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| These Villin-Cre transgenic mice have Cre recombinase expression in intestinal epithelial cells of the villi and crypt cells of the small and large intestines. | |||||||||||||||||||
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Description
Strain Information
Former Names B6;SJL-Tg(Vil-cre)997Gum (Changed: 15-DEC-04 ) Type Congenic; Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Noncarrier x Hemizygote (Female x Male) 01-FEB-13 Mating System Hemizygote x Noncarrier (Female x Male) 01-FEB-13 Species laboratory mouse Generation N5+18 (22-SEP-09)
Generation DefinitionsDonating Investigator Deborah L. Gumucio, University of Michigan Description
Mice hemizygous for the Villin-cre transgene express Cre recombinase under the direction of the mouse villin 1 promoter. When crossed with a strain containing a loxP site-flanked sequence of interest, Cre-mediated recombination results in tissue-specific deletion of the target. Recombination occurs in villi and crypt cells of the small and large intestines, closely patterning the endogenous gene expression. The Donating Investigator indicates that expression is generally continuous, but that a small amount of mosaicism is noted in the colon. Onset of transgene expression is at 12.5 dpc, which is delayed from the endogenous mouse Vil1 gene expression onset of 9.0 dpc. The Donating Investigator reports that there is very low level <1% of cells with Cre recombinase activty in the testes. Hemizygous mutant mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. This mutant mouse strain may be useful in studies of intestinal organogenesis.View cre expression characterization.
Development
A transgenic construct containing the coding domain of Cre recombinase, driven by a 12.4 kb fragment of the mouse villin 1 gene, and a metallothionein polyadenylation site sequence was injected into the pronuclei of fertilized C57BL/6J x SJL/J mouse eggs. Founder animals were bred to C57BL/6 mice. The Villin-cre transgenic mice were then backcrossed to C57BL/6 mice for five generations.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of Vil1
017481 C57BL/6-Tg(Vil1-Myd88)1Lvh/J View Strains carrying other alleles of Vil1 (1 strain)
Additional Web Information
Introduction to Cre-lox technology
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
cre relatedResearch Tools
Cre-lox System
Cre Recombinase Expression
Developmental Biology Research
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Tg(Vil-cre)997Gum | ||
|---|---|---|---|
| Allele Name | transgene insertion 997, Deborah L Gumucio | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | 12.4KbVilCre; Tg(Vil-cre)997Gum; Vil-Cre; VilCre; Villin-cre; Villin.cre; VillinCre; | ||
| Mutation Made By | Blair Madison, University of Michigan | ||
| Strain of Origin | (C57BL/6J x SJL)F1 | ||
| Site of Expression | epithelial cells of the small and large intestines; onset of expression is at 12.5 d.p.c.; expression is generally continuous, but a small amount of mosaicism is noted in the colon | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | Vil1, villin 1, mouse, laboratory | ||
| Gene Symbol and Name | Tg(Vil-cre)997Gum, transgene insertion 997, Deborah L Gumucio | ||
| Chromosome | UN | ||
| Gene Common Name(s) | 12.4KbVilCre; Tg(Vil-cre)997Gum; Villin-cre; Villin.cre; VillinCre; | ||
| Driver Note | Vil1 | ||
| General Note | Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. | ||
