Strain Name:

C.FVB-Tg(Itgax-DTR/EGFP)57Lan/J

Stock Number:

004512

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Availability:

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These transgenic mice contain a simian diphtheria toxin receptor and green fluorescent fusion protein under the control of the mouse Itgax promoter, and expression of the transgene is specific to splenic dendritic cells. This mutant mouse strain may be useful in studies of mononuclear phagocyte origins and the specific role of dendritic cells in the immune response.

Description

Strain Information

Former Names C.FVB-Tg(Itgax-DTR/GFP)57Drl    (Changed: 15-DEC-04 )
C.FVB-Tg(Itgax-DTR/GFP)57Lan/J    (Changed: 15-DEC-04 )
C.FVB-Tg(Itgax-DTR/GFP)57Litt    (Changed: 15-DEC-04 )
CD11c-DTR    (Changed: 15-DEC-04 )
Type Congenic; Mutant Strain; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Mating SystemInbred x Hemizygote         (Female x Male)   01-MAR-06
Specieslaboratory mouse
GenerationN8+N26 (10-DEC-13)
Generation Definitions
 
Donating InvestigatorDr. Dan R. Littman,   New York University Medical Center

Description
Mice that are homozygous for the transgene are viable, normal in size and do not display any gross physical or behavioral abnormalities. Upon diphtheria toxin (DT) administration, mice harboring this transgene are transiently depleted of dendritic cell (DC) populations. All CD8+ and CD8- DC in the spleen express EGFP and are DT sensitive. Immunohistochemical and flow cytometric analysis reveals EGFP expression and DT-inducible depletion of CD11chigh DC in spleen, lymph node, lung, liver and lamina propria tissues, as well as the defined macrophage subpopulations of the alveolar, lamina propria, metallophillic and marginal zone. Rapid reduction of CD11c+ DC populations induced by intraperitoneal injection of DT persists for approximately 2 days, after which the cell population gradually recovers. While transient DC depletion was not associated with sign of illness or long-term defects, repeated DT induction is lethal to the mouse. Long term depletion of this cell population can be achieved by the generation of mixed irradiation chimeras. This mutant mouse strain may be useful in studies of mononuclear phagocyte origins and the specific role of dendritic cells in the immune response.

In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.

Development
A transgene was designed to place a simian Diphtheria Toxin Receptor (DTR)-Enhanced Green Fluorescent Protein (EGFP, Stratagene) fusion protein under the control of the Itgax (or CD11c) promoter. This transgene was introduced into fertilized FVB/N donor eggs. The resulting chimeric animals were crossed to BALB/c mice, and then backcrossed to BALB/c for 8 generations. This transgene has been mapped to mouse Chromosome 1 (~52 cM; 87395187bp position) via single nucleotide polymorphism (SNP) analysis by The Jackson Laboratory.

Control Information

  Control
   Noncarrier
   000651 BALB/cJ
 
  Considerations for Choosing Controls

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009655   C57BL/6J-Tg(Dcx-DsRed)14Qlu/J
007857   C57BL/6J-Tg(Eno2-YFP/Cox8a)YRwb/J
007860   C57BL/6J-Tg(Eno2-YFP/Cox8a)ZRwb/J
007567   C57BL/6J-Tg(Itgax-cre,-EGFP)4097Ach/J
009593   C57BL/6J-Tg(Pomc-EGFP)1Low/J
003927   C57BL/6J-Tg(Sry-EGFP)92Ei/EiJ
008234   CB6-Tg(CAG-EGFP/CETN2)3-4Jgg/J
007677   CB6-Tg(Gad1-EGFP)G42Zjh/J
007898   CBy.Cg-Tg(Gt(ROSA)26Sor-EGFP)I1Able/J
007075   CByJ.B6-Tg(CAG-EGFP)1Osb/J
007076   CByJ.B6-Tg(UBC-GFP)30Scha/J
010548   D1.FVB(Cg)-Tg(CAG-luc,-GFP)L2G85Chco/FathJ
008450   FVB-Tg(CAG-luc,-GFP)L2G85Chco/J
003718   FVB-Tg(GadGFP)45704Swn/J
010947   FVB-Tg(Gstm5-EGFP)1Ilis/J
005515   FVB-Tg(ITGAM-DTR/EGFP)34Lan/J
010588   FVB-Tg(Myh6/NFAT-luc)1Jmol/J
006421   FVB-Tg(Pomc1-hrGFP)1Lowl/J
005688   FVB-Tg(Rag2-EGFP)1Mnz/J
005125   FVB.129S6(B6)-Gt(ROSA)26Sortm1(Luc)Kael/J
006206   FVB.129S6-Gt(ROSA)26Sortm2(HIF1A/luc)Kael/J
012429   FVB.Cg-Gt(ROSA)26Sortm1(CAG-lacZ,-EGFP)Glh/J
003516   FVB.Cg-Tg(CAG-EGFP)B5Nagy/J
016573   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(S100B-EGFP)1Wjt Tg(SMN2*delta7)4299Ahmb/J
007483   FVB.Cg-Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
008200   FVB/N-Tg(CAG-EGFP,-ALPP)2.6Ggc/J
009354   FVB/N-Tg(Dazl-EGFP)10Rarp/J
003257   FVB/N-Tg(GFAPGFP)14Mes/J
007800   FVB/N-Tg(Ins1-luc)VUPwrs/J
012370   FVB/NJ-Tg(Hspa1a-luc,-EGFP)2Chco/J
009618   NOD.129(B6)-Il12btm1Lky/JbsJ
013116   NOD.B6-Tg(Ins2-luc/EGFP/TK)300Kauf/J
013233   NOD.B6-Tg(Itgax-cre,-EGFP)4097Ach/J
006698   NOD.Cg-Il4tm1Lky/JbsJ
008173   NOD.Cg-Tg(Ins1-EGFP)1Hara/QtngJ
009422   NOD.Cg-Tg(Itgax-Venus)1Mnz/QtngJ
005076   NOD.Cg-Tg(tetO-EGFP/FADD)1Doi/DoiJ
010542   NOD.FVB-Tg(CAG-luc,-GFP)L2G85Chco/FathJ
008547   NOD.FVB-Tg(ITGAM-DTR/EGFP)34Lan/JdkJ
008549   NOD.FVB-Tg(Itgax-DTR/EGFP)57Lan/JdkJ
005082   NOD/ShiLt-Tg(ACTB-Ica1/EGFP)18Mdos/MdosJ
005328   NOD/ShiLt-Tg(Cd4-DsRed)4Lt/J
005334   NOD/ShiLt-Tg(Cd4-EGFP)1Lt/J
008694   NOD/ShiLt-Tg(Foxp3-EGFP/cre)1cJbs/J
005282   NOD/ShiLtJ-Tg(Ins1-EGFP/GH1)14Hara/HaraJ
012881   STOCK Ascl1tm1Reed/J
008666   STOCK Fmn1tm1Made/J
013731   STOCK Gt(ROSA)26Sortm1(CAG-Brainbow2.1)Cle/J
006331   STOCK Gt(ROSA)26Sortm1(DTA)Jpmb/J
005130   STOCK Gt(ROSA)26Sortm1(Smo/EYFP)Amc/J
005572   STOCK Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/J
017922   STOCK Gt(ROSA)26Sortm10(ACTB-tdTomato)Luo/J
018903   STOCK Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
007576   STOCK Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/J
024107   STOCK Gt(ROSA)26Sortm5(ACTB-tTA)Luo Igs7tm93.1(tetO-GCaMP6f)Hze/HzeJ
017912   STOCK Gt(ROSA)26Sortm6(ACTB-EGFP*,-tdTomato)Luo/J
017921   STOCK Gt(ROSA)26Sortm7(ACTB-EGFP*)Luo/J
017909   STOCK Gt(ROSA)26Sortm8(ACTB-EGFP*,-tTA2)Luo/J
008876   STOCK Hprttm11(Ple176-EGFP/cre)Ems/Mmjax
009349   STOCK Hprttm31(Ple67-EGFP)Ems/Mmjax
009594   STOCK Hprttm32(Ple112-EGFP)Ems/Mmjax
022976   STOCK Igs2tm1(ACTB-EGFP,-tdTomato)Zng/J
022977   STOCK Igs2tm2(ACTB-tdTomato,-EGFP)Zng/J
013749   STOCK Iis2tm1(ACTB-EGFP,-tdTomato)Luo/J
013751   STOCK Iis2tm2(ACTB-tdTomato,-EGFP)Luo/J
017932   STOCK Iis3tm1.1(ACTB-EGFP*)Luo/J
017923   STOCK Iis3tm2.1(ACTB-EGFP*,-tdTomato)Luo/J
021458   STOCK Iis5tm1(ACTB-tdTomato,-EGFP)Luo/J
021457   STOCK Iis5tm2.1(ACTB-EGFP,-tdTomato)Luo/J
021461   STOCK Iis6tm1.1(ACTB-tdTomato,-EFGP)Luo/J
021460   STOCK Iis6tm2.1(ACTB-EFGP,-tdTomato)Luo/J
004808   STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
004779   STOCK Mapttm1(EGFP)Klt/J
005692   STOCK Nphs1tm1Rkl/J
006741   STOCK Olfr160tm1(Olfr151)Mom Tg(Olfr151,taulacZ)BMom/MomJ
006678   STOCK Olfr160tm6Mom/MomJ
006669   STOCK Olfr17tm7Mom/MomJ
009061   STOCK Osr1tm1(EGFP/cre/ERT2)Amc/J
007879   STOCK Stx1atm2Sud/J
014581   STOCK Trpm8tm1Apat/J
010911   STOCK Wt1tm1(EGFP/cre)Wtp/J
005438   STOCK Tg(CAG-Bgeo,-DsRed*MST)1Nagy/J
006850   STOCK Tg(CAG-Bgeo,-NOTCH1,-EGFP)1Lbe/J
006876   STOCK Tg(CAG-Bgeo,-TEL/AML1,-EGFP)A6Lbe/J
003920   STOCK Tg(CAG-Bgeo/GFP)21Lbe/J
005441   STOCK Tg(CAG-DsRed*MST)1Nagy/J
003773   STOCK Tg(CAG-ECFP)CK6Nagy/J
003115   STOCK Tg(CAG-EGFP)B5Nagy/J
003116   STOCK Tg(CAG-EGFP)D4Nagy/J
011106   STOCK Tg(CAG-GFP*)1Hadj/J
013754   STOCK Tg(CAG-KikGR)75Hadj/J
011107   STOCK Tg(CAG-Venus)1Hadj/J
005645   STOCK Tg(CAG-mRFP1)1F1Hadj/J
005105   STOCK Tg(Chx10-EGFP/cre,-ALPP)2Clc/J
018322   STOCK Tg(Cp-EGFP)25Gaia/ReyaJ
008241   STOCK Tg(Cspg4-DsRed.T1)1Akik/J
006334   STOCK Tg(Gad1-EGFP)94Agmo/J
006340   STOCK Tg(Gad1-EGFP)98Agmo/J
007896   STOCK Tg(Gt(ROSA)26Sor-EGFP)I1Able/J
016252   STOCK Tg(Hoxb7-Venus*)17Cos/J
006784   STOCK Tg(Ins1-Cerulean)24Hara/J
006866   STOCK Tg(Ins1-DsRed*T4)32Hara/J
016921   STOCK Tg(Myh2-DsRed2)1Jrs/J
012477   STOCK Tg(Myh6*/tetO-GCaMP2)1Mik/J
016922   STOCK Tg(Myh7-CFP)1Jrs/J
008579   STOCK Tg(PSCA-EGFP)1Witt/J
012452   STOCK Tg(Rr5-GFP/cre)1Sapc/J
006570   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(Hlxb9-GFP)1Tmj/J
009606   STOCK Tg(Six2-EGFP/cre)1Amc/J
003658   STOCK Tg(TIE2GFP)287Sato/J
013162   STOCK Tg(Thy1-Clomeleon)12Gjau/J
013163   STOCK Tg(Thy1-Clomeleon)13Gjau/J
007788   STOCK Tg(Thy1-EGFP)MJrs/J
012708   STOCK Tg(Thy1-cre/ERT2,-EYFP)HGfng/PyngJ
011108   STOCK Tg(Ttr-RFP)1Hadj/J
016981   STOCK Tg(Uchl1-HIST2H2BE/mCherry/EGFP*)FSout/J
006129   STOCK Tg(Zp3-EGFP)1Dean/J
003274   STOCK Tg(tetNZL)2Bjd/J
005104   STOCK Tg(tetO-HIST1H2BJ/GFP)47Efu/J
005699   STOCK Tg(tetO-Ipf1,EGFP)956.6Macd/J
017918   STOCK Tg(tetO-MAML1*/EGFP)2Akar/J
012345   STOCK Tg(tetO-tdTomato,-Syp/EGFP*)1.1Luo/J
View Fluorescent Protein Strains     (377 strains)

