Strain Name:


Stock Number:


Order this mouse


Repository- Live

Homozygotes for this transgene are not viable. Hemizygotes express Cre recombinase under the control of the human glial fibrillary acidic protein promoter (GFAP). When crossed with a strain containing loxP site flanked sequence of interest, Cre-mediated recombination results in tissue-specific deletion of the target, and recombination occurs primarily in the central nervous system, affecting astrocytes, oligodendroglia, ependyma and some neurons. This mutant mouse strain represents an effective tool for generating central nervous system specific-targeted mutants.


Strain Information

Former Names FVB-Tg(GFAP-cre)25Mes    (Changed: 15-DEC-04 )
Type Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Mating SystemNoncarrier x Hemizygote         (Female x Male)   25-OCT-08
Specieslaboratory mouse
GenerationN?+1pN22 (17-JUN-15)
Generation Definitions
Donating InvestigatorDr. Albee Messing,   University of Wisconsin-Madison

Mice hemizygous for the transgenic insert are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Mice that are homozygous for the transgene are not viable. This transgenic mouse strain expresses Cre recombinase under the control of the human glial fibrillary acidic protein promoter (GFAP). When crossed with a strain containing loxP site flanked sequence of interest, Cre-mediated recombination results in tissue-specific deletion of the target. Recombination occurs primarily in the central nervous system, affecting astrocytes, oligodendroglia, ependyma and some neurons. Expression activity is also present in periportal cells of the liver. Developmental onset of transgene expression occurs in the dorsal and medial regions of the telencephalon by embryonic day 13.5. In adult cerebellum, only astrocytes are immunoreactive for GFAP or Cre recombinase. This mutant mouse strain represents an effective tool for generating central nervous system specific-targeted mutants.

View cre expression characterization.

A transgenic construct containing a 2.2Kb 5' flanking region of the human GFAP gene, cre coding sequence, the SV40 nuclear localization signal, and a portion of the mouse protamine (Prm1) gene which supplies intronic sequence and a polyadenylation site, was injected into fertilized FVB/N mouse eggs.

Control Information

   001800 FVB/NJ
  Considerations for Choosing Controls

Related Strains

Strains carrying   Tg(GFAP-cre)25Mes allele
026857   D2.FVB-Tg(GFAP-cre)25Mes/SjJ
View Strains carrying   Tg(GFAP-cre)25Mes     (1 strain)

View Strains carrying other alleles of GFAP     (21 strains)

