Strain Name:

B6.129S1-Il11ra1tm1Wehi/J

Stock Number:

004621

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Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names B6.129S1-Il11ra1tm1Wehi    (Changed: 15-DEC-04 )
Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
 
Donating Investigator John W. Adamson,   Blood Research Institute

Description
Mice homozygous for the targeted allele are viable, normal in size and do not display any gross physical or behavioral abnormalities. No transcripts are detected in kidney, testis or bone marrow. Bone marrow cells derived from homozygous mice fail to display the synergistic growth reaction usually observed in response to the combined treatment with interleukin-11 and interleukin-3 or stem cell factor in hematopoietic assays. Homozygous females are infertile due to defective decidualization the process necessary for successful implantation whereby the uterine stroma transforms into a specialized tissue known as decidua. Fertilty of homozygous males is normal. This mutant mouse strain may be useful in studies related to hematopoiesis and female reproduction.

Development
A targeting vector containing neomycin phosphotransferase and thymidine kinase cassettes was used to disrupt parts of exons 8 and 13 and all of exons 7-12 of the targeted gene. The construct was electroporated into 129S1/Sv-p+ Tyr+ KitlSl-J-derived W9.5 embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6 blastocysts.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Craniosynostosis and Dental Anomalies; CRSDA   (IL11RA)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Il11ra1tm1Wehi/Il11ra1tm1Wehi

        involves: 129S1/Sv * C57BL/6
  • mortality/aging
  • *normal* mortality/aging
    • homozygotes are viable and appear phenotypically normal both at birth and during adulthood (at least up to 8 months of age)   (MGI Ref ID J:42921)
  • reproductive system phenotype
  • female infertility   (MGI Ref ID J:42921)
  • hematopoietic system phenotype
  • *normal* hematopoietic system phenotype
    • adult homozygotes exhibit normal steady-state hematopoiesis, with normal numbers of peripheral blood white blood cells, hematocrit, and platelets   (MGI Ref ID J:42921)
    • bone marrow and spleen contain normal numbers of cells of all hematopoietic lineages, including megakaryocytes   (MGI Ref ID J:42921)
    • in addition, homozygotes show normal kinetics of hematopoietic recovery in response to cytotoxic stress or phenylhydrazine-induced acute hemolysis   (MGI Ref ID J:42921)
  • immune system phenotype
  • *normal* immune system phenotype
    • adult homozygotes show normal levels of Ig isotypes as well as a normal antibody response to a T-cell-dependent antigen (NP)   (MGI Ref ID J:42921)
    • adult homozygotes do NOT develop degenerative joint disease   (MGI Ref ID J:79073)
  • digestive/alimentary phenotype
  • *normal* digestive/alimentary phenotype
    • adult homozygotes do NOT develop spontaneous gastric hyperplasia or gastric adenomas   (MGI Ref ID J:79073)