Strains carrying   Tg(Itgax-DTR/EGFP)57Lan allele
004509   B6.FVB-Tg(Itgax-DTR/EGFP)57Lan/J
008549   NOD.FVB-Tg(Itgax-DTR/EGFP)57Lan/JdkJ
View Strains carrying   Tg(Itgax-DTR/EGFP)57Lan     (2 strains)

Strains carrying other alleles of GFP
006053   129-Gt(ROSA)26Sortm1(CAG-EGFP)Luo/J
006067   129-Gt(ROSA)26Sortm2(CAG-Dsred2/EGFP)Luo/J
006041   129-Gt(ROSA)26Sortm3(CAG-EGFP/Dsred2)Luo/J
016925   129;B6-Grin3b/Tmem259tm1Zhang Tg(Prnp-C19ORF6,-GFP)6Zhang/J
016251   129S.Cg-Tg(Hoxb7-EGFP)33Cos/J
003960   129S6-Tg(Prnp-GFP/cre)1Blw/J
017458   B6(C)-Tg(UAS-EGFP,-SOD1*G37R)135Gsn/J
017460   B6(C)-Tg(UAS-EGFP,-SOD1*G37R)677Gsn/J
008242   B6(Cg)-Gt(ROSA)26Sortm4(Ikbkb)Rsky/J
021011   B6(D2)-Tg(CAG-Brainbow1.0)2Eggn/J
021012   B6(D2)-Tg(CAG-Brainbow1.0)3Eggn/J
021469   B6(D2)-Tg(CAG-GFP,-Uprt)985Cdoe/J
016958   B6.129(Cg)-Foxp3tm3(DTR/GFP)Ayr/J
007676   B6.129(Cg)-Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/J
004178   B6.129(Cg)-Tg(CAG-Bgeo/GFP)21Lbe/J
018979   B6.129(Cg)-Tg(CAG-EGFP)D4Nagy/KnwJ
010635   B6.129(FVB)-Alcamtm1Jawe/J
006071   B6.129-Gt(ROSA)26Sortm1(CAG-EGFP)Luo/J
008606   B6.129-Gt(ROSA)26Sortm1Joe/J
006080   B6.129-Gt(ROSA)26Sortm2(CAG-Dsred2/EGFP)Luo/J
006075   B6.129-Gt(ROSA)26Sortm3(CAG-EGFP/Dsred2)Luo/J
011036   B6.129-Hoxa11tm1Dmwe/J
008451   B6.129P(Cg)-Ptprca Cx3cr1tm1Litt/LittJ
005582   B6.129P-Cx3cr1tm1Litt/J
008710   B6.129P2(129S4)-Hprttm10(Ple162-EGFP/cre)Ems/Mmjax
008877   B6.129P2(129S4)-Hprttm12(Ple177-EGFP/cre)Ems/Mmjax
009114   B6.129P2(129S4)-Hprttm14(Ple103-EGFP/cre)Ems/Mmjax
008709   B6.129P2(129S4)-Hprttm9(Ple178-EGFP/cre)Ems/Mmjax
009113   B6.129P2(Cg)-Hprttm13(Ple54-EGFP)Ems/Mmjax
009115   B6.129P2(Cg)-Hprttm15(Ple111-EGFP)Ems/Mmjax
009118   B6.129P2(Cg)-Hprttm18(Ple90-EGFP)Ems/Mmjax
009353   B6.129P2(Cg)-Hprttm20(Ple53-EGFP)Ems/Mmjax
009596   B6.129P2(Cg)-Hprttm33(Ple183-EGFP)Ems/Mmjax
010770   B6.129P2(Cg)-Hprttm34(Ple186-EGFP)Ems/Mmjax
008706   B6.129P2(Cg)-Hprttm4(Ple88-EGFP)Ems/Mmjax
010789   B6.129P2(Cg)-Hprttm54(Ple233-EGFP)Ems/Mmjax
008707   B6.129P2(Cg)-Hprttm7(Ple185-EGFP)Ems/Mmjax
008708   B6.129P2(Cg)-Hprttm8(Ple151-EGFP)Ems/Mmjax
007766   B6.129P2(Cg)-Olfr160tm6Mom/MomJ
007572   B6.129P2(Cg)-Rorctm2Litt/J
005693   B6.129P2-Cxcr6tm1Litt/J
008875   B6.129P2-Lgr5tm1(cre/ERT2)Cle/J
016934   B6.129P2-Lgr6tm2.1(cre/ERT2)Cle/J
021794   B6.129S1(Cg)-Ascl3tm1.1(EGFP/cre)Ovi/J
009380   B6.129S1-Irf4tm1Rdf/J
021930   B6.129S1-Tg(CAG-EGFP)S1C2Tpo/KnwPeaJ
022510   B6.129S4-Gpr88tm1.1(cre/GFP)Rpa/J
007669   B6.129S4-Pdgfratm11(EGFP)Sor/J
013061   B6.129S6-Ccr6tm1(EGFP)Irw/J
008379   B6.129S6-Il10tm1Flv/J
012644   B6.129S7-Pcdhgtm2Xzw/J
008466   B6.129X1(Cg)-Shhtm6Amc/J
009081   B6.129X1-Id1tm1Xhsu/J
006772   B6.Cg-Foxp3tm2Tch/J
005670   B6.Cg-Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/J
007906   B6.Cg-Gt(ROSA)26Sortm6(CAG-ZsGreen1)Hze/J
005491   B6.Cg-Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
022486   B6.Cg-Ptprca Tg(UBC-PA-GFP)1Mnz/J
013115   B6.Cg-Rag1tm1Mom Tg(UBC-GFP)30Scha/J
005622   B6.Cg-Shhtm1(EGFP/cre)Cjt/J
007484   B6.Cg-Tyrc-2J Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
008705   B6.Cg-Tg(CAG-DsRed,-EGFP)5Gae/J
007575   B6.Cg-Tg(CAG-Ngb,-EGFP)1Dgrn/J
008111   B6.Cg-Tg(CAG-Ub*G76V/GFP)1Dant/J
008112   B6.Cg-Tg(CAG-Ub*G76V/GFP)2Dant/J
022148   B6.Cg-Tg(CSNK1D*,-EGFP)827Yfu/J
022149   B6.Cg-Tg(CSNK1D,-EGFP)432Yfu/J
023404   B6.Cg-Tg(CSNK1D,-EGFP)433Yfu/J
022787   B6.Cg-Tg(Chst4-EGFP)23Nrud/J
013134   B6.Cg-Tg(Col1a1*2.3-GFP)1Rowe/J
017466   B6.Cg-Tg(Col1a1*3.6-Topaz)2Rowe/J
018306   B6.Cg-Tg(Fos-tTA,Fos-EGFP*)1Mmay/J
014135   B6.Cg-Tg(Fos/EGFP)1-3Brth/J
007673   B6.Cg-Tg(Gad1-EGFP)3Gfng/J
010835   B6.Cg-Tg(Gfap-EGFP)3739Sart/J
007897   B6.Cg-Tg(Gt(ROSA)26Sor-EGFP)I1Able/J
006069   B6.Cg-Tg(HIST1H2BB/EGFP)1Pa/J
005029   B6.Cg-Tg(Hlxb9-GFP)1Tmj/J
024808   B6.Cg-Tg(Inpp5d-EGFP)DLrr/CprJ
006864   B6.Cg-Tg(Ins1-EGFP)1Hara/J
005244   B6.Cg-Tg(Krt1-15-EGFP)2Cot/J
012643   B6.Cg-Tg(Ly6a-EGFP)G5Dzk/J
008323   B6.Cg-Tg(Mc4r-MAPT/Sapphire)21Rck/J
007742   B6.Cg-Tg(Myh11-cre,-EGFP)2Mik/J
008321   B6.Cg-Tg(Npy-MAPT/Sapphire)1Rck/J
021232   B6.Cg-Tg(Nrl-EGFP)1Asw/J
008324   B6.Cg-Tg(Pmch-MAPT/CFP)1Rck/J
008322   B6.Cg-Tg(Pomc-MAPT/Topaz)1Rck/J
007902   B6.Cg-Tg(RP23-268L19-EGFP)2Mik/J
022086   B6.Cg-Tg(RP24-131B16/EGFP)13Ghan/J
019494   B6.Cg-Tg(RP24-131B16/EGFP)37Ghan/J
007894   B6.Cg-Tg(Rgs4-EGFP)4Lvt/J
021614   B6.Cg-Tg(S100A8-cre,-EGFP)1Ilw/J
012893   B6.Cg-Tg(S100a4-EGFP)M1Egn/YunkJ
006361   B6.Cg-Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/J
016998   B6.Cg-Tg(TetO-Axin1,EGFP)TA6Cos/J
007921   B6.Cg-Tg(Thy1-Brainbow2.1)RLich/J
007919   B6.Cg-Tg(Thy1-EGFP)OJrs/GfngJ
021069   B6.Cg-Tg(Thy1-PA-GFP)5Rmpl/J
021070   B6.Cg-Tg(Thy1-PA-GFP)6Rmpl/J
015805   B6.Cg-Tg(UBC-GFP,-TVA)1Clc/J
015806   B6.Cg-Tg(UBC-GFP,-TVA)2Clc/J
015807   B6.Cg-Tg(UBC-GFP,-TVA)3Clc/J
024688   B6.FVB(129S)-Tg(Pax6-GFP/cre)1Rilm/J
008226   B6.FVB-Tg(CAG-EGFP,-ALPP)2.6Ggc/J
018056   B6.FVB-Tg(CAG-boNT/B,-EGFP)U75-56Fwp/J
018055   B6.FVB-Tg(H2-K-S100a9,GFP)1Gabr/J
006000   B6.FVB-Tg(ITGAM-DTR/EGFP)34Lan/J
006417   B6.FVB-Tg(Npy-hrGFP)1Lowl/J
024033   B6.FVB-Tg(Shank3-EGFP)1Hzo/J
005738   B6.FVB-Tg(tetO-EGFP,-Tgfbr2)8Mcle/J
008126   B6.NOD-Tg(Cd4-EGFP)1Lt/J
023161   B6129S-Tg(Foxp3-EGFP/cre)1aJbs/J
008516   B6;129-Gt(ROSA)26Sortm1Joe/J
004077   B6;129-Gt(ROSA)26Sortm2Sho/J
009600   B6;129-Six2tm3(EGFP/cre/ERT2)Amc/J
008678   B6;129-Ubbtm1Rrk/J
010988   B6;129P-Cyp11a1tm1(GFP/cre)Pzg/J
010985   B6;129P-Klf3tm1(cre/ERT2)Pzg/J
015854   B6;129P2-Foxl2tm1(GFP/cre/ERT2)Pzg/J
008769   B6;129P2-Gpr15tm1.1Litt/J
012601   B6;129P2-Lyve1tm1.1(EGFP/cre)Cys/J
021162   B6;129P2-Mapttm2Arbr/J
006717   B6;129P2-Olfr124tm1Mom/MomJ
006665   B6;129P2-Olfr151tm13(rI7)Mom/MomJ
006666   B6;129P2-Olfr151tm24(Olfr2)Mom/MomJ
006676   B6;129P2-Olfr151tm26Mom/MomJ
006734   B6;129P2-Olfr151tm35(Adrb2)Mom/MomJ
006714   B6;129P2-Olfr160tm11(Olfr545)Mom/MomJ
006649   B6;129P2-Olfr17tm5(Olfr6)Mom/MomJ
006712   B6;129P2-Olfr545tm1Mom/MomJ
006715   B6;129P2-Olfr545tm3(Olfr160)Mom/MomJ
004946   B6;129P2-Omptm2(spH)Mom/J
006667   B6;129P2-Omptm3Mom/MomJ
006728   B6;129P2-Vmn2r26tm2Mom/MomJ
012735   B6;129S-Gt(ROSA)26Sortm35.1(CAG-aop3/GFP)Hze/J
010987   B6;129S-Sox18tm1(GFP/cre/ERT2)Pzg/J
017592   B6;129S-Sox2tm2Hoch/J
004858   B6;129S1-Tshrtm1Rmar/J
007843   B6;129S4-Efnb2tm2Sor/J
012463   B6;129S4-Foxd1tm1(GFP/cre)Amc/J
012464   B6;129S4-Foxd1tm2(GFP/cre/ERT2)Amc/J
016836   B6;129S4-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm7(tetO-HIST1H2BJ/GFP)Jae/J
008214   B6;129S4-Pou5f1tm2Jae/J
008078   B6;129S4-Tcf3tm5Zhu/J
017495   B6;129S7-Crim1tm1(GFP/cre/ERT2)Pzg/J
012436   B6;129S7-Tg(CAG-lacZ,-BMPR1A*,-EGFP)1Mis/Mmjax
008605   B6;C3-Tg(CAG-DsRed,-EGFP)5Gae/J
008080   B6;C3-Tg(CAG-SAC/EGFP)35Rang/J
010827   B6;C3-Tg(FOXJ1-EGFP)85Leo/J
010930   B6;CB-Tg(Pbsn-Hpn,-GFP)DVv/J
010704   B6;CBA-Tg(ATP6V1B1-EGFP)1Rnel/Mmjax
004966   B6;CBA-Tg(Acrv1-EGFP)2727Redd/J
021588   B6;CBA-Tg(Gast-EGFP)1Tcw/J
007986   B6;CBA-Tg(H*/Olfr16-GFP)11Mom/MomJ
007987   B6;CBA-Tg(H*/Olfr16-GFP)25Mom/MomJ
007979   B6;CBA-Tg(H/Olfr16-GFP)3Mom/MomJ
007980   B6;CBA-Tg(H/Olfr16-GFP)4Mom/MomJ
007981   B6;CBA-Tg(H/Olfr16-GFP)6Mom/MomJ
007984   B6;CBA-Tg(H/Olfr16-taumCherry,-tauGFP)11Mom/MomJ
007985   B6;CBA-Tg(H/Olfr16-taumCherry,-tauGFP)13Mom/MomJ
007982   B6;CBA-Tg(H/Olfr16-taumRFP,-tauGFP)8Mom/MomJ
007983   B6;CBA-Tg(H/Olfr16-taumRFP,-tauGFP)9Mom/MomJ
007978   B6;CBA-Tg(Hf/Olfr16-GFP)47Mom/MomJ
007977   B6;CBA-Tg(Hf/Olfr16-GFP)7Mom/MomJ
004654   B6;CBA-Tg(Pou5f1-EGFP)2Mnn/J
011070   B6;CBA-Tg(Thy1-EGFP)SJrs/NdivJ
014651   B6;CBA-Tg(Thy1-spH)21Vnmu/J
015814   B6;CBA-Tg(Thy1-spH)64Vnmu/FrkJ
017494   B6;D-Tg(Tshz3-GFP/cre)43Amc/J
025122   B6;D2-Tg(RP24-330G11-EGFP)1Mik/J
005621   B6;D2-Tg(S100B-EGFP)1Wjt/J
008344   B6;DBA-Tg(Fos-tTA,Fos-EGFP*)1Mmay Tg(tetO-lacZ,tTA*)1Mmay/J
014160   B6;DBA-Tg(S100b-EGFP/cre/ERT2)22Amc/J
014159   B6;DBA-Tg(Tmem100-EGFP/cre/ERT2)30Amc/J
015855   B6;DBA-Tg(Upk3a-GFP/cre/ERT2)26Amc/J
