; Gilles S; Traidl-Hoffmann C; Luber CA; Fejer G; Freudenberg MA; Davey GM; Vremec D; Kallies A; Wu L; Shortman K; Chaplin P; Suter M; O'Keeffe M; Hochrein H. 2010. Mouse CD8alpha+ DCs and human BDCA3+ DCs are major producers of IFN-lambda in response to poly IC. J Exp Med 207(12):2703-17. [PubMed: 20975040] [MGI Ref ID J:176879]
Lee PY; Weinstein JS; Nacionales DC; Scumpia PO; Li Y; Butfiloski E; van Rooijen N; Moldawer L; Satoh M; Reeves WH. 2008. A Novel Type I IFN-Producing Cell Subset in Murine Lupus. J Immunol 180(7):5101-8. [PubMed: 18354236] [MGI Ref ID J:133377]
Liu CH; Fan YT; Dias A; Esper L; Corn RA; Bafica A; Machado FS; Aliberti J. 2006. Cutting edge: dendritic cells are essential for in vivo IL-12 production and development of resistance against Toxoplasma gondii infection in mice. J Immunol 177(1):31-5. [PubMed: 16785494] [MGI Ref ID J:134413]
Liu Z; Noh HS; Chen J; Kim JH; Falo LD Jr; You Z. 2008. Potent tumor-specific protection ignited by adoptively transferred CD4+ T cells. J Immunol 181(6):4363-70. [PubMed: 18768895] [MGI Ref ID J:139077]
London A; Itskovich E; Benhar I; Kalchenko V; Mack M; Jung S; Schwartz M. 2011. Neuroprotection and progenitor cell renewal in the injured adult murine retina requires healing monocyte-derived macrophages. J Exp Med 208(1):23-39. [PubMed: 21220455] [MGI Ref ID J:176855]
Lu M; Munford RS. 2011. The transport and inactivation kinetics of bacterial lipopolysaccharide influence its immunological potency in vivo. J Immunol 187(6):3314-20. [PubMed: 21849675] [MGI Ref ID J:179236]
Lucas M; Schachterle W; Oberle K; Aichele P; Diefenbach A. 2007. Dendritic cells prime natural killer cells by trans-presenting interleukin 15. Immunity 26(4):503-17. [PubMed: 17398124] [MGI Ref ID J:123584]
Magalhaes JG; Rubino SJ; Travassos LH; Le Bourhis L; Duan W; Sellge G; Geddes K; Reardon C; Lechmann M; Carneiro LA; Selvanantham T; Fritz JH; Taylor BC; Artis D; Mak TW; Comeau MR; Croft M; Girardin SE; Philpott DJ. 2011. Nucleotide oligomerization domain-containing proteins instruct T cell helper type 2 immunity through stromal activation. Proc Natl Acad Sci U S A 108(36):14896-901. [PubMed: 21856952] [MGI Ref ID J:175223]
Mandaric S; Walton SM; Rulicke T; Richter K; Girard-Madoux MJ; Clausen BE; Zurunic A; Kamanaka M; Flavell RA; Jonjic S; Oxenius A. 2012. IL-10 suppression of NK/DC crosstalk leads to poor priming of MCMV-specific CD4 T cells and prolonged MCMV persistence. PLoS Pathog 8(8):e1002846. [PubMed: 22876184] [MGI Ref ID J:195373]
Markey KA; Banovic T; Kuns RD; Olver SD; Don AL; Raffelt NC; Wilson YA; Raggatt LJ; Pettit AR; Bromberg JS; Hill GR; MacDonald KP. 2009. Conventional dendritic cells are the critical donor APC presenting alloantigen after experimental bone marrow transplantation. Blood 113(22):5644-9. [PubMed: 19336758] [MGI Ref ID J:148895]
McAleer JP; Zammit DJ; Lefrancois L; Rossi RJ; Vella AT. 2007. The lipopolysaccharide adjuvant effect on T cells relies on nonoverlapping contributions from the MyD88 pathway and CD11c+ cells. J Immunol 179(10):6524-35. [PubMed: 17982041] [MGI Ref ID J:153867]
McCartney SA; Vermi W; Lonardi S; Rossini C; Otero K; Calderon B; Gilfillan S; Diamond MS; Unanue ER; Colonna M. 2011. RNA sensor-induced type I IFN prevents diabetes caused by a beta cell-tropic virus in mice. J Clin Invest 121(4):1497-507. [PubMed: 21403398] [MGI Ref ID J:172007]