Il11ra1tm1Wehi/Il11ra1tm1Wehi

        either: (involves: 129S1/Sv) or (involves: 129S1/Sv * C57BL/6)
  • mortality/aging
  • complete embryonic lethality during organogenesis
    • intercrosses of heterozygotes produce viable homozygous offspring at the expected Mendelian ratios   (MGI Ref ID J:46263)
    • however, embryos developing in homozygous mutant mothers appear necrotic at >7.5 dpc, with rare instances (<1%) of intact embryos detected at 9.5 dpc, and no live embryos found after 10.5 dpc   (MGI Ref ID J:46263)
    • notably, 2.5 dpc mutant embryos survive normally when transferred in foster uteri, whereas wild-type embryos fail to do so in uteri of mutant mice   (MGI Ref ID J:46263)
  • reproductive system phenotype
  • *normal* reproductive system phenotype
    • virgin female homozygotes display normal estrous cyclicity and mating behavior, as well as histologically normal ovaries, oviducts, vagina and uterus   (MGI Ref ID J:46263)
    • abnormal decidua basalis morphology
      • the decidua basalis is entirely absent, being replaced by multiple layers of trophoblast giant cells   (MGI Ref ID J:46263)
    • abnormal decidua capsularis morphology
      • in a few cases, the decidua capsularis is present but significantly thinner   (MGI Ref ID J:46263)
    • abnormal decidualization
      • at 4.5 dpc, uteri of pregnant homozygotes display a reduced secondary decidual response to the implanting blastocyst   (MGI Ref ID J:46263)
      • at 5.5-7.5 dpc, mutant deciduae are significantly smaller, displaying hemorrhage in the uterine lumen, disruption of the antimesometrium, and overgrowth of giant trophoblast cells in the mesometrial portion of the deciduum   (MGI Ref ID J:46263)
      • notably, pseudopregnant homozygotes show reduced deciduoma formation in response to an artificial (oil) stimulus, albeit with partial preservation of mesometrial decidual tissue   (MGI Ref ID J:46263)
    • impaired embryo implantation
      • at 4.5-7.5 dpc, homozygotes display a normal number of implantation sites relative to wild-type mice   (MGI Ref ID J:46263)
      • however, mutants show reduced capillary permeability and blood flow in the uterine vascular bed at the site of blastocyst apposition   (MGI Ref ID J:46263)
  • embryogenesis phenotype
  • abnormal decidua basalis morphology
    • the decidua basalis is entirely absent, being replaced by multiple layers of trophoblast giant cells   (MGI Ref ID J:46263)
  • abnormal decidua capsularis morphology
    • in a few cases, the decidua capsularis is present but significantly thinner   (MGI Ref ID J:46263)
  • abnormal placenta development
    • in most cases, embryos surviving in 9.5 dpc mutant uteri contain fibrinoid material and inflammatory cells in the space normally occupied by the placenta   (MGI Ref ID J:46263)
    • in a few cases, embryos surviving in 9.5 dpc mutant uteri display fetal components of the chorioallantoic placenta; however, the decidua basalis is entirely absent, being replaced by multiple layers of trophoblast giant cells, while the decidua capsularis is present but significantly thinner   (MGI Ref ID J:46263)
    • abnormal decidualization
      • at 4.5 dpc, uteri of pregnant homozygotes display a reduced secondary decidual response to the implanting blastocyst   (MGI Ref ID J:46263)
      • at 5.5-7.5 dpc, mutant deciduae are significantly smaller, displaying hemorrhage in the uterine lumen, disruption of the antimesometrium, and overgrowth of giant trophoblast cells in the mesometrial portion of the deciduum   (MGI Ref ID J:46263)
      • notably, pseudopregnant homozygotes show reduced deciduoma formation in response to an artificial (oil) stimulus, albeit with partial preservation of mesometrial decidual tissue   (MGI Ref ID J:46263)
  • increased trophoblast giant cell number
    • pregnant homozygotes exhibit a significantly increased number of secondary trophoblast giant cells in the mutant decidua   (MGI Ref ID J:46263)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Il11ra1tm1Wehi related

Reproductive Biology Research
Fertility Defects
      females only

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Il11ra1tm1Wehi
Allele Name targeted mutation 1, Walter and Eliza Hall Institute of Medical Research
Allele Type Targeted (Null/Knockout)
Common Name(s) IL-11Ralpha1-; IL11Ra -;
Mutation Made By Laura Savatski,   Blood Research Institute
Strain of Origin129S1/Sv-Oca2<+> Tyr<+> Kitl<+>
ES Cell Line NameW9.5/W95
ES Cell Line Strain129S1/Sv-Oca2<+> Tyr<+> Kitl<+>
Gene Symbol and Name Il11ra1, interleukin 11 receptor, alpha chain 1
Chromosome 4
Gene Common Name(s) AI314697; CRSDA; Il-11ra; Il-11ra-alpha; Il11ra; NR1; expressed sequence AI314697; interleukin 11 receptor, alpha chain;
Molecular Note A neomycin selection cassette replaced a genomic fragment containing exons 9-12 and part of 8 and 13. Northern blot analysis on RNA derived from kidney and testis of homozygous mice demonstrated that no detectable transcript was produced from this allele. [MGI Ref ID J:42921]

