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NOD mice homozygous for the Ighm tm1Cgn allele do not express membrane-bound IgM, lack mature B-cells, are free of insulitis, and do not develop IDDM.


The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names NOD.129S2(B6)-Igh-6tm1Cgn/DoiJ    (Changed: 30-NOV-10 )
Type Congenic; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain NOD
Donor Strain 129P2
H2 Haplotypeg7
Donating Investigator Christophe Benoist,   Joslin Diabetes Center

albino, pink-eyed
Related Genotype: A/A Tyrc/Tyrc

NOD mice homozygous for the Ighm tm1Cgn allele do not express membrane-bound IgM. Ighm deficient mice lack mature B-cells, although some B-cells may be produced using a C gene other than mu. These mice are virtually free of insulitis: at most, presence of only perivascular/periductal leukocytes is detected. No intra-islet infiltrates are found. Results indicate that insulin dependant diabetes mellitus (IDDM) is not delayed, but prevented because of a lack of B cell autoreactive T cell responses. Therefore, the elimination of B lymphocytes by congenic transfer of the Ighm tm1Cgn mutation is sufficient to block IDDM development in an otherwise susceptible NOD mouse strain. (Kitamura 1991, Serreze 1996)

The Ighmgene was disrupted by insertion of a translational stop codon and neomycin-resistence gene close to the 5? boundary of the first exon. The disrupted gene was transfected into D3 ES cells (derived from 129S2/SvPas). Male founders were bred and maintained on a C57BL/6 prior to backcross onto NOD/Lt for 14 generations. The Ighmtm1Cgn allele is maintained homozygous by brother-sister mating. (Kitamura 1991)

Control Information

   001976 NOD/ShiLtJ
  Considerations for Choosing Controls

Related Strains

View Strains carrying   Ighmtm1Cgn     (8 strains)

View Strains carrying other alleles of Ighm     (8 strains)


Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
Models with phenotypic similarity to human diseases where etiology is unknown or involving genes where ortholog is unknown.
Diabetes Mellitus, Insulin-Dependent; IDDM
- No similarity to the expected human disease phenotype was found. One or more human genes are associated with this human disease. The mouse genotype may involve mutations to orthologs of one or more of these genes, but the phenotype did not resemble the disease.
Diabetes Mellitus, Insulin-Dependent; IDDM
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Agammaglobulinemia 1, Autosomal Recessive; AGM1   (IGHM)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype


  • immune system phenotype
  • increased susceptibility to autoimmune diabetes
    • 90% of female and 45% of male heterozygotes develop diabetes (glycosuric values >3) by 20 weeks of age compared to 0% of homozygotes   (MGI Ref ID J:37287)


  • immune system phenotype
  • decreased susceptibility to autoimmune diabetes
    • no male or female homozygotes develop diabetes (assessed by glycosuric levels >3) by 20 weeks of age   (MGI Ref ID J:37287)


  • immune system phenotype
  • abnormal T cell number
    • the proportion, but not the number, of CD 4 and CD8 T cells found in the spleen is increased due to the absence of B cells   (MGI Ref ID J:80859)
  • abnormal T cell proliferation
    • T cells fail to proliferate when splenocytes are cultured in vitro with the diabetes autoantigen GAD   (MGI Ref ID J:80859)
  • abnormal spleen B cell follicle morphology
    • follicles do not develop in the spleen   (MGI Ref ID J:80859)
  • absent B cells
    • B cells are absent in the spleen   (MGI Ref ID J:80859)
  • decreased susceptibility to autoimmune diabetes
    • 13.6% of female mice develop diabetes by 21 weeks of age compared to control NOD mice that have an incidence rate of 95.5% at this age   (MGI Ref ID J:80859)
  • hematopoietic system phenotype
  • abnormal T cell number
    • the proportion, but not the number, of CD 4 and CD8 T cells found in the spleen is increased due to the absence of B cells   (MGI Ref ID J:80859)
  • abnormal T cell proliferation
    • T cells fail to proliferate when splenocytes are cultured in vitro with the diabetes autoantigen GAD   (MGI Ref ID J:80859)
  • abnormal spleen B cell follicle morphology
    • follicles do not develop in the spleen   (MGI Ref ID J:80859)
  • absent B cells
    • B cells are absent in the spleen   (MGI Ref ID J:80859)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.


