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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
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Description
Strain Information
Former Names B6;SJL-Tg(Vil-cre)997Gum (Changed: 15-DEC-04 ) Type Congenic; Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Inbred x Hemizygote (Female x Male) 01-MAR-06 Species laboratory mouse Generation N5+18 (22-SEP-09) Donating Investigator Deborah Gumucio, University of Michigan Description
Mice hemizygous for this transgene express Cre recombinase under the direction of the mouse villin 1 promoter. When crossed with a strain containing a loxP site-flanked sequence of interest, Cre-mediated recombination results in tissue-specific deletion of the target. Recombination occurs in villi and crypt cells of the small and large intestines, closely patterning the endogenous gene expression. The Donating Investigator indicates that expression is generally continuous, but that a small amount of mosaicism is noted in the colon. Onset of transgene expression is at 12.5 dpc, which is delayed from the endogenous mouse Vil1 gene expression onset of 9.0 dpc. Hemizygous mutant mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. This mutant mouse strain may be useful in studies of intestinal organogenesis.Development
A transgenic construct containing the coding domain of Cre recombinase, driven by a 12.4 kb fragment of the mouse villin 1 gene, and a metallothionein polyadenylation site sequence was injected into the pronuclei of fertilized C57BL/6J X SJL/J mouse eggs. Founder animals were bred to C57BL/6 mice and then backcrossed to the same for 5 generations.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of cre
View Strains carrying other alleles of cre (162 strains)
Additional Web Information
Introduction to Cre-lox technology
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
cre relatedResearch Tools
Cre-lox System
Cre Recombinase Expression
Developmental Biology Research
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis: Cre-lox System
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis: Cre-lox System
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Tg(Vil-cre)997Gum | ||
|---|---|---|---|
| Allele Name | transgene insertion 997, Deborah L Gumucio | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | 12.4KbVilCre; Tg(Vil-cre)997Gum; Villin-cre; Villin.cre; VillinCre; | ||
| Mutation Made By | Blair Madison, University of Michigan | ||
| Strain of Origin | (C57BL/6J x SJL)F1 | ||
| Site of Expression | epithelial cells of the small and large intestines; onset of expression is at 12.5 d.p.c.; expression is generally continuous, but a small amount of mosaicism is noted in the colon | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | Vill, villin-like, mouse, laboratory | ||
| Gene Symbol and Name | Tg(Vil-cre)997Gum, transgene insertion 997, Deborah L Gumucio | ||
| Chromosome | UN | ||
| Gene Common Name(s) | 12.4KbVilCre; Tg(Vil-cre)997Gum; Villin-cre; Villin.cre; VillinCre; | ||
| Driver Note | Vil | ||
| General Note | Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. | ||
