Strain Name:

NOD.129(B6)-Rag1tm1Mom Cd80tm1Shr/JbsJ

Stock Number:

004673

Availability:

Repository-Cryopreserved

Use Restrictions Apply, see Purchasing Information

Description

Strain Information

Former Names NOD.129S7-Rag1tm1Mom Cd80tm1Shr/JbsJ    (Changed: 15-DEC-04 )
Type Congenic; Mutant Strain; Targeted Mutation;
Specieslaboratory mouse
Background Strain NOD/ShiLt
Donor Strain 129S4 (J1 Es cells)
H2 Haplotypeg7
 
Donating Investigator Jeffrey Bluestone,   University of California, San Francisco

Appearance
albino
Related Genotype: A/A Tyrc/Tyrc

Description
The NOD.129(B6)Rag1tm1MomCd80tm1Shr/JbsJ homozygous mice fail to produce T or B cells. Mice homozygous for both Rag1tm1Mom and Cd80tm1Shr are viable and fertile and exhibit no signs of diabetes due to the absence of lymphocytes.

On the NOD background Cd80tm1Shr alone exacerbates diabetes onset when compared to standard NOD controls. When injected with proteolipid protein in Complete Freund's Adjuvant, NOD mice homozygous for the Cd80tm1Shr/JbsJ mutation alone develop similar though slightly milder, experimental autoimmune encephalomyelitis (EAE) when compared with NOD controls.

NOD.129(B6)-Rag1tm1MomCd80tm1Shr/JbsJ are valuable for unraveling the co-stimulatory pathways of T cell activation as it relates to autoimmune diseases and organ transplantation.

Development
A targeting vector containing a neomycin cassette under the control of the mouse phosphoglycerol kinase (PGK1) promoter was used to disrupt in J1 (129S4) embryonic stem (ES) cells, the second exon of the Cd80 (commonly referenced as B7-1) gene encoding the IgV-like domain. ES cells were injected into C57BL/6J blastocysts. To establish a colony and germ line transmission, chimeric mice were backcrossed to 129S4, prior to intercrossing to generate mice homozygous for Cd80tm1Shr(Freeman et al, 1993). Garvin et al, 2000, backcrossed Cd80tm1Shr to NOD for 5 or more generations prior to intercrossing to make a NOD incipient congenic strain homozygous for Cd80tm1Shr Due to early onset of diabetes and the difficulties in maintaining the strain, Bluestone, et al backcrossed to NOD.129S7(B6)-Rag1tm1Mom. In 2003,NOD.129(B6)Rag1tm1MomCd80tm1Shr/Jbs arrived at The Jackson Laboratory at generation NE9F8. Once rederived into The Jackson Laboratory it was found that markers delineating the Idd13 locus are of 129 origin. NOD.129(B6)Rag1tm1MomCd80tm1Shr/JbsJ is maintained homozygous for the targeted mutations of both Cd80 and Rag1.

Control Information

  Control
   001976 NOD/ShiLtJ
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Cd80tm1Shr allele
003610   B6.129S4-Cd80tm1Shr Cd86tm2Shr/J
003611   B6.129S4-Cd80tm1Shr/J
005273   NOD.Cg-Rag1tm1Mom Cd86tm2Shr Cd80tm1Shr/JbsJ
View Strains carrying   Cd80tm1Shr     (3 strains)

View Strains carrying   Rag1tm1Mom     (16 strains)

Strains carrying other alleles of Cd80
007769   NOD.FVB-Tg(Igh-6-Cd80)1Gjf/JbsJ
006778   NOD/ShiLt-Tg(GFAP-Cd80)9Mdos/MdosJ
View Strains carrying other alleles of Cd80     (2 strains)

Strains carrying other alleles of Rag1
007790   B6;129P2-Rag1/Rag2tm1Mnz/J
002194   B6;CBA-Tg(CD3E)26Cpt/J
002506   STOCK Tg(CD3E)26Cpt-Rag1tm1Mom/J
View Strains carrying other alleles of Rag1     (3 strains)

Additional Web Information

Congenic Nomenclature
Genetic Quality Control Annual Report

Phenotype

Phenotype Information

Research Applications

This mouse can be used to support research in many areas including:

Diabetes and Obesity Research
Islet Transplantation Studies
Type 1 Diabetes (IDDM)
Type 1 Diabetes (IDDM) Analysis Strains

Immunology and Inflammation Research
Autoimmunity (Type 1 Diabetes)

Cd80tm1Shr related

Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunodeficiency Associated with Other Defects
Intracellular Signaling Molecules
Lymphoid Tissue Defects

Internal/Organ Research
Lymphoid Tissue Defects

Rag1tm1Mom related

Cancer Research
Toxicology (B and T cell deficiency) (xenograft/transplant host)

Hematological Research
Immunological Defects (B and T cell deficiency)

Immunology and Inflammation Research
Immunodeficiency (B and T cell deficiency)
Inflammation (B and T cell deficiency)
T Cell Receptor Signaling Defects (B and T cell deficiency)

Internal/Organ Research
Lymphoid Tissue Defects (B and T cell deficiency)

Research Tools
Cancer Research (B and T cell deficiency) (xenograft/transplant host)
Toxicology Research (xenograft/transplant host)

Genes & Alleles

Gene & Allele Information

Allele Symbol Cd80tm1Shr
Allele Name targeted mutation 1, Arlene H Sharpe
Common Name(s) B7-; B7-1-; B7.1; CD80-;
Mutation Made By Arlene Sharpe,   Brigham and Women's Hospital
Strain of Origin129S4/SvJae
ES Cell Line NameJ1
ES Cell Line Strain129S4/SvJae
Gene Symbol and Name Cd80, CD80 antigen
Chromosome 16
Gene Common Name(s) B7-1; B7.1; CD28 antigen ligand; CD28LG; CD28LG1; Cd28l; LAB7; Ly-53; Ly53; lymphocyte antigen 53;
Molecular Note A neomycin selection cassette replaced the exon encoding the IgV-like domain of the protein. RT-PCR analysis on RNA derived from spleen, thymus and LPS-stimulated B cells of homozygous mice demonstrated that no detectable transcript was produced from this allele. FACS analysis on B cells derived from homozygous mice confirmed that no functional protein was encoded by this allele. [MGI Ref ID J:74662]
 
Allele Symbol Rag1tm1Mom
Allele Name targeted mutation 1, Peter Mombaerts
Common Name(s) RAG-1-; RAG1null; Rag-; Rag-1KO; Rag1-;
Mutation Made By Peter Mombaerts,   Max Planck Institute of Biophysics
Strain of Origin129S7/SvEvBrd-Hprt1<+>
ES Cell Line NameAB1
ES Cell Line Strain129S7/SvEvBrd-Hprt1<+>
Gene Symbol and Name Rag1, recombination activating gene 1
Chromosome 2
Gene Common Name(s) MGC43321; RNF74; Rag-1;
Molecular Note A 1356 bp genomic fragment of the Rag1 gene, encoding the nuclear localization signal and the zinc-finger motif, was replaced by a neomycin cassette. A mutant transcript expressed from this allele was detected by Northern blot in bone marrow derived cell lines from homozygous mice. [MGI Ref ID J:1934] [MGI Ref ID J:96036]

Genotyping

Genotyping Information

Genotyping Protocols

Cd80tm1Shr, STD PCR, vers. 2
Rag1tm1Mom, STD PCR, vers. 1

Helpful Links

Optimizing PCR Protocols

References

References

Selected Reference(s)

Girvin AM; Dal Canto MC; Rhee L; Salomon B; Sharpe A; Bluestone JA; Miller SD. 2000. A critical role for B7/CD28 costimulation in experimental autoimmune encephalomyelitis: a comparative study using costimulatory molecule-deficient mice and monoclonal antibody blockade. J Immunol 164(1):136-43. [PubMed: 10605004]  [MGI Ref ID J:109892]

Additional References

Cd80tm1Shr related

Ait-Oufella H; Salomon BL; Potteaux S; Robertson AK; Gourdy P; Zoll J; Merval R; Esposito B; Cohen JL; Fisson S; Flavell RA; Hansson GK; Klatzmann D; Tedgui A; Mallat Z. 2006. Natural regulatory T cells control the development of atherosclerosis in mice. Nat Med 12(2):178-80. [PubMed: 16462800]  [MGI Ref ID J:105800]

