Strain Name:

129S-Npytm1Rpa/J

Stock Number:

004545

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Availability:

Repository- Live

Use Restrictions Apply, see Terms of Use
Homozygous mutants in this lacZ reporter strain exhibit spontaneous and GABA induced seizures. These mice may be useful in studies related to the role of neuropeptide Y in obesity.

Description

Strain Information

Type Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Specieslaboratory mouse
GenerationN?+F?+F15 (24-MAR-11)
Generation Definitions
 
Donating InvestigatorDr. Richard Palmiter,   University of Washington

Description
Mice that are homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. No gene product (mRNA or protein) is detected by Northern or Western blot analysis of brain or adrenal gland tissue. Beta-galactosidase activity assays and in situ hybridization demonstrate similar expression patterns for the lacZ gene and the endogenous wildtype gene. Spontaneous seizures are exhibited by some mice at age 6 to 8 weeks. Homozygous mice are susceptible to seizures induced by GABA antagonist treatment. Mutant mice have an increased sensitivity to leptin treatment which results in a greater initial reduction of food intake and weight loss when compared to wildtype mice. This mutant mouse strain may be useful in studies related to the role of neuropeptide Y in obesity.

Development
A targeting vector containing neomycin resistance, thymidine kinase and lacZ reporter genes was used to disrupt exon 2 of the targeted gene. The construct was electroporated into 129S7/SvEvBrd-Hprt+ derived AB1 embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6 blastocysts.

Control Information

  Control
   002448 129S1/SvImJ (approximate)
 
