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| Homozygotes for this transgene are not viable. Hemizygotes express Cre recombinase under the control of the human glial fibrillary acidic protein promoter (GFAP). When crossed with a strain containing loxP site flanked sequence of interest, Cre-mediated recombination results in tissue-specific deletion of the target, and recombination occurs primarily in the central nervous system, affecting astrocytes, oligodendroglia, ependyma and some neurons. This mutant mouse strain represents an effective tool for generating central nervous system specific-targeted mutants. | |||||||||||||||
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Description
Strain Information
Former Names FVB-Tg(GFAP-cre)25Mes (Changed: 15-DEC-04 ) Type Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Mating System Noncarrier x Hemizygote (Female x Male) 25-OCT-08 Species laboratory mouse Generation N?+1pN19 (23-JAN-12)
Generation DefinitionsDonating Investigator Dr. Albee Messing, University of Wisconsin-Madison Description
Mice hemizygous for the transgenic insert are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Mice that are homozygous for the transgene are not viable. This transgenic mouse strain expresses Cre recombinase under the control of the human glial fibrillary acidic protein promoter (GFAP). When crossed with a strain containing loxP site flanked sequence of interest, Cre-mediated recombination results in tissue-specific deletion of the target. Recombination occurs primarily in the central nervous system, affecting astrocytes, oligodendroglia, ependyma and some neurons. Expression activity is also present in periportal cells of the liver. Developmental onset of transgene expression occurs in the dorsal and medial regions of the telencephalon by embryonic day 13.5. In adult cerebellum, only astrocytes are immunoreactive for GFAP or Cre recombinase. This mutant mouse strain represents an effective tool for generating central nervous system specific-targeted mutants.View cre expression characterization.
Development
A transgenic construct containing a 2.2Kb 5' flanking region of the human GFAP gene, cre coding sequence, the SV40 nuclear localization signal, and a portion of the mouse protamine (Prm1) gene which supplies intronic sequence and a polyadenylation site, was injected into fertilized FVB/N mouse eggs.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 001800 FVB/NJ | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of GFAP
View Strains carrying other alleles of GFAP (20 strains)
Additional Web Information
Introduction to Cre-lox technology
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
cre relatedNeurobiology Research
Cre-lox System
Cre Recombinase expression in neural tissue
Research Tools
Cre-lox System
Cre Recombinase Expression
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Neurobiology Research
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Tg(GFAP-cre)25Mes | ||
|---|---|---|---|
| Allele Name | transgene insertion 25, Albee Messing | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | GFAP-Cre; GFAP-Cre-m; Gfa2-Cre; Tg95.2; TgN(GFAPcre)25Mes; TgN25Mes; hGFAP-cre; hGFAP::Cre; hGFAPcre; | ||
| Mutation Made By | Dr. Albee Messing, University of Wisconsin-Madison | ||
| Strain of Origin | FVB/N | ||
| Site of Expression | primarily in the central nervous system, affecting astrocytes, oligodendroglia, ependyma and some neurons; also periportal cells of the liver | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | GFAP, glial fibrillary acidic protein, human | ||