| Molecular Note | A 12.4-kb promoter fragment from the villin 1 gene drives the expression of cre recombinase. Recombination occurs in villi and crypt cells of the small and large intestines, closely patterning the endogenous gene expression. According to the corresponding author (J:78815), expression is generally continuous but a small amount of mosaicism is noted in the colon. Onset of transgene expression is at 12.5 dpc, which is delayed from the endogenous mouse Vil gene expression onset of 9.0 dpc. [MGI Ref ID J:78815] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Tg(Vil-cre)997Gum, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Madison BB; Dunbar L; Qiao XT; Braunstein K; Braunstein E; Gumucio DL. 2002. cis Elements of the Villin Gene Control Expression in Restricted Domains of the Vertical (Crypt) and Horizontal (Duodenum, Cecum) Axes of the Intestine. J Biol Chem 277(36):33275-83. [PubMed: 12065599] [MGI Ref ID J:78815]
Additional References
Tg(Vil-cre)997Gum relatedAbles GP; Yang KJ; Vogel S; Hernandez-Ono A; Yu S; Yuen JJ; Birtles S; Buckett LK; Turnbull AV; Goldberg IJ; Blaner WS; Huang LS; Ginsberg HN. 2012. Intestinal DGAT1 deficiency reduces postprandial triglyceride and retinyl ester excursions by inhibiting chylomicron secretion and delaying gastric emptying. J Lipid Res 53(11):2364-79. [PubMed: 22911105] [MGI Ref ID J:190561]
Allaire JM; Darsigny M; Marcoux SS; Roy SA; Schmouth JF; Umans L; Zwijsen A; Boudreau F; Perreault N. 2011. Loss of Smad5 leads to the disassembly of the apical junctional complex and increased susceptibility to experimental colitis. Am J Physiol Gastrointest Liver Physiol 300(4):G586-97. [PubMed: 21212325] [MGI Ref ID J:171163]
Auclair BA; Benoit YD; Rivard N; Mishina Y; Perreault N. 2007. Bone morphogenetic protein signaling is essential for terminal differentiation of the intestinal secretory cell lineage. Gastroenterology 133(3):887-96. [PubMed: 17678919] [MGI Ref ID J:128279]
Babeu JP; Darsigny M; Lussier CR; Boudreau F. 2009. Hepatocyte nuclear factor 4alpha contributes to an intestinal epithelial phenotype in vitro and plays a partial role in mouse intestinal epithelium differentiation. Am J Physiol Gastrointest Liver Physiol 297(1):G124-34. [PubMed: 19389805] [MGI Ref ID J:151206]
Barry ER; Morikawa T; Butler BL; Shrestha K; de la Rosa R; Yan KS; Fuchs CS; Magness ST; Smits R; Ogino S; Kuo CJ; Camargo FD. 2013. Restriction of intestinal stem cell expansion and the regenerative response by YAP. Nature 493(7430):106-10. [PubMed: 23178811] [MGI Ref ID J:194212]
Basseres DS; Ebbs A; Levantini E; Baldwin AS. 2010. Requirement of the NF-kappaB subunit p65/RelA for K-Ras-induced lung tumorigenesis. Cancer Res 70(9):3537-46. [PubMed: 20406971] [MGI Ref ID J:159456]
Battle MA; Bondow BJ; Iverson MA; Adams SJ; Jandacek RJ; Tso P; Duncan SA. 2008. GATA4 is essential for jejunal function in mice. Gastroenterology 135(5):1676-1686.e1. [PubMed: 18812176] [MGI Ref ID J:145635]
Bennecke M; Kriegl L; Bajbouj M; Retzlaff K; Robine S; Jung A; Arkan MC; Kirchner T; Greten FR. 2010. Ink4a/Arf and oncogene-induced senescence prevent tumor progression during alternative colorectal tumorigenesis. Cancer Cell 18(2):135-46. [PubMed: 20708155] [MGI Ref ID J:163673]
Bollrath J; Phesse TJ; von Burstin VA; Putoczki T; Bennecke M; Bateman T; Nebelsiek T; Lundgren-May T; Canli O; Schwitalla S; Matthews V; Schmid RM; Kirchner T; Arkan MC; Ernst M; Greten FR. 2009. gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis. Cancer Cell 15(2):91-102. [PubMed: 19185844] [MGI Ref ID J:144814]
Brunham LR; Kruit JK; Iqbal J; Fievet C; Timmins JM; Pape TD; Coburn BA; Bissada N; Staels B; Groen AK; Hussain MM; Parks JS; Kuipers F; Hayden MR. 2006. Intestinal ABCA1 directly contributes to HDL biogenesis in vivo. J Clin Invest 116(4):1052-62. [PubMed: 16543947] [MGI Ref ID J:107802]
