Strain Name:

NOD.Cg Prkdcscid-Tg(CSF2)2Ygy Tg(IL3)1Ygy Tg(KITLG)3Ygy/YgyJ

Stock Number:


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The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names CB17.Cg-Prkdcscid Tg(IL3)1Ygy Tg(CSF2)2Ygy Tg(KITLG)3Ygy    (Changed: 26-APR-06 )
Type Congenic; Spontaneous Mutation; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain NOD.CB17-Prkdcscid
Donor Strain NIH/Swiss
H2 Haplotypeg7

albino, pink-eyed
Related Genotype: A/A Tyrc/Tyrc

Tg(IL3)1Ygy, Tg(CSF2)2Ygy, and Tg(KITLG)3Ygy encode porcine interleukin 3 (IL3), Porcine granulocyte macrophage-colony stimulating factor (CSF2, commonly designated GM-CSF) and soluble Porcine stem cell factor (KITLG, commonly designated sSCF) respectively. All three are individually driven by the human cytomegalovirus promoter. These three transgenes were co-injected and they co-segregate. RT-PCR detects transgenic expression of porcine IL-3, CSF2 and KITLG in bone marrow and spleen in NOD.Cg Prkdc scid-Tg(IL3)1Ygy Tg(CSF2)2Ygy Tg(KITLG)3Ygy mice. Porcine IL3, CSF2, and KITLG are present in the serum of these mice in levels that can be detected by ELISA. NOD.Cg Prkdc scid-Tg(IL3)1Ygy Tg(CSF2)2Ygy Tg(KITLG)3Ygy/YgyJ not only provide a system in which long-term porcine tissue and stem cell engraftment can be achieved (Abe et al, 2002) but also is a useful tool for evaluating donor-specific tolerance induction by mixed chimerism across xenogeneic barriers (Chen et al, 2000). White blood cells of NOD.Cg Prkdcscid-Tg(IL3)1Ygy Tg(CSF2)2Ygy Tg(KITLG)3Ygy mice are CD4-, CD8-, CD3-, IgM-, CD19- and Mac-1+ by flow cytometric (FMC) analysis. White blood cells of Tg(IL3)1Ygy Tg(CSF2)2Ygy Tg(KITLG)3Ygy mice sub-lethally irradiated, i.v. injected with miniature swine bone marrow cells and i.p. injected with peripheral blood mononuclear cells (PBMC) are swine myeloid CD-2+, class II+ and CD16+ 20 weeks post bone marrow transplant by FMC. Non-transgenic littermates had low levels of chimerism detected at 3 weeks and non-existent at 7 weeks post bone marrow transplant (BMT). At 20 weeks post BMT these transgenic mice revealed high levels of chimerism in the spleen and bone marrow cells, versus no chimerism in any tissue of non-transgenic littermates. Treated transgenic mice showed peak levels of porcine T cell chimerism at 7 weeks post transplantation. Neither B nor T cells were detectable at 20 weeks post transplantation (Chen et al, 2000).

Control Information

   001303 NOD.CB17-Prkdcscid/J
  Considerations for Choosing Controls

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View Strains carrying   Tg(CSF2)2Ygy     (1 strain)

View Strains carrying   Tg(IL3)1Ygy     (1 strain)

View Strains carrying   Tg(KITLG)3Ygy     (1 strain)

View Strains carrying other alleles of KITLG     (3 strains)

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Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Immunodeficiency 26 with or without Neurologic Abnormalities; IMD26   (PRKDC)
- Potential model based on transgenic expression of a human gene that is associated with this disease. Phenotypic similarity to the human disease has not been tested.
Hyperpigmentation with or without Hypopigmentation, Familial Progressive;   (KITLG)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Prkdcscid/Prkdcscid Tg(CSF2)2Ygy/0 Tg(IL3)1Ygy/0 Tg(KITLG)3Ygy/0

        NOD.Cg-Prkdcscid Tg(CSF2)2Ygy Tg(IL3)1Ygy Tg(KITLG)3Ygy
  • immune system phenotype
  • abnormal response to transplant
    • blood of NOD-SCID mouse recipients remains chimeric for porcine hematopoietic cells throughout the length of the experiment (6 weeks):   (MGI Ref ID J:107052)
    • decreased susceptibility to graft versus host disease
      • conditioned mice were injected with splenocytes, or PBMC and BMC from sensitized porcine donors, no recipients showed detectable GVHD   (MGI Ref ID J:107052)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Diabetes and Obesity Research
Type 1 Diabetes (IDDM)

Immunology, Inflammation and Autoimmunity Research
T Cell Receptor Signaling Defects
      B and T cell deficiency, xenograft/transplant host

Prkdcscid related

Immunology, Inflammation and Autoimmunity Research
      B and T cell deficiency

Internal/Organ Research
Lymphoid Tissue Defects
      B and T cell deficiency

Research Tools
Cancer Research
      B and T cell deficiency, xenograft/transplant host
Toxicology Research
      xenograft/transplant host

Virology Research
B and T Cell Deficiency
      AIDS research tool

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol Prkdcscid
Allele Name severe combined immunodeficiency
Allele Type Spontaneous
Common Name(s) SCID;
Strain of OriginC.B-17
Gene Symbol and Name Prkdc, protein kinase, DNA activated, catalytic polypeptide
Chromosome 16
Gene Common Name(s) AI326420; AU019811; DNA-PK; DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH; HYRC; HYRC1; IMD26; XRCC7; doxorubicin nephropathy; dxnph; expressed sequence AI326420; expressed sequence AU019811; p350; scid; severe combined immunodeficiency; slip;
Molecular Note A T-to-A transversion point mutation at a position corresponding to codon 4095 created a premature stop codon. [MGI Ref ID J:35393] [MGI Ref ID J:39329]
Allele Symbol Tg(CSF2)2Ygy
Allele Name transgene insertion 2, Yong-guang Yang
Allele Type Transgenic (Inserted expressed sequence)
Strain of OriginNIH Swiss
Expressed Gene CSF2, colony stimulating factor 2 (granulocyte-macrophage), pig, domestic
Promoter CMV, cytomegalovirus, human
General Note White blood cells from mice that carry this transgene in conjunction with Tg(IL3)1Ygy and Tg(KITLG)3Ygy and thatare also homozygous for Prkdcscid are CD4-, CD8-, CD3-, IgM-, CD19- and Mac-1+ by flow cytometric (FMC) analysis.
Molecular Note The transgene construct contains the porcine colony stimulating factor 2 (granulocyte-macrophage) sequence (CSF2) controlled by the human cytomegalovirus promoter. The Tg(IL3)1Ygy, Tg(CSF2)2Ygy and Tg(KITLG)3Ygy transgenic constructs were co-injected into NIH/Swiss oocytes in David Bodine's lab at NCI. [MGI Ref ID J:94302]
Allele Symbol Tg(IL3)1Ygy
Allele Name transgene insertion 1, Yong-guang Yang
Allele Type Transgenic (Inserted expressed sequence)
Strain of OriginNIH Swiss
Expressed Gene IL3, interleukin 3 (colony-stimulating factor, multiple), pig, domestic
Promoter hCMV, human cytomegalovirus, human
General Note White blood cells from mice that carry this transgene in conjunction with Tg(CSF2)2Ygy and Tg(KITLG)3Ygy and that are also homozygous for Prkdcscid are CD4-, CD8-, CD3-, IgM-, CD19- and Mac-1+ by flow cytometric (FMC) analysis.
Molecular Note The transgene construct contains the porcine interleukin 3 sequence controlled by the human cytomegalovirus promoter. The Tg(IL3)1Ygy, Tg(CSF2)2Ygy and Tg(KITLG)3Ygy transgenic constructs were co-injected into NIH/Swiss oocytes in David Bodine's lab at NCI. [MGI Ref ID J:94302]
Allele Symbol Tg(KITLG)3Ygy
Allele Name transgene insertion 3, Yong-guang Yang
Allele Type Transgenic (Inserted expressed sequence)
Strain of OriginNIH Swiss
Expressed Gene KITLG, KIT ligand, human
Promoter CMV, cytomegalovirus, human
General Note White blood cells from mice that carry this transgene in conjunction with Tg(IL3)1Ygy and Tg(CSF2)2Ygy and thatare also homozygous for Prkdcscid are CD4-, CD8-, CD3-, IgM-, CD19- and Mac-1+ by flow cytometric (FMC) analysis.
Molecular Note The transgene construct contains porcine kit ligand (KITL) controlled by the human cytomegalovirus promoter. The Tg(IL3)1Ygy, Tg(CSF2)2Ygy and Tg(KITLG)3Ygy transgenic constructs were co-injected into NIH/Swiss oocytes in David Bodine's lab at NCI. [MGI Ref ID J:94302]


Genotyping Information

Genotyping Protocols

Tg(CSF2)2Ygy, Melt Curve Analysis
Tg(CSF2)2Ygy, Standard PCR
Tg(IL3)1Ygy, Melt Curve Analysis
Tg(IL3)1Ygy, Standard PCR
Tg(KITLG)3Ygy, Standard PCR

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Selected Reference(s)

Chen AM; Zhou Y; Swenson K; Sachs DH; Sykes M; Yang YG. 2000. Porcine stem cell engraftment and seeding of murine thymus with class II+ cells in mice expressing porcine cytokines: toward tolerance induction across discordant xenogeneic barriers. Transplantation 69(12):2484-90. [PubMed: 10910267]  [MGI Ref ID J:93486]

Additional References

Prkdcscid related

Agerstam H; Jaras M; Andersson A; Johnels P; Hansen N; Lassen C; Rissler M; Gisselsson D; Olofsson T; Richter J; Fan X; Ehinger M; Fioretos T. 2010. Modeling the human 8p11-myeloproliferative syndrome in immunodeficient mice. Blood 116(12):2103-11. [PubMed: 20554971]  [MGI Ref ID J:164507]

Agliano A; Martin-Padura I; Mancuso P; Marighetti P; Rabascio C; Pruneri G; Shultz LD; Bertolini F. 2008. Human acute leukemia cells injected in NOD/LtSz-scid/IL-2Rgamma null mice generate a faster and more efficient disease compared to other NOD/scid-related strains. Int J Cancer 123(9):2222-7. [PubMed: 18688847]  [MGI Ref ID J:142410]

Ahsmann EJ; van Tol MJ; Oudeman-Gruber J; Lokhorst H; Uytdehaag FG; Schuurman HJ; Bloem AC. 1995. The SCID mouse as a model for multiple myeloma. Br J Haematol 89(2):319-27. [PubMed: 7873382]  [MGI Ref ID J:22989]

Akiba H; Takeda K; Kojima Y; Usui Y; Harada N; Yamazaki T; Ma J; Tezuka K; Yagita H; Okumura K. 2005. The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo. J Immunol 175(4):2340-8. [PubMed: 16081804]  [MGI Ref ID J:107507]

Al-Qaoud KM; Fleischer B; Hoerauf A. 1998. The Xid defect imparts susceptibility to experimental murine filariosis--association with a lack of antibody and IL-10 production by B cells in response to phosphorylcholine. Int Immunol 10(1):17-25. [PubMed: 9488152]  [MGI Ref ID J:110480]

Alba A; Puertas MC; Carrillo J; Planas R; Ampudia R; Pastor X; Bosch F; Pujol-Borrell R; Verdaguer J; Vives-Pi M. 2004. IFNbeta accelerates autoimmune type 1 diabetes in nonobese diabetic mice and breaks the tolerance to beta cells in nondiabetes-prone mice. J Immunol 173(11):6667-75. [PubMed: 15557158]  [MGI Ref ID J:94366]

Alfaro MP; Pagni M; Vincent A; Atkinson J; Hill MF; Cates J; Davidson JM; Rottman J; Lee E; Young PP. 2008. The Wnt modulator sFRP2 enhances mesenchymal stem cell engraftment, granulation tissue formation and myocardial repair. Proc Natl Acad Sci U S A 105(47):18366-71. [PubMed: 19017790]  [MGI Ref ID J:142215]

Ali N; Flutter B; Sanchez Rodriguez R; Sharif-Paghaleh E; Barber LD; Lombardi G; Nestle FO. 2012. Xenogeneic graft-versus-host-disease in NOD-scid IL-2Rgammanull mice display a T-effector memory phenotype. PLoS One 7(8):e44219. [PubMed: 22937164]  [MGI Ref ID J:191672]

Alugupalli KR; Gerstein RM; Chen J; Szomolanyi-Tsuda E; Woodland RT; Leong JM. 2003. The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes. J Immunol 170(7):3819-27. [PubMed: 12646649]  [MGI Ref ID J:125443]

Ambrosino E; Spadaro M; Iezzi M; Curcio C; Forni G; Musiani P; Wei WZ; Cavallo F. 2006. Immunosurveillance of Erbb2 carcinogenesis in transgenic mice is concealed by a dominant regulatory T-cell self-tolerance. Cancer Res 66(15):7734-40. [PubMed: 16885376]  [MGI Ref ID J:112102]

Amezcua Vesely MC; Schwartz M; Bermejo DA; Montes CL; Cautivo KM; Kalergis AM; Rawlings DJ; Acosta-Rodriguez EV; Gruppi A. 2012. FcgammaRIIb and BAFF differentially regulate peritoneal B1 cell survival. J Immunol 188(10):4792-800. [PubMed: 22516957]  [MGI Ref ID J:188666]

Amrani A; Verdaguer J; Anderson B; Utsugi T; Bou S; Santamaria P. 1999. Perforin-independent beta-cell destruction by diabetogenic CD8(+) T lymphocytes in transgenic nonobese diabetic mice. J Clin Invest 103(8):1201-9. [PubMed: 10207172]  [MGI Ref ID J:108737]

Anders K; Buschow C; Herrmann A; Milojkovic A; Loddenkemper C; Kammertoens T; Daniel P; Yu H; Charo J; Blankenstein T. 2011. Oncogene-Targeting T Cells Reject Large Tumors while Oncogene Inactivation Selects Escape Variants in Mouse Models of Cancer. Cancer Cell 20(6):755-67. [PubMed: 22172721]  [MGI Ref ID J:178597]

Anderson MG; Nair KS; Amonoo LA; Mehalow A; Trantow CM; Masli S; John SW. 2008. GpnmbR150X allele must be present in bone marrow derived cells to mediate DBA/2J glaucoma. BMC Genet 9:30. [PubMed: 18402690]  [MGI Ref ID J:134670]

Andoh M; Zhang G; Russell-Lodrigue KE; Shive HR; Weeks BR; Samuel JE. 2007. T Cells Are Essential for Bacterial Clearance, and Gamma Interferon, Tumor Necrosis Factor Alpha, and B Cells Are Crucial for Disease Development in Coxiella burnetii Infection in Mice. Infect Immun 75(7):3245-55. [PubMed: 17438029]  [MGI Ref ID J:122426]

Andre MC; Erbacher A; Gille C; Schmauke V; Goecke B; Hohberger A; Mang P; Wilhelm A; Mueller I; Herr W; Lang P; Handgretinger R; Hartwig UF. 2010. Long-term human CD34(+) stem cell-engrafted nonobese diabetic/SCID/IL-2Rgamma(null) mice show impaired CD8(+) T cell maintenance and a functional arrest of immature NK cells. J Immunol 185(5):2710-20. [PubMed: 20668220]  [MGI Ref ID J:163262]

Araki R; Fujimori A; Hamatani K; Mita K; Saito T; Mori M; Fukumura R; Morimyo M; Muto M; Itoh M; Tatsumi K; Abe M. 1997. Nonsense mutation at Tyr-4046 in the DNA-dependent protein kinase catalytic subunit of severe combined immune deficiency mice. Proc Natl Acad Sci U S A 94(6):2438-43. [PubMed: 9122213]  [MGI Ref ID J:39329]

Archer NK; Harro JM; Shirtliff ME. 2013. Clearance of Staphylococcus aureus nasal carriage is T cell dependent and mediated through interleukin-17A expression and neutrophil influx. Infect Immun 81(6):2070-5. [PubMed: 23529621]  [MGI Ref ID J:199531]

Arendt LM; McCready J; Keller PJ; Baker DD; Naber SP; Seewaldt V; Kuperwasser C. 2013. Obesity promotes breast cancer by CCL2-mediated macrophage recruitment and angiogenesis. Cancer Res 73(19):6080-93. [PubMed: 23959857]  [MGI Ref ID J:202607]

Ashkar AA; Di Santo JP; Croy BA. 2000. Interferon gamma contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy [see comments] J Exp Med 192(2):259-70. [PubMed: 10899912]  [MGI Ref ID J:63645]

Aspord C; Rome S; Thivolet C. 2004. Early events in islets and pancreatic lymph nodes in autoimmune diabetes. J Autoimmun 23(1):27-35. [PubMed: 15236750]  [MGI Ref ID J:91668]

Augstein P; Stephens LA; Allison J; Elefanty AG; Ekberg M; Kay TW; Harrison LC. 1998. Beta-cell apoptosis in an accelerated model of autoimmune diabetes. Mol Med 4(8):495-501. [PubMed: 9742505]  [MGI Ref ID J:133840]

Babu S; Porte P; Klei TR; Shultz LD; Rajan TV. 1998. Host NK cells are required for the growth of the human filarial parasite Brugia malayi in mice. J Immunol 161(3):1428-32. [PubMed: 9686607]  [MGI Ref ID J:49819]

Baerenwaldt A; Lux A; Danzer H; Spriewald BM; Ullrich E; Heidkamp G; Dudziak D; Nimmerjahn F. 2011. Fcgamma receptor IIB (FcgammaRIIB) maintains humoral tolerance in the human immune system in vivo. Proc Natl Acad Sci U S A 108(46):18772-7. [PubMed: 22065769]  [MGI Ref ID J:180174]

Baker RL; Delong T; Barbour G; Bradley B; Nakayama M; Haskins K. 2013. Cutting edge: CD4 T cells reactive to an islet amyloid polypeptide peptide accumulate in the pancreas and contribute to disease pathogenesis in nonobese diabetic mice. J Immunol 191(8):3990-4. [PubMed: 24043895]  [MGI Ref ID J:206266]

Balasa B; La Cava A; Van Gunst K; Mocnik L; Balakrishna D; Nguyen N; Tucker L; Sarvetnick N. 2000. A mechanism for IL-10-mediated diabetes in the nonobese diabetic (NOD) mouse: ICAM-1 deficiency blocks accelerated diabetes J Immunol 165(12):7330-7. [PubMed: 11120869]  [MGI Ref ID J:66103]

Balavenkatraman KK; Aceto N; Britschgi A; Mueller U; Bence KK; Neel BG; Bentires-Alj M. 2011. Epithelial protein-tyrosine phosphatase 1B contributes to the induction of mammary tumors by HER2/Neu but is not essential for tumor maintenance. Mol Cancer Res 9(10):1377-84. [PubMed: 21849469]  [MGI Ref ID J:205401]

Baleriola J; Suarez T; de la Rosa EJ. 2010. DNA-PK promotes the survival of young neurons in the embryonic mouse retina. Cell Death Differ 17(11):1697-706. [PubMed: 20448641]  [MGI Ref ID J:186357]

Ballas ZK; Buchta CM; Rosean TR; Heusel JW; Shey MR. 2013. Role of NK cell subsets in organ-specific murine melanoma metastasis. PLoS One 8(6):e65599. [PubMed: 23776508]  [MGI Ref ID J:204234]

Bandeira M; Santos CS; de Azevedo EC; Soares LM; Macedo JO; Marchi S; da Silva CL; Chagas-Junior AD; McBride AJ; McBride FW; Reis MG; Athanazio DA. 2011. Attenuated Nephritis in Inducible Nitric Oxide Synthase Knockout C57BL/6 Mice and Pulmonary Hemorrhage in CB17 SCID and Recombination Activating Gene 1 Knockout C57BL/6 Mice Infected with Leptospira interrogans. Infect Immun 79(7):2936-40. [PubMed: 21576342]  [MGI Ref ID J:173478]

Bandi S; Joseph B; Berishvili E; Singhania R; Wu YM; Cheng K; Gupta S. 2011. Perturbations in ataxia telangiectasia mutant signaling pathways after drug-induced acute liver failure and their reversal during rescue of animals by cell therapy. Am J Pathol 178(1):161-74. [PubMed: 21224054]  [MGI Ref ID J:168235]

Banerjee P; Tripp A; Lairmore MD; Crawford L; Sieburg M; Ramos JC; Harrington W Jr; Beilke MA; Feuer G. 2010. Adult T-cell leukemia/lymphoma development in HTLV-1-infected humanized SCID mice. Blood 115(13):2640-8. [PubMed: 20124219]  [MGI Ref ID J:162610]

Banga SS; Hall KT; Sandhu AK; Weaver DT; Athwal RS. 1994. Complementation of V(D)J recombination defect and X-ray sensitivity of scid mouse cells by human chromosome 8. Mutat Res 315(3):239-47. [PubMed: 7526201]  [MGI Ref ID J:21219]

Banuelos SJ; Shultz LD; Greiner DL; Burzenski LM; Gott B; Lyons BL; Rossini AA; Appel MC. 2004. Rejection of human islets and human HLA-A2.1 transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD-scid and NOD-Rag1(null)Prf1(null) mice. Clin Immunol 112(3):273-83. [PubMed: 15308121]  [MGI Ref ID J:91764]

Bao L; Haas M; Pippin J; Wang Y; Miwa T; Chang A; Minto AW; Petkova M; Qiao G; Song WC; Alpers CE; Zhang J; Shankland SJ; Quigg RJ. 2009. Focal and segmental glomerulosclerosis induced in mice lacking decay-accelerating factor in T cells. J Clin Invest 119(5):1264-74. [PubMed: 19349693]  [MGI Ref ID J:149592]

Barber RC; Miccoli L; van Buul PP; Burr KL; van Duyn-Goedhart A; Angulo JF; Dubrova YE. 2004. Germline mutation rates at tandem repeat loci in DNA-repair deficient mice. Mutat Res 554(1-2):287-95. [PubMed: 15450426]  [MGI Ref ID J:93788]

Bardeesy N; Kim M; Xu J; Kim RS; Shen Q; Bosenberg MW; Wong WH; Chin L. 2005. Role of epidermal growth factor receptor signaling in RAS-driven melanoma. Mol Cell Biol 25(10):4176-88. [PubMed: 15870287]  [MGI Ref ID J:99136]

Barrette B; Hebert MA; Filali M; Lafortune K; Vallieres N; Gowing G; Julien JP; Lacroix S. 2008. Requirement of myeloid cells for axon regeneration. J Neurosci 28(38):9363-76. [PubMed: 18799670]  [MGI Ref ID J:142759]

Barroso-delJesus A; Lucena-Aguilar G; Sanchez L; Ligero G; Gutierrez-Aranda I; Menendez P. 2011. The Nodal inhibitor Lefty is negatively modulated by the microRNA miR-302 in human embryonic stem cells. FASEB J 25(5):1497-508. [PubMed: 21266536]  [MGI Ref ID J:172780]

Barthold SW; Hodzic E; Tunev S; Feng S. 2006. Antibody-mediated disease remission in the mouse model of lyme borreliosis. Infect Immun 74(8):4817-25. [PubMed: 16861670]  [MGI Ref ID J:112329]

Battaglia M; Stabilini A; Draghici E; Migliavacca B; Gregori S; Bonifacio E; Roncarolo MG. 2006. Induction of Tolerance in Type 1 Diabetes via Both CD4+CD25+ T Regulatory Cells and T Regulatory Type 1 Cells. Diabetes 55(6):1571-80. [PubMed: 16731819]  [MGI Ref ID J:111884]

Beamer WG; Shultz KL; Tennent BJ; Shultz LD. 1993. Granulosa cell tumorigenesis in genetically hypogonadal-immunodeficient mice grafted with ovaries from tumor-susceptible donors. Cancer Res 53(16):3741-6. [PubMed: 8339285]  [MGI Ref ID J:14443]

Belkaid Y; Mendez S; Lira R; Kadambi N; Milon G; Sacks D. 2000. A natural model of Leishmania major infection reveals a prolonged 'silent' phase of parasite amplification in the skin before the onset of lesion formation and immunity. J Immunol 165(2):969-77. [PubMed: 10878373]  [MGI Ref ID J:120233]

Bellani MA; Romanienko PJ; Cairatti DA; Camerini-Otero RD. 2005. SPO11 is required for sex-body formation, and Spo11 heterozygosity rescues the prophase arrest of Atm-/- spermatocytes. J Cell Sci 118(Pt 15):3233-45. [PubMed: 15998665]  [MGI Ref ID J:100203]

Bello-Irizarry SN; Wang J; Johnston CJ; Gigliotti F; Wright TW. 2014. MyD88 signaling regulates both host defense and immunopathogenesis during pneumocystis infection. J Immunol 192(1):282-92. [PubMed: 24293628]  [MGI Ref ID J:207087]

Benavente CA; McEvoy JD; Finkelstein D; Wei L; Kang G; Wang YD; Neale G; Ragsdale S; Valentine V; Bahrami A; Temirov J; Pounds S; Zhang J; Dyer MA. 2013. Cross-species genomic and epigenomic landscape of retinoblastoma. Oncotarget 4(6):844-59. [PubMed: 23765217]  [MGI Ref ID J:207640]

Benner EJ; Banerjee R; Reynolds AD; Sherman S; Pisarev VM; Tsiperson V; Nemachek C; Ciborowski P; Przedborski S; Mosley RL; Gendelman HE. 2008. Nitrated alpha-Synuclein Immunity Accelerates Degeneration of Nigral Dopaminergic Neurons. PLoS ONE 3(1):e1376. [PubMed: 18167537]  [MGI Ref ID J:131300]

Bertin A. 1992. Comparison of susceptibility of inbred and outbred infant mice to Escherichia coli heat-stable enterotoxin STa. Infect Immun 60(8):3117-21. [PubMed: 1639480]  [MGI Ref ID J:2117]

Bettini M; Castellaw AH; Lennon GP; Burton AR; Vignali DA. 2012. Prevention of autoimmune diabetes by ectopic pancreatic beta-cell expression of interleukin-35. Diabetes 61(6):1519-26. [PubMed: 22427377]  [MGI Ref ID J:196852]

Biedermann KA; Sun JR; Giaccia AJ; Tosto LM; Brown JM. 1991. scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair. Proc Natl Acad Sci U S A 88(4):1394-7. [PubMed: 1996340]  [MGI Ref ID J:89590]