McDonald KG; McDonough JS; Dieckgraefe BK; Newberry RD. 2010. Dendritic cells produce CXCL13 and participate in the development of murine small intestine lymphoid tissues. Am J Pathol 176(5):2367-77. [PubMed: 20304952] [MGI Ref ID J:160774]
Meredith MM; Liu K; Darrasse-Jeze G; Kamphorst AO; Schreiber HA; Guermonprez P; Idoyaga J; Cheong C; Yao KH; Niec RE; Nussenzweig MC. 2012. Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage. J Exp Med 209(6):1153-65. [PubMed: 22615130] [MGI Ref ID J:189122]
Milam JE; Erb-Downward JR; Chen GH; Osuchowski MF; McDonald R; Chensue SW; Toews GB; Huffnagle GB; Olszewski MA. 2010. CD11c+ cells are required to prevent progression from local acute lung injury to multiple organ failure and death. Am J Pathol 176(1):218-26. [PubMed: 19948830] [MGI Ref ID J:156379]
Miyake Y; Asano K; Kaise H; Uemura M; Nakayama M; Tanaka M. 2007. Critical role of macrophages in the marginal zone in the suppression of immune responses to apoptotic cell-associated antigens. J Clin Invest 117(8):2268-78. [PubMed: 17657313] [MGI Ref ID J:123958]
Mortier E; Woo T; Advincula R; Gozalo S; Ma A. 2008. IL-15Ralpha chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation. J Exp Med 205(5):1213-25. [PubMed: 18458113] [MGI Ref ID J:136221]
Mott KR; Gate D; Zandian M; Allen SJ; Rajasagi NK; van Rooijen N; Chen S; Arditi M; Rouse BT; Flavell RA; Town T; Ghiasi H. 2011. Macrophage IL-12p70 Signaling Prevents HSV-1-Induced CNS Autoimmunity Triggered by Autoaggressive CD4+ Tregs. Invest Ophthalmol Vis Sci 52(5):2321-33. [PubMed: 21220560] [MGI Ref ID J:171538]
Mott KR; Underhill D; Wechsler SL; Ghiasi H. 2008. Lymphoid-related CD11c+ CD8alpha+ dendritic cells are involved in enhancing herpes simplex virus type 1 latency. J Virol 82(20):9870-9. [PubMed: 18667491] [MGI Ref ID J:153404]
Mourao-Sa D; Robinson MJ; Zelenay S; Sancho D; Chakravarty P; Larsen R; Plantinga M; Van Rooijen N; Soares MP; Lambrecht B; Reis E Sousa C. 2011. CLEC-2 signaling via Syk in myeloid cells can regulate inflammatory responses. Eur J Immunol 41(10):3040-53. [PubMed: 21728173] [MGI Ref ID J:176982]
Moussion C; Girard JP. 2011. Dendritic cells control lymphocyte entry to lymph nodes through high endothelial venules. Nature 479(7374):542-6. [PubMed: 22080953] [MGI Ref ID J:178295]
Muniz LR; Pacer ME; Lira SA; Furtado GC. 2011. A critical role for dendritic cells in the formation of lymphatic vessels within tertiary lymphoid structures. J Immunol 187(2):828-34. [PubMed: 21666055] [MGI Ref ID J:178041]
Murillo O; Dubrot J; Palazon A; Arina A; Azpilikueta A; Alfaro C; Solano S; Ochoa MC; Berasain C; Gabari I; Perez-Gracia JL; Berraondo P; Hervas-Stubbs S; Melero I. 2009. In vivo depletion of DC impairs the anti-tumor effect of agonistic anti-CD137 mAb. Eur J Immunol 39(9):2424-36. [PubMed: 19662633] [MGI Ref ID J:152180]
Nakano H; Lin KL; Yanagita M; Charbonneau C; Cook DN; Kakiuchi T; Gunn MD. 2009. Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses. Nat Immunol 10(4):394-402. [PubMed: 19252492] [MGI Ref ID J:148008]
O'Connor RA; Leech MD; Suffner J; Hammerling GJ; Anderton SM. 2010. Myelin-reactive, TGF-beta-induced regulatory T cells can be programmed to develop Th1-like effector function but remain less proinflammatory than myelin-reactive Th1 effectors and can suppress pathogenic T cell clonal expansion in vivo. J Immunol 185(12):7235-43. [PubMed: 21084662] [MGI Ref ID J:167459]
