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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Type Mutant Stock; Transgenic; Additional information on Genetically Engineered Mutant Mice. Mating System +/+ sibling x Hemizygote (Female x Male) Species laboratory mouse Generation N1F10 (05-DEC-07) Donating Investigator Elaine Fuchs, The Rockefeller University Important Note
This strain may be homozygous for Gnat2cpfl3, cone photoreceptor function loss 3, which affects bright light (photopic) vision.Description
These TOPGAL transgenic mice are a reporter strain that express Beta-galactosidase in the presence of the lymphoid enhancer binding factor 1/transcription factor 3 (LEF/TCF) mediated signaling pathway and activated Beta-catenin. The transgene contains the lacZ gene under the control of a regulatory sequence consisting of three consensus LEF/TCF-binding motifs upstream of a minimal c-fos promoter. Transgenic mice display TOPGAL activity (Beta-galactosidase activity) during early embryonic development in a subset of pluripotent embryonic basal cells of the epithelium and dermis of developing hair follicles, but not during the next stage of hair follicle development; formation of hair germs. TOPGAL transgene activity reappears in hair follicles at E16.5 and TOPGAL expression is strongly upregulated in the postnatal hair shaft precursor cells in both whisker and body hair anagen follicles (active periods of hair growth). TOPGAL expression ceases during catagen (regression and shortening) and telogen (rest) periods of the postnatal hair growth cycle. Mice homozygous for the transgenic insert are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. This strain represents an effective tool for generating mutants that would be useful in studies of the Wnt signaling pathway.Development
A transgenic construct containing the lacZ gene under the control of a promoter consisting of three consensus LEF-/TCF-binding motifs upstream of a minimal c-fos promoter was used to create transgenic animals on a CD1 background.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| Considerations for Choosing Controls | ||
Related Strains
lacZ Expression Strains
View lacZ Expression Strains (178 strains)
003072 ALS/LtJ 006180 CD10/JlsJ 005052 PN/nBSwUmabJ 002746 SENCARA/PtJ 002747 SENCARB/PtJ 002748 SENCARC/PtJ 006135 STOCK Sgk3fz-ica/McirJ 003773 STOCK Tg(CAG-ECFP)CK6Nagy/J 005645 STOCK Tg(CAG-mRFP1)1F1Hadj/J 005667 STOCK Tg(Neurog3-cre)C1Able/J 003262 STOCK Tg(Trp53A135V)L3Ber/J 005104 STOCK Tg(tetO-HIST1H2BJ/GFP)47Efu/J 005699 STOCK Tg(tetO-Ipf1,EGFP)956.6Macd/J
003479 B6.C3-Tg(Fos-luc)1Rnd/J
Additional Web Information
Fluorescent Proteins/lacZ Systems
Genetic Quality Control Annual Report
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Tg(Fos-lacZ)34Efu/0
Background Not Specified
- skin/coat/nails phenotype
- abnormal epidermal layer morphology (MGI Ref ID J:102493)
- epidermal differentiation is delayed relative to wild-type
- abnormal keratinocyte differentiation (MGI Ref ID J:102493)
- mice show a decrease in relative number of terminally differentiatied keratinocytes
- absent sebaceous gland (MGI Ref ID J:102493)
- sebaceous glands are not detected at P9; however, they are visible in some follicles at P12
- thickened epidermis (MGI Ref ID J:102493)
- short hair (MGI Ref ID J:102493)
- transgenic mice have shorter hair than wild-type
- endocrine/exocrine gland phenotype
- absent sebaceous gland (MGI Ref ID J:102493)
- sebaceous glands are not detected at P9; however, they are visible in some follicles at P12
This mouse can be used to support research in many areas including:
lacZ relatedCell Biology Research
Signal Transduction
