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Common Names: Stat6-;    


The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names NOD.129S2-Stat6tm1Gru/JbsJ    (Changed: 15-DEC-04 )
Type Congenic; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain NOD/ShiLtJ
Donor Strain 129S2 (D3 ES cell derived)
H2 Haplotypeg7
Donating InvestigatorDr. Jeffrey A. Bluestone,   University of California, San Francisco

pink-eyed albino
Related Genotype: A/A Tyrc/Tyrc

NOD mice homozygous for the Stat6tm1Gru mutation exhibit an increased diabetes incidence compared to NOD controls and show a striking defect in the generation of Th2 cells. Lymphocytes are unable to respond to IL4 as measured in a variety of in vitro and in vivo assays. This strain can be used to look at the role of Il4 in diabetes development.

Control Information

   001976 NOD/ShiLtJ
  Considerations for Choosing Controls

Related Strains

Strains carrying   Stat6tm1Gru allele
005977   B6.129S2(C)-Stat6tm1Gru/J
003750   C.129S2-Stat4tm1Gru Stat6tm1Gru/J
002828   C.129S2-Stat6tm1Gru/J
View Strains carrying   Stat6tm1Gru     (3 strains)


Phenotype Information

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Cancer Research
Growth Factors/Receptors/Cytokines

Diabetes and Obesity Research
Type 1 Diabetes (IDDM)
Type 1 Diabetes (IDDM) Analysis Strains
      NOD Congenics with Mutations Affecting Cytokine Production by Autoreactive T Cells

Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Growth Factors/Receptors/Cytokines

Stat6tm1Gru related

Immunology, Inflammation and Autoimmunity Research
Intracellular Signaling Molecules

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol Stat6tm1Gru
Allele Name targeted mutation 1, Michael J Grusby
Allele Type Targeted (Null/Knockout)
Common Name(s) S6KO; Stat6-;
Mutation Made ByDr. Michael Grusby,   Harvard Medical School
Strain of Origin129S2/SvPas
ES Cell Line NameD3
ES Cell Line Strain129S2/SvPas
Gene Symbol and Name Stat6, signal transducer and activator of transcription 6
Chromosome 10
Gene Common Name(s) D12S1644; IL-4-STAT; STAT6B; STAT6C;
Molecular Note The region encoding the SH2 domain, which is essential for dimerization, was replaced by the insertion of a neomycin selection cassette. Immunoblot analysis of lysates from the spleens and thymi of homozygous mutant mice showed an absence of encoded protein. [MGI Ref ID J:31932]


Genotyping Information

Genotyping Protocols

Stat6tm1Gru, MELT

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Selected Reference(s)

Kaplan MH; Schindler U; Smiley ST; Grusby MJ. 1996. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity 4(3):313-9. [PubMed: 8624821]  [MGI Ref ID J:31932]

Additional References

Stat6tm1Gru related

Agarwal S; Rao A. 1998. Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation. Immunity 9(6):765-75. [PubMed: 9881967]  [MGI Ref ID J:51833]

Amsen D; Antov A; Jankovic D; Sher A; Radtke F; Souabni A; Busslinger M; McCright B; Gridley T; Flavell RA. 2007. Direct regulation of gata3 expression determines the T helper differentiation potential of notch. Immunity 27(1):89-99. [PubMed: 17658279]  [MGI Ref ID J:123631]

Armstrong BD; Abad C; Chhith S; Cheung-Lau G; Hajji OE; Coute AC; Ngo DH; Waschek JA. 2006. Impairment of axotomy-induced pituitary adenylyl cyclase-activating peptide gene expression in T helper 2 lymphocyte-deficient mice. Neuroreport 17(3):309-12. [PubMed: 16462603]  [MGI Ref ID J:106085]

Beiting DP; Gagliardo LF; Hesse M; Bliss SK; Meskill D; Appleton JA. 2007. Coordinated control of immunity to muscle stage Trichinella spiralis by IL-10, regulatory T cells, and TGF-beta. J Immunol 178(2):1039-47. [PubMed: 17202367]  [MGI Ref ID J:142622]

Bell BD; Kitajima M; Larson RP; Stoklasek TA; Dang K; Sakamoto K; Wagner KU; Reizis B; Hennighausen L; Ziegler SF. 2013. The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses. Nat Immunol 14(4):364-71. [PubMed: 23435120]  [MGI Ref ID J:194747]

Bian K; Zhong M; Harari Y; Lai M; Weisbrodt N; Murad F. 2005. Helminth regulation of host IL-4Ralpha/Stat6 signaling: mechanism underlying NOS-2 inhibition by Trichinella spiralis. Proc Natl Acad Sci U S A 102(11):3936-41. [PubMed: 15741272]  [MGI Ref ID J:97167]

Blease K; Schuh JM; Jakubzick C; Lukacs NW; Kunkel SL; Joshi BH; Puri RK; Kaplan MH; Hogaboam CM. 2002. Stat6-deficient mice develop airway hyperresponsiveness and peribronchial fibrosis during chronic fungal asthma. Am J Pathol 160(2):481-90. [PubMed: 11839568]  [MGI Ref ID J:74497]

Bour-Jordan H; Grogan JL; Tang Q; Auger JA; Locksley RM; Bluestone JA. 2003. CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment. Nat Immunol 4(2):182-8. [PubMed: 12524538]  [MGI Ref ID J:126980]

Broadhurst MJ; Leung JM; Lim KC; Girgis NM; Gundra UM; Fallon PG; Premenko-Lanier M; McKerrow JH; McCune JM; Loke P. 2012. Upregulation of retinal dehydrogenase 2 in alternatively activated macrophages during retinoid-dependent type-2 immunity to helminth infection in mice. PLoS Pathog 8(8):e1002883. [PubMed: 22927819]  [MGI Ref ID J:195366]

Broxmeyer HE; Bruns HA; Zhang S; Cooper S; Hangoc G; McKenzie AN; Dent AL; Schindler U; Naeger LK; Hoey T; Kaplan MH. 2002. Th1 cells regulate hematopoietic progenitor cell homeostasis by production of oncostatin m. Immunity 16(6):815-25. [PubMed: 12121663]  [MGI Ref ID J:77523]

Brunn A; Mihelcic M; Carstov M; Hummel L; Geier F; Schmidt A; Saupe L; Utermohlen O; Deckert M. 2014. IL-10, IL-4, and STAT6 promote an M2 milieu required for termination of P0(106-125)-induced murine experimental autoimmune neuritis. Am J Pathol 184(10):2627-40. [PubMed: 25108223]  [MGI Ref ID J:214835]

Bunting KD; Yu WM; Bradley HL; Haviernikova E; Kelly-Welch AE; Keegan AD; Qu CK. 2004. Increased numbers of committed myeloid progenitors but not primitive hematopoietic stem/progenitors in mice lacking STAT6 expression. J Leukoc Biol 76(2):484-90. [PubMed: 15123777]  [MGI Ref ID J:91477]

Burgis S; Gessner A. 2007. Unexpected phenotype of STAT6 heterozygous mice implies distinct STAT6 dosage requirements for different IL-4 functions. Int Arch Allergy Immunol 143(4):263-8. [PubMed: 17347574]  [MGI Ref ID J:140305]

Caldwell CC; Chen Y; Goetzmann HS; Hao Y; Borchers MT; Hassett DJ; Young LR; Mavrodi D; Thomashow L; Lau GW. 2009. Pseudomonas aeruginosa exotoxin pyocyanin causes cystic fibrosis airway pathogenesis. Am J Pathol 175(6):2473-88. [PubMed: 19893030]  [MGI Ref ID J:155327]

Carty SA; Koretzky GA; Jordan MS. 2014. Interleukin-4 regulates eomesodermin in CD8+ T cell development and differentiation. PLoS One 9(9):e106659. [PubMed: 25207963]  [MGI Ref ID J:221518]

Castilow EM; Legge KL; Varga SM. 2008. Cutting edge: Eosinophils do not contribute to respiratory syncytial virus vaccine-enhanced disease. J Immunol 181(10):6692-6. [PubMed: 18981084]  [MGI Ref ID J:140954]

Chang HC; Zhang S; Kaplan MH. 2002. Neonatal tolerance in the absence of Stat4- and Stat6- dependent Th cell differentiation. J Immunol 169(8):4124-8. [PubMed: 12370340]  [MGI Ref ID J:120160]

Chang HH; Miaw SC; Tseng W; Sun YW; Liu CC; Tsao HW; Ho IC. 2013. PTPN22 modulates macrophage polarization and susceptibility to dextran sulfate sodium-induced colitis. J Immunol 191(5):2134-43. [PubMed: 23913970]  [MGI Ref ID J:205805]

Chang S; Aune TM. 2007. Dynamic changes in histone-methylation 'marks' across the locus encoding interferon-gamma during the differentiation of T helper type 2 cells. Nat Immunol 8(7):723-31. [PubMed: 17546034]  [MGI Ref ID J:123355]

Chapoval SP; Al-Garawi A; Lora JM; Strickland I; Ma B; Lee PJ; Homer RJ; Ghosh S; Coyle AJ; Elias JA. 2007. Inhibition of NF-kappaB activation reduces the tissue effects of transgenic IL-13. J Immunol 179(10):7030-41. [PubMed: 17982094]  [MGI Ref ID J:154009]

Chapoval SP; Dasgupta P; Smith EP; DeTolla LJ; Lipsky MM; Kelly-Welch AE; Keegan AD. 2011. STAT6 expression in multiple cell types mediates the cooperative development of allergic airway disease. J Immunol 186(4):2571-83. [PubMed: 21242523]  [MGI Ref ID J:169153]

Chen CC; Louie S; McCormick B; Walker WA; Shi HN. 2005. Concurrent infection with an intestinal helminth parasite impairs host resistance to enteric Citrobacter rodentium and enhances Citrobacter-induced colitis in mice. Infect Immun 73(9):5468-81. [PubMed: 16113263]  [MGI Ref ID J:100416]

Chen H; Sun H; You F; Sun W; Zhou X; Chen L; Yang J; Wang Y; Tang H; Guan Y; Xia W; Gu J; Ishikawa H; Gutman D; Barber G; Qin Z; Jiang Z. 2011. Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity. Cell 147(2):436-46. [PubMed: 22000020]  [MGI Ref ID J:177502]

Chen Z; Lund R; Aittokallio T; Kosonen M; Nevalainen O; Lahesmaa R. 2003. Identification of novel IL-4/Stat6-regulated genes in T lymphocytes. J Immunol 171(7):3627-35. [PubMed: 14500660]  [MGI Ref ID J:107367]

Cheng LE; Wang ZE; Locksley RM. 2010. Murine B cells regulate serum IgE levels in a CD23-dependent manner. J Immunol 185(9):5040-7. [PubMed: 20870945]  [MGI Ref ID J:165198]

Chesler DA; Reiss CS. 2002. IL-12, while beneficial, is not essential for the host response to VSV encephalitis. J Neuroimmunol 131(1-2):92-7. [PubMed: 12458040]  [MGI Ref ID J:102956]

Chitnis T; Najafian N; Benou C; Salama AD; Grusby MJ; Sayegh MH; Khoury SJ. 2001. Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis. J Clin Invest 108(5):739-47. [PubMed: 11544280]  [MGI Ref ID J:71460]

Chitnis T; Salama AD; Grusby MJ; Sayegh MH; Khoury SJ. 2004. Defining Th1 and Th2 immune responses in a reciprocal cytokine environment in vivo. J Immunol 172(7):4260-5. [PubMed: 15034039]  [MGI Ref ID J:88725]

Chung DR; Kasper DL; Panzo RJ; Chtinis T; Grusby MJ; Sayegh MH; Tzianabos AO. 2003. CD4+ T cells mediate abscess formation in intra-abdominal sepsis by an IL-17-dependent mechanism. J Immunol 170(4):1958-63. [PubMed: 12574364]  [MGI Ref ID J:81809]

Cooney LA; Towery K; Endres J; Fox DA. 2011. Sensitivity and resistance to regulation by IL-4 during Th17 maturation. J Immunol 187(9):4440-50. [PubMed: 21949021]  [MGI Ref ID J:179441]

Cruz-Guilloty F; Saeed AM; Duffort S; Cano M; Ebrahimi KB; Ballmick A; Tan Y; Wang H; Laird JM; Salomon RG; Handa JT; Perez VL. 2014. T cells and macrophages responding to oxidative damage cooperate in pathogenesis of a mouse model of age-related macular degeneration. PLoS One 9(2):e88201. [PubMed: 24586307]  [MGI Ref ID J:213342]

Cunnusamy K; Chen PW; Niederkorn JY. 2010. IL-17 promotes immune privilege of corneal allografts. J Immunol 185(8):4651-8. [PubMed: 20844197]  [MGI Ref ID J:164882]

Dardalhon V; Awasthi A; Kwon H; Galileos G; Gao W; Sobel RA; Mitsdoerffer M; Strom TB; Elyaman W; Ho IC; Khoury S; Oukka M; Kuchroo VK. 2008. IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells. Nat Immunol 9(12):1347-55. [PubMed: 18997793]  [MGI Ref ID J:143168]

Das J; Ren G; Zhang L; Roberts AI; Zhao X; Bothwell AL; Van Kaer L; Shi Y; Das G. 2009. Transforming growth factor beta is dispensable for the molecular orchestration of Th17 cell differentiation. J Exp Med 206(11):2407-16. [PubMed: 19808254]  [MGI Ref ID J:154176]

Devoss JJ; Shum AK; Johannes KP; Lu W; Krawisz AK; Wang P; Yang T; Leclair NP; Austin C; Strauss EC; Anderson MS. 2008. Effector mechanisms of the autoimmune syndrome in the murine model of autoimmune polyglandular syndrome type 1. J Immunol 181(6):4072-9. [PubMed: 18768863]  [MGI Ref ID J:139094]

Dickgreber N; Farrand KJ; van Panhuys N; Knight DA; McKee SJ; Chong ML; Miranda-Hernandez S; Baxter AG; Locksley RM; Le Gros G; Hermans IF. 2012. Immature murine NKT cells pass through a stage of developmentally programmed innate IL-4 secretion. J Leukoc Biol 92(5):999-1009. [PubMed: 22941735]  [MGI Ref ID J:190015]

Doherty TA; Khorram N; Sugimoto K; Sheppard D; Rosenthal P; Cho JY; Pham A; Miller M; Croft M; Broide DH. 2012. Alternaria Induces STAT6-Dependent Acute Airway Eosinophilia and Epithelial FIZZ1 Expression That Promotes Airway Fibrosis and Epithelial Thickness. J Immunol 188(6):2622-9. [PubMed: 22327070]  [MGI Ref ID J:181849]

Dorsey NJ; Chapoval SP; Smith EP; Skupsky J; Scott DW; Keegan AD. 2013. STAT6 controls the number of regulatory T cells in vivo, thereby regulating allergic lung inflammation. J Immunol 191(4):1517-28. [PubMed: 23825312]  [MGI Ref ID J:205707]

Eddahri F; Denanglaire S; Bureau F; Spolski R; Leonard WJ; Leo O; Andris F. 2009. Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities. Blood 113(11):2426-33. [PubMed: 19020307]  [MGI Ref ID J:146334]

Fang TC; Yashiro-Ohtani Y; Del Bianco C; Knoblock DM; Blacklow SC; Pear WS. 2007. Notch directly regulates Gata3 expression during T helper 2 cell differentiation. Immunity 27(1):100-10. [PubMed: 17658278]  [MGI Ref ID J:123632]

Fichtner-Feigl S; Kesselring R; Martin M; Obermeier F; Ruemmele P; Kitani A; Brunner SM; Haimerl M; Geissler EK; Strober W; Schlitt HJ. 2014. IL-13 orchestrates resolution of chronic intestinal inflammation via phosphorylation of glycogen synthase kinase-3beta. J Immunol 192(8):3969-80. [PubMed: 24634488]  [MGI Ref ID J:210014]

Finkelman FD; Morris SC; Orekhova T; Mori M; Donaldson D; Reiner SL; Reilly NL; Schopf L; Urban JF Jr. 2000. Stat6 regulation of in vivo IL-4 responses. J Immunol 164(5):2303-10. [PubMed: 10679064]  [MGI Ref ID J:112038]

Finnegan A; Grusby MJ; Kaplan CD; O'Neill SK; Eibel H; Koreny T; Czipri M; Mikecz K; Zhang J. 2002. IL-4 and IL-12 regulate proteoglycan-induced arthritis through Stat-dependent mechanisms. J Immunol 169(6):3345-52. [PubMed: 12218156]  [MGI Ref ID J:120443]

Fraidakis MJ; Kiyotani T; Pernold K; Bergstrom J; Olson L. 2007. Recovery from spinal cord injury in tumor necrosis factor-alpha, signal transducers and activators of transcription 4 and signal transducers and activators of transcription 6 null mice. Neuroreport 18(2):185-9. [PubMed: 17301687]  [MGI Ref ID J:120345]

Gallo E; Katzman S; Villarino AV. 2012. IL-13-producing Th1 and Th17 cells characterize adaptive responses to both self and foreign antigens. Eur J Immunol 42(9):2322-8. [PubMed: 22684943]  [MGI Ref ID J:187947]

Ghiasi H; Osorio Y; Nesburn AB; Wechsler SL. 2002. Enhanced clearance of herpes simplex virus type 1 and reduced herpetic eye disease in STAT6 knockout mice is associated with increased IL-2. Virology 302(2):286-93. [PubMed: 12441072]  [MGI Ref ID J:107370]

Goren I; Pfeilschifter J; Frank S. 2014. Uptake of neutrophil-derived ym1 protein distinguishes wound macrophages in the absence of interleukin-4 signaling in murine wound healing. Am J Pathol 184(12):3249-61. [PubMed: 25307347]  [MGI Ref ID J:216580]

Goswami R; Jabeen R; Yagi R; Pham D; Zhu J; Goenka S; Kaplan MH. 2012. STAT6-dependent regulation of Th9 development. J Immunol 188(3):968-75. [PubMed: 22180613]  [MGI Ref ID J:180779]

Goswami S; Angkasekwinai P; Shan M; Greenlee KJ; Barranco WT; Polikepahad S; Seryshev A; Song LZ; Redding D; Singh B; Sur S; Woodruff P; Dong C; Corry DB; Kheradmand F. 2009. Divergent functions for airway epithelial matrix metalloproteinase 7 and retinoic acid in experimental asthma. Nat Immunol 10(5):496-503. [PubMed: 19329997]  [MGI Ref ID J:148285]

Guenova E; Skabytska Y; Hoetzenecker W; Weindl G; Sauer K; Tham M; Kim KW; Park JH; Seo JH; Ignatova D; Cozzio A; Levesque MP; Volz T; Koberle M; Kaesler S; Thomas P; Mailhammer R; Ghoreschi K; Schakel K; Amarov B; Eichner M; Schaller M; Clark RA; RockenM; Biedermann T. 2015. IL-4 abrogates T(H)17 cell-mediated inflammation by selective silencing of IL-23 in antigen-presenting cells. Proc Natl Acad Sci U S A 112(7):2163-8. [PubMed: 25646481]  [MGI Ref ID J:219998]

Gundra UM; Girgis NM; Ruckerl D; Jenkins S; Ward LN; Kurtz ZD; Wiens KE; Tang MS; Basu-Roy U; Mansukhani A; Allen JE; Loke P. 2014. Alternatively activated macrophages derived from monocytes and tissue macrophages are phenotypically and functionally distinct. Blood 123(20):e110-22. [PubMed: 24695852]  [MGI Ref ID J:212404]

Guo B; Rothstein TL. 2013. IL-4 upregulates Igalpha and Igbeta protein, resulting in augmented IgM maturation and B cell receptor-triggered B cell activation. J Immunol 191(2):670-7. [PubMed: 23776171]  [MGI Ref ID J:205452]

Guseh JS; Bores SA; Stanger BZ; Zhou Q; Anderson WJ; Melton DA; Rajagopal J. 2009. Notch signaling promotes airway mucous metaplasia and inhibits alveolar development. Development 136(10):1751-9. [PubMed: 19369400]  [MGI Ref ID J:148016]

Haapakoski R; Karisola P; Fyhrquist N; Savinko T; Wolff H; Turjanmaa K; Palosuo T; Reunala T; Lauerma A; Alenius H. 2011. Intradermal cytosine-phosphate-guanosine treatment reduces lung inflammation but induces IFN-gamma-mediated airway hyperreactivity in a murine model of natural rubber latex allergy. Am J Respir Cell Mol Biol 44(5):639-47. [PubMed: 20581096]  [MGI Ref ID J:183350]

Haczku A; Cao Y; Vass G; Kierstein S; Nath P; Atochina-Vasserman EN; Scanlon ST; Li L; Griswold DE; Chung KF; Poulain FR; Hawgood S; Beers MF; Crouch EC. 2006. IL-4 and IL-13 form a negative feedback circuit with surfactant protein-D in the allergic airway response. J Immunol 176(6):3557-65. [PubMed: 16517724]  [MGI Ref ID J:129507]

Hadeiba H; Locksley RM. 2003. Lung CD25 CD4 regulatory T cells suppress type 2 immune responses but not bronchial hyperreactivity. J Immunol 170(11):5502-10. [PubMed: 12759427]  [MGI Ref ID J:109990]

Hakim O; Sung MH; Nakayamada S; Voss TC; Baek S; Hager GL. 2013. Spatial congregation of STAT binding directs selective nuclear architecture during T-cell functional differentiation. Genome Res 23(3):462-72. [PubMed: 23212947]  [MGI Ref ID J:198013]

Han H; Headley MB; Xu W; Comeau MR; Zhou B; Ziegler SF. 2013. Thymic stromal lymphopoietin amplifies the differentiation of alternatively activated macrophages. J Immunol 190(3):904-12. [PubMed: 23275605]  [MGI Ref ID J:193032]

Han NR; Oh HA; Nam SY; Moon PD; Kim DW; Kim HM; Jeong HJ. 2014. TSLP induces mast cell development and aggravates allergic reactions through the activation of MDM2 and STAT6. J Invest Dermatol 134(10):2521-30. [PubMed: 24751726]  [MGI Ref ID J:214773]

Harrington LE; Hatton RD; Mangan PR; Turner H; Murphy TL; Murphy KM; Weaver CT. 2005. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 6(11):1123-32. [PubMed: 16200070]  [MGI Ref ID J:112601]

Harris MB; Chang CC; Berton MT; Danial NN; Zhang J; Kuehner D; Ye BH; Kvatyuk M; Pandolfi PP; Cattoretti G; Dalla-Favera R; Rothman PB. 1999. Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: specific regulation of iepsilon transcription and immunoglobulin E switching. Mol Cell Biol 19(10):7264-75. [PubMed: 10490661]  [MGI Ref ID J:57856]

Herold KC; Lu J; Rulifson I; Vezys V; Taub D; Grusby MJ; Bluestone JA. 1997. Regulation of C-C chemokine production by murine T cells by CD28/B7 costimulation. J Immunol 159(9):4150-3. [PubMed: 9379007]  [MGI Ref ID J:110673]

Holz A; Bot A; Coon B; Wolfe T; Grusby MJ; von Herrath MG. 1999. Disruption of the STAT4 signaling pathway protects from autoimmune diabetes while retaining antiviral immune competence. J Immunol 163(10):5374-82. [PubMed: 10553062]  [MGI Ref ID J:107047]

Hoshino A; Tsuji T; Matsuzaki J; Jinushi T; Ashino S; Teramura T; Chamoto K; Tanaka Y; Asakura Y; Sakurai T; Mita Y; Takaoka A; Nakaike S; Takeshima T; Ikeda H; Nishimura T. 2004. STAT6-mediated signaling in Th2-dependent allergic asthma: critical role for the development of eosinophilia, airway hyper-responsiveness and mucus hypersecretion, distinct from its role in Th2 differentiation. Int Immunol 16(10):1497-505. [PubMed: 15351784]  [MGI Ref ID J:93632]

Howell MD; Gallo RL; Boguniewicz M; Jones JF; Wong C; Streib JE; Leung DY. 2006. Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus. Immunity 24(3):341-8. [PubMed: 16546102]  [MGI Ref ID J:113325]

Huang P; Huo Y; Lou LX; Li H; Barnstable CJ; Zhang C; Zhang SS. 2013. CD4 positive T helper cells contribute to retinal ganglion cell death in mouse model of ischemia reperfusion injury. Exp Eye Res 115:131-9. [PubMed: 23792169]  [MGI Ref ID J:210412]

Huang W; Huang F; Kannan AK; Hu J; August A. 2014. ITK tunes IL-4-induced development of innate memory CD8+ T cells in a gammadelta T and invariant NKT cell-independent manner. J Leukoc Biol 96(1):55-63. [PubMed: 24620029]  [MGI Ref ID J:212002]

Huber S; Hoffmann R; Muskens F; Voehringer D. 2010. Alternatively activated macrophages inhibit T-cell proliferation by Stat6-dependent expression of PD-L2. Blood 116(17):3311-20. [PubMed: 20625006]  [MGI Ref ID J:165869]

Huber SA; Sakkinen P; David C; Newell MK; Tracy RP. 2001. T helper-cell phenotype regulates atherosclerosis in mice under conditions of mild hypercholesterolemia. Circulation 103(21):2610-6. [PubMed: 11382732]  [MGI Ref ID J:133189]

Ingram JL; Antao-Menezes A; Mangum JB; Lyght O; Lee PJ; Elias JA; Bonner JC. 2006. Opposing actions of Stat1 and Stat6 on IL-13-induced up-regulation of early growth response-1 and platelet-derived growth factor ligands in pulmonary fibroblasts. J Immunol 177(6):4141-8. [PubMed: 16951379]  [MGI Ref ID J:138041]

Iribarren P; Chen K; Hu J; Zhang X; Gong W; Wang JM. 2005. IL-4 inhibits the expression of mouse formyl peptide receptor 2, a receptor for amyloid beta1-42, in TNF-alpha-activated microglia. J Immunol 175(9):6100-6. [PubMed: 16237106]  [MGI Ref ID J:119383]

Ishii M; Wen H; Corsa CA; Liu T; Coelho AL; Allen RM; Carson WF 4th; Cavassani KA; Li X; Lukacs NW; Hogaboam CM; Dou Y; Kunkel SL. 2009. Epigenetic regulation of the alternatively activated macrophage phenotype. Blood 114(15):3244-54. [PubMed: 19567879]  [MGI Ref ID J:153569]

Ishikawa Y; Yoshimoto T; Nakanishi K. 2006. Contribution of IL-18-induced innate T cell activation to airway inflammation with mucus hypersecretion and airway hyperresponsiveness. Int Immunol 18(6):847-55. [PubMed: 16611648]  [MGI Ref ID J:109098]

Jabeen R; Goswami R; Awe O; Kulkarni A; Nguyen ET; Attenasio A; Walsh D; Olson MR; Kim MH; Tepper RS; Sun J; Kim CH; Taparowsky EJ; Zhou B; Kaplan MH. 2013. Th9 cell development requires a BATF-regulated transcriptional network. J Clin Invest :. [PubMed: 24216482]  [MGI Ref ID J:204178]

Jacob CO; Zang S; Li L; Ciobanu V; Quismorio F; Mizutani A; Satoh M; Koss M. 2003. Pivotal role of Stat4 and Stat6 in the pathogenesis of the lupus-like disease in the New Zealand mixed 2328 mice. J Immunol 171(3):1564-71. [PubMed: 12874250]  [MGI Ref ID J:120665]

Jaruga B; Hong F; Sun R; Radaeva S; Gao B. 2003. Crucial role of IL-4/STAT6 in T cell-mediated hepatitis: up-regulating eotaxins and IL-5 and recruiting leukocytes. J Immunol 171(6):3233-44. [PubMed: 12960353]  [MGI Ref ID J:85386]

Jensen KD; Hu K; Whitmarsh RJ; Hassan MA; Julien L; Lu D; Chen L; Hunter CA; Saeij JP. 2013. Toxoplasma gondii rhoptry 16 kinase promotes host resistance to oral infection and intestinal inflammation only in the context of the dense granule protein GRA15. Infect Immun 81(6):2156-67. [PubMed: 23545295]  [MGI Ref ID J:199524]

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Zhu J; Guo L; Min B; Watson CJ; Hu-Li J; Young HA; Tsichlis PN; Paul WE. 2002. Growth factor independent-1 induced by IL-4 regulates Th2 cell proliferation. Immunity 16(5):733-44. [PubMed: 12049724]  [MGI Ref ID J:113530]

Zimmermann N; Mishra A; King NE; Fulkerson PC; Doepker MP; Nikolaidis NM; Kindinger LE; Moulton EA; Aronow BJ; Rothenberg ME. 2004. Transcript signatures in experimental asthma: identification of STAT6-dependent and -independent pathways. J Immunol 172(3):1815-24. [PubMed: 14734765]  [MGI Ref ID J:107368]

van Panhuys N; Prout M; Forbes E; Min B; Paul WE; Le Gros G. 2011. Basophils Are the Major Producers of IL-4 during Primary Helminth Infection. J Immunol 186(5):2719-28. [PubMed: 21270410]  [MGI Ref ID J:169387]

van Panhuys N; Tang SC; Prout M; Camberis M; Scarlett D; Roberts J; Hu-Li J; Paul WE; Le Gros G. 2008. In vivo studies fail to reveal a role for IL-4 or STAT6 signaling in Th2 lymphocyte differentiation. Proc Natl Acad Sci U S A 105(34):12423-8. [PubMed: 18719110]  [MGI Ref ID J:138827]

van der Merwe M; Abdelsamed HA; Seth A; Ong T; Vogel P; Pillai AB. 2013. Recipient myeloid-derived immunomodulatory cells induce PD-1 ligand-dependent donor CD4+Foxp3+ regulatory T cell proliferation and donor-recipient immune tolerance after murine nonmyeloablative bone marrow transplantation. J Immunol 191(11):5764-76. [PubMed: 24190658]  [MGI Ref ID J:207149]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryA footpad injection of Complete Freund s Adjuvant (CFA) administered once at weaning will delay diabetes onset, thus extending the lifespan of breeders. Use of Complete Freund s Adjuvant in NOD mice can be found in Current Protocols in Immunology page 15.9.19, Reproduction.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

Pricing for USA, Canada and Mexico shipping destinations View International Pricing


Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2625.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $1725.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing


Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3412.50
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $2242.50

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

General Supply Notes

Control Information

   001976 NOD/ShiLtJ
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use

General Terms and Conditions

For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries regarding Terms of Use

Contracts Administration


JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty


In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.