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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Former Names NOD.129S2-Stat6tm1Gru/JbsJ (Changed: 15-DEC-04 ) Type Congenic; Mutant Strain; Targeted Mutation; Additional information on Genetically Engineered Mutant Mice. Species laboratory mouse Background Strain NOD/ShiLtJ Donor Strain 129S2 (D3 ES cell derived) H2 Haplotype g7 Donating Investigator Jeffrey Bluestone, University of California, San Francisco Appearance
pink-eyed albino
Related Genotype: A/A Tyrc/TyrcDescription
NOD mice homozygous for the Stat6tm1Gru mutation exhibit an increased diabetes incidence compared to NOD controls and show a striking defect in the generation of Th2 cells. Lymphocytes are unable to respond to IL4 as measured in a variety of in vitro and in vivo assays. This strain can be used to look at the role of Il4 in diabetes development.
Control Information
| Control | ||
|---|---|---|
| 001976 NOD/ShiLtJ | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Stat6tm1Gru allele
005977 B6.129S2(C)-Stat6tm1Gru/J 003750 C.129S2-Stat4tm1Gru Stat6tm1Gru/J 002828 C.129S2-Stat6tm1Gru/J View Strains carrying Stat6tm1Gru (3 strains)
Additional Web Information
Congenic Nomenclature
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
Stat6tm1Gru relatedCancer Research
Growth Factors/Receptors/Cytokines
Diabetes and Obesity Research
Type 1 Diabetes (IDDM)
Type 1 Diabetes (IDDM) Analysis Strains (NOD Congenics with Mutations Affecting Cytokine Production by Autoreactive T Cells)
Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Growth Factors/Receptors/Cytokines
Immunology and Inflammation Research
Immunodeficiency
Intracellular Signaling Molecules
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Stat6tm1Gru | ||
|---|---|---|---|
| Allele Name | targeted mutation 1, Michael J Grusby | ||
| Allele Type | Targeted (knock-out) | ||
| Common Name(s) | Stat6-; | ||
| Mutation Made By | Michael Grusby, Harvard Medical School | ||
| Strain of Origin | 129S2/SvPas | ||
| ES Cell Line Name | D3 | ||
| ES Cell Line Strain | 129S2/SvPas | ||
| Gene Symbol and Name | Stat6, signal transducer and activator of transcription 6 | ||
| Chromosome | 10 | ||
| Gene Common Name(s) | D12S1644; IL-4-STAT; STAT6B; STAT6C; | ||
| Molecular Note | The region encoding the SH2 domain, which is essential for dimerization, was replaced by the insertion of a neomycin selection cassette. Immunoblot analysis of lysates from the spleens and thymi of homozygous mutant mice showed an absence of encoded protein. [MGI Ref ID J:31932] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Stat6tm1Gru, STD PCR, vers. 2
Helpful Links
Optimizing PCR Protocols
References
References
Selected Reference(s)
Kaplan MH; Schindler U; Smiley ST; Grusby MJ. 1996. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity 4(3):313-9. [PubMed: 8624821] [MGI Ref ID J:31932]
Additional References
Stat6tm1Gru relatedAgarwal S; Rao A. 1998. Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation. Immunity 9(6):765-75. [PubMed: 9881967] [MGI Ref ID J:51833]
Amsen D; Antov A; Jankovic D; Sher A; Radtke F; Souabni A; Busslinger M; McCright B; Gridley T; Flavell RA. 2007. Direct regulation of gata3 expression determines the T helper differentiation potential of notch. Immunity 27(1):89-99. [PubMed: 17658279] [MGI Ref ID J:123631]
Armstrong BD; Abad C; Chhith S; Cheung-Lau G; Hajji OE; Coute AC; Ngo DH; Waschek JA. 2006. Impairment of axotomy-induced pituitary adenylyl cyclase-activating peptide gene expression in T helper 2 lymphocyte-deficient mice. Neuroreport 17(3):309-12. [PubMed: 16462603] [MGI Ref ID J:106085]
Bian K; Zhong M; Harari Y; Lai M; Weisbrodt N; Murad F. 2005. Helminth regulation of host IL-4Ralpha/Stat6 signaling: mechanism underlying NOS-2 inhibition by Trichinella spiralis. Proc Natl Acad Sci U S A 102(11):3936-41. [PubMed: 15741272] [MGI Ref ID J:97167]
Blease K; Schuh JM; Jakubzick C; Lukacs NW; Kunkel SL; Joshi BH; Puri RK; Kaplan MH; Hogaboam CM. 2002. Stat6-deficient mice develop airway hyperresponsiveness and peribronchial fibrosis during chronic fungal asthma. Am J Pathol 160(2):481-90. [PubMed: 11839568] [MGI Ref ID J:74497]
Bour-Jordan H; Grogan JL; Tang Q; Auger JA; Locksley RM; Bluestone JA. 2003. CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment. Nat Immunol 4(2):182-8. [PubMed: 12524538] [MGI Ref ID J:126980]