Strains carrying other alleles of cre
004337   129(Cg)-Foxg1tm1(cre)Skm/J
008569   129-Alpltm1(cre)Nagy/J
005989   129;FVB-Tg(PTH-cre)4167Slib/J
007179   129S.Cg-Tg(UBC-cre/ERT2)1Ejb/J
007915   129S.FVB-Tg(Amh-cre)8815Reb/J
003328   129S/Sv-Tg(Prm-cre)58Og/J
026200   129S1.Cg-Tg(Vsx2-cre)2690Chow/J
004302   129S1/Sv-Hprttm1(cre)Mnn/J
022137   129S4.Cg-Tg(Wnt1-cre)2Sor/J
003960   129S6-Tg(Prnp-GFP/cre)1Blw/J
008523   129S6.Cg-Tg(NPHS2-cre)295Lbh/BroJ
009587   B6(129S4)-Et(icre)1402Rdav/J
009588   B6(129S4)-Et(icre)1470Rdav/J
009589   B6(129S4)-Et(icre)1555Rdav/J
009586   B6(129S4)-Et(icre)754Rdav/J
012687   B6(129S4)-Tg(SYN1-icre/mRFP1)9934Rdav/J
010774   B6(Cg)-Calb2tm1(cre)Zjh/J
017562   B6(Cg)-Cd8atm1.1(cre)Koni/J
012704   B6(Cg)-Crhtm1(cre)Zjh/J
018448   B6(Cg)-Foxn1tm3(cre)Nrm/J
026801   B6(Cg)-Ins1tm1.1(cre)Thor/J
016223   B6(Cg)-Tg(Phox2b-cre)3Jke/J
016829   B6(SJL)-Pou5f1tm1.1(cre/Esr1*)Yseg/J
016959   B6.129(Cg)-Foxp3tm4(YFP/cre)Ayr/J
023055   B6.129(Cg)-Krt12tm3(cre)Wwk/J
008320   B6.129-Leprtm2(cre)Rck/J
017526   B6.129-Nos1tm1(cre)Mgmj/J
005697   B6.129-Otx1tm4(cre)Asim/J
018938   B6.129-Tac2tm1.1(cre)Qima/J
017769   B6.129-Trpv1tm1(cre)Bbm/J
004146   B6.129-Tg(Pcp2-cre)2Mpin/J
008710   B6.129P2(129S4)-Hprttm10(Ple162-EGFP/cre)Ems/Mmjax
008877   B6.129P2(129S4)-Hprttm12(Ple177-EGFP/cre)Ems/Mmjax
009116   B6.129P2(129S4)-Hprttm16(Ple167-EGFP/cre)Ems/Mmjax
008709   B6.129P2(129S4)-Hprttm9(Ple178-EGFP/cre)Ems/Mmjax
006785   B6.129P2(C)-Cd19tm1(cre)Cgn/J
006084   B6.129P2(Cg)-Foxg1tm1(cre)Skm/J
010611   B6.129P2(Cg)-Ighg1tm1(IRES-cre)Cgn/J
007770   B6.129P2-Aicdatm1(cre)Mnz/J
004781   B6.129P2-Lyz2tm1(cre)Ifo/J
017320   B6.129P2-Pvalbtm1(cre)Arbr/J
017915   B6.129S(Cg)-Pgrtm1.1(cre)Shah/AndJ
013594   B6.129S-Atoh1tm5.1(Cre/PGR)Hzo/J
021794   B6.129S1(Cg)-Ascl3tm1.1(EGFP/cre)Ovi/J
024637   B6.129S1(SJL)-Nkx2-5tm2(cre)Rph/J
006600   B6.129S1-Mnx1tm4(cre)Tmj/J
005628   B6.129S2-Emx1tm1(cre)Krj/J
022510   B6.129S4-Gpr88tm1.1(cre/GFP)Rpa/J
017578   B6.129S4-Mcpt8tm1(cre)Lky/J
003755   B6.129S4-Meox2tm1(cre)Sor/J
007893   B6.129S4-Myf5tm3(cre)Sor/J
006878   B6.129S6-Taglntm2(cre)Yec/J
012839   B6.129X1(Cg)-Tnfrsf4tm2(cre)Nik/J
008712   B6.129X1-Twist2tm1.1(cre)Dor/J
006054   B6.C-Tg(CMV-cre)1Cgn/J
020811   B6.C-Tg(Pgk1-cre)1Lni/CrsJ
023530   B6.Cg-Avptm1.1(cre)Hze/J
013590   B6.Cg-Braftm1Mmcm Ptentm1Hwu Tg(Tyr-cre/ERT2)13Bos/BosJ
006230   B6.Cg-Cebpatm1Dgt Tg(Mx1-cre)1Cgn/J
012358   B6.Cg-Pvalbtm1.1(cre)Aibs/J
005622   B6.Cg-Shhtm1(EGFP/cre)Cjt/J
022762   B6.Cg-Zfp335tm1.2Caw Emx1tm1(cre)Krj/J
017346   B6.Cg-Tg(A930038C07Rik-cre)1Aibs/J
006149   B6.Cg-Tg(ACTA1-cre)79Jme/J
003574   B6.Cg-Tg(Alb-cre)21Mgn/J
006881   B6.Cg-Tg(Aqp2-cre)1Dek/J
011104   B6.Cg-Tg(Atoh1-cre)1Bfri/J
004682   B6.Cg-Tg(CAG-cre/Esr1*)5Amc/J
008520   B6.Cg-Tg(CD2-cre)4Kio/J
009350   B6.Cg-Tg(CDX2-cre)101Erf/J
009352   B6.Cg-Tg(CDX2-cre*)189Erf/J
027310   B6.Cg-Tg(Camk2a-cre)2Szi/J
027400   B6.Cg-Tg(Camk2a-cre)3Szi/J
005359   B6.Cg-Tg(Camk2a-cre)T29-1Stl/J
022071   B6.Cg-Tg(Cd4-cre)1Cwi/BfluJ
012237   B6.Cg-Tg(Cdh16-cre)91Igr/J
006368   B6.Cg-Tg(Cr2-cre)3Cgn/J
008538   B6.Cg-Tg(Cspg4-cre/Esr1*)BAkik/J
006663   B6.Cg-Tg(Eno2-cre)39Jme/J
005069   B6.Cg-Tg(Fabp4-cre)1Rev/J
012712   B6.Cg-Tg(Fev-cre)1Esd/J
012849   B6.Cg-Tg(GFAP-cre/ERT2)505Fmv/J
012886   B6.Cg-Tg(Gfap-cre)73.12Mvs/J
024098   B6.Cg-Tg(Gfap-cre)77.6Mvs/2J
009642   B6.Cg-Tg(Gh1-cre)1Sac/J
024474   B6.Cg-Tg(Il9-cre)#Stck/J
003573   B6.Cg-Tg(Ins2-cre)25Mgn/J
008068   B6.Cg-Tg(Itgax-cre)1-1Reiz/J
008781   B6.Cg-Tg(Kap-cre)29066/2Sig/J
003802   B6.Cg-Tg(Lck-cre)548Jxm/J
006889   B6.Cg-Tg(Lck-cre)I540Jxm/J
012837   B6.Cg-Tg(Lck-icre)3779Nik/J
009643   B6.Cg-Tg(Lhb-cre)1Sac/J
008330   B6.Cg-Tg(Mc4r-cre)25Rck/J
003556   B6.Cg-Tg(Mx1-cre)1Cgn/J
007742   B6.Cg-Tg(Myh11-cre,-EGFP)2Mik/J
008205   B6.Cg-Tg(NPHS2-cre)295Lbh/J
003771   B6.Cg-Tg(Nes-cre)1Kln/J
010536   B6.Cg-Tg(Pcp2-cre)3555Jdhu/J
005975   B6.Cg-Tg(Plp1-cre/ERT)3Pop/J
008827   B6.Cg-Tg(Prdm1-cre)1Masu/J
005584   B6.Cg-Tg(Prrx1-cre)1Cjt/J
003967   B6.Cg-Tg(Rbp3-cre)528Jxm/J
021614   B6.Cg-Tg(S100A8-cre,-EGFP)1Ilw/J
008454   B6.Cg-Tg(Sox2-cre)1Amc/J
006361   B6.Cg-Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/J
003966   B6.Cg-Tg(Syn1-cre)671Jxm/J
017491   B6.Cg-Tg(Tagln-cre)1Her/J
004128   B6.Cg-Tg(Tek-cre)12Flv/J
008863   B6.Cg-Tg(Tek-cre)1Ywa/J
008601   B6.Cg-Tg(Th-cre)1Tmd/J
012328   B6.Cg-Tg(Tyr-cre/ERT2)13Bos/J
008085   B6.Cg-Tg(UBC-cre/ERT2)1Ejb/J
008610   B6.Cg-Tg(Vav1-cre)A2Kio/J
004586   B6.Cg-Tg(Vil-cre)997Gum/J
021504   B6.Cg-Tg(Vil1-cre)1000Gum/J
008735   B6.Cg-Tg(Wap-cre)11738Mam/JKnwJ
009614   B6.Cg-Tg(Wfs1-cre/ERT2)2Aibs/J
009107   B6.Cg-Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J
022501   B6.Cg-Tg(Wnt1-cre)2Sor/J
006234   B6.Cg-Tg(tetO-cre)1Jaw/J
016832   B6.FVB(129)-Tg(Alb1-cre)1Dlr/J
005657   B6.FVB(129)-Tg(Myh6-cre/Esr1*)1Jmk/J
024688   B6.FVB(129S)-Tg(Pax6-GFP/cre)1Rilm/J
006475   B6.FVB(129S4)-Tg(Ckmm-cre)5Khn/J
006451   B6.FVB(129X1)-Tg(Sim1-cre)1Lowl/J
006333   B6.FVB(Cg)-Tg(Neurog3-cre)C1Able/J
014643   B6.FVB-Tg(CMA1-cre)6Thhe/J
006137   B6.FVB-Tg(Cdh5-cre)7Mlia/J
018980   B6.FVB-Tg(Ddx4-cre)1Dcas/KnwJ
003724   B6.FVB-Tg(EIIa-cre)C5379Lmgd/J
011069   B6.FVB-Tg(Gh1-cre)bKnmn/J
011038   B6.FVB-Tg(Myh6-cre)2182Mds/J
014647   B6.FVB-Tg(Pdx1-cre)6Tuv/J
010714   B6.FVB-Tg(Pomc-cre)1Lowl/J
022791   B6.FVB-Tg(Rorc-cre)1Litt/J
017535   B6.FVB-Tg(Slc32a1-cre)2.1Hzo/FrkJ
017490   B6.FVB-Tg(Stra8-icre)1Reb/LguJ
024670   B6.FVB-Tg(Ucp1-cre)1Evdr/J
003394   B6.FVB-Tg(Zp3-cre)3Mrt/J
006660   B6.SJL-Slc6a3tm1.1(cre)Bkmn/J
003552   B6129-Tg(Wap-cre)11738Mam/J
023161   B6129S-Tg(Foxp3-EGFP/cre)1aJbs/J
021025   B6;129-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm1(tetO-cre)Haho/J
010529   B6;129-Myf5tm1(cre)Mrc/J
010528   B6;129-Myf6tm2(cre)Mrc/J
017525   B6;129-Ntstm1(cre)Mgmj/J
005549   B6;129-Pax3tm1(cre)Joe/J
017968   B6;129-Tg(Cdh5-cre)1Spe/J
024860   B6;129-Tg(Drd1-cre)120Mxu/Mmjax
010988   B6;129P-Cyp11a1tm1(GFP/cre)Pzg/J
008529   B6;129P-Tg(Neurog1-cre/ERT2)1Good/J
012601   B6;129P2-Lyve1tm1.1(EGFP/cre)Cys/J
006668   B6;129P2-Omptm4(cre)Mom/MomJ
008069   B6;129P2-Pvalbtm1(cre)Arbr/J
012373   B6;129S-Hoxb1tm1(cre)Og/J
024234   B6;129S-Oxttm1.1(cre)Dolsn/J
023526   B6;129S-Rorbtm1.1(cre)Hze/J
023527   B6;129S-Slc17a7tm1.1(cre)Hze/J
023525   B6;129S-Snap25tm2.1(cre)Hze/J
021877   B6;129S-Tac1tm1.1(cre)Hze/J
021878   B6;129S-Tac2tm1.1(cre)Hze/J
017685   B6;129S-Wisp3tm1(cre)Mawa/J
007001   B6;129S-Tg(UBC-cre/ERT2)1Ejb/J
009388   B6;129S1-Osr2tm2(cre)Jian/J
012463   B6;129S4-Foxd1tm1(GFP/cre)Amc/J
011105   B6;129S4-Olig1tm1(cre)Rth/J
006410   B6;129S6-Chattm2(cre)Lowl/J
009616   B6;C3-Tg(A930038C07Rik-cre)4Aibs/J
012433   B6;C3-Tg(ACTA1-rtTA,tetO-cre)102Monk/J
008844   B6;C3-Tg(Ctgf-cre)2Aibs/J
008839   B6;C3-Tg(Cyp39a1-cre)1Aibs/J
009117   B6;C3-Tg(Cyp39a1-cre)7Aibs/J
008848   B6;C3-Tg(Mybpc1-cre)2Aibs/J
009111   B6;C3-Tg(Scnn1a-cre)1Aibs/J
009112   B6;C3-Tg(Scnn1a-cre)2Aibs/J
009613   B6;C3-Tg(Scnn1a-cre)3Aibs/J
009103   B6;C3-Tg(Wfs1-cre/ERT2)3Aibs/J
025806   B6;CBA-Tg(Gsx2-cre)1Kess/J
026555   B6;CBA-Tg(Lhx6-cre)1Kess/J
025807   B6;CBA-Tg(Sox10-cre)1Wdr/J
024507   B6;CBA-Tg(Tbx21-cre)1Dlc/J
017494   B6;D-Tg(Tshz3-GFP/cre)43Amc/J
024926   B6;D2-Tg(Fshr-cre)1Ldu/J
003466   B6;D2-Tg(Sycp1-cre)4Min/J
014160   B6;DBA-Tg(S100b-EGFP/cre/ERT2)22Amc/J
014159   B6;DBA-Tg(Tmem100-EGFP/cre/ERT2)30Amc/J
015855   B6;DBA-Tg(Upk3a-GFP/cre/ERT2)26Amc/J
010803   B6;FVB-Tg(Adipoq-cre)1Evdr/J
018422   B6;FVB-Tg(Aicda-cre)1Rcas/J
023748   B6;FVB-Tg(Aldh1l1-cre)JD1884Gsat/J
011087   B6;FVB-Tg(Crh-cre)1Kres/J
008533   B6;FVB-Tg(Cspg4-cre)1Akik/J
003734   B6;FVB-Tg(GZMB-cre)1Jcb/J
015850   B6;SJL-Pde6b+ Tg(Rho-icre)1Ck/Boc
004426   B6;SJL-Tg(Cga-cre)3Sac/J
003554   B6;SJL-Tg(Col2a1-cre)1Bhr/J
017738   B6;SJL-Tg(Foxl1-cre)1Khk/J
005249   B6;SJL-Tg(Krt1-15-cre/PGR)22Cot/J
019893   B6;SJL-Tg(Tex101-icre)2Lzj/J
007252   B6Ei.129S4-Tg(Prm-cre)58Og/EiJ
025524   B6J.B6N(Cg)-Cx3cr1tm1.1(cre)Jung/J
018956   B6N.129P2(B6)-Lyz2tm1(cre)Ifo/J
018958   B6N.129P2-Cd19tm1(cre)Cgn/J
021077   B6N.129S1-Mrgprb4tm3(cre)And/J
018957   B6N.129S6(B6)-Chattm2(cre)Lowl/J
017911   B6N.129S6(Cg)-Esr1tm1.1(cre)And/J
019013   B6N.129S6(Cg)-Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
018974   B6N.B6-Tg(Nr4a1-EGFP/cre)820Khog/J
019021   B6N.Cg-Ccktm1.1(cre)Zjh/J
019022   B6N.Cg-Gad2tm2(cre)Zjh/J
018973   B6N.Cg-Ssttm2.1(cre)Zjh/J
018961   B6N.Cg-Tg(Alb-cre)21Mgn/J
019102   B6N.Cg-Tg(CAG-cre/Esr1*)5Amc/CjDswJ
018966   B6N.Cg-Tg(Camk2a-cre)T29-1Stl/J
018965   B6N.Cg-Tg(Fabp4-cre)1Rev/J
017310   B6N.Cg-Tg(Hsd17b1-icre/ERT2)3Casa/J
018960   B6N.Cg-Tg(Ins2-cre)25Mgn/J
018967   B6N.Cg-Tg(Itgax-cre)1-1Reiz/J
018964   B6N.Cg-Tg(KRT14-cre)1Amc/J
019103   B6N.Cg-Tg(Nes-cre)1Kln/CjDswJ
014094   B6N.Cg-Tg(Sox2-cre)1Amc/J
018968   B6N.Cg-Tg(Vav1-cre)A2Kio/J
018963   B6N.Cg-Tg(Vil-cre)997Gum/J
018972   B6N.FVB(B6)-Tg(Myh6-cre)2182Mds/J
019099   B6N.FVB-Tg(ACTB-cre)2Mrt/CjDswJ
019509   B6N.FVB-Tg(BGLAP-cre)1Clem/J
023047   B6N.FVB-Tg(Dmp1-cre)1Jqfe/BwdJ
017927   B6N.FVB-Tg(Mpz-cre)26Mes/J
003465   BALB/c-Tg(CMV-cre)1Cgn/J
012641   BALB/c-Tg(S100a4-cre)1Egn/YunkJ
010612   C.129P2(Cg)-Ighg1tm1(IRES-cre)Cgn/J
017353   C.129S4(B6)-Il13tm1(YFP/cre)Lky/J
017582   C.129S4(B6)-Mcpt8tm1(cre)Lky/J
004126   C.Cg-Cd19tm1(cre)Cgn Ighb/J
005673   C.Cg-Tg(Mx1-cre)1Cgn/J
006244   C.Cg-Tg(tetO-cre)1Jaw/J
009155   C57BL/6-Cldn6tm1(cre)Dkwu/J
017557   C57BL/6-Tg(BEST1-cre)1Jdun/J
027406   C57BL/6-Tg(CD2-cre)1Lov/J
016097   C57BL/6-Tg(Car1-cre)5Flt/J
011086   C57BL/6-Tg(Cck-cre)CKres/J
008766   C57BL/6-Tg(Cd8a-cre)1Itan/J
026828   C57BL/6-Tg(Cpa3-cre)4Glli/J
006474   C57BL/6-Tg(Grik4-cre)G32-4Stl/J
008314   C57BL/6-Tg(HBB-cre)12Kpe/J
008870   C57BL/6-Tg(Hspa2-cre)1Eddy/J
016261   C57BL/6-Tg(Nes-cre/ERT2)KEisc/J
012906   C57BL/6-Tg(Nes-cre/Esr1*)1Kuan/J
027205   C57BL/6-Tg(Nms-icre)20Ywa/J
016617   C57BL/6-Tg(Nr4a1-EGFP/cre)820Khog/J
020287   C57BL/6-Tg(Pbsn-cre/Esr1*)14Abch/J
013148   C57BL/6-Tg(Pdgfra-cre)1Clc/J
008535   C57BL/6-Tg(Pf4-cre)Q3Rsko/J
024034   C57BL/6-Tg(Pmch-cre)1Rck/J
016583   C57BL/6-Tg(Slc6a3-icre/ERT2)2Gloss/J
006888   C57BL/6-Tg(Zp3-cre)1Gwh/J
003651   C57BL/6-Tg(Zp3-cre)93Knw/J
021119   C57BL/6J-Tg(Dlx2-cre,-mCherry)4Grsr/GrsrJ
021423   C57BL/6J-Tg(Dlx2-cre,-mCherry)9Grsr/GrsrJ
007567   C57BL/6J-Tg(Itgax-cre,-EGFP)4097Ach/J
018895   C57BL/6J-Tg(Krt6,-cre,-Cerulean)1Grsr/Grsr
018896   C57BL/6J-Tg(Krt6,-cre,-Cerulean)2Grsr/Grsr
018898   C57BL/6J-Tg(Krt6,-cre,-Cerulean)4Grsr/Grsr
018899   C57BL/6J-Tg(Krt6,-cre,-Cerulean)5Grsr/Grsr
021582   C57BL/6J-Tg(Mchr1-cre)1Emf/J
008661   C57BL/6J-Tg(Nkx2-1-cre)2Sand/J
022883   C57BL/6J-Tg(Six6-cre)3Grsr/GrsrJ
022887   C57BL/6J-Tg(Six6-cre)7Grsr/GrsrJ
018754   C57BL/6J-Tg(Tbx22,-cre,-mCherry)1Grsr/GrsrJ
019363   C57BL/6J-Tg(Trp63,-cre,-Cerulean)10Grsr/Grsr
018792   C57BL/6J-Tg(Trp63,-cre,-Cerulean)4Grsr/GrsrJ
003650   C57BL/6J-Tg(Zp3-cre)82Knw/KnwJ
018151   C57BL/6N-Krt17tm1(cre,Cerulean)Murr/GrsrJ
023014   C57BL/6N-Tg(Calcrl,cre)4688Nkza/J
012686   C57BL/6N-Tg(Ppp1r2-cre)4127Nkza/J
016582   C57BL/6N-Tg(Slc32a1-icre/ERT2)3Gloss/J
026861   D2.129P2(B6)-Lyz2tm1(cre)Ifo/SjJ
026858   D2.129S4(B6)-Meox2tm1(cre)Sor/SjJ
026266   D2.B6-Tg(Zp3-cre)93Knw/SjJ
026852   D2.Cg-Tg(Gfap-cre)73.12Mvs/SjJ
024701   D2.Cg-Tg(Plp1-cre/ERT)3Pop/SjJ
026859   D2.Cg-Tg(Sox2-cre)1Amc/SjJ
026860   D2.FVB-Tg(Tek-cre)2352Rwng/SjJ
016833   FVB(Cg)-Tg(Alb1-cre)1Dlr/J
012929   FVB(Cg)-Tg(Dhh-cre)1Mejr/J
011034   FVB(Cg)-Tg(Ghrhr-cre)3242Lsk/J
006405   FVB-Tg(Ckmm-cre)5Khn/J
021024   FVB-Tg(Csf1r-icre)1Jwp/J
006954   FVB-Tg(Ddx4-cre)1Dcas/J
011037   FVB-Tg(Myh6-cre)2182Mds/J
006364   FVB-Tg(Nr5a1-cre)2Lowl/J
008537   FVB-Tg(Tek-cre)2352Rwng/J
019382   FVB.Cg-Myh9tm1.1Gac Tg(NPHS2-cre)295Lbh/Mmjax
014140   FVB.Cg-Myod1tm2.1(icre)Glh/J
006139   FVB.Cg-Tg(ACTA1-cre)79Jme/J
017595   FVB.Cg-Tg(CAG-cre/Esr1*)5Amc/J
006297   FVB.Cg-Tg(Eno2-cre)39Jme/J
018394   FVB.Cg-Tg(KRT5-cre/ERT2)2Ipc/JeldJ
008244   FVB.Cg-Tg(tetO-cre)1Jaw/J
003376   FVB/N-Tg(ACTB-cre)2Mrt/J
024384   FVB/N-Tg(AMELX-cre)A1Kul/J
003314   FVB/N-Tg(EIIa-cre)C5379Lmgd/J
025062   FVB/N-Tg(Figla-EGFP,-icre)ZP3Dean/Mmjax
017928   FVB/N-Tg(Mpz-cre)26Mes/J
025066   FVB/N-Tg(Mylpf-cre)3Kraj/Mmjax
006143   FVB/N-Tg(Thy1-cre)1Vln/J
003377   FVB/N-Tg(Zp3-cre)3Mrt/J
023325   FVB;B6-Tg(Pbsn-cre)20Fwan/J
019096   NOD.129P2(B6)-Lyz2tm1(cre)Ifo/NadlJ
023806   NOD.129P2(Cg)-Cd19tm1(cre)Cgn/J
013233   NOD.B6-Tg(Itgax-cre,-EGFP)4097Ach/J
013234   NOD.Cg-Tg(Cd4-cre)1Cwi/2AchJ
023972   NOD.Cg-Tg(Ins2-cre/ERT)1Dam/SbwJ
023203   NOD.Cg-Tg(Itgax-cre)1-1Reiz/PesaJ
005732   NOD.Cg-Tg(Lck-cre)548Jxm/AchJ
023973   NOD.Cg-Tg(Neurog3-cre)1Dam/SbwJ
013251   NOD.FVB-Tg(EIIa-cre)C5379Lmgd/J
008694   NOD/ShiLt-Tg(Foxp3-EGFP/cre)1cJbs/J
004986   NOD/ShiLt-Tg(Ins2-cre)3Lt/LtJ
003855   NOD/ShiLt-Tg(Ins2-cre)5Lt/LtJ
004987   NOD/ShiLt-Tg(Ins2-cre)6Lt/LtJ
012899   STOCK Agrptm1(cre)Lowl/J
026229   STOCK Akap12tm1Ihg Rb1tm2Brn Tg(Pbsn-cre)4Prb/J
012706   STOCK Ccktm1.1(cre)Zjh/J
010910   STOCK Corttm1(cre)Zjh/J
007916   STOCK En1tm2(cre)Wrst/J
008464   STOCK Foxa2tm2.1(cre/Esr1*)Moon/J
010802   STOCK Gad2tm2(cre)Zjh/J
018903   STOCK Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
023407   STOCK HhatTg(TFAP2A-cre)1Will/J
008876   STOCK Hprttm11(Ple176-EGFP/cre)Ems/Mmjax
016879   STOCK Il17atm1.1(icre)Stck/J
024242   STOCK Isl1tm1(cre)Sev/J
018976   STOCK Kdrtm1(cre)Sato/J
017701   STOCK Kiss1tm1.1(cre/EGFP)Stei/J
007022   STOCK Mnx1tm4(cre)Tmj Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
004192   STOCK Mttptm2Sgy Ldlrtm1Her Apobtm2Sgy Tg(Mx1-cre)1Cgn/J
023342   STOCK Myf5tm1(cre/Esr1*)Trdo/J
024713   STOCK Myl1tm1(cre)Sjb/J
014180   STOCK Myocdtm1(cre)Jomm/J
006953   STOCK Notch1tm3(cre)Rko/J
006677   STOCK Olfr151tm28(cre)Mom/MomJ
011103   STOCK Olig2tm2(TVA,cre)Rth/J
010530   STOCK Pax7tm1(cre)Mrc/J
019378   STOCK Ptf1atm2(cre/ESR1)Cvw/J
016963   STOCK Slc17a6tm2(cre)Lowl/J
016962   STOCK Slc32a1tm2(cre)Lowl/J
013044   STOCK Ssttm2.1(cre)Zjh/J
012719   STOCK Tgfb3tm1(cre)Vk/J
012620   STOCK Trp53tm1Brd Brca1tm1Aash Tg(LGB-cre)74Acl/J
008813   STOCK Trpa1tm2Kykw Tg(CAG-cre/Esr1*)5Amc/J
010908   STOCK Viptm1(cre)Zjh/J
010911   STOCK Wt1tm1(EGFP/cre)Wtp/J
008783   STOCK Tg(CAG-cre/Esr1*)5Amc Smn1tm3(SMN2/Smn1)Mrph Tg(SMN2*delta7)4299Ahmb Tg(SMN2)89Ahmb/J
004453   STOCK Tg(CAG-cre/Esr1*)5Amc/J
009615   STOCK Tg(Cartpt-cre)1Aibs/J
017336   STOCK Tg(Cd4-cre)1Cwi/BfluJ
005105   STOCK Tg(Chx10-EGFP/cre,-ALPP)2Clc/J
008861   STOCK Tg(Ela1-Cre/ERT2)1Stof/J
008852   STOCK Tg(En2-cre)22Alj/J
005938   STOCK Tg(Eno2-cre)39Jme/J
022763   STOCK Tg(Eno2-cre/ERT2)1Pohlk/J
011062   STOCK Tg(Gdf9-cre)5092Coo/J
012841   STOCK Tg(Ggt1-cre)M3Egn/J
021207   STOCK Tg(Gnrh1-cre)1Dlc/J
017981   STOCK Tg(Hoxb6-cre)#Mku/J
004692   STOCK Tg(Hoxb7-cre)13Amc/J
014600   STOCK Tg(I12b-cre/ERT2,-ALPP)37Fsh/J
008122   STOCK Tg(Ins2-cre/ERT)1Dam/J
004782   STOCK Tg(KRT14-cre)1Amc/J
005107   STOCK Tg(KRT14-cre/ERT)20Efu/J
008582   STOCK Tg(Kcnc2-Cre)K128Stl/LetJ
023426   STOCK Tg(Kiss1-cre)J2-4Cfe/J
017836   STOCK Tg(LGB-cre)74Acl/J
003551   STOCK Tg(MMTV-cre)1Mam/J
003553   STOCK Tg(MMTV-cre)4Mam/J
002527   STOCK Tg(Mx1-cre)1Cgn/J
009074   STOCK Tg(Myh6-cre)1Jmk/J
005650   STOCK Tg(Myh6-cre/Esr1*)1Jmk/J
009102   STOCK Tg(Nefh-cre)12Kul/J
002858   STOCK Tg(Nes-cre)1Wme/J
002859   STOCK Tg(Nes-cre)2Wme/J
012859   STOCK Tg(Neurog1-cre)1Jejo/J
005667   STOCK Tg(Neurog3-cre)C1Able/J
008119   STOCK Tg(Neurog3-cre/Esr1*)1Dam/J
012462   STOCK Tg(Nr5a1-cre)7Lowl/J
014158   STOCK Tg(Pax4-cre)1Dam/J
024578   STOCK Tg(Pax6-GFP/cre)1Rilm/J
006207   STOCK Tg(Pcp2-cre)1Amc/J
014099   STOCK Tg(Pmch-cre)1Lowl/J
005965   STOCK Tg(Pomc1-cre)16Lowl/J
012452   STOCK Tg(Rr5-GFP/cre)1Sapc/J
006395   STOCK Tg(Sim1-cre)1Lowl/J
009606   STOCK Tg(Six2-EGFP/cre)1Amc/J
019755   STOCK Tg(Six3-cre)69Frty/GcoJ
018147   STOCK Tg(Slc17a8-icre)1Edw/SealJ
012586   STOCK Tg(Slc1a3-cre/ERT)1Nat/J
004783   STOCK Tg(Sox2-cre)1Amc/J
008208   STOCK Tg(Stra8-icre)1Reb/J
016236   STOCK Tg(TCF/Lef1-cre/ERT2)1Dje/J
004746   STOCK Tg(Tagln-cre)1Her/J
012708   STOCK Tg(Thy1-cre/ERT2,-EYFP)HGfng/PyngJ
024240   STOCK Tg(Tnnt2-cre)5Blh/JiaoJ
016584   STOCK Tg(Tph2-icre/ERT2)6Gloss/J
003829   STOCK Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J
008851   STOCK Tg(Wnt1-cre/ERT)1Alj/J
018281   STOCK Tg(Wnt7a-EGFP/cre)#Bhr/Mmjax
008199   STOCK Tg(dlx6a-cre)1Mekk/J
002471   STOCK Tg(hCMV-cre)140Sau/J
023724   STOCK Tg(mI56i-cre,EGFP)1Kc/J
006224   STOCK Tg(tetO-cre)1Jaw/J
View Strains carrying other alleles of cre     (412 strains)

