Strain Name:

NOD.MRL(C3)-Faslpr/DoiJ

Stock Number:

004519

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Availability:

Cryopreserved - Ready for recovery

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Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names NOD.MRL(C3)-Tnfrsf6lpr/DoiJ    (Changed: 26-JAN-05 )
Type Congenic; Mutant Strain; Spontaneous Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain NOD/ShiLt
Donor Strain MRL
H2 Haplotypeg7
 
Donating Investigator Christophe Benoist,   Joslin Diabetes Center

Appearance
albino
Related Genotype: A/A Tyrc/Tyrc

Description
NOD mice homozygous for the Tnfrsf6 lpr mutation are deficient in Fas antigen expressed on cell surfaces, and the disruption of the Fas-mediated apoptotic pathway results in severe lymphoma in NOD by 4 months of age. This lymphoma is characterized by an expansion of unusual CD4 -, CD8 -, CD3 low , B220 + lymphocytes.
Forty week-old NOD mice homozygous for the Tnfrsf6 lpr mutation are completely protected from spontaneous diabetes and insulitis (as compared to 68% diabetes incidence in the control NOD), even after adoptive transfer of lymphocytes from diabetic NOD mice (0% diabetes incidence 12 weeks post transfer, as compared to NOD controls with 85% incidence 12 weeks post transfer). Recent evidence indicates that Fas-deficient NOD mice are resistant to the adoptive transfer because the abnormal subset of CD4 -, CD8 -, CD3 low , B220 + lymphocytes, which express FasL, destroy the donor T cells via the Fas-FasL apoptotic pathway. When homozygous mutant mice are treated with FasL antibody within the adoptive transfer protocol, diabetes protection is incomplete (60% of female homozygotes developed diabetes vs. 80% in control NODs). (Itoh et. al 1997; Su et. al 2000; Kim et. al 2000)

Development
The Tnfrsf6lpr spontaneous mutation originally arose at the 12th generation of inbreeding of strain MRL/Mp, derived from strains LG, AKR, C3H, and C57BL/6. At the subsequent generation, MRL/Mp lymphoproliferative positive and negative sublines, which had an estimated 89% of their genomes in common, were separated. The mutant gene was then transferred to the MRL negative strain by 5 cycles of cross-intercross matings thus reducing the estimate of residual heterozygosity to 1% from 11% (Stock No. 000485). Additionally, the mutation was transferred to both C57BL/6J (Stock No. 000482) and C3H/HeJ (Stock No. 000480). The Tnfrsf6lpr mutation was then transferred to the NOD inbred strain for 16 generations, after which it was imported into The Jackson Laboratory and brother-sister mating began.

Control Information

  Control
   Wild-type from the colony
   001976 NOD/ShiLtJ
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Faslpr allele
000482   B6.MRL-Faslpr/J
000480   C3.MRL-Faslpr/J
002455   MRL.Cg-B2mtm1Unc Faslpr
022350   MRL.Cg-Nos2tm1Lau Faslpr/J
022760   MRL.Cg-Nos3tm1Unc Faslpr/J
003896   MRL/MpJ Faslpr-Foxq1sa-J/J
006825   MRL/MpJ-Faslpr/2J
000485   MRL/MpJ-Faslpr/J
004922   NOD.MRL-Faslpr/Dvs
View Strains carrying   Faslpr     (9 strains)

Strains carrying other alleles of Fas
003233   B6.129P2-Fastm1Osa/J
007895   C57BL/6-Fastm1Cgn/J
001876   CBA/KlJms-Faslpr-cg/J
003234   MRL.129P2(B6)-Fastm1Osa/J
002983   MRL.CBAJms-Faslpr-cg/J
View Strains carrying other alleles of Fas     (5 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- No similarity to the expected human disease phenotype was found. One or more human genes are associated with this human disease. The mouse genotype may involve mutations to orthologs of one or more of these genes, but the phenotype did not resemble the disease.
Diabetes Mellitus, Insulin-Dependent; IDDM
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Autoimmune Lymphoproliferative Syndrome; ALPS   (FAS)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Faslpr/Faslpr

        NOD.MRL(B6)-Faslpr
  • immune system phenotype
  • decreased susceptibility to autoimmune diabetes
    • during the 24 week period, no animals show diabetes or insulitis (mice are considered diabetic after a blood glucose measure of >300 mg/dl)   (MGI Ref ID J:64051)

Faslpr/Faslpr

        NOD.MRL-Faslpr
  • immune system phenotype
  • decreased susceptibility to autoimmune diabetes
    • when mice are injected with islet specific CD8+ T cell clones, Faslpr mice are resistant to diabetogenic effect of injected T cells; 0/5 of Fas mutants are diabetic within 20 day observation period, while control NOD littermates become diabetic within 6 days   (MGI Ref ID J:78679)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Diabetes and Obesity Research
Type 1 Diabetes (IDDM) Analysis Strains
      NOD Congenics with Mutations Affecting Immunocompetence
      NOD/ShiLtJ Non-MHC Congenics

Faslpr related

Apoptosis Research
Death Receptors

Cancer Research
Genes Regulating Growth and Proliferation

Immunology, Inflammation and Autoimmunity Research
Autoimmunity
      lupus erythematosus
      lupus erythematosus: rheumatoid arthritis
Inflammation
      rheumatoid arthritis

