Additional References

't Hoen PA; Van der Lans CA; Van Eck M; Bijsterbosch MK; Van Berkel TJ; Twisk J. 2003. Aorta of ApoE-deficient mice responds to atherogenic stimuli by a prelesional increase and subsequent decrease in the expression of antioxidant enzymes. Circ Res 93(3):262-9. [PubMed: 12829615]  [MGI Ref ID J:115676]

Accad M; Smith SJ; Newland DL; Sanan DA; King LE Jr; Linton MF; Fazio S; Farese RV Jr. 2000. Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1 [see comments] J Clin Invest 105(6):711-9. [PubMed: 10727439]  [MGI Ref ID J:61147]

Agrawal S; Febbraio M; Podrez E; Cathcart MK; Stark GR; Chisolm GM. 2007. Signal transducer and activator of transcription 1 is required for optimal foam cell formation and atherosclerotic lesion development. Circulation 115(23):2939-47. [PubMed: 17533179]  [MGI Ref ID J:137115]

Aihara K; Azuma H; Akaike M; Ikeda Y; Sata M; Takamori N; Yagi S; Iwase T; Sumitomo Y; Kawano H; Yamada T; Fukuda T; Matsumoto T; Sekine K; Sato T; Nakamichi Y; Yamamoto Y; Yoshimura K; Watanabe T; Nakamura T; Oomizu A; Tsukada M; Hayashi H; Sudo T; KatoS; Matsumoto T. 2007. Strain-dependent embryonic lethality and exaggerated vascular remodeling in heparin cofactor II-deficient mice. J Clin Invest 117(6):1514-26. [PubMed: 17549254]  [MGI Ref ID J:122173]

Aikawa E; Nahrendorf M; Sosnovik D; Lok VM; Jaffer FA; Aikawa M; Weissleder R. 2007. Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease. Circulation 115(3):377-86. [PubMed: 17224478]  [MGI Ref ID J:130156]

Alexander MR; Knowles JW; Nishikimi T; Maeda N. 2003. Increased atherosclerosis and smooth muscle cell hypertrophy in natriuretic peptide receptor A-/-apolipoprotein E-/- mice. Arterioscler Thromb Vasc Biol 23(6):1077-82. [PubMed: 12702516]  [MGI Ref ID J:103054]

Ali K; Middleton M; Pure E; Rader DJ. 2005. Apolipoprotein E suppresses the type I inflammatory response in vivo. Circ Res 97(9):922-7. [PubMed: 16179587]  [MGI Ref ID J:114634]

Alp NJ; McAteer MA; Khoo J; Choudhury RP; Channon KM. 2004. Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice. Arterioscler Thromb Vasc Biol 24(3):445-50. [PubMed: 14707037]  [MGI Ref ID J:102062]

Amigo L; Quinones V; Mardones P; Zanlungo S; Miquel JF; Nervi F; Rigotti A. 2000. Impaired biliary cholesterol secretion and decreased gallstone formation in apolipoprotein E-deficient mice fed a high-cholesterol diet. Gastroenterology 118(4):772-9. [PubMed: 10734029]  [MGI Ref ID J:107676]

Anderson DR; Tsutsui JM; Xie F; Radio SJ; Porter TR. 2007. The role of complement in the adherence of microbubbles to dysfunctional arterial endothelium and atherosclerotic plaque. Cardiovasc Res 73(3):597-606. [PubMed: 17196951]  [MGI Ref ID J:119533]

Anderson R; Barnes JC; Bliss TV; Cain DP; Cambon K; Davies HA; Errington ML; Fellows LA; Gray RA; Hoh T; Stewart M; Large CH; Higgins GA. 1998. Behavioural, physiological and morphological analysis of a line of apolipoprotein E knockout mouse. Neuroscience 85(1):93-110. [PubMed: 9607706]  [MGI Ref ID J:118390]

Anderson R; Higgins GA. 1997. Absence of central cholinergic deficits in ApoE knockout mice. Psychopharmacology (Berl) 132(2):135-44. [PubMed: 9266610]  [MGI Ref ID J:127860]

Ando Y; Shimizugawa T; Takeshita S; Ono M; Shimamura M; Koishi R; Furukawa H. 2003. A decreased expression of angiopoietin-like 3 is protective against atherosclerosis in apoE-deficient mice. J Lipid Res 44(6):1216-23. [PubMed: 12671033]  [MGI Ref ID J:84022]

Angeli V; Llodra J; Rong JX; Satoh K; Ishii S; Shimizu T; Fisher EA; Randolph GJ. 2004. Dyslipidemia associated with atherosclerotic disease systemically alters dendritic cell mobilization. Immunity 21(4):561-74. [PubMed: 15485633]  [MGI Ref ID J:93917]

Aprahamian T; Rifkin I; Bonegio R; Hugel B; Freyssinet JM; Sato K; Castellot JJ Jr; Walsh K. 2004. Impaired Clearance of Apoptotic Cells Promotes Synergy between Atherogenesis and Autoimmune Disease. J Exp Med 199(8):1121-31. [PubMed: 15096538]  [MGI Ref ID J:91058]

Atkinson RD; Coenen KR; Plummer MR; Gruen ML; Hasty AH. 2008. Macrophage-derived apolipoprotein E ameliorates dyslipidemia and atherosclerosis in obese apolipoprotein E-deficient mice. Am J Physiol Endocrinol Metab 294(2):E284-90. [PubMed: 18029445]  [MGI Ref ID J:133332]

Auger A; Truong TQ; Rhainds D; Lapointe J; Letarte F; Brissette L. 2001. Low and high density lipoprotein metabolism in primary cultures of hepatic cells from normal and apolipoprotein E knockout mice. Eur J Biochem 268(8):2322-30. [PubMed: 11298750]  [MGI Ref ID J:115588]

Babaev VR; Ding L; Reese J; Morrow JD; Breyer MD; Dey SK; Fazio S; Linton MF. 2006. Cyclooxygenase-1 deficiency in bone marrow cells increases early atherosclerosis in apolipoprotein E- and low-density lipoprotein receptor-null mice. Circulation 113(1):108-17. [PubMed: 16380543]  [MGI Ref ID J:121507]

Baldan A; Pei L; Lee R; Tarr P; Tangirala RK; Weinstein MM; Frank J; Li AC; Tontonoz P; Edwards PA. 2006. Impaired development of atherosclerosis in hyperlipidemic Ldlr-/- and ApoE-/- mice transplanted with Abcg1-/- bone marrow. Arterioscler Thromb Vasc Biol 26(10):2301-7. [PubMed: 16888235]  [MGI Ref ID J:128048]

Bales KR; Verina T; Cummins DJ; Du Y; Dodel RC; Saura J; Fishman CE; DeLong CA; Piccardo P; Petegnief V; Ghetti B; Paul SM. 1999. Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A 96(26):15233-8. [PubMed: 10611368]  [MGI Ref ID J:59078]

Bales KR; Verina T; Dodel RC; Du Y; Altstiel L; Bender M; Hyslop P; Johnstone EM; Little SP; Cummins DJ; Piccardo P; Ghetti B; Paul SM. 1997. Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition [letter] [see comments] Nat Genet 17(3):263-4. [PubMed: 9354781]  [MGI Ref ID J:43845]

Barile GR; Pachydaki SI; Tari SR; Lee SE; Donmoyer CM; Ma W; Rong LL; Buciarelli LG; Wendt T; Horig H; Hudson BI; Qu W; Weinberg AD; Yan SF; Schmidt AM. 2005. The RAGE axis in early diabetic retinopathy. Invest Ophthalmol Vis Sci 46(8):2916-24. [PubMed: 16043866]  [MGI Ref ID J:103714]

Barlic J; Murphy PM. 2007. Chemokine regulation of atherosclerosis. J Leukoc Biol 82(2):226-36. [PubMed: 17329566]  [MGI Ref ID J:123530]

Barry-Lane PA; Patterson C; van der Merwe M; Hu Z; Holland SM; Yeh ET; Runge MS. 2001. p47phox is required for atherosclerotic lesion progression in ApoE(-/-) mice. J Clin Invest 108(10):1513-22. [PubMed: 11714743]  [MGI Ref ID J:111638]

Barton M; Haudenschild CC; d'Uscio LV; Shaw S; Munter K; Luscher TF. 1998. Endothelin ETA receptor blockade restores NO-mediated endothelial function and inhibits atherosclerosis in apolipoprotein E-deficient mice. Proc Natl Acad Sci U S A 95(24):14367-72. [PubMed: 9826706]  [MGI Ref ID J:51282]

Bates KA; Fonte J; Robertson TA; Martins RN; Harvey AR. 2002. Chronic gliosis triggers Alzheimer's disease-like processing of amyloid precursor protein. Neuroscience 113(4):785-96. [PubMed: 12182886]  [MGI Ref ID J:120711]

Baumgartl J; Baudler S; Scherner M; Babaev V; Makowski L; Suttles J; McDuffie M; Tobe K; Kadowaki T; Fazio S; Kahn CR; Hotamisligil GS; Krone W; Linton M; Bruning JC. 2006. Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis. Cell Metab 3(4):247-56. [PubMed: 16581002]  [MGI Ref ID J:129654]

Bechtholt AJ; Smith R; Raber J; Cunningham CL. 2004. Enhanced ethanol-, but not cocaine-induced, conditioned place preference in Apoe(-/-) mice. Pharmacol Biochem Behav 77(4):783-92. [PubMed: 15099924]  [MGI Ref ID J:102259]

Beckers L; Heeneman S; Wang L; Burkly L; Rousch M; Davidson N; Gijbels M; de Winther M; Daemen M; Lutgens E. 2007. Disruption of hedgehog signalling in ApoE - /- mice reduces plasma lipid levels, but increases atherosclerosis due to enhanced lipid uptake by macrophages. J Pathol 212(4):420-8. [PubMed: 17573667]  [MGI Ref ID J:122864]

Bengtsson E; To F; Hakansson K; Grubb A; Branen L; Nilsson J; Jovinge S. 2005. Lack of the cysteine protease inhibitor cystatin C promotes atherosclerosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 25(10):2151-6. [PubMed: 16051881]  [MGI Ref ID J:114346]

Bennett BJ; Scatena M; Kirk EA; Rattazzi M; Varon RM; Averill M; Schwartz SM; Giachelli CM; Rosenfeld ME. 2006. Osteoprotegerin inactivation accelerates advanced atherosclerotic lesion progression and calcification in older ApoE-/- mice. Arterioscler Thromb Vasc Biol 26(9):2117-24. [PubMed: 16840715]  [MGI Ref ID J:128053]

Berbee JF; van der Hoogt CC; Sundararaman D; Havekes LM; Rensen PC. 2005. Severe hypertriglyceridemia in human APOC1 transgenic mice is caused by apoC-I-induced inhibition of LPL. J Lipid Res 46(2):297-306. [PubMed: 15576844]  [MGI Ref ID J:96691]

Bernhagen J; Krohn R; Lue H; Gregory JL; Zernecke A; Koenen RR; Dewor M; Georgiev I; Schober A; Leng L; Kooistra T; Fingerle-Rowson G; Ghezzi P; Kleemann R; McColl SR; Bucala R; Hickey MJ; Weber C. 2007. MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment. Nat Med 13(5):587-596. [PubMed: 17435771]  [MGI Ref ID J:121807]

Bhattacharjee PS; Neumann DM; Stark D; Thompson HW; Hill JM. 2006. Apolipoprotein E modulates establishment of HSV-1 latency and survival in a mouse ocular model. Curr Eye Res 31(9):703-8. [PubMed: 16966142]  [MGI Ref ID J:119878]