Additional Web Information

Introduction to Cre-lox technology


Phenotype Information

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Neurobiology Research
Cre-lox System
      Cre Recombinase expression in neural tissue

Research Tools
Cre-lox System
      Cre Recombinase Expression
Genetics Research
      Mutagenesis and Transgenesis
      Mutagenesis and Transgenesis: Cre-lox System
Neurobiology Research

cre related

Research Tools
Cre-lox System
Genetics Research
      Mutagenesis and Transgenesis
      Mutagenesis and Transgenesis: Cre-lox System

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol Tg(GFAP-cre)25Mes
Allele Name transgene insertion 25, Albee Messing
Allele Type Transgenic (cre- or Flp-expressing)
Common Name(s) GFAP-Cre; GFAP-Cre-m; Gfa2-Cre; Tg95.2; TgN(GFAPcre)25Mes; TgN25Mes; hGFAP-cre; hGFAP::Cre; hGFAPcre;
Mutation Made ByDr. Albee Messing,   University of Wisconsin-Madison
Strain of OriginFVB/N
Site of Expressionprimarily in the central nervous system, affecting astrocytes, oligodendroglia, ependyma and some neurons; also periportal cells of the liver
Expressed Gene cre, cre recombinase, bacteriophage P1
Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence.
Promoter GFAP, glial fibrillary acidic protein, human
Driver Note GFAP
General Note Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. Mice that are homozygous for the transgene are not viable.
Molecular Note This transgene expresses Cre recombinase under the control of a human glial fibrillary acidic protein (GFAP) promoter. Cre-mediated recombination occurs primarily in the central nervous system, affecting astrocytes, oligodendroglia, ependyma and some neurons. Expression activity is also present in periportal cells of the liver. Developmental onset of transgene expression occurs in the dorsal and medial regions of the telencephalon by embryonic day 13.5. In adult cerebellum, only astrocytes are immunoreactive for GFAP or Cre recombinase. [MGI Ref ID J:72509]


Genotyping Information

Genotyping Protocols

Generic Cre Melt Curve Analysis, MELT
Generic Cre Melt Curve Analysis, Probe
Tg(GFAP-cre)25Mes, Melt Curve Analysis
Tg(GFAP-cre)25Mes, Standard PCR

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Selected Reference(s)

Zhuo L; Theis M; Alvarez-Maya I; Brenner M; Willecke K; Messing A. 2001. hGFAP-cre transgenic mice for manipulation of glial and neuronal function in vivo. Genesis 31(2):85-94. [PubMed: 11668683]  [MGI Ref ID J:72509]

Additional References

Moore SA; Saito F; Chen J; Michele DE; Henry MD; Messing A; Cohn RD; Ross-Barta SE; Westra S; Williamson RA; Hoshi T; Campbell KP. 2002. Deletion of brain dystroglycan recapitulates aspects of congenital muscular dystrophy. Nature 418(6896):422-5. [PubMed: 12140559]  [MGI Ref ID J:86901]