Obeid M; Tesniere A; Ghiringhelli F; Fimia GM; Apetoh L; Perfettini JL; Castedo M; Mignot G; Panaretakis T; Casares N; Metivier D; Larochette N; van Endert P; Ciccosanti F; Piacentini M; Zitvogel L; Kroemer G. 2007. Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat Med 13(1):54-61. [PubMed: 17187072] [MGI Ref ID J:140379]
Oertli M; Sundquist M; Hitzler I; Engler DB; Arnold IC; Reuter S; Maxeiner J; Hansson M; Taube C; Quiding-Jarbrink M; Muller A. 2012. DC-derived IL-18 drives Treg differentiation, murine Helicobacter pylori-specific immune tolerance, and asthma protection. J Clin Invest 122(3):1082-96. [PubMed: 22307326] [MGI Ref ID J:184486]
Ohteki T; Tada H; Ishida K; Sato T; Maki C; Yamada T; Hamuro J; Koyasu S. 2006. Essential roles of DC-derived IL-15 as a mediator of inflammatory responses in vivo. J Exp Med 203(10):2329-38. [PubMed: 16966429] [MGI Ref ID J:124624]
Osterholzer JJ; Milam JE; Chen GH; Toews GB; Huffnagle GB; Olszewski MA. 2009. Role of dendritic cells and alveolar macrophages in regulating early host defense against pulmonary infection with Cryptococcus neoformans. Infect Immun 77(9):3749-58. [PubMed: 19564388] [MGI Ref ID J:152249]
Ouchi T; Kubo A; Yokouchi M; Adachi T; Kobayashi T; Kitashima DY; Fujii H; Clausen BE; Koyasu S; Amagai M; Nagao K. 2011. Langerhans cell antigen capture through tight junctions confers preemptive immunity in experimental staphylococcal scalded skin syndrome. J Exp Med 208(13):2607-13. [PubMed: 22143886] [MGI Ref ID J:179051]
Padilla J; Daley E; Chow A; Robinson K; Parthasarathi K; McKenzie AN; Tschernig T; Kurup VP; Donaldson DD; Grunig G. 2005. IL-13 regulates the immune response to inhaled antigens. J Immunol 174(12):8097-105. [PubMed: 15944318] [MGI Ref ID J:100867]
Park SJ; Burdick MD; Mehrad B. 2012. Neutrophils Mediate Maturation and Efflux of Lung Dendritic Cells in Response to Aspergillus fumigatus Germ Tubes. Infect Immun 80(5):1759-65. [PubMed: 22392929] [MGI Ref ID J:182680]
Patsouris D; Li PP; Thapar D; Chapman J; Olefsky JM; Neels JG. 2008. Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell Metab 8(4):301-9. [PubMed: 18840360] [MGI Ref ID J:143426]
Paulson KE; Zhu SN; Chen M; Nurmohamed S; Jongstra-Bilen J; Cybulsky MI. 2010. Resident intimal dendritic cells accumulate lipid and contribute to the initiation of atherosclerosis. Circ Res 106(2):383-90. [PubMed: 19893012] [MGI Ref ID J:170071]
Paveglio SA; Allard J; Foster Hodgkins SR; Ather JL; Bevelander M; Campbell JM; Whittaker LeClair LA; McCarthy SM; van der Vliet A; Suratt BT; Boyson JE; Uematsu S; Akira S; Poynter ME. 2011. Airway epithelial indoleamine 2,3-dioxygenase inhibits CD4+ T cells during Aspergillus fumigatus antigen exposure. Am J Respir Cell Mol Biol 44(1):11-23. [PubMed: 20118221] [MGI Ref ID J:186825]
Plaks V; Birnberg T; Berkutzki T; Sela S; BenYashar A; Kalchenko V; Mor G; Keshet E; Dekel N; Neeman M; Jung S. 2008. Uterine DCs are crucial for decidua formation during embryo implantation in mice. J Clin Invest 118(12):3954-65. [PubMed: 19033665] [MGI Ref ID J:144732]
Poeck H; Besch R; Maihoefer C; Renn M; Tormo D; Morskaya SS; Kirschnek S; Gaffal E; Landsberg J; Hellmuth J; Schmidt A; Anz D; Bscheider M; Schwerd T; Berking C; Bourquin C; Kalinke U; Kremmer E; Kato H; Akira S; Meyers R; Hacker G; Neuenhahn M; Busch D;Ruland J; Rothenfusser S; Prinz M; Hornung V; Endres S; Tuting T; Hartmann G. 2008. 5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma. Nat Med 14(11):1256-63. [PubMed: 18978796] [MGI Ref ID J:143226]