Billerbeck E; Horwitz JA; Labitt RN; Donovan BM; Vega K; Budell WC; Koo GC; Rice CM; Ploss A. 2013. Characterization of human antiviral adaptive immune responses during hepatotropic virus infection in HLA-transgenic human immune system mice. J Immunol 191(4):1753-64. [PubMed: 23833235]  [MGI Ref ID J:205706]

Binder GK; Griffin DE. 2001. Interferon-gamma-mediated site-specific clearance of alphavirus from CNS neurons. Science 293(5528):303-6. [PubMed: 11452126]  [MGI Ref ID J:125465]

Bitsaktsis C; Huntington J; Winslow G. 2004. Production of IFN-gamma by CD4 T cells is essential for resolving ehrlichia infection. J Immunol 172(11):6894-901. [PubMed: 15153508]  [MGI Ref ID J:90518]

Blanc L; Ciciotte SL; Gwynn B; Hildick-Smith GJ; Pierce EL; Soltis KA; Cooney JD; Paw BH; Peters LL. 2012. Critical function for the Ras-GTPase activating protein RASA3 in vertebrate erythropoiesis and megakaryopoiesis. Proc Natl Acad Sci U S A 109(30):12099-104. [PubMed: 22773809]  [MGI Ref ID J:186485]

Blunt T; Gell D; Fox M; Taccioli GE; Lehmann AR; Jackson SP; Jeggo PA. 1996. Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse. Proc Natl Acad Sci U S A 93(19):10285-90. [PubMed: 8816792]  [MGI Ref ID J:35393]

Bobbala D; Chen XL; Leblanc C; Mayhue M; Stankova J; Tanaka T; Chen YG; Ilangumaran S; Ramanathan S. 2012. Interleukin-15 plays an essential role in the pathogenesis of autoimmune diabetes in the NOD mouse. Diabetologia 55(11):3010-20. [PubMed: 22890824]  [MGI Ref ID J:191833]

Boggiatto PM; Jie F; Ghosh M; Gibson-Corley KN; Ramer-Tait AE; Jones DE; Petersen CA. 2009. Altered dendritic cell phenotype in response to Leishmania amazonensis amastigote infection is mediated by MAP kinase, ERK. Am J Pathol 174(5):1818-26. [PubMed: 19349356]  [MGI Ref ID J:147971]

Bogue MA; Zhu C; Aguilar-Cordova E; Donehower LA; Roth DB. 1996. p53 is required for both radiation-induced differentiation and rescue of V(D)J rearrangement in scid mouse thymocytes. Genes Dev 10(5):553-65. [PubMed: 8598286]  [MGI Ref ID J:31868]

Boitano AE; Wang J; Romeo R; Bouchez LC; Parker AE; Sutton SE; Walker JR; Flaveny CA; Perdew GH; Denison MS; Schultz PG; Cooke MP. 2010. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science 329(5997):1345-8. [PubMed: 20688981]  [MGI Ref ID J:167433]

Boldizsar F; Tarjanyi O; Nemeth P; Mikecz K; Glant TT. 2009. Th1/Th17 polarization and acquisition of an arthritogenic phenotype in arthritis-susceptible BALB/c, but not in MHC-matched, arthritis-resistant DBA/2 mice. Int Immunol 21(5):511-22. [PubMed: 19254958]  [MGI Ref ID J:148186]

Bolz DD; Sundsbak RS; Ma Y; Akira S; Kirschning CJ; Zachary JF; Weis JH; Weis JJ. 2004. MyD88 plays a unique role in host defense but not arthritis development in Lyme disease. J Immunol 173(3):2003-10. [PubMed: 15265935]  [MGI Ref ID J:92031]

Bolz DD; Sundsbak RS; Ma Y; Akira S; Weis JH; Schwan TG; Weis JJ. 2006. Dual role of MyD88 in rapid clearance of relapsing fever Borrelia spp. Infect Immun 74(12):6750-60. [PubMed: 17030581]  [MGI Ref ID J:116070]

Bonifazi P; Zelante T; D'Angelo C; De Luca A; Moretti S; Bozza S; Perruccio K; Iannitti RG; Giovannini G; Volpi C; Fallarino F; Puccetti P; Romani L. 2009. Balancing inflammation and tolerance in vivo through dendritic cells by the commensal Candida albicans. Mucosal Immunol 2(4):362-74. [PubMed: 19421183]  [MGI Ref ID J:193381]

Bosma GC; Custer RP; Bosma MJ. 1983. A severe combined immunodeficiency mutation in the mouse. Nature 301(5900):527-30. [PubMed: 6823332]  [MGI Ref ID J:6958]

Bosma GC; Oshinsky J; Kiefer K; Nakajima PB; Charan D; Congelton C; Radic M; Bosma MJ. 2006. Development of functional B cells in a line of SCID mice with transgenes coding for anti-double-stranded DNA antibody. J Immunol 176(2):889-98. [PubMed: 16393973]  [MGI Ref ID J:126632]

Bosma M; Schuler W; Bosma G. 1988. The scid mouse mutant. Curr Top Microbiol Immunol 137:197-202. [PubMed: 3416632]  [MGI Ref ID J:9341]

Boyartchuk V; Rojas M; Yan BS; Jobe O; Hurt N; Dorfman DM; Higgins DE; Dietrich WF; Kramnik I. 2004. The host resistance locus sst1 controls innate immunity to Listeria monocytogenes infection in immunodeficient mice. J Immunol 173(8):5112-20. [PubMed: 15470055]  [MGI Ref ID J:93705]

Braumuller H; Wieder T; Brenner E; Assmann S; Hahn M; Alkhaled M; Schilbach K; Essmann F; Kneilling M; Griessinger C; Ranta F; Ullrich S; Mocikat R; Braungart K; Mehra T; Fehrenbacher B; Berdel J; Niessner H; Meier F; van den Broek M; Haring HU; Handgretinger R; Quintanilla-Martinez L; Fend F; Pesic M; Bauer J; Zender L; Schaller M; Schulze-Osthoff K; Rocken M. 2013. T-helper-1-cell cytokines drive cancer into senescence. Nature 494(7437):361-5. [PubMed: 23376950]  [MGI Ref ID J:194546]

Bregenholt S; Claesson MH. 1998. Increased intracellular Th1 cytokines in scid mice with inflammatory bowel disease. Eur J Immunol 28(1):379-89. [PubMed: 9485217]  [MGI Ref ID J:45906]

Bregenholt S; Claesson MH. 1998. Splenic T helper cell type 1 cytokine profile and extramedullary haematopoiesis in severe combined immunodeficient (scid) mice with inflammatory bowel disease (IBD). Clin Exp Immunol 111(1):166-72. [PubMed: 9472677]  [MGI Ref ID J:45450]

Brehm MA; Racki WJ; Leif J; Burzenski L; Hosur V; Wetmore A; Gott B; Herlihy M; Ignotz R; Dunn R; Shultz LD; Greiner DL. 2012. Engraftment of human HSC in non-irradiated newborn NOD-scid IL2rgammanull mice is enhanced by transgenic expression of membrane-bound human SCF. Blood :. [PubMed: 22246028]  [MGI Ref ID J:180273]

Brem-Exner BG; Sattler C; Hutchinson JA; Koehl GE; Kronenberg K; Farkas S; Inoue S; Blank C; Knechtle SJ; Schlitt HJ; Fandrich F; Geissler EK. 2008. Macrophages driven to a novel state of activation have anti-inflammatory properties in mice. J Immunol 180(1):335-49. [PubMed: 18097035]  [MGI Ref ID J:130932]

Bridgett M; Cetkovic-Cvrlje M; O'Rourke R; Shi Y; Narayanswami S; Lambert J; Ramiya V; Baekkeskov S; Leiter EH. 1998. Differential protection in two transgenic lines of NOD/Lt mice hyperexpressing the autoantigen GAD65 in pancreatic beta-cells. Diabetes 47(12):1848-56. [PubMed: 9836515]  [MGI Ref ID J:100251]

Browning JL; Allaire N; Ngam-Ek A; Notidis E; Hunt J; Perrin S; Fava RA. 2005. Lymphotoxin-beta receptor signaling is required for the homeostatic control of HEV differentiation and function. Immunity 23(5):539-50. [PubMed: 16286021]  [MGI Ref ID J:113284]

Bueno C; Lopes LF; Greaves M; Menendez P. 2007. Toward development of a novel NOD/SCID-based in vivo strategy to model multiple myeloma pathogenesis. Exp Hematol 35(10):1477-8. [PubMed: 17681665]  [MGI Ref ID J:126691]

Bugl S; Wirths S; Radsak MP; Schild H; Stein P; Andre MC; Muller MR; Malenke E; Wiesner T; Marklin M; Frick JS; Handgretinger R; Rammensee HG; Kanz L; Kopp HG. 2013. Steady-state neutrophil homeostasis is dependent on TLR4/TRIF signaling. Blood 121(5):723-33. [PubMed: 23223360]  [MGI Ref ID J:194620]

Bumgardner GL; Gao D; Li J; Baskin JH; Heininger M; Orosz CG. 2000. Rejection responses to allogeneic hepatocytes by reconstituted SCID mice, CD4, KO, and CD8 KO mice. Transplantation 70(12):1771-80. [PubMed: 11152110]  [MGI Ref ID J:66571]

Buning J; Schmitz M; Repenning B; Ludwig D; Schmidt MA; Strobel S; Zimmer KP. 2005. Interferon-gamma mediates antigen trafficking to MHC class II-positive late endosomes of enterocytes. Eur J Immunol 35(3):831-42. [PubMed: 15688349]  [MGI Ref ID J:96737]

Burdeinick-Kerr R; Wind J; Griffin DE. 2007. Synergistic roles of antibody and interferon in noncytolytic clearance of Sindbis virus from different regions of the central nervous system. J Virol 81(11):5628-36. [PubMed: 17376910]  [MGI Ref ID J:153321]

Burke SD; Barrette VF; Carter AL; Gravel J; Adams MA; Croy BA. 2011. Cardiovascular adaptations of pregnancy in T and B cell-deficient mice. Biol Reprod 85(3):605-14. [PubMed: 21613629]  [MGI Ref ID J:176701]

Burr KL; Smith AG; Dubrova YE. 2005. p53 deficiency does not affect mutation rate in the mouse germline. Oncogene 24(26):4315-8. [PubMed: 15806156]  [MGI Ref ID J:99550]

Butler JM; Nolan DJ; Vertes EL; Varnum-Finney B; Kobayashi H; Hooper AT; Seandel M; Shido K; White IA; Kobayashi M; Witte L; May C; Shawber C; Kimura Y; Kitajewski J; Rosenwaks Z; Bernstein ID; Rafii S. 2010. Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells. Cell Stem Cell 6(3):251-64. [PubMed: 20207228]  [MGI Ref ID J:158983]

Calderon B; Suri A; Unanue ER. 2006. In CD4+ T-cell-induced diabetes, macrophages are the final effector cells that mediate islet beta-cell killing: studies from an acute model. Am J Pathol 169(6):2137-47. [PubMed: 17148676]  [MGI Ref ID J:116218]

Callen E; Jankovic M; Wong N; Zha S; Chen HT; Difilippantonio S; Di Virgilio M; Heidkamp G; Alt FW; Nussenzweig A; Nussenzweig M. 2009. Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes. Mol Cell 34(3):285-97. [PubMed: 19450527]  [MGI Ref ID J:150435]

Carrero JA; Calderon B; Unanue ER. 2006. Lymphocytes are detrimental during the early innate immune response against Listeria monocytogenes. J Exp Med 203(4):933-40. [PubMed: 16549598]  [MGI Ref ID J:123753]

Carter CR; Whitcomb JP; Campbell JA; Mukbel RM; McDowell MA. 2009. Complement receptor 3 deficiency influences lesion progression during Leishmania major infection in BALB/c mice. Infect Immun 77(12):5668-75. [PubMed: 19797068]  [MGI Ref ID J:155481]

Chakraborty P; Buaas FW; Sharma M; Snyder E; de Rooij DG; Braun RE. 2014. LIN28A marks the spermatogonial progenitor population and regulates its cyclic expansion. Stem Cells 32(4):860-73. [PubMed: 24715688]  [MGI Ref ID J:210438]

Chang Y; Bosma GC; Bosma MJ. 1995. Development of B cells in scid mice with immunoglobulin transgenes: implications for the control of V(D)J recombination. Immunity 2(6):607-16. [PubMed: 7796294]  [MGI Ref ID J:27341]

Chang Y; Bosma MJ. 1997. Effect of different Ig transgenes on B cell differentiation in scid mice. Int Immunol 9(3):373-80. [PubMed: 9088976]  [MGI Ref ID J:125479]

Chaparro RJ; Konigshofer Y; Beilhack GF; Shizuru JA; McDevitt HO; Chien YH. 2006. Nonobese diabetic mice express aspects of both type 1 and type 2 diabetes. Proc Natl Acad Sci U S A 103(33):12475-80. [PubMed: 16895987]  [MGI Ref ID J:111775]

Chen CC; Murray PJ; Jiang TX; Plikus MV; Chang YT; Lee OK; Widelitz RB; Chuong CM. 2014. Regenerative hair waves in aging mice and extra-follicular modulators follistatin, dkk1, and sfrp4. J Invest Dermatol 134(8):2086-96. [PubMed: 24618599]  [MGI Ref ID J:212840]

Chen CH; Yeh YC; Wu GJ; Huang YH; Lai WF; Liu JY; Tzeng CR. 2010. Tracking the rejection and survival of mouse ovarian iso- and allografts in vivo with bioluminescent imaging. Reproduction 140(1):105-12. [PubMed: 20423932]  [MGI Ref ID J:175817]

Chen D; Pacal M; Wenzel P; Knoepfler PS; Leone G; Bremner R. 2009. Division and apoptosis of E2f-deficient retinal progenitors. Nature 462(7275):925-9. [PubMed: 20016601]  [MGI Ref ID J:155800]

Chen G; Han G; Wang J; Wang R; Xu R; Shen B; Qian J; Li Y. 2009. Natural killer cells modulate overt autoimmunity to homeostasis in nonobese diabetic mice after anti-CD3 F(ab')2 antibody treatment through secreting transforming growth factor-beta. Am J Pathol 175(3):1086-94. [PubMed: 19644014]  [MGI Ref ID J:152908]

Chen J; Chen YG; Reifsnyder PC; Schott WH; Lee CH; Osborne M; Scheuplein F; Haag F; Koch-Nolte F; Serreze DV; Leiter EH. 2006. Targeted disruption of CD38 accelerates autoimmune diabetes in NOD/Lt mice by enhancing autoimmunity in an ADP-ribosyltransferase 2-dependent fashion. J Immunol 176(8):4590-9. [PubMed: 16585549]  [MGI Ref ID J:108097]

Chen J; Gusdon AM; Piganelli J; Leiter EH; Mathews CE. 2011. mt-Nd2(a) Modifies resistance against autoimmune type 1 diabetes in NOD mice at the level of the pancreatic beta-cell. Diabetes 60(1):355-9. [PubMed: 20980458]  [MGI Ref ID J:170153]

Chen Q; Amaladoss A; Ye W; Liu M; Dummler S; Kong F; Wong LH; Loo HL; Loh E; Tan SQ; Tan TC; Chang KT; Dao M; Suresh S; Preiser PR; Chen J. 2014. Human natural killer cells control Plasmodium falciparum infection by eliminating infected red blood cells. Proc Natl Acad Sci U S A 111(4):1479-84. [PubMed: 24474774]  [MGI Ref ID J:206650]

Chen YT; Chen FY; Vijmasi T; Stephens DN; Gallup M; McNamara NA. 2013. Pax6 downregulation mediates abnormal lineage commitment of the ocular surface epithelium in aqueous-deficient dry eye disease. PLoS One 8(10):e77286. [PubMed: 24143217]  [MGI Ref ID J:209118]

Chen Z; Zhang Y; Jia C; Wang Y; Lai P; Zhou X; Wang Y; Song Q; Lin J; Ren Z; Gao Q; Zhao Z; Zheng H; Wan Z; Gao T; Zhao A; Dai Y; Bai X. 2014. mTORC1/2 targeted by n-3 polyunsaturated fatty acids in the prevention of mammary tumorigenesis and tumor progression. Oncogene 33(37):4548-57. [PubMed: 24096482]  [MGI Ref ID J:214352]

Chi X; Zhi L; Gelderman MP; Vostal JG. 2012. Host platelets and, in part, neutrophils mediate lung accumulation of transfused UVB-irradiated human platelets in a mouse model of acute lung injury. PLoS One 7(9):e44829. [PubMed: 23028636]  [MGI Ref ID J:191794]

Chiang EY; Stroynowski I. 2004. A nonclassical MHC class I molecule restricts CTL-mediated rejection of a syngeneic melanoma tumor. J Immunol 173(7):4394-401. [PubMed: 15383569]  [MGI Ref ID J:93729]

Chiaraviglio L; Duong S; Brown DA; Birtles RJ; Kirby JE. 2010. An immunocompromised murine model of chronic Bartonella infection. Am J Pathol 176(6):2753-63. [PubMed: 20395436]  [MGI Ref ID J:161161]

Chirieleison SM; Feduska JM; Schugar RC; Askew Y; Deasy BM. 2012. Human muscle-derived cell populations isolated by differential adhesion rates: phenotype and contribution to skeletal muscle regeneration in Mdx/SCID mice. Tissue Eng Part A 18(3-4):232-41. [PubMed: 21854253]  [MGI Ref ID J:181239]

Chiu IM; Heesters BA; Ghasemlou N; Von Hehn CA; Zhao F; Tran J; Wainger B; Strominger A; Muralidharan S; Horswill AR; Bubeck Wardenburg J; Hwang SW; Carroll MC; Woolf CJ. 2013. Bacteria activate sensory neurons that modulate pain and inflammation. Nature 501(7465):52-7. [PubMed: 23965627]  [MGI Ref ID J:205431]

Choi B; Chun E; Kim M; Kim SY; Kim ST; Yoon K; Lee KY; Kim SJ. 2011. Human T cell development in the liver of humanized NOD/SCID/IL-2Rgamma(null)(NSG) mice generated by intrahepatic injection of CD34(+) human (h) cord blood (CB) cells. Clin Immunol 139(3):321-35. [PubMed: 21429805]  [MGI Ref ID J:173961]

Chou FC; Shieh SJ; Sytwu HK. 2009. Attenuation of Th1 response through galectin-9 and T-cell Ig mucin 3 interaction inhibits autoimmune diabetes in NOD mice. Eur J Immunol 39(9):2403-11. [PubMed: 19670381]  [MGI Ref ID J:152168]

Chow LH. 1993. Studies of virus-induced myocardial injury in mice: value of the scid mutation on different genetic backgrounds and combined with other mutations. Lab Anim Sci 43(2):133-5. [PubMed: 8391609]  [MGI Ref ID J:12476]

Christianson SW; Greiner DL; Hesselton RA; Leif JH; Wagar EJ; Schweitzer IB; Rajan TV; Gott B; Roopenian DC; Shultz LD. 1997. Enhanced human CD4+ T cell engraftment in beta2-microglobulin-deficient NOD-scid mice. J Immunol 158(8):3578-86. [PubMed: 9103418]  [MGI Ref ID J:102141]

Christianson SW; Greiner DL; Schweitzer IB; Gott B; Beamer GL; Schweitzer PA; Hesselton RM; Shultz LD. 1996. Role of natural killer cells on engraftment of human lymphoid cells and on metastasis of human T-lymphoblastoid leukemia cells in C57BL/6J-scid mice and in C57BL/6J-scid bg mice. Cell Immunol 171(2):186-99. [PubMed: 8806787]  [MGI Ref ID J:34814]

Cleveland SM; Smith S; Tripathi R; Mathias EM; Goodings C; Elliott N; Peng D; El-Rifai W; Yi D; Chen X; Li L; Mullighan C; Downing JR; Love P; Dave UP. 2013. Lmo2 induces hematopoietic stem cell-like features in T-cell progenitor cells prior to leukemia. Stem Cells 31(5):882-94. [PubMed: 23378057]  [MGI Ref ID J:196312]

Cook AJ; Oganesian L; Harumal P; Basten A; Brink R; Jolly CJ. 2003. Reduced switching in SCID B cells is associated with altered somatic mutation of recombined S regions. J Immunol 171(12):6556-64. [PubMed: 14662857]  [MGI Ref ID J:117994]

Coombes JL; Siddiqui KR; Arancibia-Carcamo CV; Hall J; Sun CM; Belkaid Y; Powrie F. 2007. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med 204(8):1757-64. [PubMed: 17620361]  [MGI Ref ID J:203901]

Coppola V; Barrick CA; Southon EA; Celeste A; Wang K; Chen B; Haddad el-B; Yin J; Nussenzweig A; Subramaniam A; Tessarollo L. 2004. Ablation of TrkA function in the immune system causes B cell abnormalities. Development 131(20):5185-95. [PubMed: 15459109]  [MGI Ref ID J:93578]

Covassin L; Jangalwe S; Jouvet N; Laning J; Burzenski L; Shultz LD; Brehm MA. 2013. Human immune system development and survival of NOD-scid IL2rgamma (NSG) mice engrafted with human thymus and autologous hematopoietic stem cells. Clin Exp Immunol :. [PubMed: 23869841]  [MGI Ref ID J:200896]

Covassin L; Laning J; Abdi R; Langevin DL; Phillips NE; Shultz LD; Brehm MA. 2011. Human peripheral blood CD4 T cell-engrafted non-obese diabetic-scid IL2rgamma(null) H2-Ab1 (tm1Gru) Tg (human leucocyte antigen D-related 4) mice: a mouse model of human allogeneic graft-versus-host disease. Clin Exp Immunol 166(2):269-80. [PubMed: 21985373]  [MGI Ref ID J:177904]

Craven AJ; Nixon AJ; Ashby MG; Ormandy CJ; Blazek K; Wilkins RJ; Pearson AJ. 2006. Prolactin delays hair regrowth in mice. J Endocrinol 191(2):415-25. [PubMed: 17088411]  [MGI Ref ID J:114701]

Crowe MJ; Doetschman T; Greenhalgh DG. 2000. Delayed wound healing in immunodeficient TGF-beta1 knockout mice J Invest Dermatol 115(1):3-11. [PubMed: 10886500]  [MGI Ref ID J:63260]

Crowley SD; Song YS; Lin EE; Griffiths R; Kim HS; Ruiz P. 2010. Lymphocyte responses exacerbate angiotensin II-dependent hypertension. Am J Physiol Regul Integr Comp Physiol 298(4):R1089-97. [PubMed: 20147609]  [MGI Ref ID J:158609]

Culmsee C; Bondada S; Mattson MP. 2001. Hippocampal neurons of mice deficient in DNA-dependent protein kinase exhibit increased vulnerability to DNA damage, oxidative stress and excitotoxicity. Brain Res Mol Brain Res 87(2):257-62. [PubMed: 11245929]  [MGI Ref ID J:109293]

Cupedo T; Lund FE; Ngo VN; Randall TD; Jansen W; Greuter MJ; de Waal-Malefyt R; Kraal G; Cyster JG; Mebius RE. 2004. Initiation of cellular organization in lymph nodes is regulated by non-B cell-derived signals and is not dependent on CXC chemokine ligand 13. J Immunol 173(8):4889-96. [PubMed: 15470030]  [MGI Ref ID J:93711]

Custer RP; Bosma GC; Bosma MJ. 1985. Severe combined immunodeficiency (SCID) in the mouse. Pathology, reconstitution, neoplasms. Am J Pathol 120(3):464-77. [PubMed: 2412448]  [MGI Ref ID J:30980]

Dann SM; Spehlmann ME; Hammond DC; Iimura M; Hase K; Choi LJ; Hanson E; Eckmann L. 2008. IL-6-dependent mucosal protection prevents establishment of a microbial niche for attaching/effacing lesion-forming enteric bacterial pathogens. J Immunol 180(10):6816-26. [PubMed: 18453602]  [MGI Ref ID J:134871]

Danska JS; Holland DP; Mariathasan S; Williams KM; Guidos CJ. 1996. Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes. Mol Cell Biol 16(10):5507-17. [PubMed: 8816463]  [MGI Ref ID J:35350]

Darwiche R; Chong MM; Santamaria P; Thomas HE; Kay TW. 2003. Fas is detectable on beta cells in accelerated, but not spontaneous, diabetes in nonobese diabetic mice. J Immunol 170(12):6292-7. [PubMed: 12794162]  [MGI Ref ID J:108698]

Das R; Bassiri H; Guan P; Wiener S; Banerjee PP; Zhong MC; Veillette A; Orange JS; Nichols KE. 2013. The adaptor molecule SAP plays essential roles during invariant NKT cell cytotoxicity and lytic synapse formation. Blood 121(17):3386-95. [PubMed: 23430111]  [MGI Ref ID J:196692]

De Luca A; Carvalho A; Cunha C; Iannitti RG; Pitzurra L; Giovannini G; Mencacci A; Bartolommei L; Moretti S; Massi-Benedetti C; Fuchs D; De Bernardis F; Puccetti P; Romani L. 2013. IL-22 and IDO1 affect immunity and tolerance to murine and human vaginal candidiasis. PLoS Pathog 9(7):e1003486. [PubMed: 23853597]  [MGI Ref ID J:213365]

De Palma M; Venneri MA; Galli R; Sergi LS; Politi LS; Sampaolesi M; Naldini L. 2005. Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors. Cancer Cell 8(3):211-26. [PubMed: 16169466]  [MGI Ref ID J:102241]

Derecki NC; Cardani AN; Yang CH; Quinnies KM; Crihfield A; Lynch KR; Kipnis J. 2010. Regulation of learning and memory by meningeal immunity: a key role for IL-4. J Exp Med 207(5):1067-80. [PubMed: 20439540]  [MGI Ref ID J:160932]

DiLorenzo TP; Lieberman SM; Takaki T; Honda S; Chapman HD; Santamaria P; Serreze DV; Nathenson SG. 2002. During the early prediabetic period in NOD mice, the pathogenic CD8(+) T-cell population comprises multiple antigenic specificities. Clin Immunol 105(3):332-41. [PubMed: 12498815]  [MGI Ref ID J:94192]

Diamond RA; Ward SB; Owada-Makabe K; Wang H; Rothenberg EV. 1997. Different developmental arrest points in RAG-2 -/- and SCID thymocytes on two genetic backgrounds: developmental choices and cell death mechanisms before TCR gene rearrangement. J Immunol 158(9):4052-64. [PubMed: 9126963]  [MGI Ref ID J:39793]