Tg(GFAP-cre)25Mes related

Abel TW; Clark C; Bierie B; Chytil A; Aakre M; Gorska A; Moses HL. 2009. GFAP-Cre-mediated activation of oncogenic K-ras results in expansion of the subventricular zone and infiltrating glioma. Mol Cancer Res 7(5):645-53. [PubMed: 19435821]  [MGI Ref ID J:205246]

Ahlfeld J; Favaro R; Pagella P; Kretzschmar HA; Nicolis S; Schuller U. 2013. Sox2 requirement in sonic hedgehog-associated medulloblastoma. Cancer Res 73(12):3796-807. [PubMed: 23596255]  [MGI Ref ID J:198458]

Akhtar MW; Kim MS; Adachi M; Morris MJ; Qi X; Richardson JA; Bassel-Duby R; Olson EN; Kavalali ET; Monteggia LM. 2012. In vivo analysis of MEF2 transcription factors in synapse regulation and neuronal survival. PLoS One 7(4):e34863. [PubMed: 22496871]  [MGI Ref ID J:207812]

Ango F; Wu C; Van der Want JJ; Wu P; Schachner M; Huang ZJ. 2008. Bergmann glia and the recognition molecule CHL1 organize GABAergic axons and direct innervation of Purkinje cell dendrites. PLoS Biol 6(4):e103. [PubMed: 18447583]  [MGI Ref ID J:136656]

Anthony TE; Heintz N. 2008. Genetic lineage tracing defines distinct neurogenic and gliogenic stages of ventral telencephalic radial glial development. Neural Dev 3:30. [PubMed: 18986511]  [MGI Ref ID J:160736]

Anton ES; Ghashghaei HT; Weber JL; McCann C; Fischer TM; Cheung ID; Gassmann M; Messing A; Klein R; Schwab MH; Lloyd KC; Lai C. 2004. Receptor tyrosine kinase ErbB4 modulates neuroblast migration and placement in the adult forebrain. Nat Neurosci 7(12):1319-28. [PubMed: 15543145]  [MGI Ref ID J:95821]

Barbosa AC; Kim MS; Ertunc M; Adachi M; Nelson ED; McAnally J; Richardson JA; Kavalali ET; Monteggia LM; Bassel-Duby R; Olson EN. 2008. MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function. Proc Natl Acad Sci U S A 105(27):9391-6. [PubMed: 18599438]  [MGI Ref ID J:138188]

Barros CS; Calabrese B; Chamero P; Roberts AJ; Korzus E; Lloyd K; Stowers L; Mayford M; Halpain S; Muller U. 2009. Impaired maturation of dendritic spines without disorganization of cortical cell layers in mice lacking NRG1/ErbB signaling in the central nervous system. Proc Natl Acad Sci U S A 106(11):4507-12. [PubMed: 19240213]  [MGI Ref ID J:146779]

Bashir T; Cloninger C; Artinian N; Anderson L; Bernath A; Holmes B; Benavides-Serrato A; Sabha N; Nishimura RN; Guha A; Gera J. 2012. Conditional astroglial Rictor overexpression induces malignant glioma in mice. PLoS One 7(10):e47741. [PubMed: 23077666]  [MGI Ref ID J:192206]

Benadiba C; Magnani D; Niquille M; Morle L; Valloton D; Nawabi H; Ait-Lounis A; Otsmane B; Reith W; Theil T; Hornung JP; Lebrand C; Durand B. 2012. The ciliogenic transcription factor RFX3 regulates early midline distribution of guidepost neurons required for corpus callosum development. PLoS Genet 8(3):e1002606. [PubMed: 22479201]  [MGI Ref ID J:183848]

Boulay AC; Mazeraud A; Cisternino S; Saubamea B; Mailly P; Jourdren L; Blugeon C; Mignon V; Smirnova M; Cavallo A; Ezan P; Ave P; Dingli F; Loew D; Vieira P; Chretien F; Cohen-Salmon M. 2015. Immune quiescence of the brain is set by astroglial connexin 43. J Neurosci 35(10):4427-39. [PubMed: 25762685]  [MGI Ref ID J:219990]

Cai J; Chen Y; Cai WH; Hurlock EC; Wu H; Kernie SG; Parada LF; Lu QR. 2007. A crucial role for Olig2 in white matter astrocyte development. Development 134(10):1887-99. [PubMed: 17428828]  [MGI Ref ID J:121422]

Cappello S; Attardo A; Wu X; Iwasato T; Itohara S; Wilsch-Brauninger M; Eilken HM; Rieger MA; Schroeder TT; Huttner WB; Brakebusch C; Gotz M. 2006. The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface. Nat Neurosci 9(9):1099-107. [PubMed: 16892058]  [MGI Ref ID J:113146]

Catchpole T; Henkemeyer M. 2011. EphB2 tyrosine kinase-dependent forward signaling in migration of neuronal progenitors that populate and form a distinct region of the dentate niche. J Neurosci 31(32):11472-83. [PubMed: 21832177]  [MGI Ref ID J:175976]

Chen J; Li Y; Yu TS; McKay RM; Burns DK; Kernie SG; Parada LF. 2012. A restricted cell population propagates glioblastoma growth after chemotherapy. Nature 488(7412):522-6. [PubMed: 22854781]  [MGI Ref ID J:186769]

Chen MJ; Kress B; Han X; Moll K; Peng W; Ji RR; Nedergaard M. 2012. Astrocytic CX43 hemichannels and gap junctions play a crucial role in development of chronic neuropathic pain following spinal cord injury. Glia 60(11):1660-70. [PubMed: 22951907]  [MGI Ref ID J:187682]

Chen Y; Miles DK; Hoang T; Shi J; Hurlock E; Kernie SG; Lu QR. 2008. The basic helix-loop-helix transcription factor olig2 is critical for reactive astrocyte proliferation after cortical injury. J Neurosci 28(43):10983-9. [PubMed: 18945906]  [MGI Ref ID J:143796]

Chenaux G; Henkemeyer M. 2011. Forward signaling by EphB1/EphB2 interacting with ephrin-B ligands at the optic chiasm is required to form the ipsilateral projection. Eur J Neurosci 34(10):1620-33. [PubMed: 22103419]  [MGI Ref ID J:184158]

Chever O; Lee CY; Rouach N. 2014. Astroglial connexin43 hemichannels tune basal excitatory synaptic transmission. J Neurosci 34(34):11228-32. [PubMed: 25143604]  [MGI Ref ID J:216167]

Chizhikov VV; Davenport J; Zhang Q; Shih EK; Cabello OA; Fuchs JL; Yoder BK; Millen KJ. 2007. Cilia proteins control cerebellar morphogenesis by promoting expansion of the granule progenitor pool. J Neurosci 27(36):9780-9. [PubMed: 17804638]  [MGI Ref ID J:145113]

Choe Y; Kozlova A; Graf D; Pleasure SJ. 2013. Bone morphogenic protein signaling is a major determinant of dentate development. J Neurosci 33(16):6766-75. [PubMed: 23595735]  [MGI Ref ID J:196652]

Choi JW; Gardell SE; Herr DR; Rivera R; Lee CW; Noguchi K; Teo ST; Yung YC; Lu M; Kennedy G; Chun J. 2011. FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation. Proc Natl Acad Sci U S A 108(2):751-6. [PubMed: 21177428]  [MGI Ref ID J:168824]

Choi YH; Park CH; Kim W; Ling H; Kang A; Chang MW; Im SK; Jeong HW; Kong YY; Kim KT. 2010. Vaccinia-related kinase 1 is required for the maintenance of undifferentiated spermatogonia in mouse male germ cells. PLoS One 5(12):e15254. [PubMed: 21179456]  [MGI Ref ID J:168994]

Chow KH; Shin DM; Jenkins MH; Miller EE; Shih DJ; Choi S; Low BE; Philip V; Rybinski B; Bronson RT; Taylor MD; Yun K. 2014. Epigenetic states of cells of origin and tumor evolution drive tumor-initiating cell phenotype and tumor heterogeneity. Cancer Res 74(17):4864-74. [PubMed: 25136069]  [MGI Ref ID J:214824]

Colombo E; Cordiglieri C; Melli G; Newcombe J; Krumbholz M; Parada LF; Medico E; Hohlfeld R; Meinl E; Farina C. 2012. Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration. J Exp Med 209(3):521-35. [PubMed: 22393127]  [MGI Ref ID J:182678]

Crowther AJ; Gama V; Bevilacqua A; Chang SX; Yuan H; Deshmukh M; Gershon TR. 2013. Tonic activation of Bax primes neural progenitors for rapid apoptosis through a mechanism preserved in medulloblastoma. J Neurosci 33(46):18098-108. [PubMed: 24227720]  [MGI Ref ID J:204171]

D'Arca D; Zhao X; Xu W; Ramirez-Martinez NC; Iavarone A; Lasorella A. 2010. Huwe1 ubiquitin ligase is essential to synchronize neuronal and glial differentiation in the developing cerebellum. Proc Natl Acad Sci U S A 107(13):5875-80. [PubMed: 20231446]  [MGI Ref ID J:158649]

Degen J; Dublin P; Zhang J; Dobrowolski R; Jokwitz M; Karram K; Trotter J; Jabs R; Willecke K; Steinhauser C; Theis M. 2012. Dual reporter approaches for identification of Cre efficacy and astrocyte heterogeneity. FASEB J 26(11):4576-83. [PubMed: 22859373]  [MGI Ref ID J:193352]

Duan LJ; Takeda K; Fong GH. 2014. Hypoxia inducible factor-2alpha regulates the development of retinal astrocytic network by maintaining adequate supply of astrocyte progenitors. PLoS One 9(1):e84736. [PubMed: 24475033]  [MGI Ref ID J:212719]

Eckardt D; Theis M; Doring B; Speidel D; Willecke K; Ott T. 2004. Spontaneous ectopic recombination in cell-type-specific Cre mice removes loxP-flanked marker cassettes in vivo. Genesis 38(4):159-65. [PubMed: 15083516]  [MGI Ref ID J:90577]

Ehmsen JT; Ma TM; Sason H; Rosenberg D; Ogo T; Furuya S; Snyder SH; Wolosker H. 2013. D-Serine in Glia and Neurons Derives from 3-Phosphoglycerate Dehydrogenase. J Neurosci 33(30):12464-12469. [PubMed: 23884950]  [MGI Ref ID J:199792]

Eijkelkamp N; Heijnen CJ; Willemen HL; Deumens R; Joosten EA; Kleibeuker W; den Hartog IJ; van Velthoven CT; Nijboer C; Nassar MA; Dorn GW 2nd; Wood JN; Kavelaars A. 2010. GRK2: a novel cell-specific regulator of severity and duration of inflammatory pain. J Neurosci 30(6):2138-49. [PubMed: 20147541]  [MGI Ref ID J:157847]

Fagel DM; Ganat Y; Cheng E; Silbereis J; Ohkubo Y; Ment LR; Vaccarino FM. 2009. Fgfr1 is required for cortical regeneration and repair after perinatal hypoxia. J Neurosci 29(4):1202-11. [PubMed: 19176828]  [MGI Ref ID J:144824]

Fernandes M; Antoine M; Hebert JM. 2012. SMAD4 is essential for generating subtypes of neurons during cerebellar development. Dev Biol 365(1):82-90. [PubMed: 22370000]  [MGI Ref ID J:184924]

Figiel M; Allritz C; Lehmann C; Engele J. 2007. Gap junctional control of glial glutamate transporter expression. Mol Cell Neurosci 35(1):130-7. [PubMed: 17369047]  [MGI Ref ID J:123230]

Fonseca TL; Correa-Medina M; Campos MP; Wittmann G; Werneck-de-Castro JP; Arrojo e Drigo R; Mora-Garzon M; Ueta CB; Caicedo A; Fekete C; Gereben B; Lechan RM; Bianco AC. 2013. Coordination of hypothalamic and pituitary T3 production regulates TSH expression. J Clin Invest 123(4):1492-500. [PubMed: 23524969]  [MGI Ref ID J:197623]

Frick A; Grammel D; Schmidt F; Poschl J; Priller M; Pagella P; von Bueren AO; Peraud A; Tonn JC; Herms J; Rutkowski S; Kretzschmar HA; Schuller U. 2012. Proper cerebellar development requires expression of beta1-integrin in Bergmann glia, but not in granule neurons. Glia 60(5):820-32. [PubMed: 22374686]  [MGI Ref ID J:181620]

Frisch C; Theis M; De Souza Silva MA; Dere E; Sohl G; Teubner B; Namestkova K; Willecke K; Huston JP. 2003. Mice with astrocyte-directed inactivation of connexin43 exhibit increased exploratory behaviour, impaired motor capacities, and changes in brain acetylcholine levels. Eur J Neurosci 18(8):2313-8. [PubMed: 14622192]  [MGI Ref ID J:89675]