  Considerations for Choosing Controls

Related Strains

lacZ Expression Strains
002484   129-Alpltm1Sor/J
002292   129-Gt(ROSA)26Sor/J
012756   129-Sirt4tm1Fwa/J
006050   129-Sirt6tm1Fwa/J
003451   129-Smad3tm1Par/J
003310   129S-Gt(ROSA)26Sortm1Sor/J
003383   129S-Nogtm1Amc/J
005091   129S-Pnpla6tm1Blw/J
007199   129S-Sgpl1Gt(ROSA)78Sor/J
003082   129S1/SvImJ-Bcl2tm1Mpin/J
010633   B6(Cg)-Gt(ROSA)26Sortm1(CAG-taulacZ)Bene/J
005085   B6.129(Cg)-Cd44tm1Hbg/J
012239   B6.129(Cg)-Cd44tm1Hbg/SjJ
004178   B6.129(Cg)-Tg(CAG-Bgeo/GFP)21Lbe/J
004478   B6.129-Foxd1tm1Lai/J
006939   B6.129-Fut1tm1Sdo/J
008606   B6.129-Gt(ROSA)26Sortm1Joe/J
005768   B6.129-Htr5atm1Dgen/J
002938   B6.129-Kdrtm1Jrt/J
004158   B6.129-Maftm1Gsb/J
006497   B6.129-Skiltm2Spw/J
009348   B6.129P2(Cg)-Hprttm17(Ple48-lacZ)Ems/Mmjax
012572   B6.129P2(Cg)-Hprttm19(Ple88-lacZ)Ems/Mmjax
012574   B6.129P2(Cg)-Hprttm38(Ple17-lacZ)Ems/Mmjax
012575   B6.129P2(Cg)-Hprttm39(Ple24-lacZ)Ems/Mmjax
012576   B6.129P2(Cg)-Hprttm40(Ple34-lacZ)Ems/Mmjax
010805   B6.129P2(Cg)-Hprttm41(Ple160-lacZ)Ems/Mmjax
012331   B6.129P2(Cg)-Hprttm42(Ple131-lacZ)Ems/Mmjax
012577   B6.129P2(Cg)-Hprttm43(Ple140-lacZ)Ems/Mmjax
010709   B6.129P2(Cg)-Hprttm44(Ple49-lacZ)Ems/Mmjax
012333   B6.129P2(Cg)-Hprttm45(Ple67-lacZ)Ems/Mmjax
012733   B6.129P2(Cg)-Hprttm53(CAG-lacZ)Ems/Mmjax
012578   B6.129P2(Cg)-Hprttm56(Ple25-lacZ)Ems/Mmjax
012579   B6.129P2(Cg)-Hprttm58(Ple119-lacZ)Ems/Mmjax
012580   B6.129P2(Cg)-Hprttm59(Ple123-lacZ)Ems/Mmjax
012581   B6.129P2(Cg)-Hprttm62(Ple153-lacZ)Ems/Mmjax
012342   B6.129P2(Cg)-Hprttm63(Ple12-lacZ)Ems/Mmjax
012347   B6.129P2(Cg)-Hprttm64(Ple170-lacZ)Ems/Mmjax
012582   B6.129P2(Cg)-Hprttm67(Ple238-lacZ)Ems/Mmjax
012583   B6.129P2(Cg)-Hprttm68(Ple127-lacZ)Ems/Mmjax
012656   B6.129P2(Cg)-Hprttm70(Ple240-lacZ)Ems/Mmjax
012657   B6.129P2(Cg)-Hprttm71(Ple155-lacZ)Ems/Mmjax
012659   B6.129P2(Cg)-Hprttm73(Ple142-lacZ)Ems/Mmjax
012734   B6.129P2(Cg)-Hprttm74(Ple232-lacZ)Ems/Mmjax
005772   B6.129P2-Acvrl1tm1Dgen/J
005770   B6.129P2-Adamts4tm1Dgen/J
005771   B6.129P2-Adamts5tm1Dgen/J
005773   B6.129P2-Adcy3tm1Dgen/J
005774   B6.129P2-Adcy7tm1Dgen/J
005775   B6.129P2-Adipor2tm1Dgen/J
005776   B6.129P2-Avpr1atm1Dgen/J
009120   B6.129P2-Axin2tm1Wbm/J
005777   B6.129P2-Axltm1Dgen/J
005783   B6.129P2-Cacna1ctm1Dgen/J
005780   B6.129P2-Cacna2d3tm1Dgen/J
005781   B6.129P2-Cacng3tm1Dgen/J
005782   B6.129P2-Cacng4tm1Dgen/J
005784   B6.129P2-Capn5tm1Dgen/J
005785   B6.129P2-Capn7tm1Dgen/J
005792   B6.129P2-Ccr1l1tm1Dgen/J
005793   B6.129P2-Ccr6tm1Dgen/J
005794   B6.129P2-Ccr7tm1Dgen/J
005779   B6.129P2-Celsr2tm1Dgen/J
005797   B6.129P2-Chrna2tm1Dgen/J
005787   B6.129P2-Ctsctm1Dgen/J
005796   B6.129P2-Cxcr3tm1Dgen/J
005798   B6.129P2-Drd5tm1Dgen/J
005800   B6.129P2-Efemp2tm1Dgen/J
005801   B6.129P2-Esrratm1Dgen/J
005802   B6.129P2-Faim2tm1Dgen/J
005803   B6.129P2-Fzd1tm1Dgen/J
005804   B6.129P2-Fzd8tm1Dgen/J
005811   B6.129P2-Gabra3tm1Dgen/J
005812   B6.129P2-Gabra4tm1Dgen/J
005810   B6.129P2-Gabrptm1Dgen/J
005809   B6.129P2-Galr1tm1Dgen/J
016094   B6.129P2-Git2Gt(XG510)Byg/WeisJ
005816   B6.129P2-Glra3tm1Dgen/J
005805   B6.129P2-Gpr151tm1Dgen/J
005806   B6.129P2-Gpr37tm1Dgen/J
005807   B6.129P2-Gpr6tm1Dgen/J
005813   B6.129P2-Grik5tm1Dgen/J
005808   B6.129P2-Grk5tm1Dgen/J
005814   B6.129P2-Grm1tm1Dgen/J
005815   B6.129P2-Grm3tm1Dgen/J
005817   B6.129P2-Gsk3btm1Dgen/J
005818   B6.129P2-Hcrtr1tm1Dgen/J
005767   B6.129P2-Htr4tm1Dgen/J
005769   B6.129P2-Htr7tm1Dgen/J
005830   B6.129P2-Kcnq2tm1Dgen/J
005821   B6.129P2-Lats2tm1Dgen/J
005822   B6.129P2-Lmbr1tm1Dgen/J
005850   B6.129P2-Mapkapk2tm1Dgen/J
005824   B6.129P2-Mmp17tm1Dgen/J
005825   B6.129P2-Mtmr1tm1Dgen/J
005826   B6.129P2-Ntsr1tm1Dgen/J
007767   B6.129P2-Olfr17tm1Mom/MomJ
005829   B6.129P2-Pkd2l2tm1Dgen/J
005828   B6.129P2-Ppardtm1Dgen/J
005831   B6.129P2-Ppm1ftm1Dgen/J
005827   B6.129P2-Ptch2tm1Dgen/J
005832   B6.129P2-Ptprotm1Dgen/J
005799   B6.129P2-S1pr4tm1Dgen/J
005837   B6.129P2-Scn11atm1Dgen/J
005836   B6.129P2-Scn9atm1Dgen/J
005834   B6.129P2-Sema5atm1Dgen/J
005835   B6.129P2-Sema6ctm1Dgen/J
006432   B6.129P2-Slc18a1tm1Dgen/J
005839   B6.129P2-Slc22a12tm1Dgen/J
005838   B6.129P2-Slc22a6tm1Dgen/J
005840   B6.129P2-Slc40a1tm1Dgen/J
005841   B6.129P2-Slc6a9tm1Dgen/J
005842   B6.129P2-Slc7a8tm1Dgen/J
005843   B6.129P2-Slc9a6tm1Dgen/J
012723   B6.129P2-Sptbn2Gt(XK442)Byg/LlpJ
005844   B6.129P2-Sstr1tm1Dgen/J
005847   B6.129P2-Tgfbr1tm1Dgen/J
005845   B6.129P2-Thbs4tm1Dgen/J
005790   B6.129P2-Tpp1tm1Dgen/J
005848   B6.129P2-Trpm5tm1Dgen/J
005791   B6.129P2-Xcr1tm1Dgen/J
012374   B6.129S-Artm1Rax/ShahJ
012377   B6.129S-Cyp19a1tm1.1Shah/J
009089   B6.129S1(Cg)-Ndntm2Stw/J
009386   B6.129S1-Osr2tm1Jian/J
007768   B6.129S2-Omptm1Mom/MomJ
003474   B6.129S4-Gt(ROSA)26Sortm1Sor/J
005901   B6.129S4-Ppardtm2Rev/J
006142   B6.129S4-Ppargtm1Rev/J
003754   B6.129S4-Shroom3Gt(ROSA53)Sor/J
013189   B6.129S5-Mlst8tm1Lex/J
013190   B6.129S5-MtorGt(OST92090)Lex/J
013191   B6.129S5-Rptortm1Lex/J
005119   B6.129S6-Npas2tm1Slm/J