Diaz-Manera J; Touvier T; Dellavalle A; Tonlorenzi R; Tedesco FS; Messina G; Meregalli M; Navarro C; Perani L; Bonfanti C; Illa I; Torrente Y; Cossu G. 2010. Partial dysferlin reconstitution by adult murine mesoangioblasts is sufficient for full functional recovery in a murine model of dysferlinopathy. Cell Death Dis 1:e61. [PubMed: 21364666]  [MGI Ref ID J:186461]

Dibra D; Cutrera JJ; Li S. 2012. Coordination between TLR9 signaling in macrophages and CD3 signaling in T cells induces robust expression of IL-30. J Immunol 188(8):3709-15. [PubMed: 22407920]  [MGI Ref ID J:184078]

Dodig TD; Mack KT; Cassarino DF; Clark SH. 2001. Development of the tight-skin phenotype in immune-deficient mice. Arthritis Rheum 44(3):723-7. [PubMed: 11263788]  [MGI Ref ID J:112962]

Doherty TM; Sher A. 1997. Defects in cell-mediated immunity affect chronic, but not innate, resistance of mice to Mycobacterium avium infection. J Immunol 158(10):4822-31. [PubMed: 9144497]  [MGI Ref ID J:40202]

Dohi T; Fujihashi K; Koga T; Etani Y; Yoshino N; Kawamura YI; McGhee JR. 2004. CD4+CD45RBHi interleukin-4 defective T cells elicit antral gastritis and duodenitis. Am J Pathol 165(4):1257-68. [PubMed: 15466391]  [MGI Ref ID J:93676]

Dohi T; Fujihashi K; Koga T; Shirai Y; Kawamura YI; Ejima C; Kato R; Saitoh K; McGhee JR. 2003. T helper type-2 cells induce ileal villus atrophy, goblet cell metaplasia, and wasting disease in T cell-deficient mice. Gastroenterology 124(3):672-82. [PubMed: 12612906]  [MGI Ref ID J:82106]

Dominique V; Francis L. 1995. Interactions of the scid or beige mutations with the viable motheaten mutation. Autoimmunity 22(4):199-207. [PubMed: 8781712]  [MGI Ref ID J:33985]

Dorshkind K; Keller GM; Phillips RA; Miller RG; Bosma GC; O'Toole M; Bosma MJ. 1984. Functional status of cells from lymphoid and myeloid tissues in mice with severe combined immunodeficiency disease. J Immunol 132(4):1804-8. [PubMed: 6607948]  [MGI Ref ID J:7343]

Dos Santos C; McDonald T; Ho YW; Liu H; Lin A; Forman SJ; Kuo YH; Bhatia R. 2013. The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agents. Blood 122(11):1900-13. [PubMed: 23896410]  [MGI Ref ID J:202360]

Dreyer AM; Matile H; Papastogiannidis P; Kamber J; Favuzza P; Voss TS; Wittlin S; Pluschke G. 2012. Passive immunoprotection of Plasmodium falciparum-infected mice designates the CyRPA as candidate malaria vaccine antigen. J Immunol 188(12):6225-37. [PubMed: 22593616]  [MGI Ref ID J:188965]

Dudek NL; Thomas HE; Mariana L; Sutherland RM; Allison J; Estella E; Angstetra E; Trapani JA; Santamaria P; Lew AM; Kay TW. 2006. Cytotoxic T-cells from T-cell receptor transgenic NOD8.3 mice destroy beta-cells via the perforin and Fas pathways. Diabetes 55(9):2412-8. [PubMed: 16936188]  [MGI Ref ID J:116592]

Dudley ME; Sundberg JP; Roopenian DC. 1996. Frequency and histological appearance of adenomas in multiple intestinal neoplasia mice are unaffected by severe combined immunodeficiency (scid) mutation. Int J Cancer 65(2):249-53. [PubMed: 8567125]  [MGI Ref ID J:31690]

Dullin C; Missbach-Guentner J; Vogel WF; Grabbe E; Alves F. 2007. Semi-Automatic Classification of Skeletal Morphology in Genetically Altered Mice Using Flat-Panel Volume Computed Tomography. PLoS Genet 3(7):e118. [PubMed: 17658952]  [MGI Ref ID J:123719]

Dumont N; Boyer L; Emond H; Celebi-Saltik B; Pasha R; Bazin R; Mantovani D; Roy DC; Pineault N. 2014. Medium conditioned with mesenchymal stromal cell-derived osteoblasts improves the expansion and engraftment properties of cord blood progenitors. Exp Hematol 42(9):741-752.e1. [PubMed: 24793546]  [MGI Ref ID J:214003]

Eaton KA; Benson LH; Haeger J; Gray BM. 2006. Role of transcription factor T-bet expression by CD4+ cells in gastritis due to Helicobacter pylori in mice. Infect Immun 74(8):4673-84. [PubMed: 16861655]  [MGI Ref ID J:112403]

Eaton KA; Mefford M; Thevenot T. 2001. The role of T cell subsets and cytokines in the pathogenesis of Helicobacter pylori gastritis in mice. J Immunol 166(12):7456-61. [PubMed: 11390498]  [MGI Ref ID J:124425]

Ebrahem Q; Chaurasia SS; Vasanji A; Qi JH; Klenotic PA; Cutler A; Asosingh K; Erzurum S; Anand-Apte B. 2010. Cross-talk between vascular endothelial growth factor and matrix metalloproteinases in the induction of neovascularization in vivo. Am J Pathol 176(1):496-503. [PubMed: 19948826]  [MGI Ref ID J:156380]

Economopoulos V; Noad JC; Krishnamoorthy S; Rutt BK; Foster PJ. 2011. Comparing the MRI appearance of the lymph nodes and spleen in wild-type and immuno-deficient mouse strains. PLoS One 6(11):e27508. [PubMed: 22096586]  [MGI Ref ID J:180968]

Emoto M; Mittrucker HW; Schmits R; Mak TW; Kaufmann SH. 1999. Critical role of leukocyte function-associated antigen-1 in liver accumulation of CD4+NKT cells. J Immunol 162(9):5094-8. [PubMed: 10227978]  [MGI Ref ID J:111009]

Engle SJ; Ormsby I; Pawlowski S; Boivin GP; Croft J; Balish E; Doetschman T. 2002. Elimination of Colon Cancer in Germ-free Transforming Growth Factor Beta 1-deficient Mice. Cancer Res 62(22):6362-6. [PubMed: 12438215]  [MGI Ref ID J:80209]

Ernst PB; Erickson LD; Loo WM; Scott KG; Wiznerowicz EB; Brown CC; Torres-Velez FJ; Alam MS; Black SG; McDuffie M; Feldman SH; Wallace JL; McKnight GW; Padol IT; Hunt RH; Tung KS. 2012. Spontaneous autoimmune gastritis and hypochlorhydria are manifest in the ileitis-prone SAMP1/YitFcs mice. Am J Physiol Gastrointest Liver Physiol 302(1):G105-15. [PubMed: 21921286]  [MGI Ref ID J:183342]

Eyob H; Ekiz HA; Derose YS; Waltz SE; Williams MA; Welm AL. 2013. Inhibition of ron kinase blocks conversion of micrometastases to overt metastases by boosting antitumor immunity. Cancer Discov 3(7):751-60. [PubMed: 23612011]  [MGI Ref ID J:203569]

Fahlen L; Read S; Gorelik L; Hurst SD; Coffman RL; Flavell RA; Powrie F. 2005. T cells that cannot respond to TGF-{beta} escape control by CD4+CD25+ regulatory T cells. J Exp Med 201(5):737-46. [PubMed: 15753207]  [MGI Ref ID J:96624]

Faleo G; Fotino C; Bocca N; Molano RD; Zahr-Akrawi E; Molina J; Villate S; Umland O; Skyler JS; Bayer AL; Ricordi C; Pileggi A. 2012. Prevention of autoimmune diabetes and induction of beta-cell proliferation in NOD mice by hyperbaric oxygen therapy. Diabetes 61(7):1769-78. [PubMed: 22566533]  [MGI Ref ID J:203601]

Fang R; Ismail N; Walker DH. 2012. Contribution of NK cells to the innate phase of host protection against an intracellular bacterium targeting systemic endothelium. Am J Pathol 181(1):185-95. [PubMed: 22617213]  [MGI Ref ID J:185539]

Farini A; Meregalli M; Belicchi M; Battistelli M; Parolini D; D'Antona G; Gavina M; Ottoboni L; Constantin G; Bottinelli R; Torrente Y. 2007. T and B lymphocyte depletion has a marked effect on the fibrosis of dystrophic skeletal muscles in the scid/mdx mouse. J Pathol 213(2):229-38. [PubMed: 17668421]  [MGI Ref ID J:125527]

Farini A; Sitzia C; Navarro C; D'Antona G; Belicchi M; Parolini D; Del Fraro G; Razini P; Bottinelli R; Meregalli M; Torrente Y. 2012. Absence of T and B lymphocytes modulates dystrophic features in dysferlin deficient animal model. Exp Cell Res 318(10):1160-74. [PubMed: 22465227]  [MGI Ref ID J:186460]

Feng M; Chen JY; Weissman-Tsukamoto R; Volkmer JP; Ho PY; McKenna KM; Cheshier S; Zhang M; Guo N; Gip P; Mitra SS; Weissman IL. 2015. Macrophages eat cancer cells using their own calreticulin as a guide: roles of TLR and Btk. Proc Natl Acad Sci U S A 112(7):2145-50. [PubMed: 25646432]  [MGI Ref ID J:220007]

Fernandez NC; Lozier A; Flament C; Ricciardi-Castagnoli P; Bellet D; Suter M; Perricaudet M; Tursz T; Maraskovsky E; Zitvogel L. 1999. Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivo. Nat Med 5(4):405-11. [PubMed: 10202929]  [MGI Ref ID J:54135]

Fiorucci S; Mencarelli A; Palazzetti B; Sprague AG; Distrutti E; Morelli A; Novobrantseva TI; Cirino G; Koteliansky VE; de Fougerolles AR. 2002. Importance of innate immunity and collagen binding integrin alpha1beta1 in TNBS-induced colitis. Immunity 17(6):769-80. [PubMed: 12479823]  [MGI Ref ID J:113581]

Flanagan K; Modrusan Z; Cornelius J; Chavali A; Kasman I; Komuves L; Mo L; Diehl L. 2008. Intestinal Epithelial Cell Up-Regulation of LY6 Molecules during Colitis Results in Enhanced Chemokine Secretion. J Immunol 180(6):3874-81. [PubMed: 18322195]  [MGI Ref ID J:133031]

Flesken-Nikitin A; Hwang CI; Cheng CY; Michurina TV; Enikolopov G; Nikitin AY. 2013. Ovarian surface epithelium at the junction area contains a cancer-prone stem cell niche. Nature 495(7440):241-5. [PubMed: 23467088]  [MGI Ref ID J:194916]

Fogler WE; Volker K; Watanabe M; Wigginton JM; Roessler P; Brunda MJ; Ortaldo JR; Wiltrout RH. 1998. Recruitment of hepatic NK cells by IL-12 is dependent on IFN-gamma and VCAM-1 and is rapidly down-regulated by a mechanism involving T cells and expression of Fas. J Immunol 161(11):6014-21. [PubMed: 9834083]  [MGI Ref ID J:115033]

Foquet L; Hermsen CC; van Gemert GJ; Van Braeckel E; Weening KE; Sauerwein R; Meuleman P; Leroux-Roels G. 2014. Vaccine-induced monoclonal antibodies targeting circumsporozoite protein prevent Plasmodium falciparum infection. J Clin Invest 124(1):140-4. [PubMed: 24292709]  [MGI Ref ID J:207925]

Forbes JM; Soderlund J; Yap FY; Knip M; Andrikopoulos S; Ilonen J; Simell O; Veijola R; Sourris KC; Coughlan MT; Forsblom C; Slattery R; Grey ST; Wessman M; Yamamoto H; Bierhaus A; Cooper ME; Groop PH. 2011. Receptor for advanced glycation end-products (RAGE) provides a link between genetic susceptibility and environmental factors in type 1 diabetes. Diabetologia :. [PubMed: 21298413]  [MGI Ref ID J:169600]

Ford ML; Evavold BD. 2006. Modulation of MOG 37-50-specific CD8+ T cell activation and expansion by CD43. Cell Immunol 240(1):53-61. [PubMed: 16890924]  [MGI Ref ID J:112761]

Fortner KA; Lees RK; Macdonald HR; Budd RC. 2011. Fas (CD95/APO-1) limits the expansion of T lymphocytes in an environment of limited T-cell antigen receptor/MHC contacts. Int Immunol 23(2):75-88. [PubMed: 21266499]  [MGI Ref ID J:168554]

Fournier B; Murray B; Gutzwiller S; Marcaletti S; Marcellin D; Bergling S; Brachat S; Persohn E; Pierrel E; Bombard F; Hatakeyama S; Trendelenburg AU; Morvan F; Richardson B; Glass DJ; Lach-Trifilieff E; Feige JN. 2012. Blockade of the activin receptor IIb activates functional brown adipogenesis and thermogenesis by inducing mitochondrial oxidative metabolism. Mol Cell Biol 32(14):2871-9. [PubMed: 22586266]  [MGI Ref ID J:186659]

Franco S; Murphy MM; Li G; Borjeson T; Boboila C; Alt FW. 2008. DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination. J Exp Med 205(3):557-64. [PubMed: 18316419]  [MGI Ref ID J:133132]

Frese M; Lee E; Larena M; Lim PS; Rao S; Matthaei KI; Khromykh A; Ramshaw I; Lobigs M. 2014. Internal ribosome entry site-based attenuation of a flavivirus candidate vaccine and evaluation of the effect of Beta interferon coexpression on vaccine properties. J Virol 88(4):2056-70. [PubMed: 24307589]  [MGI Ref ID J:205265]

Friswell MK; Gika H; Stratford IJ; Theodoridis G; Telfer B; Wilson ID; McBain AJ. 2010. Site and strain-specific variation in gut microbiota profiles and metabolism in experimental mice. PLoS One 5(1):e8584. [PubMed: 20052418]  [MGI Ref ID J:157249]

Fukunaga-Kalabis M; Martinez G; Nguyen TK; Kim D; Santiago-Walker A; Roesch A; Herlyn M. 2010. Tenascin-C promotes melanoma progression by maintaining the ABCB5-positive side population. Oncogene 29(46):6115-24. [PubMed: 20729912]  [MGI Ref ID J:166563]

Fulop GM; Phillips RA. 1986. Full reconstitution of the immune deficiency in scid mice with normal stem cells requires low-dose irradiation of the recipients. J Immunol 136(12):4438-43. [PubMed: 3519770]  [MGI Ref ID J:8299]

Fyfe AI; Qiao JH; Lusis AJ. 1994. Immune-deficient mice develop typical atherosclerotic fatty streaks when fed an atherogenic diet. J Clin Invest 94(6):2516-20. [PubMed: 7989611]  [MGI Ref ID J:22138]

Gallo-Hendrikx E; Percy D; Copps J; McKeown B; Quinton M; McMillan I; Croy BA; Wildeman AG. 1999. Evaluation of three lines of immunodeficient mice for the study of spontaneous metastatic tumors. APMIS 107(2):245-56. [PubMed: 10225324]  [MGI Ref ID J:54114]

Ganley L; Babu S; Rajan TV. 2001. Course of Brugia malayi infection in C57BL/6J NOS2 +/+ and -/- mice. Exp Parasitol 98(1):35-43. [PubMed: 11426950]  [MGI Ref ID J:102684]

Garcia-Barros M; Thin TH; Maj J; Cordon-Cardo C; Haimovitz-Friedman A; Fuks Z; Kolesnick R. 2010. Impact of stromal sensitivity on radiation response of tumors implanted in SCID hosts revisited. Cancer Res 70(20):8179-86. [PubMed: 20924105]  [MGI Ref ID J:165564]

Garcia-Rivera MF; Colvin-Wanshura LE; Nelson MS; Nan Z; Khan SA; Rogers TB; Maitra I; Low WC; Gupta P. 2007. Characterization of an immunodeficient mouse model of mucopolysaccharidosis type I suitable for preclinical testing of human stem cell and gene therapy. Brain Res Bull 74(6):429-38. [PubMed: 17920451]  [MGI Ref ID J:139626]

Gawronska-Kozak B; Bogacki M; Rim JS; Monroe WT; Manuel JA. 2006. Scarless skin repair in immunodeficient mice. Wound Repair Regen 14(3):265-76. [PubMed: 16808805]  [MGI Ref ID J:135709]

Gelman AE; LaRosa DF; Zhang J; Walsh PT; Choi Y; Sunyer JO; Turka LA. 2006. The adaptor molecule MyD88 activates PI-3 kinase signaling in CD4+ T cells and enables CpG oligodeoxynucleotide-mediated costimulation. Immunity 25(5):783-93. [PubMed: 17055754]  [MGI Ref ID J:116106]

Gerling IC; Friedman H; Greiner DL; Shultz LD; Leiter EH. 1994. Multiple low-dose streptozocin-induced diabetes in NOD-scid/scid mice in the absence of functional lymphocytes. Diabetes 43(3):433-40. [PubMed: 8314017]  [MGI Ref ID J:16998]

Gesina E; Blondeau B; Milet A; Le Nin I; Duchene B; Czernichow P; Scharfmann R; Tronche F; Breant B. 2006. Glucocorticoid signalling affects pancreatic development through both direct and indirect effects. Diabetologia 49(12):2939-47. [PubMed: 17001468]  [MGI Ref ID J:147261]

Gittens JE; Barr KJ; Vanderhyden BC; Kidder GM. 2005. Interplay between paracrine signaling and gap junctional communication in ovarian follicles. J Cell Sci 118(Pt 1):113-22. [PubMed: 15585573]  [MGI Ref ID J:94692]

Gladdy RA; Nutter LM; Kunath T; Danska JS; Guidos CJ. 2006. p53-Independent apoptosis disrupts early organogenesis in embryos lacking both ataxia-telangiectasia mutated and Prkdc. Mol Cancer Res 4(5):311-8. [PubMed: 16687486]  [MGI Ref ID J:108789]

Gladdy RA; Taylor MD; Williams CJ; Grandal I; Karaskova J; Squire JA; Rutka JT; Guidos CJ; Danska JS. 2003. The RAG-1/2 endonuclease causes genomic instability and controls CNS complications of lymphoblastic leukemia in p53/Prkdc-deficient mice. Cancer Cell 3(1):37-50. [PubMed: 12559174]  [MGI Ref ID J:81538]

Glimm H; Eisterer W; Lee K; Cashman J; Holyoake TL; Nicolini F; Shultz LD; von Kalle C; Eaves CJ. 2001. Previously undetected human hematopoietic cell populations with short-term repopulating activity selectively engraft NOD/SCID-beta2 microglobulin-null mice. J Clin Invest 107(2):199-206. [PubMed: 11160136]  [MGI Ref ID J:66974]

Goldstein AS; Huang J; Guo C; Garraway IP; Witte ON. 2010. Identification of a cell of origin for human prostate cancer. Science 329(5991):568-71. [PubMed: 20671189]  [MGI Ref ID J:162606]

Gorantla S; Makarov E; Finke-Dwyer J; Gebhart CL; Domm W; Dewhurst S; Gendelman HE; Poluektova LY. 2010. CD8+ cell depletion accelerates HIV-1 immunopathology in humanized mice. J Immunol 184(12):7082-91. [PubMed: 20495069]  [MGI Ref ID J:161304]

Graff RJ. 1970. Polymorphism of histocompatibility genes in the mouse. Transplant Proc 2(1):15-23. [PubMed: 4107291]  [MGI Ref ID J:5237]

Graser RT; DiLorenzo TP; Wang F; Christianson GJ; Chapman HD; Roopenian DC; Nathenson SG; Serreze DV. 2000. Identification of a CD8 T cell that can independently mediate autoimmune diabetes development in the complete absence of CD4 T cell helper functions. J Immunol 164(7):3913-8. [PubMed: 10725754]  [MGI Ref ID J:93553]

Gray CA; Lawrence RA. 2002. A role for antibody and Fc receptor in the clearance of Brugia malayi microfilariae. Eur J Immunol 32(4):1114-20. [PubMed: 11920579]  [MGI Ref ID J:115364]

Green-Mitchell SM; Tersey SA; Cole BK; Ma K; Kuhn NS; Cunningham TD; Maybee NA; Chakrabarti SK; McDuffie M; Taylor-Fishwick DA; Mirmira RG; Nadler JL; Morris MA. 2013. Deletion of 12/15-lipoxygenase alters macrophage and islet function in NOD-Alox15(null) mice, leading to protection against type 1 diabetes development. PLoS One 8(2):e56763. [PubMed: 23437231]  [MGI Ref ID J:197192]

Grenningloh R; Kang BY; Ho IC. 2005. Ets-1, a functional cofactor of T-bet, is essential for Th1 inflammatory responses. J Exp Med 201(4):615-26. [PubMed: 15728239]  [MGI Ref ID J:96627]

Guay HM; Andreyeva TA; Garcea RL; Welsh RM; Szomolanyi-Tsuda E. 2007. MyD88 is required for the formation of long-term humoral immunity to virus infection. J Immunol 178(8):5124-31. [PubMed: 17404295]  [MGI Ref ID J:145278]

Guay HM; Panarey L; Reed AJ; Caton AJ. 2004. Specificity-based negative selection of autoreactive B cells during memory formation. J Immunol 173(9):5485-94. [PubMed: 15494496]  [MGI Ref ID J:93744]

Guidos CJ; Williams CJ; Grandal I; Knowles G; Huang MT; Danska JS. 1996. V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors. Genes Dev 10(16):2038-54. [PubMed: 8769647]  [MGI Ref ID J:102044]

Gurley KE; Kemp CJ. 2001. Synthetic lethality between mutation in Atm and DNA-PK(cs) during murine embryogenesis. Curr Biol 11(3):191-4. [PubMed: 11231155]  [MGI Ref ID J:67533]

Gurley KE; Vo K; Kemp CJ. 1998. DNA double-strand breaks, p53, and apoptosis during lymphomagenesis in scid/scid mice. Cancer Res 58(14):3111-5. [PubMed: 9679979]  [MGI Ref ID J:49372]

Haks MC; Belkowski SM; Ciofani M; Rhodes M; Lefebvre JM; Trop S; Hugo P; Zuniga-Pflucker JC; Wiest DL. 2003. Low activation threshold as a mechanism for ligand-independent signaling in pre-T cells. J Immunol 170(6):2853-61. [PubMed: 12626535]  [MGI Ref ID J:126301]

Haks MC; Krimpenfort P; van den Brakel JH; Kruisbeek AM. 1999. Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells. Immunity 11(1):91-101. [PubMed: 10435582]  [MGI Ref ID J:110456]

Halim TY; Maclaren A; Romanish MT; Gold MJ; McNagny KM; Takei F. 2012. Retinoic-Acid-receptor-related orphan nuclear receptor alpha is required for natural helper cell development and allergic inflammation. Immunity 37(3):463-74. [PubMed: 22981535]  [MGI Ref ID J:187662]

Halin C; Tobler NE; Vigl B; Brown LF; Detmar M. 2007. VEGF-A produced by chronically inflamed tissue induces lymphangiogenesis in draining lymph nodes. Blood 110(9):3158-67. [PubMed: 17625067]  [MGI Ref ID J:148904]

Haller BL; Barkon ML; Vogler GP; Virgin HW 4th. 1995. Genetic mapping of reovirus virulence and organ tropism in severe combined immunodeficient mice: organ-specific virulence genes. J Virol 69(1):357-64. [PubMed: 7983730]  [MGI Ref ID J:21933]

Han D; Walsh MC; Cejas PJ; Dang NN; Kim YF; Kim J; Charrier-Hisamuddin L; Chau L; Zhang Q; Bittinger K; Bushman FD; Turka LA; Shen H; Reizis B; Defranco AL; Wu GD; Choi Y. 2013. Dendritic cell expression of the signaling molecule TRAF6 is critical for gut microbiota-dependent immune tolerance. Immunity 38(6):1211-22. [PubMed: 23791643]  [MGI Ref ID J:207581]

Hande P; Slijepcevic P; Silver A; Bouffler S; van Buul P; Bryant P ; Lansdorp P. 1999. Elongated telomeres in scid mice. Genomics 56(2):221-3. [PubMed: 10051409]  [MGI Ref ID J:53579]

Hanks BA; Holtzhausen A; Evans KS; Jamieson R; Gimpel P; Campbell OM; Hector-Greene M; Sun L; Tewari A; George A; Starr M; Nixon A; Augustine C; Beasley G; Tyler DS; Osada T; Morse MA; Ling L; Lyerly HK; Blobe GC. 2013. Type III TGF-beta receptor downregulation generates an immunotolerant tumor microenvironment. J Clin Invest 123(9):3925-40. [PubMed: 23925295]  [MGI Ref ID J:201617]

Harkness RE; Guimond MJ; McBey BA; Klein MH; Percy DH; Croy BA. 1993. Branhamella catarrhalis pathogenesis in SCID and SCID/beige mice. Brief report. APMIS 101(10):805-10. [PubMed: 8267959]  [MGI Ref ID J:16050]

Harris WJ; Huang X; Lynch JT; Spencer GJ; Hitchin JR; Li Y; Ciceri F; Blaser JG; Greystoke BF; Jordan AM; Miller CJ; Ogilvie DJ; Somervaille TC. 2012. The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells. Cancer Cell 21(4):473-87. [PubMed: 22464800]  [MGI Ref ID J:189339]

Hasegawa M; Kawai K; Mitsui T; Taniguchi K; Monnai M; Wakui M; Ito M; Suematsu M; Peltz G; Nakamura M; Suemizu H. 2011. The reconstituted 'humanized liver' in TK-NOG mice is mature and functional. Biochem Biophys Res Commun 405(3):405-10. [PubMed: 21238430]  [MGI Ref ID J:170638]

Hastey CJ; Elsner RA; Barthold SW; Baumgarth N. 2012. Delays and diversions mark the development of B cell responses to Borrelia burgdorferi infection. J Immunol 188(11):5612-22. [PubMed: 22547698]  [MGI Ref ID J:188726]

Hayashi Y; Haneji N; Hamano H; Yanagi K. 1994. Transfer of Sjogren's syndrome-like autoimmune lesions into SCID mice and prevention of lesions by anti-CD4 and anti-T cell receptor antibody treatment. Eur J Immunol 24(11):2826-31. [PubMed: 7957574]  [MGI Ref ID J:21965]