Furrer SA; Mohanachandran MS; Waldherr SM; Chang C; Damian VA; Sopher BL; Garden GA; La Spada AR. 2011. Spinocerebellar ataxia type 7 cerebellar disease requires the coordinated action of mutant ataxin-7 in neurons and glia, and displays non-cell-autonomous bergmann glia degeneration. J Neurosci 31(45):16269-78. [PubMed: 22072678]  [MGI Ref ID J:177834]

Fyffe-Maricich SL; Karlo JC; Landreth GE; Miller RH. 2011. The ERK2 mitogen-activated protein kinase regulates the timing of oligodendrocyte differentiation. J Neurosci 31(3):843-50. [PubMed: 21248107]  [MGI Ref ID J:168564]

Gan Q; Lee A; Suzuki R; Yamagami T; Stokes A; Nguyen BC; Pleasure D; Wang J; Chen HW; Zhou CJ. 2014. Pax6 mediates ss-catenin signaling for self-renewal and neurogenesis by neocortical radial glial stem cells. Stem Cells 32(1):45-58. [PubMed: 24115331]  [MGI Ref ID J:206763]

Garrett AM; Weiner JA. 2009. Control of CNS synapse development by {gamma}-protocadherin-mediated astrocyte-neuron contact. J Neurosci 29(38):11723-31. [PubMed: 19776259]  [MGI Ref ID J:153046]

Genetic Resource Science at The Jackson Laboratory. 2012. Expression/Specificity Patterns of Cre Alleles, 2011 Direct Data Submission from Genetic Resource Science :.  [MGI Ref ID J:184578]

Genovese G; Ergun A; Shukla SA; Campos B; Hanna J; Ghosh P; Quayle SN; Rai K; Colla S; Ying H; Wu CJ; Sarkar S; Xiao Y; Zhang J; Zhang H; Kwong L; Dunn K; Wiedemeyer WR; Brennan C; Zheng H; Rimm DL; Collins JJ; Chin L. 2012. microRNA regulatory network inference identifies miR-34a as a novel regulator of TGF-beta signaling in glioblastoma. Cancer Discov 2(8):736-49. [PubMed: 22750848]  [MGI Ref ID J:193159]

Gershon TR; Crowther AJ; Tikunov A; Garcia I; Annis R; Yuan H; Miller CR; Macdonald J; Olson J; Deshmukh M. 2013. Hexokinase-2-mediated aerobic glycolysis is integral to cerebellar neurogenesis and pathogenesis of medulloblastoma. Cancer Metab 1:. [PubMed: 24078863]  [MGI Ref ID J:210113]

Ghashghaei HT; Weber J; Pevny L; Schmid R; Schwab MH; Lloyd KC; Eisenstat DD; Lai C; Anton ES. 2006. The role of neuregulin-ErbB4 interactions on the proliferation and organization of cells in the subventricular zone. Proc Natl Acad Sci U S A 103(6):1930-5. [PubMed: 16446434]  [MGI Ref ID J:106042]

Haj-Yasein NN; Vindedal GF; Eilert-Olsen M; Gundersen GA; Skare O; Laake P; Klungland A; Thoren AE; Burkhardt JM; Ottersen OP; Nagelhus EA. 2011. Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet. Proc Natl Acad Sci U S A 108(43):17815-20. [PubMed: 21990350]  [MGI Ref ID J:177412]

Han YG; Kim HJ; Dlugosz AA; Ellison DW; Gilbertson RJ; Alvarez-Buylla A. 2009. Dual and opposing roles of primary cilia in medulloblastoma development. Nat Med 15(9):1062-5. [PubMed: 19701203]  [MGI Ref ID J:154130]

Han YG; Spassky N; Romaguera-Ros M; Garcia-Verdugo JM; Aguilar A; Schneider-Maunoury S; Alvarez-Buylla A. 2008. Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells. Nat Neurosci 11(3):277-84. [PubMed: 18297065]  [MGI Ref ID J:135664]

Harris JA; Hirokawa KE; Sorensen SA; Gu H; Mills M; Ng LL; Bohn P; Mortrud M; Ouellette B; Kidney J; Smith KA; Dang C; Sunkin S; Bernard A; Oh SW; Madisen L; Zeng H. 2014. Anatomical characterization of Cre driver mice for neural circuit mapping and manipulation. Front Neural Circuits 8:76. [PubMed: 25071457]  [MGI Ref ID J:220523]

Hartman BH; Reh TA; Bermingham-McDonogh O. 2010. Notch signaling specifies prosensory domains via lateral induction in the developing mammalian inner ear. Proc Natl Acad Sci U S A 107(36):15792-7. [PubMed: 20798046]  [MGI Ref ID J:164376]

He Y; Hakvoort TB; Vermeulen JL; Labruyere WT; De Waart DR; Van Der Hel WS; Ruijter JM; Uylings HB; Lamers WH. 2010. Glutamine synthetase deficiency in murine astrocytes results in neonatal death. Glia 58(6):741-54. [PubMed: 20140959]  [MGI Ref ID J:162067]

Hegedus B; Banerjee D; Yeh TH; Rothermich S; Perry A; Rubin JB; Garbow JR; Gutmann DH. 2008. Preclinical cancer therapy in a mouse model of neurofibromatosis-1 optic glioma. Cancer Res 68(5):1520-8. [PubMed: 18316617]  [MGI Ref ID J:132860]

Higginbotham H; Guo J; Yokota Y; Umberger NL; Su CY; Li J; Verma N; Hirt J; Ghukasyan V; Caspary T; Anton ES. 2013. Arl13b-regulated cilia activities are essential for polarized radial glial scaffold formation. Nat Neurosci 16(8):1000-7. [PubMed: 23817546]  [MGI Ref ID J:203743]

Hong P; Jiang M; Li H. 2014. Functional requirement of dicer1 and miR-17-5p in reactive astrocyte proliferation after spinal cord injury in the mouse. Glia 62(12):2044-60. [PubMed: 25043492]  [MGI Ref ID J:214950]

Hsia HE; Kumar R; Luca R; Takeda M; Courchet J; Nakashima J; Wu S; Goebbels S; An W; Eickholt BJ; Polleux F; Rotin D; Wu H; Rossner MJ; Bagni C; Rhee JS; Brose N; Kawabe H. 2014. Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth. Proc Natl Acad Sci U S A 111(36):13205-10. [PubMed: 25157163]  [MGI Ref ID J:216394]

Hu H; Li J; Gagen CS; Gray NW; Zhang Z; Qi Y; Zhang P. 2011. Conditional knockout of protein O-mannosyltransferase 2 reveals tissue-specific roles of O-mannosyl glycosylation in brain development. J Comp Neurol 519(7):1320-37. [PubMed: 21452199]  [MGI Ref ID J:179356]

Hu J; Ho AL; Yuan L; Hu B; Hua S; Hwang SS; Zhang J; Hu T; Zheng H; Gan B; Wu G; Wang YA; Chin L; Depinho RA. 2013. From the Cover: Neutralization of terminal differentiation in gliomagenesis. Proc Natl Acad Sci U S A 110(36):14520-7. [PubMed: 23918370]  [MGI Ref ID J:200674]

Hu J; Popp R; Fromel T; Ehling M; Awwad K; Adams RH; Hammes HP; Fleming I. 2014. Muller glia cells regulate Notch signaling and retinal angiogenesis via the generation of 19,20-dihydroxydocosapentaenoic acid. J Exp Med 211(2):281-95. [PubMed: 24446488]  [MGI Ref ID J:208344]

Huang YY; Dai L; Gaines D; Droz-Rosario R; Lu H; Liu J; Shen Z. 2013. BCCIP suppresses tumor initiation but is required for tumor progression. Cancer Res 73(23):7122-33. [PubMed: 24145349]  [MGI Ref ID J:206526]

Huang YY; Lu H; Liu S; Droz-Rosario R; Shen Z. 2012. Requirement of mouse BCCIP for neural development and progenitor proliferation. PLoS One 7(1):e30638. [PubMed: 22292003]  [MGI Ref ID J:220928]

Huillard E; Hashizume R; Phillips JJ; Griveau A; Ihrie RA; Aoki Y; Nicolaides T; Perry A; Waldman T; McMahon M; Weiss WA; Petritsch C; James CD; Rowitch DH. 2012. Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy. Proc Natl Acad Sci U S A 109(22):8710-5. [PubMed: 22586120]  [MGI Ref ID J:184756]

Huse JT; Holland EC. 2009. Genetically engineered mouse models of brain cancer and the promise of preclinical testing. Brain Pathol 19(1):132-43. [PubMed: 19076778]  [MGI Ref ID J:173443]

Hwang WW; Salinas RD; Siu JJ; Kelley KW; Delgado RN; Paredes MF; Alvarez-Buylla A; Oldham MC; Lim DA. 2014. Distinct and separable roles for EZH2 in neurogenic astroglia. Elife 3:e02439. [PubMed: 24867641]  [MGI Ref ID J:213274]

Ihrie RA; Shah JK; Harwell CC; Levine JH; Guinto CD; Lezameta M; Kriegstein AR; Alvarez-Buylla A. 2011. Persistent sonic hedgehog signaling in adult brain determines neural stem cell positional identity. Neuron 71(2):250-62. [PubMed: 21791285]  [MGI Ref ID J:174685]

Isegawa K; Hirooka Y; Katsuki M; Kishi T; Sunagawa K. 2014. Angiotensin II type 1 receptor expression in astrocytes is upregulated leading to increased mortality in mice with myocardial infarction-induced heart failure. Am J Physiol Heart Circ Physiol 307(10):H1448-55. [PubMed: 25217656]  [MGI Ref ID J:218685]

Jaarsma D; van den Berg R; Wulf PS; van Erp S; Keijzer N; Schlager MA; de Graaff E; De Zeeuw CI; Pasterkamp RJ; Akhmanova A; Hoogenraad CC. 2014. A role for Bicaudal-D2 in radial cerebellar granule cell migration. Nat Commun 5:3411. [PubMed: 24614806]  [MGI Ref ID J:210236]

Julian E; Dave RK; Robson JP; Hallahan AR; Wainwright BJ. 2010. Canonical Notch signaling is not required for the growth of Hedgehog pathway-induced medulloblastoma. Oncogene 29(24):3465-76. [PubMed: 20418906]  [MGI Ref ID J:162028]

Kirsch M; Trautmann N; Ernst M; Hofmann HD. 2010. Involvement of gp130-associated cytokine signaling in Muller cell activation following optic nerve lesion. Glia 58(7):768-79. [PubMed: 20091786]  [MGI Ref ID J:167892]

Koo BK; Yoon MJ; Yoon KJ; Im SK; Kim YY; Kim CH; Suh PG; Jan YN; Kong YY. 2007. An obligatory role of mind bomb-1 in notch signaling of Mammalian development. PLoS ONE 2(11):e1221. [PubMed: 18043734]  [MGI Ref ID J:130369]

Kuang Y; Liu Q; Shu X; Zhang C; Huang N; Li J; Jiang M; Li H. 2012. Dicer1 and MiR-9 are required for proper Notch1 signaling and the Bergmann glial phenotype in the developing mouse cerebellum. Glia 60(11):1734-46. [PubMed: 22836445]  [MGI Ref ID J:187392]

Kunze A; Congreso MR; Hartmann C; Wallraff-Beck A; Huttmann K; Bedner P; Requardt R; Seifert G; Redecker C; Willecke K; Hofmann A; Pfeifer A; Theis M; Steinhauser C. 2009. Connexin expression by radial glia-like cells is required for neurogenesis in the adult dentate gyrus. Proc Natl Acad Sci U S A 106(27):11336-41. [PubMed: 19549869]  [MGI Ref ID J:150822]

Kwon CH; Zhao D; Chen J; Alcantara S; Li Y; Burns DK; Mason RP; Lee EY; Wu H; Parada LF. 2008. Pten haploinsufficiency accelerates formation of high-grade astrocytomas. Cancer Res 68(9):3286-94. [PubMed: 18451155]  [MGI Ref ID J:134611]

Lee N; Batt MK; Cronier BA; Jackson MC; Bruno Garza JL; Trinh DS; Mason CO; Spearry RP; Bhattacharya S; Robitz R; Nakafuku M; MacLennan AJ. 2013. Ciliary neurotrophic factor receptor regulation of adult forebrain neurogenesis. J Neurosci 33(3):1241-58. [PubMed: 23325260]  [MGI Ref ID J:193900]