002741   B6.129S7-Alpltm1Sor/J
005970   B6.129S7-Atoh1tm2Hzo/J
006039   B6.129S7-Efnb2tm1And/J
002192   B6.129S7-Gt(ROSA)26Sor/J
005981   B6.129S7-Rai1tm1Jrl/J
005039   B6.129X1-Adra1atm1Pcs/J
006262   B6.129X1-Fut2tm1Sdo/J
014536   B6.Cg-Hprttm75(Ple143-lacZ)Ems/Mmjax
007745   B6.Cg-Mir155tm1.1Rsky/J
005317   B6.Cg-Tg(BAT-lacZ)3Picc/J
003139   B6.Cg-Tg(DBHn-lacZ)8Rpk/J
006229   B6.Cg-Tg(DRE-lacZ)2Gswz/J
006773   B6.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd/J
024377   B6.Cg-Tg(TCF/Lef1-lacZ)34Efu/KatmJ
002982   B6.Cg-Tg(xstpx-lacZ)32And/J
008615   B6;129-Frzbtm1Nat/J
012820   B6;129-Fzd1tm1.1Nat/J
012821   B6;129-Fzd2tm1.1Nat/J
012822   B6;129-Fzd3tm1Nat/J
012824   B6;129-Fzd6tm1Nat/J
012825   B6;129-Fzd7tm1.1Nat/J
008516   B6;129-Gt(ROSA)26Sortm1Joe/J
003504   B6;129-Gt(ROSA)26Sortm1Sho/J
010590   B6;129-Iis1tm1(CAG-Bgeo,-tdTomato/TEVP,-SV2B/GFP)Nat/J
016857   B6;129-Itga7tm1Burk/J
018296   B6;129-Kcptm1Gdr/J
008614   B6;129-Sfrp2tm1Nat/J
012757   B6;129-Sirt5tm1Fwa/J
005064   B6;129-Slc30a3tm1Rpa/J
009599   B6;129P2-Adam19Gt(Betageo)1Bbl/J
006431   B6;129P2-Adam21tm1Dgen/J
005788   B6;129P2-Cd97tm1Dgen/J
006595   B6;129P2-Olfr17tm1Mom/MomJ
005833   B6;129P2-Rgs4tm1Dgen/J
012850   B6;129P2-TardbpGt(RRB030)Byg/J
002073   B6;129S-Gt(ROSA)26Sor/J
006470   B6;129S-Hopxtm1Eno/J
004153   B6;129S-Map7Gt(ROSABetageo)1Sor/J
006958   B6;129S-Nkd1tm1Kwha/J
006960   B6;129S-Nkd2tm1Kwha/J
006594   B6;129S2-Omptm1Mom/MomJ
007204   B6;129S4-2610005L07RikGt(ROSA)73Sor/J
011052   B6;129S4-Ctbp2Gt(ROSA61)Sor/J
003309   B6;129S4-Gt(ROSA)26Sortm1Sor/J
004365   B6;129S6-Srebf1tm1Mbr/J
002317   B6;129S7-Alpltm1Sor/J
003266   B6;129S7-Epas1tm1Rus/J
006044   B6;129S7-Ephb4tm1And/J
008618   B6;A-Tg(OPN1LW-lacZ)1Nat/J
003471   B6;C3H-Tg(CNP-GEO)1Ldh/J
006465   B6;CBA-Tg(CAG-lacZ-WGA)330Bbm/J
006680   B6;CBA-Tg(Olfr16*,taulacZ)19Mom/MomJ
006671   B6;CBA-Tg(Olfr16*,taulacZ)5Mom/MomJ
006672   B6;CBA-Tg(Olfr16*,taulacZ)7Mom/MomJ
006673   B6;CBA-Tg(Olfr16,taulacZ)sn2Mom/MomJ
004141   B6;CBA-Tg(UAS-lacZ)65Rth/J
008344   B6;DBA-Tg(Fos-tTA,Fos-EGFP*)1Mmay Tg(tetO-lacZ,tTA*)1Mmay/J
002369   B6;SJL-Tg(c177-lacZ)226Bri/J
002372   B6;SJL-Tg(c177-lacZ)227Bri/J
002621   B6;SJL-Tg(tetop-lacZ)2Mam/J
003299   B6;SWJ-Tg(TIMP3-lacZ)7Jeb/J
002865   B6CBA-Tg(Wnt1-lacZ)206Amc/J
016095   C.129P2(B6)-Git2Gt(XG510)Byg/WeisJ
016093   C.129S4(B6)-Git1Gt(FHCRC-GT-S10-12C1)Sor/WeisJ
002955   C.129S7-Gt(ROSA)26Sor/J
010683   C57BL/6-Enamtm1.1Jcch/J
010684   C57BL/6-Klk4tm1.1Jpsi/J
009062   C57BL/6-Magel2tm1Stw/J
002754   C57BL/6-Tg(LacZpl)60Vij/J
013729   C57BL/6-Tg(tetO-EDN1,-lacZ)9Mhus/J
013728   C57BL/6-Tg(tetO-NOS2,-lacZ)240iMhus/J
002193   C57BL/6J-Tg(MTn-lacZ)204Bri/J
002981   DBA/2-Tg(xstpx-lacZ)36And/J
004127   FVB-Tg(Nes-rtTA)306Rvs/J
007225   FVB.129(B6)-Usp18tm1Dzh/J
006214   FVB.129P2-Smn1tm1Msd/J
009427   FVB.129S4(B6)-Gt(ROSA)26Sortm1Sor/J
012429   FVB.Cg-Gt(ROSA)26Sortm1(CAG-lacZ,-EGFP)Glh/J
008206   FVB.Cg-Smn1tm1Msd Tg(SMN2)566Ahmb/J
008209   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(ACTA1-SMN)69Ahmb/J
005025   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
005026   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN1*A2G)2023Ahmb/J
005024   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd/J
003487   FVB.Cg-Tg(XGFAP-lacZ)3Mes/J
003140   FVB/N-Tg(PAI1-lacZ)1Jjb/J
002856   FVB/N-Tg(TIE2-lacZ)182Sato/J
005941   FVB/N-Tg(tetO-Aurkb,lacZ)41Kra/J
003315   FVB/N-Tg(tetORo1-lacZ)3Conk/J
005878   NOD.129(Cg)-Cd44tm1Hbg/J
003899   STOCK Cd44tm1Hbg/J
008602   STOCK Cdontm2Rsk/J
007912   STOCK En1tm2Alj/J
007925   STOCK En2tm5.1Alj/J
008211   STOCK Gli1tm2Alj/J
007922   STOCK Gli2tm2.1Alj/J
013123   STOCK Gt(ROSA)26Sortm6(Gli1)Amc/J
006241   STOCK Hhiptm1Amc/J
010707   STOCK Hprttm37(lacZ)Ems/Mmjax
012335   STOCK Hprttm50(Ple55-lacZ)Ems/Mmjax
013764   STOCK Hprttm57(Ple26-lacZ)Ems/Mmjax
012353   STOCK Hprttm65(Ple53-lacZ)Ems/Mmjax
012354   STOCK Hprttm66(Ple5-lacZ)Ems/Mmjax
012584   STOCK Hprttm69(Ple134-lacZ)Ems/Mmjax
012923   STOCK IppkGt(XA232)Byg/J
006578   STOCK Myoz2tm1Eno/J
005707   STOCK Rag1tm1Mom Tg(TIE2-lacZ)182Sato/J
006882   STOCK Tg(CAG-Bgeo,-AML1/ETO,-ALPP)1Lbe/J
005438   STOCK Tg(CAG-Bgeo,-DsRed*MST)1Nagy/J
006850   STOCK Tg(CAG-Bgeo,-NOTCH1,-EGFP)1Lbe/J
006876   STOCK Tg(CAG-Bgeo,-TEL/AML1,-EGFP)A6Lbe/J
006613   STOCK Tg(CAG-Bgeo,-Tle1,-ALPP)1Lbe/J
003919   STOCK Tg(CAG-Bgeo/ALPP)1Lbe/J
003920   STOCK Tg(CAG-Bgeo/GFP)21Lbe/J
006674   STOCK Tg(Olfr16,taulacZ)2030Mom/MomJ
008477   STOCK Tg(RARE-Hspa1b/lacZ)12Jrt/J
008203   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(ACTA1-SMN)63Ahmb/J
006553   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(H2-K1-tsA58)6Kio Tg(SMN2*delta7)4299Ahmb/J
008212   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(Prnp-SMN)92Ahmb/J
004623   STOCK Tg(TCF/Lef1-lacZ)34Efu/J
005493   STOCK Tg(Tek-rtTA,TRE-lacZ)1425Tpr/J
002395   STOCK Tg(Zfy1-lacZ)218Bri/J
003274   STOCK Tg(tetNZL)2Bjd/J
005728   STOCK Tg(tetO-Ipf1,lacZ)958.1Macd/J
View lacZ Expression Strains     (257 strains)