009159   B6;FVB-Tg(Cnp-EGFP/Rpl10a)JD368Htz/J
021187   B6;FVB-Tg(Pbsn-rtTA*M2)42Xy/J
004690   B6;FVB-Tg(Pcp2-EGFP)2Yuza/J
006147   B6;FVB-Tg(Sfpi1,-EGFP)7Dgt/J
019381   B6;FVB-Tg(Zfp423-EGFP)7Brsp/J
021022   B6;SJL-Tg(AMELX-EGFP/RHOA*T19N)13Gibs/Mmjax
006043   B6;SJL-Tg(Oxt/EGFP)AI03Wsy/J
021078   B6N.129S1-Mrgprb4tm4.1(flpo)And/J
019013   B6N.129S6(Cg)-Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
018974   B6N.B6-Tg(Nr4a1-EGFP/cre)820Khog/J
018549   B6N.Cg-Tg(Csf1r-EGFP)1Hume/J
020650   B6N.Cg-Tg(Trpm8-EGFP)1Dmck/J
018913   B6N.Cg-Tg(tetO-GFP,-lacZ)G3Rsp/J
007732   B6SJL-Tg(Dazl-hrGFP)4Gar/J
004190   C.129-Il4tm1Lky/J
005700   C.129P2-Cxcr6tm1Litt/J
011010   C.B6-Tg(Foxp3-DTR/EGFP)23.2Spar/Mmjax
006769   C.Cg-Foxp3tm2Tch/J
010545   C.FVB-Tg(CAG-luc,-GFP)L2G85Chco/FathJ
008591   C57BL/6-Ackr3tm1Litt/J
023520   C57BL/6-Bcrtm1(BCR/ABL)Tsr/J
012343   C57BL/6-Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky/J
012361   C57BL/6-Gt(ROSA)26Sortm9(Rac1*,EGFP)Rsky/J
010724   C57BL/6-Trim21tm1Hm/J
017469   C57BL/6-Tg(BGLAP-Topaz)1Rowe/J
006567   C57BL/6-Tg(CAG-EGFP)131Osb/LeySopJ
003291   C57BL/6-Tg(CAG-EGFP)1Osb/J
005070   C57BL/6-Tg(Csf1r-EGFP-NGFR/FKBP1A/TNFRSF6)2Bck/J
017467   C57BL/6-Tg(Dmp1-Topaz)1Ikal/J
011003   C57BL/6-Tg(Foxp3-DTR/EGFP)23.2Spar/Mmjax
023800   C57BL/6-Tg(Foxp3-GFP)90Pkraj/J
012943   C57BL/6-Tg(Ins2-luc/EGFP/TK)300Kauf/J
016617   C57BL/6-Tg(Nr4a1-EGFP/cre)820Khog/J
012890   C57BL/6-Tg(Scgb1a1-Il17f,GFP)1Cdon/J
007265   C57BL/6-Tg(Sry-EGFP)92Ei Chr YAKR/J/EiJ
007264   C57BL/6-Tg(Sry-EGFP)92Ei Tg(Sry)4Ei Chr YPOS/EiJ
004353   C57BL/6-Tg(UBC-GFP)30Scha/J
022476   C57BL/6-Tg(Uchl1-EGFP)G1Phoz/J
005706   C57BL/6-Tg(tetO-CDK5R1/GFP)337Lht/J
007567   C57BL/6J-Tg(Itgax-cre,-EGFP)4097Ach/J
018895   C57BL/6J-Tg(Krt6,-cre,-Cerulean)1Grsr/Grsr
018896   C57BL/6J-Tg(Krt6,-cre,-Cerulean)2Grsr/Grsr
018898   C57BL/6J-Tg(Krt6,-cre,-Cerulean)4Grsr/Grsr
018899   C57BL/6J-Tg(Krt6,-cre,-Cerulean)5Grsr/Grsr
009593   C57BL/6J-Tg(Pomc-EGFP)1Low/J
003927   C57BL/6J-Tg(Sry-EGFP)92Ei/EiJ
019363   C57BL/6J-Tg(Trp63,-cre,-Cerulean)10Grsr/Grsr
018792   C57BL/6J-Tg(Trp63,-cre,-Cerulean)4Grsr/GrsrJ
018151   C57BL/6N-Krt17tm1(cre,Cerulean)Murr/GrsrJ
024753   C57BL/6N-Tg(Ddx25*-EGFP)1Mld/J
024752   C57BL/6N-Tg(Ddx25-EGFP)1Mld/J
008234   CB6-Tg(CAG-EGFP/CETN2)3-4Jgg/J
007677   CB6-Tg(Gad1-EGFP)G42Zjh/J
007898   CBy.Cg-Tg(Gt(ROSA)26Sor-EGFP)I1Able/J
007075   CByJ.B6-Tg(CAG-EGFP)1Osb/J
007076   CByJ.B6-Tg(UBC-GFP)30Scha/J
010548   D1.FVB(Cg)-Tg(CAG-luc,-GFP)L2G85Chco/FathJ
008450   FVB-Tg(CAG-luc,-GFP)L2G85Chco/J
003718   FVB-Tg(GadGFP)45704Swn/J
010947   FVB-Tg(Gstm5-EGFP)1Ilis/J
005515   FVB-Tg(ITGAM-DTR/EGFP)34Lan/J
017484   FVB-Tg(JPH3-GFP,-JPH3*)GXwy/J
006421   FVB-Tg(Pomc1-hrGFP)1Lowl/J
005688   FVB-Tg(Rag2-EGFP)1Mnz/J
024636   FVB.B6-Tg(CAG-cat,-EGFP)1Rbns/KrnzJ
012429   FVB.Cg-Gt(ROSA)26Sortm1(CAG-lacZ,-EGFP)Glh/J
003516   FVB.Cg-Tg(CAG-EGFP)B5Nagy/J
022735   FVB.Cg-Tg(Cspg4-EGFP*)HDbe/J
016573   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(S100B-EGFP)1Wjt Tg(SMN2*delta7)4299Ahmb/J
007483   FVB.Cg-Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
008200   FVB/N-Tg(CAG-EGFP,-ALPP)2.6Ggc/J
018393   FVB/N-Tg(CAG-EGFP,TGFB1*)C8Kul/J
009354   FVB/N-Tg(Dazl-EGFP)10Rarp/J
018548   FVB/N-Tg(GFAP-Cadm1/EGFP)42Oje/J
003257   FVB/N-Tg(GFAPGFP)14Mes/J
025097   NOD.129X1(Cg)-Foxp3tm2Tch/DvsJ
013116   NOD.B6-Tg(Ins2-luc/EGFP/TK)300Kauf/J
013233   NOD.B6-Tg(Itgax-cre,-EGFP)4097Ach/J
006698   NOD.Cg-Il4tm1Lky/JbsJ
021937   NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(CAG-EGFP)1Osb/SzJ
017619   NOD.Cg-Prkdcscid Tg(CAG-EGFP)1Osb/KupwJ
008173   NOD.Cg-Tg(Ins1-EGFP)1Hara/QtngJ
005076   NOD.Cg-Tg(tetO-EGFP/FADD)1Doi/DoiJ
010542   NOD.FVB-Tg(CAG-luc,-GFP)L2G85Chco/FathJ
008547   NOD.FVB-Tg(ITGAM-DTR/EGFP)34Lan/JdkJ
005082   NOD/ShiLt-Tg(ACTB-Ica1/EGFP)18Mdos/MdosJ
005334   NOD/ShiLt-Tg(Cd4-EGFP)1Lt/J
008694   NOD/ShiLt-Tg(Foxp3-EGFP/cre)1cJbs/J
005282   NOD/ShiLtJ-Tg(Ins1-EGFP/GH1)14Hara/HaraJ
012881   STOCK Ascl1tm1Reed/J
008666   STOCK Fmn1tm1Made/J
016961   STOCK Foxp3tm9(EGFP/cre/ERT2)Ayr/J
006331   STOCK Gt(ROSA)26Sortm1(DTA)Jpmb/J
005572   STOCK Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/J
017596   STOCK Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb Tg(tetO-SMN2,-luc)#aAhmb/J
017597   STOCK Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb Tg(tetO-SMN2,-luc)#bAhmb/J
018903   STOCK Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
007576   STOCK Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/J
008876   STOCK Hprttm11(Ple176-EGFP/cre)Ems/Mmjax
009349   STOCK Hprttm31(Ple67-EGFP)Ems/Mmjax
009594   STOCK Hprttm32(Ple112-EGFP)Ems/Mmjax
017530   STOCK Igs2tm2(ACTB-tdTomato,-EGFP)Luo Trp53tm1Tyj Nf1tm1Par/J
013749   STOCK Iis2tm1(ACTB-EGFP,-tdTomato)Luo/J
013751   STOCK Iis2tm2(ACTB-tdTomato,-EGFP)Luo/J
017932   STOCK Iis3tm1.1(ACTB-EGFP*)Luo/J
017923   STOCK Iis3tm2.1(ACTB-EGFP*,-tdTomato)Luo/J
017701   STOCK Kiss1tm1.1(cre/EGFP)Stei/J
004808   STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
004779   STOCK Mapttm1(EGFP)Klt/J
005692   STOCK Nphs1tm1Rkl/J
006702   STOCK Ntstm1Mom/MomJ
006622   STOCK Olfr151tm10Mom/MomJ
006646   STOCK Olfr151tm11(Olfr160)Mom/MomJ
006692   STOCK Olfr151tm16(Olfr160/Olfr161)Mom/MomJ
006627   STOCK Olfr151tm4Mom/MomJ
006626   STOCK Olfr151tm6Mom/MomJ
006625   STOCK Olfr151tm7Mom/MomJ
006624   STOCK Olfr151tm8Mom/MomJ
006623   STOCK Olfr151tm9Mom/MomJ
006740   STOCK Olfr160tm1(Olfr151)Mom Tg(Olfr151,taulacZ)AMom/MomJ
006741   STOCK Olfr160tm1(Olfr151)Mom Tg(Olfr151,taulacZ)BMom/MomJ
006647   STOCK Olfr160tm1(Olfr151)Mom/MomJ
006636   STOCK Olfr160tm5(Cnga2)Mom/MomJ
006678   STOCK Olfr160tm6Mom/MomJ
006650   STOCK Olfr17tm6(Olfr713)Mom/MomJ
006669   STOCK Olfr17tm7Mom/MomJ
009061   STOCK Osr1tm1(EGFP/cre/ERT2)Amc/J
022757   STOCK Prg4tm1(GFP/cre/ERT2)Abl/J
006770   STOCK Rag1tm1Mom Tg(TIE2GFP)287Sato/J
006633   STOCK Vmn1r49tm3Mom/MomJ
010911   STOCK Wt1tm1(EGFP/cre)Wtp/J
017472   STOCK Tg(Acp5-CFP,Ibsp-YFP,Dmp1-RFP)1Pmay/J
006850   STOCK Tg(CAG-Bgeo,-NOTCH1,-EGFP)1Lbe/J
006876   STOCK Tg(CAG-Bgeo,-TEL/AML1,-EGFP)A6Lbe/J
003920   STOCK Tg(CAG-Bgeo/GFP)21Lbe/J
003115   STOCK Tg(CAG-EGFP)B5Nagy/J
003116   STOCK Tg(CAG-EGFP)D4Nagy/J
017919   STOCK Tg(CAG-EGFP,-dsRed2/RNAi:Tardbp)6Zxu/J
011106   STOCK Tg(CAG-GFP*)1Hadj/J
013753   STOCK Tg(CAG-KikGR)33Hadj/J
013754   STOCK Tg(CAG-KikGR)75Hadj/J
019082   STOCK Tg(CMV-GFP,-BBS4)4T25Vcs/J
005105   STOCK Tg(Chx10-EGFP/cre,-ALPP)2Clc/J
017468   STOCK Tg(Col1a1*3.6-Cyan)2Rowe/J
018322   STOCK Tg(Cp-EGFP)25Gaia/ReyaJ
006334   STOCK Tg(Gad1-EGFP)94Agmo/J
006340   STOCK Tg(Gad1-EGFP)98Agmo/J
007896   STOCK Tg(Gt(ROSA)26Sor-EGFP)I1Able/J
017952   STOCK Tg(Isl1-EGFP*)1Slp/J
012477   STOCK Tg(Myh6*/tetO-GCaMP2)1Mik/J
008579   STOCK Tg(PSCA-EGFP)1Witt/J
024578   STOCK Tg(Pax6-GFP/cre)1Rilm/J
023345   STOCK Tg(Pgk1-Ccnb1/EGFP)1Aklo/J
012276   STOCK Tg(Piwil2/EGFP)1Ghan/J
012277   STOCK Tg(Piwil4/EGFP)1Ghan/J
012452   STOCK Tg(Rr5-GFP/cre)1Sapc/J
006570   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(Hlxb9-GFP)1Tmj/J
009606   STOCK Tg(Six2-EGFP/cre)1Amc/J
018148   STOCK Tg(Slc17a8-EGFP)1Edw/SealJ
013752   STOCK Tg(TCF/Lef1-HIST1H2BB/EGFP)61Hadj/J
003658   STOCK Tg(TIE2GFP)287Sato/J
021226   STOCK Tg(Thy1-Brainbow3.1)18Jrs/J
021225   STOCK Tg(Thy1-Brainbow3.1)3Jrs/J
021227   STOCK Tg(Thy1-Brainbow3.2)7Jrs/J
007788   STOCK Tg(Thy1-EGFP)MJrs/J
016981   STOCK Tg(Uchl1-HIST2H2BE/mCherry/EGFP*)FSout/J
025193   STOCK Tg(Vmn1r232-Mapt/EGFP)1Dlc/J
018281   STOCK Tg(Wnt7a-EGFP/cre)#Bhr/Mmjax
006129   STOCK Tg(Zp3-EGFP)1Dean/J
023724   STOCK Tg(mI56i-cre,EGFP)1Kc/J
017755   STOCK Tg(tetO-GCAMP2)12iRyu/J
005104   STOCK Tg(tetO-HIST1H2BJ/GFP)47Efu/J
005699   STOCK Tg(tetO-Ipf1,EGFP)956.6Macd/J
017918   STOCK Tg(tetO-MAML1*/EGFP)2Akar/J
017906   STOCK Tg(tetO-hop/EGFP,-COP4/mCherry)6Kftnk/J
012345   STOCK Tg(tetO-tdTomato,-Syp/EGFP*)1.1Luo/J
View Strains carrying other alleles of GFP     (352 strains)