  • endocrine/exocrine gland phenotype
  • insulitis
    • mice display insulitis starting at 8 weeks; insulitis is milder than that observed in NOD control mice   (MGI Ref ID J:93190)
  • immune system phenotype
  • insulitis
    • mice display insulitis starting at 8 weeks; insulitis is milder than that observed in NOD control mice   (MGI Ref ID J:93190)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Diabetes and Obesity Research
Type 1 Diabetes (IDDM)

Ighmtm1Cgn related

Immunology, Inflammation and Autoimmunity Research
      B cell deficiency

Research Tools
Cancer Research
      B cell deficiency
Immunology, Inflammation and Autoimmunity Research
      B cell deficiency

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol Ighmtm1Cgn
Allele Name targeted mutation 1, University of Cologne
Allele Type Targeted (Null/Knockout)
Common Name(s) B cell-; BCKO; BCR-; BKO; Cmu -; Ig- muMT; Ig-; IgH-; IgHmuMT; Igh-6-; Igh-6null; Igh-6tm1Cgn; Igh-6tm1CgnmuMT0; Ighm-; Igmunull; mu-MT-; muIgKO; muMT; muMt-; mum-;
Mutation Made By Daisuke Kitamura,   University of Cologne
Strain of Origin129S2/SvPas
ES Cell Line NameD3
ES Cell Line Strain129S2/SvPas
Gene Symbol and Name Ighm, immunoglobulin heavy constant mu
Chromosome 12
Gene Common Name(s) AI326478; BCR; Ig mu; IgM; Igh-6; Igh-M; Igh6; expressed sequence AI326478; immunoglobulin heavy chain 6 (heavy chain of IgM); immunoglobulin heavy chain mu; muH; muMT;
Molecular Note A neomycin resistance cassette disrupted one of the membrane exons of the gene encoding immunoglobulin heavy chain of the class mu (IgM). [MGI Ref ID J:110548] [MGI Ref ID J:70398]


Genotyping Information

Genotyping Protocols

Igh-6tm1Cgn, Standard PCR

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Additional References

Ighmtm1Cgn related

Abraham D; Leon O; Schnyder-Candrian S; Wang CC; Galioto AM; Kerepesi LA; Lee JJ; Lustigman S. 2004. Immunoglobulin E and eosinophil-dependent protective immunity to larval Onchocerca volvulus in mice immunized with irradiated larvae. Infect Immun 72(2):810-7. [PubMed: 14742524]  [MGI Ref ID J:87861]

Akashi T; Nagafuchi S; Anzai K; Kitamura D; Wang J; Taniuchi I; Niho Y; Watanabe T. 1998. Proliferation of CD3+ B220- single-positive normal T cells was suppressed in B-cell-deficient lpr mice. Immunology 93(2):238-48. [PubMed: 9616374]  [MGI Ref ID J:45808]

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Allen HL; Deepe GS Jr. 2006. B cells and CD4-CD8- T cells are key regulators of the severity of reactivation histoplasmosis. J Immunol 177(3):1763-71. [PubMed: 16849486]  [MGI Ref ID J:138028]

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Ando T; Matsumoto K; Namiranian S; Yamashita H; Glatthorn H; Kimura M; Dolan BR; Lee JJ; Galli SJ; Kawakami Y; Jamora C; Kawakami T. 2013. Mast Cells Are Required for Full Expression of Allergen/SEB-Induced Skin Inflammation. J Invest Dermatol 133(12):2695-705. [PubMed: 23752044]  [MGI Ref ID J:202870]