Probst HC; Tschannen K; Odermatt B; Schwendener R; Zinkernagel RM; Van Den Broek M. 2005. Histological analysis of CD11c-DTR/GFP mice after in vivo depletion of dendritic cells. Clin Exp Immunol 141(3):398-404. [PubMed: 16045728] [MGI Ref ID J:106223]
Probst HC; van den Broek M. 2005. Priming of CTLs by lymphocytic choriomeningitis virus depends on dendritic cells. J Immunol 174(7):3920-4. [PubMed: 15778347] [MGI Ref ID J:97970]
Qing X; Koo GC; Salmon JE. 2012. Complement regulates conventional DC-mediated NK-cell activation by inducing TGF-beta1 in Gr-1+ myeloid cells. Eur J Immunol 42(7):1723-34. [PubMed: 22535677] [MGI Ref ID J:187776]
Qiu X; Zhu L; Pollard JW. 2009. Colony-stimulating factor-1-dependent macrophage functions regulate the maternal decidua immune responses against Listeria monocytogenes infections during early gestation in mice. Infect Immun 77(1):85-97. [PubMed: 18852237] [MGI Ref ID J:144590]
Rahman S; Manuel SL; Khan ZK; Wigdahl B; Acheampong E; Tangy F; Jain P. 2010. Depletion of dendritic cells enhances susceptibility to cell-free infection of human T cell leukemia virus type 1 in CD11c-diphtheria toxin receptor transgenic mice. J Immunol 184(10):5553-61. [PubMed: 20382884] [MGI Ref ID J:161006]
Rangel-Moreno J; Carragher DM; de la Luz Garcia-Hernandez M; Hwang JY; Kusser K; Hartson L; Kolls JK; Khader SA; Randall TD. 2011. The development of inducible bronchus-associated lymphoid tissue depends on IL-17. Nat Immunol 12(7):639-46. [PubMed: 21666689] [MGI Ref ID J:174312]
Rivera A; Hohl TM; Collins N; Leiner I; Gallegos A; Saijo S; Coward JW; Iwakura Y; Pamer EG. 2011. Dectin-1 diversifies Aspergillus fumigatus-specific T cell responses by inhibiting T helper type 1 CD4 T cell differentiation. J Exp Med 208(2):369-81. [PubMed: 21242294] [MGI Ref ID J:176853]
Rivollier A; He J; Kole A; Valatas V; Kelsall BL. 2012. Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon. J Exp Med 209(1):139-55. [PubMed: 22231304] [MGI Ref ID J:181701]
Robb RJ; Lineburg KE; Kuns RD; Wilson YA; Raffelt NC; Olver SD; Varelias A; Alexander KA; Teal BE; Sparwasser T; Hammerling GJ; Markey KA; Koyama M; Clouston AD; Engwerda CR; Hill GR; MacDonald KP. 2012. Identification and expansion of highly suppressive CD8(+)FoxP3(+) regulatory T cells after experimental allogeneic bone marrow transplantation. Blood 119(24):5898-908. [PubMed: 22538855] [MGI Ref ID J:188644]
Robinson RT; Khader SA; Martino CA; Fountain JJ; Teixeira-Coelho M; Pearl JE; Smiley ST; Winslow GM; Woodland DL; Walter MJ; Conejo-Garcia JR; Gubler U; Cooper AM. 2010. Mycobacterium tuberculosis infection induces il12rb1 splicing to generate a novel IL-12Rbeta1 isoform that enhances DC migration. J Exp Med 207(3):591-605. [PubMed: 20212068] [MGI Ref ID J:158809]
Salazar-Gonzalez RM; Niess JH; Zammit DJ; Ravindran R; Srinivasan A; Maxwell JR; Stoklasek T; Yadav R; Williams IR; Gu X; McCormick BA; Pazos MA; Vella AT; Lefrancois L; Reinecker HC; McSorley SJ. 2006. CCR6-mediated dendritic cell activation of pathogen-specific T cells in Peyer's patches. Immunity 24(5):623-32. [PubMed: 16713979] [MGI Ref ID J:113363]
Sapoznikov A; Fischer JA; Zaft T; Krauthgamer R; Dzionek A; Jung S. 2007. Organ-dependent in vivo priming of naive CD4+, but not CD8+, T cells by plasmacytoid dendritic cells. J Exp Med 204(8):1923-33. [PubMed: 17646404] [MGI Ref ID J:125954]
Sapoznikov A; Pewzner-Jung Y; Kalchenko V; Krauthgamer R; Shachar I; Jung S. 2008. Perivascular clusters of dendritic cells provide critical survival signals to B cells in bone marrow niches. Nat Immunol 9(4):388-95. [PubMed: 18311142] [MGI Ref ID J:133263]