View Strains carrying other alleles of Itgax     (9 strains)

View Strains carrying other alleles of DTR     (5 strains)

Additional Web Information

Fluorescent Proteins/lacZ Systems

JAX® NOTES, Fall 2002; 487. Green Fluorescent Protein (GFP) Transgenic Mice Poster Available.

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Tg(Itgax-DTR/EGFP)57Lan/0

        C.FVB-Tg(Itgax-DTR/EGFP)57Lan
  • mortality/aging
  • premature death
    • repeated treatment with diphtheria toxin results in lethality due to dendritic cell depletion   (MGI Ref ID J:93488)
  • immune system phenotype
  • abnormal CD8-positive T cell differentiation
    • adoptive transfer experiments demonstrate that CD8+ T cell priming with cell-associated antigen does not occur in diphtheria-induced dendritic cell depleted mice   (MGI Ref ID J:93488)
  • abnormal T cell activation
    • treatment with diphtheria toxin results in a loss of in vitro stimulation of alloreactive T cells   (MGI Ref ID J:93488)
  • decreased CD8-positive T cell number
    • treatment with diphtheria toxin results in a substantial loss of CD8+ T cells   (MGI Ref ID J:93488)
  • decreased dendritic cell number
    • CD11c+ (Itgax+) dendritic cells are depleted for 2 days following treatment with diphtheria toxin   (MGI Ref ID J:93488)
  • defective cytotoxic T cell cytolysis
    • in adoptive transfer experiments using diphtheria-induced dendritic cell depleted mice infected with Listeria or malaria at the liver stage   (MGI Ref ID J:93488)
  • increased neutrophil cell number
    • neutrophilia is observed in blood after diphtheria toxin treatment, indicating that there is no background effect with respect to C57BL/6   (MGI Ref ID J:194800)
  • hematopoietic system phenotype
  • abnormal CD8-positive T cell differentiation
    • adoptive transfer experiments demonstrate that CD8+ T cell priming with cell-associated antigen does not occur in diphtheria-induced dendritic cell depleted mice   (MGI Ref ID J:93488)
  • abnormal T cell activation
    • treatment with diphtheria toxin results in a loss of in vitro stimulation of alloreactive T cells   (MGI Ref ID J:93488)
  • decreased CD8-positive T cell number
    • treatment with diphtheria toxin results in a substantial loss of CD8+ T cells   (MGI Ref ID J:93488)
  • decreased dendritic cell number
    • CD11c+ (Itgax+) dendritic cells are depleted for 2 days following treatment with diphtheria toxin   (MGI Ref ID J:93488)
  • defective cytotoxic T cell cytolysis
    • in adoptive transfer experiments using diphtheria-induced dendritic cell depleted mice infected with Listeria or malaria at the liver stage   (MGI Ref ID J:93488)
  • increased neutrophil cell number
    • neutrophilia is observed in blood after diphtheria toxin treatment, indicating that there is no background effect with respect to C57BL/6   (MGI Ref ID J:194800)

Tg(Itgax-DTR/EGFP)57Lan/0

        C.FVB-Tg(Itgax-DTR/EGFP)57Lan/J
  • immune system phenotype
  • *normal* immune system phenotype
    • conventional T cell, macrophages, B cell, NK cell, and NK T cell numbers are unaffected by treatment with diphtheria toxin   (MGI Ref ID J:96123)
    • abnormal NK cell physiology
      • following treatment with diphtheria toxin and stimulation with alpha-GalCer, only 2% at 6 hours and 4% at 12 hours post-treatment of liver or spleen NK cells stain positive for IFN-gamma compared to 20% to 23% and 13% to 16%, respectively, of cells from transgenic mice not treated with diphtheria toxin   (MGI Ref ID J:96123)
    • decreased circulating interferon-gamma level
      • following treatment with diphtheria toxin, little IFN-gamma in alpha-GalCer-injected mice and no IFN-gamma in alpha-C-GalCer-injected mice was detected unlike in transgenic mice not treated with diphtheria toxin   (MGI Ref ID J:96123)
    • decreased circulating interleukin-12 level
      • following treatment with diphtheria toxin and stimulation with alpha-GalCer or alpha-C-GalCer, virtually no serum IL-12 was detected unlike in transgenic mice not treated with diphtheria toxin   (MGI Ref ID J:96123)
    • decreased dendritic cell number
      • 24 hours after treatment with diphtheria toxin, spleens and livers are depleted of dendritic cells   (MGI Ref ID J:96123)
    • decreased interferon-gamma secretion
      • following treatment with diphtheria toxin and stimulation with alpha-GalCer, only 2% at 6 hours and 4% at 12 hours post-treatment of liver or spleen NK cells stain positive for IFN-gamma compared to 20% to 23% and 13% to 16%, respectively, of cells from transgenic mice not treated with diphtheria toxin   (MGI Ref ID J:96123)
  • homeostasis/metabolism phenotype
  • decreased circulating interferon-gamma level
    • following treatment with diphtheria toxin, little IFN-gamma in alpha-GalCer-injected mice and no IFN-gamma in alpha-C-GalCer-injected mice was detected unlike in transgenic mice not treated with diphtheria toxin   (MGI Ref ID J:96123)
  • decreased circulating interleukin-12 level
    • following treatment with diphtheria toxin and stimulation with alpha-GalCer or alpha-C-GalCer, virtually no serum IL-12 was detected unlike in transgenic mice not treated with diphtheria toxin   (MGI Ref ID J:96123)
  • hematopoietic system phenotype
  • abnormal NK cell physiology
    • following treatment with diphtheria toxin and stimulation with alpha-GalCer, only 2% at 6 hours and 4% at 12 hours post-treatment of liver or spleen NK cells stain positive for IFN-gamma compared to 20% to 23% and 13% to 16%, respectively, of cells from transgenic mice not treated with diphtheria toxin   (MGI Ref ID J:96123)
  • decreased dendritic cell number
    • 24 hours after treatment with diphtheria toxin, spleens and livers are depleted of dendritic cells   (MGI Ref ID J:96123)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Tg(Itgax-DTR/EGFP)57Lan/0