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Ankeny DP; Guan Z; Popovich PG. 2009. B cells produce pathogenic antibodies and impair recovery after spinal cord injury in mice. J Clin Invest 119(10):2990-9. [PubMed: 19770513]  [MGI Ref ID J:154634]

Archer NK; Harro JM; Shirtliff ME. 2013. Clearance of Staphylococcus aureus nasal carriage is T cell dependent and mediated through interleukin-17A expression and neutrophil influx. Infect Immun 81(6):2070-5. [PubMed: 23529621]  [MGI Ref ID J:199531]

Aroeira LS; Mouton CG; Toran JL; Ward ES; Martinez C. 1999. Anti-Vbeta8 antibodies induce and maintain staphylococcal enterotoxin B-triggered Vbeta8+ T cell anergy. Eur J Immunol 29(2):437-45. [PubMed: 10064059]  [MGI Ref ID J:115226]

Arras M; Louahed J; Heilier JF; Delos M; Brombacher F; Renauld JC; Lison D; Huaux F. 2005. IL-9 protects against bleomycin-induced lung injury: involvement of prostaglandins. Am J Pathol 166(1):107-15. [PubMed: 15632004]  [MGI Ref ID J:95244]

Arras M; Louahed J; Simoen V; Barbarin V; Misson P; van den Brule S; Delos M; Knoops L; Renauld JC; Lison D; Huaux F. 2006. B lymphocytes are critical for lung fibrosis control and prostaglandin E2 regulation in IL-9 transgenic mice. Am J Respir Cell Mol Biol 34(5):573-80. [PubMed: 16424385]  [MGI Ref ID J:136512]

Asano MS; Ahmed R. 1996. CD8 T cell memory in B cell-deficient mice. J Exp Med 183(5):2165-74. [PubMed: 8642326]  [MGI Ref ID J:33136]

Ashbaugh JJ; Brambilla R; Karmally SA; Cabello C; Malek TR; Bethea JR. 2013. IL7Ralpha Contributes to Experimental Autoimmune Encephalomyelitis through Altered T Cell Responses and Nonhematopoietic Cell Lineages. J Immunol 190(9):4525-34. [PubMed: 23530149]  [MGI Ref ID J:195519]

Ashour HM; Niederkorn JY. 2006. Peripheral tolerance via the anterior chamber of the eye: role of B cells in MHC class I and II antigen presentation. J Immunol 176(10):5950-7. [PubMed: 16670303]  [MGI Ref ID J:131707]

Aurora AB; Baluk P; Zhang D; Sidhu SS; Dolganov GM; Basbaum C; McDonald DM; Killeen N. 2005. Immune complex-dependent remodeling of the airway vasculature in response to a chronic bacterial infection. J Immunol 175(10):6319-26. [PubMed: 16272283]  [MGI Ref ID J:119344]

Bajenoff M; Germain RN. 2009. B-cell follicle development remodels the conduit system and allows soluble antigen delivery to follicular dendritic cells. Blood 114(24):4989-97. [PubMed: 19713459]  [MGI Ref ID J:155014]

Ballesteros-Tato A; Leon B; Lund FE; Randall TD. 2013. CD4+ T helper cells use CD154-CD40 interactions to counteract T reg cell-mediated suppression of CD8+ T cell responses to influenza. J Exp Med 210(8):1591-601. [PubMed: 23835849]  [MGI Ref ID J:202249]

Barker TT; Lee PY; Kelly-Scumpia KM; Weinstein JS; Nacionales DC; Kumagai Y; Akira S; Croker BP; Sobel ES; Reeves WH; Satoh M. 2011. Pathogenic role of B cells in the development of diffuse alveolar hemorrhage induced by pristane. Lab Invest 91(10):1540-50. [PubMed: 21808234]  [MGI Ref ID J:176270]

Barr TA; Brown S; Mastroeni P; Gray D. 2009. B cell intrinsic MyD88 signals drive IFN-gamma production from T cells and control switching to IgG2c. J Immunol 183(2):1005-12. [PubMed: 19542370]  [MGI Ref ID J:151505]