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Faslpr
Allele Name lymphoproliferation
Allele Type Spontaneous
Common Name(s) Fas-; Fas-def; MRL/lpr; Tnfrf6lpr; Tnfrsf6lpr; Tnfrsf6lpr; lpr;
Strain of OriginMRL/Mp
Gene Symbol and Name Fas, Fas (TNF receptor superfamily member 6)
Chromosome 19
Gene Common Name(s) AI196731; ALPS1A; APO-1; APT1; CD95; FAS1; FASTM; TNF receptor superfamily member 6; TNFR6; TNFRSF6; Tnfrsf6; expressed sequence AI196731; lpr; lymphoproliferation;
General Note Faslpr, lymphoproliferation, recessive. This mutation was found during inbreeding of a strain MRL/Mp derived from crosses among strains LG, AKR, C3H, and C57BL/6. The resemblance has led to extensive use of Faslpr mice in attemptsto determine the etiology of SLE and to evaluate therapies. However, the human APT1 gene (OMIM 134637) encodes the FAS antigen; Tnfrsf6 is not the homolog of the human (SLE) gene.The Cd72c haplotype is a modifier of Faslpr-induced autoimmune disease. J:204782
Molecular Note Southern blotting experiments indicated that the mutation is a genomic rearrangement within the gene, probably within intron 2. [MGI Ref ID J:1181] [MGI Ref ID J:14206] [MGI Ref ID J:14503] [MGI Ref ID J:15429] [MGI Ref ID J:4166] [MGI Ref ID J:4342]

Genotyping

Genotyping Information

Genotyping Protocols

Faslpr, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Faslpr related

Adachi K; Tsutsui H; Kashiwamura S; Seki E; Nakano H; Takeuchi O; Takeda K; Okumura K; Van Kaer L; Okamura H; Akira S; Nakanishi K. 2001. Plasmodium berghei infection in mice induces liver injury by an IL-12- and toll-like receptor/myeloid differentiation factor 88-dependent mechanism. J Immunol 167(10):5928-34. [PubMed: 11698470]  [MGI Ref ID J:118004]

Adachi M; Watanabe-Fukunaga R; Nagata S. 1993. Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice. Proc Natl Acad Sci U S A 90(5):1756-60. [PubMed: 7680478]  [MGI Ref ID J:4342]

Affourtit C; Jastroch M; Brand MD. 2011. Uncoupling protein-2 attenuates glucose-stimulated insulin secretion in INS-1E insulinoma cells by lowering mitochondrial reactive oxygen species. Free Radic Biol Med 50(5):609-16. [PubMed: 21172424]  [MGI Ref ID J:168471]

Ahuja A; Teichmann LL; Wang H; Dunn R; Kehry MR; Shlomchik MJ. 2011. An acquired defect in IgG-dependent phagocytosis explains the impairment in antibody-mediated cellular depletion in Lupus. J Immunol 187(7):3888-94. [PubMed: 21873531]  [MGI Ref ID J:179332]

Aicher WK; Fujihashi K; Yamamoto M; Kiyono H; Pitts AM; McGhee JR. 1992. Effects of the lpr/lpr mutation on T and B cell populations in the lamina propria of the small intestine, a mucosal effector site. Int Immunol 4(9):959-68. [PubMed: 1390438]  [MGI Ref ID J:3154]

Ait-Azzouzene D; Kono DH; Gonzalez-Quintial R; McHeyzer-Williams LJ; Lim M; Wickramarachchi D; Gerdes T; Gavin AL; Skog P; McHeyzer-Williams MG; Nemazee D; Theofilopoulos AN. 2010. Deletion of IgG-switched autoreactive B cells and defects in Fas(lpr) lupus mice. J Immunol 185(2):1015-27. [PubMed: 20554953]  [MGI Ref ID J:161936]

Akashi T; Nagafuchi S; Anzai K; Kitamura D; Wang J; Taniuchi I; Niho Y; Watanabe T. 1998. Proliferation of CD3+ B220- single-positive normal T cells was suppressed in B-cell-deficient lpr mice. Immunology 93(2):238-48. [PubMed: 9616374]  [MGI Ref ID J:45808]

Akiyama K; Chen C; Wang D; Xu X; Qu C; Yamaza T; Cai T; Chen W; Sun L; Shi S. 2012. Mesenchymal-stem-cell-induced immunoregulation involves FAS-ligand-/FAS-mediated T cell apoptosis. Cell Stem Cell 10(5):544-55. [PubMed: 22542159]  [MGI Ref ID J:185809]

Al Gadban MM; German J; Truman JP; Soodavar F; Riemer EC; Twal WO; Smith KJ; Heller D; Hofbauer AF; Oates JC; Hammad SM. 2012. Lack of nitric oxide synthases increases lipoprotein immune complex deposition in the aorta and elevates plasma sphingolipid levels in lupus. Cell Immunol 276(1-2):42-51. [PubMed: 22560558]  [MGI Ref ID J:188295]

Al-Shami A; Crisostomo J; Wilkins C; Xu N; Humphries J; Chang WC; Anderson SJ; Oravecz T. 2013. Integrin-alpha FG-GAP repeat-containing protein 2 is critical for normal B cell differentiation and controls disease development in a lupus model. J Immunol 191(7):3789-98. [PubMed: 23997217]  [MGI Ref ID J:205951]

Alarcon-Riquelme ME; Fernandez C. 1995. CDR3 regions in the preimmune VH B cell repertoire of lpr mice. Clin Exp Immunol 101(1):73-7. [PubMed: 7621595]  [MGI Ref ID J:26829]

Alarcon-Riquelme ME; Fernandez C. 1995. Expression of the B cell repertoire in lpr mice; abnormal expansion of a few VHJ558 germ-line genes. Clin Exp Immunol 99(2):262-8. [PubMed: 7851020]  [MGI Ref ID J:22861]

Alenzi FQ; Marley SB; Lewis JL; Chandrashekran A; Warrens AN; Goldman JM; Gordon MY. 2002. A role for the Fas/Fas ligand apoptotic pathway in regulating myeloid progenitor cell kinetics. Exp Hematol 30(12):1428-35. [PubMed: 12482505]  [MGI Ref ID J:118008]

Alexander JJ; Jacob A; Bao L; Macdonald RL; Quigg RJ. 2005. Complement-dependent apoptosis and inflammatory gene changes in murine lupus cerebritis. J Immunol 175(12):8312-9. [PubMed: 16339572]  [MGI Ref ID J:122254]

Alexander JJ; Jacob A; Vezina P; Sekine H; Gilkeson GS; Quigg RJ. 2007. Absence of functional alternative complement pathway alleviates lupus cerebritis. Eur J Immunol 37(6):1691-701. [PubMed: 17523212]  [MGI Ref ID J:123511]