Strains carrying other alleles of Npy
008321   B6.Cg-Tg(Npy-MAPT/Sapphire)1Rck/J
006417   B6.FVB-Tg(Npy-hrGFP)1Lowl/J
007585   B6;129S4-Npytm2Rpa/J
View Strains carrying other alleles of Npy     (3 strains)

Strains carrying other alleles of lacZ
002484   129-Alpltm1Sor/J
002292   129-Gt(ROSA)26Sor/J
006050   129-Sirt6tm1Fwa/J
003451   129-Smad3tm1Par/J
003310   129S-Gt(ROSA)26Sortm1Sor/J
003383   129S-Nogtm1Amc/J
005091   129S-Pnpla6tm1Blw/J
007199   129S-Sgpl1Gt(ROSA)78Sor/J
003082   129S1/SvImJ-Bcl2tm1Mpin/J
010633   B6(Cg)-Gt(ROSA)26Sortm1(CAG-taulacZ)Bene/J
023757   B6(Cg)-Tg(tetO-tetX,lacZ)1Gogo/UmriJ
005085   B6.129(Cg)-Cd44tm1Hbg/J
012239   B6.129(Cg)-Cd44tm1Hbg/SjJ
004178   B6.129(Cg)-Tg(CAG-Bgeo/GFP)21Lbe/J
004478   B6.129-Foxd1tm1Lai/J
006939   B6.129-Fut1tm1Sdo/J
005768   B6.129-Htr5atm1Dgen/J
002938   B6.129-Kdrtm1Jrt/J
004158   B6.129-Maftm1Gsb/J
008233   B6.129-Nrgntm1Kph/J
006497   B6.129-Skiltm2Spw/J
005849   B6.129-Tmprss11atm1Dgen/J
009348   B6.129P2(Cg)-Hprttm17(Ple48-lacZ)Ems/Mmjax
012572   B6.129P2(Cg)-Hprttm19(Ple88-lacZ)Ems/Mmjax
012574   B6.129P2(Cg)-Hprttm38(Ple17-lacZ)Ems/Mmjax
012575   B6.129P2(Cg)-Hprttm39(Ple24-lacZ)Ems/Mmjax
012576   B6.129P2(Cg)-Hprttm40(Ple34-lacZ)Ems/Mmjax
010805   B6.129P2(Cg)-Hprttm41(Ple160-lacZ)Ems/Mmjax
012331   B6.129P2(Cg)-Hprttm42(Ple131-lacZ)Ems/Mmjax
012577   B6.129P2(Cg)-Hprttm43(Ple140-lacZ)Ems/Mmjax
010709   B6.129P2(Cg)-Hprttm44(Ple49-lacZ)Ems/Mmjax
012333   B6.129P2(Cg)-Hprttm45(Ple67-lacZ)Ems/Mmjax
012733   B6.129P2(Cg)-Hprttm53(CAG-lacZ)Ems/Mmjax
012578   B6.129P2(Cg)-Hprttm56(Ple25-lacZ)Ems/Mmjax
012579   B6.129P2(Cg)-Hprttm58(Ple119-lacZ)Ems/Mmjax
012580   B6.129P2(Cg)-Hprttm59(Ple123-lacZ)Ems/Mmjax
012581   B6.129P2(Cg)-Hprttm62(Ple153-lacZ)Ems/Mmjax
012342   B6.129P2(Cg)-Hprttm63(Ple12-lacZ)Ems/Mmjax
012347   B6.129P2(Cg)-Hprttm64(Ple170-lacZ)Ems/Mmjax
012582   B6.129P2(Cg)-Hprttm67(Ple238-lacZ)Ems/Mmjax
012583   B6.129P2(Cg)-Hprttm68(Ple127-lacZ)Ems/Mmjax
012656   B6.129P2(Cg)-Hprttm70(Ple240-lacZ)Ems/Mmjax
012657   B6.129P2(Cg)-Hprttm71(Ple155-lacZ)Ems/Mmjax
012659   B6.129P2(Cg)-Hprttm73(Ple142-lacZ)Ems/Mmjax
012734   B6.129P2(Cg)-Hprttm74(Ple232-lacZ)Ems/Mmjax
010921   B6.129P2(Cg)-Smn1tm1Msd/J
008235   B6.129P2-Abcg5tm1Plo/J
005772   B6.129P2-Acvrl1tm1Dgen/J
005770   B6.129P2-Adamts4tm1Dgen/J
005771   B6.129P2-Adamts5tm1Dgen/J
005773   B6.129P2-Adcy3tm1Dgen/J
005774   B6.129P2-Adcy7tm1Dgen/J
005775   B6.129P2-Adipor2tm1Dgen/J
005776   B6.129P2-Avpr1atm1Dgen/J
009120   B6.129P2-Axin2tm1Wbm/J
005777   B6.129P2-Axltm1Dgen/J
005783   B6.129P2-Cacna1ctm1Dgen/J
005780   B6.129P2-Cacna2d3tm1Dgen/J
005781   B6.129P2-Cacng3tm1Dgen/J
005782   B6.129P2-Cacng4tm1Dgen/J
005784   B6.129P2-Capn5tm1Dgen/J
005785   B6.129P2-Capn7tm1Dgen/J
005792   B6.129P2-Ccr1l1tm1Dgen/J
005793   B6.129P2-Ccr6tm1Dgen/J
005794   B6.129P2-Ccr7tm1Dgen/J
005779   B6.129P2-Celsr2tm1Dgen/J
005797   B6.129P2-Chrna2tm1Dgen/J
007566   B6.129P2-Clip2tm1.1Gal/J
005787   B6.129P2-Ctsctm1Dgen/J
005796   B6.129P2-Cxcr3tm1Dgen/J
005798   B6.129P2-Drd5tm1Dgen/J
005800   B6.129P2-Efemp2tm1Dgen/J
005801   B6.129P2-Esrratm1Dgen/J
005802   B6.129P2-Faim2tm1Dgen/J
005803   B6.129P2-Fzd1tm1Dgen/J
005804   B6.129P2-Fzd8tm1Dgen/J
005811   B6.129P2-Gabra3tm1Dgen/J
005812   B6.129P2-Gabra4tm1Dgen/J
005810   B6.129P2-Gabrptm1Dgen/J
005809   B6.129P2-Galr1tm1Dgen/J
005816   B6.129P2-Glra3tm1Dgen/J
005805   B6.129P2-Gpr151tm1Dgen/J
005806   B6.129P2-Gpr37tm1Dgen/J
005807   B6.129P2-Gpr6tm1Dgen/J
005813   B6.129P2-Grik5tm1Dgen/J
005808   B6.129P2-Grk5tm1Dgen/J
005814   B6.129P2-Grm1tm1Dgen/J
005815   B6.129P2-Grm3tm1Dgen/J
005817   B6.129P2-Gsk3btm1Dgen/J
005818   B6.129P2-Hcrtr1tm1Dgen/J
005767   B6.129P2-Htr4tm1Dgen/J
005769   B6.129P2-Htr7tm1Dgen/J
005821   B6.129P2-Lats2tm1Dgen/J
005822   B6.129P2-Lmbr1tm1Dgen/J
005850   B6.129P2-Mapkapk2tm1Dgen/J
005824   B6.129P2-Mmp17tm1Dgen/J
005825   B6.129P2-Mtmr1tm1Dgen/J
005826   B6.129P2-Ntsr1tm1Dgen/J
005829   B6.129P2-Pkd2l2tm1Dgen/J
005828   B6.129P2-Ppardtm1Dgen/J
005831   B6.129P2-Ppm1ftm1Dgen/J
005827   B6.129P2-Ptch2tm1Dgen/J
005832   B6.129P2-Ptprotm1Dgen/J
005799   B6.129P2-S1pr4tm1Dgen/J
005837   B6.129P2-Scn11atm1Dgen/J
005836   B6.129P2-Scn9atm1Dgen/J
005834   B6.129P2-Sema5atm1Dgen/J
005835   B6.129P2-Sema6ctm1Dgen/J
006432   B6.129P2-Slc18a1tm1Dgen/J
005839   B6.129P2-Slc22a12tm1Dgen/J
005838   B6.129P2-Slc22a6tm1Dgen/J
005840   B6.129P2-Slc40a1tm1Dgen/J
005841   B6.129P2-Slc6a9tm1Dgen/J
005842   B6.129P2-Slc7a8tm1Dgen/J
005843   B6.129P2-Slc9a6tm1Dgen/J
005844   B6.129P2-Sstr1tm1Dgen/J
005847   B6.129P2-Tgfbr1tm1Dgen/J
005845   B6.129P2-Thbs4tm1Dgen/J
005790   B6.129P2-Tpp1tm1Dgen/J
005848   B6.129P2-Trpm5tm1Dgen/J
005791   B6.129P2-Xcr1tm1Dgen/J
012377   B6.129S-Cyp19a1tm1.1Shah/J
009089   B6.129S1(Cg)-Ndntm2Stw/J
009387   B6.129S1-Osr1tm1Jian/J
009386   B6.129S1-Osr2tm1Jian/J
010617   B6.129S1-Snai2tm1Grid/J
003474   B6.129S4-Gt(ROSA)26Sortm1Sor/J
006142   B6.129S4-Ppargtm1Rev/J
003754   B6.129S4-Shroom3Gt(ROSA53)Sor/J
005119   B6.129S6-Npas2tm1Slm/J
002741   B6.129S7-Alpltm1Sor/J
005970   B6.129S7-Atoh1tm2Hzo/J
006039   B6.129S7-Efnb2tm1And/J
002192   B6.129S7-Gt(ROSA)26Sor/J
005981   B6.129S7-Rai1tm1Jrl/J
005039   B6.129X1-Adra1atm1Pcs/J
006262   B6.129X1-Fut2tm1Sdo/J
025101   B6.Cg-Avpr1atm1Dgen Tg(AVPR1A)1Bux/BuxJ
014536   B6.Cg-Hprttm75(Ple143-lacZ)Ems/Mmjax
007745   B6.Cg-Mir155tm1.1Rsky/J
005317   B6.Cg-Tg(BAT-lacZ)3Picc/J
003139   B6.Cg-Tg(DBHn-lacZ)8Rpk/J
006229   B6.Cg-Tg(DRE-lacZ)2Gswz/J
024050   B6.Cg-Tg(Hmgcr-lacZ)H253Sest/J
008629   B6.Cg-Tg(SMN2)11Tro Smn1tm1Msd/J
008631   B6.Cg-Tg(SMN2)11Tro Tg(SMN2)46Tro Smn1tm1Msd/J
008630   B6.Cg-Tg(SMN2)46Tro Smn1tm1Msd/J
007222   B6.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN1*A2G)2023Ahmb/J
006964   B6.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
006773   B6.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd/J
024377   B6.Cg-Tg(TCF/Lef1-lacZ)34Efu/KatmJ
009136   B6.Cg-Tg(tetO-Kcnj2,lacZ)1Gogo/J
002982   B6.Cg-Tg(xstpx-lacZ)32And/J
018625   B6.FVB-Tg(Fabp4-lacZ)4Mosh/J