Biswas SK; Newby DE; Rahman I; Megson IL. 2005. Depressed glutathione synthesis precedes oxidative stress and atherogenesis in Apo-E(-/-) mice. Biochem Biophys Res Commun 338(3):1368-73. [PubMed: 16263083]  [MGI Ref ID J:103465]

Bjorkbacka H; Kunjathoor VV; Moore KJ; Koehn S; Ordija CM; Lee MA; Means T; Halmen K; Luster AD; Golenbock DT; Freeman MW. 2004. Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways. Nat Med 10(4):416-21. [PubMed: 15034566]  [MGI Ref ID J:90091]

Blasiole DA; Oler AT; Attie AD. 2008. Regulation of ApoB secretion by the low density lipoprotein receptor requires exit from the endoplasmic reticulum and interaction with ApoE or ApoB. J Biol Chem 283(17):11374-81. [PubMed: 18272520]  [MGI Ref ID J:136523]

Bobkova D; Honsova E; Kovar J; Poledne R. 2004. Effect of diets on lipoprotein concentrations in heterozygous apolipoprotein E-deficient mice. Physiol Res 53(6):635-43. [PubMed: 15588132]  [MGI Ref ID J:102284]

Bobryshev YV; Babaev VR; Lord RS; Watanabe T. 1999. Ultrastructural identification of cells with dendritic cell appearance in atherosclerotic aorta of apolipoprotein E deficient mice J Submicrosc Cytol Pathol 31(4):527-31. [PubMed: 10685393]  [MGI Ref ID J:60456]

Bodary PF; Shen Y; Vargas FB; Bi X; Ostenso KA; Gu S; Shayman JA; Eitzman DT. 2005. Alpha-galactosidase A deficiency accelerates atherosclerosis in mice with apolipoprotein E deficiency Circulation 111(5):629-32. [PubMed: 15668341]  [MGI Ref ID J:108541]

Boesten LS; Zadelaar AS; van Nieuwkoop A; Hu L; Jonkers J; van de Water B; Gijbels MJ; van der Made I; de Winther MP; Havekes LM; van Vlijmen BJ. 2006. Macrophage retinoblastoma deficiency leads to enhanced atherosclerosis development in ApoE-deficient mice. FASEB J 20(7):953-5. [PubMed: 16585057]  [MGI Ref ID J:111494]

Boisvert WA; Black AS; Curtiss LK. 1999. ApoA1 reduces free cholesterol accumulation in atherosclerotic lesions of ApoE-deficient mice transplanted with ApoE-expressing macrophages. Arterioscler Thromb Vasc Biol 19(3):525-30. [PubMed: 10073953]  [MGI Ref ID J:55595]

Boord JB; Maeda K; Makowski L; Babaev VR; Fazio S; Linton MF; Hotamisligil GS. 2002. Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia. Arterioscler Thromb Vasc Biol 22(10):1686-91. [PubMed: 12377750]  [MGI Ref ID J:103224]

Boord JB; Maeda K; Makowski L; Babaev VR; Fazio S; Linton MF; Hotamisligil GS. 2004. Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice. Circulation 110(11):1492-8. [PubMed: 15353487]  [MGI Ref ID J:102223]

Boring L; Gosling J; Cleary M; Charo IF. 1998. Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis. Nature 394(6696):894-7. [PubMed: 9732872]  [MGI Ref ID J:111471]

Bourdillon MC; Poston RN; Covacho C; Chignier E; Bricca G; McGregor JL. 2000. ICAM-1 deficiency reduces atherosclerotic lesions in double-knockout mice (ApoE(-/-)/ICAM-1(-/-)) fed a fat or a chow diet. Arterioscler Thromb Vasc Biol 20(12):2630-5. [PubMed: 11116064]  [MGI Ref ID J:103384]

Bradley MN; Hong C; Chen M; Joseph SB; Wilpitz DC; Wang X; Lusis AJ; Collins A; Hseuh WA; Collins JL; Tangirala RK; Tontonoz P. 2007. Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE. J Clin Invest 117(8):2337-46. [PubMed: 17657314]  [MGI Ref ID J:123957]

Branen L; Hovgaard L; Nitulescu M; Bengtsson E; Nilsson J; Jovinge S. 2004. Inhibition of tumor necrosis factor-alpha reduces atherosclerosis in apolipoprotein E knockout mice. Arterioscler Thromb Vasc Biol 24(11):2137-42. [PubMed: 15345516]  [MGI Ref ID J:103699]

Braunersreuther V; Zernecke A; Arnaud C; Liehn EA; Steffens S; Shagdarsuren E; Bidzhekov K; Burger F; Pelli G; Luckow B; Mach F; Weber C. 2007. Ccr5 but not Ccr1 deficiency reduces development of diet-induced atherosclerosis in mice. Arterioscler Thromb Vasc Biol 27(2):373-9. [PubMed: 17138939]  [MGI Ref ID J:128063]

Brecht WJ; Harris FM; Chang S; Tesseur I; Yu GQ; Xu Q; Dee Fish J; Wyss-Coray T; Buttini M; Mucke L; Mahley RW; Huang Y. 2004. Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice. J Neurosci 24(10):2527-34. [PubMed: 15014128]  [MGI Ref ID J:90126]

Bro S; Borup R; Andersen CB; Moeller F; Olgaard K; Nielsen LB. 2006. Uremia-specific effects in the arterial media during development of uremic atherosclerosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 26(3):570-5. [PubMed: 16373611]  [MGI Ref ID J:127966]

Broedl UC; Maugeais C; Millar JS; Jin W; Moore RE; Fuki IV; Marchadier D; Glick JM; Rader DJ. 2004. Endothelial lipase promotes the catabolism of ApoB-containing lipoproteins. Circ Res 94(12):1554-61. [PubMed: 15117821]  [MGI Ref ID J:100064]

Brown MD; Jin L; Jien ML; Matsumoto AH; Helm GA; Lusis AJ; Frank JS; Shi W. 2004. Lipid retention in the arterial wall of two mouse strains with different atherosclerosis susceptibility. J Lipid Res 45(6):1155-61. [PubMed: 15105414]  [MGI Ref ID J:89769]

Bruemmer D; Collins AR; Noh G; Wang W; Territo M; Arias-Magallona S; Fishbein MC; Blaschke F; Kintscher U; Graf K; Law RE; Hsueh WA. 2003. Angiotensin II-accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice. J Clin Invest 112(9):1318-31. [PubMed: 14597759]  [MGI Ref ID J:86531]

Burgos JS; Ramirez C; Sastre I; Alfaro JM; Valdivieso F. 2005. Herpes simplex virus type 1 infection via the bloodstream with apolipoprotein E dependence in the gonads is influenced by gender. J Virol 79(3):1605-12. [PubMed: 15650186]  [MGI Ref ID J:95551]

Burleigh ME; Babaev VR; Oates JA; Harris RC; Gautam S; Riendeau D; Marnett LJ; Morrow JD; Fazio S; Linton MF. 2002. Cyclooxygenase-2 promotes early atherosclerotic lesion formation in LDL receptor-deficient mice. Circulation 105(15):1816-23. [PubMed: 11956125]  [MGI Ref ID J:103220]

Burleigh ME; Babaev VR; Yancey PG; Major AS; McCaleb JL; Oates JA; Morrow JD; Fazio S; Linton MF. 2005. Cyclooxygenase-2 promotes early atherosclerotic lesion formation in ApoE-deficient and C57BL/6 mice. J Mol Cell Cardiol 39(3):443-52. [PubMed: 16040051]  [MGI Ref ID J:103979]

Burnett MS; Gaydos CA; Madico GE; Glad SM; Paigen B; Quinn TC; Epstein SE. 2001. Atherosclerosis in apoE knockout mice infected with multiple pathogens. J Infect Dis 183(2):226-231. [PubMed: 11120928]  [MGI Ref ID J:66879]

Burton CA; Patel S; Mundt S; Hassing H; Zhang D; Hermanowski-Vosatka A; Wright SD; Chao YS; Detmers PA; Sparrow CP. 2002. Deficiency in sPLA(2) does not affect HDL levels or atherosclerosis in mice. Biochem Biophys Res Commun 294(1):88-94. [PubMed: 12054745]  [MGI Ref ID J:77028]

Buttini M; Orth M; Bellosta S; Akeefe H; Pitas RE; Wyss-Coray T; Mucke L; Mahley RW. 1999. Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration. J Neurosci 19(12):4867-80. [PubMed: 10366621]  [MGI Ref ID J:55835]

Buttini M; Yu GQ; Shockley K; Huang Y; Jones B; Masliah E; Mallory M; Yeo T; Longo FM; Mucke L. 2002. Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation. J Neurosci 22(24):10539-48. [PubMed: 12486146]  [MGI Ref ID J:129689]

Buzello M; Tornig J; Faulhaber J; Ehmke H; Ritz E; Amann K. 2003. The apolipoprotein e knockout mouse: a model documenting accelerated atherogenesis in uremia. J Am Soc Nephrol 14(2):311-6. [PubMed: 12538731]  [MGI Ref ID J:103173]

Cabana VG; Feng N; Reardon CA; Lukens J; Webb NR; de Beer FC; Getz GS. 2004. Influence of apoA-I and apoE on the formation of serum amyloid A-containing lipoproteins in vivo and in vitro. J Lipid Res 45(2):317-25. [PubMed: 14595002]  [MGI Ref ID J:121045]

Cain WJ; Millar JS; Himebauch AS; Tietge UJ; Maugeais C; Usher D; Rader DJ. 2005. Lipoprotein [a] is cleared from the plasma primarily by the liver in a process mediated by apolipoprotein [a]. J Lipid Res 46(12):2681-91. [PubMed: 16150825]  [MGI Ref ID J:106146]

Cakir Y; Yang Z; Knight CA; Pompilius M; Westbrook D; Bailey SM; Pinkerton KE; Ballinger SW. 2007. Effect of alcohol and tobacco smoke on mtDNA damage and atherogenesis. Free Radic Biol Med 43(9):1279-88. [PubMed: 17893041]  [MGI Ref ID J:125300]

Caligiuri G; Groyer E; Khallou-Laschet J; Al Haj Zen A; Sainz J; Urbain D; Gaston AT; Lemitre M; Nicoletti A; Lafont A. 2005. Reduced immunoregulatory CD31+ T cells in the blood of atherosclerotic mice with plaque thrombosis. Arterioscler Thromb Vasc Biol 25(8):1659-64. [PubMed: 15933243]  [MGI Ref ID J:114337]

Caligiuri G; Levy B; Pernow J; Thoren P; Hansson GK. 1999. Myocardial infarction mediated by endothelin receptor signaling in hypercholesterolemic mice. Proc Natl Acad Sci U S A 96(12):6920-4. [PubMed: 10359814]  [MGI Ref ID J:55973]

Caligiuri G; Nicoletti A; Poirier B; Hansson GK. 2002. Protective immunity against atherosclerosis carried by B cells of hypercholesterolemic mice. J Clin Invest 109(6):745-53. [PubMed: 11901183]  [MGI Ref ID J:75627]

Caligiuri G; Rudling M; Ollivier V; Jacob MP; Michel JB; Hansson GK; Nicoletti A. 2003. Interleukin-10 deficiency increases atherosclerosis, thrombosis, and low-density lipoproteins in apolipoprotein E knockout mice. Mol Med 9(1-2):10-7. [PubMed: 12765335]  [MGI Ref ID J:105858]