Hayward AR; Chmura K; Cosyns M. 2000. Interferon-gamma is required for innate immunity to Cryptosporidium parvum in mice. J Infect Dis 182(3):1001-4. [PubMed: 10950807]  [MGI Ref ID J:125986]

He J; Haskins K. 2008. Pathogenicity of T helper 2 T-cell clones from T-cell receptor transgenic non-obese diabetic mice is determined by tumour necrosis factor-alpha. Immunology 123(1):108-17. [PubMed: 17983440]  [MGI Ref ID J:134900]

He Q; Morillon YM 2nd; Spidale NA; Kroger CJ; Liu B; Sartor RB; Wang B; Tisch R. 2013. Thymic development of autoreactive T cells in NOD mice is regulated in an age-dependent manner. J Immunol 191(12):5858-66. [PubMed: 24198282]  [MGI Ref ID J:207147]

Heaney NB; Pellicano F; Zhang B; Crawford L; Chu S; Kazmi SM; Allan EK; Jorgensen HG; Irvine AE; Bhatia R; Holyoake TL. 2010. Bortezomib induces apoptosis in primitive chronic myeloid leukemia cells including LTC-IC and NOD/SCID repopulating cells. Blood 115(11):2241-50. [PubMed: 20068223]  [MGI Ref ID J:162612]

Heine D; Passmore HC; Patel V; Shultz LD; Ward-Bailey P; Cook SA; Davisson MT. 1996. Effect of the mouse scid mutation on meiotic recombination. Mamm Genome 7(7):497-500. [PubMed: 8672126]  [MGI Ref ID J:34473]

Hernandez-Novoa B; Bishop L; Logun C; Munson PJ; Elnekave E; Rangel ZG; Barb J; Danner RL; Kovacs JA. 2008. Immune responses to Pneumocystis murina are robust in healthy mice but largely absent in CD40 ligand-deficient mice. J Leukoc Biol 84(2):420-30. [PubMed: 18467653]  [MGI Ref ID J:138448]

Hertz CJ; Filutowicz H; Mansfield JM. 1998. Resistance to the African trypanosomes is IFN-gamma dependent. J Immunol 161(12):6775-83. [PubMed: 9862708]  [MGI Ref ID J:115095]

Hesselton RM; Greiner DL; Mordes JP; Rajan TV; Sullivan JL; Shultz LD. 1995. High levels of human peripheral blood mononuclear cell engraftment and enhanced susceptibility to human immunodeficiency virus type 1 infection in NOD/LtSz-scid/scid mice. J Infect Dis 172(4):974-82. [PubMed: 7561218]  [MGI Ref ID J:109911]

Hettmer S; Liu J; Miller CM; Lindsay MC; Sparks CA; Guertin DA; Bronson RT; Langenau DM; Wagers AJ. 2011. Sarcomas induced in discrete subsets of prospectively isolated skeletal muscle cells. Proc Natl Acad Sci U S A 108(50):20002-7. [PubMed: 22135462]  [MGI Ref ID J:180528]

Hilbert DM; Anderson AO; Holmes KL; Rudikoff S. 1994. Long-term lymphoid reconstitution of SCID mice suggests self-renewing B and T cell populations in peripheral and mucosal tissues. Transplantation 58(4):466-75. [PubMed: 8073516]  [MGI Ref ID J:19983]

Hioki K; Kuramochi T; Endoh S; Terada E; Ueyama Y; Ito M. 2001. Lack of B cell leakiness in BALB/cA-nu, scid double mutant mice. Exp Anim 50(1):67-72. [PubMed: 11326425]  [MGI Ref ID J:68089]

Hirai H; Verma M; Watanabe S; Tastad C; Asakura Y; Asakura A. 2010. MyoD regulates apoptosis of myoblasts through microRNA-mediated down-regulation of Pax3. J Cell Biol 191(2):347-65. [PubMed: 20956382]  [MGI Ref ID J:165481]

Hiramatsu H; Nishikomori R; Heike T; Ito M; Kobayashi K; Katamura K; Nakahata T. 2003. Complete reconstitution of human lymphocytes from cord blood CD34+ cells using the NOD/SCID/gammacnull mice model. Blood 102(3):873-80. [PubMed: 12689924]  [MGI Ref ID J:163372]

Hofling AA; Vogler C; Creer MH; Sands MS. 2003. Engraftment of human CD34+ cells leads to widespread distribution of donor-derived cells and correction of tissue pathology in a novel murine xenotransplantation model of lysosomal storage disease. Blood 101(5):2054-63. [PubMed: 12406886]  [MGI Ref ID J:109848]

Hoggatt J; Singh P; Sampath J; Pelus LM. 2009. Prostaglandin E2 enhances hematopoietic stem cell homing, survival, and proliferation. Blood 113(22):5444-55. [PubMed: 19324903]  [MGI Ref ID J:148898]

Holland JD; Gyorffy B; Vogel R; Eckert K; Valenti G; Fang L; Lohneis P; Elezkurtaj S; Ziebold U; Birchmeier W. 2013. Combined Wnt/beta-catenin, Met, and CXCL12/CXCR4 signals characterize basal breast cancer and predict disease outcome. Cell Rep 5(5):1214-27. [PubMed: 24290754]  [MGI Ref ID J:206839]

Holm TM; Jackson-Grusby L; Brambrink T; Yamada Y; Rideout WM 3rd; Jaenisch R. 2005. Global loss of imprinting leads to widespread tumorigenesis in adult mice. Cancer Cell 8(4):275-85. [PubMed: 16226703]  [MGI Ref ID J:104860]

Holodick NE; Vizconde T; Rothstein TL. 2014. B-1a cell diversity: nontemplated addition in B-1a cell Ig is determined by progenitor population and developmental location. J Immunol 192(5):2432-41. [PubMed: 24477911]  [MGI Ref ID J:209818]

Holopainen T; Saharinen P; D'Amico G; Lampinen A; Eklund L; Sormunen R; Anisimov A; Zarkada G; Lohela M; Helotera H; Tammela T; Benjamin LE; Yla-Herttuala S; Leow CC; Koh GY; Alitalo K. 2012. Effects of angiopoietin-2-blocking antibody on endothelial cell-cell junctions and lung metastasis. J Natl Cancer Inst 104(6):461-75. [PubMed: 22343031]  [MGI Ref ID J:184937]

Holt N; Wang J; Kim K; Friedman G; Wang X; Taupin V; Crooks GM; Kohn DB; Gregory PD; Holmes MC; Cannon PM. 2010. Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo. Nat Biotechnol 28(8):839-47. [PubMed: 20601939]  [MGI Ref ID J:162607]

Hontecillas R; Bassaganya-Riera J. 2007. Peroxisome proliferator-activated receptor gamma is required for regulatory CD4+ T cell-mediated protection against colitis. J Immunol 178(5):2940-9. [PubMed: 17312139]  [MGI Ref ID J:144105]

Horai R; Nakajima A; Habiro K; Kotani M; Nakae S; Matsuki T; Nambu A; Saijo S; Kotaki H; Sudo K; Okahara A; Tanioka H; Ikuse T; Ishii N; Schwartzberg PL; Abe R; Iwakura Y. 2004. TNF-alpha is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice. J Clin Invest 114(11):1603-11. [PubMed: 15578092]  [MGI Ref ID J:94429]

Hoshino T; Winkler-Pickett RT; Mason AT; Ortaldo JR; Young HA. 1999. IL-13 production by NK cells: IL-13-producing NK and T cells are present in vivo in the absence of IFN-gamma. J Immunol 162(1):51-9. [PubMed: 9886369]  [MGI Ref ID J:112424]

Houghtaling S; Newell A; Akkari Y; Taniguchi T; Olson S; Grompe M. 2005. Fancd2 functions in a double strand break repair pathway that is distinct from non-homologous end joining. Hum Mol Genet 14(20):3027-33. [PubMed: 16135554]  [MGI Ref ID J:102754]

Hsu DM; Agarwal S; Benham A; Coarfa C; Trahan DN; Chen Z; Stowers PN; Courtney AN; Lakoma A; Barbieri E; Metelitsa LS; Gunaratne P; Kim ES; Shohet JM. 2013. G-CSF Receptor Positive Neuroblastoma Subpopulations Are Enriched in Chemotherapy-Resistant or Relapsed Tumors and Are Highly Tumorigenic. Cancer Res 73(13):4134-46. [PubMed: 23687340]  [MGI Ref ID J:199119]

Hu Z; Van Rooijen N; Yang YG. 2011. Macrophages prevent human red blood cell reconstitution in immunodeficient mice. Blood 118(22):5938-46. [PubMed: 21926352]  [MGI Ref ID J:178783]

Hua C; Chang B; Ma B-L; Li Y; Wang G. 1992. Reduction of lymphokine-activated killer cell activity by the introduction of the beige gene into SCID mice ILAR News 34(1-2):S15-S16.  [MGI Ref ID J:2627]

Huang P; Huo Y; Lou LX; Li H; Barnstable CJ; Zhang C; Zhang SS. 2013. CD4 positive T helper cells contribute to retinal ganglion cell death in mouse model of ischemia reperfusion injury. Exp Eye Res 115:131-9. [PubMed: 23792169]  [MGI Ref ID J:210412]

Hubner A; Mulholland DJ; Standen CL; Karasarides M; Cavanagh-Kyros J; Barrett T; Chi H; Greiner DL; Tournier C; Sawyers CL; Flavell RA; Wu H; Davis RJ. 2012. JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate. Proc Natl Acad Sci U S A 109(30):12046-51. [PubMed: 22753496]  [MGI Ref ID J:186492]

Hubner MP; Shi Y; Torrero MN; Mueller E; Larson D; Soloviova K; Gondorf F; Hoerauf A; Killoran KE; Stocker JT; Davies SJ; Tarbell KV; Mitre E. 2012. Helminth protection against autoimmune diabetes in nonobese diabetic mice is independent of a type 2 immune shift and requires TGF-beta. J Immunol 188(2):559-68. [PubMed: 22174447]  [MGI Ref ID J:180789]

Hugues S; Mougneau E; Ferlin W; Jeske D; Hofman P; Homann D; Beaudoin L; Schrike C; Von Herrath M; Lehuen A; Glaichenhaus N. 2002. Tolerance to islet antigens and prevention from diabetes induced by limited apoptosis of pancreatic beta cells. Immunity 16(2):169-81. [PubMed: 11869679]  [MGI Ref ID J:132052]

Hull ML; Johan MZ; Hodge WL; Robertson SA; Ingman WV. 2012. Host-derived TGFB1 deficiency suppresses lesion development in a mouse model of endometriosis. Am J Pathol 180(3):880-7. [PubMed: 22210480]  [MGI Ref ID J:181959]

Hunter CA; Ellis-Neyes LA; Slifer T; Kanaly S; Grunig G; Fort M; Rennick D; Araujo FG. 1997. IL-10 is required to prevent immune hyperactivity during infection with Trypanosoma cruzi. J Immunol 158(7):3311-6. [PubMed: 9120288]  [MGI Ref ID J:110835]

Ichimura Y; Waguri S; Sou YS; Kageyama S; Hasegawa J; Ishimura R; Saito T; Yang Y; Kouno T; Fukutomi T; Hoshii T; Hirao A; Takagi K; Mizushima T; Motohashi H; Lee MS; Yoshimori T; Tanaka K; Yamamoto M; Komatsu M. 2013. Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. Mol Cell 51(5):618-31. [PubMed: 24011591]  [MGI Ref ID J:203811]

Ingman WV; Robertson SA. 2008. Mammary gland development in transforming growth factor beta1 null mutant mice: systemic and epithelial effects. Biol Reprod 79(4):711-7. [PubMed: 18614704]  [MGI Ref ID J:140882]

Ingman WV; Robertson SA. 2007. Transforming growth factor-beta1 null mutation causes infertility in male mice associated with testosterone deficiency and sexual dysfunction. Endocrinology 148(8):4032-43. [PubMed: 17478551]  [MGI Ref ID J:129629]

Ingman WV; Robker RL; Woittiez K; Robertson SA. 2006. Null mutation in transforming growth factor beta1 disrupts ovarian function and causes oocyte incompetence and early embryo arrest. Endocrinology 147(2):835-45. [PubMed: 16269452]  [MGI Ref ID J:129446]

Ippolito GC; Hoi KH; Reddy ST; Carroll SM; Ge X; Rogosch T; Zemlin M; Shultz LD; Ellington AD; Vandenberg CL; Georgiou G. 2012. Antibody repertoires in humanized NOD-scid-IL2Rgamma(null) mice and human B cells reveals human-like diversification and tolerance checkpoints in the mouse. PLoS One 7(4):e35497. [PubMed: 22558161]  [MGI Ref ID J:187283]

Ishii T; Zhao Y; Sozer S; Shi J; Zhang W; Hoffman R; Xu M. 2007. Behavior of CD34+ cells isolated from patients with polycythemia vera in NOD/SCID mice. Exp Hematol 35(11):1633-40. [PubMed: 17764815]  [MGI Ref ID J:132540]

Ishii-Ohba H; Kobayashi S; Nishimura M; Shimada Y; Tsuji H; Sado T; Ogiu T. 2007. Existence of a threshold-like dose for gamma-ray induction of thymic lymphomas and no susceptibility to radiation-induced solid tumors in SCID mice. Mutat Res 619(1-2):124-33. [PubMed: 17397880]  [MGI Ref ID J:120953]

Ishikawa F; Yasukawa M; Lyons B; Yoshida S; Miyamoto T; Yoshimoto G; Watanabe T; Akashi K; Shultz LD; Harada M. 2005. Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice. Blood 106(5):1565-73. [PubMed: 15920010]  [MGI Ref ID J:142411]

Ito M; Hiramatsu H; Kobayashi K; Suzue K; Kawahata M; Hioki K; Ueyama Y; Koyanagi Y; Sugamura K; Tsuji K; Heike T; Nakahata T. 2002. NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells. Blood 100(9):3175-82. [PubMed: 12384415]  [MGI Ref ID J:163373]

Ito R; Katano I; Ida-Tanaka M; Kamisako T; Kawai K; Suemizu H; Aiso S; Ito M. 2012. Efficient xenoengraftment in severe immunodeficient NOD/Shi-scid IL2rgammanull mice is attributed to a lack of CD11c+B220+CD122+ cells. J Immunol 189(9):4313-20. [PubMed: 23018460]  [MGI Ref ID J:190612]

Ito R; Negishi N; Irie N; Matsuo K; Suzuki D; Katano I; Hayakawa E; Kawai K; Kamisako T; Eto T; Ogura T; Hozumi K; Ando K; Aiso S; Tamaoki N; Habu S; Ito M. 2012. Osteosclerosis and inhibition of human hematopoiesis in NOG mice expressing human Delta-like 1 in osteoblasts. Exp Hematol 40(11):953-963.e3. [PubMed: 22771497]  [MGI Ref ID J:203591]

Ito R; Takahashi T; Katano I; Kawai K; Kamisako T; Ogura T; Ida-Tanaka M; Suemizu H; Nunomura S; Ra C; Mori A; Aiso S; Ito M. 2013. Establishment of a human allergy model using human IL-3/GM-CSF-transgenic NOG mice. J Immunol 191(6):2890-9. [PubMed: 23956433]  [MGI Ref ID J:205873]

Ito T; Seyama T; Kyoizumi S; Teraoka S; Iwamoto KS; Mizuno T; Tsuyama N; Asahara T; Dohi K; Akiyama M. 1995. The usefulness of severe combined immunodeficiency (SCID) mice to study human carcinogenesis. Cancer Lett 88(1):113-7. [PubMed: 7850767]  [MGI Ref ID J:23712]

Iwai H; Abe M; Hirose S; Tsushima F; Tezuka K; Akiba H; Yagita H; Okumura K; Kohsaka H; Miyasaka N; Azuma M. 2003. Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis. J Immunol 171(6):2848-54. [PubMed: 12960306]  [MGI Ref ID J:120381]

Jaakkola I; Jalkanen S; Hanninen A. 2003. Diabetogenic T cells are primed both in pancreatic and gut-associated lymph nodes in NOD mice. Eur J Immunol 33(12):3255-64. [PubMed: 14635033]  [MGI Ref ID J:87142]

Jaeschke A; Rincon M; Doran B; Reilly J; Neuberg D; Greiner DL; Shultz LD; Rossini AA; Flavell RA; Davis RJ. 2005. Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes. Proc Natl Acad Sci U S A 102(19):6931-5. [PubMed: 15867147]  [MGI Ref ID J:99056]

Jaiswal S; Pearson T; Friberg H; Shultz LD; Greiner DL; Rothman AL; Mathew A. 2009. Dengue virus infection and virus-specific HLA-A2 restricted immune responses in humanized NOD-scid IL2rgammanull mice. PLoS One 4(10):e7251. [PubMed: 19802382]  [MGI Ref ID J:154110]

Janes MR; Limon JJ; So L; Chen J; Lim RJ; Chavez MA; Vu C; Lilly MB; Mallya S; Ong ST; Konopleva M; Martin MB; Ren P; Liu Y; Rommel C; Fruman DA. 2010. Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor. Nat Med 16(2):205-13. [PubMed: 20072130]  [MGI Ref ID J:162611]

Jimenez de Bagues MP; de Martino A; Quintana JF; Alcaraz A; Pardo J. 2011. Course of Infection with the Emergent Pathogen Brucella microti in Immunocompromised Mice. Infect Immun 79(10):3934-9. [PubMed: 21825066]  [MGI Ref ID J:175995]

Johnson RM; Papp E; Grandal I; Kowalski PE; Nutter L; Wong RC; Joseph-George AM; Danska JS; Guidos CJ. 2014. MuLV-related endogenous retroviral elements and Flt3 participate in aberrant end-joining events that promote B-cell leukemogenesis. Genes Dev 28(11):1179-90. [PubMed: 24888589]  [MGI Ref ID J:211638]

Jones-Carson J; Vazquez-Torres A; Balish E. 1995. Defective killing of Candida albicans hyphae by neutrophils from beige mice. J Infect Dis 171(6):1664-7. [PubMed: 7769315]  [MGI Ref ID J:25930]

Juelke K; Killig M; Luetke-Eversloh M; Parente E; Gruen J; Morandi B; Ferlazzo G; Thiel A; Schmitt-Knosalla I; Romagnani C. 2010. CD62L expression identifies a unique subset of polyfunctional CD56dim NK cells. Blood 116(8):1299-307. [PubMed: 20505160]  [MGI Ref ID J:163485]

Jun HS; Santamaria P; Lim HW; Zhang ML; Yoon JW. 1999. Absolute requirement of macrophages for the development and activation of beta-cell cytotoxic CD8+ T-cells in T-cell receptor transgenic NOD mice. Diabetes 48(1):34-42. [PubMed: 9892220]  [MGI Ref ID J:108751]

Kagari T; Doi H; Shimozato T. 2002. The importance of IL-1 beta and TNF-alpha, and the noninvolvement of IL-6, in the development of monoclonal antibody-induced arthritis. J Immunol 169(3):1459-66. [PubMed: 12133972]  [MGI Ref ID J:120707]

Kahiri CN; Khalil MW; Tekpetey F; Kidder GM. 2006. Leydig cell function in mice lacking connexin43. Reproduction 132(4):607-616. [PubMed: 17008472]  [MGI Ref ID J:112888]

Kalaany NY; Sabatini DM. 2009. Tumours with PI3K activation are resistant to dietary restriction. Nature 458(7239):725-31. [PubMed: 19279572]  [MGI Ref ID J:147281]

Kalscheuer H; Onoe T; Dahmani A; Li HW; Holzl M; Yamada K; Sykes M. 2014. Xenograft tolerance and immune function of human T cells developing in pig thymus xenografts. J Immunol 192(7):3442-50. [PubMed: 24591363]  [MGI Ref ID J:209878]

Kariya R; Taura M; Suzu S; Kai H; Katano H; Okada S. 2014. HIV protease inhibitor Lopinavir induces apoptosis of primary effusion lymphoma cells via suppression of NF-kappaB pathway. Cancer Lett 342(1):52-9. [PubMed: 24012878]  [MGI Ref ID J:204517]

Katakura K; Lee J; Rachmilewitz D; Li G; Eckmann L; Raz E. 2005. Toll-like receptor 9-induced type I IFN protects mice from experimental colitis. J Clin Invest 115(3):695-702. [PubMed: 15765149]  [MGI Ref ID J:110027]

Katakura T; Yoshida T; Kobayashi M; Herndon DN; Suzuki F. 2005. Immunological control of methicillin-resistant Staphylococcus aureus (MRSA) infection in an immunodeficient murine model of thermal injuries. Clin Exp Immunol 142(3):419-25. [PubMed: 16297152]  [MGI Ref ID J:107603]

Kawaguchi-Miyashita M; Shimada S; Kurosu H; Kato-Nagaoka N; Matsuoka Y; Ohwaki M; Ishikawa H; Nanno M. 2001. An accessory role of TCRgammadelta (+) cells in the exacerbation of inflammatory bowel disease in TCRalpha mutant mice. Eur J Immunol 31(4):980-8. [PubMed: 11298322]  [MGI Ref ID J:68810]

Kawahara M; Pandolfi A; Bartholdy B; Barreyro L; Will B; Roth M; Okoye-Okafor UC; Todorova TI; Figueroa ME; Melnick A; Mitsiades CS; Steidl U. 2012. H2.0-like homeobox regulates early hematopoiesis and promotes acute myeloid leukemia. Cancer Cell 22(2):194-208. [PubMed: 22897850]  [MGI Ref ID J:191823]

Kayama H; Ueda Y; Sawa Y; Jeon SG; Ma JS; Okumura R; Kubo A; Ishii M; Okazaki T; Murakami M; Yamamoto M; Yagita H; Takeda K. 2012. Intestinal CX3C chemokine receptor 1high (CX3CR1high) myeloid cells prevent T-cell-dependent colitis. Proc Natl Acad Sci U S A 109(13):5010-5. [PubMed: 22403066]  [MGI Ref ID J:182225]

Kazerounian S; Gerald D; Huang M; Chin YR; Udayakumar D; Zheng N; O'Donnell RK; Perruzzi C; Mangiante L; Pourat J; Phung TL; Bravo-Nuevo A; Shechter S; McNamara S; Duhadaway JB; Kocher ON; Brown LF; Toker A; Prendergast GC; Benjamin LE. 2013. RhoB differentially controls Akt function in tumor cells and stromal endothelial cells during breast tumorigenesis. Cancer Res 73(1):50-61. [PubMed: 23135917]  [MGI Ref ID J:194113]

Kelly MN; Zheng M; Ruan S; Kolls J; D'Souza A; Shellito JE. 2013. Memory CD4+ T Cells Are Required for Optimal NK Cell Effector Functions against the Opportunistic Fungal Pathogen Pneumocystis murina. J Immunol 190(1):285-95. [PubMed: 23203926]  [MGI Ref ID J:190830]

Kemp CJ; Vo K; Gurley KE. 1999. Resistance to skin tumorigenesis in DNAPK-deficient SCID mice is not due to immunodeficiency but results from hypersensitivity to TPA-induced apoptosis. Carcinogenesis 20(11):2051-6. [PubMed: 10545405]  [MGI Ref ID J:58425]

Khaled AR; Li WQ; Huang J; Fry TJ; Khaled AS; Mackall CL; Muegge K; Young HA; Durum SK. 2002. Bax deficiency partially corrects interleukin-7 receptor alpha deficiency. Immunity 17(5):561-73. [PubMed: 12433363]  [MGI Ref ID J:93139]

Kharbanda S; Pandey P; Jin S; Inoue S; Bharti A; Yuan ZM; Weichselbaum R; Weaver D; Kufe D. 1997. Functional interaction between DNA-PK and c-Abl in response to DNA damage. Nature 386(6626):732-5. [PubMed: 9109492]  [MGI Ref ID J:116399]

Kiaris H; Chatzistamou I; Trimis G; Frangou-Plemmenou M; Pafiti-Kondi A; Kalofoutis A. 2005. Evidence for nonautonomous effect of p53 tumor suppressor in carcinogenesis. Cancer Res 65(5):1627-30. [PubMed: 15753354]  [MGI Ref ID J:97031]

Kiefer K; Nakajima PB; Oshinsky J; Seeholzer SH; Radic M; Bosma GC; Bosma MJ. 2008. Antigen receptor editing in anti-DNA transitional B cells deficient for surface IgM. J Immunol 180(9):6094-106. [PubMed: 18424731]  [MGI Ref ID J:160356]

Kiefer K; Oshinsky J; Kim J; Nakajima PB; Bosma GC; Bosma MJ. 2007. The catalytic subunit of DNA-protein kinase (DNA-PKcs) is not required for Ig class-switch recombination. Proc Natl Acad Sci U S A 104(8):2843-8. [PubMed: 17296939]  [MGI Ref ID J:125895]

Kim KD; Srikanth S; Yee MK; Mock DC; Lawson GW; Gwack Y. 2011. ORAI1 deficiency impairs activated T cell death and enhances T cell survival. J Immunol 187(7):3620-30. [PubMed: 21873530]  [MGI Ref ID J:179333]

Kim S; Dubrovska A; Salamone RJ; Walker JR; Grandinetti KB; Bonamy GM; Orth AP; Elliott J; Porta DG; Garcia-Echeverria C; Reddy VA. 2013. FGFR2 promotes breast tumorigenicity through maintenance of breast tumor-initiating cells. PLoS One 8(1):e51671. [PubMed: 23300950]  [MGI Ref ID J:195822]

King MA; Covassin L; Brehm MA; Racki W; Pearson T; Leif J; Laning J; Fodor W; Foreman O; Burzenski L; Chase TH; Gott B; Rossini AA; Bortell R; Shultz LD; Greiner DL. 2009. Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex. Clin Exp Immunol 157(1):104-18. [PubMed: 19659776]  [MGI Ref ID J:151390]

Kinkel SA; Galeev R; Flensburg C; Keniry A; Breslin K; Gilan O; Lee S; Liu J; Chen K; Gearing LJ; Moore DL; Alexander WS; Dawson M; Majewski IJ; Oshlack A; Larsson J; Blewitt ME. 2015. Jarid2 regulates hematopoietic stem cell function by acting with polycomb repressive complex 2. Blood 125(12):1890-900. [PubMed: 25645357]  [MGI Ref ID J:222052]