Brunham LR; Kruit JK; Pape TD; Parks JS; Kuipers F; Hayden MR. 2006. Tissue-specific induction of intestinal ABCA1 expression with a liver X receptor agonist raises plasma HDL cholesterol levels. Circ Res 99(7):672-4. [PubMed: 16946132] [MGI Ref ID J:126507]
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Cadwell K; Liu JY; Brown SL; Miyoshi H; Loh J; Lennerz JK; Kishi C; Kc W; Carrero JA; Hunt S; Stone CD; Brunt EM; Xavier RJ; Sleckman BP; Li E; Mizushima N; Stappenbeck TS; Virgin HW 4th. 2008. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 456(7219):259-63. [PubMed: 18849966] [MGI Ref ID J:141419]
Cai J; Zhang N; Zheng Y; de Wilde RF; Maitra A; Pan D. 2010. The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program. Genes Dev 24(21):2383-8. [PubMed: 21041407] [MGI Ref ID J:165471]
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Cellurale C; Girnius N; Jiang F; Cavanagh-Kyros J; Lu S; Garlick DS; Mercurio AM; Davis RJ. 2012. Role of JNK in mammary gland development and breast cancer. Cancer Res 72(2):472-81. [PubMed: 22127926] [MGI Ref ID J:181146]
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Darsigny M; Babeu JP; Dupuis AA; Furth EE; Seidman EG; Levy E; Verdu EF; Gendron FP; Boudreau F. 2009. Loss of hepatocyte-nuclear-factor-4alpha affects colonic ion transport and causes chronic inflammation resembling inflammatory bowel disease in mice. PLoS One 4(10):e7609. [PubMed: 19898610] [MGI Ref ID J:158289]
Darsigny M; Babeu JP; Seidman EG; Gendron FP; Levy E; Carrier J; Perreault N; Boudreau F. 2010. Hepatocyte nuclear factor-4alpha promotes gut neoplasia in mice and protects against the production of reactive oxygen species. Cancer Res 70(22):9423-33. [PubMed: 21062980] [MGI Ref ID J:166855]
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Firestein R; Blander G; Michan S; Oberdoerffer P; Ogino S; Campbell J; Bhimavarapu A; Luikenhuis S; de Cabo R; Fuchs C; Hahn WC; Guarente LP; Sinclair DA. 2008. The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS ONE 3(4):e2020. [PubMed: 18414679] [MGI Ref ID J:134301]
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Genetic Resource Sciences at The Jackson Laboratory. 2012. Expression/Specificity Patterns of Cre Alleles, 2012 MGI Direct Data Submission :. [MGI Ref ID J:184579]
Ghaleb AM; McConnell BB; Kaestner KH; Yang VW. 2011. Altered intestinal epithelial homeostasis in mice with intestine-specific deletion of the Kruppel-like factor 4 gene. Dev Biol 349(2):310-20. [PubMed: 21070761] [MGI Ref ID J:168026]
Good M; Siggers RH; Sodhi CP; Afrazi A; Alkhudari F; Egan CE; Neal MD; Yazji I; Jia H; Lin J; Branca MF; Ma C; Prindle T; Grant Z; Shah S; Slagle D 2nd; Paredes J; Ozolek J; Gittes GK; Hackam DJ. 2012. Amniotic fluid inhibits Toll-like receptor 4 signaling in the fetal and neonatal intestinal epithelium. Proc Natl Acad Sci U S A 109(28):11330-5. [PubMed: 22733781] [MGI Ref ID J:186398]
Grim JE; Knoblaugh SE; Guthrie KA; Hagar A; Swanger J; Hespelt J; Delrow JJ; Small T; Grady WM; Nakayama KI; Clurman BE. 2012. Fbw7 and p53 cooperatively suppress advanced and chromosomally unstable intestinal cancer. Mol Cell Biol 32(11):2160-7. [PubMed: 22473991] [MGI Ref ID J:185723]
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Inoue J; Nishiumi S; Fujishima Y; Masuda A; Shiomi H; Yamamoto K; Nishida M; Azuma T; Yoshida M. 2012. Autophagy in the intestinal epithelium regulates Citrobacter rodentium infection. Arch Biochem Biophys 521(1-2):95-101. [PubMed: 22475450] [MGI Ref ID J:196837]
Iqbal J; Li X; Chang BH; Chan L; Schwartz GJ; Chua SC Jr; Hussain MM. 2010. An intrinsic gut leptin-melanocortin pathway modulates intestinal microsomal triglyceride transfer protein and lipid absorption. J Lipid Res 51(7):1929-42. [PubMed: 20164094] [MGI Ref ID J:162835]