Dermatology Research
Other
Developmental Biology Research
Skin and Hair Texture Defects
Research Tools
lacZ Expression
Dermatology Research
Developmental Biology Research
Genetics Research (Tissue/Cell Markers)
Research Tools
lacZ Expression
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Tg(Fos-lacZ)34Efu | ||
|---|---|---|---|
| Allele Name | transgene insertion 34, Elaine Fuchs | ||
| Allele Type | Transgenic (Reporter) | ||
| Common Name(s) | TCF-betagal; TOPGAL; Top-Gal; | ||
| Mutation Made By | Elaine Fuchs, The Rockefeller University | ||
| Site of Expression | lacZ expression occurs during early embryonic development in a subset of pluripotent embryonic basel cells of the epithelium and dermis of developing hair follicles. lacZ expression disappears during formation of hair germ and then reappears at E16.5 in hair follicles until 18 days after birth. | ||
| Expressed Gene | lacZ, beta-galactosidase, E. coli | ||
| Promoter | Fos, FBJ osteosarcoma oncogene, rat | ||
| General Note |
Homozygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. Transgenic mice express beta-galactosidase in the presence of the lymphoid enhancer binding factor 1/transcription factor 3 (LEF1/TCF3) mediated signaling pathway and activated Beta-catenin (CATNB). Transgenic mice display Beta-galactosidase activity during early embryonic development in a subset of pluripotent embryonic basal cells of the epithelium and dermis of developing hair follicles. Beta-galactosidase activity is not detected in the next stage of hair follicle development, formation of hair germs. At E16.5, transgene activity reappears in hair follicles and is detectable until 18 days after birth. | ||
| Molecular Note | The transgene contains the lacZ gene under the control of a promoter consisting of three consensus LEF-/TCF-binding motifs upstream of a minimal Fos promoter. [MGI Ref ID J:55937] | ||
| Allele Symbol | Gnat2cpfl3 | ||
| Allele Name | cone photoreceptor function loss 3 | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | Gnat2; | ||
| Strain of Origin | various | ||
| Gene Symbol and Name | Gnat2, guanine nucleotide binding protein, alpha transducing 2 | ||
| Chromosome | 3 | ||
| Gene Common Name(s) | ACHM4; AW490837; GNATC; Gnat-2; Gt-2; Tcalpha; expressed sequence AW490837; | ||
| General Note |
This allele has been detected in the following strains either by genotyping or complementation testing: ALS/LtJ, SENCARA/PtJ, SENCARB/PtJ, SENCARC/PtJ, PN/nBSwUmabJ. (J:122428) Phenotypic Similarity to Human Syndrome in Orthologous Human Gene: OMIM +139340 ACHROMATOPSIA 4. | ||
| Molecular Note | A single nucleotide substitution of G to A at position 598 in exon 6. This mutation converts codon 200 from apartic acid to asparagine. [MGI Ref ID J:122428] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Generic LacZ Melt Curve Analysis, MCA, vers. 2
Generic LacZ, STD PCR, vers. 1
Helpful Links
Optimizing PCR Protocols
References
References
Selected Reference(s)
DasGupta R; Fuchs E. 1999. Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation. Development 126(20):4557-68. [PubMed: 10498690] [MGI Ref ID J:55937]
Additional References
Chang B; Dacey MS; Hawes NL; Hitchcock PF; Milam AH; Atmaca-Sonmez P; Nusinowitz S; Heckenlively JR. 2006. Cone photoreceptor function loss-3, a novel mouse model of achromatopsia due to a mutation in Gnat2. Invest Ophthalmol Vis Sci 47(11):5017-21. [PubMed: 17065522] [MGI Ref ID J:122428]
Gnat2cpfl3 relatedTg(Fos-lacZ)34Efu relatedAlexander JJ; Umino Y; Everhart D; Chang B; Min SH; Li Q; Timmers AM; Hawes NL; Pang JJ; Barlow RB; Hauswirth WW. 2007. Restoration of cone vision in a mouse model of achromatopsia. Nat Med 13(6):685-7. [PubMed: 17515894] [MGI Ref ID J:121897]