008615   B6;129-Frzbtm1Nat/J
008621   B6;129-Fzd5tm1Nat/J
016857   B6;129-Itga7tm1Burk/J
005064   B6;129-Slc30a3tm1Rpa/J
009599   B6;129P2-Adam19Gt(Betageo)1Bbl/J
006431   B6;129P2-Adam21tm1Dgen/J
005788   B6;129P2-Cd97tm1Dgen/J
008590   B6;129P2-Cxcl14tm1Litt/J
006703   B6;129P2-Gucy2dtm1Mom/MomJ
021162   B6;129P2-Mapttm2Arbr/J
006665   B6;129P2-Olfr151tm13(rI7)Mom/MomJ
006666   B6;129P2-Olfr151tm24(Olfr2)Mom/MomJ
005833   B6;129P2-Rgs4tm1Dgen/J
002073   B6;129S-Gt(ROSA)26Sor/J
006470   B6;129S-Hopxtm1Eno/J
004153   B6;129S-Map7Gt(ROSABetageo)1Sor/J
006958   B6;129S-Nkd1tm1Kwha/J
006960   B6;129S-Nkd2tm1Kwha/J
010619   B6;129S1-Lfngtm1Grid/J
007208   B6;129S4-Csrnp1Gt(ROSA)80Sor/J
011052   B6;129S4-Ctbp2Gt(ROSA61)Sor/J
003309   B6;129S4-Gt(ROSA)26Sortm1Sor/J
007207   B6;129S4-Zfp640Gt(ROSA)81Sor/J
004365   B6;129S6-Srebf1tm1Mbr/J
002317   B6;129S7-Alpltm1Sor/J
003266   B6;129S7-Epas1tm1Rus/J
006044   B6;129S7-Ephb4tm1And/J
012436   B6;129S7-Tg(CAG-lacZ,-BMPR1A*,-EGFP)1Mis/Mmjax
008618   B6;A-Tg(OPN1LW-lacZ)1Nat/J
006465   B6;CBA-Tg(CAG-lacZ-WGA)330Bbm/J
007975   B6;CBA-Tg(OR8A1-taulacZ)1Mom/MomJ
007972   B6;CBA-Tg(Olfr151-taulacZ)4Mom/MomJ
006680   B6;CBA-Tg(Olfr16*,taulacZ)19Mom/MomJ
006671   B6;CBA-Tg(Olfr16*,taulacZ)5Mom/MomJ
006672   B6;CBA-Tg(Olfr16*,taulacZ)7Mom/MomJ
006673   B6;CBA-Tg(Olfr16,taulacZ)sn2Mom/MomJ
007973   B6;CBA-Tg(Olfr16-taulacZ)1Mom/MomJ
007974   B6;CBA-Tg(Olfr160-taulacZ)V4-7Mom/MomJ
007976   B6;CBA-Tg(Olfr713-taulacZ)4Mom/MomJ
006743   B6;CBA-Tg(P-taulacZ)11Mom/MomJ
006793   B6;CBA-Tg(P-taulacZ)13Mom/MomJ
006742   B6;CBA-Tg(P-taulacZ)8Mom/MomJ
004141   B6;CBA-Tg(UAS-lacZ)65Rth/J
008344   B6;DBA-Tg(Fos-tTA,Fos-EGFP*)1Mmay Tg(tetO-lacZ,tTA*)1Mmay/J
018627   B6;SJL-Tg(Myl1-lacZ)1Ibdml/J
026216   B6;SJL-Tg(Tnnt2-lacZ)497Jl/J
002369   B6;SJL-Tg(c177-lacZ)226Bri/J
002372   B6;SJL-Tg(c177-lacZ)227Bri/J
002621   B6;SJL-Tg(tetop-lacZ)2Mam/J
003299   B6;SWJ-Tg(TIMP3-lacZ)7Jeb/J
002865   B6CBA-Tg(Wnt1-lacZ)206Amc/J
019101   B6N.129S4(B6)-Gt(ROSA)26Sortm1Sor/CjDswJ
018913   B6N.Cg-Tg(tetO-GFP,-lacZ)G3Rsp/J
002955   C.129S7-Gt(ROSA)26Sor/J
009062   C57BL/6-Magel2tm1Stw/J
017955   C57BL/6-Tg(Gfap-rtTA,tetO-MAOB,-lacZ)1Jkan/J
002754   C57BL/6-Tg(LacZpl)60Vij/J
013729   C57BL/6-Tg(tetO-EDN1,-lacZ)9Mhus/J
013728   C57BL/6-Tg(tetO-NOS2,-lacZ)240iMhus/J
002193   C57BL/6J-Tg(MTn-lacZ)204Bri/J
005420   C;129S7 Gt(ROSA)26Sor-Bmp5cfe-se7J/GrsrJ
002981   DBA/2-Tg(xstpx-lacZ)36And/J
017333   FVB-Tg(tetO-Gnai2*,-lacZ)382Kndl/J
007225   FVB.129(B6)-Usp18tm1Dzh/J
006214   FVB.129P2-Smn1tm1Msd/J
009427   FVB.129S4(B6)-Gt(ROSA)26Sortm1Sor/J
012429   FVB.Cg-Gt(ROSA)26Sortm1(CAG-lacZ,-EGFP)Glh/J
008206   FVB.Cg-Smn1tm1Msd Tg(SMN2)566Ahmb/J
008209   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(ACTA1-SMN)69Ahmb/J
016573   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(S100B-EGFP)1Wjt Tg(SMN2*delta7)4299Ahmb/J
007968   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN1*A2G)2023Ahmb/2J
008782   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*A111G)588Ahmb/J
009134   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*A111G)591Ahmb/J
007952   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/2J
005025   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
005026   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN1*A2G)2023Ahmb/J
007949   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd/2J
005024   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd/J
003487   FVB.Cg-Tg(XGFAP-lacZ)3Mes/J
003140   FVB/N-Tg(PAI1-lacZ)1Jjb/J
002856   FVB/N-Tg(TIE2-lacZ)182Sato/J
005941   FVB/N-Tg(tetO-Aurkb,lacZ)41Kra/J
003315   FVB/N-Tg(tetORo1-lacZ)3Conk/J
005878   NOD.129(Cg)-Cd44tm1Hbg/J
003899   STOCK Cd44tm1Hbg/J
008602   STOCK Cdontm2Rsk/J
007912   STOCK En1tm2Alj/J
007925   STOCK En2tm5.1Alj/J
008211   STOCK Gli1tm2Alj/J
007922   STOCK Gli2tm2.1Alj/J
017596   STOCK Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb Tg(tetO-SMN2,-luc)#aAhmb/J
017597   STOCK Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb Tg(tetO-SMN2,-luc)#bAhmb/J
024746   STOCK Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy Hprttm1(tetO-Dkk1)Spdl Tg(TCF/Lef1-lacZ)34Efu/J
006241   STOCK Hhiptm1Amc/J
010707   STOCK Hprttm37(lacZ)Ems/Mmjax
012335   STOCK Hprttm50(Ple55-lacZ)Ems/Mmjax
013764   STOCK Hprttm57(Ple26-lacZ)Ems/Mmjax
012353   STOCK Hprttm65(Ple53-lacZ)Ems/Mmjax
012354   STOCK Hprttm66(Ple5-lacZ)Ems/Mmjax
012584   STOCK Hprttm69(Ple134-lacZ)Ems/Mmjax
007022   STOCK Mnx1tm4(cre)Tmj Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
006578   STOCK Myoz2tm1Eno/J
006646   STOCK Olfr151tm11(Olfr160)Mom/MomJ
006645   STOCK Olfr151tm12(Olfr16)Mom/MomJ
006691   STOCK Olfr151tm14(Adrb2)Mom/MomJ
006635   STOCK Olfr151tm15(V1rb2)Mom/MomJ
006630   STOCK Olfr151tm1Mom/MomJ
006629   STOCK Olfr151tm2Mom/MomJ
006628   STOCK Olfr151tm3Mom/MomJ
006740   STOCK Olfr160tm1(Olfr151)Mom Tg(Olfr151,taulacZ)AMom/MomJ
006741   STOCK Olfr160tm1(Olfr151)Mom Tg(Olfr151,taulacZ)BMom/MomJ
006651   STOCK Olfr17tm4Mom/MomJ
005707   STOCK Rag1tm1Mom Tg(TIE2-lacZ)182Sato/J
006633   STOCK Vmn1r49tm3Mom/MomJ
006634   STOCK Vmn1r49tm4(Olfr151)Mom/MomJ
014092   STOCK Tg(ACTB-tTA2,-MAPT/lacZ)1Luo/J
006613   STOCK Tg(CAG-Bgeo,-Tle1,-ALPP)1Lbe/J
003920   STOCK Tg(CAG-Bgeo/GFP)21Lbe/J
006674   STOCK Tg(Olfr16,taulacZ)2030Mom/MomJ
008477   STOCK Tg(RARE-Hspa1b/lacZ)12Jrt/J
008203   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(ACTA1-SMN)63Ahmb/J
006553   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(H2-K1-tsA58)6Kio Tg(SMN2*delta7)4299Ahmb/J
006570   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(Hlxb9-GFP)1Tmj/J
008212   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(Prnp-SMN)92Ahmb/J
018916   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN1-SMN2*)16Cll/CllJ
004623   STOCK Tg(TCF/Lef1-lacZ)34Efu/J
005493   STOCK Tg(Tek-rtTA,TRE-lacZ)1425Tpr/J
002395   STOCK Tg(Zfy1-lacZ)218Bri/J
003274   STOCK Tg(tetNZL)2Bjd/J
005728   STOCK Tg(tetO-Ipf1,lacZ)958.1Macd/J
View Strains carrying other alleles of lacZ     (284 strains)