Saxena V; Ondr JK; Magnusen AF; Munn DH; Katz JD. 2007. The countervailing actions of myeloid and plasmacytoid dendritic cells control autoimmune diabetes in the nonobese diabetic mouse. J Immunol 179(8):5041-53. [PubMed: 17911589] [MGI Ref ID J:137009]
Schindler D; Gutierrez MG; Beineke A; Rauter Y; Rohde M; Foster S; Goldmann O; Medina E. 2012. Dendritic Cells Are Central Coordinators of the Host Immune Response to Staphylococcus aureus Bloodstream Infection. Am J Pathol 181(4):1327-37. [PubMed: 22885107] [MGI Ref ID J:188587]
Schleicher U; Liese J; Knippertz I; Kurzmann C; Hesse A; Heit A; Fischer JA; Weiss S; Kalinke U; Kunz S; Bogdan C. 2007. NK cell activation in visceral leishmaniasis requires TLR9, myeloid DCs, and IL-12, but is independent of plasmacytoid DCs. J Exp Med 204(4):893-906. [PubMed: 17389237] [MGI Ref ID J:125611]
Schmieg J; Yang G; Franck RW; Van Rooijen N; Tsuji M. 2005. Glycolipid presentation to natural killer T cells differs in an organ-dependent fashion. Proc Natl Acad Sci U S A 102(4):1127-32. [PubMed: 15644449] [MGI Ref ID J:96123]
Scholz J; Lukacs-Kornek V; Engel DR; Specht S; Kiss E; Eitner F; Floege J; Groene HJ; Kurts C. 2008. Renal dendritic cells stimulate IL-10 production and attenuate nephrotoxic nephritis. J Am Soc Nephrol 19(3):527-37. [PubMed: 18235094] [MGI Ref ID J:150170]
Scumpia PO; McAuliffe PF; O'Malley KA; Ungaro R; Uchida T; Matsumoto T; Remick DG; Clare-Salzler MJ; Moldawer LL; Efron PA. 2005. CD11c+ dendritic cells are required for survival in murine polymicrobial sepsis. J Immunol 175(5):3282-6. [PubMed: 16116220] [MGI Ref ID J:113232]
Shaw CA; Starnbach MN. 2006. Stimulation of CD8+ T cells following diphtheria toxin-mediated antigen delivery into dendritic cells. Infect Immun 74(2):1001-8. [PubMed: 16428746] [MGI Ref ID J:105010]
Snelgrove SL; Kausman JY; Lo C; Lo C; Ooi JD; Coates PT; Hickey MJ; Holdsworth SR; Kurts C; Engel DR; Kitching AR. 2012. Renal dendritic cells adopt a pro-inflammatory phenotype in obstructive uropathy to activate T cells but do not directly contribute to fibrosis. Am J Pathol 180(1):91-103. [PubMed: 22079432] [MGI Ref ID J:180211]
Soderquest K; Powell N; Luci C; van Rooijen N; Hidalgo A; Geissmann F; Walzer T; Lord GM; Martin-Fontecha A. 2011. Monocytes control natural killer cell differentiation to effector phenotypes. Blood 117(17):4511-8. [PubMed: 21389319] [MGI Ref ID J:172809]
Soudja SM; Ruiz AL; Marie JC; Lauvau G. 2012. Inflammatory Monocytes Activate Memory CD8(+) T and Innate NK Lymphocytes Independent of Cognate Antigen during Microbial Pathogen Invasion. Immunity 37(3):549-62. [PubMed: 22940097] [MGI Ref ID J:187687]
Steel CD; Hahto SM; Ciavarra RP. 2009. Peripheral dendritic cells are essential for both the innate and adaptive antiviral immune responses in the central nervous system. Virology 387(1):117-26. [PubMed: 19264338] [MGI Ref ID J:157148]
Tadagavadi RK; Reeves WB. 2010. Renal dendritic cells ameliorate nephrotoxic acute kidney injury. J Am Soc Nephrol 21(1):53-63. [PubMed: 19875815] [MGI Ref ID J:185867]
Tait ED; Jordan KA; Dupont CD; Harris TH; Gregg B; Wilson EH; Pepper M; Dzierszinski F; Roos DS; Hunter CA. 2010. Virulence of Toxoplasma gondii is associated with distinct dendritic cell responses and reduced numbers of activated CD8+ T cells. J Immunol 185(3):1502-12. [PubMed: 20592284] [MGI Ref ID J:162456]