Barr TA; Brown S; Mastroeni P; Gray D. 2010. TLR and B cell receptor signals to B cells differentially program primary and memory Th1 responses to Salmonella enterica. J Immunol 185(5):2783-9. [PubMed: 20675594]  [MGI Ref ID J:163256]

Basu S; Ray A; Dittel BN. 2011. Cannabinoid receptor 2 is critical for the homing and retention of marginal zone B lineage cells and for efficient T-independent immune responses. J Immunol 187(11):5720-32. [PubMed: 22048769]  [MGI Ref ID J:179699]

Batten M; Ramamoorthi N; Kljavin NM; Ma CS; Cox JH; Dengler HS; Danilenko DM; Caplazi P; Wong M; Fulcher DA; Cook MC; King C; Tangye SG; de Sauvage FJ; Ghilardi N. 2010. IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells. J Exp Med 207(13):2895-906. [PubMed: 21098093]  [MGI Ref ID J:176869]

Baumgarth N; Jager GC; Herman OC; Herzenberg LA. 2000. CD4+ T cells derived from B cell-deficient mice inhibit the establishment of peripheral B cell pools. Proc Natl Acad Sci U S A 97(9):4766-71. [PubMed: 10781082]  [MGI Ref ID J:61947]

Beland JL; Sobel RA; Adler H; Del-Pan NC; Rimm IJ. 1999. B cell-deficient mice have increased susceptibility to HSV-1 encephalomyelitis and mortality. J Neuroimmunol 94(1-2):122-6. [PubMed: 10376944]  [MGI Ref ID J:102971]

Belperron AA; Bockenstedt LK. 2001. Natural Antibody Affects Survival of the Spirochete Borrelia burgdorferi within Feeding Ticks. Infect Immun 69(10):6456-62. [PubMed: 11553590]  [MGI Ref ID J:71569]

Bergmann CC; Ramakrishna C; Kornacki M; Stohlman SA. 2001. Impaired T cell immunity in B cell-deficient mice following viral central nervous system infection. J Immunol 167(3):1575-83. [PubMed: 11466379]  [MGI Ref ID J:120484]

Bergthaler A; Flatz L; Verschoor A; Hegazy AN; Holdener M; Fink K; Eschli B; Merkler D; Sommerstein R; Horvath E; Fernandez M; Fitsche A; Senn BM; Verbeek JS; Odermatt B; Siegrist CA; Pinschewer DD. 2009. Impaired antibody response causes persistence of prototypic T cell-contained virus. PLoS Biol 7(4):e1000080. [PubMed: 19355789]  [MGI Ref ID J:150498]

Beutner U; Kraus E; Kitamura D; Rajewsky K; Huber BT. 1994. B cells are essential for murine mammary tumor virus transmission, but not for presentation of endogenous superantigens. J Exp Med 179(5):1457-66. [PubMed: 8163931]  [MGI Ref ID J:110774]

Bhattacharya D; Rossi DJ; Bryder D; Weissman IL. 2006. Purified hematopoietic stem cell engraftment of rare niches corrects severe lymphoid deficiencies without host conditioning. J Exp Med 203(1):73-85. [PubMed: 16380511]  [MGI Ref ID J:118834]

Binder GK; Griffin DE. 2001. Interferon-gamma-mediated site-specific clearance of alphavirus from CNS neurons. Science 293(5528):303-6. [PubMed: 11452126]  [MGI Ref ID J:125465]

Binstadt BA; Hebert JL; Ortiz-Lopez A; Bronson R; Benoist C; Mathis D. 2009. The same systemic autoimmune disease provokes arthritis and endocarditis via distinct mechanisms. Proc Natl Acad Sci U S A 106(39):16758-63. [PubMed: 19805369]  [MGI Ref ID J:153217]

Bitsaktsis C; Nandi B; Racine R; MacNamara KC; Winslow G. 2007. T-Cell-independent humoral immunity is sufficient for protection against fatal intracellular ehrlichia infection. Infect Immun 75(10):4933-41. [PubMed: 17664264]  [MGI Ref ID J:125283]