Alexander JJ; Zwingmann C; Jacob A; Quigg R. 2007. Alteration in kidney glucose and amino acids are implicated in renal pathology in MRL/lpr mice. Biochim Biophys Acta 1772(10):1143-9. [PubMed: 17942282]  [MGI Ref ID J:130687]

Alexander JJ; Zwingmann C; Quigg R. 2005. MRL/lpr mice have alterations in brain metabolism as shown with [1H-13C] NMR spectroscopy. Neurochem Int 47(1-2):143-51. [PubMed: 15893408]  [MGI Ref ID J:129820]

Ali M; Weinreich M; Balcaitis S; Cooper CJ; Fink PJ. 2003. Differential regulation of peripheral CD4+ T cell tolerance induced by deletion and TCR revision. J Immunol 171(11):6290-6. [PubMed: 14634147]  [MGI Ref ID J:132828]

Allam R; Pawar RD; Kulkarni OP; Hornung V; Hartmann G; Segerer S; Akira S; Endres S; Anders HJ. 2008. Viral 5'-triphosphate RNA and non-CpG DNA aggravate autoimmunity and lupus nephritis via distinct TLR-independent immune responses. Eur J Immunol 38(12):3487-3498. [PubMed: 19009528]  [MGI Ref ID J:141388]

Allison J; Thomas HE; Catterall T; Kay TW; Strasser A. 2005. Transgenic expression of dominant-negative Fas-associated death domain protein in beta cells protects against Fas ligand-induced apoptosis and reduces spontaneous diabetes in nonobese diabetic mice. J Immunol 175(1):293-301. [PubMed: 15972661]  [MGI Ref ID J:100606]

Alsharifi M; Lobigs M; Simon MM; Kersten A; Muller K; Koskinen A; Lee E; Mullbacher A. 2006. NK cell-mediated immunopathology during an acute viral infection of the CNS. Eur J Immunol 36(4):887-96. [PubMed: 16541469]  [MGI Ref ID J:114787]

Altman A. 1994. Abnormal antigen receptor-initiated signal transduction in lpr T lymphocytes. Semin Immunol 6(1):9-17. [PubMed: 7513195]  [MGI Ref ID J:19053]

Amital H; Heilweil M; Ulmansky R; Szafer F; Bar-Tana R; Morel L; Foster MH; Mostoslavsky G; Eilat D; Pizov G; Naparstek Y. 2005. Treatment with a laminin-derived peptide suppresses lupus nephritis. J Immunol 175(8):5516-23. [PubMed: 16210660]  [MGI Ref ID J:119103]

Anderson CC; Mukherjee R; Sinclair NR; Jevnikar AM. 1997. Hypogammaglobulinaemia occurs in Fas-deficient MRL-lpr mice following deletion of MHC class II molecules. Clin Exp Immunol 109(3):473-9. [PubMed: 9328125]  [MGI Ref ID J:42959]

Andrews BS; Eisenberg RA; Theofilopoulos AN; Izui S; Wilson CB; McConahey PJ; Murphy ED; Roths JB; Dixon FJ. 1978. Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains. J Exp Med 148(5):1198-215. [PubMed: 309911]  [MGI Ref ID J:27634]

Andrews SF; Zhang Q; Lim S; Li L; Lee JH; Zheng NY; Huang M; Taylor WM; Farris AD; Ni D; Meng W; Luning Prak ET; Wilson PC. 2013. Global analysis of B cell selection using an immunoglobulin light chain-mediated model of autoreactivity. J Exp Med 210(1):125-42. [PubMed: 23267014]  [MGI Ref ID J:194594]

Andryushkova AA; Kuznetsova IA; Orlovskaya IA; Buneva VN; Nevinsky GA. 2009. Nucleotide-hydrolyzing antibodies from the sera of autoimmune-prone MRL-lpr/lpr mice. Int Immunol 21(8):935-45. [PubMed: 19556305]  [MGI Ref ID J:151679]

Antoni A; Patel VA; Fan H; Lee DJ; Graham LH; Rosch CL; Spiegel DS; Rauch J; Levine JS. 2011. Macrophages from lupus-prone MRL mice have a conditional signaling abnormality that leads to dysregulated expression of numerous genes. Immunogenetics 63(5):291-308. [PubMed: 21229240]  [MGI Ref ID J:192148]

Aprahamian T; Bonegio RG; Richez C; Yasuda K; Chiang LK; Sato K; Walsh K; Rifkin IR. 2009. The peroxisome proliferator-activated receptor gamma agonist rosiglitazone ameliorates murine lupus by induction of adiponectin. J Immunol 182(1):340-6. [PubMed: 19109165]  [MGI Ref ID J:142895]

Apte RS; Richter J; Herndon J; Ferguson TA. 2006. Macrophages inhibit neovascularization in a murine model of age-related macular degeneration. PLoS Med 3(8):e310. [PubMed: 16903779]  [MGI Ref ID J:134144]

Arens R; Baars PA; Jak M; Tesselaar K; van der Valk M; van Oers MH; van Lier RA. 2005. Cutting edge: CD95 maintains effector T cell homeostasis in chronic immune activation. J Immunol 174(10):5915-20. [PubMed: 15879081]  [MGI Ref ID J:98994]

Arnold CN; Pirie E; Dosenovic P; McInerney GM; Xia Y; Wang N; Li X; Siggs OM; Karlsson Hedestam GB; Beutler B. 2012. A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity. Proc Natl Acad Sci U S A :. [PubMed: 22761313]  [MGI Ref ID J:185495]

Ashany D; Savir A; Bhardwaj N; Elkon KB. 1999. Dendritic cells are resistant to apoptosis through the Fas (CD95/APO-1) pathway. J Immunol 163(10):5303-11. [PubMed: 10553053]  [MGI Ref ID J:118433]

Baccala R; Gonzalez-Quintial R; Blasius AL; Rimann I; Ozato K; Kono DH; Beutler B; Theofilopoulos AN. 2013. Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus. Proc Natl Acad Sci U S A 110(8):2940-5. [PubMed: 23382217]  [MGI Ref ID J:194543]