Ishikawa TO; Herschman HR. 2010. Conditional Bicistronic Cre Reporter Line Expressing Both Firefly Luciferase and beta-galactosidase. Mol Imaging Biol :. [PubMed: 20495880] [MGI Ref ID J:165837]
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Jaschke A; Chung B; Hesse D; Kluge R; Zahn C; Moser M; Petzke KJ; Brigelius-Flohe R; Puchkov D; Koepsell H; Heeren J; Joost HG; Schurmann A. 2012. The GTPase ARFRP1 controls the lipidation of chylomicrons in the Golgi of the intestinal epithelium. Hum Mol Genet 21(14):3128-42. [PubMed: 22505585] [MGI Ref ID J:185281]
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Langlois MJ; Roy SA; Auclair BA; Jones C; Boudreau F; Carrier JC; Rivard N; Perreault N. 2009. Epithelial phosphatase and tensin homolog regulates intestinal architecture and secretory cell commitment and acts as a modifier gene in neoplasia. FASEB J 23(6):1835-44. [PubMed: 19168705] [MGI Ref ID J:150553]
Lee D; Yu M; Lee E; Kim H; Yang Y; Kim K; Pannicia C; Kurie JM; Threadgill DW. 2009. Tumor-specific apoptosis caused by deletion of the ERBB3 pseudo-kinase in mouse intestinal epithelium. J Clin Invest 119(9):2702-13. [PubMed: 19690388] [MGI Ref ID J:152703]
Lee J; Kim JC; Lee SE; Quinley C; Kim H; Herdman S; Corr M; Raz E. 2012. Signal transducer and activator of transcription 3 (STAT3) protein suppresses adenoma-to-carcinoma transition in Apcmin/+ mice via regulation of Snail-1 (SNAI) protein stability. J Biol Chem 287(22):18182-9. [PubMed: 22496368] [MGI Ref ID J:185613]
Lee YK; Schmidt DR; Cummins CL; Choi M; Peng L; Zhang Y; Goodwin B; Hammer RE; Mangelsdorf DJ; Kliewer SA. 2008. Liver receptor homolog-1 regulates bile Acid homeostasis but is not essential for feedback regulation of bile Acid synthesis. Mol Endocrinol 22(6):1345-56. [PubMed: 18323469] [MGI Ref ID J:135822]
Leoni G; Alam A; Neumann PA; Lambeth JD; Cheng G; McCoy J; Hilgarth RS; Kundu K; Murthy N; Kusters D; Reutelingsperger C; Perretti M; Parkos CA; Neish AS; Nusrat A. 2013. Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. J Clin Invest 123(1):443-54. [PubMed: 23241962] [MGI Ref ID J:194294]
Lieben L; Masuyama R; Torrekens S; Van Looveren R; Schrooten J; Baatsen P; Lafage-Proust MH; Dresselaers T; Feng JQ; Bonewald LF; Meyer MB; Pike JW; Bouillon R; Carmeliet G. 2012. Normocalcemia is maintained in mice under conditions of calcium malabsorption by vitamin D-induced inhibition of bone mineralization. J Clin Invest 122(5):1803-15. [PubMed: 22523068] [MGI Ref ID J:184529]
List K; Kosa P; Szabo R; Bey AL; Wang CB; Molinolo A; Bugge TH. 2009. Epithelial integrity is maintained by a matriptase-dependent proteolytic pathway. Am J Pathol 175(4):1453-63. [PubMed: 19717635] [MGI Ref ID J:153070]
Liu JY; Seno H; Miletic AV; Mills JC; Swat W; Stappenbeck TS. 2009. Vav proteins are necessary for correct differentiation of mouse cecal and colonic enterocytes. J Cell Sci 122(Pt 3):324-34. [PubMed: 19139088] [MGI Ref ID J:146174]
Lozovatsky L; Abayasekara N; Piawah S; Walther Z. 2009. CASK deletion in intestinal epithelia causes mislocalization of LIN7C and the DLG1/Scrib polarity complex without affecting cell polarity. Mol Biol Cell 20(21):4489-99. [PubMed: 19726564] [MGI Ref ID J:164479]
Luebke-Wheeler J; Zhang K; Battle M; Si-Tayeb K; Garrison W; Chhinder S; Li J; Kaufman RJ; Duncan SA. 2008. Hepatocyte nuclear factor 4alpha is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H. Hepatology 48(4):1242-50. [PubMed: 18704925] [MGI Ref ID J:140018]