| Molecular Note | A 12.4-kb promoter fragment from the villin gene drives the expression of Cre recombinase. Recombination occurs in villi and crypt cells of the small and large intestines, closely patterning the endogenous gene expression. According to the corresponding author (J:78815), expression is generally continuous but a small amount of mosaicism is noted in the colon. Onset of transgene expression is at 12.5 dpc, which is delayed from the endogenous mouse Vil gene expression onset of 9.0 dpc. [MGI Ref ID J:78815] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Generic Cre Melt Curve Analysis, Melt Curve Analysis
Tg(Vil-cre)997Gum, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Madison BB; Dunbar L; Qiao XT; Braunstein K; Braunstein E; Gumucio DL. 2002. cis Elements of the Villin Gene Control Expression in Restricted Domains of the Vertical (Crypt) and Horizontal (Duodenum, Cecum) Axes of the Intestine. J Biol Chem 277(36):33275-83. [PubMed: 12065599] [MGI Ref ID J:78815]
Additional References
Tg(Vil-cre)997Gum relatedAuclair BA; Benoit YD; Rivard N; Mishina Y; Perreault N. 2007. Bone morphogenetic protein signaling is essential for terminal differentiation of the intestinal secretory cell lineage. Gastroenterology 133(3):887-96. [PubMed: 17678919] [MGI Ref ID J:128279]
Babeu JP; Darsigny M; Lussier CR; Boudreau F. 2009. Hepatocyte nuclear factor 4alpha contributes to an intestinal epithelial phenotype in vitro and plays a partial role in mouse intestinal epithelium differentiation. Am J Physiol Gastrointest Liver Physiol 297(1):G124-34. [PubMed: 19389805] [MGI Ref ID J:151206]
Battle MA; Bondow BJ; Iverson MA; Adams SJ; Jandacek RJ; Tso P; Duncan SA. 2008. GATA4 is essential for jejunal function in mice. Gastroenterology 135(5):1676-1686.e1. [PubMed: 18812176] [MGI Ref ID J:145635]
Bollrath J; Phesse TJ; von Burstin VA; Putoczki T; Bennecke M; Bateman T; Nebelsiek T; Lundgren-May T; Canli O; Schwitalla S; Matthews V; Schmid RM; Kirchner T; Arkan MC; Ernst M; Greten FR. 2009. gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis. Cancer Cell 15(2):91-102. [PubMed: 19185844] [MGI Ref ID J:144814]
Brunham LR; Kruit JK; Iqbal J; Fievet C; Timmins JM; Pape TD; Coburn BA; Bissada N; Staels B; Groen AK; Hussain MM; Parks JS; Kuipers F; Hayden MR. 2006. Intestinal ABCA1 directly contributes to HDL biogenesis in vivo. J Clin Invest 116(4):1052-62. [PubMed: 16543947] [MGI Ref ID J:107802]
Brunham LR; Kruit JK; Pape TD; Parks JS; Kuipers F; Hayden MR. 2006. Tissue-specific induction of intestinal ABCA1 expression with a liver X receptor agonist raises plasma HDL cholesterol levels. Circ Res 99(7):672-4. [PubMed: 16946132] [MGI Ref ID J:126507]
Cadwell K; Liu JY; Brown SL; Miyoshi H; Loh J; Lennerz JK; Kishi C; Kc W; Carrero JA; Hunt S; Stone CD; Brunt EM; Xavier RJ; Sleckman BP; Li E; Mizushima N; Stappenbeck TS; Virgin HW th. 2008. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 456(7219):259-63. [PubMed: 18849966] [MGI Ref ID J:141419]
Calcagno SR; Li S; Colon M; Kreinest PA; Thompson EA; Fields AP; Murray NR. 2008. Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colon. Int J Cancer 122(11):2462-70. [PubMed: 18271008] [MGI Ref ID J:135568]
Davies PS; Powell AE; Swain JR; Wong MH. 2009. Inflammation and proliferation act together to mediate intestinal cell fusion. PLoS One 4(8):e6530. [PubMed: 19657387] [MGI Ref ID J:152479]
Eckmann L; Nebelsiek T; Fingerle AA; Dann SM; Mages J; Lang R; Robine S; Kagnoff MF; Schmid RM; Karin M; Arkan MC; Greten FR. 2008. Opposing functions of IKKbeta during acute and chronic intestinal inflammation. Proc Natl Acad Sci U S A 105(39):15058-63. [PubMed: 18815378] [MGI Ref ID J:143368]