Tang H; Cao W; Kasturi SP; Ravindran R; Nakaya HI; Kundu K; Murthy N; Kepler TB; Malissen B; Pulendran B. 2010. The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling. Nat Immunol 11(7):608-17. [PubMed: 20495560] [MGI Ref ID J:161857]
Tatum AM; Watson AM; Schell TD. 2010. Direct presentation regulates the magnitude of the CD8(+) T cell response to cell-associated antigen through prolonged T cell proliferation. J Immunol 185(5):2763-72. [PubMed: 20660711] [MGI Ref ID J:163267]
Terme M; Mignot G; Ullrich E; Bonmort M; Minard-Colin V; Jacquet A; Schultze JL; Kroemer G; Leclerc C; Chaput N; Zitvogel L. 2009. The dendritic cell-like functions of IFN-producing killer dendritic cells reside in the CD11b+ subset and are licensed by tumor cells. Cancer Res 69(16):6590-7. [PubMed: 19679551] [MGI Ref ID J:151930]
Tian T; Woodworth J; Skold M; Behar SM. 2005. In vivo depletion of CD11c+ cells delays the CD4+ T cell response to Mycobacterium tuberculosis and exacerbates the outcome of infection. J Immunol 175(5):3268-72. [PubMed: 16116218] [MGI Ref ID J:113231]
Tittel AP; Heuser C; Ohliger C; Llanto C; Yona S; Hammerling GJ; Engel DR; Garbi N; Kurts C. 2012. Functionally relevant neutrophilia in CD11c diphtheria toxin receptor transgenic mice. Nat Methods 9(4):385-90. [PubMed: 22367054] [MGI Ref ID J:194800]
Tortola L; Rosenwald E; Abel B; Blumberg H; Schafer M; Coyle AJ; Renauld JC; Werner S; Kisielow J; Kopf M. 2012. Psoriasiform dermatitis is driven by IL-36-mediated DC-keratinocyte crosstalk. J Clin Invest 122(11):3965-76. [PubMed: 23064362] [MGI Ref ID J:193548]
Tzeng TC; Chyou S; Tian S; Webster B; Carpenter AC; Guaiquil VH; Lu TT. 2010. CD11chi dendritic cells regulate the re-establishment of vascular quiescence and stabilization after immune stimulation of lymph nodes. J Immunol 184(8):4247-57. [PubMed: 20231692] [MGI Ref ID J:159876]
Unkel B; Hoegner K; Clausen BE; Lewe-Schlosser P; Bodner J; Gattenloehner S; Janssen H; Seeger W; Lohmeyer J; Herold S. 2012. Alveolar epithelial cells orchestrate DC function in murine viral pneumonia. J Clin Invest 122(10):3652-64. [PubMed: 22996662] [MGI Ref ID J:191753]
Vallon-Eberhard A; Landsman L; Yogev N; Verrier B; Jung S. 2006. Transepithelial pathogen uptake into the small intestinal lamina propria. J Immunol 176(4):2465-9. [PubMed: 16456006] [MGI Ref ID J:106225]
Van Maele L; Carnoy C; Cayet D; Songhet P; Dumoutier L; Ferrero I; Janot L; Erard F; Bertout J; Leger H; Sebbane F; Benecke A; Renauld JC; Hardt WD; Ryffel B; Sirard JC. 2010. TLR5 signaling stimulates the innate production of IL-17 and IL-22 by CD3(neg)CD127+ immune cells in spleen and mucosa. J Immunol 185(2):1177-85. [PubMed: 20566828] [MGI Ref ID J:162022]
Varol C; Landsman L; Fogg DK; Greenshtein L; Gildor B; Margalit R; Kalchenko V; Geissmann F; Jung S. 2007. Monocytes give rise to mucosal, but not splenic, conventional dendritic cells. J Exp Med 204(1):171-80. [PubMed: 17190836] [MGI Ref ID J:125312]
Varol C; Vallon-Eberhard A; Elinav E; Aychek T; Shapira Y; Luche H; Fehling HJ; Hardt WD; Shakhar G; Jung S. 2009. Intestinal lamina propria dendritic cell subsets have different origin and functions. Immunity 31(3):502-12. [PubMed: 19733097] [MGI Ref ID J:152689]
Veiga-Fernandes H; Coles MC; Foster KE; Patel A; Williams A; Natarajan D; Barlow A; Pachnis V; Kioussis D. 2007. Tyrosine kinase receptor RET is a key regulator of Peyer's patch organogenesis. Nature 446(7135):547-51. [PubMed: 17322904] [MGI Ref ID J:120816]