McAllister CS; Lakhdari O; Pineton de Chambrun G; Gareau MG; Broquet A; Lee GH; Shenouda S; Eckmann L; Kagnoff MF. 2013. TLR3, TRIF, and Caspase 8 Determine Double-Stranded RNA-Induced Epithelial Cell Death and Survival In Vivo. J Immunol 190(1):418-27. [PubMed: 23209324] [MGI Ref ID J:190822]
McDole JR; Wheeler LW; McDonald KG; Wang B; Konjufca V; Knoop KA; Newberry RD; Miller MJ. 2012. Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine. Nature 483(7389):345-9. [PubMed: 22422267] [MGI Ref ID J:182576]
Mensah-Osman E; Zavros Y; Merchant JL. 2008. Somatostatin stimulates menin gene expression by inhibiting protein kinase A. Am J Physiol Gastrointest Liver Physiol 295(4):G843-54. [PubMed: 18755809] [MGI Ref ID J:142454]
Mori-Akiyama Y; van den Born M; van Es JH; Hamilton SR; Adams HP; Zhang J; Clevers H; de Crombrugghe B. 2007. SOX9 is required for the differentiation of paneth cells in the intestinal epithelium. Gastroenterology 133(2):539-46. [PubMed: 17681175] [MGI Ref ID J:128277]
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Qiao XT; Ziel JW; McKimpson W; Madison BB; Todisco A; Merchant JL; Samuelson LC; Gumucio DL. 2007. Prospective identification of a multilineage progenitor in murine stomach epithelium. Gastroenterology 133(6):1989-98. [PubMed: 18054570] [MGI Ref ID J:135613]
Raetz M; Hwang SH; Wilhelm CL; Kirkland D; Benson A; Sturge CR; Mirpuri J; Vaishnava S; Hou B; Defranco AL; Gilpin CJ; Hooper LV; Yarovinsky F. 2013. Parasite-induced T(H)1 cells and intestinal dysbiosis cooperate in IFN-gamma-dependent elimination of Paneth cells. Nat Immunol 14(2):136-42. [PubMed: 23263554] [MGI Ref ID J:192614]
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Rigby RJ; Simmons JG; Greenhalgh CJ; Alexander WS; Lund PK. 2007. Suppressor of cytokine signaling 3 (SOCS3) limits damage-induced crypt hyper-proliferation and inflammation-associated tumorigenesis in the colon. Oncogene 26(33):4833-41. [PubMed: 17297444] [MGI Ref ID J:125546]
Roulis M; Armaka M; Manoloukos M; Apostolaki M; Kollias G. 2011. Intestinal epithelial cells as producers but not targets of chronic TNF suffice to cause murine Crohn-like pathology. Proc Natl Acad Sci U S A 108(13):5396-401. [PubMed: 21402942] [MGI Ref ID J:171234]
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Sato T; Mushiake S; Kato Y; Sato K; Sato M; Takeda N; Ozono K; Miki K; Kubo Y; Tsuji A; Harada R; Harada A. 2007. The Rab8 GTPase regulates apical protein localization in intestinal cells. Nature 448(7151):366-9. [PubMed: 17597763] [MGI Ref ID J:123415]
Schwitalla S; Ziegler PK; Horst D; Becker V; Kerle I; Begus-Nahrmann Y; Lechel A; Rudolph KL; Langer R; Slotta-Huspenina J; Bader FG; Prazeres da Costa O; Neurath MF; Meining A; Kirchner T; Greten FR. 2013. Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors. Cancer Cell 23(1):93-106. [PubMed: 23273920] [MGI Ref ID J:194357]
Shaked H; Hofseth LJ; Chumanevich A; Chumanevich AA; Wang J; Wang Y; Taniguchi K; Guma M; Shenouda S; Clevers H; Harris CC; Karin M. 2012. Chronic epithelial NF-kappaB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation. Proc Natl Acad Sci U S A 109(35):14007-12. [PubMed: 22893683] [MGI Ref ID J:189809]
Shroyer NF; Helmrath MA; Wang VY; Antalffy B; Henning SJ; Zoghbi HY. 2007. Intestine-specific ablation of mouse atonal homolog 1 (Math1) reveals a role in cellular homeostasis. Gastroenterology 132(7):2478-88. [PubMed: 17570220] [MGI Ref ID J:128312]
Smalley-Freed WG; Efimov A; Burnett PE; Short SP; Davis MA; Gumucio DL; Washington MK; Coffey RJ; Reynolds AB. 2010. p120-catenin is essential for maintenance of barrier function and intestinal homeostasis in mice. J Clin Invest 120(6):1824-35. [PubMed: 20484816] [MGI Ref ID J:161638]