        B6.FVB-Tg(Itgax-DTR/EGFP)57Lan/J
  • mortality/aging
  • increased sensitivity to induced morbidity/mortality
    • mice exhibit an increase in mortality compared to wild-type mice following diphtheria treatment and cecal ligation puncture (CLP) (100% compared to 45% mortality)   (MGI Ref ID J:113232)
    • however, replacement of dendritic cells with wild-type dendritic cells improves survival (mortality drops from 100% to 65%)   (MGI Ref ID J:113232)
  • immune system phenotype
  • *normal* immune system phenotype
    • depletion of Cd11c+ dendritic cells by treatment with diphtheria toxin does not affect accumulation and localization of Tg(TcraTcrb)1100Mjb CD8+ T cells from a Rag1 null mouse in T cell zones of the lymph node and spleen   (MGI Ref ID J:122114)
    • conventional T cell, macrophages, B cell, NK cell, and NK T cell numbers are unaffected by treatment with diphtheria toxin   (MGI Ref ID J:96123)
    • despite an increase in mortality following diphtheria treatment and cecal ligation puncture, mice do not exhibit an increase in bacteremia or cytokine production   (MGI Ref ID J:113232)
    • abnormal NK T cell physiology
      • following treatment with diphtheria toxin and stimulation with alpha-GalCer, 5% of spleen NK T cells stain positive for IFN-gamma and 8% for IL-4 compared to 32% and 30%, respectively, of similarly treated wild-type NK T cells   (MGI Ref ID J:96123)
      • however, normal levels of IFN-gamma and IL-4 production where observed in liver NK T cells   (MGI Ref ID J:96123)
    • abnormal NK cell physiology
      • following treatment with diphtheria toxin and stimulation with alpha-GalCer, only 2% at 6 hours and 4% at 12 hours post-treatment of liver or spleen NK cells stain positive for IFN-gamma compared to 20% to 23% and 13% to 16%, respectively, of cells from transgenic mice not treated with diphtheria toxin   (MGI Ref ID J:96123)
      • following treatment with diphtheria toxin and stimulation with alpha-C-GalCer, less than 1% at 6 and 0.5% to 1% at 12 hours post-treatment of liver or spleen NK cells stain positive for IFN-gamma compared to 6% to 8% and 12% to 14%, respectively, of cells from transgenic mice not treated with diphtheria toxin   (MGI Ref ID J:96123)
      • impaired natural killer cell mediated cytotoxicity
        • unlike in wild-type mice, NK T cell activation measured by specific cell lysis following infection with Leishmania infantum in diphtheria toxin treated mice does not occur   (MGI Ref ID J:125611)
    • decreased circulating interferon-gamma level
      • following treatment with diphtheria toxin, little IFN-gamma in alpha-GalCer-injected mice and no IFN-gamma in alpha-C-GalCer-injected mice was detected unlike in transgenic mice not treated with diphtheria toxin   (MGI Ref ID J:96123)
    • decreased circulating interleukin-12 level
      • following treatment with diphtheria toxin and stimulation with alpha-GalCer or alpha-C-GalCer, virtually no serum IL-12 was detected unlike in transgenic mice not treated with diphtheria toxin   (MGI Ref ID J:96123)
    • decreased dendritic cell number
      • CD11c+ (Itgax+) dendritic cells in lung parenchyma are depleted following treatment with diphtheria toxin   (MGI Ref ID J:100867)
      • 24 hours after treatment with diphtheria toxin, spleens and livers are depleted of dendritic cells   (MGI Ref ID J:96123)
      • treatment with diphtheria toxin depletes CD11chighMHCIIhigh dendritic cells   (MGI Ref ID J:113232)
    • decreased interferon-gamma secretion
      • following treatment with diphtheria toxin and stimulation with alpha-GalCer, only 2% at 6 hours and 4% at 12 hours post-treatment of liver or spleen NK cells stain positive for IFN-gamma compared to 20% to 23% and 13% to 16%, respectively, of cells from transgenic mice not treated with diphtheria toxin   (MGI Ref ID J:96123)
      • following treatment with diphtheria toxin and stimulation with alpha-GalCer, 5% of spleen NK T cells stain positive for IFN-gamma compared to 32% of similarly treated wild-type NK T cells   (MGI Ref ID J:96123)
      • however, normal levels of production where observed in liver NK T cells   (MGI Ref ID J:96123)
      • following treatment with diphtheria toxin and stimulation with alpha-C-GalCer, less than 1% at 6 and 0.5% to 1% at 12 hours post-treatment of liver or spleen NK cells stain positive for IFN-gamma compared to 6% to 8% and 12% to 14%, respectively, of cells from transgenic mice not treated with diphtheria toxin   (MGI Ref ID J:96123)
    • decreased interleukin-12b secretion
      • unlike in wild-type mice, IL-12p40 production following infection with Leishmania infantum in diphtheria toxin treated mice does not occur   (MGI Ref ID J:125611)
    • decreased interleukin-4 secretion
      • following treatment with diphtheria toxin and stimulation with alpha-GalCer, 8% of spleen NK T cells stain positive for IL-4 compared to 30% of similarly treated wild-type NK T cells however, normal levels of production where observed in liver NK T cells   (MGI Ref ID J:96123)
    • sepsis
      • mice exhibit an increase in mortality compared to wild-type mice following diphtheria treatment and cecal ligation puncture (CLP) (100% compared to 45% mortality)   (MGI Ref ID J:113232)
  • homeostasis/metabolism phenotype
  • decreased circulating interferon-gamma level
    • following treatment with diphtheria toxin, little IFN-gamma in alpha-GalCer-injected mice and no IFN-gamma in alpha-C-GalCer-injected mice was detected unlike in transgenic mice not treated with diphtheria toxin   (MGI Ref ID J:96123)
  • decreased circulating interleukin-12 level
    • following treatment with diphtheria toxin and stimulation with alpha-GalCer or alpha-C-GalCer, virtually no serum IL-12 was detected unlike in transgenic mice not treated with diphtheria toxin   (MGI Ref ID J:96123)
  • hematopoietic system phenotype
  • abnormal NK T cell physiology
    • following treatment with diphtheria toxin and stimulation with alpha-GalCer, 5% of spleen NK T cells stain positive for IFN-gamma and 8% for IL-4 compared to 32% and 30%, respectively, of similarly treated wild-type NK T cells   (MGI Ref ID J:96123)
    • however, normal levels of IFN-gamma and IL-4 production where observed in liver NK T cells   (MGI Ref ID J:96123)
  • abnormal NK cell physiology
    • following treatment with diphtheria toxin and stimulation with alpha-GalCer, only 2% at 6 hours and 4% at 12 hours post-treatment of liver or spleen NK cells stain positive for IFN-gamma compared to 20% to 23% and 13% to 16%, respectively, of cells from transgenic mice not treated with diphtheria toxin   (MGI Ref ID J:96123)
    • following treatment with diphtheria toxin and stimulation with alpha-C-GalCer, less than 1% at 6 and 0.5% to 1% at 12 hours post-treatment of liver or spleen NK cells stain positive for IFN-gamma compared to 6% to 8% and 12% to 14%, respectively, of cells from transgenic mice not treated with diphtheria toxin   (MGI Ref ID J:96123)
    • impaired natural killer cell mediated cytotoxicity
      • unlike in wild-type mice, NK T cell activation measured by specific cell lysis following infection with Leishmania infantum in diphtheria toxin treated mice does not occur   (MGI Ref ID J:125611)
  • decreased dendritic cell number
    • CD11c+ (Itgax+) dendritic cells in lung parenchyma are depleted following treatment with diphtheria toxin   (MGI Ref ID J:100867)
    • 24 hours after treatment with diphtheria toxin, spleens and livers are depleted of dendritic cells   (MGI Ref ID J:96123)
    • treatment with diphtheria toxin depletes CD11chighMHCIIhigh dendritic cells   (MGI Ref ID J:113232)

Tg(Itgax-DTR/EGFP)57Lan/0

        involves: C57BL/6 * FVB/N
  • immune system phenotype
  • abnormal alveolar macrophage morphology
    • CD11b+ Langerhans cells and alveolar macrophage are depleted following intratracheally administration of diphtheria toxin   (MGI Ref ID J:137452)
  • decreased dendritic cell number
    • CD11b+ Langerhans cells and alveolar macrophage are depleted following intratracheally administration of diphtheria toxin   (MGI Ref ID J:137452)
    • mesenteric lymph nodes are partially depleted following intratracheally administration of diphtheria toxin   (MGI Ref ID J:137452)
  • decreased interferon-gamma secretion
    • following administration of diphtheria toxin and CD3 stimulation, IFN-gamma production by CD4 and CD8 T cells from the mesenteric lymph nodes is decreased compared to in similarly treated wild-type mice   (MGI Ref ID J:137452)
  • increased susceptibility to viral infection
    • following intratracheally administration of diphtheria toxin, mice exhibit increased severity of influenza infection, increased weight lose and delayed clearance compared to infected wild-type mice   (MGI Ref ID J:137452)
    • the number of virus-specific cytotoxic T lymphoctes is reduced in mice treated with diphtheria toxin and infected with influenza compared to similarly treated wild-type mcie   (MGI Ref ID J:137452)
  • respiratory system phenotype
  • abnormal alveolar macrophage morphology
    • CD11b+ Langerhans cells and alveolar macrophage are depleted following intratracheally administration of diphtheria toxin   (MGI Ref ID J:137452)
  • hematopoietic system phenotype
  • abnormal alveolar macrophage morphology
    • CD11b+ Langerhans cells and alveolar macrophage are depleted following intratracheally administration of diphtheria toxin   (MGI Ref ID J:137452)
  • decreased dendritic cell number
    • CD11b+ Langerhans cells and alveolar macrophage are depleted following intratracheally administration of diphtheria toxin   (MGI Ref ID J:137452)
    • mesenteric lymph nodes are partially depleted following intratracheally administration of diphtheria toxin   (MGI Ref ID J:137452)