Bitsaktsis C; Rawool DB; Li Y; Kurkure NV; Iglesias B; Gosselin EJ. 2009. Differential requirements for protection against mucosal challenge with Francisella tularensis in the presence versus absence of cholera toxin B and inactivated F. tularensis. J Immunol 182(8):4899-909. [PubMed: 19342669]  [MGI Ref ID J:147502]

Bodhankar S; Wang C; Vandenbark AA; Offner H. 2011. Estrogen-induced protection against experimental autoimmune encephalomyelitis is abrogated in the absence of B cells. Eur J Immunol 41(4):1165-75. [PubMed: 21413005]  [MGI Ref ID J:175416]

Boenisch O; D'Addio F; Watanabe T; Elyaman W; Magee CN; Yeung MY; Padera RF; Rodig SJ; Murayama T; Tanaka K; Yuan X; Ueno T; Jurisch A; Mfarrej B; Akiba H; Yagita H; Najafian N. 2010. TIM-3: a novel regulatory molecule of alloimmune activation. J Immunol 185(10):5806-19. [PubMed: 20956339]  [MGI Ref ID J:165781]

Bommireddy R; Engle SJ; Ormsby I; Boivin GP; Babcock GF; Doetschman T. 2004. Elimination of both CD4(+) and CD8(+) T cells but not B cells eliminates inflammation and prolongs the survival of TGFbeta1-deficient mice. Cell Immunol 232(1-2):96-104. [PubMed: 15922720]  [MGI Ref ID J:99033]

Borchers MT; Crosby J; Justice P; Farmer S; Hines E; Lee JJ; Lee NA. 2001. Intrinsic AHR in IL-5 transgenic mice is dependent on CD4(+) cells and CD49d-mediated signaling. Am J Physiol Lung Cell Mol Physiol 281(3):L653-9. [PubMed: 11504693]  [MGI Ref ID J:132284]

Borenstein SH; Graham J; Zhang XL; Chamberlain JW. 2000. CD8+ T cells are necessary for recognition of allelic, but not locus-mismatched or xeno-, HLA class I transplantation antigens. J Immunol 165(5):2341-53. [PubMed: 10946256]  [MGI Ref ID J:80678]

Bosio CM; Elkins KL. 2001. Susceptibility to secondary Francisella tularensis live vaccine strain infection in B-cell-deficient mice is associated with neutrophilia but not with defects in specific T-cell-mediated immunity. Infect Immun 69(1):194-203. [PubMed: 11119506]  [MGI Ref ID J:67757]

Bowne WB; Srinivasan R; Wolchok JD; Hawkins WG; Blachere NE; Dyall R; Lewis JJ; Houghton AN. 1999. Coupling and uncoupling of tumor immunity and autoimmunity. J Exp Med 190(11):1717-22. [PubMed: 10587362]  [MGI Ref ID J:115120]

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Briesemeister D; Friese C; Isern CC; Dietz E; Blankenstein T; Thoene-Reineke C; Kammertoens T. 2012. Differences in serum cytokine levels between wild type mice and mice with a targeted mutation suggests necessity of using control littermates. Cytokine 60(3):626-33. [PubMed: 22902947]  [MGI Ref ID J:192770]

Brodie GM; Wallberg M; Santamaria P; Wong FS; Green EA. 2008. B-cells promote intra-islet CD8+ cytotoxic T-cell survival to enhance type 1 diabetes. Diabetes 57(4):909-17. [PubMed: 18184927]  [MGI Ref ID J:135342]

Brundler MA; Aichele P; Bachmann M; Kitamura D; Rajewsky K; Zinkernagel RM. 1996. Immunity to viruses in B cell-deficient mice: influence of antibodies on virus persistence and on T cell memory. Eur J Immunol 26(9):2257-62. [PubMed: 8814275]  [MGI Ref ID J:112980]