Firestein R; Blander G; Michan S; Oberdoerffer P; Ogino S; Campbell J; Bhimavarapu A; Luikenhuis S; de Cabo R; Fuchs C; Hahn WC; Guarente LP; Sinclair DA. 2008. The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS ONE 3(4):e2020. [PubMed: 18414679] [MGI Ref ID J:134301]
Galy B; Ferring-Appel D; Kaden S; Grone HJ; Hentze MW. 2008. Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum. Cell Metab 7(1):79-85. [PubMed: 18177727] [MGI Ref ID J:131013]
Grivennikov S; Karin E; Terzic J; Mucida D; Yu GY; Vallabhapurapu S; Scheller J; Rose-John S; Cheroutre H; Eckmann L; Karin M. 2009. IL-6 and stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell 15(2):103-13. [PubMed: 19185845] [MGI Ref ID J:144813]
Guilmeau S; Flandez M; Bancroft L; Sellers RS; Tear B; Stanley P; Augenlicht LH. 2008. Intestinal deletion of Pofut1 in the mouse inactivates notch signaling and causes enterocolitis. Gastroenterology 135(3):849-60, 860.e1-6. [PubMed: 18621050] [MGI Ref ID J:140424]
Hinoi T; Akyol A; Theisen BK; Ferguson DO; Greenson JK; Williams BO; Cho KR; Fearon ER. 2007. Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation. Cancer Res 67(20):9721-30. [PubMed: 17942902] [MGI Ref ID J:126018]
Ianari A; Natale T; Calo E; Ferretti E; Alesse E; Screpanti I; Haigis K; Gulino A; Lees JA. 2009. Proapoptotic function of the retinoblastoma tumor suppressor protein. Cancer Cell 15(3):184-94. [PubMed: 19249677] [MGI Ref ID J:145939]
Jones RG; Li X; Gray PD; Kuang J; Clayton F; Samowitz WS; Madison BB; Gumucio DL; Kuwada SK. 2006. Conditional deletion of beta1 integrins in the intestinal epithelium causes a loss of Hedgehog expression, intestinal hyperplasia, and early postnatal lethality. J Cell Biol 175(3):505-14. [PubMed: 17088430] [MGI Ref ID J:119155]
Kajino-Sakamoto R; Inagaki M; Lippert E; Akira S; Robine S; Matsumoto K; Jobin C; Ninomiya-Tsuji J. 2008. Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis. J Immunol 181(2):1143-52. [PubMed: 18606667] [MGI Ref ID J:137419]
Kim I; Ahn SH; Inagaki T; Choi M; Ito S; Guo GL; Kliewer SA; Gonzalez FJ. 2007. Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine. J Lipid Res 48(12):2664-72. [PubMed: 17720959] [MGI Ref ID J:129978]
Kim JY; Kajino-Sakamoto R; Omori E; Jobin C; Ninomiya-Tsuji J. 2009. Intestinal epithelial-derived TAK1 signaling is essential for cytoprotection against chemical-induced colitis. PLoS ONE 4(2):e4561. [PubMed: 19234607] [MGI Ref ID J:146227]
Langlois MJ; Roy SA; Auclair BA; Jones C; Boudreau F; Carrier JC; Rivard N; Perreault N. 2009. Epithelial phosphatase and tensin homolog regulates intestinal architecture and secretory cell commitment and acts as a modifier gene in neoplasia. FASEB J 23(6):1835-44. [PubMed: 19168705] [MGI Ref ID J:150553]
Lee D; Yu M; Lee E; Kim H; Yang Y; Kim K; Pannicia C; Kurie JM; Threadgill DW. 2009. Tumor-specific apoptosis caused by deletion of the ERBB3 pseudo-kinase in mouse intestinal epithelium. J Clin Invest 119(9):2702-13. [PubMed: 19690388] [MGI Ref ID J:152703]
Lee YK; Schmidt DR; Cummins CL; Choi M; Peng L; Zhang Y; Goodwin B; Hammer RE; Mangelsdorf DJ; Kliewer SA. 2008. Liver receptor homolog-1 regulates bile Acid homeostasis but is not essential for feedback regulation of bile Acid synthesis. Mol Endocrinol 22(6):1345-56. [PubMed: 18323469] [MGI Ref ID J:135822]