Genotyping

Genotyping Information

Genotyping Protocols

Il11ra1tm1Wehi, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Il11ra1tm1Wehi related

Bollrath J; Phesse TJ; von Burstin VA; Putoczki T; Bennecke M; Bateman T; Nebelsiek T; Lundgren-May T; Canli O; Schwitalla S; Matthews V; Schmid RM; Kirchner T; Arkan MC; Ernst M; Greten FR. 2009. gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis. Cancer Cell 15(2):91-102. [PubMed: 19185844]  [MGI Ref ID J:144814]

Chen Q; Rabach L; Noble P; Zheng T; Lee CG; Homer RJ; Elias JA. 2005. IL-11 receptor alpha in the pathogenesis of IL-13-induced inflammation and remodeling. J Immunol 174(4):2305-13. [PubMed: 15699166]  [MGI Ref ID J:96565]

Ernst M; Najdovska M; Grail D; Lundgren-May T; Buchert M; Tye H; Matthews VB; Armes J; Bhathal PS; Hughes NR; Marcusson EG; Karras JG; Na S; Sedgwick JD; Hertzog PJ; Jenkins BJ. 2008. STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice. J Clin Invest 118(5):1727-38. [PubMed: 18431520]  [MGI Ref ID J:135184]

Gu D; Fan Q; Zhang X; Xie J. 2012. A role for transcription factor STAT3 signaling in oncogene smoothened-driven carcinogenesis. J Biol Chem 287(45):38356-66. [PubMed: 22992748]  [MGI Ref ID J:192468]

Gurfein BT; Zhang Y; Lopez CB; Argaw AT; Zameer A; Moran TM; John GR. 2009. IL-11 regulates autoimmune demyelination. J Immunol 183(7):4229-40. [PubMed: 19734214]  [MGI Ref ID J:152791]

Howlett M; Giraud AS; Lescesen H; Jackson CB; Kalantzis A; Van Driel IR; Robb L; Van der Hoek M; Ernst M; Minamoto T; Boussioutas A; Oshima H; Oshima M; Judd LM. 2009. The interleukin-6 family cytokine interleukin-11 regulates homeostatic epithelial cell turnover and promotes gastric tumor development. Gastroenterology 136(3):967-77. [PubMed: 19121317]  [MGI Ref ID J:146915]

Judd LM; Ulaganathan M; Howlett M; Giraud AS. 2009. Cytokine signalling by gp130 regulates gastric mucosal healing after ulceration and, indirectly, antral tumour progression. J Pathol 217(4):552-62. [PubMed: 19097069]  [MGI Ref ID J:145736]

Lee CG; Hartl D; Matsuura H; Dunlop FM; Scotney PD; Fabri LJ; Nash AD; Chen NY; Tang CY; Chen Q; Homer RJ; Baca M; Elias JA. 2008. Endogenous IL-11 signaling is essential in Th2- and IL-13-induced inflammation and mucus production. Am J Respir Cell Mol Biol 39(6):739-46. [PubMed: 18617680]  [MGI Ref ID J:155999]

Li F; Devi YS; Bao L; Mao J; Gibori G. 2008. Involvement of cyclin D3, CDKN1A (p21), and BIRC5 (Survivin) in interleukin 11 stimulation of decidualization in mice. Biol Reprod 78(1):127-33. [PubMed: 17881769]  [MGI Ref ID J:130792]

Menkhorst E; Salamonsen L; Robb L; Dimitriadis E. 2009. IL11 antagonist inhibits uterine stromal differentiation, causing pregnancy failure in mice. Biol Reprod 80(5):920-7. [PubMed: 19144959]  [MGI Ref ID J:149635]

Nandurkar HH; Robb L; Tarlinton D; Barnett L; Kontgen F; Begley CG. 1997. Adult mice with targeted mutation of the interleukin-11 receptor (IL11Ra) display normal hematopoiesis. Blood 90(6):2148-59. [PubMed: 9310465]  [MGI Ref ID J:42921]