Kitamura K; Nakamoto Y; Kaneko S; Mukaida N. 2004. Pivotal roles of interleukin-6 in transmural inflammation in murine T cell transfer colitis. J Leukoc Biol 76(6):1111-7. [PubMed: 15339938]  [MGI Ref ID J:94173]

Kitaura H; Zhou P; Kim HJ; Novack DV; Ross FP; Teitelbaum SL. 2005. M-CSF mediates TNF-induced inflammatory osteolysis. J Clin Invest 115(12):3418-27. [PubMed: 16294221]  [MGI Ref ID J:104533]

Klein MA; Frigg R; Flechsig E; Raeber AJ; Kalinke U; Bluethmann H; Bootz F; Suter M; Zinkernagel RM; Aguzzi A. 1997. A crucial role for B cells in neuroinvasive scrapie [see comments] Nature 390(6661):687-90. [PubMed: 9414161]  [MGI Ref ID J:44933]

Klug F; Prakash H; Huber PE; Seibel T; Bender N; Halama N; Pfirschke C; Voss RH; Timke C; Umansky L; Klapproth K; Schakel K; Garbi N; Jager D; Weitz J; Schmitz-Winnenthal H; Hammerling GJ; Beckhove P. 2013. Low-dose irradiation programs macrophage differentiation to an iNOS(+)/M1 phenotype that orchestrates effective T cell immunotherapy. Cancer Cell 24(5):589-602. [PubMed: 24209604]  [MGI Ref ID J:206743]

Kobayashi M; Nakamura K; Cornforth M; Suzuki F. 2012. Role of M2b macrophages in the acceleration of bacterial translocation and subsequent sepsis in mice exposed to whole body [137Cs] gamma-irradiation. J Immunol 189(1):296-303. [PubMed: 22664870]  [MGI Ref ID J:188934]

Kodama T; Hikita H; Kawaguchi T; Saito Y; Tanaka S; Shigekawa M; Shimizu S; Li W; Miyagi T; Kanto T; Hiramatsu N; Tatsumi T; Takehara T. 2013. The Bcl-2 homology domain 3 (BH3)-only proteins Bim and bid are functionally active and restrained by anti-apoptotic Bcl-2 family proteins in healthy liver. J Biol Chem 288(42):30009-18. [PubMed: 23986435]  [MGI Ref ID J:203931]

Kometani K; Aoki M; Kawamata S; Shinozuka Y; Era T; Taniwaki M; Hattori M; Minato N. 2006. Role of SPA-1 in phenotypes of chronic myelogenous leukemia induced by BCR-ABL-expressing hematopoietic progenitors in a mouse model. Cancer Res 66(20):9967-76. [PubMed: 17047059]  [MGI Ref ID J:114993]

Kong L; Robinson CP; Peck AB; Vela-Roch N; Sakata KM; Dang H; Talal N; Humphreys-Beher MG. 1998. Inappropriate apoptosis of salivary and lacrimal gland epithelium of immunodeficient NOD-scid mice. Clin Exp Rheumatol 16(6):675-81. [PubMed: 9844759]  [MGI Ref ID J:53650]

Kota DJ; Wiggins LL; Yoon N; Lee RH. 2013. TSG-6 produced by hMSCs delays the onset of autoimmune diabetes by suppressing Th1 development and enhancing tolerogenicity. Diabetes 62(6):2048-58. [PubMed: 23349496]  [MGI Ref ID J:208563]

Krishnamurthy S; Warner KA; Dong Z; Imai A; Nor C; Ward BB; Helman JI; Taichman RS; Bellile EL; McCauley LK; Polverini PJ; Prince ME; Wicha MS; Nor JE. 2014. Endothelial interleukin-6 defines the tumorigenic potential of primary human cancer stem cells. Stem Cells 32(11):2845-57. [PubMed: 25078284]  [MGI Ref ID J:218558]

Ksander BR; Kolovou PE; Wilson BJ; Saab KR; Guo Q; Ma J; McGuire SP; Gregory MS; Vincent WJ; Perez VL; Cruz-Guilloty F; Kao WW; Call MK; Tucker BA; Zhan Q; Murphy GF; Lathrop KL; Alt C; Mortensen LJ; Lin CP; Zieske JD; Frank MH; Frank NY. 2014. ABCB5 is a limbal stem cell gene required for corneal development and repair. Nature 511(7509):353-7. [PubMed: 25030174]  [MGI Ref ID J:213708]

Kumar P; Ban HS; Kim SS; Wu H; Pearson T; Greiner DL; Laouar A; Yao J; Haridas V; Habiro K; Yang YG; Jeong JH; Lee KY; Kim YH; Kim SW; Peipp M; Fey GH; Manjunath N; Shultz LD; Lee SK; Shankar P. 2008. T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice. Cell 134(4):577-86. [PubMed: 18691745]  [MGI Ref ID J:142409]

Kunisawa J; Gohda M; Kurashima Y; Ishikawa I; Higuchi M; Kiyono H. 2008. Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NF{kappa}B-inducing kinase in stromal cells. Blood 111(9):4646-52. [PubMed: 18292290]  [MGI Ref ID J:134340]

Kupfer TM; Crawford ML; Pham K; Gill RG. 2005. MHC-mismatched islet allografts are vulnerable to autoimmune recognition in vivo. J Immunol 175(4):2309-16. [PubMed: 16081800]  [MGI Ref ID J:107508]

Kurkjian C; Hollifield M; Lines JL; Rogosky A; Empey KM; Qureshi M; Brown SA; Garvy BA. 2012. Alveolar Macrophages in Neonatal Mice Are Inherently Unresponsive to Pneumocystis murina Infection. Infect Immun 80(8):2835-46. [PubMed: 22665378]  [MGI Ref ID J:186637]

Kwun J; Hu H; Schadde E; Roenneburg D; Sullivan KA; DeMartino J; Burlingham WJ; Knechtle SJ. 2007. Altered distribution of H60 minor H antigen-specific CD8 T cells and attenuated chronic vasculopathy in minor histocompatibility antigen mismatched heart transplantation in Cxcr3-/- mouse recipients. J Immunol 179(12):8016-25. [PubMed: 18056341]  [MGI Ref ID J:155042]

Larcher F; Del Rio M; Serrano F; Segovia JC; Ramirez A; Meana A; Page A; Abad JL; Gonzalez MA; Bueren J; Bernad A; Jorcano JL. 2001. A cutaneous gene therapy approach to human leptin deficiencies: correction of the murine ob/ob phenotype using leptin-targeted keratinocyte grafts. FASEB J 15(9):1529-38. [PubMed: 11427484]  [MGI Ref ID J:115148]

Lazarus JJ; Meadows MJ; Lintner RE; Wooten RM. 2006. IL-10 deficiency promotes increased Borrelia burgdorferi clearance predominantly through enhanced innate immune responses. J Immunol 177(10):7076-85. [PubMed: 17082624]  [MGI Ref ID J:140484]

Lee HM; Wysoczynski M; Liu R; Shin DM; Kucia M; Botto M; Ratajczak J; Ratajczak MZ. 2010. Mobilization studies in complement-deficient mice reveal that optimal AMD3100 mobilization of hematopoietic stem cells depends on complement cascade activation by AMD3100-stimulated granulocytes. Leukemia 24(3):573-82. [PubMed: 20033053]  [MGI Ref ID J:158026]

Lee SM; Yang H; Tartar DM; Gao B; Luo X; Ye SQ; Zaghouani H; Fang D. 2011. Prevention and treatment of diabetes with resveratrol in a non-obese mouse model of type 1 diabetes. Diabetologia :. [PubMed: 21340626]  [MGI Ref ID J:169586]

Lefevre S; Knedla A; Tennie C; Kampmann A; Wunrau C; Dinser R; Korb A; Schnaker EM; Tarner IH; Robbins PD; Evans CH; Sturz H; Steinmeyer J; Gay S; Scholmerich J; Pap T; Muller-Ladner U; Neumann E. 2009. Synovial fibroblasts spread rheumatoid arthritis to unaffected joints. Nat Med 15(12):1414-20. [PubMed: 19898488]  [MGI Ref ID J:155763]

Leiter EH; Prochazka M; Shultz LD. 1987. Effect of immunodeficiency on diabetogenesis in genetically diabetic (db/db) mice. J Immunol 138(10):3224-9. [PubMed: 3553324]  [MGI Ref ID J:32752]

Leung J; Suh WK. 2013. Host B7-H4 regulates antitumor T cell responses through inhibition of myeloid-derived suppressor cells in a 4T1 tumor transplantation model. J Immunol 190(12):6651-61. [PubMed: 23686485]  [MGI Ref ID J:204842]

Li B; Sharpe EE; Maupin AB; Teleron AA; Pyle AL; Carmeliet P; Young PP. 2006. VEGF and PlGF promote adult vasculogenesis by enhancing EPC recruitment and vessel formation at the site of tumor neovascularization. FASEB J 20(9):1495-7. [PubMed: 16754748]  [MGI Ref ID J:111344]

Li CR; Mueller EE; Bradley LM. 2014. Islet antigen-specific Th17 cells can induce TNF-alpha-dependent autoimmune diabetes. J Immunol 192(4):1425-32. [PubMed: 24446517]  [MGI Ref ID J:209355]

Li E; Zhou P; Singer SM. 2006. Neuronal nitric oxide synthase is necessary for elimination of Giardia lamblia infections in mice. J Immunol 176(1):516-21. [PubMed: 16365445]  [MGI Ref ID J:126256]

Li G; Zhang L; Chen E; Wang J; Jiang X; Chen JH; Wickman G; Amundson K; Bergqvist S; Zobel J; Buckman D; Baxi SM; Bender SL; Casperson GF; Hu-Lowe DD. 2010. Dual functional monoclonal antibody PF-04605412 targets integrin alpha5beta1 and elicits potent antibody-dependent cellular cytotoxicity. Cancer Res 70(24):10243-54. [PubMed: 21159645]  [MGI Ref ID J:167600]

Li SW; Koya V; Li Y; Donelan W; Lin P; Reeves WH; Yang LJ. 2010. Pancreatic duodenal homeobox 1 protein is a novel beta-cell-specific autoantigen for type I diabetes. Lab Invest 90(1):31-9. [PubMed: 19901909]  [MGI Ref ID J:156607]

Li T; Ramirez K; Palacios R. 1996. Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes. Cell Growth Differ 7(1):107-14. [PubMed: 8788039]  [MGI Ref ID J:31364]

Li X; Sterling JA; Fan KH; Vessella RL; Shyr Y; Hayward SW; Matrisian LM; Bhowmick NA. 2012. Loss of TGF-beta responsiveness in prostate stromal cells alters chemokine levels and facilitates the development of mixed osteoblastic/osteolytic bone lesions. Mol Cancer Res 10(4):494-503. [PubMed: 22290877]  [MGI Ref ID J:205394]

Li Y; Su J; Dingzhang X; Zhang J; Yoshimoto M; Liu S; Bijian K; Gupta A; Squire JA; Alaoui Jamali MA; Bismar TA. 2011. PTEN deletion and heme oxygenase-1 overexpression cooperate in prostate cancer progression and are associated with adverse clinical outcome. J Pathol 224(1):90-100. [PubMed: 21381033]  [MGI Ref ID J:171247]

Liao MJ; Zhang XX; Hill R; Gao J; Qumsiyeh MB; Nichols W; Van Dyke T. 1998. No requirement for V(D)J recombination in p53-deficient thymic lymphoma. Mol Cell Biol 18(6):3495-501. [PubMed: 9584189]  [MGI Ref ID J:47667]

Libby SJ; Brehm MA; Greiner DL; Shultz LD; McClelland M; Smith KD; Cookson BT; Karlinsey JE; Kinkel TL; Porwollik S; Canals R; Cummings LA; Fang FC. 2010. Humanized nonobese diabetic-scid IL2rgammanull mice are susceptible to lethal Salmonella Typhi infection. Proc Natl Acad Sci U S A 107(35):15589-94. [PubMed: 20713716]  [MGI Ref ID J:163745]

Liebe B; Petukhova G; Barchi M; Bellani M; Braselmann H; Nakano T; Pandita TK; Jasin M; Fornace A; Meistrich ML; Baarends WM; Schimenti J; de Lange T; Keeney S; Camerini-Otero RD; Scherthan H. 2006. Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages. Exp Cell Res 312(19):3768-81. [PubMed: 17010969]  [MGI Ref ID J:147391]

Liebler JM; Lutzko C; Banfalvi A; Senadheera D; Aghamohammadi N; Crandall ED; Borok Z. 2008. Retention of human bone marrow-derived cells in murine lungs following bleomycin-induced lung injury. Am J Physiol Lung Cell Mol Physiol 295(2):L285-92. [PubMed: 18515407]  [MGI Ref ID J:138638]

Lieke T; Steeg C; Graefe SE; Fleischer B; Jacobs T. 2006. Interaction of natural killer cells with Trypanosoma cruzi-infected fibroblasts. Clin Exp Immunol 145(2):357-64. [PubMed: 16879257]  [MGI Ref ID J:112856]

Liu D; Zhang T; Marshall AJ; Okkenhaug K; Vanhaesebroeck B; Uzonna JE. 2009. The p110delta isoform of phosphatidylinositol 3-kinase controls susceptibility to Leishmania major by regulating expansion and tissue homing of regulatory T cells. J Immunol 183(3):1921-33. [PubMed: 19596993]  [MGI Ref ID J:151583]

Liu Y; Carlsson R; Comabella M; Wang J; Kosicki M; Carrion B; Hasan M; Wu X; Montalban X; Dziegiel MH; Sellebjerg F; Sorensen PS; Helin K; Issazadeh-Navikas S. 2014. FoxA1 directs the lineage and immunosuppressive properties of a novel regulatory T cell population in EAE and MS. Nat Med 20(3):272-82. [PubMed: 24531377]  [MGI Ref ID J:208760]

Llamas B; Belanger S; Picard S; Deschepper CF. 2007. Cardiac mass and cardiomyocyte size are governed by different genetic loci on either autosomes or chromosome Y in recombinant inbred mice. Physiol Genomics 31(2):176-82. [PubMed: 17566079]  [MGI Ref ID J:127219]

Lode HN; Xiang R; Pertl U; Forster E; Schoenberger SP; Gillies SD; Reisfeld RA. 2000. Melanoma immunotherapy by targeted IL-2 depends on CD4(+) T-cell help mediated by CD40/CD40L interaction. J Clin Invest 105(11):1623-30. [PubMed: 10841521]  [MGI Ref ID J:62762]

Londono D; Bai Y; Zuckert WR; Gelderblom H; Cadavid D. 2005. Cardiac apoptosis in severe relapsing fever borreliosis. Infect Immun 73(11):7669-76. [PubMed: 16239571]  [MGI Ref ID J:104291]

Lou YR; Peng QY; Li T; Medvecky CM; Lin Y; Shih WJ; Conney AH; Shapses S; Wagner GC; Lu YP. 2011. Effects of high-fat diets rich in either omega-3 or omega-6 fatty acids on UVB-induced skin carcinogenesis in SKH-1 mice. Carcinogenesis 32(7):1078-84. [PubMed: 21525235]  [MGI Ref ID J:173643]

Lu L; Ghose AK; Quail MR; Albom MS; Durkin JT; Holskin BP; Angeles TS; Meyer SL; Ruggeri BA; Cheng M. 2009. ALK mutants in the kinase domain exhibit altered kinase activity and differential sensitivity to small molecule ALK inhibitors. Biochemistry 48(16):3600-9. [PubMed: 19249873]  [MGI Ref ID J:149248]

Lu M; Kardel MD; O'Connor MD; Eaves CJ. 2009. Enhanced generation of hematopoietic cells from human hepatocarcinoma cell-stimulated human embryonic and induced pluripotent stem cells. Exp Hematol 37(8):924-36. [PubMed: 19481135]  [MGI Ref ID J:151435]

Lucas S; Taront S; Magnan C; Fauconnier L; Delacre M; Macia L; Delanoye A; Verwaerde C; Spriet C; Saule P; Goormachtigh G; Heliot L; Ktorza A; Movassat J; Polakowska R; Auriault C; Poulain-Godefroy O; Di Santo J; Froguel P; Wolowczuk I. 2012. Interleukin-7 regulates adipose tissue mass and insulin sensitivity in high-fat diet-fed mice through lymphocyte-dependent and independent mechanisms. PLoS One 7(6):e40351. [PubMed: 22768283]  [MGI Ref ID J:187900]

Lukacs RU; Memarzadeh S; Wu H; Witte ON. 2010. Bmi-1 is a crucial regulator of prostate stem cell self-renewal and malignant transformation. Cell Stem Cell 7(6):682-93. [PubMed: 21112563]  [MGI Ref ID J:168487]

Luo X; Tarbell KV; Yang H; Pothoven K; Bailey SL; Ding R; Steinman RM; Suthanthiran M. 2007. Dendritic cells with TGF-beta1 differentiate naive CD4+CD25- T cells into islet-protective Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A 104(8):2821-6. [PubMed: 17307871]  [MGI Ref ID J:125908]

MacKenzie DA; Sollinger HW; Hullett DA. 1996. Acute graft rejection of human fetal pancreas allografts using donor-specific human peripheral blood lymphocytes in the SCID mouse. Transplantation 61(10):1461-4. [PubMed: 8633371]  [MGI Ref ID J:33268]

Madlambayan GJ; Meacham AM; Hosaka K; Mir S; Jorgensen M; Scott EW; Siemann DW; Cogle CR. 2010. Leukemia regression by vascular disruption and antiangiogenic therapy. Blood 116(9):1539-47. [PubMed: 20472832]  [MGI Ref ID J:164541]

Maeda K; Nagasawa H; Furukawa A; Hisaeda H; Himeno K. 1994. Split tolerance between spleen and lymph node cells in severe combined immunodeficiency mice grafted with AKR fetal liver cells. Int Immunol 6(8):1213-9. [PubMed: 7981149]  [MGI Ref ID J:22574]

Mahler M; Bristol IJ; Leiter EH; Workman AE; Birkenmeier EH; Elson CO; Sundberg JP. 1998. Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis. Am J Physiol 274(3 Pt 1):G544-51. [PubMed: 9530156]  [MGI Ref ID J:46553]

Majeti R; Park CY; Weissman IL. 2007. Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood. Cell Stem Cell 1(6):635-45. [PubMed: 18371405]  [MGI Ref ID J:142413]

Mamalaki C; Elliott J; Norton T; Yannoutsos N; Townsend AR; Chandler P; Simpson E; Kioussis D. 1993. Positive and negative selection in transgenic mice expressing a T-cell receptor specific for influenza nucleoprotein and endogenous superantigen. Dev Immunol 3(3):159-74. [PubMed: 8281031]  [MGI Ref ID J:113713]

Mangada J; Pearson T; Brehm MA; Wicker LS; Peterson LB; Shultz LD; Serreze DV; Rossini AA; Greiner DL. 2009. Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice. Diabetes 58(1):165-73. [PubMed: 18984741]  [MGI Ref ID J:146982]

Manis JP; Dudley D; Kaylor L; Alt FW. 2002. IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells. Immunity 16(4):607-17. [PubMed: 11970883]  [MGI Ref ID J:113521]

Manuel JA; Gawronska-Kozak B. 2006. Matrix metalloproteinase 9 (MMP-9) is upregulated during scarless wound healing in athymic nude mice. Matrix Biol 25(8):505-14. [PubMed: 17010584]  [MGI Ref ID J:116052]

Marino E; Walters SN; Villanueva JE; Richards JL; Mackay CR; Grey ST. 2014. BAFF regulates activation of self-reactive T cells through B-cell dependent mechanisms and mediates protection in NOD mice. Eur J Immunol 44(4):983-93. [PubMed: 24435807]  [MGI Ref ID J:209374]

Marron MP; Graser RT; Chapman HD; Serreze DV. 2002. Functional evidence for the mediation of diabetogenic T cell responses by HLA-A2.1 MHC class I molecules through transgenic expression in NOD mice. Proc Natl Acad Sci U S A 99(21):13753-8. [PubMed: 12361980]  [MGI Ref ID J:109851]

Marsden MD; Kovochich M; Suree N; Shimizu S; Mehta R; Cortado R; Bristol G; An DS; Zack JA. 2012. HIV Latency in the Humanized BLT Mouse. J Virol 86(1):339-47. [PubMed: 22072769]  [MGI Ref ID J:179389]

Masaki T; Qu J; Cholewa-Waclaw J; Burr K; Raaum R; Rambukkana A. 2013. Reprogramming adult Schwann cells to stem cell-like cells by leprosy bacilli promotes dissemination of infection. Cell 152(1-2):51-67. [PubMed: 23332746]  [MGI Ref ID J:214507]

Matsuoka K; Saito M; Shibata K; Sekine M; Shitara H; Taya C; Zhang X; Takahashi TA; Kohno K; Kikkawa Y; Yonekawa H. 2013. Generation of mouse models for type 1 diabetes by selective depletion of pancreatic beta cells using toxin receptor-mediated cell knockout. Biochem Biophys Res Commun 436(3):400-5. [PubMed: 23747725]  [MGI Ref ID J:204420]

McCool TL; Weiser JN. 2004. Limited role of antibody in clearance of Streptococcus pneumoniae in a murine model of colonization. Infect Immun 72(10):5807-13. [PubMed: 15385481]  [MGI Ref ID J:93131]

McDermott SP; Eppert K; Lechman ER; Doedens M; Dick JE. 2010. Comparison of human cord blood engraftment between immunocompromised mouse strains. Blood 116(2):193-200. [PubMed: 20404133]  [MGI Ref ID J:162809]

McIntosh BE; Brown ME; Duffin BM; Maufort JP; Vereide DT; Slukvin II; Thomson JA. 2015. Nonirradiated NOD,B6.SCID Il2rgamma(-/-)Kit(W41/W41) (NBSGW) Mice Support Multilineage Engraftment of Human Hematopoietic Cells. Stem Cell Reports 4(2):171-80. [PubMed: 25601207]  [MGI Ref ID J:218738]

Mehta S; Huillard E; Kesari S; Maire CL; Golebiowski D; Harrington EP; Alberta JA; Kane MF; Theisen M; Ligon KL; Rowitch DH; Stiles CD. 2011. The Central Nervous System-Restricted Transcription Factor Olig2 Opposes p53 Responses to Genotoxic Damage in Neural Progenitors and Malignant Glioma. Cancer Cell 19(3):359-71. [PubMed: 21397859]  [MGI Ref ID J:169930]

Meissner N; Swain S; McInnerney K; Han S; Harmsen AG. 2010. Type-I IFN signaling suppresses an excessive IFN-gamma response and thus prevents lung damage and chronic inflammation during pneumocystis (PC) clearance in CD4 T cell-competent mice. Am J Pathol 176(6):2806-18. [PubMed: 20395428]  [MGI Ref ID J:161163]

Meissner NN; Swain S; Tighe M; Harmsen A; Harmsen A. 2005. Role of type I IFNs in pulmonary complications of Pneumocystis murina infection. J Immunol 174(9):5462-71. [PubMed: 15843544]  [MGI Ref ID J:98407]

Miller RD; Hogg J; Ozaki JH; Gell D; Jackson SP; Riblet R. 1995. Gene for the catalytic subunit of mouse DNA-dependent protein kinase maps to the scid locus. Proc Natl Acad Sci U S A 92(23):10792-5. [PubMed: 7479885]  [MGI Ref ID J:29679]

Mishra R; Chen AT; Welsh RM; Szomolanyi-Tsuda E. 2010. NK cells and gammadelta T cells mediate resistance to polyomavirus-induced tumors. PLoS Pathog 6(5):e1000924. [PubMed: 20523894]  [MGI Ref ID J:162921]

Mizrahi K; Stein J; Pearl-Yafe M; Kaplan O; Yaniv I; Askenasy N. 2010. Regulatory functions of TRAIL in hematopoietic progenitors: human umbilical cord blood and murine bone marrow transplantation. Leukemia 24(7):1325-34. [PubMed: 20485377]  [MGI Ref ID J:162490]

Montecino-Rodriguez E; Leathers H; Dorshkind K. 2006. Identification of a B-1 B cell-specified progenitor. Nat Immunol 7(3):293-301. [PubMed: 16429139]  [MGI Ref ID J:112481]

Monteiro JP; Benjamin A; Costa ES; Barcinski MA; Bonomo A. 2005. Normal hematopoiesis is maintained by activated bone marrow CD4+ T cells. Blood 105(4):1484-91. [PubMed: 15514013]  [MGI Ref ID J:96600]

Morris SC; Heidorn SM; Herbert DR; Perkins C; Hildeman DA; Khodoun MV; Finkelman FD. 2009. Endogenously produced IL-4 nonredundantly stimulates CD8+ T cell proliferation. J Immunol 182(3):1429-38. [PubMed: 19155490]  [MGI Ref ID J:144327]

Morrison C; Smith GC; Stingl L; Jackson SP; Wagner EF; Wang ZQ. 1997. Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis. Nat Genet 17(4):479-82. [PubMed: 9398855]  [MGI Ref ID J:75374]

Mosier DE; Stell KL; Gulizia RJ; Torbett BE; Gilmore GL. 1993. Homozygous scid/scid;beige/beige mice have low levels of spontaneous or neonatal T cell-induced B cell generation. J Exp Med 177(1):191-4. [PubMed: 8418200]  [MGI Ref ID J:3479]

Mota J; Rico-Hesse R. 2009. Humanized mice show clinical signs of dengue fever according to infecting virus genotype. J Virol 83(17):8638-45. [PubMed: 19535452]  [MGI Ref ID J:153922]

Mustafi R; Dougherty U; Shah H; Dehghan H; Gliksberg A; Wu J; Zhu H; Joseph L; Hart J; Dive C; Fichera A; Threadgill D; Bissonnette M. 2012. Both stromal cell and colonocyte epidermal growth factor receptors control HCT116 colon cancer cell growth in tumor xenografts. Carcinogenesis 33(10):1930-9. [PubMed: 22791816]  [MGI Ref ID J:192954]

Mutwiri G K; Kosecka U; Benjamin M; Rosendal S; Perdue M; Butler D G. 2001. Mycobacterium avium subspecies paratuberculosis triggers intestinal pathophysiologic changes in beige/scid mice. Comp Med 51(6):538-44. [PubMed: 11924817]  [MGI Ref ID J:73720]

Nacht M; Strasser A; Chan YR; Harris AW; Schlissel M; Bronson RT; Jacks T. 1996. Mutations in the p53 and SCID genes cooperate in tumorigenesis. Genes Dev 10(16):2055-66. [PubMed: 8769648]  [MGI Ref ID J:35055]