Lesche R; Groszer M; Gao J; Wang Y; Messing A; Sun H; Liu X; Wu H. 2002. Cre/loxP-mediated inactivation of the murine Pten tumor suppressor gene. Genesis 32(2):148-9. [PubMed: 11857804]  [MGI Ref ID J:75117]

Li W; Huang R; Chen Z; Yan LJ; Simpkins JW; Yang SH. 2014. PTEN degradation after ischemic stroke: a double-edged sword. Neuroscience 274:153-61. [PubMed: 24875179]  [MGI Ref ID J:213269]

Li X; Newbern JM; Wu Y; Morgan-Smith M; Zhong J; Charron J; Snider WD. 2012. MEK Is a Key Regulator of Gliogenesis in the Developing Brain. Neuron 75(6):1035-50. [PubMed: 22998872]  [MGI Ref ID J:188328]

Li Y; Hibbs MA; Gard AL; Shylo NA; Yun K. 2012. Genome-wide analysis of N1ICD/RBPJ targets in vivo reveals direct transcriptional regulation of Wnt, SHH, and hippo pathway effectors by Notch1. Stem Cells 30(4):741-52. [PubMed: 22232070]  [MGI Ref ID J:190509]

Li Y; Lim S; Hoffman D; Aspenstrom P; Federoff HJ; Rempe DA. 2009. HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport. J Cell Biol 185(6):1065-81. [PubMed: 19528298]  [MGI Ref ID J:150420]

Li Y; Luikart BW; Birnbaum S; Chen J; Kwon CH; Kernie SG; Bassel-Duby R; Parada LF. 2008. TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment. Neuron 59(3):399-412. [PubMed: 18701066]  [MGI Ref ID J:147252]

Liebmann M; Stahr A; Guenther M; Witte OW; Frahm C. 2013. Astrocytic Cx43 and Cx30 differentially modulate adult neurogenesis in mice. Neurosci Lett 545:40-5. [PubMed: 23618652]  [MGI Ref ID J:201114]

Lim DA; Huang YC; Swigut T; Mirick AL; Garcia-Verdugo JM; Wysocka J; Ernst P; Alvarez-Buylla A. 2009. Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells. Nature 458(7237):529-33. [PubMed: 19212323]  [MGI Ref ID J:147104]

Lin JH; Lou N; Kang N; Takano T; Hu F; Han X; Xu Q; Lovatt D; Torres A; Willecke K; Yang J; Kang J; Nedergaard M. 2008. A central role of connexin 43 in hypoxic preconditioning. J Neurosci 28(3):681-95. [PubMed: 18199768]  [MGI Ref ID J:149339]

Lin Y; Chen L; Lin C; Luo Y; Tsai RY; Wang F. 2009. Neuron-derived FGF9 is essential for scaffold formation of Bergmann radial fibers and migration of granule neurons in the cerebellum. Dev Biol 329(1):44-54. [PubMed: 19232523]  [MGI Ref ID J:148042]

Liu C; Sage JC; Miller MR; Verhaak RG; Hippenmeyer S; Vogel H; Foreman O; Bronson RT; Nishiyama A; Luo L; Zong H. 2011. Mosaic analysis with double markers reveals tumor cell of origin in glioma. Cell 146(2):209-21. [PubMed: 21737130]  [MGI Ref ID J:174616]

Liu W; Zhou H; Liu L; Zhao C; Deng Y; Chen L; Wu L; Mandrycky N; McNabb CT; Peng Y; Fuchs PN; Lu J; Sheen V; Qiu M; Mao M; Richard Lu Q. 2015. Disruption of neurogenesis and cortical development in transgenic mice misexpressing Olig2, a gene in the Down syndrome critical region. Neurobiol Dis 77:106-16. [PubMed: 25747816]  [MGI Ref ID J:221129]

Louvi A; Chen L; Two AM; Zhang H; Min W; Gunel M. 2011. Loss of cerebral cavernous malformation 3 (Ccm3) in neuroglia leads to CCM and vascular pathology. Proc Natl Acad Sci U S A 108(9):3737-42. [PubMed: 21321212]  [MGI Ref ID J:170480]

Louvi A; Nishimura S; Gunel M. 2014. Ccm3, a gene associated with cerebral cavernous malformations, is required for neuronal migration. Development 141(6):1404-15. [PubMed: 24595293]  [MGI Ref ID J:208651]

Luikart BW; Nef S; Virmani T; Lush ME; Liu Y; Kavalali ET; Parada LF. 2005. TrkB has a cell-autonomous role in the establishment of hippocampal Schaffer collateral synapses. J Neurosci 25(15):3774-86. [PubMed: 15829629]  [MGI Ref ID J:98613]

Lush ME; Li Y; Kwon CH; Chen J; Parada LF. 2008. Neurofibromin is required for barrel formation in the mouse somatosensory cortex. J Neurosci 28(7):1580-7. [PubMed: 18272679]  [MGI Ref ID J:132220]

Lush ME; Ma L; Parada LF. 2005. TrkB signaling regulates the developmental maturation of the somatosensory cortex. Int J Dev Neurosci 23(6):523-36. [PubMed: 16009525]  [MGI Ref ID J:103935]

Ma L; Harada T; Harada C; Romero M; Hebert JM; McConnell SK; Parada LF. 2002. Neurotrophin-3 is required for appropriate establishment of thalamocortical connections. Neuron 36(4):623-34. [PubMed: 12441052]  [MGI Ref ID J:81563]

Ma S; Kwon HJ; Huang Z. 2012. Ric-8a, a guanine nucleotide exchange factor for heterotrimeric G proteins, regulates bergmann glia-basement membrane adhesion during cerebellar foliation. J Neurosci 32(43):14979-93. [PubMed: 23100420]  [MGI Ref ID J:191222]

Madisen L; Zwingman TA; Sunkin SM; Oh SW; Zariwala HA; Gu H; Ng LL; Palmiter RD; Hawrylycz MJ; Jones AR; Lein ES; Zeng H. 2010. A robust and high-throughput Cre reporting and characterization system for the whole mouse brain. Nat Neurosci 13(1):133-40. [PubMed: 20023653]  [MGI Ref ID J:155793]

Magnotti LM; Goodenough DA; Paul DL. 2011. Deletion of oligodendrocyte Cx32 and astrocyte Cx43 causes white matter vacuolation, astrocyte loss and early mortality. Glia 59(7):1064-74. [PubMed: 21538560]  [MGI Ref ID J:171651]

Magri L; Cominelli M; Cambiaghi M; Cursi M; Leocani L; Minicucci F; Poliani PL; Galli R. 2013. Timing of mTOR activation affects tuberous sclerosis complex neuropathology in mouse models. Dis Model Mech 6(5):1185-97. [PubMed: 23744272]  [MGI Ref ID J:201333]

Maire CL; Ramkissoon S; Hayashi M; Haidar S; Ramkissoon L; DiTomaso E; Ligon KL. 2014. Pten loss in Olig2 expressing neural progenitor cells and oligodendrocytes leads to interneuron dysplasia and leukodystrophy. Stem Cells 32(1):313-26. [PubMed: 24395742]  [MGI Ref ID J:206870]

Malatesta P; Hack MA; Hartfuss E; Kettenmann H; Klinkert W; Kirchhoff F; Gotz M. 2003. Neuronal or glial progeny: regional differences in radial glia fate. Neuron 37(5):751-64. [PubMed: 12628166]  [MGI Ref ID J:83041]

Marumoto T; Tashiro A; Friedmann-Morvinski D; Scadeng M; Soda Y; Gage FH; Verma IM. 2009. Development of a novel mouse glioma model using lentiviral vectors. Nat Med 15(1):110-6. [PubMed: 19122659]  [MGI Ref ID J:146551]

May D; Tress O; Seifert G; Willecke K. 2013. Connexin47 protein phosphorylation and stability in oligodendrocytes depend on expression of Connexin43 protein in astrocytes. J Neurosci 33(18):7985-96. [PubMed: 23637189]  [MGI Ref ID J:197146]

Mederacke I; Hsu CC; Troeger JS; Huebener P; Mu X; Dapito DH; Pradere JP; Schwabe RF. 2013. Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology. Nat Commun 4:2823. [PubMed: 24264436]  [MGI Ref ID J:205330]

Michelotti GA; Xie G; Swiderska M; Choi SS; Karaca G; Kruger L; Premont R; Yang L; Syn WK; Metzger D; Diehl AM. 2013. Smoothened is a master regulator of adult liver repair. J Clin Invest 123(6):2380-94. [PubMed: 23563311]  [MGI Ref ID J:201461]

Mietzsch U; McKenna J 3rd; Reith RM; Way SW; Gambello MJ. 2013. Comparative analysis of Tsc1 and Tsc2 single and double radial glial cell mutants. J Comp Neurol 521(16):3817-31. [PubMed: 23749404]  [MGI Ref ID J:203971]

Milla LA; Arros A; Espinoza N; Remke M; Kool M; Taylor MD; Pfister SM; Wainwright BJ; Palma V. 2014. Neogenin1 is a Sonic Hedgehog target in medulloblastoma and is necessary for cell cycle progression. Int J Cancer 134(1):21-31. [PubMed: 23775842]  [MGI Ref ID J:203346]

Mokalled MH; Johnson A; Kim Y; Oh J; Olson EN. 2010. Myocardin-related transcription factors regulate the Cdk5/Pctaire1 kinase cascade to control neurite outgrowth, neuronal migration and brain development. Development 137(14):2365-74. [PubMed: 20534669]  [MGI Ref ID J:161853]

Monteggia LM; Luikart B; Barrot M; Theobold D; Malkovska I; Nef S; Parada LF; Nestler EJ. 2007. Brain-derived neurotrophic factor conditional knockouts show gender differences in depression-related behaviors. Biol Psychiatry 61(2):187-97. [PubMed: 16697351]  [MGI Ref ID J:129526]

Montgomery RL; Hsieh J; Barbosa AC; Richardson JA; Olson EN. 2009. Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development. Proc Natl Acad Sci U S A 106(19):7876-81. [PubMed: 19380719]  [MGI Ref ID J:148408]

Moon BC; Hernandez-Ono A; Stiles B; Wu H; Ginsberg HN. 2012. Apolipoprotein B secretion is regulated by hepatic triglyceride, and not insulin, in a model of increased hepatic insulin signaling. Arterioscler Thromb Vasc Biol 32(2):236-46. [PubMed: 22155452]  [MGI Ref ID J:195966]

Moore SA; Saito F; Chen J; Michele DE; Henry MD; Messing A; Cohn RD; Ross-Barta SE; Westra S; Williamson RA; Hoshi T; Campbell KP. 2002. Deletion of brain dystroglycan recapitulates aspects of congenital muscular dystrophy. Nature 418(6896):422-5. [PubMed: 12140559]  [MGI Ref ID J:86901]

Muller Smith K; Fagel DM; Stevens HE; Rabenstein RL; Maragnoli ME; Ohkubo Y; Picciotto MR; Schwartz ML; Vaccarino FM. 2008. Deficiency in inhibitory cortical interneurons associates with hyperactivity in fibroblast growth factor receptor 1 mutant mice. Biol Psychiatry 63(10):953-62. [PubMed: 17988653]  [MGI Ref ID J:139827]

Muller Smith K; Williamson TL; Schwartz ML; Vaccarino FM. 2012. Impaired motor coordination and disrupted cerebellar architecture in Fgfr1 and Fgfr2 double knockout mice. Brain Res 1460:12-24. [PubMed: 22578469]  [MGI Ref ID J:186443]

Nakase T; Fushiki S; Sohl G; Theis M; Willecke K; Naus CC. 2003. Neuroprotective role of astrocytic gap junctions in ischemic stroke. Cell Commun Adhes 10(4-6):413-7. [PubMed: 14681050]  [MGI Ref ID J:103075]

Nakase T; Sohl G; Theis M; Willecke K; Naus CC. 2004. Increased apoptosis and inflammation after focal brain ischemia in mice lacking connexin43 in astrocytes. Am J Pathol 164(6):2067-75. [PubMed: 15161641]  [MGI Ref ID J:91068]

Namekata K; Harada C; Taya C; Guo X; Kimura H; Parada LF; Harada T. 2010. Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex. Proc Natl Acad Sci U S A 107(16):7586-91. [PubMed: 20368433]  [MGI Ref ID J:159284]