Calleja L; Paris MA; Paul A; Vilella E; Joven J; Jimenez A; Beltran G; Uceda M; Maeda N; Osada J. 1999. Low-cholesterol and high-fat diets reduce atherosclerotic lesion development in ApoE-knockout mice. Arterioscler Thromb Vasc Biol 19(10):2368-75. [PubMed: 10521366]  [MGI Ref ID J:59716]

Cambon K; Davies HA; Stewart MG. 2000. Synaptic loss is accompanied by an increase in synaptic area in the dentate gyrus of aged human apolipoprotein E4 transgenic mice. Neuroscience 97(4):685-92. [PubMed: 10842013]  [MGI Ref ID J:118049]

Canault M; Peiretti F; Poggi M; Mueller C; Kopp F; Bonardo B; Bastelica D; Nicolay A; Alessi MC; Nalbone G. 2008. Progression of atherosclerosis in ApoE-deficient mice that express distinct molecular forms of TNF-alpha. J Pathol 214(5):574-83. [PubMed: 18247429]  [MGI Ref ID J:133510]

Cao RY; Adams MA; Habenicht AJ; Funk CD. 2007. Angiotensin II-induced abdominal aortic aneurysm occurs independently of the 5-lipoxygenase pathway in apolipoprotein E-deficient mice. Prostaglandins Other Lipid Mediat 84(1-2):34-42. [PubMed: 17643886]  [MGI Ref ID J:129321]

Carlson GA; Borchelt DR; Dake A; Turner S; Danielson V; Coffin JD; Eckman C; Meiners J; Nilsen SP; Younkin SG; Hsiao KK. 1997. Genetic modification of the phenotypes produced by amyloid precursor protein overexpression in transgenic mice. Hum Mol Genet 6(11):1951-9. [PubMed: 9302276]  [MGI Ref ID J:43446]

Castellani LW; Nguyen CN; Charugundla S; Weinstein MM; Doan CX; Blaner WS; Wongsiriroj N; Lusis AJ. 2008. Apolipoprotein AII is a regulator of very low density lipoprotein metabolism and insulin resistance. J Biol Chem 283(17):11633-44. [PubMed: 18160395]  [MGI Ref ID J:136532]

Catanozi S; Rocha JC; Passarelli M; Guzzo ML; Alves C; Furukawa LN; Nunes VS; Nakandakare ER; Heimann JC; Quintao EC. 2003. Dietary sodium chloride restriction enhances aortic wall lipid storage and raises plasma lipid concentration in LDL receptor knockout mice. J Lipid Res 44(4):727-32. [PubMed: 12562870]  [MGI Ref ID J:120709]

Champagne D; Dupuy JB; Rochford J; Poirier J. 2002. Apolipoprotein E knockout mice display procedural deficits in the Morris water maze: analysis of learning strategies in three versions of the task. Neuroscience 114(3):641-54. [PubMed: 12220566]  [MGI Ref ID J:120203]

Chang JD; Sukhova GK; Libby P; Schvartz E; Lichtenstein AH; Field SJ; Kennedy C; Madhavarapu S; Luo J; Wu D; Cantley LC. 2007. Deletion of the phosphoinositide 3-kinase p110gamma gene attenuates murine atherosclerosis. Proc Natl Acad Sci U S A 104(19):8077-82. [PubMed: 17483449]  [MGI Ref ID J:121582]

Chang S; Zhang SH; Maeda N; Borensztajn J. 1994. Hepatic clearance of chylomicron remnants in mice lacking apoprotein E. Biochim Biophys Acta 1215(1-2):205-8. [PubMed: 7948005]  [MGI Ref ID J:21599]

Chen J; Kuhlencordt PJ; Astern J; Gyurko R; Huang PL. 2001. Hypertension does not account for the accelerated atherosclerosis and development of aneurysms in male apolipoprotein e/endothelial nitric oxide synthase double knockout mice. Circulation 104(20):2391-4. [PubMed: 11705813]  [MGI Ref ID J:103382]

Chen WY; Cheng BC; Jiang MJ; Hsieh MY; Chang MS. 2006. IL-20 is expressed in atherosclerosis plaques and promotes atherosclerosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 26(9):2090-5. [PubMed: 16778121]  [MGI Ref ID J:127995]

Chen Y; Zhu J; Lum PY; Yang X; Pinto S; MacNeil DJ; Zhang C; Lamb J; Edwards S; Sieberts SK; Leonardson A; Castellini LW; Wang S; Champy MF; Zhang B; Emilsson V; Doss S; Ghazalpour A; Horvath S; Drake TA; Lusis AJ; Schadt EE. 2008. Variations in DNA elucidate molecular networks that cause disease. Nature 452(7186):429-35. [PubMed: 18344982]  [MGI Ref ID J:134171]

Chen Z; Fitzgerald RL; Li G; Davidson NO; Schonfeld G. 2004. Hepatic secretion of apoB-100 is impaired in hypobetalipoproteinemic mice with an apoB-38.9-specifying allele. J Lipid Res 45(1):155-63. [PubMed: 13130124]  [MGI Ref ID J:87974]

Chen Z; Fitzgerald RL; Saffitz JE; Semenkovich CF; Schonfeld G. 2003. Amino terminal 38.9% of apolipoprotein B-100 is sufficient to support cholesterol-rich lipoprotein production and atherosclerosis. Arterioscler Thromb Vasc Biol 23(4):668-74. [PubMed: 12615667]  [MGI Ref ID J:103058]

Cheng C; Tempel D; van Haperen R; de Boer HC; Segers D; Huisman M; van Zonneveld AJ; Leenen PJ; van der Steen A; Serruys PW; de Crom R; Krams R. 2007. Shear stress-induced changes in atherosclerotic plaque composition are modulated by chemokines. J Clin Invest 117(3):616-26. [PubMed: 17304353]  [MGI Ref ID J:120778]

Chereshnev I; Trogan E; Omerhodzic S; Itskovich V; Aguinaldo JG; Fayad ZA; Fisher EA; Reis ED. 2003. Mouse model of heterotopic aortic arch transplantation. J Surg Res 111(2):171-6. [PubMed: 12850459]  [MGI Ref ID J:118962]

Choi J; Forster MJ; McDonald SR; Weintraub ST; Carroll CA; Gracy RW. 2004. Proteomic identification of specific oxidized proteins in ApoE-knockout mice: relevance to Alzheimer's disease. Free Radic Biol Med 36(9):1155-62. [PubMed: 15082069]  [MGI Ref ID J:91069]

Choy K; Beck K; Png FY; Wu BJ; Leichtweis SB; Thomas SR; Hou JY; Croft KD; Mori TA; Stocker R. 2005. Processes involved in the site-specific effect of probucol on atherosclerosis in apolipoprotein E gene knockout mice. Arterioscler Thromb Vasc Biol 25(8):1684-90. [PubMed: 15961704]  [MGI Ref ID J:114329]

Christman MA nd; Goetz DJ; Dickerson E; McCall KD; Lewis CJ; Benencia F; Silver MJ; Kohn LD; Malgor R. 2008. Wnt5a is expressed in murine and human atherosclerotic lesions. Am J Physiol Heart Circ Physiol 294(6):H2864-70. [PubMed: 18456733]  [MGI Ref ID J:136708]

Chu A; Ordonez ET; Hellerstein MK. 2006. Measurement of mouse vascular smooth muscle and atheroma cell proliferation by 2H2O incorporation into DNA. Am J Physiol Cell Physiol 291(5):C1014-21. [PubMed: 16774990]  [MGI Ref ID J:119869]

Chuah MI; Getchell ML. 1999. Metallothionein in olfactory mucosa of Alzheimer's disease patients and apoE-deficient mice. Neuroreport 10(9):1919-24. [PubMed: 10501533]  [MGI Ref ID J:59464]

Claudel T; Leibowitz MD; Fievet C; Tailleux A; Wagner B; Repa JJ; Torpier G; Lobaccaro JM; Paterniti JR; Mangelsdorf DJ; Heyman RA; Auwerx J. 2001. Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor. Proc Natl Acad Sci U S A 98(5):2610-5. [PubMed: 11226287]  [MGI Ref ID J:67869]

Clee SM; Bissada N; Miao F; Miao L; Marais AD; Henderson HE; Steures P; McManus J; McManus B; LeBoeuf RC; Kastelein JJ; Hayden MR. 2000. Plasma and vessel wall lipoprotein lipase have different roles in atherosclerosis J Lipid Res 41(4):521-31. [PubMed: 10744772]  [MGI Ref ID J:61561]

Collins RG; Velji R; Guevara NV; Hicks MJ; Chan L; Beaudet AL. 2000. P-Selectin or intercellular adhesion molecule (ICAM)-1 deficiency substantially protects against atherosclerosis in apolipoprotein E-deficient mice. J Exp Med 191(1):189-94. [PubMed: 10620617]  [MGI Ref ID J:59249]

Combadiere C; Potteaux S; Gao JL; Esposito B; Casanova S; Lee EJ; Debre P; Tedgui A; Murphy PM; Mallat Z. 2003. Decreased atherosclerotic lesion formation in CX3CR1/apolipoprotein E double knockout mice. Circulation 107(7):1009-16. [PubMed: 12600915]  [MGI Ref ID J:103047]

Conde-Knape K; Bensadoun A; Sobel JH; Cohn JS; Shachter NS. 2002. Overexpression of apoC-I in apoE-null mice: severe hypertriglyceridemia due to inhibition of hepatic lipase. J Lipid Res 43(12):2136-45. [PubMed: 12454276]  [MGI Ref ID J:80689]

Corey LM; Baker C; Luchtel DL. 2006. Heart-rate variability in the apolipoprotein E knockout transgenic mouse following exposure to Seattle particulate matter. J Toxicol Environ Health A 69(10):953-65. [PubMed: 16728373]  [MGI Ref ID J:136496]

Cozen AE; Moriwaki H; Kremen M; DeYoung MB; Dichek HL; Slezicki KI; Young SG; Veniant M; Dichek DA. 2004. Macrophage-targeted overexpression of urokinase causes accelerated atherosclerosis, coronary artery occlusions, and premature death. Circulation 109(17):2129-35. [PubMed: 15096455]  [MGI Ref ID J:102208]

Crauwels HM; Van Hove CE; Holvoet P; Herman AG; Bult H. 2003. Plaque-associated endothelial dysfunction in apolipoprotein E-deficient mice on a regular diet. Effect of human apolipoprotein AI. Cardiovasc Res 59(1):189-99. [PubMed: 12829190]  [MGI Ref ID J:132535]

Crisby M; Rahman SM; Sylven C; Winblad B; Schultzberg M. 2004. Effects of high cholesterol diet on gliosis in apolipoprotein E knockout mice. Implications for Alzheimer's disease and stroke. Neurosci Lett 369(2):87-92. [PubMed: 15450674]  [MGI Ref ID J:107524]

Cuff CA; Kothapalli D; Azonobi I; Chun S; Zhang Y; Belkin R; Yeh C; Secreto A; Assoian RK; Rader DJ; Pure E. 2001. The adhesion receptor CD44 promotes atherosclerosis by mediating inflammatory cell recruitment and vascular cell activation. J Clin Invest 108(7):1031-40. [PubMed: 11581304]  [MGI Ref ID J:72315]

Curfs DM; Lutgens E; Gijbels MJ; Kockx MM; Daemen MJ; van Schooten FJ. 2004. Chronic exposure to the carcinogenic compound benzo[a]pyrene induces larger and phenotypically different atherosclerotic plaques in ApoE-knockout mice. Am J Pathol 164(1):101-8. [PubMed: 14695324]  [MGI Ref ID J:88500]