Nakayama M; Beilke JN; Jasinski JM; Kobayashi M; Miao D; Li M; Coulombe MG; Liu E; Elliott JF; Gill RG; Eisenbarth GS. 2007. Priming and effector dependence on insulin B:9-23 peptide in NOD islet autoimmunity. J Clin Invest 117(7):1835-43. [PubMed: 17607359]  [MGI Ref ID J:124210]

Naramura M; Nandwani N; Gu H; Band V; Band H. 2010. Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells. Proc Natl Acad Sci U S A 107(37):16274-9. [PubMed: 20805496]  [MGI Ref ID J:164365]

Nemoto Y; Kanai T; Takahara M; Oshima S; Okamoto R; Tsuchiya K; Matsumoto S; Watanabe M. 2013. Th1/Th17-mediated interstitial pneumonia in chronic colitis mice independent of intestinal microbiota. J Immunol 190(12):6616-25. [PubMed: 23670188]  [MGI Ref ID J:204854]

Niimi N; Sugo N; Aratani Y; Koyama H. 2005. Genetic interaction between DNA polymerase beta and DNA-PKcs in embryogenesis and neurogenesis. Cell Death Differ 12(2):184-91. [PubMed: 15647757]  [MGI Ref ID J:106364]

Nishiyama Y; Hamada H; Nonaka S; Yamamoto H; Nanno M; Katayama Y; Takahashi H; Ishikawa H. 2002. Homeostatic regulation of intestinal villous epithelia by B lymphocytes. J Immunol 168(6):2626-33. [PubMed: 11884426]  [MGI Ref ID J:126867]

Nonaka S; Naito T; Chen H; Yamamoto M; Moro K; Kiyono H; Hamada H; Ishikawa H. 2005. Intestinal gammadelta T cells develop in mice lacking thymus, all lymph nodes, Peyer's patches, and isolated lymphoid follicles. J Immunol 174(4):1906-12. [PubMed: 15699117]  [MGI Ref ID J:96579]

Nonoyama S; Smith FO; Bernstein ID; Ochs HD. 1993. Strain-dependent leakiness of mice with severe combined immune deficiency. J Immunol 150(9):3817-24. [PubMed: 8473734]  [MGI Ref ID J:4610]

Noorchashm H; Reed AJ; Rostami SY; Mozaffari R; Zekavat G; Koeberlein B; Caton AJ; Naji A. 2006. B cell-mediated antigen presentation is required for the pathogenesis of acute cardiac allograft rejection. J Immunol 177(11):7715-22. [PubMed: 17114442]  [MGI Ref ID J:140848]

Notley CA; Inglis JJ; Alzabin S; McCann FE; McNamee KE; Williams RO. 2008. Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells. J Exp Med 205(11):2491-7. [PubMed: 18936235]  [MGI Ref ID J:140651]

O'Boyle G; Fox CR; Walden HR; Willet JD; Mavin ER; Hine DW; Palmer JM; Barker CE; Lamb CA; Ali S; Kirby JA. 2012. Chemokine receptor CXCR3 agonist prevents human T-cell migration in a humanized model of arthritic inflammation. Proc Natl Acad Sci U S A 109(12):4598-603. [PubMed: 22392992]  [MGI Ref ID J:182231]

O'Hara JR; Skinn AC; MacNaughton WK; Sherman PM; Sharkey KA. 2006. Consequences of Citrobacter rodentium infection on enteroendocrine cells and the enteric nervous system in the mouse colon. Cell Microbiol 8(4):646-60. [PubMed: 16548890]  [MGI Ref ID J:135756]

O'Malley JT; Eri RD; Stritesky GL; Mathur AN; Chang HC; Hogenesch H; Srinivasan M; Kaplan MH. 2008. STAT4 isoforms differentially regulate Th1 cytokine production and the severity of inflammatory bowel disease. J Immunol 181(7):5062-70. [PubMed: 18802110]  [MGI Ref ID J:142733]

O'Reilly LA; Harris AW; Strasser A. 1997. bcl-2 transgene expression promotes survival and reduces proliferation of CD3-CD4-CD8- T cell progenitors. Int Immunol 9(9):1291-301. [PubMed: 9310832]  [MGI Ref ID J:93122]

O'Reilly LA; Harris AW; Tarlinton DM; Corcoran LM; Strasser A. 1997. Expression of a bcl-2 transgene reduces proliferation and slows turnover of developing B lymphocytes in vivo. J Immunol 159(5):2301-11. [PubMed: 9278319]  [MGI Ref ID J:93123]

Ochiai M; Ubagai T; Kawamori T; Imai H; Sugimura T; Nakagama H. 2001. High susceptibility of Scid mice to colon carcinogenesis induced by azoxymethane indicates a possible caretaker role for DNA-dependent protein kinase. Carcinogenesis 22(9):1551-5. [PubMed: 11532879]  [MGI Ref ID J:84343]

Ohsugi T; Kiuchi Y; Shimoda K; Oguri S; Maejima K. 1996. Translocation of bacteria from the gastrointestinal tract in immunodeficient mice. Lab Anim 30(1):46-50. [PubMed: 8709573]  [MGI Ref ID J:31261]

Oida T; Suzuki K; Nanno M; Kanamori Y; Saito H; Kubota E; Kato S; Itoh M; Kaminogawa S; Ishikawa H. 2000. Role of gut cryptopatches in early extrathymic maturation of intestinal intraepithelial T cells. J Immunol 164(7):3616-26. [PubMed: 10725718]  [MGI Ref ID J:112139]

Okada K; Shoda J; Taguchi K; Maher JM; Ishizaki K; Inoue Y; Ohtsuki M; Goto N; Takeda K; Utsunomiya H; Oda K; Warabi E; Ishii T; Osaka K; Hyodo I; Yamamoto M. 2008. Ursodeoxycholic acid stimulates Nrf2-mediated hepatocellular transport, detoxification, and antioxidative stress systems in mice. Am J Physiol Gastrointest Liver Physiol 295(4):G735-47. [PubMed: 18687751]  [MGI Ref ID J:142149]

Okazaki T; Okazaki IM; Wang J; Sugiura D; Nakaki F; Yoshida T; Kato Y; Fagarasan S; Muramatsu M; Eto T; Hioki K; Honjo T. 2011. PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice. J Exp Med 208(2):395-407. [PubMed: 21300912]  [MGI Ref ID J:176845]

Okazuka K; Wakabayashi Y; Kashihara M; Inoue J; Sato T; Yokoyama M; Aizawa S; Aizawa Y; Mishima Y; Kominami R. 2005. p53 prevents maturation of T cell development to the immature CD4(-)CD8(+) stage in Bcl11b(-/-) mice. Biochem Biophys Res Commun 328(2):545-549. [PubMed: 15694382]  [MGI Ref ID J:96179]

Omori K; Mitsuhashi M; Ishiyama K; Nair I; Rawson J; Todorov I; Kandeel F; Mullen Y. 2011. mRNA of the pro-apoptotic gene BBC3 serves as a molecular marker for TNF-alpha-induced islet damage in humans. Diabetologia 54(8):2056-66. [PubMed: 21567299]  [MGI Ref ID J:175299]

Opata MM; Ye Z; Hollifield M; Garvy BA. 2013. B Cell Production of Tumor Necrosis Factor in Response to Pneumocystis murina Infection in Mice. Infect Immun 81(11):4252-60. [PubMed: 24002064]  [MGI Ref ID J:201876]

Origanti S; Cai SR; Munir AZ; White LS; Piwnica-Worms H. 2013. Synthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cells. Oncogene 32(5):577-88. [PubMed: 22430210]  [MGI Ref ID J:193369]

Osmond DG; Kim N; Manoukian R; Phillips RA; Rico-Vargas SA; Jacobsen K. 1992. Dynamics and localization of early B-lymphocyte precursor cells (pro-B cells) in the bone marrow of scid mice. Blood 79(7):1695-703. [PubMed: 1373084]  [MGI Ref ID J:737]

Owyang AM; Zaph C; Wilson EH; Guild KJ; McClanahan T; Miller HR; Cua DJ; Goldschmidt M; Hunter CA; Kastelein RA; Artis D. 2006. Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract. J Exp Med 203(4):843-9. [PubMed: 16606667]  [MGI Ref ID J:123808]

Ozaki H; Mori K; Nakagawa Y; Hoshikawa S; Ito S; Inoue Y; Takai T; Yoshida K. 2009. Autoimmune thyroiditis in Fcgamma receptor-deficient nonobese diabetic mice. Clin Immunol 132(2):291-3. [PubMed: 19447681]  [MGI Ref ID J:151452]

Paciorkowski N; Porte P; Shultz LD; Rajan TV. 2000. B1 B lymphocytes play a critical role in host protection against lymphatic filarial parasites. J Exp Med 191(4):731-6. [PubMed: 10684864]  [MGI Ref ID J:112016]

Paliwal P; Conboy IM. 2011. Inhibitors of tyrosine phosphatases and apoptosis reprogram lineage-marked differentiated muscle to myogenic progenitor cells. Chem Biol 18(9):1153-66. [PubMed: 21944754]  [MGI Ref ID J:190199]

Pancewicz J; Taylor JM; Datta A; Baydoun HH; Waldmann TA; Hermine O; Nicot C. 2010. Notch signaling contributes to proliferation and tumor formation of human T-cell leukemia virus type 1-associated adult T-cell leukemia. Proc Natl Acad Sci U S A 107(38):16619-24. [PubMed: 20823234]  [MGI Ref ID J:164350]

Papagiannakopoulos T; Friedmann-Morvinski D; Neveu P; Dugas JC; Gill RM; Huillard E; Liu C; Zong H; Rowitch DH; Barres BA; Verma IM; Kosik KS. 2012. Pro-neural miR-128 is a glioma tumor suppressor that targets mitogenic kinases. Oncogene 31(15):1884-95. [PubMed: 21874051]  [MGI Ref ID J:186143]

Papeta N; Zheng Z; Schon EA; Brosel S; Altintas MM; Nasr SH; Reiser J; D'Agati VD; Gharavi AG. 2010. Prkdc participates in mitochondrial genome maintenance and prevents Adriamycin-induced nephropathy in mice. J Clin Invest 120(11):4055-64. [PubMed: 20978358]  [MGI Ref ID J:166909]

Park CW; Ryu HW; Ryu KY. 2012. Locus coeruleus neurons are resistant to dysfunction and degeneration by maintaining free ubiquitin levels although total ubiquitin levels decrease upon disruption of polyubiquitin gene Ubb. Biochem Biophys Res Commun 418(3):541-6. [PubMed: 22285186]  [MGI Ref ID J:181255]

Pauza ME; Dobbs CM; He J; Patterson T; Wagner S; Anobile BS; Bradley BJ; Lo D; Haskins K. 2004. T-cell receptor transgenic response to an endogenous polymorphic autoantigen determines susceptibility to diabetes. Diabetes 53(4):978-88. [PubMed: 15047613]  [MGI Ref ID J:89082]

Pearson T; Greiner DL; Shultz LD. 2008. Creation of 'humanized' mice to study human immunity. Curr Protoc Immunol Chapter 15:Unit 15.21. [PubMed: 18491294]  [MGI Ref ID J:151386]

Pearson T; Shultz LD; Lief J; Burzenski L; Gott B; Chase T; Foreman O; Rossini AA; Bottino R; Trucco M; Greiner DL. 2008. A new immunodeficient hyperglycaemic mouse model based on the Ins2 ( Akita ) mutation for analyses of human islet and beta stem and progenitor cell function. Diabetologia 51(8):1449-56. [PubMed: 18563383]  [MGI Ref ID J:138005]

Pearson T; Shultz LD; Miller D; King M; Laning J; Fodor W; Cuthbert A; Burzenski L; Gott B; Lyons B; Foreman O; Rossini AA; Greiner DL. 2008. Non-obese diabetic-recombination activating gene-1 (NOD-Rag1 null) interleukin (IL)-2 receptor common gamma chain (IL2r gamma null) null mice: a radioresistant model for human lymphohaematopoietic engraftment. Clin Exp Immunol 154(2):270-84. [PubMed: 18785974]  [MGI Ref ID J:140388]

Pedraza-Alva G; Koulnis M; Charland C; Thornton T; Clements JL; Schlissel MS; Rincon M. 2006. Activation of p38 MAP kinase by DNA double-strand breaks in V(D)J recombination induces a G2/M cell cycle checkpoint. EMBO J 25(4):763-73. [PubMed: 16456545]  [MGI Ref ID J:105987]

Pei Y; Moore CE; Wang J; Tewari AK; Eroshkin A; Cho YJ; Witt H; Korshunov A; Read TA; Sun JL; Schmitt EM; Miller CR; Buckley AF; McLendon RE; Westbrook TF; Northcott PA; Taylor MD; Pfister SM; Febbo PG; Wechsler-Reya RJ. 2012. An Animal Model of MYC-Driven Medulloblastoma. Cancer Cell 21(2):155-67. [PubMed: 22340590]  [MGI Ref ID J:181463]

Percy DH; Auger DC; Croy BA. 1994. Signs and lesions of experimental Sendai virus infection in two genetically distinct strains of SCID/beige mice. Vet Pathol 31(1):67-73. [PubMed: 8140728]  [MGI Ref ID J:17913]

Percy DH; Barta JR. 1993. Spontaneous and experimental infections in scid and scid/beige mice. Lab Anim Sci 43(2):127-32. [PubMed: 8320959]  [MGI Ref ID J:4752]

Perone MJ; Bertera S; Tawadrous ZS; Shufesky WJ; Piganelli JD; Baum LG; Trucco M; Morelli AE. 2006. Dendritic cells expressing transgenic galectin-1 delay onset of autoimmune diabetes in mice. J Immunol 177(8):5278-89. [PubMed: 17015713]  [MGI Ref ID J:139444]

Petitto JM; Huang Z; Lo J; Streit WJ. 2003. IL-2 gene knockout affects T lymphocyte trafficking and the microglial response to regenerating facial motor neurons. J Neuroimmunol 134(1-2):95-103. [PubMed: 12507776]  [MGI Ref ID J:105891]

Phillips JM; Parish NM; Drage M; Cooke A. 2001. Cutting edge: interactions through the IL-10 receptor regulate autoimmune diabetes. J Immunol 167(11):6087-91. [PubMed: 11714766]  [MGI Ref ID J:119045]

Pierce EM; Carpenter K; Jakubzick C; Kunkel SL; Flaherty KR; Martinez FJ; Hogaboam CM. 2007. Therapeutic targeting of CC ligand 21 or CC chemokine receptor 7 abrogates pulmonary fibrosis induced by the adoptive transfer of human pulmonary fibroblasts to immunodeficient mice. Am J Pathol 170(4):1152-64. [PubMed: 17392156]  [MGI Ref ID J:120124]

Pierce MA; Chapman HD; Post CM; Svetlanov A; Efrat S; Horwitz M; Serreze DV. 2003. Adenovirus early region 3 antiapoptotic 10.4K, 14.5K, and 14.7K genes decrease the incidence of autoimmune diabetes in NOD mice. Diabetes 52(5):1119-27. [PubMed: 12716741]  [MGI Ref ID J:83195]

Porubsky S; Wang S; Kiss E; Dehmel S; Bonrouhi M; Dorn T; Luckow B; Brakebusch C; Grone HJ. 2011. Rhoh deficiency reduces peripheral T-cell function and attenuates allogenic transplant rejection. Eur J Immunol 41(1):76-88. [PubMed: 21182079]  [MGI Ref ID J:174659]

Powrie F; Leach MW; Mauze S; Menon S; Caddle LB; Coffman RL. 1994. Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells. Immunity 1(7):553-62. [PubMed: 7600284]  [MGI Ref ID J:133778]

Prochazka M; Gaskins HR; Shultz LD; Leiter EH. 1992. The nonobese diabetic scid mouse: model for spontaneous thymomagenesis associated with immunodeficiency. Proc Natl Acad Sci U S A 89(8):3290-4. [PubMed: 1373493]  [MGI Ref ID J:513]

Qing Y; Lin Y; Gerson SL. 2012. An intrinsic BM hematopoietic niche occupancy defect of HSC in scid mice facilitates exogenous HSC engraftment. Blood 119(7):1768-71. [PubMed: 22147896]  [MGI Ref ID J:181738]

Qualls JE; Kaplan AM; van Rooijen N; Cohen DA. 2006. Suppression of experimental colitis by intestinal mononuclear phagocytes. J Leukoc Biol 80(4):802-15. [PubMed: 16888083]  [MGI Ref ID J:113033]

Quintana E; Shackleton M; Sabel MS; Fullen DR; Johnson TM; Morrison SJ. 2008. Efficient tumour formation by single human melanoma cells. Nature 456(7222):593-8. [PubMed: 19052619]  [MGI Ref ID J:142408]

Rappa G; Mercapide J; Lorico A. 2012. Spontaneous Formation of Tumorigenic Hybrids between Breast Cancer and Multipotent Stromal Cells Is a Source of Tumor Heterogeneity. Am J Pathol 180(6):2504-15. [PubMed: 22542847]  [MGI Ref ID J:184798]

Rauch DA; Hurchla MA; Harding JC; Deng H; Shea LK; Eagleton MC; Niewiesk S; Lairmore MD; Piwnica-Worms D; Rosol TJ; Weber JD; Ratner L; Weilbaecher KN. 2010. The ARF tumor suppressor regulates bone remodeling and osteosarcoma development in mice. PLoS One 5(12):e15755. [PubMed: 21209895]  [MGI Ref ID J:168312]

Rauner G; Leviav A; Mavor E; Barash I. 2013. Development of Foreign Mammary Epithelial Morphology in the Stroma of Immunodeficient Mice. PLoS One 8(6):e68637. [PubMed: 23825700]  [MGI Ref ID J:204342]

Read TA; Fogarty MP; Markant SL; McLendon RE; Wei Z; Ellison DW; Febbo PG; Wechsler-Reya RJ. 2009. Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma. Cancer Cell 15(2):135-47. [PubMed: 19185848]  [MGI Ref ID J:144811]

Riggs J; Stowers R. 1996. Ability of spleen, peritoneal cavity, and lymph node B cells to reconstitute serum immunoglobulin in SCID mice. Immunology 88(1):20-7. [PubMed: 8707345]  [MGI Ref ID J:32916]

Riggs JE; Feeney AJ; Kirven M; Mosier DE. 1994. VH11 bias and normal V-D-J junctions in SCID B lymphocytes rescued by neonatal T cell transfer. Mol Immunol 31(11):783-91. [PubMed: 8047070]  [MGI Ref ID J:19789]

Rival C; Samy E; Setiady Y; Tung K. 2013. Cutting edge: Ly49C/I(-) neonatal NK cells predispose newborns to autoimmune ovarian disease induced by maternal autoantibody. J Immunol 191(6):2865-9. [PubMed: 23960238]  [MGI Ref ID J:205867]

Rivera J; Zaragoza O; Casadevall A. 2005. Antibody-mediated protection against Cryptococcus neoformans pulmonary infection is dependent on B cells. Infect Immun 73(2):1141-50. [PubMed: 15664957]  [MGI Ref ID J:95620]

Roberts JL; Abe R; Shores EW; Singer A. 1992. Expression of Mls determinants in mice exhibiting the severe combined immunodeficiency (scid) mutation or X-linked immunodeficiency (xid) defect. J Immunol 149(5):1577-82. [PubMed: 1506683]  [MGI Ref ID J:2072]

Rochford R; Ohrt C; Baresel PC; Campo B; Sampath A; Magill AJ; Tekwani BL; Walker LA. 2013. Humanized mouse model of glucose 6-phosphate dehydrogenase deficiency for in vivo assessment of hemolytic toxicity. Proc Natl Acad Sci U S A 110(43):17486-91. [PubMed: 24101478]  [MGI Ref ID J:201977]

Rodgers JT; King KY; Brett JO; Cromie MJ; Charville GW; Maguire KK; Brunson C; Mastey N; Liu L; Tsai CR; Goodell MA; Rando TA. 2014. mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert). Nature 510(7505):393-6. [PubMed: 24870234]  [MGI Ref ID J:213273]

Rolink A; Melchers F; Andersson J. 1996. The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching. Immunity 5(4):319-30. [PubMed: 8885865]  [MGI Ref ID J:36026]

Rosario CO; Ko MA; Haffani YZ; Gladdy RA; Paderova J; Pollett A; Squire JA; Dennis JW; Swallow CJ. 2010. Plk4 is required for cytokinesis and maintenance of chromosomal stability. Proc Natl Acad Sci U S A 107(15):6888-93. [PubMed: 20348415]  [MGI Ref ID J:159310]

Roths JB; Smith AL; Sidman CL. 1993. Lethal exacerbation of Pneumocystis carinii pneumonia in severe combined immunodeficiency mice after infection by pneumonia virus of mice. J Exp Med 177(4):1193-8. [PubMed: 8459214]  [MGI Ref ID J:109921]

Rotolo JA; Mesicek J; Maj J; Truman JP; Haimovitz-Friedman A; Kolesnick R; Fuks Z. 2010. Regulation of ceramide synthase-mediated crypt epithelium apoptosis by DNA damage repair enzymes. Cancer Res 70(3):957-67. [PubMed: 20086180]  [MGI Ref ID J:156862]

Ruan S; McKinley L; Zheng M; Rudner X; D'Souza A; Kolls JK; Shellito JE. 2008. Interleukin-12 and host defense against murine Pneumocystis pneumonia. Infect Immun 76(5):2130-7. [PubMed: 18332204]  [MGI Ref ID J:134470]

Ruetsch NR; Bosma GC; Bosma MJ. 2000. Unexpected rearrangement and expression of the immunoglobulin lambda1 locus in scid mice. J Exp Med 191(11):1933-43. [PubMed: 10839808]  [MGI Ref ID J:62701]

Rynda-Apple A; Dobrinen E; McAlpine M; Read A; Harmsen A; Richert LE; Calverley M; Pallister K; Voyich J; Wiley JA; Johnson B; Young M; Douglas T; Harmsen AG. 2012. Virus-Like Particle-Induced Protection Against MRSA Pneumonia Is Dependent on IL-13 and Enhancement of Phagocyte Function. Am J Pathol 181(1):196-210. [PubMed: 22642909]  [MGI Ref ID J:185523]

Salem ML; Al-Khami AA; El-Naggar SA; Diaz-Montero CM; Chen Y; Cole DJ. 2010. Cyclophosphamide induces dynamic alterations in the host microenvironments resulting in a Flt3 ligand-dependent expansion of dendritic cells. J Immunol 184(4):1737-47. [PubMed: 20083664]  [MGI Ref ID J:159482]

Samy ET; Meyer CA; Caplazi P; Langrish CL; Lora JM; Bluethmann H; Peng SL. 2007. Cutting edge: Modulation of intestinal autoimmunity and IL-2 signaling by sphingosine kinase 2 independent of sphingosine 1-phosphate. J Immunol 179(9):5644-8. [PubMed: 17947634]  [MGI Ref ID J:153014]

Santidrian AF; Matsuno-Yagi A; Ritland M; Seo BB; LeBoeuf SE; Gay LJ; Yagi T; Felding-Habermann B. 2013. Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression. J Clin Invest 123(3):1068-81. [PubMed: 23426180]  [MGI Ref ID J:196392]

Saville SP; Lazzell AL; Chaturvedi AK; Monteagudo C; Lopez-Ribot JL. 2008. Use of a genetically engineered strain to evaluate the pathogenic potential of yeast cell and filamentous forms during Candida albicans systemic infection in immunodeficient mice. Infect Immun 76(1):97-102. [PubMed: 17967861]  [MGI Ref ID J:130296]

Savinov AY; Rozanov DV; Strongin AY. 2007. Specific inhibition of autoimmune T cell transmigration contributes to beta cell functionality and insulin synthesis in non-obese diabetic (NOD) mice. J Biol Chem 282(44):32106-11. [PubMed: 17761671]  [MGI Ref ID J:126809]

Savinov AY; Tcherepanov A; Green EA; Flavell RA; Chervonsky AV. 2003. Contribution of Fas to diabetes development. Proc Natl Acad Sci U S A 100(2):628-32. [PubMed: 12525697]  [MGI Ref ID J:81416]

Savouret C; Brisson E; Essers J; Kanaar R; Pastink A; te Riele H; Junien C; Gourdon G. 2003. CTG repeat instability and size variation timing in DNA repair-deficient mice. EMBO J 22(9):2264-73. [PubMed: 12727892]  [MGI Ref ID J:83373]

Scheeren FA; Kuo AH; van Weele LJ; Cai S; Glykofridis I; Sikandar SS; Zabala M; Qian D; Lam JS; Johnston D; Volkmer JP; Sahoo D; van de Rijn M; Dirbas FM; Somlo G; Kalisky T; Rothenberg ME; Quake SR; Clarke MF. 2014. A cell-intrinsic role for TLR2-MYD88 in intestinal and breast epithelia and oncogenesis. Nat Cell Biol 16(12):1238-48. [PubMed: 25362351]  [MGI Ref ID J:217693]

Schito ML; Barta JR. 1997. Nonspecific immune responses and mechanisms of resistance to Eimeria papillata infections in mice. Infect Immun 65(8):3165-70. [PubMed: 9234770]  [MGI Ref ID J:41839]

Schmidt RE; Dorsey DA; Beaudet LN; Frederick KE; Parvin CA; Plurad SB; Levisetti MG. 2003. Non-obese diabetic mice rapidly develop dramatic sympathetic neuritic dystrophy: a new experimental model of diabetic autonomic neuropathy. Am J Pathol 163(5):2077-91. [PubMed: 14578206]  [MGI Ref ID J:86318]

Schon MP; Schon M; Warren HB; Donohue JP; Parker CM. 2000. Cutaneous inflammatory disorder in integrin alphaE (CD103)-deficient mice. J Immunol 165(11):6583-9. [PubMed: 11086102]  [MGI Ref ID J:110810]

Schroder PM; Khattar M; Baum CE; Miyahara Y; Chen W; Vyas R; Muralidharan S; Mierzejewska B; Stepkowski SM. 2015. PD-1-dependent restoration of self-tolerance in the NOD mouse model of diabetes after transient anti-TCRbeta mAb therapy. Diabetologia 58(6):1309-18. [PubMed: 25794782]  [MGI Ref ID J:220839]

Schuler W; Weiler IJ; Schuler A; Phillips RA; Rosenberg N; Mak TW; Kearney JF; Perry RP; Bosma MJ. 1986. Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency. Cell 46(7):963-72. [PubMed: 3093081]  [MGI Ref ID J:8420]