Baccala R; Gonzalez-Quintial R; Schreiber RD; Lawson BR; Kono DH; Theofilopoulos AN. 2012. Anti-IFN-alpha/beta Receptor Antibody Treatment Ameliorates Disease in Lupus-Predisposed Mice. J Immunol 189(12):5976-84. [PubMed: 23175700]  [MGI Ref ID J:190844]

Balasa B; Van Gunst K; Jung N; Balakrishna D; Santamaria P; Hanafusa T; Itoh N; Sarvetnick N. 2000. Islet-specific expression of IL-10 promotes diabetes in nonobese diabetic mice independent of Fas, perforin, TNF receptor-1, and TNF receptor-2 molecules. J Immunol 165(5):2841-9. [PubMed: 10946317]  [MGI Ref ID J:64051]

Balkow S; Kersten A; Tran TT; Stehle T; Grosse P; Museteanu C; Utermohlen O; Pircher H; von Weizsacker F; Wallich R; Mullbacher A; Simon MM. 2001. Concerted action of the FasL/Fas and perforin/granzyme A and B pathways is mandatory for the development of early viral hepatitis but not for recovery from viral infection. J Virol 75(18):8781-91. [PubMed: 11507223]  [MGI Ref ID J:71217]

Bao L; Haas M; Boackle SA; Kraus DM; Cunningham PN; Park P; Alexander JJ; Anderson RK; Culhane K; Holers VM; Quigg RJ. 2002. Transgenic expression of a soluble complement inhibitor protects against renal disease and promotes survival in MRL/lpr mice. J Immunol 168(7):3601-7. [PubMed: 11907125]  [MGI Ref ID J:75572]

Bao L; Haas M; Quigg RJ. 2011. Complement factor H deficiency accelerates development of lupus nephritis. J Am Soc Nephrol 22(2):285-95. [PubMed: 21148254]  [MGI Ref ID J:185884]

Bao L; Osawe I; Haas M; Quigg RJ. 2005. Signaling through up-regulated C3a receptor is key to the development of experimental lupus nephritis. J Immunol 175(3):1947-55. [PubMed: 16034139]  [MGI Ref ID J:107265]

Barazzone C; Horowitz S; Donati YR; Rodriguez I; Piguet PF. 1998. Oxygen toxicity in mouse lung: pathways to cell death. Am J Respir Cell Mol Biol 19(4):573-81. [PubMed: 9761753]  [MGI Ref ID J:51593]

Barker TT; Lee PY; Kelly-Scumpia KM; Weinstein JS; Nacionales DC; Kumagai Y; Akira S; Croker BP; Sobel ES; Reeves WH; Satoh M. 2011. Pathogenic role of B cells in the development of diffuse alveolar hemorrhage induced by pristane. Lab Invest 91(10):1540-50. [PubMed: 21808234]  [MGI Ref ID J:176270]

Barreiro R; Luker G; Herndon J; Ferguson TA. 2004. Termination of antigen-specific immunity by CD95 ligand (Fas ligand) and IL-10. J Immunol 173(3):1519-25. [PubMed: 15265879]  [MGI Ref ID J:92022]

Barrington RA; Zhang M; Zhong X; Jonsson H; Holodick N; Cherukuri A; Pierce SK; Rothstein TL; Carroll MC. 2005. CD21/CD19 coreceptor signaling promotes B cell survival during primary immune responses. J Immunol 175(5):2859-67. [PubMed: 16116172]  [MGI Ref ID J:113242]

Bashratyan R; Sheng H; Regn D; Rahman MJ; Dai YD. 2013. Insulinoma-released exosomes activate autoreactive marginal zone-like B cells that expand endogenously in prediabetic NOD mice. Eur J Immunol 43(10):2588-97. [PubMed: 23817982]  [MGI Ref ID J:201680]

Bernstein KA; Bolshoun D; Lefkowith JB. 1993. Serum glomerular binding activity is highly correlated with renal disease in MRL/lpr mice. Clin Exp Immunol 93(3):418-23. [PubMed: 8370169]  [MGI Ref ID J:15039]

Bhandoola A; Yui K; Siegel RM; Zerva L; Greene MI. 1994. Gld and lpr mice: single gene mutant models for failed self tolerance. Int Rev Immunol 11(3):231-44. [PubMed: 7930847]  [MGI Ref ID J:21989]

Blair PA; Chavez-Rueda KA; Evans JG; Shlomchik MJ; Eddaoudi A; Isenberg DA; Ehrenstein MR; Mauri C. 2009. Selective targeting of B cells with agonistic anti-CD40 is an efficacious strategy for the generation of induced regulatory T2-like B cells and for the suppression of lupus in MRL/lpr mice. J Immunol 182(6):3492-502. [PubMed: 19265127]  [MGI Ref ID J:145926]

Bloch DB; Rabkina D; Bloch KD. 1995. The cell proliferation-associated protein Ki-67 is a target of autoantibodies in the serum of MRL mice. Lab Invest 73(3):366-71. [PubMed: 7564269]  [MGI Ref ID J:28749]

Bloom DD; Davignon JL; Cohen PL; Eisenberg RA; Clarke SH. 1993. Overlap of the anti-Sm and anti-DNA responses of MRL/Mp-lpr/lpr mice. J Immunol 150(4):1579-90. [PubMed: 8432994]  [MGI Ref ID J:3924]

Boggio E; Clemente N; Mondino A; Cappellano G; Orilieri E; Gigliotti CL; Toth E; Ramenghi U; Dianzani U; Chiocchetti A. 2014. IL-17 protects T cells from apoptosis and contributes to development of ALPS-like phenotypes. Blood 123(8):1178-86. [PubMed: 24363402]  [MGI Ref ID J:208695]

Bokers S; Urbat A; Daniel C; Amann K; Smith KG; Espeli M; Nitschke L. 2014. Siglec-G deficiency leads to more severe collagen-induced arthritis and earlier onset of lupus-like symptoms in MRL/lpr mice. J Immunol 192(7):2994-3002. [PubMed: 24600033]  [MGI Ref ID J:210020]