Cyrus T; Pratico D; Zhao L; Witztum JL; Rader DJ; Rokach J; FitzGerald GA; Funk CD. 2001. Absence of 12/15-lipoxygenase expression decreases lipid peroxidation and atherogenesis in apolipoprotein e-deficient mice. Circulation 103(18):2277-82. [PubMed: 11342477]  [MGI Ref ID J:103392]

Cyrus T; Witztum JL; Rader DJ; Tangirala R; Fazio S; Linton MF; Funk CD. 1999. Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice [see comments] J Clin Invest 103(11):1597-604. [PubMed: 10359569]  [MGI Ref ID J:55714]

Czapiga M; Colton CA. 2003. Microglial function in human APOE3 and APOE4 transgenic mice: altered arginine transport. J Neuroimmunol 134(1-2):44-51. [PubMed: 12507771]  [MGI Ref ID J:105895]

Dai J; Li W; Chang L; Zhang Z; Tang C; Wang N; Zhu Y; Wang X. 2006. Role of redox factor-1 in hyperhomocysteinemia-accelerated atherosclerosis. Free Radic Biol Med 41(10):1566-77. [PubMed: 17045925]  [MGI Ref ID J:114515]

Dansky HM; Charlton SA; Barlow CB; Tamminen M; Smith JD; Frank JS; Breslow JL. 1999. Apo A-I inhibits foam cell formation in Apo E-deficient mice after monocyte adherence to endothelium. J Clin Invest 104(1):31-9. [PubMed: 10393696]  [MGI Ref ID J:115306]

Dansky HM; Charlton SA; Sikes JL; Heath SC; Simantov R; Levin LF; Shu P; Moore KJ; Breslow JL; Smith JD. 1999. Genetic background determines the extent of atherosclerosis in ApoE-deficient mice. Arterioscler Thromb Vasc Biol 19(8):1960-8. [PubMed: 10446078]  [MGI Ref ID J:57355]

Daugherty A; Manning MW; Cassis LA. 2000. Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice. J Clin Invest 105(11):1605-12. [PubMed: 10841519]  [MGI Ref ID J:112053]

Daugherty A; Pure E; Delfel-Butteiger D; Chen S; Leferovich J ; Roselaar SE ; Rader DJ. 1997. The effects of total lymphocyte deficiency on the extent of atherosclerosis in apolipoprotein E-/- mice. J Clin Invest 100(6):1575-80. [PubMed: 9294126]  [MGI Ref ID J:43047]

Davenport P; Tipping PG. 2003. The role of interleukin-4 and interleukin-12 in the progression of atherosclerosis in apolipoprotein E-deficient mice. Am J Pathol 163(3):1117-25. [PubMed: 12937153]  [MGI Ref ID J:85172]

Davis HR Jr; Hoos LM; Tetzloff G; Maguire M; Zhu LJ; Graziano MP; Altmann SW. 2007. Deficiency of Niemann-Pick C1 Like 1 prevents atherosclerosis in ApoE-/- mice. Arterioscler Thromb Vasc Biol 27(4):841-9. [PubMed: 17218600]  [MGI Ref ID J:135062]

Dawson TC; Kuziel WA; Osahar TA; Maeda N. 1999. Absence of CC chemokine receptor-2 reduces atherosclerosis in apolipoprotein E-deficient mice. Atherosclerosis 143(1):205-11. [PubMed: 10208497]  [MGI Ref ID J:84393]

De Sarno P; Jope RS. 1998. Phosphoinositide hydrolysis activated by muscarinic or glutamatergic, but not adrenergic, receptors is impaired in ApoE-deficient mice and by hydrogen peroxide and peroxynitrite. Exp Neurol 152(1):123-8. [PubMed: 9682019]  [MGI Ref ID J:106374]

DeMattos RB; Cirrito JR; Parsadanian M; May PC; O'Dell MA; Taylor JW; Harmony JA; Aronow BJ; Bales KR; Paul SM; Holtzman DM. 2004. ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo. Neuron 41(2):193-202. [PubMed: 14741101]  [MGI Ref ID J:107702]

Deeb RS; Shen H; Gamss C; Gavrilova T; Summers BD; Kraemer R; Hao G; Gross SS; Laine M; Maeda N; Hajjar DP; Upmacis RK. 2006. Inducible nitric oxide synthase mediates prostaglandin h2 synthase nitration and suppresses eicosanoid production. Am J Pathol 168(1):349-62. [PubMed: 16400036]  [MGI Ref ID J:104432]

Deguchi JO; Aikawa E; Libby P; Vachon JR; Inada M; Krane SM; Whittaker P; Aikawa M. 2005. Matrix metalloproteinase-13/collagenase-3 deletion promotes collagen accumulation and organization in mouse atherosclerotic plaques. Circulation 112(17):2708-15. [PubMed: 16230484]  [MGI Ref ID J:116828]

Deguchi JO; Aikawa M; Tung CH; Aikawa E; Kim DE; Ntziachristos V; Weissleder R; Libby P. 2006. Inflammation in atherosclerosis: visualizing matrix metalloproteinase action in macrophages in vivo. Circulation 114(1):55-62. [PubMed: 16801460]  [MGI Ref ID J:122883]

Dekker RJ; van Thienen JV; Rohlena J; de Jager SC; Elderkamp YW; Seppen J; de Vries CJ; Biessen EA; van Berkel TJ; Pannekoek H; Horrevoets AJ. 2005. Endothelial KLF2 Links Local Arterial Shear Stress Levels to the Expression of Vascular Tone-Regulating Genes. Am J Pathol 167(2):609-18. [PubMed: 16049344]  [MGI Ref ID J:99941]

Desurmont C; Caillaud JM; Emmanuel F; Benoit P; Fruchart JC; Castro G; Branellec D; Heard JM; Duverger N. 2000. Complete atherosclerosis regression after human ApoE gene transfer in ApoE-Deficient/Nude mice Arterioscler Thromb Vasc Biol 20(2):435-42. [PubMed: 10669641]  [MGI Ref ID J:60479]

Detmers PA; Hernandez M; Mudgett J; Hassing H; Burton C; Mundt S; Chun S; Fletcher D; Card DJ; Lisnock J; Weikel R; Bergstrom JD; Shevell DE; Hermanowski-Vosatka A; Sparrow CP; Chao YS; Rader DJ; Wright SD; Pure E. 2000. Deficiency in inducible nitric oxide synthase results in reduced atherosclerosis in apolipoprotein E-deficient mice J Immunol 165(6):3430-5. [PubMed: 10975863]  [MGI Ref ID J:64566]

Dever GJ; Benson R; Wainwright CL; Kennedy S; Spickett CM. 2008. Phospholipid chlorohydrin induces leukocyte adhesion to ApoE(-/-) mouse arteries via upregulation of P-selectin. Free Radic Biol Med 44(3):452-63. [PubMed: 18005671]  [MGI Ref ID J:130122]

Diez-Juan A; Andres V. 2001. The growth suppressor p27(Kip1) protects against diet-induced atherosclerosis. FASEB J 15(11):1989-95. [PubMed: 11532979]  [MGI Ref ID J:120150]

Dimayuga PC; Zhao X; Yano J; Chyu KY. 2006. Changes in immune responses to oxidized LDL epitopes during aging in hypercholesterolemic apoE(-/-) mice. Am J Physiol Regul Integr Comp Physiol 291(6):R1644-50. [PubMed: 16825416]  [MGI Ref ID J:115800]

Dithmar S; Curcio CA; Le NA; Brown S; Grossniklaus HE. 2000. Ultrastructural changes in Bruch's membrane of apolipoprotein E-deficient mice. Invest Ophthalmol Vis Sci 41(8):2035-42. [PubMed: 10892840]  [MGI Ref ID J:63155]

Ditiatkovski M; Toh BH; Bobik A. 2006. GM-CSF deficiency reduces macrophage PPAR-gamma expression and aggravates atherosclerosis in ApoE-deficient mice. Arterioscler Thromb Vasc Biol 26(10):2337-44. [PubMed: 16873730]  [MGI Ref ID J:128049]

Dodart JC; Bales KR; Johnstone EM; Little SP; Paul SM. 2002. Apolipoprotein E alters the processing of the beta-amyloid precursor protein in APP(V717F) transgenic mice. Brain Res 955(1-2):191-9. [PubMed: 12419536]  [MGI Ref ID J:80485]

Dodart JC; Mathis C; Bales KR; Paul SM; Ungerer A. 2000. Behavioral deficits in APP(V717F) transgenic mice deficient for the apolipoprotein E gene Neuroreport 11(3):603-7. [PubMed: 10718322]  [MGI Ref ID J:61265]

Dolev I; Michaelson DM. 2004. A nontransgenic mouse model shows inducible amyloid-beta (Abeta) peptide deposition and elucidates the role of apolipoprotein E in the amyloid cascade. Proc Natl Acad Sci U S A 101(38):13909-14. [PubMed: 15365176]  [MGI Ref ID J:92619]

Doorenbos C; Tsaih SW; Sheehan S; Ishimori N; Navis G; Churchill G; Dipetrillo K; Korstanje R. 2008. Quantitative Trait Loci for Urinary Albumin in Crosses Between C57BL/6J and A/J Inbred Mice in the Presence and Absence of Apoe. Genetics 179(1):693-9. [PubMed: 18493081]  [MGI Ref ID J:135073]

Drosatos K; Sanoudou D; Kypreos KE; Kardassis D; Zannis VI. 2007. A dominant negative form of the transcription factor c-Jun affects genes that have opposing effects on lipid homeostasis in mice. J Biol Chem 282(27):19556-64. [PubMed: 17456467]  [MGI Ref ID J:123576]

Dworschak M; d'Uscio LV; Breukelmann D; Hannon JD. 2005. Increased tolerance to hypoxic metabolic inhibition and reoxygenation of cardiomyocytes from apolipoprotein E-deficient mice. Am J Physiol Heart Circ Physiol 289(1):H160-7. [PubMed: 15734885]  [MGI Ref ID J:99888]

Eitzman DT; Westrick RJ; Shen Y; Bodary PF; Gu S; Manning SL; Dobies SL; Ginsburg D. 2005. Homozygosity for factor V Leiden leads to enhanced thrombosis and atherosclerosis in mice. Circulation 111(14):1822-5. [PubMed: 15809370]  [MGI Ref ID J:109686]

Eitzman DT; Westrick RJ; Xu Z; Tyson J; Ginsburg D. 2000. Plasminogen activator inhibitor-1 deficiency protects against atherosclerosis progression in the mouse carotid artery. Blood 96(13):4212-5. [PubMed: 11110693]  [MGI Ref ID J:106740]

Elhage R; Arnal JF; Pieraggi MT; Duverger N; Fievet C; Faye JC; Bayard F. 1997. 17 beta-estradiol prevents fatty streak formation in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 17(11):2679-84. [PubMed: 9409242]  [MGI Ref ID J:81001]

Elhage R; Clamens S; Reardon-Alulis C; Getz GS; Fievet C; Maret A; Arnal JF; Bayard F. 2000. Loss of atheroprotective effect of estradiol in immunodeficient mice. Endocrinology 141(1):462-5. [PubMed: 10614672]  [MGI Ref ID J:59156]

Elhage R; Gourdy P; Brouchet L; Jawien J; Fouque MJ; Fievet C; Huc X; Barreira Y; Couloumiers JC; Arnal JF; Bayard F. 2004. Deleting TCR alpha beta+ or CD4+ T lymphocytes leads to opposite effects on site-specific atherosclerosis in female apolipoprotein E-deficient mice. Am J Pathol 165(6):2013-8. [PubMed: 15579444]  [MGI Ref ID J:94976]