Chang B; Dacey MS; Hawes NL; Hitchcock PF; Milam AH; Atmaca-Sonmez P; Nusinowitz S; Heckenlively JR. 2006. Cone photoreceptor function loss-3, a novel mouse model of achromatopsia due to a mutation in Gnat2. Invest Ophthalmol Vis Sci 47(11):5017-21. [PubMed: 17065522] [MGI Ref ID J:122428]
Nusinowitz S; Ridder WH rd; Ramirez J. 2007. Temporal response properties of the primary and secondary rod-signaling pathways in normal and Gnat2 mutant mice. Exp Eye Res 84(6):1104-14. [PubMed: 17408617] [MGI Ref ID J:126462]
Umino Y; Solessio E; Barlow RB. 2008. Speed, spatial, and temporal tuning of rod and cone vision in mouse. J Neurosci 28(1):189-98. [PubMed: 18171936] [MGI Ref ID J:131050]
Beaudoin GM rd; Sisk JM; Coulombe PA; Thompson CC. 2005. Hairless triggers reactivation of hair growth by promoting Wnt signaling. Proc Natl Acad Sci U S A 102(41):14653-8. [PubMed: 16195376] [MGI Ref ID J:102493]
Bell SM; Schreiner CM; Wert SE; Mucenski ML; Scott WJ; Whitsett JA. 2008. R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis. Development 135(6):1049-58. [PubMed: 18256198] [MGI Ref ID J:131960]
Boras-Granic K; Chang H; Grosschedl R; Hamel PA. 2006. Lef1 is required for the transition of Wnt signaling from mesenchymal to epithelial cells in the mouse embryonic mammary gland. Dev Biol 295(1):219-31. [PubMed: 16678815] [MGI Ref ID J:110699]
Chen M; Zhu M; Awad H; Li TF; Sheu TJ; Boyce BF; Chen D; O'Keefe RJ. 2008. Inhibition of beta-catenin signaling causes defects in postnatal cartilage development. J Cell Sci 121(Pt 9):1455-65. [PubMed: 18397998] [MGI Ref ID J:139819]
Cheng SL; Shao JS; Cai J; Sierra OL; Towler DA. 2008. Msx2 exerts bone anabolism via canonical Wnt signaling. J Biol Chem 283(29):20505-22. [PubMed: 18487199] [MGI Ref ID J:138745]
Chu EY; Hens J; Andl T; Kairo A; Yamaguchi TP; Brisken C; Glick A; Wysolmerski JJ; Millar SE. 2004. Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis. Development 131(19):4819-29. [PubMed: 15342465] [MGI Ref ID J:98338]
Day TF; Guo X; Garrett-Beal L; Yang Y. 2005. Wnt/beta-Catenin Signaling in Mesenchymal Progenitors Controls Osteoblast and Chondrocyte Differentiation during Vertebrate Skeletogenesis. Dev Cell 8(5):739-50. [PubMed: 15866164] [MGI Ref ID J:98427]
De Langhe SP; Carraro G; Tefft D; Li C; Xu X; Chai Y; Minoo P; Hajihosseini MK; Drouin J; Kaartinen V; Bellusci S. 2008. Formation and Differentiation of Multiple Mesenchymal Lineages during Lung Development Is Regulated by beta-catenin Signaling. PLoS ONE 3(1):e1516. [PubMed: 18231602] [MGI Ref ID J:131535]
De Langhe SP; Carraro G; Warburton D; Hajihosseini MK; Bellusci S. 2006. Levels of mesenchymal FGFR2 signaling modulate smooth muscle progenitor cell commitment in the lung. Dev Biol 299(1):52-62. [PubMed: 16989802] [MGI Ref ID J:114396]
Gao J; DeRouen MC; Chen CH; Nguyen M; Nguyen NT; Ido H; Harada K; Sekiguchi K; Morgan BA; Miner JH; Oro AE; Marinkovich MP. 2008. Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis. Genes Dev 22(15):2111-24. [PubMed: 18676816] [MGI Ref ID J:139508]
Glass DA 2nd; Bialek P; Ahn JD; Starbuck M; Patel MS; Clevers H; Taketo MM; Long F; McMahon AP; Lang RA; Karsenty G. 2005. Canonical wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell 8(5):751-64. [PubMed: 15866165] [MGI Ref ID J:98430]
Hadjantonakis AK; Pisano E; Papaioannou VE. 2008. Tbx6 regulates left/right patterning in mouse embryos through effects on nodal cilia and perinodal signaling. PLoS ONE 3(6):e2511. [PubMed: 18575602] [MGI Ref ID J:137163]
Hatsell SJ; Cowin P. 2006. Gli3-mediated repression of Hedgehog targets is required for normal mammary development. Development 133(18):3661-70. [PubMed: 16914490] [MGI Ref ID J:112460]