Additional Web Information

Fluorescent Proteins/lacZ Systems

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Npytm1Rpa/Npytm1Rpa

        involves: 129S7/SvEvBrd
  • behavior/neurological phenotype
  • increased susceptibility to pharmacologically induced seizures
    • pentylenetrazole (PTZ) treatment at 50 or 60 mg/kg induced convulsions in 80% of mutant mice compared to 33% of controls   (MGI Ref ID J:33261)
    • convulsions in the mutant mice were also scored as more severe   (MGI Ref ID J:33261)
  • sporadic seizures
    • mice exhibited occasional mild seizures at 6-8 weeks of age, with decreased frequency until 9 weeks and were not seen thereafter; seizures consisted of jerking of the head and body, tail extension and vocalization   (MGI Ref ID J:33261)
  • homeostasis/metabolism phenotype
  • *normal* homeostasis/metabolism phenotype
    • no defects were observed in food intake, body weight and adiposity   (MGI Ref ID J:33261)
    • normal glucose homeostasis was also noted   (MGI Ref ID J:33261)
    • responses to food deprivation was similar to controls   (MGI Ref ID J:33261)
  • nervous system phenotype
  • increased susceptibility to pharmacologically induced seizures
    • pentylenetrazole (PTZ) treatment at 50 or 60 mg/kg induced convulsions in 80% of mutant mice compared to 33% of controls   (MGI Ref ID J:33261)
    • convulsions in the mutant mice were also scored as more severe   (MGI Ref ID J:33261)
  • sporadic seizures
    • mice exhibited occasional mild seizures at 6-8 weeks of age, with decreased frequency until 9 weeks and were not seen thereafter; seizures consisted of jerking of the head and body, tail extension and vocalization   (MGI Ref ID J:33261)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Diabetes and Obesity Research
Obesity Without Diabetes
      leptin hypersensitive

Neurobiology Research
lacZ expression in neural tissue
Channel and Transporter Defects

Research Tools
lacZ Expression
Diabetes and Obesity Research
      lacZ

Npytm1Rpa related

Diabetes and Obesity Research
Obesity Without Diabetes
      leptin hypersensitive

Neurobiology Research
Epilepsy

Research Tools
Neurobiology Research
      cell marker

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Npytm1Rpa
Allele Name targeted mutation 1, Richard D Palmiter
Allele Type Targeted (Null/Knockout, Reporter)
Common Name(s) Npy-;
Mutation Made ByDr. Richard Palmiter,   University of Washington
Strain of Origin129S7/SvEvBrd-Hprt<+>
ES Cell Line NameAB1
ES Cell Line Strain129S7/SvEvBrd-Hprt<+>
Site of ExpressionlacZ replaces/mimics endogenous gene expression
Expressed Gene lacZ, beta-galactosidase, E. coli
Molecular Note Exon 2, which encodes the signal peptide and 35 amino acids, was replaced by a lacZ-neo fusion gene. The expression pattern of the beta-galactosidase was shown to resemble that of the endogenous gene via comparisons of X-gal staining and previous in situhybridization studies. RT-PCR analysis of brain tissue showed an absence of transcript in homozygous mutant mice. [MGI Ref ID J:33261]
 
Gene Symbol and Name Npy, neuropeptide Y
Chromosome 6
Gene Common Name(s) 0710005A05Rik; NPY02; PYY4; RATNPY; RATNPY02; RIKEN cDNA 0710005A05 gene;

Genotyping

Genotyping Information

Genotyping Protocols

Npytm1Rpa, Separated PCR
Npytm1Rpa, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Erickson JC; Clegg KE; Palmiter RD. 1996. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y [see comments] Nature 381(6581):415-21. [PubMed: 8632796]  [MGI Ref ID J:33261]

Additional References

Npytm1Rpa related

Anitha M; Chandrasekharan B; Salgado JR; Grouzmann E; Mwangi S; Sitaraman SV; Srinivasan S. 2006. Glial-derived neurotrophic factor modulates enteric neuronal survival and proliferation through neuropeptide Y. Gastroenterology 131(4):1164-78. [PubMed: 17030186]  [MGI Ref ID J:124956]

Atasoy D; Betley JN; Su HH; Sternson SM. 2012. Deconstruction of a neural circuit for hunger. Nature 488(7410):172-7. [PubMed: 22801496]  [MGI Ref ID J:186689]

Bannon AW; Seda J; Carmouche M; Francis JM; Norman MH; Karbon B; McCaleb ML. 2000. Behavioral characterization of neuropeptide Y knockout mice Brain Res 868(1):79-87. [PubMed: 10841890]  [MGI Ref ID J:62886]