| Gene Symbol and Name | Tg(GFAP-cre)25Mes, transgene insertion 25, Albee Messing | ||
| Chromosome | UN | ||
| Gene Common Name(s) | GFAP-Cre; GFAP-Cre-m; Tg95.2; TgN(GFAPcre)25Mes; TgN25Mes; hGFAP-cre; hGFAP::Cre; | ||
| Driver Note | GFAP | ||
| General Note | Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. Mice that are homozygous for the transgene are not viable. | ||
| Molecular Note | This transgene expresses Cre recombinase under the control of a human glial fibrillary acidic protein (GFAP) promoter. Cre-mediated recombination occurs primarily in the central nervous system, affecting astrocytes, oligodendroglia, ependyma and some neurons. Expression activity is also present in periportal cells of the liver. Developmental onset of transgene expression occurs in the dorsal and medial regions of the telencephalon by embryonic day 13.5. In adult cerebellum, only astrocytes are immunoreactive for GFAP or Cre recombinase. [MGI Ref ID J:72509] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Tg(GFAP-cre)25Mes, Melt Curve Analysis
Tg(GFAP-cre)25Mes, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Zhuo L; Theis M; Alvarez-Maya I; Brenner M; Willecke K; Messing A. 2001. hGFAP-cre transgenic mice for manipulation of glial and neuronal function in vivo. Genesis 31(2):85-94. [PubMed: 11668683] [MGI Ref ID J:72509]
Additional References
Moore SA; Saito F; Chen J; Michele DE; Henry MD; Messing A; Cohn RD; Ross-Barta SE; Westra S; Williamson RA; Hoshi T; Campbell KP. 2002. Deletion of brain dystroglycan recapitulates aspects of congenital muscular dystrophy. Nature 418(6896):422-5. [PubMed: 12140559] [MGI Ref ID J:86901]
Tg(GFAP-cre)25Mes relatedAngo F; Wu C; Van der Want JJ; Wu P; Schachner M; Huang ZJ. 2008. Bergmann glia and the recognition molecule CHL1 organize GABAergic axons and direct innervation of Purkinje cell dendrites. PLoS Biol 6(4):e103. [PubMed: 18447583] [MGI Ref ID J:136656]
Anthony TE; Heintz N. 2008. Genetic lineage tracing defines distinct neurogenic and gliogenic stages of ventral telencephalic radial glial development. Neural Dev 3:30. [PubMed: 18986511] [MGI Ref ID J:160736]
Anton ES; Ghashghaei HT; Weber JL; McCann C; Fischer TM; Cheung ID; Gassmann M; Messing A; Klein R; Schwab MH; Lloyd KC; Lai C. 2004. Receptor tyrosine kinase ErbB4 modulates neuroblast migration and placement in the adult forebrain. Nat Neurosci 7(12):1319-28. [PubMed: 15543145] [MGI Ref ID J:95821]
Barbosa AC; Kim MS; Ertunc M; Adachi M; Nelson ED; McAnally J; Richardson JA; Kavalali ET; Monteggia LM; Bassel-Duby R; Olson EN. 2008. MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function. Proc Natl Acad Sci U S A 105(27):9391-6. [PubMed: 18599438] [MGI Ref ID J:138188]
Barros CS; Calabrese B; Chamero P; Roberts AJ; Korzus E; Lloyd K; Stowers L; Mayford M; Halpain S; Muller U. 2009. Impaired maturation of dendritic spines without disorganization of cortical cell layers in mice lacking NRG1/ErbB signaling in the central nervous system. Proc Natl Acad Sci U S A 106(11):4507-12. [PubMed: 19240213] [MGI Ref ID J:146779]
Bashir T; Cloninger C; Artinian N; Anderson L; Bernath A; Holmes B; Benavides-Serrato A; Sabha N; Nishimura RN; Guha A; Gera J. 2012. Conditional astroglial Rictor overexpression induces malignant glioma in mice. PLoS One 7(10):e47741. [PubMed: 23077666] [MGI Ref ID J:192206]
Benadiba C; Magnani D; Niquille M; Morle L; Valloton D; Nawabi H; Ait-Lounis A; Otsmane B; Reith W; Theil T; Hornung JP; Lebrand C; Durand B. 2012. The ciliogenic transcription factor RFX3 regulates early midline distribution of guidepost neurons required for corpus callosum development. PLoS Genet 8(3):e1002606. [PubMed: 22479201] [MGI Ref ID J:183848]