Holmberg V; Jalanko A; Isosomppi J; Fabritius AL; Peltonen L; Kopra O. 2004. The mouse ortholog of the neuronal ceroid lipofuscinosis CLN5 gene encodes a soluble lysosomal glycoprotein expressed in the developing brain. Neurobiol Dis 16(1):29-40. [PubMed: 15207259] [MGI Ref ID J:91217]
Iwatsuki K; Liu HX; Gronder A; Singer MA; Lane TF; Grosschedl R; Mistretta CM; Margolskee RF. 2007. Wnt signaling interacts with Shh to regulate taste papilla development. Proc Natl Acad Sci U S A 104(7):2253-8. [PubMed: 17284610] [MGI Ref ID J:119729]
Jamora C; Lee P; Kocieniewski P; Azhar M; Hosokawa R; Chai Y; Fuchs E. 2005. A signaling pathway involving TGF-beta2 and snail in hair follicle morphogenesis. PLoS Biol 3(1):e11. [PubMed: 15630473] [MGI Ref ID J:97750]
Kim BM; Buchner G; Miletich I; Sharpe PT; Shivdasani RA. 2005. The stomach mesenchymal transcription factor Barx1 specifies gastric epithelial identity through inhibition of transient Wnt signaling. Dev Cell 8(4):611-22. [PubMed: 15809042] [MGI Ref ID J:98305]
Kim BM; Mao J; Taketo MM; Shivdasani RA. 2007. Phases of canonical Wnt signaling during the development of mouse intestinal epithelium. Gastroenterology 133(2):529-38. [PubMed: 17681174] [MGI Ref ID J:128278]
Kim BM; Miletich I; Mao J; McMahon AP; Sharpe PA; Shivdasani RA. 2007. Independent functions and mechanisms for homeobox gene Barx1 in patterning mouse stomach and spleen. Development 134(20):3603-13. [PubMed: 17855428] [MGI Ref ID J:128378]
Kousteni S; Almeida M; Han L; Bellido T; Jilka RL; Manolagas SC. 2007. Induction of osteoblast differentiation by selective activation of kinase-mediated actions of the estrogen receptor. Mol Cell Biol 27(4):1516-30. [PubMed: 17158928] [MGI Ref ID J:118245]
Koyama E; Shibukawa Y; Nagayama M; Sugito H; Young B; Yuasa T; Okabe T; Ochiai T; Kamiya N; Rountree RB; Kingsley DM; Iwamoto M; Enomoto-Iwamoto M; Pacifici M. 2008. A distinct cohort of progenitor cells participates in synovial joint and articular cartilage formation during mouse limb skeletogenesis. Dev Biol 316(1):62-73. [PubMed: 18295755] [MGI Ref ID J:135666]
Lewis SL; Khoo PL; Andrea De Young R; Bildsoe H; Wakamiya M; Behringer RR; Mukhopadhyay M; Westphal H; Tam PP. 2007. Genetic interaction of Gsc and Dkk1 in head morphogenesis of the mouse. Mech Dev 124(2):157-165. [PubMed: 17127040] [MGI Ref ID J:119933]
Lewis SL; Khoo PL; De Young RA; Steiner K; Wilcock C; Mukhopadhyay M; Westphal H; Jamieson RV; Robb L; Tam PP. 2008. Dkk1 and Wnt3 interact to control head morphogenesis in the mouse. Development 135(10):1791-801. [PubMed: 18403408] [MGI Ref ID J:134688]
Li TF; Chen D; Wu Q; Chen M; Sheu TJ; Schwarz EM; Drissi H; Zuscik M; O'Keefe RJ. 2006. Transforming growth factor-beta stimulates cyclin D1 expression through activation of beta-catenin signaling in chondrocytes. J Biol Chem 281(30):21296-304. [PubMed: 16690606] [MGI Ref ID J:116442]
Lien WH; Klezovitch O; Null M; Vasioukhin V. 2008. alphaE-catenin is not a significant regulator of beta-catenin signaling in the developing mammalian brain. J Cell Sci 121(Pt 9):1357-62. [PubMed: 18397997] [MGI Ref ID J:139820]
Lin C; Yin Y; Long F; Ma L. 2008. Tissue-specific requirements of beta-catenin in external genitalia development. Development 135(16):2815-25. [PubMed: 18635608] [MGI Ref ID J:139251]
Liu F; Chu EY; Watt B; Zhang Y; Gallant NM; Andl T; Yang SH; Lu MM; Piccolo S; Schmidt-Ullrich R; Taketo MM; Morrisey EE; Atit R; Dlugosz AA; Millar SE. 2008. Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis. Dev Biol 313(1):210-24. [PubMed: 18022614] [MGI Ref ID J:130228]