Broxmeyer HE; Bruns HA; Zhang S; Cooper S; Hangoc G; McKenzie AN; Dent AL; Schindler U; Naeger LK; Hoey T; Kaplan MH. 2002. Th1 cells regulate hematopoietic progenitor cell homeostasis by production of oncostatin m. Immunity 16(6):815-25. [PubMed: 12121663] [MGI Ref ID J:77523]
Bunting KD; Yu WM; Bradley HL; Haviernikova E; Kelly-Welch AE; Keegan AD; Qu CK. 2004. Increased numbers of committed myeloid progenitors but not primitive hematopoietic stem/progenitors in mice lacking STAT6 expression. J Leukoc Biol 76(2):484-90. [PubMed: 15123777] [MGI Ref ID J:91477]
Burgis S; Gessner A. 2007. Unexpected phenotype of STAT6 heterozygous mice implies distinct STAT6 dosage requirements for different IL-4 functions. Int Arch Allergy Immunol 143(4):263-8. [PubMed: 17347574] [MGI Ref ID J:140305]
Castilow EM; Legge KL; Varga SM. 2008. Cutting edge: Eosinophils do not contribute to respiratory syncytial virus vaccine-enhanced disease. J Immunol 181(10):6692-6. [PubMed: 18981084] [MGI Ref ID J:140954]
Chang HC; Zhang S; Kaplan MH. 2002. Neonatal tolerance in the absence of Stat4- and Stat6- dependent Th cell differentiation. J Immunol 169(8):4124-8. [PubMed: 12370340] [MGI Ref ID J:120160]
Chang S; Aune TM. 2007. Dynamic changes in histone-methylation 'marks' across the locus encoding interferon-gamma during the differentiation of T helper type 2 cells. Nat Immunol 8(7):723-31. [PubMed: 17546034] [MGI Ref ID J:123355]
Chen CC; Louie S; McCormick B; Walker WA; Shi HN. 2005. Concurrent infection with an intestinal helminth parasite impairs host resistance to enteric Citrobacter rodentium and enhances Citrobacter-induced colitis in mice. Infect Immun 73(9):5468-81. [PubMed: 16113263] [MGI Ref ID J:100416]
Chen Z; Lund R; Aittokallio T; Kosonen M; Nevalainen O; Lahesmaa R. 2003. Identification of novel IL-4/Stat6-regulated genes in T lymphocytes. J Immunol 171(7):3627-35. [PubMed: 14500660] [MGI Ref ID J:107367]
Chesler DA; Reiss CS. 2002. IL-12, while beneficial, is not essential for the host response to VSV encephalitis. J Neuroimmunol 131(1-2):92-7. [PubMed: 12458040] [MGI Ref ID J:102956]
Chitnis T; Najafian N; Benou C; Salama AD; Grusby MJ; Sayegh MH; Khoury SJ. 2001. Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis. J Clin Invest 108(5):739-47. [PubMed: 11544280] [MGI Ref ID J:71460]
Chitnis T; Salama AD; Grusby MJ; Sayegh MH; Khoury SJ. 2004. Defining Th1 and Th2 immune responses in a reciprocal cytokine environment in vivo. J Immunol 172(7):4260-5. [PubMed: 15034039] [MGI Ref ID J:88725]
Chung DR; Kasper DL; Panzo RJ; Chtinis T; Grusby MJ; Sayegh MH; Tzianabos AO. 2003. CD4+ T cells mediate abscess formation in intra-abdominal sepsis by an IL-17-dependent mechanism. J Immunol 170(4):1958-63. [PubMed: 12574364] [MGI Ref ID J:81809]
Devoss JJ; Shum AK; Johannes KP; Lu W; Krawisz AK; Wang P; Yang T; Leclair NP; Austin C; Strauss EC; Anderson MS. 2008. Effector mechanisms of the autoimmune syndrome in the murine model of autoimmune polyglandular syndrome type 1. J Immunol 181(6):4072-9. [PubMed: 18768863] [MGI Ref ID J:139094]
Fang TC; Yashiro-Ohtani Y; Del Bianco C; Knoblock DM; Blacklow SC; Pear WS. 2007. Notch directly regulates Gata3 expression during T helper 2 cell differentiation. Immunity 27(1):100-10. [PubMed: 17658278] [MGI Ref ID J:123632]
Finkelman FD; Morris SC; Orekhova T; Mori M; Donaldson D; Reiner SL; Reilly NL; Schopf L; Urban JF Jr. 2000. Stat6 regulation of in vivo IL-4 responses. J Immunol 164(5):2303-10. [PubMed: 10679064] [MGI Ref ID J:112038]
Finnegan A; Grusby MJ; Kaplan CD; O'Neill SK; Eibel H; Koreny T; Czipri M; Mikecz K; Zhang J. 2002. IL-4 and IL-12 regulate proteoglycan-induced arthritis through Stat-dependent mechanisms. J Immunol 169(6):3345-52. [PubMed: 12218156] [MGI Ref ID J:120443]
Fraidakis MJ; Kiyotani T; Pernold K; Bergstrom J; Olson L. 2007. Recovery from spinal cord injury in tumor necrosis factor-alpha, signal transducers and activators of transcription 4 and signal transducers and activators of transcription 6 null mice. Neuroreport 18(2):185-9. [PubMed: 17301687] [MGI Ref ID J:120345]
Ghiasi H; Osorio Y; Nesburn AB; Wechsler SL. 2002. Enhanced clearance of herpes simplex virus type 1 and reduced herpetic eye disease in STAT6 knockout mice is associated with increased IL-2. Virology 302(2):286-93. [PubMed: 12441072] [MGI Ref ID J:107370]
Haczku A; Cao Y; Vass G; Kierstein S; Nath P; Atochina-Vasserman EN; Scanlon ST; Li L; Griswold DE; Chung KF; Poulain FR; Hawgood S; Beers MF; Crouch EC. 2006. IL-4 and IL-13 form a negative feedback circuit with surfactant protein-D in the allergic airway response. J Immunol 176(6):3557-65. [PubMed: 16517724] [MGI Ref ID J:129507]
Hadeiba H; Locksley RM. 2003. Lung CD25 CD4 regulatory T cells suppress type 2 immune responses but not bronchial hyperreactivity. J Immunol 170(11):5502-10. [PubMed: 12759427] [MGI Ref ID J:109990]
Harrington LE; Hatton RD; Mangan PR; Turner H; Murphy TL; Murphy KM; Weaver CT. 2005. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 6(11):1123-32. [PubMed: 16200070] [MGI Ref ID J:112601]
Harris MB; Chang CC; Berton MT; Danial NN; Zhang J; Kuehner D; Ye BH; Kvatyuk M; Pandolfi PP; Cattoretti G; Dalla-Favera R; Rothman PB. 1999. Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: specific regulation of iepsilon transcription and immunoglobulin E switching. Mol Cell Biol 19(10):7264-75. [PubMed: 10490661] [MGI Ref ID J:57856]
Herold KC; Lu J; Rulifson I; Vezys V; Taub D; Grusby MJ; Bluestone JA. 1997. Regulation of C-C chemokine production by murine T cells by CD28/B7 costimulation. J Immunol 159(9):4150-3. [PubMed: 9379007] [MGI Ref ID J:110673]
Holz A; Bot A; Coon B; Wolfe T; Grusby MJ; von Herrath MG. 1999. Disruption of the STAT4 signaling pathway protects from autoimmune diabetes while retaining antiviral immune competence. J Immunol 163(10):5374-82. [PubMed: 10553062] [MGI Ref ID J:107047]
Hoshino A; Tsuji T; Matsuzaki J; Jinushi T; Ashino S; Teramura T; Chamoto K; Tanaka Y; Asakura Y; Sakurai T; Mita Y; Takaoka A; Nakaike S; Takeshima T; Ikeda H; Nishimura T. 2004. STAT6-mediated signaling in Th2-dependent allergic asthma: critical role for the development of eosinophilia, airway hyper-responsiveness and mucus hypersecretion, distinct from its role in Th2 differentiation. Int Immunol 16(10):1497-505. [PubMed: 15351784] [MGI Ref ID J:93632]
Howell MD; Gallo RL; Boguniewicz M; Jones JF; Wong C; Streib JE; Leung DY. 2006. Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus. Immunity 24(3):341-8. [PubMed: 16546102] [MGI Ref ID J:113325]
Huber SA; Sakkinen P; David C; Newell MK; Tracy RP. 2001. T helper-cell phenotype regulates atherosclerosis in mice under conditions of mild hypercholesterolemia. Circulation 103(21):2610-6. [PubMed: 11382732] [MGI Ref ID J:133189]
Ingram JL; Antao-Menezes A; Mangum JB; Lyght O; Lee PJ; Elias JA; Bonner JC. 2006. Opposing actions of Stat1 and Stat6 on IL-13-induced up-regulation of early growth response-1 and platelet-derived growth factor ligands in pulmonary fibroblasts. J Immunol 177(6):4141-8. [PubMed: 16951379] [MGI Ref ID J:138041]
Iribarren P; Chen K; Hu J; Zhang X; Gong W; Wang JM. 2005. IL-4 inhibits the expression of mouse formyl peptide receptor 2, a receptor for amyloid beta1-42, in TNF-alpha-activated microglia. J Immunol 175(9):6100-6. [PubMed: 16237106] [MGI Ref ID J:119383]
Ishikawa Y; Yoshimoto T; Nakanishi K. 2006. Contribution of IL-18-induced innate T cell activation to airway inflammation with mucus hypersecretion and airway hyperresponsiveness. Int Immunol 18(6):847-55. [PubMed: 16611648] [MGI Ref ID J:109098]
Jacob CO; Zang S; Li L; Ciobanu V; Quismorio F; Mizutani A; Satoh M; Koss M. 2003. Pivotal role of Stat4 and Stat6 in the pathogenesis of the lupus-like disease in the New Zealand mixed 2328 mice. J Immunol 171(3):1564-71. [PubMed: 12874250] [MGI Ref ID J:120665]
Jaruga B; Hong F; Sun R; Radaeva S; Gao B. 2003. Crucial role of IL-4/STAT6 in T cell-mediated hepatitis: up-regulating eotaxins and IL-5 and recruiting leukocytes. J Immunol 171(6):3233-44. [PubMed: 12960353] [MGI Ref ID J:85386]
Jensen SM; Meijer SL; Kurt RA; Urba WJ; Hu HM; Fox BA. 2003. Regression of a mammary adenocarcinoma in STAT6-/- mice is dependent on the presence of STAT6-reactive T cells. J Immunol 170(4):2014-21. [PubMed: 12574371] [MGI Ref ID J:107369]
Jessup HK; Brewer AW; Omori M; Rickel EA; Budelsky AL; Yoon BR; Ziegler SF; Comeau MR. 2008. Intradermal administration of thymic stromal lymphopoietin induces a T cell- and eosinophil-dependent systemic Th2 inflammatory response. J Immunol 181(6):4311-9. [PubMed: 18768889] [MGI Ref ID J:139079]
Junttila IS; Mizukami K; Dickensheets H; Meier-Schellersheim M; Yamane H; Donnelly RP; Paul WE. 2008. Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4Ralpha, IL-13Ralpha1, and gammac regulates relative cytokine sensitivity. J Exp Med 205(11):2595-608. [PubMed: 18852293] [MGI Ref ID J:141103]
Kacha AK; Fallarino F; Markiewicz MA; Gajewski TF. 2000. Spontaneous rejection of poorly immunogenic P1.HTR tumors by Stat6-deficient mice J Immunol 165(11):6024-8. [PubMed: 11086033] [MGI Ref ID J:65893]
Kaplan MH; Wurster AL; Grusby MJ. 1998. A signal transducer and activator of transcription (Stat)4-independent pathway for the development of T helper type 1 cells. J Exp Med 188(6):1191-6. [PubMed: 9743537] [MGI Ref ID J:50032]
Kaplan MH; Wurster AL; Smiley ST; Grusby MJ. 1999. Stat6-dependent and -independent pathways for IL-4 production. J Immunol 163(12):6536-40. [PubMed: 10586046] [MGI Ref ID J:112135]
Kato A; Yoshidome H; Edwards MJ; Lentsch AB. 2000. Regulation of liver inflammatory injury by signal transducer and activator of transcription-6. Am J Pathol 157(1):297-302. [PubMed: 10880399] [MGI Ref ID J:63136]
Ketavarapu JM; Rodriguez AR; Yu JJ; Cong Y; Murthy AK; Forsthuber TG; Guentzel MN; Klose KE; Berton MT; Arulanandam BP. 2008. Mast cells inhibit intramacrophage Francisella tularensis replication via contact and secreted products including IL-4. Proc Natl Acad Sci U S A 105(27):9313-8. [PubMed: 18591675] [MGI Ref ID J:138191]
Khaled WT; Read EK; Nicholson SE; Baxter FO; Brennan AJ; Came PJ; Sprigg N; McKenzie AN; Watson CJ. 2007. The IL-4/IL-13/Stat6 signalling pathway promotes luminal mammary epithelial cell development. Development 134(15):2739-50. [PubMed: 17611223] [MGI Ref ID J:124116]
King SB; Knorn AM; Ohnmacht C; Voehringer D. 2008. Accumulation of effector CD4 T cells during type 2 immune responses is negatively regulated by Stat6. J Immunol 180(2):754-63. [PubMed: 18178813] [MGI Ref ID J:130967]
Kishimoto K; Dong VM; Issazadeh S; Fedoseyeva EV; Waaga AM; Yamada A; Sho M; Benichou G; Auchincloss H Jr; Grusby MJ; Khoury SJ; Sayegh MH. 2000. The role of CD154-CD40 versus CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo. J Clin Invest 106(1):63-72. [PubMed: 10880049] [MGI Ref ID J:63156]
Kriebel P; Patel BK; Nelson SA; Grusby MJ; LaRochelle WJ. 1999. Consequences of Stat6 deletion on Sis/PDGF- and IL-4-induced proliferation and transcriptional activation in murine fibroblasts. Oncogene 18(51):7294-302. [PubMed: 10602484] [MGI Ref ID J:59015]
Kuperman D; Schofield B; Wills-Karp M; Grusby MJ. 1998. Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production. J Exp Med 187(6):939-48. [PubMed: 9500796] [MGI Ref ID J:66222]
Kuperman DA; Huang X; Koth LL; Chang GH; Dolganov GM; Zhu Z; Elias JA; Sheppard D; Erle DJ. 2002. Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat Med 8(8):885-9. [PubMed: 12091879] [MGI Ref ID J:132385]
Kusmartsev S; Gabrilovich DI. 2005. STAT1 signaling regulates tumor-associated macrophage-mediated T cell deletion. J Immunol 174(8):4880-91. [PubMed: 15814715] [MGI Ref ID J:109996]
Land KJ; Gudapati P; Kaplan MH; Seetharamaiah GS. 2006. Differential requirement of signal transducer and activator of transcription-4 (Stat4) and Stat6 in a thyrotropin receptor-289-adenovirus-induced model of Graves' hyperthyroidism. Endocrinology 147(1):111-9. [PubMed: 16195404] [MGI Ref ID J:129448]
Le Saux CJ; Teeters K; Miyasato SK; Hoffmann PR; Bollt O; Douet V; Shohet RV; Broide DH; Tam EK. 2008. Down-regulation of caveolin-1, an inhibitor of transforming growth factor-beta signaling, in acute allergen-induced airway remodeling. J Biol Chem 283(9):5760-8. [PubMed: 18056268] [MGI Ref ID J:132297]
Lee CG; Homer RJ; Cohn L; Link H; Jung S; Craft JE; Graham BS; Johnson TR; Elias JA. 2002. Transgenic overexpression of interleukin (IL)-10 in the lung causes mucus metaplasia, tissue inflammation, and airway remodeling via IL-13-dependent and -independent pathways. J Biol Chem 277(38):35466-74. [PubMed: 12107190] [MGI Ref ID J:79116]
Lee PJ; Zhang X; Shan P; Ma B; Lee CG; Homer RJ; Zhu Z; Rincon M; Mossman BT; Elias JA. 2006. ERK1/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo. J Clin Invest 116(1):163-73. [PubMed: 16374521] [MGI Ref ID J:105338]
Levings MK; Schrader JW. 1999. IL-4 inhibits the production of TNF-alpha and IL-12 by STAT6-dependent and -independent mechanisms. J Immunol 162(9):5224-9. [PubMed: 10227996] [MGI Ref ID J:112259]
Li W; Sofi MH; Yeh N; Sehra S; McCarthy BP; Patel DR; Brutkiewicz RR; Kaplan MH; Chang CH. 2007. Thymic selection pathway regulates the effector function of CD4 T cells. J Exp Med 204(9):2145-57. [PubMed: 17724129] [MGI Ref ID J:126084]
Lin W; Truong N; Grossman WJ; Haribhai D; Williams CB; Wang J; Martin MG; Chatila TA. 2005. Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice. J Allergy Clin Immunol 116(5):1106-15. [PubMed: 16275384] [MGI Ref ID J:117165]
Linehan LA; Warren WD; Thompson PA; Grusby MJ; Berton MT. 1998. STAT6 is required for IL-4-induced germline Ig gene transcription and switch recombination. J Immunol 161(1):302-10. [PubMed: 9647237] [MGI Ref ID J:110888]
Liu Q; Arseculeratne C; Liu Z; Whitmire J; Grusby MJ; Finkelman FD; Darling TN; Cheever AW; Swearengen J; Urban JF; Gause WC. 2004. Simultaneous deficiency in CD28 and STAT6 results in chronic ectoparasite-induced inflammatory skin disease. Infect Immun 72(7):3706-15. [PubMed: 15213110] [MGI Ref ID J:90987]
Madden KB; Whitman L; Sullivan C; Gause WC; Urban JF Jr; Katona IM; Finkelman FD; Shea-Donohue T. 2002. Role of STAT6 and mast cells in IL-4- and IL-13-induced alterations in murine intestinal epithelial cell function. J Immunol 169(8):4417-22. [PubMed: 12370375] [MGI Ref ID J:120045]
Madden KB; Yeung KA; Zhao A; Gause WC; Finkelman FD; Katona IM; Urban JF Jr; Shea-Donohue T. 2004. Enteric nematodes induce stereotypic STAT6-dependent alterations in intestinal epithelial cell function. J Immunol 172(9):5616-21. [PubMed: 15100305] [MGI Ref ID J:89646]
Maerten P; Shen C; Bullens DM; Van Assche G; Van Gool S; Geboes K; Rutgeerts P; Ceuppens JL. 2005. Effects of interleukin 4 on CD25+CD4+ regulatory T cell function. J Autoimmun 25(2):112-20. [PubMed: 16051465] [MGI Ref ID J:102760]
Mathew A; MacLean JA; DeHaan E; Tager AM; Green FH; Luster AD. 2001. Signal transducer and activator of transcription 6 controls chemokine production and T helper cell type 2 cell trafficking in allergic pulmonary inflammation. J Exp Med 193(9):1087-96. [PubMed: 11342593] [MGI Ref ID J:120521]
Matsukawa A; Kaplan MH; Hogaboam CM; Lukacs NW; Kunkel SL. 2001. Pivotal role of signal transducer and activator of transcription (stat)4 and stat6 in the innate immune response during sepsis. J Exp Med 193(6):679-88. [PubMed: 11257135] [MGI Ref ID J:68143]
Mikhak Z; Fleming CM; Medoff BD; Thomas SY; Tager AM; Campanella GS; Luster AD. 2006. STAT1 in peripheral tissue differentially regulates homing of antigen-specific Th1 and Th2 cells. J Immunol 176(8):4959-67. [PubMed: 16585592] [MGI Ref ID J:131153]
Mishra A; Wang M; Schlotman J; Nikolaidis NM; DeBrosse CW; Karow ML; Rothenberg ME. 2007. Resistin-like molecule-beta is an allergen-induced cytokine with inflammatory and remodeling activity in the murine lung. Am J Physiol Lung Cell Mol Physiol 293(2):L305-13. [PubMed: 17545488] [MGI Ref ID J:125839]
Moreno JL; Mikhailenko I; Tondravi MM; Keegan AD. 2007. IL-4 promotes the formation of multinucleated giant cells from macrophage precursors by a STAT6-dependent, homotypic mechanism: contribution of E-cadherin. J Leukoc Biol 82(6):1542-53. [PubMed: 17855502] [MGI Ref ID J:129938]
Morimoto M; Morimoto M; Zhao A; Madden KB; Dawson H; Finkelman FD; Mentink-Kane M; Urban JF Jr; Wynn TA; Shea-Donohue T. 2006. Functional importance of regional differences in localized gene expression of receptors for IL-13 in murine gut. J Immunol 176(1):491-5. [PubMed: 16365442] [MGI Ref ID J:126259]
Morimoto Y; Bian Y; Gao P; Yashiro-Ohtani Y; Zhou XY; Ono S; Nakahara H; Kogo M; Hamaoka T; Fujiwara H. 2005. Induction of surface CCR4 and its functionality in mouse Th2 cells is regulated differently during Th2 development. J Leukoc Biol 78(3):753-61. [PubMed: 16126843] [MGI Ref ID J:100501]
Morris SC; Orekhova T; Meadows MJ; Heidorn SM; Yang J; Finkelman FD. 2006. IL-4 induces in vivo production of IFN-gamma by NK and NKT cells. J Immunol 176(9):5299-305. [PubMed: 16621996] [MGI Ref ID J:131660]
Morse HC 3rd; McCarty T; Giese NA; Taddesse-Heath L; Grusby MJ. 1999. STAT6-deficient mice exhibit normal induction of murine AIDS and expression of immunoglobulin E following infection with LP-BM5 murine leukemia viruses. J Virol 73(8):7093-5. [PubMed: 10400816] [MGI Ref ID J:56313]
Munitz A; McBride ML; Bernstein JS; Rothenberg ME. 2008. A dual activation and inhibition role for the paired immunoglobulin-like receptor B in eosinophils. Blood 111(12):5694-703. [PubMed: 18316626] [MGI Ref ID J:136634]
Nandakumar KS; Holmdahl R. 2006. Arthritis induced with cartilage-specific antibodiesis IL-4-dependent. Eur J Immunol 36(6):1608-18. [PubMed: 16688680] [MGI Ref ID J:115066]
Nikolic B; Lee S; Bronson RT; Grusby MJ; Sykes M. 2000. Th1 and Th2 mediate acute graft-versus-host disease, each with distinct end-organ targets. J Clin Invest 105(9):1289-98. [PubMed: 10792004] [MGI Ref ID J:62114]
Nurieva RI; Chung Y; Hwang D; Yang XO; Kang HS; Ma L; Wang YH; Watowich SS; Jetten AM; Tian Q; Dong C. 2008. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 29(1):138-49. [PubMed: 18599325] [MGI Ref ID J:137869]
Ong CJ; Ip S; Teh SJ; Wong C; Jirik FR; Grusby MJ; Teh HS. 1999. A role for T helper 2 cells in mediating skin fibrosis in tight-skin mice. Cell Immunol 196(1):60-8. [PubMed: 10486156] [MGI Ref ID J:57957]
Ostrand-Rosenberg S; Clements VK; Terabe M; Park JM; Berzofsky JA; Dissanayake SK. 2002. Resistance to metastatic disease in STAT6-deficient mice requires hemopoietic and nonhemopoietic cells and is IFN-gamma dependent. J Immunol 169(10):5796-804. [PubMed: 12421960] [MGI Ref ID J:80028]
Ostrand-Rosenberg S; Grusby MJ; Clements VK. 2000. Cutting edge: STAT6-deficient mice have enhanced tumor immunity to primary and metastatic mammary carcinoma J Immunol 165(11):6015-9. [PubMed: 11086031] [MGI Ref ID J:65894]
Ostrand-Rosenberg S; Sinha P; Clements V; Dissanayake SI; Miller S; Davis C; Danna E. 2004. Signal transducer and activator of transcription 6 (Stat6) and CD1: inhibitors of immunosurveillance against primary tumors and metastatic disease. Cancer Immunol Immunother 53(2):86-91. [PubMed: 14593499] [MGI Ref ID J:86509]
Ouyang W; Ranganath SH; Weindel K; Bhattacharya D; Murphy TL; Sha WC; Murphy KM. 1998. Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism. Immunity 9(5):745-55. [PubMed: 9846495] [MGI Ref ID J:51355]
Palmqvist P; Lundberg P; Persson E; Johansson A; Lundgren I; Lie A; Conaway HH; Lerner UH. 2006. Inhibition of hormone and cytokine-stimulated osteoclastogenesis and bone resorption by interleukin-4 and interleukin-13 is associated with increased osteoprotegerin and decreased RANKL and RANK in a STAT6-dependent pathway. J Biol Chem 281(5):2414-29. [PubMed: 16251181] [MGI Ref ID J:107499]
Park JH; Adoro S; Lucas PJ; Sarafova SD; Alag AS; Doan LL; Erman B; Liu X; Ellmeier W; Bosselut R; Feigenbaum L; Singer A. 2007. 'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR. Nat Immunol 8(10):1049-59. [PubMed: 17873878] [MGI Ref ID J:125259]
Patel DR; Li W; Park JS; Sofi MH; Gourley TS; Hangoc G; Kaplan MH; Chang CH. 2005. Constitutive expression of CIITA directs CD4 T cells to produce Th2 cytokines in the thymus. Cell Immunol 233(1):30-40. [PubMed: 15876426] [MGI Ref ID J:99357]
Reece JJ; Siracusa MC; Southard TL; Brayton CF; Urban JF Jr; Scott AL. 2008. Hookworm-induced persistent changes to the immunological environment of the lung. Infect Immun 76(8):3511-24. [PubMed: 18505812] [MGI Ref ID J:139393]
Reese TA; Liang HE; Tager AM; Luster AD; Van Rooijen N; Voehringer D; Locksley RM. 2007. Chitin induces accumulation in tissue of innate immune cells associated with allergy. Nature 447(7140):92-6. [PubMed: 17450126] [MGI Ref ID J:122735]
Rodriguez M; Zoecklein L; Gamez JD; Pavelko KD; Papke LM; Nakane S; Howe C; Radhakrishnan S; Hansen MJ; David CS; Warrington AE; Pease LR. 2006. STAT4- and STAT6-signaling molecules in a murine model of multiple sclerosis. FASEB J 20(2):343-5. [PubMed: 16352646] [MGI Ref ID J:105734]
Rodriguez-Galan MC; Bream JH; Farr A; Young HA. 2005. Synergistic effect of IL-2, IL-12, and IL-18 on thymocyte apoptosis and Th1/Th2 cytokine expression. J Immunol 174(5):2796-804. [PubMed: 15728489] [MGI Ref ID J:97710]
Rodriguez-Sosa M; David JR; Bojalil R; Satoskar AR; Terrazas LI. 2002. Cutting edge: susceptibility to the larval stage of the Helminth parasite Taenia crassiceps is mediated by Th2 response induced via STAT6 signaling. J Immunol 168(7):3135-9. [PubMed: 11907063] [MGI Ref ID J:75481]
Rosas LE; Keiser T; Barbi J; Satoskar AA; Septer A; Kaczmarek J; Lezama-Davila CM; Satoskar AR. 2005. Genetic background influences immune responses and disease outcome of cutaneous L. mexicana infection in mice. Int Immunol 17(10):1347-57. [PubMed: 16141242] [MGI Ref ID J:101701]
Rose S; Guevara P; Farach S; Adkins B. 2006. The key regulators of adult T helper cell responses, STAT6 and T-bet, are established in early life in mice. Eur J Immunol 36(5):1241-53. [PubMed: 16568497] [MGI Ref ID J:114781]
Sanchez-Guajardo V; Borghans JA; Marquez ME; Garcia S; Freitas AA. 2005. Different competitive capacities of Stat4- and Stat6-deficient CD4+ T cells during lymphophenia-driven proliferation. J Immunol 174(3):1178-87. [PubMed: 15661871] [MGI Ref ID J:96425]
Sasaki K; Zhao X; Pardee AD; Ueda R; Fujita M; Sehra S; Kaplan MH; Kane LP; Okada H; Storkus WJ. 2008. Stat6 signaling suppresses VLA-4 expression by CD8+ T cells and limits their ability to infiltrate tumor lesions in vivo. J Immunol 181(1):104-8. [PubMed: 18566374] [MGI Ref ID J:137362]
Sehra S; Patel D; Kusam S; Wang ZY; Chang CH; Dent AL. 2005. A role for caspases in controlling IL-4 expression in T cells. J Immunol 174(6):3440-6. [PubMed: 15749878] [MGI Ref ID J:128888]
Shen R; Kaplan MH. 2002. The homeostasis but not the differentiation of T cells is regulated by p27(Kip1). J Immunol 169(2):714-21. [PubMed: 12097373] [MGI Ref ID J:123837]
Shen XD; Ke B; Zhai Y; Gao F; Anselmo D; Lassman CR; Busuttil RW; Kupiec-Weglinski JW. 2003. Stat4 and Stat6 signaling in hepatic ischemia/reperfusion injury in mice: HO-1 dependence of Stat4 disruption-mediated cytoprotection. Hepatology 37(2):296-303. [PubMed: 12540779] [MGI Ref ID J:105818]
Shi HN; Grusby MJ; Nagler-Anderson C. 1999. Orally induced peripheral nonresponsiveness is maintained in the absence of functional Th1 or Th2 cells. J Immunol 162(9):5143-8. [PubMed: 10227985] [MGI Ref ID J:112262]
Shirey KA; Cole LE; Keegan AD; Vogel SN. 2008. Francisella tularensis live vaccine strain induces macrophage alternative activation as a survival mechanism. J Immunol 181(6):4159-67. [PubMed: 18768873] [MGI Ref ID J:139088]
Sho M; Yamada A; Najafian N; Salama AD; Harada H; Sandner SE; Sanchez-Fueyo A; Zheng XX; Strom TB; Sayegh MH. 2002. Physiological mechanisms of regulating alloimmunity: cytokines, CTLA-4, CD25+ cells, and the alloreactive T cell clone size. J Immunol 169(7):3744-51. [PubMed: 12244168] [MGI Ref ID J:120408]
Simovic MO; Ballard BR; Gray KD; Stain SC. 2007. The STAT4 and STAT6 pathways in pancreatitis-associated lung injury. J Surg Res 137(1):10-5. [PubMed: 17109890] [MGI Ref ID J:128064]
Singh RR; Saxena V; Zang S; Li L; Finkelman FD; Witte DP; Jacob CO. 2003. Differential contribution of IL-4 and STAT6 vs STAT4 to the development of lupus nephritis. J Immunol 170(9):4818-25. [PubMed: 12707364] [MGI Ref ID J:123824]
Sinha P; Clements VK; Ostrand-Rosenberg S. 2005. Interleukin-13-regulated M2 macrophages in combination with myeloid suppressor cells block immune surveillance against metastasis. Cancer Res 65(24):11743-51. [PubMed: 16357187] [MGI Ref ID J:104344]
Solymar DC; Agarwal S; Bassing CH; Alt FW; Rao A. 2002. A 3' enhancer in the IL-4 gene regulates cytokine production by Th2 cells and mast cells. Immunity 17(1):41-50. [PubMed: 12150890] [MGI Ref ID J:78089]
Spencer L; Shultz L; Rajan TV. 2001. Interleukin-4 receptor-stat6 signaling in murine infections with a tissue-dwelling nematode parasite. Infect Immun 69(12):7743-52. [PubMed: 11705956] [MGI Ref ID J:73137]
Strait RT; Morris SC; Smiley K; Urban JF Jr; Finkelman FD. 2003. IL-4 exacerbates anaphylaxis. J Immunol 170(7):3835-42. [PubMed: 12646651] [MGI Ref ID J:125442]
Tarleton RL; Grusby MJ; Zhang L. 2000. Increased susceptibility of Stat4-deficient and enhanced resistance in Stat6-deficient mice to infection with Trypanosoma cruzi. J Immunol 165(3):1520-5. [PubMed: 10903759] [MGI Ref ID J:120438]
Tawara I; Maeda Y; Sun Y; Lowler KP; Liu C; Toubai T; McKenzie AN; Reddy P. 2008. Combined Th2 cytokine deficiency in donor T cells aggravates experimental acute graft-vs-host disease. Exp Hematol 36(8):988-96. [PubMed: 18410989] [MGI Ref ID J:139377]
Tekkanat KK; Maassab HF; Cho DS; Lai JJ; John A; Berlin A; Kaplan MH; Lukacs NW. 2001. IL-13-induced airway hyperreactivity during respiratory syncytial virus infection is STAT6 dependent. J Immunol 166(5):3542-8. [PubMed: 11207314] [MGI Ref ID J:126450]
Temann UA; Laouar Y; Eynon EE; Homer R; Flavell RA. 2007. IL9 leads to airway inflammation by inducing IL13 expression in airway epithelial cells. Int Immunol 19(1):1-10. [PubMed: 17101709] [MGI Ref ID J:118163]
Terabe M; Khanna C; Bose S; Melchionda F; Mendoza A; Mackall CL; Helman LJ; Berzofsky JA. 2006. CD1d-restricted natural killer T cells can down-regulate tumor immunosurveillance independent of interleukin-4 receptor-signal transducer and activator of transcription 6 or transforming growth factor-beta. Cancer Res 66(7):3869-75. [PubMed: 16585215] [MGI Ref ID J:108313]
Turnbull IR; Gilfillan S; Cella M; Aoshi T; Miller M; Piccio L; Hernandez M; Colonna M. 2006. Cutting edge: TREM-2 attenuates macrophage activation. J Immunol 177(6):3520-4. [PubMed: 16951310] [MGI Ref ID J:138057]
Ueno A; Cho S; Cheng L; Wang J; Hou S; Nakano H; Santamaria P; Yang Y. 2007. Transient upregulation of indoleamine 2,3-dioxygenase in dendritic cells by human chorionic gonadotropin downregulates autoimmune diabetes. Diabetes 56(6):1686-93. [PubMed: 17360980] [MGI Ref ID J:126514]
Ueno T; Habicht A; Clarkson MR; Albin MJ; Yamaura K; Boenisch O; Popoola J; Wang Y; Yagita H; Akiba H; Ansari MJ; Yang J; Turka LA; Rothstein DM; Padera RF; Najafian N; Sayegh MH. 2008. The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model. J Clin Invest 118(2):742-51. [PubMed: 18172549] [MGI Ref ID J:131045]
Villarino AV; Tato CM; Stumhofer JS; Yao Z; Cui YK; Hennighausen L; O'Shea JJ; Hunter CA. 2007. Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals. J Exp Med 204(1):65-71. [PubMed: 17227909] [MGI Ref ID J:125293]
Voehringer D; Reese TA; Huang X; Shinkai K; Locksley RM. 2006. Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system. J Exp Med 203(6):1435-46. [PubMed: 16702603] [MGI Ref ID J:124383]
Voehringer D; Stanley SA; Cox JS; Completo GC; Lowary TL; Locksley RM. 2007. Nippostrongylus brasiliensis: identification of intelectin-1 and -2 as Stat6-dependent genes expressed in lung and intestine during infection. Exp Parasitol 116(4):458-66. [PubMed: 17420014] [MGI Ref ID J:128858]
Wang J; Cho S; Ueno A; Cheng L; Xu BY; Desrosiers MD; Shi Y; Yang Y. 2008. Ligand-dependent induction of noninflammatory dendritic cells by anergic invariant NKT cells minimizes autoimmune inflammation. J Immunol 181(4):2438-45. [PubMed: 18684934] [MGI Ref ID J:140188]
Wang W; Ostlie NS; Conti-Fine BM; Milani M. 2004. The susceptibility to experimental myasthenia gravis of STAT6-/- and STAT4-/- BALB/c mice suggests a pathogenic role of Th1 cells. J Immunol 172(1):97-103. [PubMed: 14688314] [MGI Ref ID J:87570]
Wang ZY; Kusam S; Munugalavadla V; Kapur R; Brutkiewicz RR; Dent AL. 2006. Regulation of Th2 cytokine expression in NKT cells: unconventional use of Stat6, GATA-3, and NFAT2. J Immunol 176(2):880-8. [PubMed: 16393972] [MGI Ref ID J:126448]
Xu Z; Duan B; Croker BP; Morel L. 2006. STAT4 deficiency reduces autoantibody production and glomerulonephritis in a mouse model of lupus. Clin Immunol 120(2):189-98. [PubMed: 16713741] [MGI Ref ID J:113234]
Yamada A; Sheikh F; Niimi T; DeMayo FJ; Keegan AD; Donnelly RP; Kimura S. 2005. Induction of uteroglobin-related protein 2 (Ugrp2) gene expression by the Th2 cytokines IL-4 and IL-13. J Immunol 175(9):5708-15. [PubMed: 16237061] [MGI Ref ID J:119343]
Yao Y; Li W; Kaplan MH; Chang CH. 2005. Interleukin (IL)-4 inhibits IL-10 to promote IL-12 production by dendritic cells. J Exp Med 201(12):1899-903. [PubMed: 15967820] [MGI Ref ID J:99206]
Yokota N; Burne-Taney M; Racusen L; Rabb H. 2003. Contrasting roles for STAT4 and STAT6 signal transduction pathways in murine renal ischemia-reperfusion injury. Am J Physiol Renal Physiol 285(2):F319-25. [PubMed: 12709397] [MGI Ref ID J:84825]
Yu Q; Chang HC; Ahyi AN; Kaplan MH. 2008. Transcription factor-dependent chromatin remodeling of Il18r1 during Th1 and Th2 differentiation. J Immunol 181(5):3346-52. [PubMed: 18714006] [MGI Ref ID J:138949]
Zhang S; Lawless VA; Kaplan MH. 2000. Cytokine-stimulated T lymphocyte proliferation is regulated by p27Kip1. J Immunol 165(11):6270-7. [PubMed: 11086062] [MGI Ref ID J:112128]
Zhang Y; Kirken RA; Furian L; Janczewska S; Qu X; Hancock WW; Wang M; Tejpal N; Kerman R; Kahan BD; Stepkowski SM. 2006. Allograft rejection requires STAT5a/b-regulated antiapoptotic activity in T cells but not B cells. J Immunol 176(1):128-37. [PubMed: 16365403] [MGI Ref ID J:126249]
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Zimmermann N; Mishra A; King NE; Fulkerson PC; Doepker MP; Nikolaidis NM; Kindinger LE; Moulton EA; Aronow BJ; Rothenberg ME. 2004. Transcript signatures in experimental asthma: identification of STAT6-dependent and -independent pathways. J Immunol 172(3):1815-24. [PubMed: 14734765] [MGI Ref ID J:107368]
Health & husbandry
Health & Colony Maintenance Information
Colony Maintenance
Breeding & Husbandry A footpad injection of Complete Freund s Adjuvant (CFA) administered once at weaning will delay diabetes onset, thus extending the lifespan of breeders. Use of Complete Freund s Adjuvant in NOD mice can be found in Current Protocols in Immunology page 15.9.19, Reproduction. Diet Information LabDiet® 5K52/5K67
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| 001976 NOD/ShiLtJ | ||
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| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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