Nieminen P; Morgan NV; Fenwick AL; Parmanen S; Veistinen L; Mikkola ML; van der Spek PJ; Giraud A; Judd L; Arte S; Brueton LA; Wall SA; Mathijssen IM; Maher ER; Wilkie AO; Kreiborg S; Thesleff I. 2011. Inactivation of IL11 signaling causes craniosynostosis, delayed tooth eruption, and supernumerary teeth. Am J Hum Genet 89(1):67-81. [PubMed: 21741611]  [MGI Ref ID J:186799]

Putoczki TL; Thiem S; Loving A; Busuttil RA; Wilson NJ; Ziegler PK; Nguyen PM; Preaudet A; Farid R; Edwards KM; Boglev Y; Luwor RB; Jarnicki A; Horst D; Boussioutas A; Heath JK; Sieber OM; Pleines I; Kile BT; Nash A; Greten FR; McKenzie BS; Ernst M. 2013. Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically. Cancer Cell 24(2):257-71. [PubMed: 23948300]  [MGI Ref ID J:202609]

Robb L; Li R; Hartley L; Nandurkar HH; Koentgen F; Begley CG. 1998. Infertility in female mice lacking the receptor for interleukin 11 is due to a defective uterine response to implantation. Nat Med 4(3):303-8. [PubMed: 9500603]  [MGI Ref ID J:46263]

Ruwanpura SM; McLeod L; Miller A; Jones J; Bozinovski S; Vlahos R; Ernst M; Armes J; Bardin PG; Anderson GP; Jenkins BJ. 2011. Interleukin-6 promotes pulmonary emphysema associated with apoptosis in mice. Am J Respir Cell Mol Biol 45(4):720-30. [PubMed: 21297079]  [MGI Ref ID J:190215]

Sims NA. 2009. gp130 signaling in bone cell biology: multiple roles revealed by analysis of genetically altered mice. Mol Cell Endocrinol 310(1-2):30-9. [PubMed: 18805458]  [MGI Ref ID J:155075]

Sims NA; Jenkins BJ; Nakamura A; Quinn JM; Li R; Gillespie MT; Ernst M; Robb L; Martin TJ. 2005. Interleukin-11 receptor signaling is required for normal bone remodeling. J Bone Miner Res 20(7):1093-102. [PubMed: 15940362]  [MGI Ref ID J:111457]

Tebbutt NC; Giraud AS; Inglese M; Jenkins B; Waring P; Clay FJ; Malki S; Alderman BM; Grail D; Hollande F; Heath JK; Ernst M. 2002. Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice. Nat Med 8(10):1089-97. [PubMed: 12219085]  [MGI Ref ID J:79073]

Thiem S; Pierce TP; Palmieri M; Putoczki TL; Buchert M; Preaudet A; Farid RO; Love C; Catimel B; Lei Z; Rozen S; Gopalakrishnan V; Schaper F; Hallek M; Boussioutas A; Tan P; Jarnicki A; Ernst M. 2013. mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice. J Clin Invest :. [PubMed: 23321674]  [MGI Ref ID J:194490]

Zhang J; Zhang Y; Dutta DJ; Argaw AT; Bonnamain V; Seto J; Braun DA; Zameer A; Hayot F; Lopez CB; Raine CS; John GR. 2011. Proapoptotic and antiapoptotic actions of Stat1 versus Stat3 underlie neuroprotective and immunoregulatory functions of IL-11. J Immunol 187(3):1129-41. [PubMed: 21709156]  [MGI Ref ID J:179183]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryChimeric animals were crossed to C57BL/6 mice by the originating investigator, Dr. Glenn Begley. Subsequently, the mice were backcrossed to C57BL/6 for twelve generations by the Blood Research Institute (Milwaukee) before arriving at The Jackson Laboratory. When maintained in a live colony, these mice were maintained by crossing heterozygous males to wildtype C57BL/6 females and reciprocal. Please note that homozygous females are infertile (see phenotype).

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2525.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3283.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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