Bolland S; Yim YS; Tus K; Wakeland EK; Ravetch JV. 2002. Genetic modifiers of systemic lupus erythematosus in FcgammaRIIB(-/-) mice. J Exp Med 195(9):1167-74. [PubMed: 11994421]  [MGI Ref ID J:76486]

Bonardelle D; Benihoud K; Kiger N; Bobe P. 2005. B lymphocytes mediate Fas-dependent cytotoxicity in MRL/lpr mice. J Leukoc Biol 78(5):1052-1059. [PubMed: 16204618]  [MGI Ref ID J:102764]

Booker JK; Reap EA; Cohen PL. 1998. Expression and function of Fas on cells damaged by gamma-irradiation in B6 and B6/lpr mice. J Immunol 161(9):4536-41. [PubMed: 9794379]  [MGI Ref ID J:112150]

Boone DL; Dassopoulos T; Chai S; Chien M; Lodolce J; Ma A. 2003. Fas is not essential for lamina propria T lymphocyte homeostasis. Am J Physiol Gastrointest Liver Physiol 285(2):G382-8. [PubMed: 12702495]  [MGI Ref ID J:84826]

Bossaller L; Chiang PI; Schmidt-Lauber C; Ganesan S; Kaiser WJ; Rathinam VA; Mocarski ES; Subramanian D; Green DR; Silverman N; Fitzgerald KA; Marshak-Rothstein A; Latz E. 2012. Cutting Edge: FAS (CD95) Mediates Noncanonical IL-1beta and IL-18 Maturation via Caspase-8 in an RIP3-Independent Manner. J Immunol 189(12):5508-12. [PubMed: 23144495]  [MGI Ref ID J:190865]

Bossu P; Singer GG; Andres P; Ettinger R; Marshak-Rothstein A; Abbas AK. 1993. Mature CD4+ T lymphocytes from MRL/lpr mice are resistant to receptor-mediated tolerance and apoptosis. J Immunol 151(12):7233-9. [PubMed: 7903104]  [MGI Ref ID J:16035]

Bour-Jordan H; Thompson HL; Bluestone JA. 2005. Distinct effector mechanisms in the development of autoimmune neuropathy versus diabetes in nonobese diabetic mice. J Immunol 175(9):5649-55. [PubMed: 16237054]  [MGI Ref ID J:119359]

Bowen DG; Warren A; Davis T; Hoffmann MW; McCaughan GW; De St Groth BF; Bertolino P. 2002. Cytokine-dependent bystander hepatitis due to intrahepatic murine CD8 T-cell activation by bone marrow-derived cells. Gastroenterology 123(4):1252-64. [PubMed: 12360486]  [MGI Ref ID J:79335]

Bradshaw S; Zheng WJ; Tsoi LC; Gilkeson G; Zhang XK. 2008. A role for Fli-1 in B cell proliferation: implications for SLE pathogenesis. Clin Immunol 129(1):19-30. [PubMed: 18692443]  [MGI Ref ID J:140403]

Brard F; Shannon M; Prak EL; Litwin S; Weigert M. 1999. Somatic mutation and light chain rearrangement generate autoimmunity in anti-single-stranded DNA transgenic MRL/lpr mice. J Exp Med 190(5):691-704. [PubMed: 10477553]  [MGI Ref ID J:57612]

Braun D; Geraldes P; Demengeot J. 2003. Type I Interferon controls the onset and severity of autoimmune manifestations in lpr mice. J Autoimmun 20(1):15-25. [PubMed: 12604309]  [MGI Ref ID J:82338]

Breneman SM; Moynihan JA; Grota LJ; Felten DL; Felten SY. 1993. Splenic norepinephrine is decreased in MRL-lpr/lpr mice. Brain Behav Immun 7(2):135-43. [PubMed: 8347895]  [MGI Ref ID J:12758]

Brien JD; Uhrlaub JL; Nikolich-Zugich J. 2008. West nile virus-specific CD4 T cells exhibit direct antiviral cytokine secretion and cytotoxicity and are sufficient for antiviral protection. J Immunol 181(12):8568-75. [PubMed: 19050276]  [MGI Ref ID J:142059]

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Wingender G; Krebs P; Beutler B; Kronenberg M. 2010. Antigen-specific cytotoxicity by invariant NKT cells in vivo is CD95/CD178-dependent and is correlated with antigenic potency. J Immunol 185(5):2721-9. [PubMed: 20660713]  [MGI Ref ID J:163266]

Wofsy D; Murphy ED; Roths JB; Dauphinee MJ; Kipper SB; Talal N. 1981. Deficient interleukin 2 activity in MRL/Mp and C57BL/6J mice bearing the lpr gene. J Exp Med 154(5):1671-80. [PubMed: 6975351]  [MGI Ref ID J:6638]

Wong ML; Young JS; Nilaver G; Morton JI; Trune DR. 1992. Cochlear IgG in the C3H/lpr autoimmune strain mouse. Hear Res 59(1):93-100. [PubMed: 1629052]  [MGI Ref ID J:943]

Woo J; Wright TM; Lemster B; Borochovitz D; Nalesnik MA; Thomson AW. 1995. Combined effects of FK506 (tacrolimus) and cyclophosphamide on atypical B220+ T cells, cytokine gene expression and disease activity in MRL/MpJ-lpr/lpr mice. Clin Exp Immunol 100(1):118-25. [PubMed: 7535208]  [MGI Ref ID J:25139]

Woodworth JS; Wu Y; Behar SM. 2008. Mycobacterium tuberculosis-specific CD8+ T cells require perforin to kill target cells and provide protection in vivo. J Immunol 181(12):8595-603. [PubMed: 19050279]  [MGI Ref ID J:142057]