Baraban SC; Hollopeter G; Erickson JC; Schwartzkroin PA; Palmiter RD. 1997. Knock-out mice reveal a critical antiepileptic role for neuropeptide Y. J Neurosci 17(23):8927-36. [PubMed: 9364040]  [MGI Ref ID J:44284]

Baskin DG; Seeley RJ; Kuijper JL; Lok S; Weigle DS; Erickson JC; Palmiter RD; Schwartz MW. 1998. Increased expression of mRNA for the long form of the leptin receptor in the hypothalamus is associated with leptin hypersensitivity and fasting. Diabetes 47(4):538-43. [PubMed: 9568684]  [MGI Ref ID J:46631]

Chandrasekharan B; Bala V; Kolachala VL; Vijay-Kumar M; Jones D; Gewirtz AT; Sitaraman SV; Srinivasan S. 2008. Targeted deletion of neuropeptide Y (NPY) modulates experimental colitis. PLoS ONE 3(10):e3304. [PubMed: 18836554]  [MGI Ref ID J:144421]

Chen HY; Trumbauer ME; Chen AS; Weingarth DT; Adams JR; Frazier EG; Shen Z; Marsh DJ; Feighner SD; Guan XM; Ye Z; Nargund RP; Smith RG; Van der Ploeg LH; Howard AD; MacNeil DJ; Qian S. 2004. Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein. Endocrinology 145(6):2607-12. [PubMed: 14962995]  [MGI Ref ID J:90744]

Chiba T; Tamashiro Y; Park D; Kusudo T; Fujie R; Komatsu T; Kim SE; Park S; Hayashi H; Mori R; Yamashita H; Chung HY; Shimokawa I. 2014. A key role for neuropeptide Y in lifespan extension and cancer suppression via dietary restriction. Sci Rep 4:4517. [PubMed: 24682105]  [MGI Ref ID J:210447]

De Jonghe BC; Hayes MR; Zimmer DJ; Kanoski SE; Grill HJ; Bence KK. 2012. Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency. Am J Physiol Endocrinol Metab 303(5):E644-51. [PubMed: 22761160]  [MGI Ref ID J:189527]

Doyle KL; Karl T; Hort Y; Duffy L; Shine J; Herzog H. 2008. Y1 receptors are critical for the proliferation of adult mouse precursor cells in the olfactory neuroepithelium. J Neurochem 105(3):641-52. [PubMed: 18088353]  [MGI Ref ID J:134462]

Elefteriou F; Takeda S; Liu X; Armstrong D; Karsenty G. 2003. Monosodium glutamate-sensitive hypothalamic neurons contribute to the control of bone mass. Endocrinology 144(9):3842-7. [PubMed: 12933656]  [MGI Ref ID J:85588]

Erickson JC; Hollopeter G; Palmiter RD. 1996. Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science 274(5293):1704-7. [PubMed: 8939859]  [MGI Ref ID J:37106]

Gehlert DR; Shaw JL. 2007. Increased brain neuropeptide Y1 and Y2 receptor binding in NPY knock out mice does not result in increased receptor function. Peptides 28(2):241-9. [PubMed: 17208335]  [MGI Ref ID J:124440]

Goncalves GH; Li W; Garcia AV; Figueiredo MS; Bjorbaek C. 2014. Hypothalamic agouti-related peptide neurons and the central melanocortin system are crucial mediators of leptin's antidiabetic actions. Cell Rep 7(4):1093-103. [PubMed: 24813890]  [MGI Ref ID J:211797]

Guan XM; Chen H; Dobbelaar PH; Dong Y; Fong TM; Gagen K; Gorski J; He S; Howard AD; Jian T; Jiang M; Kan Y; Kelly TM; Kosinski J; Lin LS; Liu J; Marsh DJ; Metzger JM; Miller R; Nargund RP; Palyha O; Shearman L; Shen Z; Stearns R; Strack AM; Stribling S; Tang YS; Wang SP; White A; Yu H; Reitman ML. 2010. Regulation of energy homeostasis by bombesin receptor subtype-3: selective receptor agonists for the treatment of obesity. Cell Metab 11(2):101-12. [PubMed: 20096642]  [MGI Ref ID J:158348]

Hansel DE; Eipper BA; Ronnett GV. 2001. Neuropeptide Y functions as a neuroproliferative factor. Nature 410(6831):940-4. [PubMed: 11309620]  [MGI Ref ID J:68917]

Harrington M; Molyneux P; Soscia S; Prabakar C; McKinley-Brewer J; Lall G. 2007. Behavioral and neurochemical sources of variability of circadian period and phase: studies of circadian rhythms of npy-/- mice. Am J Physiol Regul Integr Comp Physiol 292(3):R1306-14. [PubMed: 17082354]  [MGI Ref ID J:119102]

Hill JW; Levine JE. 2003. Abnormal response of the neuropeptide Y-deficient mouse reproductive axis to food deprivation but not lactation. Endocrinology 144(5):1780-6. [PubMed: 12697683]  [MGI Ref ID J:115711]

Hohmann JG; Teklemichael DN; Weinshenker D; Wynick D; Clifton DK; Steiner RA. 2004. Obesity and endocrine dysfunction in mice with deletions of both neuropeptide Y and galanin. Mol Cell Biol 24(7):2978-85. [PubMed: 15024085]  [MGI Ref ID J:89070]

Hollopeter G; Erickson JC; Palmiter RD. 1998. Role of neuropeptide Y in diet-, chemical- and genetic-induced obesity of mice. Int J Obes Relat Metab Disord 22(6):506-12. [PubMed: 9665670]  [MGI Ref ID J:49932]

Kim HJ; Harrington ME. 2008. Neuropeptide Y-deficient mice show altered circadian response to simulated natural photoperiod. Brain Res 1246:96-100. [PubMed: 18926801]  [MGI Ref ID J:147619]

Krashes MJ; Shah BP; Koda S; Lowell BB. 2013. Rapid versus delayed stimulation of feeding by the endogenously released AgRP neuron mediators GABA, NPY, and AgRP. Cell Metab 18(4):588-95. [PubMed: 24093681]  [MGI Ref ID J:206003]

Laskowski A; Howell OW; Sosuov AA; McKhann G; Gray WP. 2007. NPY mediates basal and seizure-induced proliferation in the subcallosal zone. Neuroreport 18(10):1005-8. [PubMed: 17558285]  [MGI Ref ID J:123746]

Luque RM; Kineman RD; Tena-Sempere M. 2007. Regulation of hypothalamic expression of KiSS-1 and GPR54 genes by metabolic factors: analyses using mouse models and a cell line. Endocrinology 148(10):4601-11. [PubMed: 17595226]  [MGI Ref ID J:129475]

Luque RM; Park S; Kineman RD. 2007. Severity of the catabolic condition differentially modulates hypothalamic expression of growth hormone-releasing hormone in the fasted mouse: potential role of neuropeptide Y and corticotropin-releasing hormone. Endocrinology 148(1):300-9. [PubMed: 17038558]  [MGI Ref ID J:129559]

Minor RK; Villarreal J; McGraw M; Percival SS; Ingram DK; de Cabo R. 2008. Calorie restriction alters physical performance but not cognition in two models of altered neuroendocrine signaling. Behav Brain Res 189(1):202-211. [PubMed: 18291538]  [MGI Ref ID J:132779]

Park S; Peng XD; Frohman LA; Kineman RD. 2005. Expression analysis of hypothalamic and pituitary components of the growth hormone axis in fasted and streptozotocin-treated neuropeptide Y (NPY)-intact (NPY+/+) and NPY-knockout (NPY-/-) mice. Neuroendocrinology 81(6):360-71. [PubMed: 16244497]  [MGI Ref ID J:106620]