Bry L; Brenner MB. 2004. Critical role of T cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving acute mucosal infection with Citrobacter rodentium, an attaching and effacing pathogen. J Immunol 172(1):433-41. [PubMed: 14688352]  [MGI Ref ID J:87077]

Burdeinick-Kerr R; Wind J; Griffin DE. 2007. Synergistic roles of antibody and interferon in noncytolytic clearance of Sindbis virus from different regions of the central nervous system. J Virol 81(11):5628-36. [PubMed: 17376910]  [MGI Ref ID J:153321]

Burne-Taney MJ; Ascon DB; Daniels F; Racusen L; Baldwin W; Rabb H. 2003. B cell deficiency confers protection from renal ischemia reperfusion injury. J Immunol 171(6):3210-5. [PubMed: 12960350]  [MGI Ref ID J:85388]

Capasso M; Bhamrah MK; Henley T; Boyd RS; Langlais C; Cain K; Dinsdale D; Pulford K; Khan M; Musset B; Cherny VV; Morgan D; Gascoyne RD; Vigorito E; DeCoursey TE; MacLennan IC; Dyer MJ. 2010. HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species. Nat Immunol 11(3):265-72. [PubMed: 20139987]  [MGI Ref ID J:158627]

Cardoso CR; Provinciatto PR; Godoi DF; Vieira TS; Ferreira BR; Teixeira G; Rossi MA; Cunha FQ; Silva JS. 2008. B cells are involved in the modulation of pathogenic gut immune response in food-allergic enteropathy. Clin Exp Immunol 154(2):153-61. [PubMed: 18778361]  [MGI Ref ID J:142417]

Cato MH; Chintalapati SK; Yau IW; Omori SA; Rickert RC. 2011. Cyclin D3 is selectively required for proliferative expansion of germinal center B cells. Mol Cell Biol 31(1):127-37. [PubMed: 20956554]  [MGI Ref ID J:169426]

Ceredig R; Andersson J; Melchers F; Rolink A. 1999. Effect of deregulated IL-7 transgene expression on B lymphocyte development in mice expressing mutated pre-B cell receptors. Eur J Immunol 29(9):2797-807. [PubMed: 10508254]  [MGI Ref ID J:57690]

Cernetich A; Garver LS; Jedlicka AE; Klein PW; Kumar N; Scott AL; Klein SL. 2006. Involvement of gonadal steroids and gamma interferon in sex differences in response to blood-stage malaria infection. Infect Immun 74(6):3190-203. [PubMed: 16714546]  [MGI Ref ID J:109239]

Cervantes-Barragan L; Gil-Cruz C; Pastelin-Palacios R; Lang KS; Isibasi A; Ludewig B; Lopez-Macias C. 2009. TLR2 and TLR4 signaling shapes specific antibody responses to Salmonella typhi antigens. Eur J Immunol 39(1):126-35. [PubMed: 19130558]  [MGI Ref ID J:143726]

Cervantes-Barragan L; Lewis KL; Firner S; Thiel V; Hugues S; Reith W; Ludewig B; Reizis B. 2012. Plasmacytoid dendritic cells control T-cell response to chronic viral infection. Proc Natl Acad Sci U S A 109(8):3012-7. [PubMed: 22315415]  [MGI Ref ID J:182008]

Chan EA; Teng G; Corbett E; Choudhury KR; Bassing CH; Schatz DG; Krangel MS. 2013. Peripheral subnuclear positioning suppresses Tcrb recombination and segregates Tcrb alleles from RAG2. Proc Natl Acad Sci U S A 110(48):E4628-37. [PubMed: 24218622]  [MGI Ref ID J:203055]

Chan OT; Hannum LG; Haberman AM; Madaio MP; Shlomchik MJ. 1999. A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus. J Exp Med 189(10):1639-48. [PubMed: 10330443]  [MGI Ref ID J:55066]