Liu F; Thirumangalathu S; Gallant NM; Yang SH; Stoick-Cooper CL; Reddy ST; Andl T; Taketo MM; Dlugosz AA; Moon RT; Barlow LA; Millar SE. 2007. Wnt-beta-catenin signaling initiates taste papilla development. Nat Genet 39(1):106-12. [PubMed: 17128274] [MGI Ref ID J:117476]
Liu H; Fergusson MM; Castilho RM; Liu J; Cao L; Chen J; Malide D; Rovira II; Schimel D; Kuo CJ; Gutkind JS; Hwang PM; Finkel T. 2007. Augmented Wnt signaling in a mammalian model of accelerated aging. Science 317(5839):803-6. [PubMed: 17690294] [MGI Ref ID J:123536]
Lobov IB; Rao S; Carroll TJ; Vallance JE; Ito M; Ondr JK; Kurup S; Glass DA; Patel MS; Shu W; Morrisey EE; McMahon AP; Karsenty G; Lang RA. 2005. WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature. Nature 437(7057):417-21. [PubMed: 16163358] [MGI Ref ID J:101493]
Miller LA; Smith AN; Taketo MM; Lang RA. 2006. Optic cup and facial patterning defects in ocular ectoderm beta-catenin gain-of-function mice. BMC Dev Biol 6:14. [PubMed: 16539717] [MGI Ref ID J:109351]
Nemeth MJ; Kirby MR; Bodine DM. 2006. Hmgb3 regulates the balance between hematopoietic stem cell self-renewal and differentiation. Proc Natl Acad Sci U S A 103(37):13783-8. [PubMed: 16945912] [MGI Ref ID J:113745]
Okubo T; Pevny LH; Hogan BL. 2006. Sox2 is required for development of taste bud sensory cells. Genes Dev 20(19):2654-9. [PubMed: 17015430] [MGI Ref ID J:112945]
Pan Y; Woodbury A; Esko JD; Grobe K; Zhang X. 2006. Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development. Development 133(24):4933-44. [PubMed: 17107998] [MGI Ref ID J:119651]
Pasca di Magliano M; Biankin AV; Heiser PW; Cano DA; Gutierrez PJ; Deramaudt T; Segara D; Dawson AC; Kench JG; Henshall SM; Sutherland RL; Dlugosz A; Rustgi AK; Hebrok M. 2007. Common activation of canonical wnt signaling in pancreatic adenocarcinoma. PLoS ONE 2(11):e1155. [PubMed: 17982507] [MGI Ref ID J:130408]
Pierreux CE; Poll AV; Kemp CR; Clotman F; Maestro MA; Cordi S; Ferrer J; Leyns L; Rousseau GG; Lemaigre FP. 2006. The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse. Gastroenterology 130(2):532-41. [PubMed: 16472605] [MGI Ref ID J:125042]
Placencio VR; Sharif-Afshar AR; Li X; Huang H; Uwamariya C; Neilson EG; Shen MM; Matusik RJ; Hayward SW; Bhowmick NA. 2008. Stromal transforming growth factor-beta signaling mediates prostatic response to androgen ablation by paracrine Wnt activity. Cancer Res 68(12):4709-18. [PubMed: 18559517] [MGI Ref ID J:138897]
Plikus MV; Mayer JA; de la Cruz D; Baker RE; Maini PK; Maxson R; Chuong CM. 2008. Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration. Nature 451(7176):340-4. [PubMed: 18202659] [MGI Ref ID J:131404]
Rao S; Lobov IB; Vallance JE; Tsujikawa K; Shiojima I; Akunuru S; Walsh K; Benjamin LE; Lang RA. 2007. Obligatory participation of macrophages in an angiopoietin 2-mediated cell death switch. Development 134(24):4449-58. [PubMed: 18039971] [MGI Ref ID J:135278]
Rhee H; Polak L; Fuchs E. 2006. Lhx2 maintains stem cell character in hair follicles. Science 312(5782):1946-9. [PubMed: 16809539] [MGI Ref ID J:110119]
Riccomagno MM; Takada S; Epstein DJ. 2005. Wnt-dependent regulation of inner ear morphogenesis is balanced by the opposing and supporting roles of Shh. Genes Dev 19(13):1612-23. [PubMed: 15961523] [MGI Ref ID J:99408]
Shao JS; Cheng SL; Pingsterhaus JM; Charlton-Kachigian N; Loewy AP; Towler DA. 2005. Msx2 promotes cardiovascular calcification by activating paracrine Wnt signals. J Clin Invest 115(5):1210-20. [PubMed: 15841209] [MGI Ref ID J:98092]
Shu W; Guttentag S; Wang Z; Andl T; Ballard P; Lu MM; Piccolo S; Birchmeier W; Whitsett JA; Millar SE; Morrisey EE. 2005. Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung. Dev Biol 283(1):226-39. [PubMed: 15907834] [MGI Ref ID J:99391]