Sodhi CP; Li J; Duncan SA. 2006. Generation of mice harbouring a conditional loss-of-function allele of Gata6. BMC Dev Biol 6:19. [PubMed: 16611361] [MGI Ref ID J:111388]
Sodhi CP; Neal MD; Siggers R; Sho S; Ma C; Branca MF; Prindle T Jr; Russo AM; Afrazi A; Good M; Brower-Sinning R; Firek B; Morowitz MJ; Ozolek JA; Gittes GK; Billiar TR; Hackam DJ. 2012. Intestinal epithelial Toll-like receptor 4 regulates goblet cell development and is required for necrotizing enterocolitis in mice. Gastroenterology 143(3):708-18.e1-5. [PubMed: 22796522] [MGI Ref ID J:193668]
Steinbrecher KA; Harmel-Laws E; Sitcheran R; Baldwin AS. 2008. Loss of epithelial RelA results in deregulated intestinal proliferative/apoptotic homeostasis and susceptibility to inflammation. J Immunol 180(4):2588-99. [PubMed: 18250470] [MGI Ref ID J:131977]
Stroeve JH; Brufau G; Stellaard F; Gonzalez FJ; Staels B; Kuipers F. 2010. Intestinal FXR-mediated FGF15 production contributes to diurnal control of hepatic bile acid synthesis in mice. Lab Invest 90(10):1457-67. [PubMed: 20531290] [MGI Ref ID J:164410]
Tanaka-Okamoto M; Hori K; Ishizaki H; Itoh Y; Onishi S; Yonemura S; Takai Y; Miyoshi J. 2011. Involvement of afadin in barrier function and homeostasis of mouse intestinal epithelia. J Cell Sci 124(Pt 13):2231-40. [PubMed: 21652626] [MGI Ref ID J:183057]
Trobridge P; Knoblaugh S; Washington MK; Munoz NM; Tsuchiya KD; Rojas A; Song X; Ulrich CM; Sasazuki T; Shirasawa S; Grady WM. 2009. TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway. Gastroenterology 136(5):1680-8.e7. [PubMed: 19208363] [MGI Ref ID J:148720]
Tunaru S; Althoff TF; Nusing RM; Diener M; Offermanns S. 2012. Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP3 receptors. Proc Natl Acad Sci U S A 109(23):9179-84. [PubMed: 22615395] [MGI Ref ID J:184842]
Vaishnava S; Yamamoto M; Severson KM; Ruhn KA; Yu X; Koren O; Ley R; Wakeland EK; Hooper LV. 2011. The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine. Science 334(6053):255-8. [PubMed: 21998396] [MGI Ref ID J:177506]
Valentin-Vega YA; Box N; Terzian T; Lozano G. 2009. Mdm4 loss in the intestinal epithelium leads to compartmentalized cell death but no tissue abnormalities. Differentiation 77(5):442-9. [PubMed: 19371999] [MGI Ref ID J:149219]
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Vlantis K; Wullaert A; Sasaki Y; Schmidt-Supprian M; Rajewsky K; Roskams T; Pasparakis M. 2011. Constitutive IKK2 activation in intestinal epithelial cells induces intestinal tumors in mice. J Clin Invest 121(7):2781-93. [PubMed: 21701067] [MGI Ref ID J:175629]
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Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX12
Colony Maintenance
Breeding & Husbandry The strain is maintained as a hemizygote. Mating System Noncarrier x Hemizygote (Female x Male) 01-FEB-13 Hemizygote x Noncarrier (Female x Male) 01-FEB-13 Diet Information LabDiet® 5K52/5K67
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $232.00 Female or Male Hemizygous for Tg(Vil-cre)997Gum
Price per Pair (US dollars $) Pair Genotype $302.00 Hemizygous for Tg(Vil-cre)997Gum x Noncarrier $302.00 Noncarrier x Hemizygous for Tg(Vil-cre)997Gum Standard Supply
Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.
| Pricing for International shipping destinations |
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Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $301.60 Female or Male Hemizygous for Tg(Vil-cre)997Gum
Price per Pair (US dollars $) Pair Genotype $392.60 Hemizygous for Tg(Vil-cre)997Gum x Noncarrier $392.60 Noncarrier x Hemizygous for Tg(Vil-cre)997Gum Standard Supply
Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.
|
|
|
Standard Supply
Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.