Searles S; Gauss K; Wilkison M; Hoyt TR; Dobrinen E; Meissner N. 2013. Modulation of inflammasome-mediated pulmonary immune activation by type I IFNs protects bone marrow homeostasis during systemic responses to Pneumocystis lung infection. J Immunol 191(7):3884-95. [PubMed: 23975863]  [MGI Ref ID J:205844]

Seif AE; Barrett DM; Milone M; Brown VI; Grupp SA; Reid GS. 2009. Long-term protection from syngeneic acute lymphoblastic leukemia by CpG ODN-mediated stimulation of innate and adaptive immune responses. Blood 114(12):2459-66. [PubMed: 19636062]  [MGI Ref ID J:152910]

Sekiguchi J; Ferguson DO; Chen HT; Yang EM; Earle J; Frank K; Whitlow S; Gu Y; Xu Y; Nussenzweig A; Alt FW. 2001. Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development. Proc Natl Acad Sci U S A 98(6):3243-8. [PubMed: 11248063]  [MGI Ref ID J:68074]

Sela U; Olds P; Park A; Schlesinger SJ; Steinman RM. 2011. Dendritic cells induce antigen-specific regulatory T cells that prevent graft versus host disease and persist in mice. J Exp Med 208(12):2489-96. [PubMed: 22084406]  [MGI Ref ID J:178615]

Serpe CJ; Kohm AP; Huppenbauer CB; Sanders VM; Jones KJ. 1999. Exacerbation of facial motoneuron loss after facial nerve transection in severe combined immunodeficient (scid) mice. J Neurosci 19(11):RC7. [PubMed: 10341268]  [MGI Ref ID J:120563]

Serreze DV; Chapman HD; Varnum DS; Gerling I; Leiter EH; Shultz LD. 1997. Initiation of autoimmune diabetes in NOD/Lt mice is MHC class I-dependent. J Immunol 158(8):3978-86. [PubMed: 9103469]  [MGI Ref ID J:39473]

Serreze DV; Johnson EA; Chapman HD; Graser RT; Marron MP; DiLorenzo TP; Silveira P; Yoshimura Y; Nathenson SG; Joyce S. 2001. Autoreactive diabetogenic T-cells in NOD mice can efficiently expand from a greatly reduced precursor pool. Diabetes 50(9):1992-2000. [PubMed: 11522664]  [MGI Ref ID J:71050]

Serreze DV; Leiter EH; Hanson MS; Christianson SW; Shultz LD; Hesselton RM; Greiner DL. 1995. Emv30null NOD-scid mice. An improved host for adoptive transfer of autoimmune diabetes and growth of human lymphohematopoietic cells. Diabetes 44(12):1392-8. [PubMed: 7589844]  [MGI Ref ID J:29951]

Severe S; Gauvrit A; Vu AT; Bach JM. 2007. CD8(+) T lymphocytes specific for glutamic acid decarboxylase 90-98 epitope mediate diabetes in NOD(SCID) mouse. Mol Immunol 44(11):2950-60. [PubMed: 17336387]  [MGI Ref ID J:119811]

Shang L; Hua H; Foo K; Martinez H; Watanabe K; Zimmer M; Kahler DJ; Freeby M; Chung W; LeDuc C; Goland R; Leibel RL; Egli D. 2014. beta-cell dysfunction due to increased ER stress in a stem cell model of Wolfram syndrome. Diabetes 63(3):923-33. [PubMed: 24227685]  [MGI Ref ID J:208989]

Shellito JE; Kolls JK; Olariu R; Beck JM. 1996. Nitric oxide and host defense against Pneumocystis carinii infection in a mouse model. J Infect Dis 173(2):432-9. [PubMed: 8568306]  [MGI Ref ID J:31163]

Shibata S; Asano T; Ogura A; Hashimoto N; Hayakawa J; Uetsuka K ; Nakayama H ; Doi K. 1997. SCID-bg mice as xenograft recipients. Lab Anim 31(2):163-8. [PubMed: 9175014]  [MGI Ref ID J:40569]

Shoji S; Watanabe H; Katoh O; Masaoka Y; Matsuura S; Tauchi H; Endo S; Komatsu K. 1998. Developmental malformations and intrauterine deaths in gamma-ray-irradiated scid mouse embryos. Int J Radiat Biol 73(6):705-9. [PubMed: 9690689]  [MGI Ref ID J:51083]

Shores EW; Nakayama T; Wiest DL; Takahama Y; Sharrow S; Singer A. 1993. Structurally distinct T cell receptor complexes on developmentally distinct T cell populations in severe combined immunodeficiency mice expressing a TCR beta transgene. J Immunol 150(4):1263-75. [PubMed: 8094405]  [MGI Ref ID J:111476]

Shultz LD; Banuelos S; Lyons B; Samuels R; Burzenski L; Gott B; Lang P; Leif J; Appel M; Rossini A; Greiner DL. 2003. NOD/LtSz-Rag1nullPfpnull mice: a new model system with increased levels of human peripheral leukocyte and hematopoietic stem-cell engraftment. Transplantation 76(7):1036-42. [PubMed: 14557749]  [MGI Ref ID J:109843]

Shultz LD; Ishikawa F; Greiner DL. 2007. Humanized mice in translational biomedical research. Nat Rev Immunol 7(2):118-30. [PubMed: 17259968]  [MGI Ref ID J:142414]

Shultz LD; Lyons BL; Burzenski LM; Gott B; Chen X; Chaleff S; Kotb M; Gillies SD; King M; Mangada J; Greiner DL; Handgretinger R. 2005. Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells. J Immunol 174(10):6477-89. [PubMed: 15879151]  [MGI Ref ID J:109833]

Shultz LD; Saito Y; Najima Y; Tanaka S; Ochi T; Tomizawa M; Doi T; Sone A; Suzuki N; Fujiwara H; Yasukawa M; Ishikawa F. 2010. Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r gamma(null) humanized mice. Proc Natl Acad Sci U S A 107(29):13022-7. [PubMed: 20615947]  [MGI Ref ID J:162315]

Shultz LD; Schweitzer PA; Christianson SW; Gott B; Schweitzer IB; Tennent B; McKenna S; Mobraaten L; Rajan TV; Greiner DL; Leiter EH. 1995. Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice. J Immunol 154(1):180-91. [PubMed: 7995938]  [MGI Ref ID J:22026]

Shurin MR; Potapovich AI; Tyurina YY; Tourkova IL; Shurin GV; Kagan VE. 2009. Recognition of live phosphatidylserine-labeled tumor cells by dendritic cells: a novel approach to immunotherapy of skin cancer. Cancer Res 69(6):2487-96. [PubMed: 19276376]  [MGI Ref ID J:147072]

Simard C; Klein SJ; Mak T; Jolicoeur P. 1997. Studies of the susceptibility of nude, CD4 knockout, and SCID mutant mice to the disease induced by the murine AIDS defective virus. J Virol 71(4):3013-22. [PubMed: 9060661]  [MGI Ref ID J:38897]

Simons BW; Hurley PJ; Huang Z; Ross AE; Miller R; Marchionni L; Berman DM; Schaeffer EM. 2012. Wnt signaling though beta-catenin is required for prostate lineage specification. Dev Biol 371(2):246-55. [PubMed: 22960283]  [MGI Ref ID J:190538]

Simpson-Abelson MR; Sonnenberg GF; Takita H; Yokota SJ; Conway TF Jr; Kelleher RJ Jr; Shultz LD; Barcos M; Bankert RB. 2008. Long-term engraftment and expansion of tumor-derived memory T cells following the implantation of non-disrupted pieces of human lung tumor into NOD-scid IL2Rgamma(null) mice. J Immunol 180(10):7009-18. [PubMed: 18453623]  [MGI Ref ID J:142412]

Smythies LE; Waites KB; Lindsey JR; Harris PR; Ghiara P; Smith PD. 2000. Helicobacter pylori-induced mucosal inflammation is Th1 mediated and exacerbated in IL-4, but not IFN-gamma, gene-deficient mice. J Immunol 165(2):1022-9. [PubMed: 10878379]  [MGI Ref ID J:120556]

Song X; Guo Y; Duo S; Che J; Wu C; Ochiya T; Ding M; Deng H. 2009. A mouse model of inducible liver injury caused by tet-on regulated urokinase for studies of hepatocyte transplantation. Am J Pathol 175(5):1975-83. [PubMed: 19808649]  [MGI Ref ID J:154703]

Spranger S; Jeremias I; Wilde S; Leisegang M; Starck L; Mosetter B; Uckert W; Heemskerk MH; Schendel DJ; Frankenberger B. 2012. TCR-transgenic lymphocytes specific for HMMR/Rhamm limit tumor outgrowth in vivo. Blood 119(15):3440-9. [PubMed: 22371883]  [MGI Ref ID J:183769]

Stalder AK; Carson MJ; Pagenstecher A; Asensio VC; Kincaid C; Benedict M; Powell HC; Masliah E; Campbell IL. 1998. Late-onset chronic inflammatory encephalopathy in immune-competent and severe combined immune-deficient (SCID) mice with astrocyte-targeted expression of tumor necrosis factor. Am J Pathol 153(3):767-83. [PubMed: 9736027]  [MGI Ref ID J:106595]

Stokes KY; Calahan L; Hamric CM; Russell JM; Granger DN. 2009. CD40/CD40L contributes to hypercholesterolemia-induced microvascular inflammation. Am J Physiol Heart Circ Physiol 296(3):H689-97. [PubMed: 19112095]  [MGI Ref ID J:146361]

Stone JL; McMillan RE; Skaar DA; Bradshaw JM; Jirtle RL; Sikes ML. 2012. DNA Double-Strand Breaks Relieve USF-Mediated Repression of Dbeta2 Germline Transcription in Developing Thymocytes. J Immunol 188(5):2266-75. [PubMed: 22287717]  [MGI Ref ID J:181246]

Stracker TH; Couto SS; Cordon-Cardo C; Matos T; Petrini JH. 2008. Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage. Mol Cell 31(1):21-32. [PubMed: 18614044]  [MGI Ref ID J:138550]

Stracker TH; Williams BR; Deriano L; Theunissen JW; Adelman CA; Roth DB; Petrini JH. 2009. Artemis and nonhomologous end joining-independent influence of DNA-dependent protein kinase catalytic subunit on chromosome stability. Mol Cell Biol 29(2):503-14. [PubMed: 19015239]  [MGI Ref ID J:144749]

Strasser A; Harris AW; Corcoran LM; Cory S. 1994. Bcl-2 expression promotes B- but not T-lymphoid development in scid mice. Nature 368(6470):457-60. [PubMed: 8133891]  [MGI Ref ID J:17426]

Stratford EW; Bostad M; Castro R; Skarpen E; Berg K; Hogset A; Myklebost O; Selbo PK. 2013. Photochemical internalization of CD133-targeting immunotoxins efficiently depletes sarcoma cells with stem-like properties and reduces tumorigenicity. Biochim Biophys Acta 1830(8):4235-43. [PubMed: 23643966]  [MGI Ref ID J:202381]

Strowig T; Chijioke O; Carrega P; Arrey F; Meixlsperger S; Ramer PC; Ferlazzo G; Munz C. 2010. Human NK cells of mice with reconstituted human immune system components require preactivation to acquire functional competence. Blood 116(20):4158-67. [PubMed: 20671122]  [MGI Ref ID J:167434]

Su MA; Davini D; Cheng P; Giang K; Fan U; DeVoss JJ; Johannes KP; Taylor L; Shum AK; Valenzise M; Meloni A; Bour-Jordan H; Anderson MS. 2012. Defective autoimmune regulator-dependent central tolerance to myelin protein zero is linked to autoimmune peripheral neuropathy. J Immunol 188(10):4906-12. [PubMed: 22490868]  [MGI Ref ID J:188686]

Su X; Hu Q; Kristan JM; Costa C; Shen Y; Gero D; Matis LA; Wang Y. 2000. Significant role for Fas in the pathogenesis of autoimmune diabetes. J Immunol 164(5):2523-32. [PubMed: 10679090]  [MGI Ref ID J:127009]

Suffia I; Reckling SK; Salay G; Belkaid Y. 2005. A role for CD103 in the retention of CD4+CD25+ Treg and control of Leishmania major infection. J Immunol 174(9):5444-55. [PubMed: 15845457]  [MGI Ref ID J:98414]

Sugiarto S; Persson AI; Munoz EG; Waldhuber M; Lamagna C; Andor N; Hanecker P; Ayers-Ringler J; Phillips J; Siu J; Lim DA; Vandenberg S; Stallcup W; Berger MS; Bergers G; Weiss WA; Petritsch C. 2011. Asymmetry-defective oligodendrocyte progenitors are glioma precursors. Cancer Cell 20(3):328-40. [PubMed: 21907924]  [MGI Ref ID J:175969]

Sugiura K; Taketani S; Yoshimura T; Nishino T; Nishino N; Fujisawa J; Hisha H; Inaba T; Ikehara S. 2007. Effect of hepatocyte growth factor on long term hematopoiesis of human progenitor cells in transgenic-severe combined immunodeficiency mice. Cytokine 37(3):218-26. [PubMed: 17512212]  [MGI Ref ID J:126823]

Sun X; Robertson SA; Ingman WV. 2013. Regulation of epithelial cell turnover and macrophage phenotype by epithelial cell-derived transforming growth factor beta1 in the mammary gland. Cytokine 61(2):377-88. [PubMed: 23290315]  [MGI Ref ID J:197873]

Sundberg JP (ed.). 1994. Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. In: Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. CRC Press, Boca Raton.  [MGI Ref ID J:30359]

Sundberg JP; Adkison DL; Bedigian HG. 1991. Skeletal muscle rhabdomyosarcomas in inbred laboratory mice. Vet Pathol 28(3):200-6. [PubMed: 1830433]  [MGI Ref ID J:24311]

Swaims AY; Khani F; Zhang Y; Roberts AI; Devadas S; Shi Y; Rabson AB. 2010. Immune activation induces immortalization of HTLV-1 LTR-Tax transgenic CD4+ T cells. Blood 116(16):2994-3003. [PubMed: 20634377]  [MGI Ref ID J:165866]

Swain SD; Siemsen DW; Pullen RR; Han S. 2014. CD4+ T cells and IFN-gamma are required for the development of Pneumocystis-associated pulmonary hypertension. Am J Pathol 184(2):483-93. [PubMed: 24361497]  [MGI Ref ID J:206386]

Szomolanyi-Tsuda E; Dundon PL; Joris I; Shultz LD; Woda BA; Welsh RM. 1994. Acute, lethal, natural killer cell-resistant myeloproliferative disease induced by polyomavirus in severe combined immunodeficient mice. Am J Pathol 144(2):359-71. [PubMed: 8311119]  [MGI Ref ID J:16875]

Ta VB; de Haan AB; de Bruijn MJ; Dingjan GM; Hendriks RW. 2011. Pre-B-cell leukemias in Btk/Slp65-deficient mice arise independently of ongoing V(D)J recombination activity. Leukemia 25(1):48-56. [PubMed: 21030983]  [MGI Ref ID J:167638]

Tadokoro Y; Ema H; Okano M; Li E; Nakauchi H. 2007. De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells. J Exp Med 204(4):715-22. [PubMed: 17420264]  [MGI Ref ID J:125606]

Takagi S; Saito Y; Hijikata A; Tanaka S; Watanabe T; Hasegawa T; Mochizuki S; Kunisawa J; Kiyono H; Koseki H; Ohara O; Saito T; Taniguchi S; Shultz LD; Ishikawa F. 2012. Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation. Blood :. [PubMed: 22279057]  [MGI Ref ID J:180274]

Takahama Y; Sugaya K; Tsuda S; Hasegawa T; Hashimoto Y. 1995. Regulation of early T cell development by the engagement of TCR-beta complex expressed on fetal thymocytes from TCR-beta-transgenic scid mice. J Immunol 154(11):5862-9. [PubMed: 7751632]  [MGI Ref ID J:25533]

Takahashi Y; Inamine A; Hashimoto S; Haraguchi S; Yoshioka E; Kojima N; Abe R; Takemori T. 2005. Novel role of the Ras cascade in memory B cell response. Immunity 23(2):127-38. [PubMed: 16111632]  [MGI Ref ID J:100532]

Takata M; Nakagomi T; Kashiwamura S; Nakano-Doi A; Saino O; Nakagomi N; Okamura H; Mimura O; Taguchi A; Matsuyama T. 2012. Glucocorticoid-induced TNF receptor-triggered T cells are key modulators for survival/death of neural stem/progenitor cells induced by ischemic stroke. Cell Death Differ 19(5):756-67. [PubMed: 22052192]  [MGI Ref ID J:203071]

Takenaka K; Prasolava TK; Wang JC; Mortin-Toth SM; Khalouei S; Gan OI; Dick JE; Danska JS. 2007. Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells. Nat Immunol 8(12):1313-23. [PubMed: 17982459]  [MGI Ref ID J:127760]

Takeuchi D; Jones VC; Kobayashi M; Suzuki F. 2008. Cooperative role of macrophages and neutrophils in host Antiprotozoan resistance in mice acutely infected with Cryptosporidium parvum. Infect Immun 76(8):3657-63. [PubMed: 18519557]  [MGI Ref ID J:139362]

Tanaka S; Saito Y; Kunisawa J; Kurashima Y; Wake T; Suzuki N; Shultz LD; Kiyono H; Ishikawa F. 2012. Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD/SCID/IL2rgammaKO mice. J Immunol 188(12):6145-55. [PubMed: 22611244]  [MGI Ref ID J:188959]

Thayer TC; Delano M; Liu C; Chen J; Padgett LE; Tse HM; Annamali M; Piganelli JD; Moldawer LL; Mathews CE. 2011. Superoxide production by macrophages and T cells is critical for the induction of autoreactivity and type 1 diabetes. Diabetes 60(8):2144-51. [PubMed: 21715554]  [MGI Ref ID J:186804]

The Jackson Laboratory. 2005. Information obtained from The Jackson Laboratory, Bar Harbor, ME Unpublished :.  [MGI Ref ID J:101977]

Thomas DC; Mellanby RJ; Phillips JM; Cooke A. 2007. An early age-related increase in the frequency of CD4+ Foxp3+ cells in BDC2.5NOD mice. Immunology 121(4):565-76. [PubMed: 17437531]  [MGI Ref ID J:125536]

Touvrey C; Couedel C; Soulas P; Couderc R; Jasin M; de Villartay JP; Marche PN; Jouvin-Marche E; Candeias SM. 2008. Distinct effects of DNA-PKcs and Artemis inactivation on signal joint formation in vivo. Mol Immunol 45(12):3383-91. [PubMed: 18501428]  [MGI Ref ID J:137712]

Tremblay AM; Missiaglia E; Galli GG; Hettmer S; Urcia R; Carrara M; Judson RN; Thway K; Nadal G; Selfe JL; Murray G; Calogero RA; De Bari C; Zammit PS; Delorenzi M; Wagers AJ; Shipley J; Wackerhage H; Camargo FD. 2014. The Hippo transducer YAP1 transforms activated satellite cells and is a potent effector of embryonal rhabdomyosarcoma formation. Cancer Cell 26(2):273-87. [PubMed: 25087979]  [MGI Ref ID J:214602]

Trowbridge JJ; Scott MP; Bhatia M. 2006. Hedgehog modulates cell cycle regulators in stem cells to control hematopoietic regeneration. Proc Natl Acad Sci U S A 103(38):14134-9. [PubMed: 16968775]  [MGI Ref ID J:113717]

Tsai S; Serra P; Clemente-Casares X; Slattery RM; Santamaria P. 2013. Dendritic cell-dependent in vivo generation of autoregulatory T cells by antidiabetogenic MHC class II. J Immunol 191(1):70-82. [PubMed: 23740949]  [MGI Ref ID J:205347]

Tsai S; Shameli A; Yamanouchi J; Clemente-Casares X; Wang J; Serra P; Yang Y; Medarova Z; Moore A; Santamaria P. 2010. Reversal of autoimmunity by boosting memory-like autoregulatory T cells. Immunity 32(4):568-80. [PubMed: 20381385]  [MGI Ref ID J:179859]

Tsuchiya T; Fukuda S; Hamada H; Nakamura A; Kohama Y; Ishikawa H; Tsujikawa K; Yamamoto H. 2003. Role of gamma delta T cells in the inflammatory response of experimental colitis mice. J Immunol 171(10):5507-13. [PubMed: 14607957]  [MGI Ref ID J:106734]

Tsuji H; Ishii-Ohba H; Noda Y; Kubo E; Furuse T; Tatsumi K. 2009. Rag-dependent and Rag-independent mechanisms of Notch1 rearrangement in thymic lymphomas of Atm(-/-) and scid mice. Mutat Res 660(1-2):22-32. [PubMed: 19000702]  [MGI Ref ID J:144042]

Tsuji Y; Watanabe T; Kudo M; Arai H; Strober W; Chiba T. 2012. Sensing of Commensal Organisms by the Intracellular Sensor NOD1 Mediates Experimental Pancreatitis. Immunity 37(2):326-38. [PubMed: 22902233]  [MGI Ref ID J:187368]

Tucker TA; Kundert JA; Bondareva AA; Schmidt EE. 2005. Reproductive and neurological Quakingviable phenotypes in a severe combined immune deficient mouse background. Immunogenetics 57(3-4):226-31. [PubMed: 15900494]  [MGI Ref ID J:98496]

Turley SJ; Lee JW; Dutton-Swain N; Mathis D; Benoist C. 2005. Endocrine self and gut non-self intersect in the pancreatic lymph nodes. Proc Natl Acad Sci U S A 102(49):17729-33. [PubMed: 16317068]  [MGI Ref ID J:104385]

Ueno S; Lu J; He J; Li A; Zhang X; Ritz J; Silberstein LE; Chai L. 2014. Aberrant expression of SALL4 in acute B cell lymphoblastic leukemia: mechanism, function, and implication for a potential novel therapeutic target. Exp Hematol 42(4):307-316.e8. [PubMed: 24463278]  [MGI Ref ID J:215705]

Uhlig HH; McKenzie BS; Hue S; Thompson C; Joyce-Shaikh B; Stepankova R; Robinson N; Buonocore S; Tlaskalova-Hogenova H; Cua DJ; Powrie F. 2006. Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology. Immunity 25(2):309-18. [PubMed: 16919486]  [MGI Ref ID J:113470]

Unsinger J; McDonough JS; Shultz LD; Ferguson TA; Hotchkiss RS. 2009. Sepsis-induced human lymphocyte apoptosis and cytokine production in 'humanized' mice. J Leukoc Biol 86(2):219-27. [PubMed: 19369639]  [MGI Ref ID J:151270]

Van Buul PP; De Rooij DG; Zandman IM; Grigorova M; Van Duyn-Goedhart A. 1995. X-ray-induced chromosomal aberrations and cell killing in somatic and germ cells of the scid mouse. Int J Radiat Biol 67(5):549-55. [PubMed: 7775830]  [MGI Ref ID J:26914]

VanBuskirk KM; O'Neill MT; De La Vega P; Maier AG; Krzych U; Williams J; Dowler MG; Sacci JB Jr; Kangwanrangsan N; Tsuboi T; Kneteman NM; Heppner DG Jr; Murdock BA; Mikolajczak SA; Aly AS; Cowman AF; Kappe SH. 2009. Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design. Proc Natl Acad Sci U S A 106(31):13004-9. [PubMed: 19625622]  [MGI Ref ID J:152010]

Vanner RJ; Remke M; Gallo M; Selvadurai HJ; Coutinho F; Lee L; Kushida M; Head R; Morrissy S; Zhu X; Aviv T; Voisin V; Clarke ID; Li Y; Mungall AJ; Moore RA; Ma Y; Jones SJ; Marra MA; Malkin D; Northcott PA; Kool M; Pfister SM; Bader G; Hochedlinger K; Korshunov A; Taylor MD; Dirks PB. 2014. Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma. Cancer Cell 26(1):33-47. [PubMed: 24954133]  [MGI Ref ID J:213713]

Vemuri MC; Schiller E; Naegele JR. 2001. Elevated DNA double strand breaks and apoptosis in the CNS of scid mutant mice. Cell Death Differ 8(3):245-55. [PubMed: 11319607]  [MGI Ref ID J:115402]

Verma-Gandhu M; Bercik P; Motomura Y; Verdu EF; Khan WI; Blennerhassett PA; Wang L; El-Sharkawy RT; Collins SM. 2006. CD4+ T-cell modulation of visceral nociception in mice. Gastroenterology 130(6):1721-8. [PubMed: 16697736]  [MGI Ref ID J:124915]

Viatour P; Ehmer U; Saddic LA; Dorrell C; Andersen JB; Lin C; Zmoos AF; Mazur PK; Schaffer BE; Ostermeier A; Vogel H; Sylvester KG; Thorgeirsson SS; Grompe M; Sage J. 2011. Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway. J Exp Med 208(10):1963-76. [PubMed: 21875955]  [MGI Ref ID J:177573]

Viret C; Leung-Theung-Long S; Serre L; Lamare C; Vignali DA; Malissen B; Carrier A; Guerder S. 2011. Thymus-specific serine protease controls autoreactive CD4 T cell development and autoimmune diabetes in mice. J Clin Invest 121(5):1810-21. [PubMed: 21505262]  [MGI Ref ID J:173941]

Viriyakosol S; Matthias MA; Swancutt MA; Kirkland TN; Vinetz JM. 2006. Toll-like receptor 4 protects against lethal Leptospira interrogans serovar icterohaemorrhagiae infection and contributes to in vivo control of leptospiral burden. Infect Immun 74(2):887-95. [PubMed: 16428731]  [MGI Ref ID J:105019]

Volkmann A; Doffinger R; Ruther U; Kyewski BA. 1996. Insertional mutagenesis affecting programmed cell death leads to thymic hyperplasia and altered thymopoiesis. J Immunol 156(1):136-45. [PubMed: 8598454]  [MGI Ref ID J:108193]

Vujanovic L; Szymkowski DE; Alber S; Watkins SC; Vujanovic NL; Butterfield LH. 2010. Virally infected and matured human dendritic cells activate natural killer cells via cooperative activity of plasma membrane-bound TNF and IL-15. Blood 116(4):575-83. [PubMed: 20430958]  [MGI Ref ID J:162797]