Patel HR; Qi Y; Hawkins EJ; Hileman SM; Elmquist JK; Imai Y; Ahima RS. 2006. Neuropeptide Y deficiency attenuates responses to fasting and high-fat diet in obesity-prone mice. Diabetes 55(11):3091-8. [PubMed: 17065347]  [MGI Ref ID J:116549]

Phillips CT; Palmiter RD. 2008. Role of agouti-related protein-expressing neurons in lactation. Endocrinology 149(2):544-50. [PubMed: 17974621]  [MGI Ref ID J:144616]

Protas L; Barbuti A; Qu J; Rybin VO; Palmiter RD; Steinberg SF; Robinson RB. 2003. Neuropeptide Y is an essential in vivo developmental regulator of cardiac ICa,L. Circ Res 93(10):972-9. [PubMed: 14525809]  [MGI Ref ID J:135474]

Qian S; Chen H; Weingarth D; Trumbauer ME; Novi DE; Guan X; Yu H; Shen Z; Feng Y; Frazier E; Chen A; Camacho RE; Shearman LP; Gopal-Truter S; MacNeil DJ; Van der Ploeg LH; Marsh DJ. 2002. Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice. Mol Cell Biol 22(14):5027-35. [PubMed: 12077332]  [MGI Ref ID J:78034]

Schwartz MW; Erickson JC; Baskin DG; Palmiter RD. 1998. Effect of fasting and leptin deficiency on hypothalamic neuropeptide Y gene transcription in vivo revealed by expression of a lacZ reporter gene. Endocrinology 139(5):2629-35. [PubMed: 9564880]  [MGI Ref ID J:114273]

Segal-Lieberman G; Trombly DJ; Juthani V; Wang X; Maratos-Flier E. 2003. NPY ablation in C57BL/6 mice leads to mild obesity and to an impaired refeeding response to fasting. Am J Physiol Endocrinol Metab 284(6):E1131-9. [PubMed: 12582011]  [MGI Ref ID J:83899]

Shannon HE; Yang L. 2004. Seizure susceptibility of neuropeptide-Y null mutant mice in amygdala kindling and chemical-induced seizure models. Epilepsy Res 61(1-3):49-62. [PubMed: 15451008]  [MGI Ref ID J:101832]

Shi TJ; Zhang X; Berge OG; Erickson JC; Palmiter RD; Hokfelt T. 1998. Effect of peripheral axotomy on dorsal root ganglion neuron phenotype and autonomy behaviour in neuropeptide Y-deficient mice. Regul Pept 75-76:161-73. [PubMed: 9802405]  [MGI Ref ID J:53172]

Sinclair JR; Jacobs AL; Nirenberg S. 2004. Selective ablation of a class of amacrine cells alters spatial processing in the retina. J Neurosci 24(6):1459-67. [PubMed: 14960619]  [MGI Ref ID J:109725]

Sindelar DK; Mystkowski P; Marsh DJ; Palmiter RD; Schwartz MW. 2002. Attenuation of diabetic hyperphagia in neuropeptide Y--deficient mice. Diabetes 51(3):778-83. [PubMed: 11872679]  [MGI Ref ID J:75023]

Sindelar DK; Palmiter RD; Woods SC; Schwartz MW. 2005. Attenuated feeding responses to circadian and palatability cues in mice lacking neuropeptide Y. Peptides 26(12):2597-602. [PubMed: 15923061]  [MGI Ref ID J:106644]

Sindelar DK; Ste Marie L; Miura GI; Palmiter RD; McMinn JE; Morton GJ; Schwartz MW. 2004. Neuropeptide Y is required for hyperphagic feeding in response to neuroglucopenia. Endocrinology 145(7):3363-8. [PubMed: 15064281]  [MGI Ref ID J:105627]

Singer K; Morris DL; Oatmen KE; Wang T; DelProposto J; Mergian T; Cho KW; Lumeng CN. 2013. Neuropeptide Y is produced by adipose tissue macrophages and regulates obesity-induced inflammation. PLoS One 8(3):e57929. [PubMed: 23472120]  [MGI Ref ID J:199848]

Solway B; Bose SC; Corder G; Donahue RR; Taylor BK. 2011. Tonic inhibition of chronic pain by neuropeptide Y. Proc Natl Acad Sci U S A 108(17):7224-9. [PubMed: 21482764]  [MGI Ref ID J:171345]

Sun QQ; Baraban SC; Prince DA; Huguenard JR. 2003. Target-specific neuropeptide Y-ergic synaptic inhibition and its network consequences within the mammalian thalamus. J Neurosci 23(29):9639-49. [PubMed: 14573544]  [MGI Ref ID J:86308]

Thiele TE; Marsh DJ; Ste. Marie L; Bernstein IL; Palmiter RD. 1998. Ethanol consumption and resistance are inversely related to neuropeptide Y levels [see comments] Nature 396(6709):366-9. [PubMed: 9845072]  [MGI Ref ID J:51243]

Thiele TE; Miura GI; Marsh DJ; Bernstein IL; Palmiter RD. 2000. Neurobiological responses to ethanol in mutant mice lacking neuropeptide Y or the Y5 receptor. Pharmacol Biochem Behav 67(4):683-91. [PubMed: 11166058]  [MGI Ref ID J:102529]

Tilan JU; Everhart LM; Abe K; Kuo-Bonde L; Chalothorn D; Kitlinska J; Burnett MS; Epstein SE; Faber JE; Zukowska Z. 2013. Platelet neuropeptide Y is critical for ischemic revascularization in mice. FASEB J 27(6):2244-55. [PubMed: 23457218]  [MGI Ref ID J:199958]

Tschop M; Statnick MA; Suter TM; Heiman ML. 2002. GH-releasing peptide-2 increases fat mass in mice lacking NPY: indication for a crucial mediating role of hypothalamic agouti-related protein. Endocrinology 143(2):558-68. [PubMed: 11796511]  [MGI Ref ID J:74978]

Vella KR; Ramadoss P; Lam FS; Harris JC; Ye FD; Same PD; O'Neill NF; Maratos-Flier E; Hollenberg AN. 2011. NPY and MC4R signaling regulate thyroid hormone levels during fasting through both central and peripheral pathways. Cell Metab 14(6):780-90. [PubMed: 22100407]  [MGI Ref ID J:179670]

Weinshenker D; Szot P; Miller NS; Rust NC; Hohmann JG; Pyati U; White SS; Palmiter RD. 2001. Genetic comparison of seizure control by norepinephrine and neuropeptide Y. J Neurosci 21(19):7764-9. [PubMed: 11567066]  [MGI Ref ID J:71685]

Xu M; Hill JW; Levine JE. 2000. Attenuation of luteinizing hormone surges in neuropeptide Y knockout mice Neuroendocrinology 72(5):263-71. [PubMed: 11124583]  [MGI Ref ID J:66273]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX11

Colony Maintenance

Breeding & HusbandryThe resulting chimeric animals were crossed to 129S1/SvImJ mice. This strain is maintained as a homozygote.
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $199.90Female or MaleHomozygous for Npytm1Rpa  
Price per Pair (US dollars $)Pair Genotype
$399.80Homozygous for Npytm1Rpa x Homozygous for Npytm1Rpa  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $259.90Female or MaleHomozygous for Npytm1Rpa  
Price per Pair (US dollars $)Pair Genotype
$519.80Homozygous for Npytm1Rpa x Homozygous for Npytm1Rpa  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

  Control
   002448 129S1/SvImJ (approximate)
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

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The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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