Elhage R; Gourdy P; Jawien J; Brouchet L; Castano C; Fievet C; Hansson GK; Arnal JF; Bayard F. 2005. The Atheroprotective Effect of 17{beta}-Estradiol Depends on Complex Interactions in Adaptive Immunity. Am J Pathol 167(1):267-74. [PubMed: 15972970]  [MGI Ref ID J:99377]

Elhage R; Jawien J; Rudling M; Ljunggren HG; Takeda K; Akira S; Bayard F; Hansson GK. 2003. Reduced atherosclerosis in interleukin-18 deficient apolipoprotein E-knockout mice. Cardiovasc Res 59(1):234-40. [PubMed: 12829194]  [MGI Ref ID J:102800]

Engel D; Dobrindt U; Tittel A; Peters P; Maurer J; Gutgemann I; Kaissling B; Kuziel W; Jung S; Kurts C. 2006. Tumor necrosis factor alpha- and inducible nitric oxide synthase-producing dendritic cells are rapidly recruited to the bladder in urinary tract infection but are dispensable for bacterial clearance. Infect Immun 74(11):6100-7. [PubMed: 16966414]  [MGI Ref ID J:113552]

Everett AW; Ernst EJ. 2004. Increased quantal size in transmission at slow but not fast neuromuscular synapses of apolipoprotein E deficient mice. Exp Neurol 185(2):290-6. [PubMed: 14736510]  [MGI Ref ID J:87833]

Ezra Y; Oron L; Moskovich L; Roses AD; Beni SM; Shohami E; Michaelson DM. 2003. Apolipoprotein E4 decreases whereas apolipoprotein E3 increases the level of secreted amyloid precursor protein after closed head injury. Neuroscience 121(2):315-25. [PubMed: 14521991]  [MGI Ref ID J:132283]

Fagan AM; Holtzman DM; Munson G; Mathur T; Schneider D; Chang LK; Getz GS; Reardon CA; Lukens J; Shah JA; LaDu MJ. 1999. Unique lipoproteins secreted by primary astrocytes from wild type, apoE (-/-), and human apoE transgenic mice. J Biol Chem 274(42):30001-7. [PubMed: 10514484]  [MGI Ref ID J:58019]

Fagan AM; Murphy BA; Patel SN; Kilbridge JF; Mobley WC; Bu G; Holtzman DM. 1998. Evidence for normal aging of the septo-hippocampal cholinergic system in apoE (-/-) mice but impaired clearance of axonal degeneration products following injury. Exp Neurol 151(2):314-25. [PubMed: 9628766]  [MGI Ref ID J:48287]

Fagan AM; Watson M; Parsadanian M; Bales KR; Paul SM; Holtzman DM. 2002. Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease. Neurobiol Dis 9(3):305-18. [PubMed: 11950276]  [MGI Ref ID J:127846]

Fan D; Yancey PG; Qiu S; Ding L; Weeber EJ; Linton MF; Fazio S. 2008. Self-association of human PCSK9 correlates with its LDLR-degrading activity. Biochemistry 47(6):1631-9. [PubMed: 18197702]  [MGI Ref ID J:132491]

Fan YY; Ramos KS; Chapkin RS. 2001. Dietary gamma-linolenic acid suppresses aortic smooth muscle cell proliferation and modifies atherosclerotic lesions in apolipoprotein E knockout mice. J Nutr 131(6):1675-81. [PubMed: 11385052]  [MGI Ref ID J:69821]

Farese RVJr; Veniant MM; Cham CM; Flynn LM; Pierotti V; Loring JF; Traber M; Ruland S; Stokowski RS; Huszar D; Young SG. 1996. Phenotypic analysis of mice expressing exclusively apolipoprotein B48 or apolipoprotein B100. Proc Natl Acad Sci U S A 93(13):6393-8. [PubMed: 8692825]  [MGI Ref ID J:33830]

Fazio S; Babaev VR; Burleigh ME; Major AS; Hasty AH; Linton MF. 2002. Physiological expression of macrophage apoE in the artery wall reduces atherosclerosis in severely hyperlipidemic mice. J Lipid Res 43(10):1602-9. [PubMed: 12364544]  [MGI Ref ID J:79439]

Febbraio M; Podrez EA; Smith JD; Hajjar DP; Hazen SL; Hoff HF; Sharma K; Silverstein RL. 2000. Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice [see comments] J Clin Invest 105(8):1049-56. [PubMed: 10772649]  [MGI Ref ID J:61672]

Feng X; Li H; Rumbin AA; Wang X; La Cava A; Brechtelsbauer K; Castellani LW; Witztum JL; Lusis AJ; Tsao BP. 2007. ApoE-/-Fas-/- C57BL/6 mice: a novel murine model simultaneously exhibits lupus nephritis, atherosclerosis, and osteopenia. J Lipid Res 48(4):794-805. [PubMed: 17259598]  [MGI Ref ID J:121671]

Fernandez-Hernando C; Ackah E; Yu J; Suarez Y; Murata T; Iwakiri Y; Prendergast J; Miao RQ; Birnbaum MJ; Sessa WC. 2007. Loss of akt1 leads to severe atherosclerosis and occlusive coronary artery disease. Cell Metab 6(6):446-57. [PubMed: 18054314]  [MGI Ref ID J:130443]

Forte TM; Subbanagounder G; Berliner JA; Blanche PJ; Clermont AO; Jia Z; Oda MN; Krauss RM; Bielicki JK. 2002. Altered activities of anti-atherogenic enzymes LCAT, paraoxonase, and platelet-activating factor acetylhydrolase in atherosclerosis-susceptible mice. J Lipid Res 43(3):477-85. [PubMed: 11893784]  [MGI Ref ID J:75568]

Frank PG; Lee H; Park DS; Tandon NN; Scherer PE; Lisanti MP. 2004. Genetic ablation of caveolin-1 confers protection against atherosclerosis. Arterioscler Thromb Vasc Biol 24(1):98-105. [PubMed: 14563650]  [MGI Ref ID J:101788]

Friedrich EB; Clever YP; Wassmann S; Werner N; Bohm M; Nickenig G. 2006. Role of integrin-linked kinase in vascular smooth muscle cells: regulation by statins and angiotensin II. Biochem Biophys Res Commun 349(3):883-9. [PubMed: 16962068]  [MGI Ref ID J:113091]

Fryer JD; Simmons K; Parsadanian M; Bales KR; Paul SM; Sullivan PM; Holtzman DM. 2005. Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model. J Neurosci 25(11):2803-10. [PubMed: 15772340]  [MGI Ref ID J:98636]

Fryer JD; Taylor JW; DeMattos RB; Bales KR; Paul SM; Parsadanian M; Holtzman DM. 2003. Apolipoprotein E markedly facilitates age-dependent cerebral amyloid angiopathy and spontaneous hemorrhage in amyloid precursor protein transgenic mice. J Neurosci 23(21):7889-96. [PubMed: 12944519]  [MGI Ref ID J:85307]

Fu T; Borensztajn J. 2006. Simvastatin causes the formation of cholesterol-rich remnants in mice lacking apoE. Biochem Biophys Res Commun 341(4):1172-6. [PubMed: 16460674]  [MGI Ref ID J:105757]

Fu T; Kozarsky KF; Borensztajn J. 2003. Overexpression of SR-BI by adenoviral vector reverses the fibrateinduced hypercholesterolemia of apolipoprotein E-deficient mice. J Biol Chem 278(52):52559-63. [PubMed: 14570884]  [MGI Ref ID J:87086]

Fullerton SM; Shirman GA; Strittmatter WJ; Matthew WD. 2001. Impairment of the blood-nerve and blood-brain barriers in apolipoprotein e knockout mice. Exp Neurol 169(1):13-22. [PubMed: 11312553]  [MGI Ref ID J:69455]

Fullerton SM; Strittmatter WJ; Matthew WD. 1998. Peripheral sensory nerve defects in apolipoprotein E knockout mice. Exp Neurol 153(1):156-63. [PubMed: 9743578]  [MGI Ref ID J:106368]

Furbee JW Jr; Francone O; Parks JS. 2002. In vivo contribution of LCAT to apolipoprotein B lipoprotein cholesteryl esters in LDL receptor and apolipoprotein E knockout mice. J Lipid Res 43(3):428-37. [PubMed: 11893779]  [MGI Ref ID J:75567]

Furbee JW Jr; Sawyer JK; Parks JS. 2002. Lecithin:cholesterol acyltransferase deficiency increases atherosclerosis in the low density lipoprotein receptor and apolipoprotein E knockout mice. J Biol Chem 277(5):3511-9. [PubMed: 11719520]  [MGI Ref ID J:74315]

Galkina E; Kadl A; Sanders J; Varughese D; Sarembock IJ; Ley K. 2006. Lymphocyte recruitment into the aortic wall before and during development of atherosclerosis is partially L-selectin dependent. J Exp Med 203(5):1273-82. [PubMed: 16682495]  [MGI Ref ID J:124135]

Gallardo G; Schluter OM; Sudhof TC. 2008. A molecular pathway of neurodegeneration linking alpha-synuclein to ApoE and Abeta peptides. Nat Neurosci 11(3):301-8. [PubMed: 18297066]  [MGI Ref ID J:131733]

Gao J; Katagiri H; Ishigaki Y; Yamada T; Ogihara T; Imai J; Uno K; Hasegawa Y; Kanzaki M; Yamamoto TT; Ishibashi S; Oka Y. 2007. Involvement of apolipoprotein E in excess fat accumulation and insulin resistance. Diabetes 56(1):24-33. [PubMed: 17192461]  [MGI Ref ID J:121950]

Gates AC; Bernal-Mizrachi C; Chinault SL; Feng C; Schneider JG; Coleman T; Malone JP; Townsend RR; Chakravarthy MV; Semenkovich CF. 2007. Respiratory uncoupling in skeletal muscle delays death and diminishes age-related disease. Cell Metab 6(6):497-505. [PubMed: 18054318]  [MGI Ref ID J:130440]

Gavrila D; Li WG; McCormick ML; Thomas M; Daugherty A; Cassis LA; Miller FJ Jr; Oberley LW; Dellsperger KC; Weintraub NL. 2005. Vitamin E inhibits abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 25(8):1671-7. [PubMed: 15933246]  [MGI Ref ID J:114336]

Georgopoulos S; McKee A; Kan HY; Zannis VI. 2002. Generation and characterization of two transgenic mouse lines expressing human ApoE2 in neurons and glial cells. Biochemistry 41(30):9293-301. [PubMed: 12135350]  [MGI Ref ID J:78003]

Ghazalpour A; Doss S; Zhang B; Wang S; Plaisier C; Castellanos R; Brozell A; Schadt EE; Drake TA; Lusis AJ; Horvath S. 2006. Integrating genetic and network analysis to characterize genes related to mouse weight. PLoS Genet 2(8):e130. [PubMed: 16934000]  [MGI Ref ID J:115983]

Glaros EN; Kim WS; Quinn CM; Jessup W; Rye KA; Garner B. 2008. Myriocin slows the progression of established atherosclerotic lesions in apolipoprotein E gene knockout mice. J Lipid Res 49(2):324-31. [PubMed: 17978313]  [MGI Ref ID J:131877]

Godschalk RW; Albrecht C; Curfs DM; Schins RP; Bartsch H; van Schooten FJ; Nair J. 2007. Decreased levels of lipid peroxidation-induced DNA damage in the onset of atherogenesis in apolipoprotein E deficient mice. Mutat Res 621(1-2):87-94. [PubMed: 17418875]  [MGI Ref ID J:123175]