Tg(Itgax-DTR/EGFP)57Lan/0

        involves: FVB/N
  • immune system phenotype
  • abnormal response to infection
    • despite normal monocyte numbers in the blood, LPS-treated mice fail to exhibit an accumulation of CD11c+MHCII+DC-SIGN/CD209+CD14+ cells in the skin lymph nodes unlike wild-type mice   (MGI Ref ID J:189122)
    • decreased susceptibility to bacterial infection
      • mice treated with antibiotic, then diphtheria toxin (DTR) and infected with non-invasive Salmonella exhibit decreased bacterial titers in the mesenteric lymph nodes as compared to DTR-untreated controls   (MGI Ref ID J:210086)
  • decreased interleukin-17 secretion
    • in diphtheria toxin- and IMQ-treated mice   (MGI Ref ID J:193548)
  • decreased leukocyte cell number
    • in the skin of diphtheria toxin- and IMQ-treated mice   (MGI Ref ID J:193548)
    • decreased T cell number
      • decreased alpha-beta T cells in the skin of diphtheria toxin- and IMQ-treated mice   (MGI Ref ID J:193548)
      • decreased gamma-delta T cell number
        • in the skin of diphtheria toxin- and IMQ-treated mice   (MGI Ref ID J:193548)
    • decreased neutrophil cell number
      • in the skin of diphtheria toxin- and IMQ-treated mice   (MGI Ref ID J:193548)
  • hematopoietic system phenotype
  • decreased leukocyte cell number
    • in the skin of diphtheria toxin- and IMQ-treated mice   (MGI Ref ID J:193548)
    • decreased T cell number
      • decreased alpha-beta T cells in the skin of diphtheria toxin- and IMQ-treated mice   (MGI Ref ID J:193548)
      • decreased gamma-delta T cell number
        • in the skin of diphtheria toxin- and IMQ-treated mice   (MGI Ref ID J:193548)
    • decreased neutrophil cell number
      • in the skin of diphtheria toxin- and IMQ-treated mice   (MGI Ref ID J:193548)
  • homeostasis/metabolism phenotype
  • decreased physiological sensitivity to xenobiotic
    • mice treated with diphtheria toxin and IMQ are protected from psoriasis development with decreased ear swelling and numbers of leukocytes, neutrophils and gamma-delta and alpha-beta T cells in the skin compared with wild-type mice   (MGI Ref ID J:193548)

Tg(Itgax-DTR/EGFP)57Lan/0

        B6.FVB-Tg(Itgax-DTR/EGFP)57Lan
  • immune system phenotype
  • abnormal circulating cytokine level
    • after DT injection, an increase in Cxcl2 level is observed in serum, but not in Il1, 4, 5 or 7, Tnf, Ccl2, 3, or 5 levels   (MGI Ref ID J:194800)
  • altered susceptibility to infection
    • at 30 hours after dendritic cell depletion in kidney by DT injection and infection with uropathogenic E. coli, numbers of polymorphonuclear neutrophils in kidneys are elevated and a 5-fold decrease in colony forming units of UPEC is observed compared to nondepleted control animals   (MGI Ref ID J:194800)
    • increased susceptibility to bacterial infection
      • with diphtheria toxin at time of induction of pyelonephritis by transurethral infection by UPEC, animals show impaired bacterial clearance   (MGI Ref ID J:194800)
  • decreased dendritic cell number
    • with injection of diphtheria toxin (DT) when transurethral instillation of uropathogenic E. coli (UPEC) is performed to produce a model of pyelonephritis, kidney dendritic cell numbers are reduced by 50% by 6 hours after DT treatment; 30 hours after DT-induced dendritic cell depletion, dendritic cell numbers are decreased by more than 90% in kidney   (MGI Ref ID J:194800)
    • the remaining dendritic cells are not functional, as they do not produce chemokines to attract polymorphonuclear neutrophils   (MGI Ref ID J:194800)
  • decreased neutrophil cell number
    • at 24 hours after diphtheria toxin injection, numbers of PMNs are significantly decreased in bone marrow compared to controls   (MGI Ref ID J:194800)
  • impaired neutrophil recruitment
    • with diphtheria toxin injection at time of induction of pyelonephritis by transurethral infection by UPEC, polymorphonuclear neutrophil (PMN) recruitment is decreased   (MGI Ref ID J:194800)
  • increased monocyte cell number
    • blood monocyte numbers are 2-3 fold greater than control values at 72 hours after DT injection; intrarenal macrophage numbers are increased, peaking at 72 hours after DT   (MGI Ref ID J:194800)
  • increased neutrophil cell number
    • 6 hours after diphtheria toxin injection to induce dendritic cell depletion in noninfected mice, slightly increased polymorphonuclear neutrophil (PMN) cell numbers are detected in the blood, with a 2-fold increase after 24 hours, and peaking at a 5-fold increase at 72 hours after DT treatment; higher intrarenal PMN numbers are seen at 24 and 72 hour   (MGI Ref ID J:194800)
  • hematopoietic system phenotype
  • decreased dendritic cell number
    • with injection of diphtheria toxin (DT) when transurethral instillation of uropathogenic E. coli (UPEC) is performed to produce a model of pyelonephritis, kidney dendritic cell numbers are reduced by 50% by 6 hours after DT treatment; 30 hours after DT-induced dendritic cell depletion, dendritic cell numbers are decreased by more than 90% in kidney   (MGI Ref ID J:194800)
    • the remaining dendritic cells are not functional, as they do not produce chemokines to attract polymorphonuclear neutrophils   (MGI Ref ID J:194800)
  • decreased neutrophil cell number
    • at 24 hours after diphtheria toxin injection, numbers of PMNs are significantly decreased in bone marrow compared to controls   (MGI Ref ID J:194800)
  • impaired neutrophil recruitment
    • with diphtheria toxin injection at time of induction of pyelonephritis by transurethral infection by UPEC, polymorphonuclear neutrophil (PMN) recruitment is decreased   (MGI Ref ID J:194800)
  • increased monocyte cell number
    • blood monocyte numbers are 2-3 fold greater than control values at 72 hours after DT injection; intrarenal macrophage numbers are increased, peaking at 72 hours after DT   (MGI Ref ID J:194800)
  • increased neutrophil cell number
    • 6 hours after diphtheria toxin injection to induce dendritic cell depletion in noninfected mice, slightly increased polymorphonuclear neutrophil (PMN) cell numbers are detected in the blood, with a 2-fold increase after 24 hours, and peaking at a 5-fold increase at 72 hours after DT treatment; higher intrarenal PMN numbers are seen at 24 and 72 hour   (MGI Ref ID J:194800)
  • homeostasis/metabolism phenotype
  • abnormal circulating cytokine level
    • after DT injection, an increase in Cxcl2 level is observed in serum, but not in Il1, 4, 5 or 7, Tnf, Ccl2, 3, or 5 levels   (MGI Ref ID J:194800)
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Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Tg(Itgax-DTR/EGFP)57Lan
Allele Name transgene insertion 57, Richard A Lang
Allele Type Transgenic (Inserted expressed sequence)
Common Name(s) CD11c-DTR; CD11c-DTR-GFP; CD11c-DTR/GFP; CD11c.DTR; CD11c/DTR Tg; CD11cDTR; CD11cDTR tg; DCKO; DTR-GFP; DTR-GRP; Itgax-DTR; Tg(Itgax-DTR/GFP)57Lan; Tg.Itgax-DTR/EGFP.57Lan;
Mutation Made By Steffen Jung,   Weizmann Institute of Science
Strain of OriginFVB/N
Site of ExpressionExpression of the transgene is specific to splenic dendritic cells. All CD8+ and CD8- dentritic cells in the spleen fluoresce and are DT sensititve.
Expressed Gene DTR, Simian Diphtheria Toxin Receptor,
Expressed Gene GFP, Green Fluorescent Protein, jellyfish
Green Fluorescent Protein (GFP), derived from the jellyfish Aequorea victoria, is a versatile reporter molecule which has found use in many biological applications. In some constructs the original molecule has been modified in order to enhance its fluorescence intensity (EGFP, enhanced GFP). When utilized in a transgenic construct, tissue expressing sufficient amounts of GFP will fluoresce when exposed to a 488 nm light source.
Promoter Itgax, integrin alpha X, mouse, laboratory
Molecular Note The transgene contains a fusion product involving simian diphtheria toxin receptor and green fluorescent protein under the control of the mouse Itgax promoter (CD11c). Two lines were created (line 11 and line 57) with 1 to 2 copies and 20 copies of the transgene, respectively. All CD8+ and CD8- dendritic cells in the spleen fluoresce and are DT sensitive. Immunohistochemical and flow cytometric analyses show that expression of the transgene is specific to splenic dendritic cells. [MGI Ref ID J:93488]
 
 
 

Genotyping

Genotyping Information

Genotyping Protocols

Fluorescent Proteins (Generic GFP),

MELT


Fluorescent Proteins (Generic GFP), Standard PCR
Fluorescent Proteins -- Generic GFP, QPCR
TG(DTR/EGFP), Standard PCR
Tg(ITGAM-DTR/EGFP), Melt Curve Analysis


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Jung S; Unutmaz D; Wong P; Sano G; De los Santos K; Sparwasser T; Wu S; Vuthoori S; Ko K; Zavala F; Pamer EG; Littman DR; Lang RA. 2002. In vivo depletion of CD11c(+) dendritic cells abrogates priming of CD8(+) T cells by exogenous cell-associated antigens. Immunity 17(2):211-20. [PubMed: 12196292]  [MGI Ref ID J:93488]

Additional References

Tg(Itgax-DTR/EGFP)57Lan related

Ahmed KA; Wang L; Munegowda MA; Mulligan S; Gordon JR; Griebel P; Xiang J. 2012. Direct in vivo evidence of CD4+ T cell requirement for CTL response and memory via pMHC-I targeting and CD40L signaling. J Leukoc Biol 92(2):289-300. [PubMed: 22544940]  [MGI Ref ID J:186191]

Anzai A; Anzai T; Nagai S; Maekawa Y; Naito K; Kaneko H; Sugano Y; Takahashi T; Abe H; Mochizuki S; Sano M; Yoshikawa T; Okada Y; Koyasu S; Ogawa S; Fukuda K. 2012. Regulatory role of dendritic cells in postinfarction healing and left ventricular remodeling. Circulation 125(10):1234-45. [PubMed: 22308302]  [MGI Ref ID J:196620]

Bajwa A; Huang L; Ye H; Dondeti K; Song S; Rosin DL; Lynch KR; Lobo PI; Li L; Okusa MD. 2012. Dendritic cell sphingosine 1-phosphate receptor-3 regulates Th1-Th2 polarity in kidney ischemia-reperfusion injury. J Immunol 189(5):2584-96. [PubMed: 22855711]  [MGI Ref ID J:189850]

Ballesteros-Tato A; Leon B; Lund FE; Randall TD. 2013. CD4+ T helper cells use CD154-CD40 interactions to counteract T reg cell-mediated suppression of CD8+ T cell responses to influenza. J Exp Med 210(8):1591-601. [PubMed: 23835849]  [MGI Ref ID J:202249]

Bamboat ZM; Ocuin LM; Balachandran VP; Obaid H; Plitas G; Dematteo RP. 2010. Conventional DCs reduce liver ischemia/reperfusion injury in mice via IL-10 secretion. J Clin Invest 120(2):559-69. [PubMed: 20093775]  [MGI Ref ID J:156672]

Bar-On L; Birnberg T; Kim KW; Jung S. 2011. Dendritic cell-restricted CD80/86 deficiency results in peripheral regulatory T-cell reduction but is not associated with lymphocyte hyperactivation. Eur J Immunol 41(2):291-8. [PubMed: 21267999]  [MGI Ref ID J:175433]

Bates JT; Graff AH; Phipps JP; Grayson JM; Mizel SB. 2011. Enhanced Antigen Processing of Flagellin Fusion Proteins Promotes the Antigen-Specific CD8+ T Cell Response Independently of TLR5 and MyD88. J Immunol 186(11):6255-62. [PubMed: 21515787]  [MGI Ref ID J:173205]

Bates JT; Uematsu S; Akira S; Mizel SB. 2009. Direct stimulation of tlr5+/+ CD11c+ cells is necessary for the adjuvant activity of flagellin. J Immunol 182(12):7539-47. [PubMed: 19494277]  [MGI Ref ID J:149297]