Asai T; Choi BK; Kwon PM; Kim WY; Kim JD; Vinay DS; Gebhardt BM; Kwon BS. 2007. Blockade of the 4-1BB (CD137)/4-1BBL and/or CD28/CD80/CD86 costimulatory pathways promotes corneal allograft survival in mice. Immunology 121(3):349-58. [PubMed: 17376197]  [MGI Ref ID J:125540]

Borriello F; Sethna MP; Boyd SD; Schweitzer AN; Tivol EA; Jacoby D ; Strom TB ; Simpson EM ; Freeman GJ ; Sharpe AH. 1997. B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation. Immunity 6(3):303-13. [PubMed: 9075931]  [MGI Ref ID J:39089]

Brinster C; Shevach EM. 2005. Bone marrow-derived dendritic cells reverse the anergic state of CD4+CD25+ T cells without reversing their suppressive function. J Immunol 175(11):7332-40. [PubMed: 16301639]  [MGI Ref ID J:122138]

Buhlmann JE; Elkin SK; Sharpe AH. 2003. A Role for the B7-1/B7-2:CD28/CTLA-4 Pathway During Negative Selection. J Immunol 170(11):5421-8. [PubMed: 12759417]  [MGI Ref ID J:83454]

Chen Y; Perry D; Boackle SA; Sobel ES; Molina H; Croker BP; Morel L. 2005. Several genes contribute to the production of autoreactive B and T cells in the murine lupus susceptibility locus Sle1c. J Immunol 175(2):1080-9. [PubMed: 16002709]  [MGI Ref ID J:100702]

Chikuma S; Bluestone JA. 2007. Expression of CTLA-4 and FOXP3 in cis protects from lethal lymphoproliferative disease. Eur J Immunol 37(5):1285-9. [PubMed: 17429849]  [MGI Ref ID J:123580]

Chung Y; Nurieva R; Esashi E; Wang YH; Zhou D; Gapin L; Dong C. 2008. A critical role of costimulation during intrathymic development of invariant NK T cells. J Immunol 180(4):2276-83. [PubMed: 18250436]  [MGI Ref ID J:131999]

Detmar M; Brown LF; Schon MP; Elicker BM; Velasco P; Richard L; Fukumura D; Monsky W; Claffey KP; Jain RK. 1998. Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice. J Invest Dermatol 111(1):1-6. [PubMed: 9665379]  [MGI Ref ID J:104245]

DiPaolo RJ; Unanue ER. 2002. Cutting edge: the relative distribution of T cells responding to chemically dominant or minor epitopes of lysozyme is not affected by CD40-CD40 ligand and B7-CD28-CTLA-4 costimulatory pathways. J Immunol 169(6):2832-6. [PubMed: 12218093]  [MGI Ref ID J:120434]

Duan B; Niu H; Xu Z; Sharpe AH; Croker BP; Sobel ES; Morel L. 2008. Intrafollicular location of marginal zone/CD1d(hi) B cells is associated with autoimmune pathology in a mouse model of lupus. Lab Invest 88(9):1008-20. [PubMed: 18607347]  [MGI Ref ID J:138314]

Feuillet V; Lucas B; Di Santo JP; Bismuth G; Trautmann A. 2005. Multiple survival signals are delivered by dendritic cells to naive CD4+ T cells. Eur J Immunol 35(9):2563-72. [PubMed: 16078277]  [MGI Ref ID J:113487]

Fife BT; Griffin MD; Abbas AK; Locksley RM; Bluestone JA. 2006. Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist. J Clin Invest 116(8):2252-61. [PubMed: 16886063]  [MGI Ref ID J:113109]

Fontenot JD; Rasmussen JP; Williams LM; Dooley JL; Farr AG; Rudensky AY. 2005. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 22(3):329-41. [PubMed: 15780990]  [MGI Ref ID J:97029]

Freeman GJ; Borriello F; Hodes RJ; Reiser H; Hathcock KS; Laszlo G; McKnight AJ; Kim J; Du L; Lombard DB; et al.. 1993. Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice. Science 262(5135):907-9. [PubMed: 7694362]  [MGI Ref ID J:74662]

Fuse S; Zhang W; Usherwood EJ. 2008. Control of memory CD8+ T cell differentiation by CD80/CD86-CD28 costimulation and restoration by IL-2 during the recall response. J Immunol 180(2):1148-57. [PubMed: 18178855]  [MGI Ref ID J:130942]

Garcia CA; Martin M; Michalek SM. 2004. Role of B7 costimulatory molecules in mediating systemic and mucosal antibody responses to attenuated Salmonella enterica serovar Typhimurium and its cloned antigen. Infect Immun 72(10):5824-31. [PubMed: 15385483]  [MGI Ref ID J:93124]

Greenwald RJ; Oosterwegel MA; van Der Woude D; Kubal A; Mandelbrot DA; Boussiotis VA; Sharpe AH. 2002. CTLA-4 regulates cell cycle progression during a primary immune response. Eur J Immunol 32(2):366-73. [PubMed: 11807776]  [MGI Ref ID J:74753]

Hagen KA; Moses CT; Drasler EF; Podetz-Pedersen KM; Jameson SC; Khoruts A. 2004. A role for CD28 in lymphopenia-induced proliferation of CD4 T cells. J Immunol 173(6):3909-15. [PubMed: 15356139]  [MGI Ref ID J:92743]

Hao S; Yuan J; Xiang J. 2007. Nonspecific CD4+ T cells with uptake of antigen-specific dendritic cell-released exosomes stimulate antigen-specific CD8+ CTL responses and long-term T cell memory. J Leukoc Biol 82(4):829-38. [PubMed: 17626150]  [MGI Ref ID J:125204]

Hernandez HJ; Sharpe AH; Stadecker MJ. 1999. Experimental murine schistosomiasis in the absence of B7 costimulatory molecules: reversal of elicited T cell cytokine profile and partial inhibition of egg granuloma formation. J Immunol 162(5):2884-9. [PubMed: 10072537]  [MGI Ref ID J:53749]

Hosiawa KA; Wang H; DeVries ME; Garcia B; Liu W; Zhou D; Akram A; Jiang J; Sun H; Cameron MJ; Zhong R; Kelvin DJ. 2005. CD80/CD86 costimulation regulates acute vascular rejection. J Immunol 175(9):6197-204. [PubMed: 16237117]  [MGI Ref ID J:119363]

Jabs C; Greve B; Chang TT; Sobel RA; Sharpe AH; Kuchroo VK. 2002. Genetic background determines the requirement for B7 costimulation in induction of autoimmunity. Eur J Immunol 32(9):2687-97. [PubMed: 12207354]  [MGI Ref ID J:78992]

Krupnick AS; Gelman AE; Barchet W; Richardson S; Kreisel FH; Turka LA; Colonna M; Patterson GA; Kreisel D. 2005. Murine vascular endothelium activates and induces the generation of allogeneic CD4+25+Foxp3+ regulatory T cells. J Immunol 175(10):6265-70. [PubMed: 16272276]  [MGI Ref ID J:119348]

Liang B; Gee RJ; Kashgarian MJ; Sharpe AH; Mamula MJ. 1999. B7 costimulation in the development of lupus: autoimmunity arises either in the absence of B7.1/B7.2 or in the presence of anti-b7.1/B7.2 blocking antibodies. J Immunol 163(4):2322-9. [PubMed: 10438978]  [MGI Ref ID J:118772]

Liang B; Kashgarian MJ; Sharpe AH; Mamula MJ. 2000. Autoantibody responses and pathology regulated by B7-1 and B7-2 costimulation in MRL/lpr lupus J Immunol 165(6):3436-43. [PubMed: 10975864]  [MGI Ref ID J:64568]

Litzinger MT; Su Y; Lei TC; Soukhareva N; Scott DW. 2005. Mechanisms of gene therapy for tolerance: B7 signaling is required for peptide-IgG gene-transferred tolerance induction. J Immunol 175(2):780-7. [PubMed: 16002674]  [MGI Ref ID J:100709]

Loser K; Scherer A; Krummen MB; Varga G; Higuchi T; Schwarz T; Sharpe AH; Grabbe S; Bluestone JA; Beissert S. 2005. An important role of CD80/CD86-CTLA-4 signaling during photocarcinogenesis in mice. J Immunol 174(9):5298-305. [PubMed: 15843526]  [MGI Ref ID J:98420]

Mandelbrot DA; Furukawa Y; McAdam AJ; Alexander SI; Libby P; Mitchell RN; Sharpe AH. 1999. Expression of B7 molecules in recipient, not donor, mice determines the survival of cardiac allografts. J Immunol 163(7):3753-7. [PubMed: 10490971]  [MGI Ref ID J:110831]

Mandelbrot DA; Oosterwegel MA; Shimizu K; Yamada A; Freeman GJ; Mitchell RN; Sayegh MH; Sharpe AH. 2001. B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4. J Clin Invest 107(7):881-7. [PubMed: 11285307]  [MGI Ref ID J:68642]

Mark DA; Donovan CE; De Sanctis GT; He HZ; Cernadas M; Kobzik L; Perkins DL; Sharpe A; Finn PW. 2000. B7-1 (CD80) and B7-2 (CD86) have complementary roles in mediating allergic pulmonary inflammation and airway hyperresponsiveness. Am J Respir Cell Mol Biol 22(3):265-71. [PubMed: 10696062]  [MGI Ref ID J:114244]

Matlack R; Yeh K; Rosini L; Gonzalez D; Taylor J; Silberman D; Pennello A; Riggs J. 2006. Peritoneal macrophages suppress T-cell activation by amino acid catabolism. Immunology 117(3):386-95. [PubMed: 16476058]  [MGI Ref ID J:107076]

McAdam AJ; Farkash EA; Gewurz BE; Sharpe AH. 2000. B7 costimulation is critical for antibody class switching and CD8(+) cytotoxic T-lymphocyte generation in the host response to vesicular stomatitis virus. J Virol 74(1):203-8. [PubMed: 10590107]  [MGI Ref ID J:125985]

Mencacci A; Montagnoli C; Bacci A; Cenci E; Pitzurra L; Spreca A; Kopf M; Sharpe AH; Romani L. 2002. CD80+Gr-1+ myeloid cells inhibit development of antifungal Th1 immunity in mice with candidiasis. J Immunol 169(6):3180-90. [PubMed: 12218136]  [MGI Ref ID J:120204]

Mizoguchi E; Mizoguchi A; Preffer FI; Bhan AK. 2000. Regulatory role of mature B cells in a murine model of inflammatory bowel disease. Int Immunol 12(5):597-605. [PubMed: 10784605]  [MGI Ref ID J:110524]

Montagnoli C; Bacci A; Bozza S; Gaziano R; Mosci P; Sharpe AH; Romani L. 2002. B7/CD28-dependent CD4+CD25+ regulatory T cells are essential components of the memory-protective immunity to Candida albicans. J Immunol 169(11):6298-308. [PubMed: 12444136]  [MGI Ref ID J:118777]

Montagnoli C; Fallarino F; Gaziano R; Bozza S; Bellocchio S; Zelante T; Kurup WP; Pitzurra L; Puccetti P; Romani L. 2006. Immunity and tolerance to Aspergillus involve functionally distinct regulatory T cells and tryptophan catabolism. J Immunol 176(3):1712-23. [PubMed: 16424201]  [MGI Ref ID J:126452]

Nierkens S; Aalbers M; Bol M; Bleumink R; van Kooten P; Boon L; Pieters R. 2005. Differential requirement for CD28/CTLA-4-CD80/CD86 interactions in drug-induced type 1 and type 2 immune responses to trinitrophenyl-ovalbumin. J Immunol 175(6):3707-14. [PubMed: 16148116]  [MGI Ref ID J:116718]

Nurieva R; Thomas S; Nguyen T; Martin-Orozco N; Wang Y; Kaja MK; Yu XZ; Dong C. 2006. T-cell tolerance or function is determined by combinatorial costimulatory signals. EMBO J 25(11):2623-33. [PubMed: 16724117]  [MGI Ref ID J:109521]

Odobasic D; Kitching AR; Tipping PG; Holdsworth SR. 2005. CD80 and CD86 costimulatory molecules regulate crescentic glomerulonephritis by different mechanisms. Kidney Int 68(2):584-94. [PubMed: 16014035]  [MGI Ref ID J:114308]

Oosterwegel MA; Mandelbrot DA; Boyd SD; Lorsbach RB; Jarrett DY; Abbas AK; Sharpe AH. 1999. The role of CTLA-4 in regulating Th2 differentiation. J Immunol 163(5):2634-9. [PubMed: 10453003]  [MGI Ref ID J:57090]

Perez N; Karumuthil-Melethil S; Li R; Prabhakar BS; Holterman MJ; Vasu C. 2008. Preferential costimulation by CD80 results in IL-10-dependent TGF-beta1(+) -adaptive regulatory T cell generation. J Immunol 180(10):6566-76. [PubMed: 18453575]  [MGI Ref ID J:134959]

Poussin MA; Tuzun E; Goluszko E; Scott BG; Yang H; Franco JU; Christadoss P. 2003. B7-1 costimulatory molecule is critical for the development of experimental autoimmune myasthenia gravis. J Immunol 170(8):4389-96. [PubMed: 12682276]  [MGI Ref ID J:125435]

Sabzevari H; Kantor J; Jaigirdar A; Tagaya Y; Naramura M; Hodge J; Bernon J; Schlom J. 2001. Acquisition of CD80 (B7-1) by T cells. J Immunol 166(4):2505-13. [PubMed: 11160311]  [MGI Ref ID J:126137]

Salomon B; Lenschow DJ; Rhee L; Ashourian N; Singh B; Sharpe A; Bluestone JA. 2000. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity 12(4):431-40. [PubMed: 10795741]  [MGI Ref ID J:61905]

Schneider H; Mandelbrot DA; Greenwald RJ; Ng F; Lechler R; Sharpe AH; Rudd CE. 2002. Cutting edge: CTLA-4 (CD152) differentially regulates mitogen-activated protein kinases (extracellular signal-regulated kinase and c-Jun N-terminal kinase) in CD4+ T cells from receptor/ligand-deficient mice. J Immunol 169(7):3475-9. [PubMed: 12244135]  [MGI Ref ID J:120409]

Schweitzer AN; Sharpe AH. 1998. Studies using antigen-presenting cells lacking expression of both B7-1 (CD80) and B7-2 (CD86) show distinct requirements for B7 molecules during priming versus restimulation of Th2 but not Th1 cytokine production. J Immunol 161(6):2762-71. [PubMed: 9743334]  [MGI Ref ID J:64294]

Shi M; Ye Z; Umeshappa KS; Moyana T; Xiang J. 2007. Alpha tumor necrosis factor contributes to CD8(+) T cell survival in the transition phase. Biochem Biophys Res Commun 360(3):702-7. [PubMed: 17618911]  [MGI Ref ID J:123025]

Shi Z; Rifa'i M; Lee YH; Shiku H; Isobe K; Suzuki H. 2008. Importance of CD80/CD86-CD28 interactions in the recognition of target cells by CD8+CD122+ regulatory T cells. Immunology 124(1):121-8. [PubMed: 18205792]  [MGI Ref ID J:136528]

Shin T; Kennedy G; Gorski K; Tsuchiya H; Koseki H; Azuma M; Yagita H; Chen L; Powell J; Pardoll D; Housseau F. 2003. Cooperative B7-1/2 (CD80/CD86) and B7-DC Costimulation of CD4+ T Cells Independent of the PD-1 Receptor. J Exp Med 198(1):31-8. [PubMed: 12847135]  [MGI Ref ID J:84457]

Strainic MG; Liu J; Huang D; An F; Lalli PN; Muqim N; Shapiro VS; Dubyak GR; Heeger PS; Medof ME. 2008. Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells. Immunity 28(3):425-35. [PubMed: 18328742]  [MGI Ref ID J:132942]

Sugita S; Keino H; Futagami Y; Takase H; Mochizuki M; Stein-Streilein J; Streilein JW. 2006. B7+ iris pigment epithelial cells convert T cells into CTLA-4+, B7-expressing CD8+ regulatory T cells. Invest Ophthalmol Vis Sci 47(12):5376-84. [PubMed: 17122127]  [MGI Ref ID J:123098]

Sugita S; Ng TF; Schwartzkopff J; Streilein JW. 2004. CTLA-4+CD8+ T cells that encounter B7-2+ iris pigment epithelial cells express their own B7-2 to achieve global suppression of T cell activation. J Immunol 172(7):4184-94. [PubMed: 15034031]  [MGI Ref ID J:88713]

Sugita S; Streilein JW. 2003. Iris pigment epithelium expressing CD86 (B7-2) directly suppresses T cell activation in vitro via binding to cytotoxic T lymphocyte-associated antigen 4. J Exp Med 198(1):161-71. [PubMed: 12835481]  [MGI Ref ID J:84466]

Vacchio MS; Williams JA; Hodes RJ. 2005. A novel role for CD28 in thymic selection: elimination of CD28/B7 interactions increases positive selection. Eur J Immunol 35(2):418-27. [PubMed: 15657954]  [MGI Ref ID J:95546]

Williams JA; Lumsden JM; Yu X; Feigenbaum L; Zhang J; Steinberg SM; Hodes RJ. 2008. Regulation of thymic NKT cell development by the B7-CD28 costimulatory pathway. J Immunol 181(2):907-17. [PubMed: 18606642]  [MGI Ref ID J:137437]

Williams JA; Sharrow SO; Adams AJ; Hodes RJ. 2002. CD40 ligand functions non-cell autonomously to promote deletion of self-reactive thymocytes. J Immunol 168(6):2759-65. [PubMed: 11884443]  [MGI Ref ID J:126679]

Yadav D; Fine C; Azuma M; Sarvetnick N. 2007. B7-1 mediated costimulation regulates pancreatic autoimmunity. Mol Immunol 44(10):2616-24. [PubMed: 17289146]  [MGI Ref ID J:118681]

Yang R; Cai Z; Zhang Y; Yutzy WH th; Roby KF; Roden RB. 2006. CD80 in immune suppression by mouse ovarian carcinoma-associated Gr-1+CD11b+ myeloid cells. Cancer Res 66(13):6807-15. [PubMed: 16818658]  [MGI Ref ID J:110568]

Yu X; Fournier S; Allison JP; Sharpe AH; Hodes RJ. 2000. The role of B7 costimulation in CD4/CD8 T cell homeostasis. J Immunol 164(7):3543-53. [PubMed: 10725709]  [MGI Ref ID J:112266]

Zhang P; Martin M; Yang QB; Michalek SM; Katz J. 2004. Role of B7 costimulatory molecules in immune responses and T-helper cell differentiation in response to recombinant HagB from Porphyromonas gingivalis. Infect Immun 72(2):637-44. [PubMed: 14742503]  [MGI Ref ID J:87827]

Zheng X; Zhang H; Yin L; Wang CR; Liu Y; Zheng P. 2008. Modulation of NKT cell development by B7-CD28 interaction: an expanding horizon for costimulation. PLoS ONE 3(7):e2703. [PubMed: 18628995]  [MGI Ref ID J:139280]

Zheng XX; Sayegh MH; Zheng XG; Li Y; Linsley PS; Peach R; Borriello F ; Strom TB ; Sharpe AH ; Turka LA. 1997. The role of donor and recipient B7-1 (CD80) in allograft rejection. J Immunol 159(3):1169-73. [PubMed: 9233610]  [MGI Ref ID J:41643]

Rag1tm1Mom related
Ait-Azzouzene D; Verkoczy L; Peters J; Gavin A; Skog P; Vela JL; Nemazee D. 2005. An immunoglobulin C{kappa}-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system. J Exp Med 201(5):817-28. [PubMed: 15738053]  [MGI Ref ID J:96759]

Alugupalli KR; Gerstein RM; Chen J; Szomolanyi-Tsuda E; Woodland RT; Leong JM. 2003. The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes. J Immunol 170(7):3819-27. [PubMed: 12646649]  [MGI Ref ID J:125443]

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Anderson MG; Nair KS; Amonoo LA; Mehalow A; Trantow CM; Masli S; John SW. 2008. GpnmbR150X allele must be present in bone marrow derived cells to mediate DBA/2J glaucoma. BMC Genet 9:30. [PubMed: 18402690]  [MGI Ref ID J:134670]

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