Natarajan S; Li Y; Miller EE; Shih DJ; Taylor MD; Stearns TM; Bronson RT; Ackerman SL; Yoon JK; Yun K. 2013. Notch1-induced brain tumor models the sonic hedgehog subgroup of human medulloblastoma. Cancer Res 73(17):5381-90. [PubMed: 23852537]  [MGI Ref ID J:201833]

Nijboer CH; Heijnen CJ; Degos V; Willemen HL; Gressens P; Kavelaars A. 2013. Astrocyte GRK2 as a novel regulator of glutamate transport and brain damage. Neurobiol Dis 54:206-15. [PubMed: 23313319]  [MGI Ref ID J:197760]

Nishino J; Kim S; Zhu Y; Zhu H; Morrison SJ. 2013. A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties. Elife 2:e00924. [PubMed: 24192035]  [MGI Ref ID J:207231]

Niu W; Zang T; Zou Y; Fang S; Smith DK; Bachoo R; Zhang CL. 2013. In vivo reprogramming of astrocytes to neuroblasts in the adult brain. Nat Cell Biol 15(10):1164-75. [PubMed: 24056302]  [MGI Ref ID J:201817]

Noell S; Wolburg-Buchholz K; Mack AF; Beedle AM; Satz JS; Campbell KP; Wolburg H; Fallier-Becker P. 2011. Evidence for a role of dystroglycan regulating the membrane architecture of astroglial endfeet. Eur J Neurosci 33(12):2179-86. [PubMed: 21501259]  [MGI Ref ID J:176372]

Okamoto R; Ito M; Suzuki N; Kongo M; Moriki N; Saito H; Tsumura H; Imanaka-Yoshida K; Kimura K; Mizoguchi A; Hartshorne DJ; Nakano T. 2005. The targeted disruption of the MYPT1 gene results in embryonic lethality Transgenic Res 14(3):337-40. [PubMed: 16145842]  [MGI Ref ID J:100069]

Paik JH; Ding Z; Narurkar R; Ramkissoon S; Muller F; Kamoun WS; Chae SS; Zheng H; Ying H; Mahoney J; Hiller D; Jiang S; Protopopov A; Wong WH; Chin L; Ligon KL; DePinho RA. 2009. FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell 5(5):540-53. [PubMed: 19896444]  [MGI Ref ID J:154024]

Palmer CJ; Galan-Caridad JM; Weisberg SP; Lei L; Esquilin JM; Croft GF; Wainwright B; Canoll P; Owens DM; Reizis B. 2014. Zfx facilitates tumorigenesis caused by activation of the Hedgehog pathway. Cancer Res 74(20):5914-24. [PubMed: 25164012]  [MGI Ref ID J:216695]

Papagiannakopoulos T; Friedmann-Morvinski D; Neveu P; Dugas JC; Gill RM; Huillard E; Liu C; Zong H; Rowitch DH; Barres BA; Verma IM; Kosik KS. 2012. Pro-neural miR-128 is a glioma tumor suppressor that targets mitogenic kinases. Oncogene 31(15):1884-95. [PubMed: 21874051]  [MGI Ref ID J:186143]

Park HJ; Hong M; Bronson RT; Israel MA; Frankel WN; Yun K. 2013. Elevated id2 expression results in precocious neural stem cell depletion and abnormal brain development. Stem Cells 31(5):1010-21. [PubMed: 23390122]  [MGI Ref ID J:196308]

Pei Y; Brun SN; Markant SL; Lento W; Gibson P; Taketo MM; Giovannini M; Gilbertson RJ; Wechsler-Reya RJ. 2012. WNT signaling increases proliferation and impairs differentiation of stem cells in the developing cerebellum. Development 139(10):1724-33. [PubMed: 22461560]  [MGI Ref ID J:184015]

Peng X; Lin Q; Liu Y; Jin Y; Druso JE; Antonyak MA; Guan JL; Cerione RA. 2013. Inactivation of Cdc42 in embryonic brain results in hydrocephalus with ependymal cell defects in mice. Protein Cell 4(3):231-42. [PubMed: 23150167]  [MGI Ref ID J:197886]

Platero-Luengo A; Gonzalez-Granero S; Duran R; Diaz-Castro B; Piruat JI; Garcia-Verdugo JM; Pardal R; Lopez-Barneo J. 2014. An o2-sensitive glomus cell-stem cell synapse induces carotid body growth in chronic hypoxia. Cell 156(1-2):291-303. [PubMed: 24439383]  [MGI Ref ID J:205562]

Porlan E; Marti-Prado B; Morante-Redolat JM; Consiglio A; Delgado AC; Kypta R; Lopez-Otin C; Kirstein M; Farinas I. 2014. MT5-MMP regulates adult neural stem cell functional quiescence through the cleavage of N-cadherin. Nat Cell Biol 16(7):629-38. [PubMed: 24952463]  [MGI Ref ID J:213556]

Poschl J; Grammel D; Dorostkar MM; Kretzschmar HA; Schuller U. 2013. Constitutive activation of beta-catenin in neural progenitors results in disrupted proliferation and migration of neurons within the central nervous system. Dev Biol 374(2):319-32. [PubMed: 23237957]  [MGI Ref ID J:193531]

Price RL; Song J; Bingmer K; Kim TH; Yi JY; Nowicki MO; Mo X; Hollon T; Murnan E; Alvarez-Breckenridge C; Fernandez S; Kaur B; Rivera A; Oglesbee M; Cook C; Chiocca EA; Kwon CH. 2013. Cytomegalovirus contributes to glioblastoma in the context of tumor suppressor mutations. Cancer Res 73(11):3441-50. [PubMed: 23729642]  [MGI Ref ID J:199096]

Raj DD; Jaarsma D; Holtman IR; Olah M; Ferreira FM; Schaafsma W; Brouwer N; Meijer MM; de Waard MC; van der Pluijm I; Brandt R; Kreft KL; Laman JD; de Haan G; Biber KP; Hoeijmakers JH; Eggen BJ; Boddeke HW. 2014. Priming of microglia in a DNA-repair deficient model of accelerated aging. Neurobiol Aging 35(9):2147-60. [PubMed: 24799273]  [MGI Ref ID J:213229]

Ren Z; Chen X; Yang J; Kress BT; Tong J; Liu H; Takano T; Zhao Y; Nedergaard M. 2013. Improved axonal regeneration after spinal cord injury in mice with conditional deletion of ephrin B2 under the GFAP promoter. Neuroscience 241:89-99. [PubMed: 23518227]  [MGI Ref ID J:201358]

Requardt RP; Kaczmarczyk L; Dublin P; Wallraff-Beck A; Mikeska T; Degen J; Waha A; Steinhauser C; Willecke K; Theis M. 2009. Quality control of astrocyte-directed Cre transgenic mice: the benefits of a direct link between loss of gene expression and reporter activation. Glia 57(6):680-92. [PubMed: 18942753]  [MGI Ref ID J:156217]

Rhee KD; Nusinowitz S; Chao K; Yu F; Bok D; Yang XJ. 2013. CNTF-mediated protection of photoreceptors requires initial activation of the cytokine receptor gp130 in Muller glial cells. Proc Natl Acad Sci U S A 110(47):E4520-9. [PubMed: 24191003]  [MGI Ref ID J:202986]

Robel S; Buckingham SC; Boni JL; Campbell SL; Danbolt NC; Riedemann T; Sutor B; Sontheimer H. 2015. Reactive astrogliosis causes the development of spontaneous seizures. J Neurosci 35(8):3330-45. [PubMed: 25716834]  [MGI Ref ID J:219851]

Robel S; Mori T; Zoubaa S; Schlegel J; Sirko S; Faissner A; Goebbels S; Dimou L; Gotz M. 2009. Conditional deletion of beta1-integrin in astroglia causes partial reactive gliosis. Glia 57(15):1630-47. [PubMed: 19373938]  [MGI Ref ID J:156199]

Rouach N; Koulakoff A; Abudara V; Willecke K; Giaume C. 2008. Astroglial metabolic networks sustain hippocampal synaptic transmission. Science 322(5907):1551-5. [PubMed: 19056987]  [MGI Ref ID J:142034]

Samuels IS; Karlo JC; Faruzzi AN; Pickering K; Herrup K; Sweatt JD; Saitta SC; Landreth GE. 2008. Deletion of ERK2 mitogen-activated protein kinase identifies its key roles in cortical neurogenesis and cognitive function. J Neurosci 28(27):6983-95. [PubMed: 18596172]  [MGI Ref ID J:137882]

Sanchez-Ortiz E; Cho W; Nazarenko I; Mo W; Chen J; Parada LF. 2014. NF1 regulation of RAS/ERK signaling is required for appropriate granule neuron progenitor expansion and migration in cerebellar development. Genes Dev 28(21):2407-20. [PubMed: 25367036]  [MGI Ref ID J:217419]

Sathyamurthy A; Yin DM; Barik A; Shen C; Bean JC; Figueiredo D; She JX; Xiong WC; Mei L. 2015. ERBB3-mediated regulation of Bergmann glia proliferation in cerebellar lamination. Development 142(3):522-32. [PubMed: 25564653]  [MGI Ref ID J:217671]

Satz JS; Ostendorf AP; Hou S; Turner A; Kusano H; Lee JC; Turk R; Nguyen H; Ross-Barta SE; Westra S; Hoshi T; Moore SA; Campbell KP. 2010. Distinct functions of glial and neuronal dystroglycan in the developing and adult mouse brain. J Neurosci 30(43):14560-72. [PubMed: 20980614]  [MGI Ref ID J:166208]

Satz JS; Philp AR; Nguyen H; Kusano H; Lee J; Turk R; Riker MJ; Hernandez J; Weiss RM; Anderson MG; Mullins RF; Moore SA; Stone EM; Campbell KP. 2009. Visual impairment in the absence of dystroglycan. J Neurosci 29(42):13136-46. [PubMed: 19846701]  [MGI Ref ID J:158199]

Schuller U; Heine VM; Mao J; Kho AT; Dillon AK; Han YG; Huillard E; Sun T; Ligon AH; Qian Y; Ma Q; Alvarez-Buylla A; McMahon AP; Rowitch DH; Ligon KL. 2008. Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. Cancer Cell 14(2):123-34. [PubMed: 18691547]  [MGI Ref ID J:139574]

Shao W; Zhang SZ; Tang M; Zhang XH; Zhou Z; Yin YQ; Zhou QB; Huang YY; Liu YJ; Wawrousek E; Chen T; Li SB; Xu M; Zhou JN; Hu G; Zhou JW. 2013. Suppression of neuroinflammation by astrocytic dopamine D2 receptors via alphaB-crystallin. Nature 494(7435):90-4. [PubMed: 23242137]  [MGI Ref ID J:194407]

Sherrod M; Davis DR; Zhou X; Cassell MD; Sigmund CD. 2005. Glial-specific ablation of angiotensinogen lowers arterial pressure in renin and angiotensinogen transgenic mice. Am J Physiol Regul Integr Comp Physiol 289(6):R1763-9. [PubMed: 16109805]  [MGI Ref ID J:130651]

Silvis MR; Kreger BT; Lien WH; Klezovitch O; Rudakova GM; Camargo FD; Lantz DM; Seykora JT; Vasioukhin V. 2011. alpha-catenin is a tumor suppressor that controls cell accumulation by regulating the localization and activity of the transcriptional coactivator Yap1. Sci Signal 4(174):ra33. [PubMed: 21610251]  [MGI Ref ID J:185995]

Smith KM; Maragnoli ME; Phull PM; Tran KM; Choubey L; Vaccarino FM. 2014. Fgfr1 inactivation in the mouse telencephalon results in impaired maturation of interneurons expressing parvalbumin. PLoS One 9(8):e103696. [PubMed: 25116473]  [MGI Ref ID J:218988]

Smith KM; Ohkubo Y; Maragnoli ME; Rasin MR; Schwartz ML; Sestan N; Vaccarino FM. 2006. Midline radial glia translocation and corpus callosum formation require FGF signaling. Nat Neurosci 9(6):787-97. [PubMed: 16715082]  [MGI Ref ID J:110263]

Soda Y; Marumoto T; Friedmann-Morvinski D; Soda M; Liu F; Michiue H; Pastorino S; Yang M; Hoffman RM; Kesari S; Verma IM. 2011. From the Cover: Feature Article: Transdifferentiation of glioblastoma cells into vascular endothelial cells. Proc Natl Acad Sci U S A 108(11):4274-80. [PubMed: 21262804]  [MGI Ref ID J:170761]