Bedenikovic G; Crouse J; Oxenius A. 2014. T-cell help dependence of memory CD8+ T-cell expansion upon vaccinia virus challenge relies on CD40 signaling. Eur J Immunol 44(1):115-26. [PubMed: 24108445]  [MGI Ref ID J:208658]

Behrens EM; Canna SW; Slade K; Rao S; Kreiger PA; Paessler M; Kambayashi T; Koretzky GA. 2011. Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice. J Clin Invest 121(6):2264-77. [PubMed: 21576823]  [MGI Ref ID J:173903]

Ben Baruch-Morgenstern N; Shik D; Moshkovits I; Itan M; Karo-Atar D; Bouffi C; Fulkerson PC; Rashkovan D; Jung S; Rothenberg ME; Munitz A. 2014. Paired immunoglobulin-like receptor A is an intrinsic, self-limiting suppressor of IL-5-induced eosinophil development. Nat Immunol 15(1):36-44. [PubMed: 24212998]  [MGI Ref ID J:208993]

Bessa J; Jegerlehner A; Hinton HJ; Pumpens P; Saudan P; Schneider P; Bachmann MF. 2009. Alveolar macrophages and lung dendritic cells sense RNA and drive mucosal IgA responses. J Immunol 183(6):3788-99. [PubMed: 19710454]  [MGI Ref ID J:152307]

Bianchi T; Pincus LB; Wurbel MA; Rich BE; Kupper TS; Fuhlbrigge RC; Boes M. 2009. Maintenance of peripheral tolerance through controlled tissue homing of antigen-specific T cells in K14-mOVA mice. J Immunol 182(8):4665-74. [PubMed: 19342642]  [MGI Ref ID J:147741]

Birnberg T; Bar-On L; Sapoznikov A; Caton ML; Cervantes-Barragan L; Makia D; Krauthgamer R; Brenner O; Ludewig B; Brockschnieder D; Riethmacher D; Reizis B; Jung S. 2008. Lack of conventional dendritic cells is compatible with normal development and T cell homeostasis, but causes myeloid proliferative syndrome. Immunity 29(6):986-97. [PubMed: 19062318]  [MGI Ref ID J:142682]

Bogunovic M; Ginhoux F; Helft J; Shang L; Hashimoto D; Greter M; Liu K; Jakubzick C; Ingersoll MA; Leboeuf M; Stanley ER; Nussenzweig M; Lira SA; Randolph GJ; Merad M. 2009. Origin of the lamina propria dendritic cell network. Immunity 31(3):513-25. [PubMed: 19733489]  [MGI Ref ID J:152688]

Bouchaud G; Gehrke S; Krieg C; Kolios A; Hafner J; Navarini AA; French LE; Boyman O. 2013. Epidermal IL-15Ralpha acts as an endogenous antagonist of psoriasiform inflammation in mouse and man. J Exp Med 210(10):2105-17. [PubMed: 24019554]  [MGI Ref ID J:204085]

Browne EP; Littman DR. 2009. Myd88 is required for an antibody response to retroviral infection. PLoS Pathog 5(2):e1000298. [PubMed: 19214214]  [MGI Ref ID J:162196]

Bunn PT; Stanley AC; de Labastida Rivera F; Mulherin A; Sheel M; Alexander CE; Faleiro RJ; Amante FH; Montes De Oca M; Best SE; James KR; Kaye PM; Haque A; Engwerda CR. 2014. Tissue requirements for establishing long-term CD4+ T cell-mediated immunity following Leishmania donovani infection. J Immunol 192(8):3709-18. [PubMed: 24634490]  [MGI Ref ID J:210012]

Butovsky O; Kunis G; Koronyo-Hamaoui M; Schwartz M. 2007. Selective ablation of bone marrow-derived dendritic cells increases amyloid plaques in a mouse Alzheimer's disease model. Eur J Neurosci 26(2):413-6. [PubMed: 17623022]  [MGI Ref ID J:127277]

Campbell IK; van Nieuwenhuijze A; Segura E; O'Donnell K; Coghill E; Hommel M; Gerondakis S; Villadangos JA; Wicks IP. 2011. Differentiation of inflammatory dendritic cells is mediated by NF-kappaB1-dependent GM-CSF production in CD4 T cells. J Immunol 186(9):5468-77. [PubMed: 21421852]  [MGI Ref ID J:172752]

Chappell CP; Draves KE; Giltiay NV; Clark EA. 2012. Extrafollicular B cell activation by marginal zone dendritic cells drives T cell-dependent antibody responses. J Exp Med 209(10):1825-40. [PubMed: 22966002]  [MGI Ref ID J:191423]

Chiba S; Baghdadi M; Akiba H; Yoshiyama H; Kinoshita I; Dosaka-Akita H; Fujioka Y; Ohba Y; Gorman JV; Colgan JD; Hirashima M; Uede T; Takaoka A; Yagita H; Jinushi M. 2012. Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1. Nat Immunol 13(9):832-42. [PubMed: 22842346]  [MGI Ref ID J:187594]

Choi DH; Kim KS; Yang SH; Chung DH; Song B; Sprent J; Cho JH; Sung YC. 2011. Dendritic Cell Internalization of alpha-Galactosylceramide from CD8 T Cells Induces Potent Antitumor CD8 T-cell Responses. Cancer Res 71(24):7442-51. [PubMed: 22028323]  [MGI Ref ID J:178846]

Chyou S; Benahmed F; Chen J; Kumar V; Tian S; Lipp M; Lu TT. 2011. Coordinated regulation of lymph node vascular-stromal growth first by CD11c+ cells and then by T and B cells. J Immunol 187(11):5558-67. [PubMed: 22031764]  [MGI Ref ID J:179758]

Ciavarra RP; Stephens A; Nagy S; Sekellick M; Steel C. 2006. Evaluation of immunological paradigms in a virus model: are dendritic cells critical for antiviral immunity and viral clearance? J Immunol 177(1):492-500. [PubMed: 16785546]  [MGI Ref ID J:134380]

Coghill JM; Fowler KA; West ML; Fulton LM; van Deventer H; McKinnon KP; Vincent BG; Lin K; Panoskaltsis-Mortari A; Cook DN; Blazar BR; Serody JS. 2013. CC chemokine receptor 8 potentiates donor Treg survival and is critical for the prevention of murine graft-versus-host disease. Blood 122(5):825-36. [PubMed: 23798714]  [MGI Ref ID J:202274]

Darrasse-Jeze G; Deroubaix S; Mouquet H; Victora GD; Eisenreich T; Yao KH; Masilamani RF; Dustin ML; Rudensky A; Liu K; Nussenzweig MC. 2009. Feedback control of regulatory T cell homeostasis by dendritic cells in vivo. J Exp Med 206(9):1853-62. [PubMed: 19667061]  [MGI Ref ID J:152171]

Denning TL; Wang YC; Patel SR; Williams IR; Pulendran B. 2007. Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses. Nat Immunol 8(10):1086-94. [PubMed: 17873879]  [MGI Ref ID J:125258]

Desai DD; Harbers SO; Flores M; Colonna L; Downie MP; Bergtold A; Jung S; Clynes R. 2007. Fc gamma receptor IIB on dendritic cells enforces peripheral tolerance by inhibiting effector T cell responses. J Immunol 178(10):6217-26. [PubMed: 17475849]  [MGI Ref ID J:146123]

Diao J; Zhao J; Winter E; Cattral MS. 2011. Tumors suppress in situ proliferation of cytotoxic T cells by promoting differentiation of Gr-1(+) conventional dendritic cells through IL-6. J Immunol 186(9):5058-67. [PubMed: 21430223]  [MGI Ref ID J:172866]

Didierlaurent A; Goulding J; Patel S; Snelgrove R; Low L; Bebien M; Lawrence T; van Rijt LS; Lambrecht BN; Sirard JC; Hussell T. 2008. Sustained desensitization to bacterial Toll-like receptor ligands after resolution of respiratory influenza infection. J Exp Med 205(2):323-9. [PubMed: 18227219]  [MGI Ref ID J:131869]

Diehl GE; Longman RS; Zhang JX; Breart B; Galan C; Cuesta A; Schwab SR; Littman DR. 2013. Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX(3)CR1(hi) cells. Nature 494(7435):116-20. [PubMed: 23334413]  [MGI Ref ID J:210086]

Divangahi M; Desjardins D; Nunes-Alves C; Remold HG; Behar SM. 2010. Eicosanoid pathways regulate adaptive immunity to Mycobacterium tuberculosis. Nat Immunol 11(8):751-8. [PubMed: 20622882]  [MGI Ref ID J:162390]

Do JS; Min B. 2009. Differential requirements of MHC and of DCs for endogenous proliferation of different T-cell subsets in vivo. Proc Natl Acad Sci U S A 106(48):20394-8. [PubMed: 19920180]  [MGI Ref ID J:155564]

Dolfi DV; Duttagupta PA; Boesteanu AC; Mueller YM; Oliai CH; Borowski AB; Katsikis PD. 2011. Dendritic cells and CD28 costimulation are required to sustain virus-specific CD8+ T cell responses during the effector phase in vivo. J Immunol 186(8):4599-608. [PubMed: 21389258]  [MGI Ref ID J:172460]

Elhaik-Goldman S; Kafka D; Yossef R; Hadad U; Elkabets M; Vallon-Eberhard A; Hulihel L; Jung S; Ghadially H; Braiman A; Apte RN; Mandelboim O; Dagan R; Mizrachi-Nebenzahl Y; Porgador A. 2011. The Natural Cytotoxicity Receptor 1 Contribution to Early Clearance of Streptococcus pneumoniae and to Natural Killer-Macrophage Cross Talk. PLoS One 6(8):e23472. [PubMed: 21887255]  [MGI Ref ID J:176154]

Engel D; Dobrindt U; Tittel A; Peters P; Maurer J; Gutgemann I; Kaissling B; Kuziel W; Jung S; Kurts C. 2006. Tumor necrosis factor alpha- and inducible nitric oxide synthase-producing dendritic cells are rapidly recruited to the bladder in urinary tract infection but are dispensable for bacterial clearance. Infect Immun 74(11):6100-7. [PubMed: 16966414]  [MGI Ref ID J:113552]

Fei M; Bhatia S; Oriss TB; Yarlagadda M; Khare A; Akira S; Saijo S; Iwakura Y; Fallert Junecko BA; Reinhart TA; Foreman O; Ray P; Kolls J; Ray A. 2011. TNF-{alpha} from inflammatory dendritic cells (DCs) regulates lung IL-17A/IL-5 levels and neutrophilia versus eosinophilia during persistent fungal infection. Proc Natl Acad Sci U S A 108(13):5360-5. [PubMed: 21402950]  [MGI Ref ID J:171233]

Felmy B; Songhet P; Slack EM; Muller AJ; Kremer M; Van Maele L; Cayet D; Heikenwalder M; Sirard JC; Hardt WD. 2013. NADPH oxidase deficient mice develop colitis and bacteremia upon infection with normally avirulent, TTSS-1- and TTSS-2-deficient Salmonella Typhimurium. PLoS One 8(10):e77204. [PubMed: 24143212]  [MGI Ref ID J:209119]

Ferrington DA; Roehrich H; Chang AA; Huang CW; Maldonado M; Bratten W; Rageh AA; Heuss ND; Gregerson DS; Nelson EF; Yuan C. 2013. Corneal wound healing is compromised by immunoproteasome deficiency. PLoS One 8(1):e54347. [PubMed: 23365662]  [MGI Ref ID J:195798]

Fooksman DR; Nussenzweig MC; Dustin ML. 2014. Myeloid cells limit production of antibody-secreting cells after immunization in the lymph node. J Immunol 192(3):1004-12. [PubMed: 24376270]  [MGI Ref ID J:207304]

Frank GM; Buela KA; Maker DM; Harvey SA; Hendricks RL. 2012. Early responding dendritic cells direct the local NK response to control herpes simplex virus 1 infection within the cornea. J Immunol 188(3):1350-9. [PubMed: 22210909]  [MGI Ref ID J:180749]

Freitag N; Tirado-Gonzalez I; Barrientos G; Herse F; Thijssen VL; Weedon-Fekjaer SM; Schulz H; Wallukat G; Klapp BF; Nevers T; Sharma S; Staff AC; Dechend R; Blois SM. 2013. Interfering with Gal-1-mediated angiogenesis contributes to the pathogenesis of preeclampsia. Proc Natl Acad Sci U S A 110(28):11451-6. [PubMed: 23798433]  [MGI Ref ID J:198814]

Fujii S; Goto A; Shimizu K. 2009. Antigen mRNA-transfected, allogeneic fibroblasts loaded with NKT-cell ligand confer antitumor immunity. Blood 113(18):4262-72. [PubMed: 19164596]  [MGI Ref ID J:148431]

Fukuyama T; Kasper LH; Boussouar F; Jeevan T; van Deursen J; Brindle PK. 2009. Histone acetyltransferase CBP is vital to demarcate conventional and innate CD8+ T-cell development. Mol Cell Biol 29(14):3894-904. [PubMed: 19433445]  [MGI Ref ID J:150146]

Fukuyama Y; Tokuhara D; Sekine S; Aso K; Kataoka K; Davydova J; Yamamoto M; Gilbert RS; Tokuhara Y; Fujihashi K; Kunisawa J; Yuki Y; Kiyono H; McGhee JR; Fujihashi K. 2013. Potential roles of CCR5(+) CCR6(+) dendritic cells induced by nasal ovalbumin plus Flt3 ligand expressing adenovirus for mucosal IgA responses. PLoS One 8(4):e60453. [PubMed: 23565250]  [MGI Ref ID J:199945]

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Paveglio SA; Allard J; Foster Hodgkins SR; Ather JL; Bevelander M; Campbell JM; Whittaker LeClair LA; McCarthy SM; van der Vliet A; Suratt BT; Boyson JE; Uematsu S; Akira S; Poynter ME. 2011. Airway epithelial indoleamine 2,3-dioxygenase inhibits CD4+ T cells during Aspergillus fumigatus antigen exposure. Am J Respir Cell Mol Biol 44(1):11-23. [PubMed: 20118221]  [MGI Ref ID J:186825]

Plaks V; Birnberg T; Berkutzki T; Sela S; BenYashar A; Kalchenko V; Mor G; Keshet E; Dekel N; Neeman M; Jung S. 2008. Uterine DCs are crucial for decidua formation during embryo implantation in mice. J Clin Invest 118(12):3954-65. [PubMed: 19033665]  [MGI Ref ID J:144732]

Poeck H; Besch R; Maihoefer C; Renn M; Tormo D; Morskaya SS; Kirschnek S; Gaffal E; Landsberg J; Hellmuth J; Schmidt A; Anz D; Bscheider M; Schwerd T; Berking C; Bourquin C; Kalinke U; Kremmer E; Kato H; Akira S; Meyers R; Hacker G; Neuenhahn M; Busch D;Ruland J; Rothenfusser S; Prinz M; Hornung V; Endres S; Tuting T; Hartmann G. 2008. 5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma. Nat Med 14(11):1256-63. [PubMed: 18978796]  [MGI Ref ID J:143226]

Probst HC; Tschannen K; Odermatt B; Schwendener R; Zinkernagel RM; Van Den Broek M. 2005. Histological analysis of CD11c-DTR/GFP mice after in vivo depletion of dendritic cells. Clin Exp Immunol 141(3):398-404. [PubMed: 16045728]  [MGI Ref ID J:106223]

Probst HC; van den Broek M. 2005. Priming of CTLs by lymphocytic choriomeningitis virus depends on dendritic cells. J Immunol 174(7):3920-4. [PubMed: 15778347]  [MGI Ref ID J:97970]

Qing X; Koo GC; Salmon JE. 2012. Complement regulates conventional DC-mediated NK-cell activation by inducing TGF-beta1 in Gr-1+ myeloid cells. Eur J Immunol 42(7):1723-34. [PubMed: 22535677]  [MGI Ref ID J:187776]

Qiu X; Zhu L; Pollard JW. 2009. Colony-stimulating factor-1-dependent macrophage functions regulate the maternal decidua immune responses against Listeria monocytogenes infections during early gestation in mice. Infect Immun 77(1):85-97. [PubMed: 18852237]  [MGI Ref ID J:144590]

Rahman S; Manuel SL; Khan ZK; Wigdahl B; Acheampong E; Tangy F; Jain P. 2010. Depletion of dendritic cells enhances susceptibility to cell-free infection of human T cell leukemia virus type 1 in CD11c-diphtheria toxin receptor transgenic mice. J Immunol 184(10):5553-61. [PubMed: 20382884]  [MGI Ref ID J:161006]

Rangel-Moreno J; Carragher DM; de la Luz Garcia-Hernandez M; Hwang JY; Kusser K; Hartson L; Kolls JK; Khader SA; Randall TD. 2011. The development of inducible bronchus-associated lymphoid tissue depends on IL-17. Nat Immunol 12(7):639-46. [PubMed: 21666689]  [MGI Ref ID J:174312]

Richert LE; Rynda-Apple A; Harmsen AL; Han S; Wiley JA; Douglas T; Larson K; Morton RV; Harmsen AG. 2014. CD11c(+) cells primed with unrelated antigens facilitate an accelerated immune response to influenza virus in mice. Eur J Immunol 44(2):397-408. [PubMed: 24222381]  [MGI Ref ID J:208992]

Rivera A; Hohl TM; Collins N; Leiner I; Gallegos A; Saijo S; Coward JW; Iwakura Y; Pamer EG. 2011. Dectin-1 diversifies Aspergillus fumigatus-specific T cell responses by inhibiting T helper type 1 CD4 T cell differentiation. J Exp Med 208(2):369-81. [PubMed: 21242294]  [MGI Ref ID J:176853]

Rivollier A; He J; Kole A; Valatas V; Kelsall BL. 2012. Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon. J Exp Med 209(1):139-55. [PubMed: 22231304]  [MGI Ref ID J:181701]

Robb RJ; Lineburg KE; Kuns RD; Wilson YA; Raffelt NC; Olver SD; Varelias A; Alexander KA; Teal BE; Sparwasser T; Hammerling GJ; Markey KA; Koyama M; Clouston AD; Engwerda CR; Hill GR; MacDonald KP. 2012. Identification and expansion of highly suppressive CD8(+)FoxP3(+) regulatory T cells after experimental allogeneic bone marrow transplantation. Blood 119(24):5898-908. [PubMed: 22538855]  [MGI Ref ID J:188644]

Robinson RT; Khader SA; Martino CA; Fountain JJ; Teixeira-Coelho M; Pearl JE; Smiley ST; Winslow GM; Woodland DL; Walter MJ; Conejo-Garcia JR; Gubler U; Cooper AM. 2010. Mycobacterium tuberculosis infection induces il12rb1 splicing to generate a novel IL-12Rbeta1 isoform that enhances DC migration. J Exp Med 207(3):591-605. [PubMed: 20212068]  [MGI Ref ID J:158809]

Ruane D; Brane L; Reis BS; Cheong C; Poles J; Do Y; Zhu H; Velinzon K; Choi JH; Studt N; Mayer L; Lavelle EC; Steinman RM; Mucida D; Mehandru S. 2013. Lung dendritic cells induce migration of protective T cells to the gastrointestinal tract. J Exp Med 210(9):1871-88. [PubMed: 23960190]  [MGI Ref ID J:202859]

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Schindler D; Gutierrez MG; Beineke A; Rauter Y; Rohde M; Foster S; Goldmann O; Medina E. 2012. Dendritic Cells Are Central Coordinators of the Host Immune Response to Staphylococcus aureus Bloodstream Infection. Am J Pathol 181(4):1327-37. [PubMed: 22885107]  [MGI Ref ID J:188587]

Schleicher U; Liese J; Knippertz I; Kurzmann C; Hesse A; Heit A; Fischer JA; Weiss S; Kalinke U; Kunz S; Bogdan C. 2007. NK cell activation in visceral leishmaniasis requires TLR9, myeloid DCs, and IL-12, but is independent of plasmacytoid DCs. J Exp Med 204(4):893-906. [PubMed: 17389237]  [MGI Ref ID J:125611]

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Tortola L; Rosenwald E; Abel B; Blumberg H; Schafer M; Coyle AJ; Renauld JC; Werner S; Kisielow J; Kopf M. 2012. Psoriasiform dermatitis is driven by IL-36-mediated DC-keratinocyte crosstalk. J Clin Invest 122(11):3965-76. [PubMed: 23064362]  [MGI Ref ID J:193548]

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Vallon-Eberhard A; Landsman L; Yogev N; Verrier B; Jung S. 2006. Transepithelial pathogen uptake into the small intestinal lamina propria. J Immunol 176(4):2465-9. [PubMed: 16456006]  [MGI Ref ID J:106225]

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Varol C; Landsman L; Fogg DK; Greenshtein L; Gildor B; Margalit R; Kalchenko V; Geissmann F; Jung S. 2007. Monocytes give rise to mucosal, but not splenic, conventional dendritic cells. J Exp Med 204(1):171-80. [PubMed: 17190836]  [MGI Ref ID J:125312]

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Veiga-Fernandes H; Coles MC; Foster KE; Patel A; Williams A; Natarajan D; Barlow A; Pachnis V; Kioussis D. 2007. Tyrosine kinase receptor RET is a key regulator of Peyer's patch organogenesis. Nature 446(7135):547-51. [PubMed: 17322904]  [MGI Ref ID J:120816]

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Villablanca EJ; Raccosta L; Zhou D; Fontana R; Maggioni D; Negro A; Sanvito F; Ponzoni M; Valentinis B; Bregni M; Prinetti A; Steffensen KR; Sonnino S; Gustafsson JA; Doglioni C; Bordignon C; Traversari C; Russo V. 2010. Tumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses. Nat Med 16(1):98-105. [PubMed: 20037595]  [MGI Ref ID J:155862]

Wakkach A; Mansour A; Dacquin R; Coste E; Jurdic P; Carle GF; Blin-Wakkach C. 2008. Bone marrow microenvironment controls the in vivo differentiation of murine dendritic cells into osteoclasts. Blood 112(13):5074-83. [PubMed: 18768394]  [MGI Ref ID J:143799]

Wallet MA; Sen P; Flores RR; Wang Y; Yi Z; Huang Y; Mathews CE; Earp HS; Matsushima G; Wang B; Tisch R. 2008. MerTK is required for apoptotic cell-induced T cell tolerance. J Exp Med 205(1):219-32. [PubMed: 18195070]  [MGI Ref ID J:131291]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX11

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, this strain is maintained as a hemizygote.
Mating SystemInbred x Hemizygote         (Female x Male)   01-MAR-06
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $232.00Female or MaleHemizygous for Tg(Itgax-DTR/EGFP)57Lan  
Price per Pair (US dollars $)Pair Genotype
$256.00BALB/cJ (000651) x Hemizygous for Tg(Itgax-DTR/EGFP)57Lan  
$253.90Hemizygous for Tg(Itgax-DTR/EGFP)57Lan x BALB/cJ (000651)  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $301.60Female or MaleHemizygous for Tg(Itgax-DTR/EGFP)57Lan  
Price per Pair (US dollars $)Pair Genotype
$332.80BALB/cJ (000651) x Hemizygous for Tg(Itgax-DTR/EGFP)57Lan  
$330.10Hemizygous for Tg(Itgax-DTR/EGFP)57Lan x BALB/cJ (000651)  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

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Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

  Control
   Noncarrier
   000651 BALB/cJ
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

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phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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