Goldstein LB; Vitek MP; Dawson H; Bullman S. 2000. Expression of the apolipoprotein E gene does not affect motor recovery after sensorimotor cortex injury in the mouse. Neuroscience 99(4):705-10. [PubMed: 10974433]  [MGI Ref ID J:119167]

Gonzalez-Navarro H; Nong Z; Amar MJ; Shamburek RD; Najib-Fruchart J; Paigen BJ; Brewer HB Jr; Santamarina-Fojo S. 2004. The ligand-binding function of hepatic lipase modulates the development of atherosclerosis in transgenic mice. J Biol Chem 279(44):45312-21. [PubMed: 15304509]  [MGI Ref ID J:94495]

Goodrum JF; Bouldin TW; Zhang SH; Maeda N; Popko B. 1995. Nerve regeneration and cholesterol reutilization occur in the absence of apolipoproteins E and A-I in mice. J Neurochem 64(1):408-16. [PubMed: 7798939]  [MGI Ref ID J:22362]

Gough PJ; Gomez IG; Wille PT; Raines EW. 2006. Macrophage expression of active MMP-9 induces acute plaque disruption in apoE-deficient mice. J Clin Invest 116(1):59-69. [PubMed: 16374516]  [MGI Ref ID J:105266]

Gourdy P; Schambourg A; Filipe C; Douin-Echinard V; Garmy-Susini B; Calippe B; Terce F; Bayard F; Arnal JF. 2007. Transforming growth factor activity is a key determinant for the effect of estradiol on fatty streak deposit in hypercholesterolemic mice. Arterioscler Thromb Vasc Biol 27(10):2214-21. [PubMed: 17690314]  [MGI Ref ID J:134877]

Grainger DJ; Reckless J; McKilligin E. 2004. Apolipoprotein E modulates clearance of apoptotic bodies in vitro and in vivo, resulting in a systemic proinflammatory state in apolipoprotein E-deficient mice. J Immunol 173(10):6366-75. [PubMed: 15528376]  [MGI Ref ID J:94282]

Grootendorst J; Bour A; Vogel E; Kelche C; Sullivan PM; Dodart JC; Bales K; Mathis C. 2005. Human apoE targeted replacement mouse lines: h-apoE4 and h-apoE3 mice differ on spatial memory performance and avoidance behavior. Behav Brain Res 159(1):1-14. [PubMed: 15794991]  [MGI Ref ID J:97643]

Gross S; Tilly P; Hentsch D; Vonesch JL; Fabre JE. 2007. Vascular wall-produced prostaglandin E2 exacerbates arterial thrombosis and atherothrombosis through platelet EP3 receptors. J Exp Med 204(2):311-20. [PubMed: 17242161]  [MGI Ref ID J:125376]

Guo GL; Santamarina-Fojo S; Akiyama TE; Amar MJ; Paigen BJ; Brewer B Jr; Gonzalez FJ. 2006. Effects of FXR in foam-cell formation and atherosclerosis development. Biochim Biophys Acta 1761(12):1401-9. [PubMed: 17110163]  [MGI Ref ID J:118172]

Guo Y; Zhang C; Du X; Nair U; Yoo TJ. 2005. Morphological and functional alterations of the cochlea in apolipoprotein E gene deficient mice. Hear Res 208(1-2):54-67. [PubMed: 16051453]  [MGI Ref ID J:101576]

Guo Z; Mitchell-Raymundo F; Yang H; Ikeno Y; Nelson J; Diaz V; Richardson A; Reddick R. 2002. Dietary restriction reduces atherosclerosis and oxidative stress in the aorta of apolipoprotein E-deficient mice. Mech Ageing Dev 123(8):1121-31. [PubMed: 12044962]  [MGI Ref ID J:76930]

Guo Z; Ran Q; Roberts LJ nd; Zhou L; Richardson A; Sharan C; Wu D; Yang H. 2008. Suppression of atherogenesis by overexpression of glutathione peroxidase-4 in apolipoprotein E-deficient mice. Free Radic Biol Med 44(3):343-52. [PubMed: 18215741]  [MGI Ref ID J:130157]

Hafezi-Moghadam A; Thomas KL; Wagner DD. 2007. ApoE deficiency leads to a progressive age-dependent blood-brain barrier leakage. Am J Physiol Cell Physiol 292(4):C1256-62. [PubMed: 16870825]  [MGI Ref ID J:125887]

Haghighat A; Weiss D; Whalin MK; Cowan DP; Taylor WR. 2007. Granulocyte colony-stimulating factor and granulocyte macrophage colony-stimulating factor exacerbate atherosclerosis in apolipoprotein E-deficient mice. Circulation 115(15):2049-54. [PubMed: 17404156]  [MGI Ref ID J:135370]

Han SH; Chung SY. 2000. Marked hippocampal neuronal damage without motor deficits after mild concussive-like brain injury in apolipoprotein E-deficient mice Ann N Y Acad Sci 903:357-65. [PubMed: 10818526]  [MGI Ref ID J:62422]

Han X; Cheng H; Fryer JD; Fagan AM; Holtzman DM. 2003. Novel role for apolipoprotein E in the central nervous system. Modulation of sulfatide content. J Biol Chem 278(10):8043-51. [PubMed: 12501252]  [MGI Ref ID J:131491]

Han X; Holtzman DM; McKeel DW Jr. 2001. Plasmalogen deficiency in early Alzheimer's disease subjects and in animal models: molecular characterization using electrospray ionization mass spectrometry. J Neurochem 77(4):1168-80. [PubMed: 11359882]  [MGI Ref ID J:69528]

Hanniman EA; Lambert G; McCarthy TC; Sinal CJ. 2005. Loss of functional farnesoid X receptor increases atherosclerotic lesions in apolipoprotein E-deficient mice. J Lipid Res 46(12):2595-604. [PubMed: 16186601]  [MGI Ref ID J:106149]

Hansmann G; Wagner RA; Schellong S; Perez VA; Urashima T; Wang L; Sheikh AY; Suen RS; Stewart DJ; Rabinovitch M. 2007. Pulmonary arterial hypertension is linked to insulin resistance and reversed by peroxisome proliferator-activated receptor-gamma activation. Circulation 115(10):1275-84. [PubMed: 17339547]  [MGI Ref ID J:132327]

Hansmann G; de Jesus Perez VA; Alastalo TP; Alvira CM; Guignabert C; Bekker JM; Schellong S; Urashima T; Wang L; Morrell NW; Rabinovitch M. 2008. An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension. J Clin Invest 118(5):1846-57. [PubMed: 18382765]  [MGI Ref ID J:136168]

Hao M; Head WS; Gunawardana SC; Hasty AH; Piston DW. 2007. Direct effect of cholesterol on insulin secretion: a novel mechanism for pancreatic beta-cell dysfunction. Diabetes 56(9):2328-38. [PubMed: 17575085]  [MGI Ref ID J:126584]

Harja E; Bu DX; Hudson BI; Chang JS; Shen X; Hallam K; Kalea AZ; Lu Y; Rosario RH; Oruganti S; Nikolla Z; Belov D; Lalla E; Ramasamy R; Yan SF; Schmidt AM. 2008. Vascular and inflammatory stresses mediate atherosclerosis via RAGE and its ligands in apoE-/- mice. J Clin Invest 118(1):183-94. [PubMed: 18079965]  [MGI Ref ID J:130844]

Harja E; Bucciarelli LG; Lu Y; Stern DM; Zou YS; Schmidt AM; Yan SF. 2004. Early growth response-1 promotes atherogenesis: mice deficient in early growth response-1 and apolipoprotein E display decreased atherosclerosis and vascular inflammation. Circ Res 94(3):333-9. [PubMed: 14670837]  [MGI Ref ID J:96665]

Harrington SC; Simari RD; Conover CA. 2007. Genetic deletion of pregnancy-associated plasma protein-A is associated with resistance to atherosclerotic lesion development in apolipoprotein E-deficient mice challenged with a high-fat diet. Circ Res 100(12):1696-702. [PubMed: 17510462]  [MGI Ref ID J:137790]

Harris FM; Brecht WJ; Xu Q; Mahley RW; Huang Y. 2004. Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc. J Biol Chem 279(43):44795-801. [PubMed: 15322121]  [MGI Ref ID J:93984]

Hartley CJ; Reddy AK; Madala S; Martin-McNulty B; Vergona R; Sullivan ME; Halks-Miller M; Taffet GE; Michael LH; Entman ML; Wang YX. 2000. Hemodynamic changes in apolipoprotein E-knockout mice. Am J Physiol Heart Circ Physiol 279(5):H2326-34. [PubMed: 11045969]  [MGI Ref ID J:108154]

Hartman RE; Laurer H; Longhi L; Bales KR; Paul SM; McIntosh TK; Holtzman DM. 2002. Apolipoprotein E4 influences amyloid deposition but not cell loss after traumatic brain injury in a mouse model of Alzheimer's disease. J Neurosci 22(23):10083-7. [PubMed: 12451108]  [MGI Ref ID J:133058]

Hartman RE; Wozniak DF; Nardi A; Olney JW; Sartorius L; Holtzman DM. 2001. Behavioral phenotyping of GFAP-apoE3 and -apoE4 transgenic mice: apoE4 mice show profound working memory impairments in the absence of Alzheimer's-like neuropathology. Exp Neurol 170(2):326-44. [PubMed: 11476599]  [MGI Ref ID J:71062]

Hashimoto T; Kihara M; Imai N; Yoshida S; Shimoyamada H; Yasuzaki H; Ishida J; Toya Y; Kiuchi Y; Hirawa N; Tamura K; Yazawa T; Kitamura H; Fukamizu A; Umemura S. 2007. Requirement of apelin-apelin receptor system for oxidative stress-linked atherosclerosis. Am J Pathol 171(5):1705-12. [PubMed: 17884970]  [MGI Ref ID J:126802]

Hatcher JP; Virley D; Hadingham SJ; Roberts J; Hunter AJ; Parsons AA. 2002. The behavioural effect of middle cerebral artery occlusion on apolipoprotein-E deficient mice. Behav Brain Res 131(1-2):139-49. [PubMed: 11844581]  [MGI Ref ID J:96228]

Hemdahl AL; Falk E; Thoren P; Hansson GK. 2004. Thrombin inhibitor reduces myocardial infarction in apoE-/- x LDLR-/- mice. Am J Physiol Heart Circ Physiol 287(2):H872-7. [PubMed: 15031124]  [MGI Ref ID J:95598]

Hermanowski-Vosatka A; Balkovec JM; Cheng K; Chen HY; Hernandez M; Koo GC; Le Grand CB; Li Z; Metzger JM; Mundt SS; Noonan H; Nunes CN; Olson SH; Pikounis B; Ren N; Robertson N; Schaeffer JM; Shah K; Springer MS; Strack AM; Strowski M; Wu K; Wu T; Xiao J; Zhang BB; Wright SD; Thieringer R. 2005. 11beta-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice. J Exp Med 202(4):517-27. [PubMed: 16103409]  [MGI Ref ID J:100504]

Hernandez-Vargas P; Ortiz-Munoz G; Lopez-Franco O; Suzuki Y; Gallego-Delgado J; Sanjuan G; Lazaro A; Lopez-Parra V; Ortega L; Egido J; Gomez-Guerrero C. 2006. Fcgamma receptor deficiency confers protection against atherosclerosis in apolipoprotein E knockout mice. Circ Res 99(11):1188-96. [PubMed: 17053192]  [MGI Ref ID J:129087]