Smith AN; Miller LA; Song N; Taketo MM; Lang RA. 2005. The duality of beta-catenin function: a requirement in lens morphogenesis and signaling suppression of lens fate in periocular ectoderm. Dev Biol 285(2):477-89. [PubMed: 16102745] [MGI Ref ID J:101264]
Trowbridge JJ; Scott MP; Bhatia M. 2006. Hedgehog modulates cell cycle regulators in stem cells to control hematopoietic regeneration. Proc Natl Acad Sci U S A 103(38):14134-9. [PubMed: 16968775] [MGI Ref ID J:113717]
Veltmaat JM; Relaix F; Le LT; Kratochwil K; Sala FG; van Veelen W; Rice R; Spencer-Dene B; Mailleux AA; Rice DP; Thiery JP; Bellusci S. 2006. Gli3-mediated somitic Fgf10 expression gradients are required for the induction and patterning of mammary epithelium along the embryonic axes. Development 133(12):2325-35. [PubMed: 16720875] [MGI Ref ID J:109476]
Yu HM; Jerchow B; Sheu TJ; Liu B; Costantini F; Puzas JE; Birchmeier W; Hsu W. 2005. The role of Axin2 in calvarial morphogenesis and craniosynostosis. Development 132(8):1995-2005. [PubMed: 15790973] [MGI Ref ID J:98523]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX12
Colony Maintenance
Breeding & Husbandry This strain is maintained as a hemizygote on a stock CD1 background. Coat color expected from breeding:Albino Mating System +/+ sibling x Hemizygote (Female x Male) Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Weeks of Age Price* Gender Genotypes Provided Individual Mouse Price $232.00 Female or Male Hemizygous for Tg(Fos-lacZ)34Efu *Price(s) in US dollars ($)
Pairs /Price* Pair Genotype $284.25 Hemizygous for Tg(Fos-lacZ)34Efu x Noncarrier $284.25 Noncarrier x Hemizygous for Tg(Fos-lacZ)34Efu
Additional Supply Details
| Supply Notes |
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| Pricing for International shipping destinations |
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Weeks of Age Price* Gender Genotypes Provided Individual Mouse Price $301.60 Female or Male Hemizygous for Tg(Fos-lacZ)34Efu *Price(s) in US dollars ($)
Pairs /Price* Pair Genotype $369.60 Hemizygous for Tg(Fos-lacZ)34Efu x Noncarrier $369.60 Noncarrier x Hemizygous for Tg(Fos-lacZ)34Efu
Additional Supply Details
| Supply Notes |
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement. |
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| Supply Notes |
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| Important Note | This strain may be homozygous for Gnat2cpfl3, cone photoreceptor function loss 3, which affects bright light (photopic) vision. |
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
General Terms and Conditions
See Terms of Use
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
Purchasing Information
JAX® Mice Orders
Surgical Services
Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form
Terms of Use
Terms of Use
General Terms and Conditions
For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.
Contact information
General inquiries
Contracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice & Services Conditions of Use
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MICE and biological materials are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to The Jackson Laboratory’s MICE, products and services. In addition, special terms and conditions of sale of certain MICE, products and services may be set forth separately in The Jackson Laboratory web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, products and services by The Jackson Laboratory, and by its licensees and distributors.
Acceptance of delivery of MICE, products or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on The Jackson Laboratory, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, products services by The Jackson Laboratory.