Venet F; Chung CS; Huang X; Lomas-Neira J; Chen Y; Ayala A. 2009. Lymphocytes in the development of lung inflammation: a role for regulatory CD4+ T cells in indirect pulmonary lung injury. J Immunol 183(5):3472-80. [PubMed: 19641139] [MGI Ref ID J:151875]
Venet F; Huang X; Chung CS; Chen Y; Ayala A. 2010. Plasmacytoid dendritic cells control lung inflammation and monocyte recruitment in indirect acute lung injury in mice. Am J Pathol 176(2):764-73. [PubMed: 20042672] [MGI Ref ID J:156596]
Verschoor A; Neuenhahn M; Navarini AA; Graef P; Plaumann A; Seidlmeier A; Nieswandt B; Massberg S; Zinkernagel RM; Hengartner H; Busch DH. 2011. A platelet-mediated system for shuttling blood-borne bacteria to CD8alpha+ dendritic cells depends on glycoprotein GPIb and complement C3. Nat Immunol 12(12):1194-201. [PubMed: 22037602] [MGI Ref ID J:179014]
Villablanca EJ; Raccosta L; Zhou D; Fontana R; Maggioni D; Negro A; Sanvito F; Ponzoni M; Valentinis B; Bregni M; Prinetti A; Steffensen KR; Sonnino S; Gustafsson JA; Doglioni C; Bordignon C; Traversari C; Russo V. 2010. Tumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses. Nat Med 16(1):98-105. [PubMed: 20037595] [MGI Ref ID J:155862]
Wakkach A; Mansour A; Dacquin R; Coste E; Jurdic P; Carle GF; Blin-Wakkach C. 2008. Bone marrow microenvironment controls the in vivo differentiation of murine dendritic cells into osteoclasts. Blood 112(13):5074-83. [PubMed: 18768394] [MGI Ref ID J:143799]
Wallet MA; Sen P; Flores RR; Wang Y; Yi Z; Huang Y; Mathews CE; Earp HS; Matsushima G; Wang B; Tisch R. 2008. MerTK is required for apoptotic cell-induced T cell tolerance. J Exp Med 205(1):219-32. [PubMed: 18195070] [MGI Ref ID J:131291]
Wang H; Wu X; Wang Y; Oldenborg PA; Yang YG. 2010. CD47 is required for suppression of allograft rejection by donor-specific transfusion. J Immunol 184(7):3401-7. [PubMed: 20208011] [MGI Ref ID J:160062]
Wathne GJ; Kissenpfennig A; Malissen B; Zurzolo C; Mabbott NA. 2012. Determining the role of mononuclear phagocytes in prion neuroinvasion from the skin. J Leukoc Biol 91(5):817-28. [PubMed: 22389312] [MGI Ref ID J:183759]
Willart MA; Jan de Heer H; Hammad H; Soullie T; Deswarte K; Clausen BE; Boon L; Hoogsteden HC; Lambrecht BN. 2009. The lung vascular filter as a site of immune induction for T cell responses to large embolic antigen. J Exp Med 206(12):2823-35. [PubMed: 19858325] [MGI Ref ID J:154860]
Winter S; Rehm A; Wichner K; Scheel T; Batra A; Siegmund B; Berek C; Lipp M; Hopken UE. 2011. Manifestation of Spontaneous and Early Autoimmune Gastritis in CCR7-Deficient Mice. Am J Pathol 179(2):754-65. [PubMed: 21801869] [MGI Ref ID J:174601]
Wu HJ; Sawaya H; Binstadt B; Brickelmaier M; Blasius A; Gorelik L; Mahmood U; Weissleder R; Carulli J; Benoist C; Mathis D. 2007. Inflammatory arthritis can be reined in by CpG-induced DC-NK cell cross talk. J Exp Med 204(8):1911-22. [PubMed: 17646407] [MGI Ref ID J:125952]
Yao S; Wang S; Zhu Y; Luo L; Zhu G; Flies S; Xu H; Ruff W; Broadwater M; Choi IH; Tamada K; Chen L. 2009. PD-1 on dendritic cells impedes innate immunity against bacterial infection. Blood 113(23):5811-8. [PubMed: 19339692] [MGI Ref ID J:149357]
Zaft T; Sapoznikov A; Krauthgamer R; Littman DR; Jung S. 2005. CD11chigh dendritic cell ablation impairs lymphopenia-driven proliferation of naive and memory CD8+ T cells. J Immunol 175(10):6428-35. [PubMed: 16272295] [MGI Ref ID J:106224]