Hirasawa H; Tanaka S; Sakai A; Tsutsui M; Shimokawa H; Miyata H; Moriwaki S; Niida S; Ito M; Nakamura T. 2007. ApoE gene deficiency enhances the reduction of bone formation induced by a high-fat diet through the stimulation of p53-mediated apoptosis in osteoblastic cells. J Bone Miner Res 22(7):1020-30. [PubMed: 17388726]  [MGI Ref ID J:137540]

Hirsch-Reinshagen V; Zhou S; Burgess BL; Bernier L; McIsaac SA; Chan JY; Tansley GH; Cohn JS; Hayden MR; Wellington CL. 2004. Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain. J Biol Chem 279(39):41197-207. [PubMed: 15269218]  [MGI Ref ID J:93331]

Hirschfield GM; Gallimore JR; Kahan MC; Hutchinson WL; Sabin CA; Benson GM; Dhillon AP; Tennent GA; Pepys MB. 2005. Transgenic human C-reactive protein is not proatherogenic in apolipoprotein E-deficient mice. Proc Natl Acad Sci U S A 102(23):8309-14. [PubMed: 15919817]  [MGI Ref ID J:99730]

Hodgin JB; Knowles JW; Kim HS; Smithies O; Maeda N. 2002. Interactions between endothelial nitric oxide synthase and sex hormones in vascular protection in mice. J Clin Invest 109(4):541-8. [PubMed: 11854327]  [MGI Ref ID J:74702]

Hofmann MA; Lalla E; Lu Y; Gleason MR; Wolf BM; Tanji N; Ferran LJ Jr; Kohl B; Rao V; Kisiel W; Stern DM; Schmidt AM. 2001. Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model. J Clin Invest 107(6):675-83. [PubMed: 11254667]  [MGI Ref ID J:120549]

Hofmann SM; Perez-Tilve D; Greer TM; Coburn BA; Grant E; Basford JE; Tschop MH; Hui DY. 2008. Defective lipid delivery modulates glucose tolerance and metabolic response to diet in apolipoprotein E-deficient mice. Diabetes 57(1):5-12. [PubMed: 17914034]  [MGI Ref ID J:132417]

Holm TM; Braun A; Trigatti BL; Brugnara C; Sakamoto M; Krieger M; Andrews NC. 2002. Failure of red blood cell maturation in mice with defects in the high-density lipoprotein receptor SR-BI. Blood 99(5):1817-24. [PubMed: 11861300]  [MGI Ref ID J:75090]

Holtzman DM; Bales KR; Tenkova T; Fagan AM; Parsadanian M; Sartorius LJ; Mackey B; Olney J; McKeel D; Wozniak D; Paul SM. 2000. Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A 97(6):2892-7. [PubMed: 10694577]  [MGI Ref ID J:61176]

Holtzman DM; Bales KR; Wu S; Bhat P; Parsadanian M; Fagan AM; Chang LK; Sun Y; Paul SM. 1999. Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease. J Clin Invest 103(6):R15-R21. [PubMed: 10079115]  [MGI Ref ID J:53613]

Holtzman DM; Fagan AM; Mackey B; Tenkova T; Sartorius L; Paul SM; Bales K; Ashe KH; Irizarry MC; Hyman BT. 2000. Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model. Ann Neurol 47(6):739-47. [PubMed: 10852539]  [MGI Ref ID J:113061]

Holvoet P; Danloy S; Deridder E; Lox M; Bernar H; Dhoest A; Collen D. 1998. Substitution of the carboxyl-terminal domain of apo AI with apo AII sequences restores the potential of HDL to reduce the progression of atherosclerosis in apo E knockout mice. J Clin Invest 102(2):379-85. [PubMed: 9664079]  [MGI Ref ID J:115147]

Homeister JW; Daugherty A; Lowe JB. 2004. Alpha(1,3)fucosyltransferases FucT-IV and FucT-VII control susceptibility to atherosclerosis in apolipoprotein E-/- mice. Arterioscler Thromb Vasc Biol 24(10):1897-903. [PubMed: 15308551]  [MGI Ref ID J:102212]

Hopkins PC; Huang Y; McGuire JG; Pitas RE. 2002. Evidence for differential effects of apoE3 and apoE4 on HDL metabolism. J Lipid Res 43(11):1881-9. [PubMed: 12401887]  [MGI Ref ID J:123999]

Horsburgh K; Kelly S; McCulloch J; Higgins GA; Roses AD; Nicoll JA. 1999. Increased neuronal damage in apolipoprotein E-deficient mice following global ischaemia. Neuroreport 10(4):837-41. [PubMed: 10208557]  [MGI Ref ID J:54423]

Horsburgh K; McCulloch J; Nilsen M; Roses AD; Nicoll JA. 2000. Increased neuronal damage and apoE immunoreactivity in human apolipoprotein E, E4 isoform-specific, transgenic mice after global cerebral ischaemia. Eur J Neurosci 12(12):4309-17. [PubMed: 11122341]  [MGI Ref ID J:129722]

Hoshii Y; Kawano H; Cui D; Takeda T; Gondo T; Takahashi M; Kogishi K ; Higuchi K ; Ishihara T. 1997. Amyloid A protein amyloidosis induced in apolipoprotein-E-deficient mice. Am J Pathol 151(4):911-7. [PubMed: 9327723]  [MGI Ref ID J:43190]

Huang M; Pang X; Karalis K; Theoharides TC. 2003. Stress-induced interleukin-6 release in mice is mast cell-dependent and more pronounced in Apolipoprotein E knockout mice. Cardiovasc Res 59(1):241-9. [PubMed: 12829195]  [MGI Ref ID J:102798]

Huang Y; Liu XQ; Rall SC Jr; Taylor JM; von Eckardstein A; Assmann G; Mahley RW. 1998. Overexpression and accumulation of apolipoprotein E as a cause of hypertriglyceridemia. J Biol Chem 273(41):26388-93. [PubMed: 9756870]  [MGI Ref ID J:115206]

Huang Y; Rall SC Jr; Mahley RW. 1997. Genetic factors precipitating type III hyperlipoproteinemia in hypolipidemic transgenic mice expressing human apolipoprotein E2. Arterioscler Thromb Vasc Biol 17(11):2817-24. [PubMed: 9409260]  [MGI Ref ID J:45728]

Huang ZH; Reardon CA; Mazzone T. 2006. Endogenous ApoE expression modulates adipocyte triglyceride content and turnover. Diabetes 55(12):3394-402. [PubMed: 17130485]  [MGI Ref ID J:121013]

Huber SA; Sakkinen P; Conze D; Hardin N; Tracy R. 1999. Interleukin-6 exacerbates early atherosclerosis in mice. Arterioscler Thromb Vasc Biol 19(10):2364-7. [PubMed: 10521365]  [MGI Ref ID J:103386]

Hudson BI; Bucciarelli LG; Wendt T; Sakaguchi T; Lalla E; Qu W; Lu Y; Lee L; Stern DM; Naka Y; Ramasamy R; Yan SD; Yan SF; D'Agati V; Schmidt AM. 2003. Blockade of receptor for advanced glycation endproducts: a new target for therapeutic intervention in diabetic complications and inflammatory disorders. Arch Biochem Biophys 419(1):80-8. [PubMed: 14568011]  [MGI Ref ID J:86419]

Huo Y; Schober A; Forlow SB; Smith DF; Hyman MC; Jung S; Littman DR; Weber C; Ley K. 2003. Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E. Nat Med 9(1):61-7. [PubMed: 12483207]  [MGI Ref ID J:81164]

Igbavboa U; Avdulov NA; Chochina SV; Wood WG. 1997. Transbilayer distribution of cholesterol is modified in brain synaptic plasma membranes of knockout mice deficient in the low-density lipoprotein receptor, apolipoprotein E, or both proteins. J Neurochem 69(4):1661-7. [PubMed: 9326295]  [MGI Ref ID J:43043]

Ihara Y; Egashira K; Nakano K; Ohtani K; Kubo M; Koga J; Iwai M; Horiuchi M; Gang Z; Yamagishi S; Sunagawa K. 2007. Upregulation of the ligand-RAGE pathway via the angiotensin II type I receptor is essential in the pathogenesis of diabetic atherosclerosis. J Mol Cell Cardiol 43(4):455-64. [PubMed: 17761193]  [MGI Ref ID J:126372]

Imai Y; Shindo T; Maemura K; Sata M; Saito Y; Kurihara Y; Akishita M; Osuga J; Ishibashi S; Tobe K; Morita H; Oh-hashi Y; Suzuki T; Maekawa H; Kangawa K; Minamino N; Yazaki Y; Nagai R; Kurihara H. 2002. Resistance to neointimal hyperplasia and fatty streak formation in mice with adrenomedullin overexpression. Arterioscler Thromb Vasc Biol 22(8):1310-5. [PubMed: 12171793]  [MGI Ref ID J:103212]

Inoue K; Arai Y; Kurihara H; Kita T; Sawamura T. 2005. Overexpression of lectin-like oxidized low-density lipoprotein receptor-1 induces intramyocardial vasculopathy in apolipoprotein E-null mice. Circ Res 97(2):176-84. [PubMed: 15961718]  [MGI Ref ID J:111393]

Ishibashi S; Herz J; Maeda N; Goldstein JL; Brown MS. 1994. The two-receptor model of lipoprotein clearance: tests of the hypothesis in knockout mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins. Proc Natl Acad Sci U S A 91(10):4431-5. [PubMed: 8183926]  [MGI Ref ID J:18138]

Ishibashi S; Perrey S; Chen Z; Osuga Ji; Shimada M; Ohashi K; Harada K; Yazaki Y; Yamada N. 1996. Role of the low density lipoprotein (LDL) receptor pathway in the metabolism of chylomicron remnants. A quantitative study in knockout mice lacking the LDL receptor, apolipoprotein E, or both. J Biol Chem 271(37):22422-7. [PubMed: 8798405]  [MGI Ref ID J:35377]

Ishida T; Choi SY; Kundu RK; Spin J; Yamashita T; Hirata K; Kojima Y; Yokoyama M; Cooper AD; Quertermous T. 2004. Endothelial lipase modulates susceptibility to atherosclerosis in apolipoprotein-E-deficient mice. J Biol Chem 279(43):45085-92. [PubMed: 15304490]  [MGI Ref ID J:93987]

Ishigaki Y; Oikawa S; Suzuki T; Usui S; Magoori K; Kim DH; Suzuki H; Sasaki J; Sasano H; Okazaki M; Toyota T; Saito T; Yamamoto TT. 2000. Virus-mediated transduction of apolipoprotein E (ApoE)-sendai develops lipoprotein glomerulopathy in ApoE-deficient mice J Biol Chem 275(40):31269-73. [PubMed: 10903326]  [MGI Ref ID J:65016]

Ishimori N; Iwabuchi K; Fujii S; Watano K; Iwabuchi C; Ato M; Chiba H; Tanaka S; Kitabatake A; Onoe K. 2001. Mixed allogeneic chimerism with wild-type strains ameliorates atherosclerosis in apolipoprotein E-deficient mice. J Leukoc Biol 69(5):732-40. [PubMed: 11358981]  [MGI Ref ID J:69647]

Isoda K; Sawada S; Ishigami N; Matsuki T; Miyazaki K; Kusuhara M; Iwakura Y; Ohsuzu F. 2004. Lack of interleukin-1 receptor antagonist modulates plaque composition in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 24(6):1068-73. [PubMed: 15059807]  [MGI Ref ID J:102337]

Ivanovski O; Szumilak D; Nguyen-Khoa T; Ruellan N; Phan O; Lacour B; Descamps-Latscha B; Drueke TB; Massy ZA. 2005. The antioxidant N-acetylcysteine prevents accelerated atherosclerosis in uremic apolipoprotein E knockout mice. Kidney Int 67(6):2288-94. [PubMed: 15882270]  [MGI Ref ID J:110116]