List K; Kosa P; Szabo R; Bey AL; Wang CB; Molinolo A; Bugge TH. 2009. Epithelial integrity is maintained by a matriptase-dependent proteolytic pathway. Am J Pathol 175(4):1453-63. [PubMed: 19717635] [MGI Ref ID J:153070]
Liu JY; Seno H; Miletic AV; Mills JC; Swat W; Stappenbeck TS. 2009. Vav proteins are necessary for correct differentiation of mouse cecal and colonic enterocytes. J Cell Sci 122(Pt 3):324-34. [PubMed: 19139088] [MGI Ref ID J:146174]
Luebke-Wheeler J; Zhang K; Battle M; Si-Tayeb K; Garrison W; Chhinder S; Li J; Kaufman RJ; Duncan SA. 2008. Hepatocyte nuclear factor 4alpha is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H. Hepatology 48(4):1242-50. [PubMed: 18704925] [MGI Ref ID J:140018]
Mensah-Osman E; Zavros Y; Merchant JL. 2008. Somatostatin stimulates menin gene expression by inhibiting protein kinase A. Am J Physiol Gastrointest Liver Physiol 295(4):G843-54. [PubMed: 18755809] [MGI Ref ID J:142454]
Mori-Akiyama Y; van den Born M; van Es JH; Hamilton SR; Adams HP; Zhang J; Clevers H; de Crombrugghe B. 2007. SOX9 is required for the differentiation of paneth cells in the intestinal epithelium. Gastroenterology 133(2):539-46. [PubMed: 17681175] [MGI Ref ID J:128277]
Munoz NM; Upton M; Rojas A; Washington MK; Lin L; Chytil A; Sozmen EG; Madison BB; Pozzi A; Moon RT; Moses HL; Grady WM. 2006. Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation. Cancer Res 66(20):9837-44. [PubMed: 17047044] [MGI Ref ID J:114960]
Murray NR; Weems J; Braun U; Leitges M; Fields AP. 2009. Protein kinase C betaII and PKCiota/lambda: collaborating partners in colon cancer promotion and progression. Cancer Res 69(2):656-62. [PubMed: 19147581] [MGI Ref ID J:143707]
Nenci A; Becker C; Wullaert A; Gareus R; van Loo G; Danese S; Huth M; Nikolaev A; Neufert C; Madison B; Gumucio D; Neurath MF; Pasparakis M. 2007. Epithelial NEMO links innate immunity to chronic intestinal inflammation. Nature 446(7135):557-61. [PubMed: 17361131] [MGI Ref ID J:120854]
Nose Y; Kim BE; Thiele DJ. 2006. Ctr1 drives intestinal copper absorption and is essential for growth, iron metabolism, and neonatal cardiac function. Cell Metab 4(3):235-44. [PubMed: 16950140] [MGI Ref ID J:129741]
Petrova TV; Nykanen A; Norrmen C; Ivanov KI; Andersson LC; Haglund C; Puolakkainen P; Wempe F; von Melchner H; Gradwohl G; Vanharanta S; Aaltonen LA; Saharinen J; Gentile M; Clarke A; Taipale J; Oliver G; Alitalo K. 2008. Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype. Cancer Cell 13(5):407-19. [PubMed: 18455124] [MGI Ref ID J:134772]
Pickert G; Neufert C; Leppkes M; Zheng Y; Wittkopf N; Warntjen M; Lehr HA; Hirth S; Weigmann B; Wirtz S; Ouyang W; Neurath MF; Becker C. 2009. STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing. J Exp Med 206(7):1465-72. [PubMed: 19564350] [MGI Ref ID J:150265]
Qiao XT; Ziel JW; McKimpson W; Madison BB; Todisco A; Merchant JL; Samuelson LC; Gumucio DL. 2007. Prospective identification of a multilineage progenitor in murine stomach epithelium. Gastroenterology 133(6):1989-98. [PubMed: 18054570] [MGI Ref ID J:135613]
Rigby RJ; Simmons JG; Greenhalgh CJ; Alexander WS; Lund PK. 2007. Suppressor of cytokine signaling 3 (SOCS3) limits damage-induced crypt hyper-proliferation and inflammation-associated tumorigenesis in the colon. Oncogene 26(33):4833-41. [PubMed: 17297444] [MGI Ref ID J:125546]
Sato T; Mushiake S; Kato Y; Sato K; Sato M; Takeda N; Ozono K; Miki K; Kubo Y; Tsuji A; Harada R; Harada A. 2007. The Rab8 GTPase regulates apical protein localization in intestinal cells. Nature 448(7151):366-9. [PubMed: 17597763] [MGI Ref ID J:123415]
Shroyer NF; Helmrath MA; Wang VY; Antalffy B; Henning SJ; Zoghbi HY. 2007. Intestine-specific ablation of mouse atonal homolog 1 (Math1) reveals a role in cellular homeostasis. Gastroenterology 132(7):2478-88. [PubMed: 17570220] [MGI Ref ID J:128312]
Sodhi CP; Li J; Duncan SA. 2006. Generation of mice harbouring a conditional loss-of-function allele of Gata6. BMC Dev Biol 6:19. [PubMed: 16611361] [MGI Ref ID J:111388]
Steinbrecher KA; Harmel-Laws E; Sitcheran R; Baldwin AS. 2008. Loss of epithelial RelA results in deregulated intestinal proliferative/apoptotic homeostasis and susceptibility to inflammation. J Immunol 180(4):2588-99. [PubMed: 18250470] [MGI Ref ID J:131977]
Trobridge P; Knoblaugh S; Washington MK; Munoz NM; Tsuchiya KD; Rojas A; Song X; Ulrich CM; Sasazuki T; Shirasawa S; Grady WM. 2009. TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway. Gastroenterology 136(5):1680-8.e7. [PubMed: 19208363] [MGI Ref ID J:148720]
Valentin-Vega YA; Box N; Terzian T; Lozano G. 2009. Mdm4 loss in the intestinal epithelium leads to compartmentalized cell death but no tissue abnormalities. Differentiation 77(5):442-9. [PubMed: 19371999] [MGI Ref ID J:149219]
Vujic Spasic M; Kiss J; Herrmann T; Kessler R; Stolte J; Galy B; Rathkolb B; Wolf E; Stremmel W; Hentze MW; Muckenthaler MU. 2007. Physiologic systemic iron metabolism in mice deficient for duodenal Hfe. Blood 109(10):4511-7. [PubMed: 17264297] [MGI Ref ID J:141745]
Yoshida Y; Wang IC; Yoder HM; Davidson NO; Costa RH. 2007. The forkhead box M1 transcription factor contributes to the development and growth of mouse colorectal cancer. Gastroenterology 132(4):1420-31. [PubMed: 17408638] [MGI Ref ID J:128330]
Zahn C; Jaschke A; Weiske J; Hommel A; Hesse D; Augustin R; Lu L; Hong W; Florian S; Scheepers A; Joost HG; Huber O; Schurmann A. 2008. ADP-ribosylation factor-like GTPase ARFRP1 is required for trans-Golgi to plasma membrane trafficking of E-cadherin. J Biol Chem 283(40):27179-88. [PubMed: 18662990] [MGI Ref ID J:142321]
Zaph C; Troy AE; Taylor BC; Berman-Booty LD; Guild KJ; Du Y; Yost EA; Gruber AD; May MJ; Greten FR; Eckmann L; Karin M; Artis D. 2007. Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis. Nature 446(7135):552-6. [PubMed: 17322906] [MGI Ref ID J:120808]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX12
Colony Maintenance
Mating System Inbred x Hemizygote (Female x Male) 01-MAR-06 Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
|
Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $239.00 Female or Male Hemizygous for Tg(Vil-cre)997Gum
Pairs /Price (US dollars $) Pair Genotype $256.75 C57BL/6J (000664) x Hemizygous for Tg(Vil-cre)997Gum
Additional Supply Details
| Pricing for International shipping destinations |
|
Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $310.70 Female or Male Hemizygous for Tg(Vil-cre)997Gum
Pairs /Price (US dollars $) Pair Genotype $333.80 C57BL/6J (000664) x Hemizygous for Tg(Vil-cre)997Gum
Additional Supply Details
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement. |
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| Supply Notes |
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Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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