Waldner H; Sobel RA; Price N; Kuchroo VK. 2006. The autoimmune diabetes locus Idd9 regulates development of type 1 diabetes by affecting the homing of islet-specific T cells. J Immunol 176(9):5455-62. [PubMed: 16622013]  [MGI Ref ID J:131655]

Walzer PD; Runck J; Steele P; White M; Linke MJ; Sidman CL. 1997. Immunodeficient and immunosuppressed mice as models to test anti-Pneumocystis carinii drugs. Antimicrob Agents Chemother 41(2):251-8. [PubMed: 9021175]  [MGI Ref ID J:39028]

Wang C; Bogue MA; Levitt JM; Roth DB. 1999. Irradiation-mediated rescue of T cell-specific V(D)J recombination and thymocyte differentiation in severe combined immunodeficient mice by bone marrow cells. J Exp Med 190(9):1257-62. [PubMed: 10544197]  [MGI Ref ID J:115093]

Wang GY; So PL; Wang L; Libove E; Wang J; Epstein EH Jr. 2011. Establishment of murine basal cell carcinoma allografts: a potential model for preclinical drug testing and for molecular analysis. J Invest Dermatol 131(11):2298-305. [PubMed: 21833014]  [MGI Ref ID J:182174]

Wang J; Cho S; Ueno A; Cheng L; Xu BY; Desrosiers MD; Shi Y; Yang Y. 2008. Ligand-dependent induction of noninflammatory dendritic cells by anergic invariant NKT cells minimizes autoimmune inflammation. J Immunol 181(4):2438-45. [PubMed: 18684934]  [MGI Ref ID J:140188]

Wang LX; Kang G; Kumar P; Lu W; Li Y; Zhou Y; Li Q; Wood C. 2014. Humanized-BLT mouse model of Kaposi's sarcoma-associated herpesvirus infection. Proc Natl Acad Sci U S A 111(8):3146-51. [PubMed: 24516154]  [MGI Ref ID J:206819]

Wang P; Rodriguez RT; Wang J; Ghodasara A; Kim SK. 2011. Targeting SOX17 in human embryonic stem cells creates unique strategies for isolating and analyzing developing endoderm. Cell Stem Cell 8(3):335-46. [PubMed: 21362573]  [MGI Ref ID J:171124]

Wang Y; Sul HS. 2009. Pref-1 regulates mesenchymal cell commitment and differentiation through Sox9. Cell Metab 9(3):287-302. [PubMed: 19254573]  [MGI Ref ID J:147095]

Warner T; Balish E. 1995. Pulmonary alveolar proteinosis. A spontaneous and inducible disease in immunodeficient germ-free mice. Am J Pathol 146(4):1017-24. [PubMed: 7717446]  [MGI Ref ID J:24415]

Wecker H; Grusby MJ; Auchincloss H Jr. 1995. Effector cells must recognize antigens expressed in the graft to cause efficient skin graft rejection in SCID mice. Transplantation 59(8):1223-7. [PubMed: 7732570]  [MGI Ref ID J:25110]

Wei J; Wunderlich M; Fox C; Alvarez S; Cigudosa JC; Wilhelm JS; Zheng Y; Cancelas JA; Gu Y; Jansen M; Dimartino JF; Mulloy JC. 2008. Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia. Cancer Cell 13(6):483-95. [PubMed: 18538732]  [MGI Ref ID J:166360]

Westwell-Roper C; Dai DL; Soukhatcheva G; Potter KJ; van Rooijen N; Ehses JA; Verchere CB. 2011. IL-1 blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction. J Immunol 187(5):2755-65. [PubMed: 21813778]  [MGI Ref ID J:179268]

White RE; Ramer PC; Naresh KN; Meixlsperger S; Pinaud L; Rooney C; Savoldo B; Coutinho R; Bodor C; Gribben J; Ibrahim HA; Bower M; Nourse JP; Gandhi MK; Middeldorp J; Cader FZ; Murray P; Munz C; Allday MJ. 2012. EBNA3B-deficient EBV promotes B cell lymphomagenesis in humanized mice and is found in human tumors. J Clin Invest 122(4):1487-502. [PubMed: 22406538]  [MGI Ref ID J:184554]

Wicklein D; Schmidt A; Labitzky V; Ullrich S; Valent P; Schumacher U. 2013. E- and p-selectins are essential for repopulation of chronic myelogenous and chronic eosinophilic leukemias in a scid mouse xenograft model. PLoS One 8(7):e70139. [PubMed: 23922938]  [MGI Ref ID J:204363]

Wigginton JM; Lee JK; Wiltrout TA; Alvord WG; Hixon JA; Subleski J; Back TC; Wiltrout RH. 2002. Synergistic engagement of an ineffective endogenous anti-tumor immune response and induction of IFN-gamma and Fas-ligand-dependent tumor eradication by combined administration of IL-18 and IL-2. J Immunol 169(8):4467-74. [PubMed: 12370382]  [MGI Ref ID J:109850]

Wilkison M; Gauss K; Ran Y; Searles S; Taylor D; Meissner N. 2012. Type 1 interferons suppress accelerated osteoclastogenesis and prevent loss of bone mass during systemic inflammatory responses to pneumocystis lung infection. Am J Pathol 181(1):151-62. [PubMed: 22626807]  [MGI Ref ID J:185537]

Willimann K; Matile H; Weiss NA; Imhof BA. 1995. In vivo sequestration of Plasmodium falciparum-infected human erythrocytes: a severe combined immunodeficiency mouse model for cerebral malaria. J Exp Med 182(3):643-53. [PubMed: 7650476]  [MGI Ref ID J:28277]

Winslow GM; Yager E; Shilo K; Collins DN; Chu FK. 1998. Infection of the laboratory mouse with the intracellular pathogen Ehrlichia chaffeensis. Infect Immun 66(8):3892-9. [PubMed: 9673277]  [MGI Ref ID J:48876]

Wong FS; Du W; Thomas IJ; Wen L. 2005. The influence of the major histocompatibility complex on development of autoimmune diabetes in RIP-B7.1 mice. Diabetes 54(7):2032-40. [PubMed: 15983204]  [MGI Ref ID J:109830]

Woods NB; Bottero V; Schmidt M; von Kalle C; Verma IM. 2006. Gene therapy: therapeutic gene causing lymphoma. Nature 440(7088):1123. [PubMed: 16641981]  [MGI Ref ID J:108380]

Wu T; Sun C; Chen Z; Zhen Y; Peng J; Qi Z; Yang X; Zhao Y. 2012. Smad3-deficient CD11b(+)Gr1(+) myeloid-derived suppressor cells prevent allograft rejection via the nitric oxide pathway. J Immunol 189(10):4989-5000. [PubMed: 23045614]  [MGI Ref ID J:190588]

Wu X; Zhang W; Font-Burgada J; Palmer T; Hamil AS; Biswas SK; Poidinger M; Borcherding N; Xie Q; Ellies LG; Lytle NK; Wu LW; Fox RG; Yang J; Dowdy SF; Reya T; Karin M. 2014. Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade. Proc Natl Acad Sci U S A 111(38):13870-5. [PubMed: 25189770]  [MGI Ref ID J:216379]

Wunderlich M; Chou FS; Link KA; Mizukawa B; Perry RL; Carroll M; Mulloy JC. 2010. AML xenograft efficiency is significantly improved in NOD/SCID-IL2RG mice constitutively expressing human SCF, GM-CSF and IL-3. Leukemia 24(10):1785-8. [PubMed: 20686503]  [MGI Ref ID J:166359]

Xu W; Xin L; Soong L; Zhang K. 2011. Sphingolipid degradation by Leishmania major is required for its resistance to acidic pH in the mammalian host. Infect Immun 79(8):3377-87. [PubMed: 21576322]  [MGI Ref ID J:175272]

XuFeng R; Boyer MJ; Shen H; Li Y; Yu H; Gao Y; Yang Q; Wang Q; Cheng T. 2009. ADAR1 is required for hematopoietic progenitor cell survival via RNA editing. Proc Natl Acad Sci U S A 106(42):17763-8. [PubMed: 19805087]  [MGI Ref ID J:153698]

Yahata T; Ando K; Nakamura Y; Ueyama Y; Shimamura K; Tamaoki N; Kato S; Hotta T. 2002. Functional human T lymphocyte development from cord blood CD34+ cells in nonobese diabetic/Shi-scid, IL-2 receptor gamma null mice. J Immunol 169(1):204-9. [PubMed: 12077246]  [MGI Ref ID J:77239]

Yamasaki H; Sada A; Iwata T; Niwa T; Tomizawa M; Xanthopoulos KG; Koike T; Shiojiri N. 2006. Suppression of C/EBP{alpha} expression in periportal hepatoblasts may stimulate biliary cell differentiation through increased Hnf6 and Hnf1b expression. Development 133(21):4233-43. [PubMed: 17021047]  [MGI Ref ID J:114400]

Yamashita J; Iwamura C; Ito T; Narita M; Hara Y; Sasaki T; Masuda D; Takahashi M; Tsuchiya M; Hada K; Ishikawa M; Matsuo T; Ohno Y; Tanaka H; Maruyama H; Ogawa Y; Nakayama T. 2013. Paraoxonase-1 suppresses experimental colitis via the inhibition of IFN-gamma production from CD4 T cells. J Immunol 191(2):949-60. [PubMed: 23772025]  [MGI Ref ID J:204816]

Yan BS; Pichugin AV; Jobe O; Helming L; Eruslanov EB; Gutierrez-Pabello JA; Rojas M; Shebzukhov YV; Kobzik L; Kramnik I. 2007. Progression of pulmonary tuberculosis and efficiency of bacillus Calmette-Guerin vaccination are genetically controlled via a common sst1-mediated mechanism of innate immunity. J Immunol 179(10):6919-32. [PubMed: 17982083]  [MGI Ref ID J:154010]

Yang GX; Wu Y; Tsukamoto H; Leung PS; Lian ZX; Rainbow DB; Hunter KM; Morris GA; Lyons PA; Peterson LB; Wicker LS; Gershwin ME; Ridgway WM. 2011. CD8 T cells mediate direct biliary ductule damage in nonobese diabetic autoimmune biliary disease. J Immunol 186(2):1259-67. [PubMed: 21169553]  [MGI Ref ID J:168755]

Yang L; Chen G; Mohanty S; Scott G; Fazal F; Rahman A; Begum S; Hynes RO; Xu L. 2011. GPR56 Regulates VEGF Production and Angiogenesis during Melanoma Progression. Cancer Res 71(16):5558-68. [PubMed: 21724588]  [MGI Ref ID J:175446]

Yang L; Friedland S; Corson N; Xu L. 2014. GPR56 inhibits melanoma growth by internalizing and degrading its ligand TG2. Cancer Res 74(4):1022-31. [PubMed: 24356421]  [MGI Ref ID J:208172]

Yang PL; Althage A; Chung J; Maier H; Wieland S; Isogawa M; Chisari FV. 2010. Immune effectors required for hepatitis B virus clearance. Proc Natl Acad Sci U S A 107(2):798-802. [PubMed: 20080755]  [MGI Ref ID J:156523]

Yang X; Zhang Y; Yang Y; Lim S; Cao Z; Rak J; Cao Y. 2013. Vascular endothelial growth factor-dependent spatiotemporal dual roles of placental growth factor in modulation of angiogenesis and tumor growth. Proc Natl Acad Sci U S A 110(34):13932-7. [PubMed: 23918367]  [MGI Ref ID J:200676]

Yang YG; Chen AM; Garrett LJ; Sergio JJ; Theodore P; Awwad M; VerHalen J; Bodine DM; Sachs DH; Sykes M. 2000. Development and analysis of transgenic mice expressing porcine hematopoietic cytokines: a model for achieving durable porcine hematopoietic chimerism across an extensive xenogeneic barrier. Xenotransplantation 7(1):58-64. [PubMed: 10809058]  [MGI Ref ID J:94302]

Yasuda A; Tsuji O; Shibata S; Nori S; Takano M; Kobayashi Y; Takahashi Y; Fujiyoshi K; Hara CM; Miyawaki A; Okano HJ; Toyama Y; Nakamura M; Okano H. 2011. Significance of remyelination by neural stem/progenitor cells transplanted into the injured spinal cord. Stem Cells 29(12):1983-94. [PubMed: 22028197]  [MGI Ref ID J:190194]

Yasutomo K; Maeda K; Hisaeda H; Good RA; Kuroda Y; Himeno K. 1997. The Fas-deficient SCID mouse exhibits the development of T cells in the thymus. J Immunol 158(10):4729-33. [PubMed: 9144486]  [MGI Ref ID J:40207]

Yeh ES; Lew BO; Means AR. 2006. The loss of PIN1 deregulates cyclin E and sensitizes mouse embryo fibroblasts to genomic instability. J Biol Chem 281(1):241-51. [PubMed: 16223725]  [MGI Ref ID J:105781]

Yi S; Ji M; Wu J; Ma X; Phillips P; Hawthorne WJ; O'Connell PJ. 2012. Adoptive transfer with in vitro expanded human regulatory T cells protects against porcine islet xenograft rejection via interleukin-10 in humanized mice. Diabetes 61(5):1180-91. [PubMed: 22403295]  [MGI Ref ID J:196728]

Yi Z; Diz R; Martin AJ; Morillon YM; Kline DE; Li L; Wang B; Tisch R. 2012. Long-term remission of diabetes in NOD mice is induced by nondepleting anti-CD4 and anti-CD8 antibodies. Diabetes 61(11):2871-80. [PubMed: 22751694]  [MGI Ref ID J:208520]

Yi Z; Li L; Garland A; He Q; Wang H; Katz JD; Tisch R; Wang B. 2012. IFN-gamma receptor deficiency prevents diabetes induction by diabetogenic CD4+, but not CD8+, T cells. Eur J Immunol 42(8):2010-8. [PubMed: 22865049]  [MGI Ref ID J:187880]

Yoshida K; van den Berg TK; Dijkstra CD. 1994. The functional state of follicular dendritic cells in severe combined immunodeficient (SCID) mice: role of the lymphocytes. Eur J Immunol 24(2):464-8. [PubMed: 8299696]  [MGI Ref ID J:16866]

Yoshioka T; Otero J; Chen Y; Kim YM; Koutcher JA; Satagopan J; Reuter V; Carver B; de Stanchina E; Enomoto K; Greenberg NM; Scardino PT; Scher HI; Sawyers CL; Giancotti FG. 2013. beta4 Integrin signaling induces expansion of prostate tumor progenitors. J Clin Invest :. [PubMed: 23348745]  [MGI Ref ID J:194482]

Yoshizawa M; Okada T; Morikawa Y; Sasaki F; Kiso Y. 1994. Murine granulated metrial gland cell population in beige (bg/bg) and SCID (scid/scid) genotypes. J Vet Med Sci 56(2):415-6. [PubMed: 8075241]  [MGI Ref ID J:21177]

Young D; Kearney JF. 1995. Sequence analysis and antigen binding characteristics of Ig SCID Ig+ mice. Int Immunol 7(5):807-19. [PubMed: 7547707]  [MGI Ref ID J:25547]

Yui MA; Rothenberg EV. 2004. Deranged early T cell development in immunodeficient strains of nonobese diabetic mice. J Immunol 173(9):5381-91. [PubMed: 15494484]  [MGI Ref ID J:132809]

Zane NA; Gundelach JH; Lindquist LD; Bram RJ. 2012. Essential role for CAML in follicular B cell survival and homeostasis. J Immunol 188(7):3009-18. [PubMed: 22351938]  [MGI Ref ID J:183110]

Zare F; Bokarewa M; Nenonen N; Bergstrom T; Alexopoulou L; Flavell RA; Tarkowski A. 2004. Arthritogenic properties of double-stranded (viral) RNA. J Immunol 172(9):5656-63. [PubMed: 15100310]  [MGI Ref ID J:89689]

Zavidij O; Ball CR; Herbst F; Fessler S; Schmidt M; von Kalle C; Glimm H. 2010. Hematopoietic activity of human short-term repopulating cells in mobilized peripheral blood cell transplants is restricted to the first 5 months after transplantation. Blood 115(24):5023-5. [PubMed: 20382848]  [MGI Ref ID J:161539]

Zhang B; Strauss AC; Chu S; Li M; Ho Y; Shiang KD; Snyder DS; Huettner CS; Shultz L; Holyoake T; Bhatia R. 2010. Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate. Cancer Cell 17(5):427-42. [PubMed: 20478526]  [MGI Ref ID J:160523]

Zhang C; Cui Y; Houston S; Chang LJ. 1996. Protective immunity to HIV-1 in SCID/beige mice reconstituted with peripheral blood lymphocytes of exposed but uninfected individuals. Proc Natl Acad Sci U S A 93(25):14720-5. [PubMed: 8962121]  [MGI Ref ID J:37253]

Zhang H; Hilton MJ; Anolik JH; Welle SL; Zhao C; Yao Z; Li X; Wang Z; Boyce BF; Xing L. 2014. NOTCH inhibits osteoblast formation in inflammatory arthritis via noncanonical NF-kappaB. J Clin Invest 124(7):3200-14. [PubMed: 24892805]  [MGI Ref ID J:213803]

Zhang H; Zhou X; McQuade T; Li J; Chan FK; Zhang J. 2011. Functional complementation between FADD and RIP1 in embryos and lymphocytes. Nature 471(7338):373-6. [PubMed: 21368761]  [MGI Ref ID J:170816]

Zhang JQ; Okumura C; McCarty T; Shin MS; Mukhopadhyay P; Hori M; Torrey TA; Naghashfar Z; Zhou JX; Lee CH; Roopenian DC; Morse HC 3rd; Davidson WF. 2004. Evidence for selective transformation of autoreactive immature plasma cells in mice deficient in Fasl. J Exp Med 200(11):1467-78. [PubMed: 15583018]  [MGI Ref ID J:94696]

Zhang S; Yajima H; Huynh H; Zheng J; Callen E; Chen HT; Wong N; Bunting S; Lin YF; Li M; Lee KJ; Story M; Gapud E; Sleckman BP; Nussenzweig A; Zhang CC; Chen DJ; Chen BP. 2011. Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair. J Cell Biol 193(2):295-305. [PubMed: 21482716]  [MGI Ref ID J:171351]

Zhang X; Wan G; Mlotshwa S; Vance V; Berger FG; Chen H; Lu X. 2010. Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway. Cancer Res 70(18):7176-86. [PubMed: 20668064]  [MGI Ref ID J:164245]

Zhao Y; Guo C; Hwang D; Lin B; Dingeldein M; Mihailescu D; Sam S; Sidhwani S; Zhang Y; Jain S; Skidgel RA; Prabhakar BS; Mazzone T; Holterman MJ. 2010. Selective destruction of mouse islet beta cells by human T lymphocytes in a newly-established humanized type 1 diabetic model. Biochem Biophys Res Commun 399(4):629-36. [PubMed: 20691153]  [MGI Ref ID J:164900]

Zheng CF; Guan KL. 1993. Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2. J Biol Chem 268(15):11435-9. [PubMed: 8388392]  [MGI Ref ID J:31929]

Zheng M; Ramsay AJ; Robichaux MB; Norris KA; Kliment C; Crowe C; Rapaka RR; Steele C; McAllister F; Shellito JE; Marrero L; Schwarzenberger P; Zhong Q; Kolls JK. 2005. CD4+ T cell-independent DNA vaccination against opportunistic infections. J Clin Invest 115(12):3536-44. [PubMed: 16308571]  [MGI Ref ID J:104584]

Zhou P; Szot GL; Guo Z; Kim O; He G; Wang J; Grusby MJ; Newell KA; Thistlethwaite JR; Bluestone JA; Alegre ML. 2000. Role of STAT4 and STAT6 signaling in allograft rejection and CTLA4-Ig-mediated tolerance. J Immunol 165(10):5580-7. [PubMed: 11067913]  [MGI Ref ID J:119580]

Zhu C; Roth DB. 1995. Characterization of coding ends in thymocytes of scid mice: implications for the mechanism of V(D)J recombination. Immunity 2(1):101-12. [PubMed: 7600297]  [MGI Ref ID J:28349]

de Laval B; Pawlikowska P; Petit-Cocault L; Bilhou-Nabera C; Aubin-Houzelstein G; Souyri M; Pouzoulet F; Gaudry M; Porteu F. 2013. Thrombopoietin-increased DNA-PK-dependent DNA repair limits hematopoietic stem and progenitor cell mutagenesis in response to DNA damage. Cell Stem Cell 12(1):37-48. [PubMed: 23246483]  [MGI Ref ID J:194947]

de Oliveira VL; Keijsers RR; van de Kerkhof PC; Seyger MM; Fasse E; Svensson L; Latta M; Norsgaard H; Labuda T; Hupkens P; van Erp PE; Joosten I; Koenen HJ. 2012. Humanized mouse model of skin inflammation is characterized by disturbed keratinocyte differentiation and influx of IL-17A producing T cells. PLoS One 7(10):e45509. [PubMed: 23094018]  [MGI Ref ID J:192181]

van Buul PP; Abramsson-Zetterberg L; Zandman IM; van Duyn-Goedhart A. 1998. Further characterization of the radiosensitivity of the scid mouse. Int J Radiat Biol 74(1):35-41. [PubMed: 9687973]  [MGI Ref ID J:115137]

van Essen D; Dullforce P; Gray D. 2000. Role of B cells in maintaining helper T-cell memory. Philos Trans R Soc Lond B Biol Sci 355(1395):351-5. [PubMed: 10794053]  [MGI Ref ID J:106317]

van Rossum AM; Lysenko ES; Weiser JN. 2005. Host and bacterial factors contributing to the clearance of colonization by Streptococcus pneumoniae in a murine model. Infect Immun 73(11):7718-26. [PubMed: 16239576]  [MGI Ref ID J:104292]

van den Pol AN. 2009. Brain trauma enhances transient cytomegalovirus invasion of the brain only in mice that are immunodeficient. J Virol 83(1):420-7. [PubMed: 18945784]  [MGI Ref ID J:153392]

van der Touw W; Cravedi P; Kwan WH; Paz-Artal E; Merad M; Heeger PS. 2013. Cutting edge: Receptors for C3a and C5a modulate stability of alloantigen-reactive induced regulatory T cells. J Immunol 190(12):5921-5. [PubMed: 23690475]  [MGI Ref ID J:204834]

von Herrath MG; Dockter J; Oldstone MB. 1994. How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model. Immunity 1(3):231-42. [PubMed: 7889411]  [MGI Ref ID J:81287]

Tg(CSF2)2Ygy related

Abe M; Cheng J; Qi J; Glaser RM; Thall AD; Sykes M; Yang YG. 2002. Elimination of porcine hemopoietic cells by macrophages in mice. J Immunol 168(2):621-8. [PubMed: 11777954]  [MGI Ref ID J:106416]

Abe M; Qi J; Sykes M; Yang YG. 2002. Mixed chimerism induces donor-specific T-cell tolerance across a highly disparate xenogeneic barrier. Blood 99(10):3823-9. [PubMed: 11986242]  [MGI Ref ID J:106417]

Eguchi H; Knosalla C; Lan P; Cheng J; Diouf B; Wang L; Abe M; Schuurman HJ; Sachs DH; Sykes M; Cooper DK; Yang YG. 2004. T cells from presensitized donors fail to cause graft-versus-host disease in a pig-to-mouse xenotransplantation model. Transplantation 78(11):1609-17. [PubMed: 15591949]  [MGI Ref ID J:107052]

Yang YG; Chen AM; Garrett LJ; Sergio JJ; Theodore P; Awwad M; VerHalen J; Bodine DM; Sachs DH; Sykes M. 2000. Development and analysis of transgenic mice expressing porcine hematopoietic cytokines: a model for achieving durable porcine hematopoietic chimerism across an extensive xenogeneic barrier. Xenotransplantation 7(1):58-64. [PubMed: 10809058]  [MGI Ref ID J:94302]

Tg(IL3)1Ygy related

Abe M; Cheng J; Qi J; Glaser RM; Thall AD; Sykes M; Yang YG. 2002. Elimination of porcine hemopoietic cells by macrophages in mice. J Immunol 168(2):621-8. [PubMed: 11777954]  [MGI Ref ID J:106416]

Abe M; Qi J; Sykes M; Yang YG. 2002. Mixed chimerism induces donor-specific T-cell tolerance across a highly disparate xenogeneic barrier. Blood 99(10):3823-9. [PubMed: 11986242]  [MGI Ref ID J:106417]

Yang YG; Chen AM; Garrett LJ; Sergio JJ; Theodore P; Awwad M; VerHalen J; Bodine DM; Sachs DH; Sykes M. 2000. Development and analysis of transgenic mice expressing porcine hematopoietic cytokines: a model for achieving durable porcine hematopoietic chimerism across an extensive xenogeneic barrier. Xenotransplantation 7(1):58-64. [PubMed: 10809058]  [MGI Ref ID J:94302]

Tg(KITLG)3Ygy related

Abe M; Cheng J; Qi J; Glaser RM; Thall AD; Sykes M; Yang YG. 2002. Elimination of porcine hemopoietic cells by macrophages in mice. J Immunol 168(2):621-8. [PubMed: 11777954]  [MGI Ref ID J:106416]

Abe M; Qi J; Sykes M; Yang YG. 2002. Mixed chimerism induces donor-specific T-cell tolerance across a highly disparate xenogeneic barrier. Blood 99(10):3823-9. [PubMed: 11986242]  [MGI Ref ID J:106417]

Eguchi H; Knosalla C; Lan P; Cheng J; Diouf B; Wang L; Abe M; Schuurman HJ; Sachs DH; Sykes M; Cooper DK; Yang YG. 2004. T cells from presensitized donors fail to cause graft-versus-host disease in a pig-to-mouse xenotransplantation model. Transplantation 78(11):1609-17. [PubMed: 15591949]  [MGI Ref ID J:107052]

Yang YG; Chen AM; Garrett LJ; Sergio JJ; Theodore P; Awwad M; VerHalen J; Bodine DM; Sachs DH; Sykes M. 2000. Development and analysis of transgenic mice expressing porcine hematopoietic cytokines: a model for achieving durable porcine hematopoietic chimerism across an extensive xenogeneic barrier. Xenotransplantation 7(1):58-64. [PubMed: 10809058]  [MGI Ref ID J:94302]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

Pricing for USA, Canada and Mexico shipping destinations View International Pricing


Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2625.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $1725.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing


Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3412.50
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $2242.50

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

General Supply Notes

Control Information

   001303 NOD.CB17-Prkdcscid/J
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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Terms of Use

Terms of Use

General Terms and Conditions

For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty


In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.