Zammit DJ; Cauley LS; Pham QM; Lefrancois L. 2005. Dendritic cells maximize the memory CD8 T cell response to infection. Immunity 22(5):561-70. [PubMed: 15894274] [MGI Ref ID J:106222]
Zanoni I; Ostuni R; Barresi S; Di Gioia M; Broggi A; Costa B; Marzi R; Granucci F. 2012. CD14 and NFAT mediate lipopolysaccharide-induced skin edema formation in mice. J Clin Invest 122(5):1747-57. [PubMed: 22466648] [MGI Ref ID J:184542]
Zhang L; Bridle BW; Chen L; Pol J; Spaner D; Boudreau JE; Rosen A; Bassett JD; Lichty BD; Bramson JL; Wan Y. 2013. Delivery of viral-vectored vaccines by B cells represents a novel strategy to accelerate CD8(+) T-cell recall responses. Blood 121(13):2432-9. [PubMed: 23325836] [MGI Ref ID J:195882]
Zigmond E; Varol C; Farache J; Elmaliah E; Satpathy AT; Friedlander G; Mack M; Shpigel N; Boneca IG; Murphy KM; Shakhar G; Halpern Z; Jung S. 2012. Ly6C(hi) Monocytes in the Inflamed Colon Give Rise to Proinflammatory Effector Cells and Migratory Antigen-Presenting Cells. Immunity 37(6):1076-90. [PubMed: 23219392] [MGI Ref ID J:191054]
de Goer de Herve MG; Dembele B; Vallee M; Herr F; Cariou A; Taoufik Y. 2010. Direct CD4 help provision following interaction of memory CD4 and CD8 T cells with distinct antigen-presenting dendritic cells. J Immunol 185(2):1028-36. [PubMed: 20562265] [MGI Ref ID J:162023]
de Jong JM; Schuurhuis DH; Ioan-Facsinay A; Welling MM; Camps MG; van der Voort EI; Huizinga TW; Ossendorp F; Verbeek JS; Toes RE. 2006. Dendritic cells, but not macrophages or B cells, activate major histocompatibility complex class II-restricted CD4+ T cells upon immune-complex uptake in vivo. Immunology 119(4):499-506. [PubMed: 16995881] [MGI Ref ID J:118521]
de Vries VC; Pino-Lagos K; Nowak EC; Bennett KA; Oliva C; Noelle RJ. 2011. Mast cells condition dendritic cells to mediate allograft tolerance. Immunity 35(4):550-61. [PubMed: 22035846] [MGI Ref ID J:177851]
van Rijt LS; Jung S; Kleinjan A; Vos N; Willart M; Duez C; Hoogsteden HC; Lambrecht BN. 2005. In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma. J Exp Med 201(6):981-91. [PubMed: 15781587] [MGI Ref ID J:106221]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX12
Colony Maintenance
Breeding & Husbandry When maintaining a live colony, hemizygous (carrier) mice may be bred with wildtype (noncarrier) mice from the colony or with C57BL/6J inbred mice. The coat color expected from breeding is black. Mating System Inbred x Hemizygote (Female x Male) 01-MAR-06 Diet Information LabDiet® 5K52/5K67
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $232.00 Female or Male Hemizygous for Tg(Itgax-DTR/EGFP)57Lan
Price per Pair (US dollars $) Pair Genotype $252.40 C57BL/6J (000664) x Hemizygous for Tg(Itgax-DTR/EGFP)57Lan $250.90 Hemizygous for Tg(Itgax-DTR/EGFP)57Lan x C57BL/6J (000664) Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
| Pricing for International shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $301.60 Female or Male Hemizygous for Tg(Itgax-DTR/EGFP)57Lan
Price per Pair (US dollars $) Pair Genotype $328.20 C57BL/6J (000664) x Hemizygous for Tg(Itgax-DTR/EGFP)57Lan $326.20 Hemizygous for Tg(Itgax-DTR/EGFP)57Lan x C57BL/6J (000664) Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
|
|
|
Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form
Terms of Use
Terms of Use
General Terms and Conditions
For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.
Contact information
General inquiries regarding Terms of UseContracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.