Cai J; Chen Y; Cai WH; Hurlock EC; Wu H; Kernie SG; Parada LF; Lu QR. 2007. A crucial role for Olig2 in white matter astrocyte development. Development 134(10):1887-99. [PubMed: 17428828] [MGI Ref ID J:121422]
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Catchpole T; Henkemeyer M. 2011. EphB2 tyrosine kinase-dependent forward signaling in migration of neuronal progenitors that populate and form a distinct region of the dentate niche. J Neurosci 31(32):11472-83. [PubMed: 21832177] [MGI Ref ID J:175976]
Chen J; Li Y; Yu TS; McKay RM; Burns DK; Kernie SG; Parada LF. 2012. A restricted cell population propagates glioblastoma growth after chemotherapy. Nature 488(7412):522-6. [PubMed: 22854781] [MGI Ref ID J:186769]
Chen MJ; Kress B; Han X; Moll K; Peng W; Ji RR; Nedergaard M. 2012. Astrocytic CX43 hemichannels and gap junctions play a crucial role in development of chronic neuropathic pain following spinal cord injury. Glia 60(11):1660-70. [PubMed: 22951907] [MGI Ref ID J:187682]
Chen Y; Miles DK; Hoang T; Shi J; Hurlock E; Kernie SG; Lu QR. 2008. The basic helix-loop-helix transcription factor olig2 is critical for reactive astrocyte proliferation after cortical injury. J Neurosci 28(43):10983-9. [PubMed: 18945906] [MGI Ref ID J:143796]
Chenaux G; Henkemeyer M. 2011. Forward signaling by EphB1/EphB2 interacting with ephrin-B ligands at the optic chiasm is required to form the ipsilateral projection. Eur J Neurosci 34(10):1620-33. [PubMed: 22103419] [MGI Ref ID J:184158]
Chizhikov VV; Davenport J; Zhang Q; Shih EK; Cabello OA; Fuchs JL; Yoder BK; Millen KJ. 2007. Cilia proteins control cerebellar morphogenesis by promoting expansion of the granule progenitor pool. J Neurosci 27(36):9780-9. [PubMed: 17804638] [MGI Ref ID J:145113]
Choi JW; Gardell SE; Herr DR; Rivera R; Lee CW; Noguchi K; Teo ST; Yung YC; Lu M; Kennedy G; Chun J. 2011. FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation. Proc Natl Acad Sci U S A 108(2):751-6. [PubMed: 21177428] [MGI Ref ID J:168824]
Choi YH; Park CH; Kim W; Ling H; Kang A; Chang MW; Im SK; Jeong HW; Kong YY; Kim KT. 2010. Vaccinia-related kinase 1 is required for the maintenance of undifferentiated spermatogonia in mouse male germ cells. PLoS One 5(12):e15254. [PubMed: 21179456] [MGI Ref ID J:168994]
Colombo E; Cordiglieri C; Melli G; Newcombe J; Krumbholz M; Parada LF; Medico E; Hohlfeld R; Meinl E; Farina C. 2012. Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration. J Exp Med 209(3):521-35. [PubMed: 22393127] [MGI Ref ID J:182678]
D'Arca D; Zhao X; Xu W; Ramirez-Martinez NC; Iavarone A; Lasorella A. 2010. Huwe1 ubiquitin ligase is essential to synchronize neuronal and glial differentiation in the developing cerebellum. Proc Natl Acad Sci U S A 107(13):5875-80. [PubMed: 20231446] [MGI Ref ID J:158649]
Degen J; Dublin P; Zhang J; Dobrowolski R; Jokwitz M; Karram K; Trotter J; Jabs R; Willecke K; Steinhauser C; Theis M. 2012. Dual reporter approaches for identification of Cre efficacy and astrocyte heterogeneity. FASEB J 26(11):4576-83. [PubMed: 22859373] [MGI Ref ID J:193352]
Eckardt D; Theis M; Doring B; Speidel D; Willecke K; Ott T. 2004. Spontaneous ectopic recombination in cell-type-specific Cre mice removes loxP-flanked marker cassettes in vivo. Genesis 38(4):159-65. [PubMed: 15083516] [MGI Ref ID J:90577]