Wu J; Zhou T; Zhang J; He J; Gause WC; Mountz JD. 1994. Correction of accelerated autoimmune disease by early replacement of the mutated lpr gene with the normal Fas apoptosis gene in the T cells of transgenic MRL-lpr/lpr mice. Proc Natl Acad Sci U S A 91(6):2344-8. [PubMed: 7510888]  [MGI Ref ID J:17253]

Wu X; Jiang N; Deppong C; Singh J; Dolecki G; Mao D; Morel L; Molina HD. 2002. A role for the Cr2 gene in modifying autoantibody production in systemic lupus erythematosus. J Immunol 169(3):1587-92. [PubMed: 12133988]  [MGI Ref ID J:78006]

Wueest S; Rapold RA; Schoenle EJ; Konrad D. 2010. Fas activation in adipocytes impairs insulin-stimulated glucose uptake by reducing Akt. FEBS Lett 584(19):4187-92. [PubMed: 20828573]  [MGI Ref ID J:164421]

Wueest S; Rapold RA; Schumann DM; Rytka JM; Schildknecht A; Nov O; Chervonsky AV; Rudich A; Schoenle EJ; Donath MY; Konrad D. 2010. Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice. J Clin Invest 120(1):191-202. [PubMed: 19955656]  [MGI Ref ID J:156776]

Xanthoulea S; Pasparakis M; Kousteni S; Brakebusch C; Wallach D; Bauer J; Lassmann H; Kollias G. 2004. Tumor necrosis factor (TNF) receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious and inflammatory diseases. J Exp Med 200(3):367-76. [PubMed: 15289505]  [MGI Ref ID J:92470]

Xiang Z; Cutler AJ; Brownlie RJ; Fairfax K; Lawlor KE; Severinson E; Walker EU; Manz RA; Tarlinton DM; Smith KG. 2007. FcgammaRIIb controls bone marrow plasma cell persistence and apoptosis. Nat Immunol 8(4):419-29. [PubMed: 17322888]  [MGI Ref ID J:120734]

Xiao S; Brooks CR; Zhu C; Wu C; Sweere JM; Petecka S; Yeste A; Quintana FJ; Ichimura T; Sobel RA; Bonventre JV; Kuchroo VK. 2012. Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice. Proc Natl Acad Sci U S A 109(30):12105-10. [PubMed: 22773818]  [MGI Ref ID J:186484]

Xiao S; Sung SS; Fu SM; Ju ST. 2003. Combining Fas mutation with interleukin-2 deficiency prevents Colitis and Lupus: implicating interleukin-2 for auto-reactive T cell expansion and Fas ligand for colon epithelial cell death. J Biol Chem 278(52):52730-8. [PubMed: 14525977]  [MGI Ref ID J:87085]

Xiao Y; Li H; Zhang J; Volk A; Zhang S; Wei W; Zhang S; Breslin P; Zhang J. 2011. TNF-alpha/Fas-RIP-1-induced cell death signaling separates murine hematopoietic stem cells/progenitors into 2 distinct populations. Blood 118(23):6057-67. [PubMed: 21989986]  [MGI Ref ID J:179087]

Xie C; Patel R; Wu T; Zhu J; Henry T; Bhaskarabhatla M; Samudrala R; Tus K; Gong Y; Zhou H; Wakeland EK; Zhou XJ; Mohan C. 2007. PI3K/AKT/mTOR hypersignaling in autoimmune lymphoproliferative disease engendered by the epistatic interplay of Sle1b and FASlpr. Int Immunol 19(4):509-22. [PubMed: 17369192]  [MGI Ref ID J:120119]

Xie Y; Zhang H; Li W; Deng Y; Munegowda MA; Chibbar R; Qureshi M; Xiang J. 2010. Dendritic cells recruit T cell exosomes via exosomal LFA-1 leading to inhibition of CD8+ CTL responses through downregulation of peptide/MHC class I and Fas ligand-mediated cytotoxicity. J Immunol 185(9):5268-78. [PubMed: 20881190]  [MGI Ref ID J:165185]

Xu B; Bulfone-Paus S; Aoyama K; Yu S; Huang P; Morimoto K; Matsushita T; Takeuchi T. 2003. Role of Fas/Fas ligand-mediated apoptosis in murine contact hypersensitivity. Int Immunopharmacol 3(7):927-38. [PubMed: 12810350]  [MGI Ref ID J:106217]

Xu H; Kurihara H; Ito T; Nakajima SI; Hagiwara E; Yamanokuchi H; Asari A. 2001. IL-12 Enhances Lymphoaccumulation by Suppressing Cell Death of T Cells in MRL- lpr/lpr Mice. J Autoimmun 16(2):87-95. [PubMed: 11247634]  [MGI Ref ID J:68152]

Xu JP; Li X; Mori E; Guo MW; Mori T. 1998. Aberrant expression and dysfunction of Fas antigen in MRL/MpJ-lpr/lpr murine ovary. Zygote 6(4):359-67. [PubMed: 9921647]  [MGI Ref ID J:55597]

Xu M; Hou R; Sato-Hayashizaki A; Man R; Zhu C; Wakabayashi C; Hirose S; Adachi T; Tsubata T. 2013. Cd72(c) is a modifier gene that regulates Fas(lpr)-induced autoimmune disease. J Immunol 190(11):5436-45. [PubMed: 23616572]  [MGI Ref ID J:204782]

Yajima K; Nakamura A; Sugahara A; Takai T. 2003. FcgammaRIIB deficiency with Fas mutation is sufficient for the development of systemic autoimmune disease. Eur J Immunol 33(4):1020-9. [PubMed: 12672068]  [MGI Ref ID J:82862]

Yamagiwa S; Kuwano Y; Hasegawa K; Sato K; Ohtsuka K; Iiai T; Tomiyama K; Watanabe H; Sugahara S; Seki S; Asakura H; Abo T. 1996. Existence of a small population of IL-2R beta hi TCRint cells in SCG and MRL-lpr/lpr mice which produce normal Fas mRNA and Fas molecules from the lpr gene. Eur J Immunol 26(7):1409-16. [PubMed: 8766540]  [MGI Ref ID J:34166]