Chao TK; Rifai A; Ka SM; Yang SM; Shui HA; Lin YF; Sytwu HK; Lee WH; Kung JT; Chen A. 2006. The endogenous immune response modulates the course of IgA-immune complex mediated nephropathy. Kidney Int 70(2):283-97. [PubMed: 16738538]  [MGI Ref ID J:136494]

Chen K; McAleer JP; Lin Y; Paterson DL; Zheng M; Alcorn JF; Weaver CT; Kolls JK. 2011. Th17 cells mediate clade-specific, serotype-independent mucosal immunity. Immunity 35(6):997-1009. [PubMed: 22195749]  [MGI Ref ID J:179276]

Chen Y; Park YB; Patel E; Silverman GJ. 2009. IgM antibodies to apoptosis-associated determinants recruit C1q and enhance dendritic cell phagocytosis of apoptotic cells. J Immunol 182(10):6031-43. [PubMed: 19414754]  [MGI Ref ID J:148245]

Chen YG; Silveira PA; Osborne MA; Chapman HD; Serreze DV. 2007. Cellular expression requirements for inhibition of type 1 diabetes by a dominantly protective major histocompatibility complex haplotype. Diabetes 56(2):424-30. [PubMed: 17259387]  [MGI Ref ID J:121957]

Chen Z; Yu S; Concha HQ; Zhu Y; Mix E; Winblad B; Ljunggren HG; Zhu J. 2004. Kainic acid-induced excitotoxic hippocampal neurodegeneration in C57BL/6 mice: B cell and T cell subsets may contribute differently to the pathogenesis. Brain Behav Immun 18(2):175-85. [PubMed: 14759595]  [MGI Ref ID J:105331]

Chiarle R; Martinengo C; Mastini C; Ambrogio C; D'Escamard V; Forni G; Inghirami G. 2008. The anaplastic lymphoma kinase is an effective oncoantigen for lymphoma vaccination. Nat Med 14(6):676-80. [PubMed: 18469826]  [MGI Ref ID J:136968]

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Zhu Y; Bao L; Zhu S; Chen Z; van der Meide P; Nennesmo I; Winblad B; Ljunggren HG; Zhu J. 2002. CD4 and CD8 T cells, but not B cells, are critical to the control of murine experimental autoimmune neuritis. Exp Neurol 177(1):314-20. [PubMed: 12429233]  [MGI Ref ID J:118779]

Zindl CL; Kim TH; Zeng M; Archambault AS; Grayson MH; Choi K; Schreiber RD; Chaplin DD. 2009. The lymphotoxin LTalpha(1)beta(2) controls postnatal and adult spleen marginal sinus vascular structure and function. Immunity 30(3):408-20. [PubMed: 19303389]  [MGI Ref ID J:147033]

Zola TA; Lysenko ES; Weiser JN. 2008. Mucosal clearance of capsule-expressing bacteria requires both TLR and nucleotide-binding oligomerization domain 1 signaling. J Immunol 181(11):7909-16. [PubMed: 19017981]  [MGI Ref ID J:142379]

Zou X; Osborn MJ; Bolland DJ; Smith JA; Corcos D; Hamon M; Oxley D; Hutchings A; Morgan G; Santos F; Kilshaw PJ; Taussig MJ; Corcoran AE; Bruggemann M. 2007. Heavy chain-only antibodies are spontaneously produced in light chain-deficient mice. J Exp Med 204(13):3271-83. [PubMed: 18086860]  [MGI Ref ID J:130864]

Zou X; Smith JA; Nguyen VK; Ren L; Luyten K; Muyldermans S; Bruggemann M. 2005. Expression of a dromedary heavy chain-only antibody and B cell development in the mouse. J Immunol 175(6):3769-79. [PubMed: 16148123]  [MGI Ref ID J:116727]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

Pricing for USA, Canada and Mexico shipping destinations View International Pricing


Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2625.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $1725.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing


Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3412.50
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $2242.50

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

General Supply Notes

Control Information

   001976 NOD/ShiLtJ
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use

General Terms and Conditions

For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries regarding Terms of Use

Contracts Administration


JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty


In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.