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Ma S; Kwon HJ; Huang Z. 2012. Ric-8a, a guanine nucleotide exchange factor for heterotrimeric G proteins, regulates bergmann glia-basement membrane adhesion during cerebellar foliation. J Neurosci 32(43):14979-93. [PubMed: 23100420] [MGI Ref ID J:191222]
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Monteggia LM; Luikart B; Barrot M; Theobold D; Malkovska I; Nef S; Parada LF; Nestler EJ. 2007. Brain-derived neurotrophic factor conditional knockouts show gender differences in depression-related behaviors. Biol Psychiatry 61(2):187-97. [PubMed: 16697351] [MGI Ref ID J:129526]
Montgomery RL; Hsieh J; Barbosa AC; Richardson JA; Olson EN. 2009. Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development. Proc Natl Acad Sci U S A 106(19):7876-81. [PubMed: 19380719] [MGI Ref ID J:148408]
Moon BC; Hernandez-Ono A; Stiles B; Wu H; Ginsberg HN. 2012. Apolipoprotein B secretion is regulated by hepatic triglyceride, and not insulin, in a model of increased hepatic insulin signaling. Arterioscler Thromb Vasc Biol 32(2):236-46. [PubMed: 22155452] [MGI Ref ID J:195966]
Moore SA; Saito F; Chen J; Michele DE; Henry MD; Messing A; Cohn RD; Ross-Barta SE; Westra S; Williamson RA; Hoshi T; Campbell KP. 2002. Deletion of brain dystroglycan recapitulates aspects of congenital muscular dystrophy. Nature 418(6896):422-5. [PubMed: 12140559] [MGI Ref ID J:86901]
Muller Smith K; Fagel DM; Stevens HE; Rabenstein RL; Maragnoli ME; Ohkubo Y; Picciotto MR; Schwartz ML; Vaccarino FM. 2008. Deficiency in inhibitory cortical interneurons associates with hyperactivity in fibroblast growth factor receptor 1 mutant mice. Biol Psychiatry 63(10):953-62. [PubMed: 17988653] [MGI Ref ID J:139827]
Muller Smith K; Williamson TL; Schwartz ML; Vaccarino FM. 2012. Impaired motor coordination and disrupted cerebellar architecture in Fgfr1 and Fgfr2 double knockout mice. Brain Res 1460:12-24. [PubMed: 22578469] [MGI Ref ID J:186443]
Nakase T; Fushiki S; Sohl G; Theis M; Willecke K; Naus CC. 2003. Neuroprotective role of astrocytic gap junctions in ischemic stroke. Cell Commun Adhes 10(4-6):413-7. [PubMed: 14681050] [MGI Ref ID J:103075]
Nakase T; Sohl G; Theis M; Willecke K; Naus CC. 2004. Increased apoptosis and inflammation after focal brain ischemia in mice lacking connexin43 in astrocytes. Am J Pathol 164(6):2067-75. [PubMed: 15161641] [MGI Ref ID J:91068]
Namekata K; Harada C; Taya C; Guo X; Kimura H; Parada LF; Harada T. 2010. Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex. Proc Natl Acad Sci U S A 107(16):7586-91. [PubMed: 20368433] [MGI Ref ID J:159284]
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Poschl J; Grammel D; Dorostkar MM; Kretzschmar HA; Schuller U. 2013. Constitutive activation of beta-catenin in neural progenitors results in disrupted proliferation and migration of neurons within the central nervous system. Dev Biol 374(2):319-32. [PubMed: 23237957] [MGI Ref ID J:193531]
Requardt RP; Kaczmarczyk L; Dublin P; Wallraff-Beck A; Mikeska T; Degen J; Waha A; Steinhauser C; Willecke K; Theis M. 2009. Quality control of astrocyte-directed Cre transgenic mice: the benefits of a direct link between loss of gene expression and reporter activation. Glia 57(6):680-92. [PubMed: 18942753] [MGI Ref ID J:156217]
Robel S; Mori T; Zoubaa S; Schlegel J; Sirko S; Faissner A; Goebbels S; Dimou L; Gotz M. 2009. Conditional deletion of beta1-integrin in astroglia causes partial reactive gliosis. Glia 57(15):1630-47. [PubMed: 19373938] [MGI Ref ID J:156199]
Rouach N; Koulakoff A; Abudara V; Willecke K; Giaume C. 2008. Astroglial metabolic networks sustain hippocampal synaptic transmission. Science 322(5907):1551-5. [PubMed: 19056987] [MGI Ref ID J:142034]
Samuels IS; Karlo JC; Faruzzi AN; Pickering K; Herrup K; Sweatt JD; Saitta SC; Landreth GE. 2008. Deletion of ERK2 mitogen-activated protein kinase identifies its key roles in cortical neurogenesis and cognitive function. J Neurosci 28(27):6983-95. [PubMed: 18596172] [MGI Ref ID J:137882]
Satz JS; Ostendorf AP; Hou S; Turner A; Kusano H; Lee JC; Turk R; Nguyen H; Ross-Barta SE; Westra S; Hoshi T; Moore SA; Campbell KP. 2010. Distinct functions of glial and neuronal dystroglycan in the developing and adult mouse brain. J Neurosci 30(43):14560-72. [PubMed: 20980614] [MGI Ref ID J:166208]
Satz JS; Philp AR; Nguyen H; Kusano H; Lee J; Turk R; Riker MJ; Hernandez J; Weiss RM; Anderson MG; Mullins RF; Moore SA; Stone EM; Campbell KP. 2009. Visual impairment in the absence of dystroglycan. J Neurosci 29(42):13136-46. [PubMed: 19846701] [MGI Ref ID J:158199]
Schuller U; Heine VM; Mao J; Kho AT; Dillon AK; Han YG; Huillard E; Sun T; Ligon AH; Qian Y; Ma Q; Alvarez-Buylla A; McMahon AP; Rowitch DH; Ligon KL. 2008. Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. Cancer Cell 14(2):123-34. [PubMed: 18691547] [MGI Ref ID J:139574]
Sherrod M; Davis DR; Zhou X; Cassell MD; Sigmund CD. 2005. Glial-specific ablation of angiotensinogen lowers arterial pressure in renin and angiotensinogen transgenic mice. Am J Physiol Regul Integr Comp Physiol 289(6):R1763-9. [PubMed: 16109805] [MGI Ref ID J:130651]
Silvis MR; Kreger BT; Lien WH; Klezovitch O; Rudakova GM; Camargo FD; Lantz DM; Seykora JT; Vasioukhin V. 2011. alpha-catenin is a tumor suppressor that controls cell accumulation by regulating the localization and activity of the transcriptional coactivator Yap1. Sci Signal 4(174):ra33. [PubMed: 21610251] [MGI Ref ID J:185995]
Smith KM; Ohkubo Y; Maragnoli ME; Rasin MR; Schwartz ML; Sestan N; Vaccarino FM. 2006. Midline radial glia translocation and corpus callosum formation require FGF signaling. Nat Neurosci 9(6):787-97. [PubMed: 16715082] [MGI Ref ID J:110263]
Soda Y; Marumoto T; Friedmann-Morvinski D; Soda M; Liu F; Michiue H; Pastorino S; Yang M; Hoffman RM; Kesari S; Verma IM. 2011. From the Cover: Feature Article: Transdifferentiation of glioblastoma cells into vascular endothelial cells. Proc Natl Acad Sci U S A 108(11):4274-80. [PubMed: 21262804] [MGI Ref ID J:170761]
Spassky N; Han YG; Aguilar A; Strehl L; Besse L; Laclef C; Ros MR; Garcia-Verdugo JM; Alvarez-Buylla A. 2008. Primary cilia are required for cerebellar development and Shh-dependent expansion of progenitor pool. Dev Biol 317(1):246-59. [PubMed: 18353302] [MGI Ref ID J:136079]
Stalnaker SH; Aoki K; Lim JM; Porterfield M; Liu M; Satz JS; Buskirk S; Xiong Y; Zhang P; Campbell KP; Hu H; Live D; Tiemeyer M; Wells L. 2011. Glycomic analyses of mouse models of congenital muscular dystrophy. J Biol Chem 286(24):21180-90. [PubMed: 21460210] [MGI Ref ID J:173659]
Stevens HE; Smith KM; Maragnoli ME; Fagel D; Borok E; Shanabrough M; Horvath TL; Vaccarino FM. 2010. Fgfr2 is required for the development of the medial prefrontal cortex and its connections with limbic circuits. J Neurosci 30(16):5590-602. [PubMed: 20410112] [MGI Ref ID J:159839]
Tanaka M; Yamaguchi K; Tatsukawa T; Theis M; Willecke K; Itohara S. 2008. Connexin43 and bergmann glial gap junctions in cerebellar function. Front Neurosci 2(2):225-33. [PubMed: 19225596] [MGI Ref ID J:159159]
Theis M; Jauch R; Zhuo L; Speidel D; Wallraff A; Doring B; Frisch C; Sohl G; Teubner B; Euwens C; Huston J; Steinhauser C; Messing A; Heinemann U; Willecke K. 2003. Accelerated hippocampal spreading depression and enhanced locomotory activity in mice with astrocyte-directed inactivation of connexin43. J Neurosci 23(3):766-76. [PubMed: 12574405] [MGI Ref ID J:81921]
Theis M; Speidel D; Willecke K. 2004. Astrocyte cultures from conditional connexin43-deficient mice. Glia 46(2):130-41. [PubMed: 15042581] [MGI Ref ID J:156062]
Tsai PT; Ohab JJ; Kertesz N; Groszer M; Matter C; Gao J; Liu X; Wu H; Carmichael ST. 2006. A critical role of erythropoietin receptor in neurogenesis and post-stroke recovery. J Neurosci 26(4):1269-74. [PubMed: 16436614] [MGI Ref ID J:104816]
Tuoc TC; Radyushkin K; Tonchev AB; Pinon MC; Ashery-Padan R; Molnar Z; Davidoff MS; Stoykova A. 2009. Selective cortical layering abnormalities and behavioral deficits in cortex-specific Pax6 knock-out mice. J Neurosci 29(26):8335-49. [PubMed: 19571125] [MGI Ref ID J:150808]
Wallraff A; Kohling R; Heinemann U; Theis M; Willecke K; Steinhauser C. 2006. The impact of astrocytic gap junctional coupling on potassium buffering in the hippocampus. J Neurosci 26(20):5438-47. [PubMed: 16707796] [MGI Ref ID J:108703]
Wallraff A; Odermatt B; Willecke K; Steinhauser C. 2004. Distinct types of astroglial cells in the hippocampus differ in gap junction coupling. Glia 48(1):36-43. [PubMed: 15326613] [MGI Ref ID J:156058]
Wang Y; Yang J; Zheng H; Tomasek GJ; Zhang P; McKeever PE; Lee EY; Zhu Y. 2009. Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model. Cancer Cell 15(6):514-26. [PubMed: 19477430] [MGI Ref ID J:149662]
Way SW; McKenna J rd; Mietzsch U; Reith RM; Wu HC; Gambello MJ. 2009. Loss of Tsc2 in radial glia models the brain pathology of tuberous sclerosis complex in the mouse. Hum Mol Genet 18(7):1252-65. [PubMed: 19150975] [MGI Ref ID J:146159]
Way SW; Rozas NS; Wu HC; McKenna J 3rd; Reith RM; Hashmi SS; Dash PK; Gambello MJ. 2012. The differential effects of prenatal and/or postnatal rapamycin on neurodevelopmental defects and cognition in a neuroglial mouse model of tuberous sclerosis complex. Hum Mol Genet 21(14):3226-36. [PubMed: 22532572] [MGI Ref ID J:185369]
Xu D; Borges GR; Davis DR; Agassandian K; Sequeira Lopez ML; Gomez RA; Cassell MD; Grobe JL; Sigmund CD. 2010. Neuron- or Glial-Specific Ablation of Secreted Renin Does Not Affect Renal Renin, Baseline Arterial Pressure or Metabolism. Physiol Genomics :. [PubMed: 21189370] [MGI Ref ID J:168753]
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Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX12
Colony Maintenance
Breeding & Husbandry The strain is maintained as a hemizygote on the FVB/N background. Mating System Noncarrier x Hemizygote (Female x Male) 25-OCT-08 Diet Information LabDiet® 5K52/5K67
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $232.00 Female or Male Hemizygous for Tg(GFAP-cre)25Mes
Price per Pair (US dollars $) Pair Genotype $302.00 Hemizygous for Tg(GFAP-cre)25Mes x Noncarrier $302.00 Noncarrier x Hemizygous for Tg(GFAP-cre)25Mes Standard Supply
Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.
| Pricing for International shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $301.60 Female or Male Hemizygous for Tg(GFAP-cre)25Mes
Price per Pair (US dollars $) Pair Genotype $392.60 Hemizygous for Tg(GFAP-cre)25Mes x Noncarrier $392.60 Noncarrier x Hemizygous for Tg(GFAP-cre)25Mes Standard Supply
Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.
|
|
|
Standard Supply
Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 001800 FVB/NJ | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
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