Yamagiwa S; Sugahara S; Shimizu T; Iwanaga T; Yoshida Y; Honda S; Watanabe H; Suzuki K; Asakura H; Abo T. 1998. The primary site of CD4- 8- B220+ alphabeta T cells in lpr mice: the appendix in normal mice. J Immunol 160(6):2665-74. [PubMed: 9510165]  [MGI Ref ID J:111332]

Yan J; Harvey BP; Gee RJ; Shlomchik MJ; Mamula MJ. 2006. B cells drive early T cell autoimmunity in vivo prior to dendritic cell-mediated autoantigen presentation. J Immunol 177(7):4481-7. [PubMed: 16982884]  [MGI Ref ID J:139321]

Yan J; Mamula MJ. 2002. B and T cell tolerance and autoimmunity in autoantibody transgenic mice. Int Immunol 14(8):963-71. [PubMed: 12147633]  [MGI Ref ID J:131498]

Yanaba K; Bouaziz JD; Matsushita T; Tsubata T; Tedder TF. 2009. The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals. J Immunol 182(12):7459-72. [PubMed: 19494269]  [MGI Ref ID J:149301]

Yanagi K; Haneji N; Hamano H; Takahashi M; Higashiyama H; Hayashi Y. 1996. In vivo role of IL-10 and IL-12 during development of Sjogren's syndrome in MRL/Lpr mice. Cell Immunol 168(2):243-50. [PubMed: 8640871]  [MGI Ref ID J:31851]

Yang CH; Tian L; Ling GS; Trendell-Smith NJ; Ma L; Lo CK; Stott DI; Liew FY; Huang FP. 2008. Immunological mechanisms and clinical implications of regulatory T cell deficiency in a systemic autoimmune disorder: Roles of IL-2 versus IL-15. Eur J Immunol 38(6):1664-76. [PubMed: 18465774]  [MGI Ref ID J:136193]

Yang JQ; Chun T; Liu H; Hong S; Bui H; Van Kaer L; Wang CR; Singh RR. 2004. CD1d deficiency exacerbates inflammatory dermatitis in MRL-lpr/lpr mice. Eur J Immunol 34(6):1723-32. [PubMed: 15162443]  [MGI Ref ID J:90394]

Yang ML; Doyle HA; Gee RJ; Lowenson JD; Clarke S; Lawson BR; Aswad DW; Mamula MJ. 2006. Intracellular protein modification associated with altered T cell functions in autoimmunity. J Immunol 177(7):4541-9. [PubMed: 16982891]  [MGI Ref ID J:139320]

Yang X; Yang J; Chu Y; Wang J; Guan M; Zhu X; Xue Y; Zou H. 2013. T follicular helper cells mediate expansion of regulatory B cells via IL-21 in Lupus-prone MRL/lpr mice. PLoS One 8(4):e62855. [PubMed: 23638156]  [MGI Ref ID J:200873]

Yasuda T; Kuwabara T; Nakano H; Aritomi K; Onodera T; Lipp M; Takahama Y; Kakiuchi T. 2007. Chemokines CCL19 and CCL21 promote activation-induced cell death of antigen-responding T cells. Blood 109(2):449-56. [PubMed: 16973962]  [MGI Ref ID J:144008]

Yasuda T; Zhang Y; Nagase H; Kaneko T; Sayama K; Hashimoto H; Matsuzawa A. 2000. Immunological characterization of C3H mice congenic for Fas(lprcg), C3h/HeJ-Fas(lprcg)/Fas(lprcg). Lab Anim 34(1):46-55. [PubMed: 10759366]  [MGI Ref ID J:59981]

Yasutomo K; Maeda K; Hisaeda H; Good RA; Kuroda Y; Himeno K. 1997. The Fas-deficient SCID mouse exhibits the development of T cells in the thymus. J Immunol 158(10):4729-33. [PubMed: 9144486]  [MGI Ref ID J:40207]

Yin Y; Stahl BC; DeWolf WC; Morgentaler A. 2002. P53 and Fas are sequential mechanisms of testicular germ cell apoptosis. J Androl 23(1):64-70. [PubMed: 11780924]  [MGI Ref ID J:105850]

Yin Z; Bahtiyar G; Zhang N; Liu L; Zhu P; Robert ME; McNiff J; Madaio MP; Craft J. 2002. IL-10 regulates murine lupus. J Immunol 169(4):2148-55. [PubMed: 12165544]  [MGI Ref ID J:78239]

Yoh K; Itoh K; Enomoto A; Hirayama A; Yamaguchi N; Kobayashi M; Morito N; Koyama A; Yamamoto M; Takahashi S. 2001. Nrf2-deficient female mice develop lupus-like autoimmune nephritis. Kidney Int 60(4):1343-53. [PubMed: 11576348]  [MGI Ref ID J:104016]

Yoshida T; Higuchi T; Hagiyama H; Strasser A; Nishioka K; Tsubata T. 2000. Rapid B cell apoptosis induced by antigen receptor ligation does not require fas (CD95/APO-1), the adaptor protein FADD/MORT1 or CrmA-sensitive caspases but is defective in both MRL-+/+ and MRL-lpr/lpr mice Int Immunol 12(4):517-26. [PubMed: 10744653]  [MGI Ref ID J:61691]

Yoshizawa Y; Honda S; Shibuya A. 2014. Involvement of Fcalpha/muR (CD351) in autoantibody production. Mol Immunol 57(2):216-9. [PubMed: 24172225]  [MGI Ref ID J:206184]

Youd ME; Luus L; Corley RB. 2004. IgM monomers accelerate disease manifestations in autoimmune-prone Fas-deficient mice. J Autoimmun 23(4):333-43. [PubMed: 15571927]  [MGI Ref ID J:94230]

Yui K; Wadsworth S; Yellen A; Hashimoto Y; Kokai Y; Greene MI. 1988. Molecular and functional properties of novel T cell subsets in C3H-gld/gld and nude mice. Implications for thymic and extrathymic maturation. Immunol Rev 104:121-55. [PubMed: 3049314]  [MGI Ref ID J:24681]

Zhang B; Hirahashi J; Cullere X; Mayadas TN. 2003. Elucidation of molecular events leading to neutrophil apoptosis following phagocytosis: cross-talk between caspase 8, reactive oxygen species, and MAPK/ERK activation. J Biol Chem 278(31):28443-54. [PubMed: 12736263]  [MGI Ref ID J:120441]

Zhang B; Kracker S; Yasuda T; Casola S; Vanneman M; Homig-Holzel C; Wang Z; Derudder E; Li S; Chakraborty T; Cotter SE; Koyama S; Currie T; Freeman GJ; Kutok JL; Rodig SJ; Dranoff G; Rajewsky K. 2012. Immune Surveillance and Therapy of Lymphomas Driven by Epstein-Barr Virus Protein LMP1 in a Mouse Model. Cell 148(4):739-51. [PubMed: 22341446]  [MGI Ref ID J:181546]

Zhang B; Maris CH; Foell J; Whitmire J; Niu L; Song J; Kwon BS; Vella AT; Ahmed R; Jacob J; Mittler RS. 2007. Immune suppression or enhancement by CD137 T cell costimulation during acute viral infection is time dependent. J Clin Invest 117(10):3029-41. [PubMed: 17853940]  [MGI Ref ID J:127406]

Zhang MC; Furukawa H; Tokunaka K; Saiga K; Date F; Owada Y; Nose M; Ono M. 2008. Mast cell hyperplasia in the skin of Dsg4-deficient hypotrichosis mice, which are long-living mutants of lupus-prone mice. Immunogenetics 60(10):599-607. [PubMed: 18677469]  [MGI Ref ID J:140028]

Zhang X; Shan P; Alam J; Davis RJ; Flavell RA; Lee PJ. 2003. Carbon monoxide modulates Fas/Fas ligand, caspases, and Bcl-2 family proteins via the p38alpha mitogen-activated protein kinase pathway during ischemia-reperfusion lung injury. J Biol Chem 278(24):22061-70. [PubMed: 12690100]  [MGI Ref ID J:211469]

Zhang XK; Gallant S; Molano I; Moussa OM; Ruiz P; Spyropoulos DD; Watson DK; Gilkeson G. 2004. Decreased expression of the Ets family transcription factor Fli-1 markedly prolongs survival and significantly reduces renal disease in MRL/lpr mice. J Immunol 173(10):6481-9. [PubMed: 15528390]  [MGI Ref ID J:94287]

Zhang Z; Kyttaris VC; Tsokos GC. 2009. The role of IL-23/IL-17 axis in lupus nephritis. J Immunol 183(5):3160-9. [PubMed: 19657089]  [MGI Ref ID J:151862]

Zhao Z; Deocharan B; Scherer PE; Ozelius LJ; Putterman C. 2006. Differential binding of cross-reactive anti-DNA antibodies to mesangial cells: the role of alpha-actinin. J Immunol 176(12):7704-14. [PubMed: 16751418]  [MGI Ref ID J:132348]

Zheng L; Sharma R; Gaskin F; Fu SM; Ju ST. 2007. A novel role of IL-2 in organ-specific autoimmune inflammation beyond regulatory T cell checkpoint: both IL-2 knockout and Fas mutation prolong lifespan of Scurfy mice but by different mechanisms. J Immunol 179(12):8035-41. [PubMed: 18056343]  [MGI Ref ID J:155041]

Zhou T; Bluethmann H; Eldridge J; Berry K; Mountz JD. 1993. Origin of CD4-CD8-B220+ T cells in MRL-lpr/lpr mice. Clues from a T cell receptor beta transgenic mouse. J Immunol 150(8 Pt 1):3651-67. [PubMed: 7682246]  [MGI Ref ID J:4525]

Zhou T; Edwards CK 3rd; Yang P; Wang Z; Bluethmann H; Mountz JD. 1996. Greatly accelerated lymphadenopathy and autoimmune disease in lpr mice lacking tumor necrosis factor receptor I. J Immunol 156(8):2661-5. [PubMed: 8609380]  [MGI Ref ID J:32463]

Ziebell JM; Bye N; Semple BD; Kossmann T; Morganti-Kossmann MC. 2011. Attenuated neurological deficit, cell death and lesion volume in Fas-mutant mice is associated with altered neuroinflammation following traumatic brain injury. Brain Res 1414:94-105. [PubMed: 21871613]  [MGI Ref ID J:176594]

Zielinski CE; Jacob SN; Bouzahzah F; Ehrlich BE; Craft J. 2005. Naive CD4+ T cells from lupus-prone Fas-intact MRL mice display TCR-mediated hyperproliferation due to intrinsic threshold defects in activation. J Immunol 174(8):5100-9. [PubMed: 15814741]  [MGI Ref ID J:98149]

Zimmermann C; Rawiel M; Blaser C; Kaufmann M; Pircher H. 1996. Homeostatic regulation of CD8+ T cells after antigen challenge in the absence of Fas (CD95). Eur J Immunol 26(12):2903-10. [PubMed: 8977284]  [MGI Ref ID J:37076]

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Zoukhri D; Kublin CL. 2001. Impaired neurotransmitter release from lacrimal and salivary gland nerves of a murine model of Sjogren's syndrome. Invest Ophthalmol Vis Sci 42(5):925-32. [PubMed: 11274068]  [MGI Ref ID J:68663]

Zuliani C; Kleber S; Klussmann S; Wenger T; Kenzelmann M; Schreglmann N; Martinez A; del Rio JA; Soriano E; Vodrazka P; Kuner R; Groene HJ; Herr I; Krammer PH; Martin-Villalba A. 2006. Control of neuronal branching by the death receptor CD95 (Fas/Apo-1). Cell Death Differ 13(1):31-40. [PubMed: 16003386]  [MGI Ref ID J:121029]

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Cryopreserved

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Price (US dollars $)
Cryorecovery* $2525.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

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Frozen Embryo $1650.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

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  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3283.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $2145.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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