Spassky N; Han YG; Aguilar A; Strehl L; Besse L; Laclef C; Ros MR; Garcia-Verdugo JM; Alvarez-Buylla A. 2008. Primary cilia are required for cerebellar development and Shh-dependent expansion of progenitor pool. Dev Biol 317(1):246-59. [PubMed: 18353302]  [MGI Ref ID J:136079]

Stalnaker SH; Aoki K; Lim JM; Porterfield M; Liu M; Satz JS; Buskirk S; Xiong Y; Zhang P; Campbell KP; Hu H; Live D; Tiemeyer M; Wells L. 2011. Glycomic analyses of mouse models of congenital muscular dystrophy. J Biol Chem 286(24):21180-90. [PubMed: 21460210]  [MGI Ref ID J:173659]

Stevens HE; Smith KM; Maragnoli ME; Fagel D; Borok E; Shanabrough M; Horvath TL; Vaccarino FM. 2010. Fgfr2 is required for the development of the medial prefrontal cortex and its connections with limbic circuits. J Neurosci 30(16):5590-602. [PubMed: 20410112]  [MGI Ref ID J:159839]

Tanaka M; Yamaguchi K; Tatsukawa T; Theis M; Willecke K; Itohara S. 2008. Connexin43 and bergmann glial gap junctions in cerebellar function. Front Neurosci 2(2):225-33. [PubMed: 19225596]  [MGI Ref ID J:159159]

Theis M; Jauch R; Zhuo L; Speidel D; Wallraff A; Doring B; Frisch C; Sohl G; Teubner B; Euwens C; Huston J; Steinhauser C; Messing A; Heinemann U; Willecke K. 2003. Accelerated hippocampal spreading depression and enhanced locomotory activity in mice with astrocyte-directed inactivation of connexin43. J Neurosci 23(3):766-76. [PubMed: 12574405]  [MGI Ref ID J:81921]

Theis M; Speidel D; Willecke K. 2004. Astrocyte cultures from conditional connexin43-deficient mice. Glia 46(2):130-41. [PubMed: 15042581]  [MGI Ref ID J:156062]

Tong CK; Han YG; Shah JK; Obernier K; Guinto CD; Alvarez-Buylla A. 2014. Primary cilia are required in a unique subpopulation of neural progenitors. Proc Natl Acad Sci U S A 111(34):12438-43. [PubMed: 25114218]  [MGI Ref ID J:213914]

Tsai PT; Ohab JJ; Kertesz N; Groszer M; Matter C; Gao J; Liu X; Wu H; Carmichael ST. 2006. A critical role of erythropoietin receptor in neurogenesis and post-stroke recovery. J Neurosci 26(4):1269-74. [PubMed: 16436614]  [MGI Ref ID J:104816]

Tuoc TC; Boretius S; Sansom SN; Pitulescu ME; Frahm J; Livesey FJ; Stoykova A. 2013. Chromatin Regulation by BAF170 Controls Cerebral Cortical Size and Thickness. Dev Cell 25(3):256-69. [PubMed: 23643363]  [MGI Ref ID J:197141]

Tuoc TC; Radyushkin K; Tonchev AB; Pinon MC; Ashery-Padan R; Molnar Z; Davidoff MS; Stoykova A. 2009. Selective cortical layering abnormalities and behavioral deficits in cortex-specific Pax6 knock-out mice. J Neurosci 29(26):8335-49. [PubMed: 19571125]  [MGI Ref ID J:150808]

Wallraff A; Kohling R; Heinemann U; Theis M; Willecke K; Steinhauser C. 2006. The impact of astrocytic gap junctional coupling on potassium buffering in the hippocampus. J Neurosci 26(20):5438-47. [PubMed: 16707796]  [MGI Ref ID J:108703]

Wallraff A; Odermatt B; Willecke K; Steinhauser C. 2004. Distinct types of astroglial cells in the hippocampus differ in gap junction coupling. Glia 48(1):36-43. [PubMed: 15326613]  [MGI Ref ID J:156058]

Wang C; Liang CC; Bian ZC; Zhu Y; Guan JL. 2013. FIP200 is required for maintenance and differentiation of postnatal neural stem cells. Nat Neurosci 16(5):532-42. [PubMed: 23542691]  [MGI Ref ID J:197614]

Wang Y; Yang J; Zheng H; Tomasek GJ; Zhang P; McKeever PE; Lee EY; Zhu Y. 2009. Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model. Cancer Cell 15(6):514-26. [PubMed: 19477430]  [MGI Ref ID J:149662]

Way SW; McKenna J rd; Mietzsch U; Reith RM; Wu HC; Gambello MJ. 2009. Loss of Tsc2 in radial glia models the brain pathology of tuberous sclerosis complex in the mouse. Hum Mol Genet 18(7):1252-65. [PubMed: 19150975]  [MGI Ref ID J:146159]

Way SW; Rozas NS; Wu HC; McKenna J 3rd; Reith RM; Hashmi SS; Dash PK; Gambello MJ. 2012. The differential effects of prenatal and/or postnatal rapamycin on neurodevelopmental defects and cognition in a neuroglial mouse model of tuberous sclerosis complex. Hum Mol Genet 21(14):3226-36. [PubMed: 22532572]  [MGI Ref ID J:185369]

Xu D; Borges GR; Davis DR; Agassandian K; Sequeira Lopez ML; Gomez RA; Cassell MD; Grobe JL; Sigmund CD. 2010. Neuron- or Glial-Specific Ablation of Secreted Renin Does Not Affect Renal Renin, Baseline Arterial Pressure or Metabolism. Physiol Genomics :. [PubMed: 21189370]  [MGI Ref ID J:168753]

Xu G; Green CC; Fromholt SE; Borchelt DR. 2012. Reduction of low-density lipoprotein receptor-related protein (LRP1) in hippocampal neurons does not proportionately reduce, or otherwise alter, amyloid deposition in APPswe/PS1dE9 transgenic mice. Alzheimers Res Ther 4(2):12. [PubMed: 22537779]  [MGI Ref ID J:190171]

Yang JH; Wada A; Yoshida K; Miyoshi Y; Sayano T; Esaki K; Kinoshita MO; Tomonaga S; Azuma N; Watanabe M; Hamase K; Zaitsu K; Machida T; Messing A; Itohara S; Hirabayashi Y; Furuya S. 2010. Brain-specific Phgdh deletion reveals a pivotal role for L-serine biosynthesis in controlling the level of D-serine, an N-methyl-D-aspartate receptor co-agonist, in adult brain. J Biol Chem 285(53):41380-90. [PubMed: 20966073]  [MGI Ref ID J:167572]

Yang L; Jung Y; Omenetti A; Witek RP; Choi S; Vandongen HM; Huang J; Alpini GD; Diehl AM. 2008. Fate-mapping evidence that hepatic stellate cells are epithelial progenitors in adult mouse livers. Stem Cells 26(8):2104-13. [PubMed: 18511600]  [MGI Ref ID J:201713]

Yang ZJ; Ellis T; Markant SL; Read TA; Kessler JD; Bourboulas M; Schuller U; Machold R; Fishell G; Rowitch DH; Wainwright BJ; Wechsler-Reya RJ. 2008. Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. Cancer Cell 14(2):135-45. [PubMed: 18691548]  [MGI Ref ID J:139573]

Yingling J; Youn YH; Darling D; Toyo-Oka K; Pramparo T; Hirotsune S; Wynshaw-Boris A. 2008. Neuroepithelial stem cell proliferation requires LIS1 for precise spindle orientation and symmetric division. Cell 132(3):474-86. [PubMed: 18267077]  [MGI Ref ID J:135521]

Yokota Y; Eom TY; Stanco A; Kim WY; Rao S; Snider WD; Anton ES. 2010. Cdc42 and Gsk3 modulate the dynamics of radial glial growth, inter-radial glial interactions and polarity in the developing cerebral cortex. Development 137(23):4101-10. [PubMed: 21062867]  [MGI Ref ID J:166773]

Yokota Y; Kim WY; Chen Y; Wang X; Stanco A; Komuro Y; Snider W; Anton ES. 2009. The adenomatous polyposis coli protein is an essential regulator of radial glial polarity and construction of the cerebral cortex. Neuron 61(1):42-56. [PubMed: 19146812]  [MGI Ref ID J:147307]

Yoon KJ; Koo BK; Im SK; Jeong HW; Ghim J; Kwon MC; Moon JS; Miyata T; Kong YY. 2008. Mind bomb 1-expressing intermediate progenitors generate notch signaling to maintain radial glial cells. Neuron 58(4):519-31. [PubMed: 18498734]  [MGI Ref ID J:145294]

Youn YH; Pramparo T; Hirotsune S; Wynshaw-Boris A. 2009. Distinct dose-dependent cortical neuronal migration and neurite extension defects in Lis1 and Ndel1 mutant mice. J Neurosci 29(49):15520-30. [PubMed: 20007476]  [MGI Ref ID J:156181]

Yue Q; Groszer M; Gil JS; Berk AJ; Messing A; Wu H; Liu X. 2005. PTEN deletion in Bergmann glia leads to premature differentiation and affects laminar organization. Development 132(14):3281-91. [PubMed: 15944184]  [MGI Ref ID J:100428]

Yue T; Xian K; Hurlock E; Xin M; Kernie SG; Parada LF; Lu QR. 2006. A critical role for dorsal progenitors in cortical myelination. J Neurosci 26(4):1275-80. [PubMed: 16436615]  [MGI Ref ID J:105071]

Zhang C; Ge X; Liu Q; Jiang M; Li MW; Li H. 2015. MicroRNA-mediated non-cell-autonomous regulation of cortical radial glial transformation revealed by a Dicer1 knockout mouse model. Glia 63(5):860-76. [PubMed: 25643827]  [MGI Ref ID J:220852]

Zhang J; Dublin P; Griemsmann S; Klein A; Brehm R; Bedner P; Fleischmann BK; Steinhauser C; Theis M. 2013. Germ-line recombination activity of the widely used hGFAP-Cre and nestin-Cre transgenes. PLoS One 8(12):e82818. [PubMed: 24349371]  [MGI Ref ID J:211152]

Zheng H; Ying H; Yan H; Kimmelman AC; Hiller DJ; Chen AJ; Perry SR; Tonon G; Chu GC; Ding Z; Stommel JM; Dunn KL; Wiedemeyer R; You MJ; Brennan C; Wang YA; Ligon KL; Wong WH; Chin L; DePinho RA. 2008. p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation. Nature 455(7216):1129-33. [PubMed: 18948956]  [MGI Ref ID J:140704]

Zhu Y; Guignard F; Zhao D; Liu L; Burns DK; Mason RP; Messing A; Parada LF. 2005. Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma. Cancer Cell 8(2):119-30. [PubMed: 16098465]  [MGI Ref ID J:101868]

Zhu Y; Harada T; Liu L; Lush ME; Guignard F; Harada C; Burns DK; Bajenaru ML; Gutmann DH; Parada LF. 2005. Inactivation of NF1 in CNS causes increased glial progenitor proliferation and optic glioma formation. Development 132(24):5577-88. [PubMed: 16314489]  [MGI Ref ID J:104342]

Zou Y; Niu W; Qin S; Downes M; Burns DK; Zhang CL. 2012. The nuclear receptor TLX is required for gliomagenesis within the adult neurogenic niche. Mol Cell Biol 32(23):4811-20. [PubMed: 23028043]  [MGI Ref ID J:192734]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX11

Colony Maintenance

Breeding & HusbandryThe strain is maintained as a hemizygote on the FVB/N background.
Mating SystemNoncarrier x Hemizygote         (Female x Male)   25-OCT-08
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $239.00Female or MaleHemizygous for Tg(GFAP-cre)25Mes  
Price per Pair (US dollars $)Pair Genotype
$313.00Hemizygous for Tg(GFAP-cre)25Mes x Noncarrier  
$313.00Noncarrier x Hemizygous for Tg(GFAP-cre)25Mes  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $310.70Female or MaleHemizygous for Tg(GFAP-cre)25Mes  
Price per Pair (US dollars $)Pair Genotype
$406.90Hemizygous for Tg(GFAP-cre)25Mes x Noncarrier  
$406.90Noncarrier x Hemizygous for Tg(GFAP-cre)25Mes  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

   001800 FVB/NJ
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use

General Terms and Conditions

Contact information

General inquiries regarding Terms of Use

Contracts Administration


JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty


In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.