Iwai M; Chen R; Li Z; Shiuchi T; Suzuki J; Ide A; Tsuda M; Okumura M; Min LJ; Mogi M; Horiuchi M. 2005. Deletion of angiotensin II type 2 receptor exaggerated atherosclerosis in apolipoprotein E-null mice. Circulation 112(11):1636-43. [PubMed: 16145000]  [MGI Ref ID J:116799]

Jawien J; Gajda M; Olszanecki R; Korbut R. 2007. BAY x 1005 attenuates atherosclerosis in apoE/LDLR - double knockout mice. J Physiol Pharmacol 58(3):583-8. [PubMed: 17928652]  [MGI Ref ID J:130080]

Ji Y; Gong Y; Gan W; Beach T; Holtzman DM; Wisniewski T. 2003. Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer's disease patients. Neuroscience 122(2):305-15. [PubMed: 14614898]  [MGI Ref ID J:126171]

Jiang XC; Beyer TP; Li Z; Liu J; Quan W; Schmidt RJ; Zhang Y; Bensch WR; Eacho PI; Cao G. 2003. Enlargement of high density lipoprotein in mice via liver X receptor activation requires apolipoprotein E and is abolished by cholesteryl ester transfer protein expression. J Biol Chem 278(49):49072-8. [PubMed: 12947111]  [MGI Ref ID J:86766]

Jiang XC; Tall AR; Qin S; Lin M; Schneider M; Lalanne F; Deckert V; Desrumaux C; Athias A; Witztum JL; Lagrost L. 2002. Phospholipid transfer protein deficiency protects circulating lipoproteins from oxidation due to the enhanced accumulation of vitamin E. J Biol Chem 277(35):31850-6. [PubMed: 12105225]  [MGI Ref ID J:120468]

Johansson ME; Hagg U; Wikstrom J; Wickman A; Bergstrom G; Gan LM. 2005. Haemodynamically significant plaque formation and regional endothelial dysfunction in cholesterol-fed ApoE-/- mice. Clin Sci (Lond) 108(6):531-8. [PubMed: 15675896]  [MGI Ref ID J:109794]

Joseph SB; McKilligin E; Pei L; Watson MA; Collins AR; Laffitte BA; Chen M; Noh G; Goodman J; Hagger GN; Tran J; Tippin TK; Wang X; Lusis AJ; Hsueh WA; Law RE; Collins JL; Willson TM; Tontonoz P. 2002. Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Proc Natl Acad Sci U S A 99(11):7604-9. [PubMed: 12032330]  [MGI Ref ID J:76860]

Joyce CW; Amar MJ; Lambert G; Vaisman BL; Paigen B; Najib-Fruchart J; Hoyt RF Jr; Neufeld ED; Remaley AT; Fredrickson DS; Brewer HB Jr; Santamarina-Fojo S. 2002. The ATP binding cassette transporter A1 (ABCA1) modulates the development of aortic atherosclerosis in C57BL/6 and apoE-knockout mice. Proc Natl Acad Sci U S A 99(1):407-12. [PubMed: 11752403]  [MGI Ref ID J:73704]

Karackattu SL; Picard MH; Krieger M. 2005. Lymphocytes are not required for the rapid onset of coronary heart disease in scavenger receptor class B type I/apolipoprotein E double knockout mice. Arterioscler Thromb Vasc Biol 25(4):803-8. [PubMed: 15692099]  [MGI Ref ID J:110023]

Karackattu SL; Trigatti B; Krieger M. 2006. Hepatic lipase deficiency delays atherosclerosis, myocardial infarction, and cardiac dysfunction and extends lifespan in SR-BI/apolipoprotein E double knockout mice. Arterioscler Thromb Vasc Biol 26(3):548-54. [PubMed: 16397139]  [MGI Ref ID J:127979]

Karra R; Vemullapalli S; Dong C; Herderick EE; Song X; Slosek K; Nevins JR; West M; Goldschmidt-Clermont PJ; Seo D. 2005. Molecular evidence for arterial repair in atherosclerosis. Proc Natl Acad Sci U S A 102(46):16789-94. [PubMed: 16275914]  [MGI Ref ID J:103741]

Kauser K; da Cunha V; Fitch R; Mallari C; Rubanyi GM. 2000. Role of endogenous nitric oxide in progression of atherosclerosis in apolipoprotein E-deficient mice. Am J Physiol Heart Circ Physiol 278(5):H1679-85. [PubMed: 10775149]  [MGI Ref ID J:62352]

Keller JN; Lauderback CM; Butterfield DA; Kindy MS; Yu J; Markesbery WR. 2000. Amyloid beta-peptide effects on synaptosomes from apolipoprotein E-deficient mice. J Neurochem 74(4):1579-86. [PubMed: 10737615]  [MGI Ref ID J:61167]

Khallou-Laschet J; Caligiuri G; Groyer E; Tupin E; Gaston AT; Poirier B; Kronenberg M; Cohen JL; Klatzmann D; Kaveri SV; Nicoletti A. 2006. The proatherogenic role of T cells requires cell division and is dependent on the stage of the disease. Arterioscler Thromb Vasc Biol 26(2):353-8. [PubMed: 16322528]  [MGI Ref ID J:127968]

Kim E; Tolhurst AT; Qin LY; Chen XY; Febbraio M; Cho S. 2008. CD36/fatty acid translocase, an inflammatory mediator, is involved in hyperlipidemia-induced exacerbation in ischemic brain injury. J Neurosci 28(18):4661-70. [PubMed: 18448643]  [MGI Ref ID J:134972]

Kindy MS; Rader DJ. 1998. Reduction in amyloid A amyloid formation in apolipoprotein-E-deficient mice [see comments] Am J Pathol 152(5):1387-95. [PubMed: 9588907]  [MGI Ref ID J:47401]

King VL; Cassis LA; Daugherty A. 2007. Interleukin-4 does not influence development of hypercholesterolemia or angiotensin II-induced atherosclerotic lesions in mice. Am J Pathol 171(6):2040-7. [PubMed: 18055554]  [MGI Ref ID J:128948]

Kirii H; Niwa T; Yamada Y; Wada H; Saito K; Iwakura Y; Asano M; Moriwaki H; Seishima M. 2003. Lack of interleukin-1beta decreases the severity of atherosclerosis in ApoE-deficient mice. Arterioscler Thromb Vasc Biol 23(4):656-60. [PubMed: 12615675]  [MGI Ref ID J:103057]

Kirk EA; Heinecke JW; LeBoeuf RC. 2001. Iron overload diminishes atherosclerosis in apoE-deficient mice. J Clin Invest 107(12):1545-53. [PubMed: 11413162]  [MGI Ref ID J:70613]

Klement H; St Croix B; Milsom C; May L; Guo Q; Yu JL; Klement P; Rak J. 2007. Atherosclerosis and vascular aging as modifiers of tumor progression, angiogenesis, and responsiveness to therapy. Am J Pathol 171(4):1342-51. [PubMed: 17823292]  [MGI Ref ID J:125516]

Knaapen AM; Curfs DM; Pachen DM; Gottschalk RW; de Winther MP; Daemen MJ; Van Schooten FJ. 2007. The environmental carcinogen benzo[a]pyrene induces expression of monocyte-chemoattractant protein-1 in vascular tissue: a possible role in atherogenesis. Mutat Res 621(1-2):31-41. [PubMed: 17376491]  [MGI Ref ID J:123179]

Knowles JW; Reddick RL; Jennette JC; Shesely EG; Smithies O; Maeda N. 2000. Enhanced atherosclerosis and kidney dysfunction in eNOS(-/-)Apoe(-/-) mice are ameliorated by enalapril treatment. J Clin Invest 105(4):451-8. [PubMed: 10683374]  [MGI Ref ID J:60670]

Ko KW; Paul A; Ma K; Li L; Chan L. 2005. Endothelial lipase modulates HDL but has no effect on atherosclerosis development in apoE-/- and LDLR-/- mice. J Lipid Res 46(12):2586-94. [PubMed: 16199802]  [MGI Ref ID J:106132]

Koistinaho M; Kettunen MI; Holtzman DM; Kauppinen RA; Higgins LS; Koistinaho J. 2002. Expression of human apolipoprotein E downregulates amyloid precursor protein-induced ischemic susceptibility. Stroke 33(7):1905-10. [PubMed: 12105373]  [MGI Ref ID J:133156]

Koistinaho M; Lin S; Wu X; Esterman M; Koger D; Hanson J; Higgs R; Liu F; Malkani S; Bales KR; Paul SM. 2004. Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides. Nat Med 10(7):719-26. [PubMed: 15195085]  [MGI Ref ID J:91799]

Kraemer R; Baker PJ; Kent KC; Ye Y; Han JJ; Tejada R; Silane M; Upmacis R; Deeb R; Chen Y; Levine DM; Hempstead B. 2005. Decreased neurotrophin TrkB receptor expression reduces lesion size in the apolipoprotein E-null mutant mouse. Circulation 112(23):3644-53. [PubMed: 16330706]  [MGI Ref ID J:116881]

Krebs P; Scandella E; Bolinger B; Engeler D; Miller S; Ludewig B. 2007. Chronic immune reactivity against persisting microbial antigen in the vasculature exacerbates atherosclerotic lesion formation. Arterioscler Thromb Vasc Biol 27(10):2206-13. [PubMed: 17656668]  [MGI Ref ID J:134893]

Krzywkowski P; Ghribi O; Gagne J; Chabot C; Kar S; Rochford J; Massicotte G; Poirier J. 1999. Cholinergic systems and long-term potentiation in memory-impaired apolipoprotein E-deficient mice. Neuroscience 92(4):1273-86. [PubMed: 10426483]  [MGI Ref ID J:110875]

Kuhlencordt PJ; Chen J; Han F; Astern J; Huang PL. 2001. Genetic deficiency of inducible nitric oxide synthase reduces atherosclerosis and lowers plasma lipid peroxides in apolipoprotein E-knockout mice. Circulation 103(25):3099-104. [PubMed: 11425775]  [MGI Ref ID J:103350]

Kuhlencordt PJ; Gyurko R; Han F; Scherrer-Crosbie M; Aretz TH; Hajjar R; Picard MH; Huang PL. 2001. Accelerated atherosclerosis, aortic aneurysm formation, and ischemic heart disease in apolipoprotein E/endothelial nitric oxide synthase double-knockout mice. Circulation 104(4):448-54. [PubMed: 11468208]  [MGI Ref ID J:103306]

Kunieda T; Minamino T; Nishi J; Tateno K; Oyama T; Katsuno T; Miyauchi H; Orimo M; Okada S; Takamura M; Nagai T; Kaneko S; Komuro I. 2006. Angiotensin II induces premature senescence of vascular smooth muscle cells and accelerates the development of atherosclerosis via a p21-dependent pathway. Circulation 114(9):953-60. [PubMed: 16908765]  [MGI Ref ID J:125247]

Kunjathoor VV; Chiu DS; O'Brien KD; LeBoeuf RC. 2002. Accumulation of biglycan and perlecan, but not versican, in lesions of murine models of atherosclerosis. Arterioscler Thromb Vasc Biol 22(3):462-8. [PubMed: 11884291]  [MGI Ref ID J:103309]

Kypreos KE; Li X; van Dijk KW; Havekes LM; Zannis VI. 2003. Molecular mechanisms of type III hyperlipoproteinemia: The contribution of the carboxy-terminal domain of ApoE can account for the dyslipidemia that is associated with the E2/E2 phenotype. Biochemistry 42(33):9841-53. [PubMed: