Description

Strain Information

Former Names B6(129P2) Nos2tm1Lau-chtl/J    (Changed: 22-JUN-09 ) B6(129P2) Nos2tm1Lau-chtl/J    (Changed: 11-MAY-05 ) Type Coisogenic; Congenic; Mutant Strain; Spontaneous Mutation; Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Homozygote x Homozygote         (Female x Male)   01-MAR-06 Species laboratory mouse Generation N7+F4+F41 (05-NOV-09)

Appearance
dark brown
Related Genotype: a/a chtl/chtl

Important Note
This strain is homozygous for Nos2^tm1Lau.

Description
This mutant has an overall lighter coat, tail and ears than a black +/+ control. Both males and females breed and it is maintained as a homozygous stock.

Development
This mutation was discovered at The Jackson Laboratory in 1998 in the C57BL/6J-Nos2^tm1Lau/J (Stock # 002609) strain at generation N7F4+F16.

Control Information

	Control
	002609 B6.129P2-Nos2tm1Lau/J
	000664 C57BL/6J
		Because chtl arose on B6.129P2-Nos2tm1Lau/J (Stock # 002609) and this chtl-bearing subline remains homozygous for the targeted mutation, B6.129P2-Nos2tm1Lau/J (Stock # 002609) is the best available control for this strain.
Considerations for Choosing Controls

Related Strains

Strains carrying   Nos2^tm1Lau allele

002609	B6.129P2-Nos2tm1Lau/J
009126	B6.Cg-Nos2tm1Lau Tg(Thy1-APPSwDutIowa)BWevn/J
002596	B6;129P2-Nos2tm1Lau/J
007072	CByJ.129P2(B6)-Nos2tm1Lau/J

View Strains carrying   Nos2^tm1Lau     (4 strains)

Strains carrying other alleles of chtl

005565

B6(V)-chtl2J/GrsrJ

View Strains carrying other alleles of chtl     (1 strain)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms

      assigned by genotype

chtl/chtl

        B6.129P2-Nos2^tm1Lau/J

• pigmentation phenotype
• diluted coat color (MGI Ref ID J:82799)
  • overall lighter coat, tail, and ears than black a/a controls
  • matings with homozygous chocolate (cht/cht) mice did not produce the expected chocolate colored mice, but instead produced progeny with a dull grey phenotype
• skin/coat/nails phenotype
• diluted coat color (MGI Ref ID J:82799)
  • overall lighter coat, tail, and ears than black a/a controls
  • matings with homozygous chocolate (cht/cht) mice did not produce the expected chocolate colored mice, but instead produced progeny with a dull grey phenotype

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Neurobiology Research
Parkinson's Disease
      resistance to MPTP

Nos2^tm1Lau related

Immunology and Inflammation Research
Inflammation
      Inflammatory bowel disease

Neurobiology Research
Alzheimer's Disease

chtl related

Dermatology Research
Color and White Spotting Defects

Genes & Alleles

Gene & Allele Information

Allele Symbol		Nos2tm1Lau
Allele Name		targeted mutation 1, Victor E Laubach
Allele Type		Targeted (knock-out)
Common Name(s)		NOS2-; NOS2tm/Lau; Nos2tm1Lau; iNOS KO; iNOS-;
Mutation Made By		Victor Laubach,   University of Virginia Health Sci. Ctr.
Strain of Origin		129P2/OlaHsd
ES Cell Line Name		E14TG2a
ES Cell Line Strain		129P2/OlaHsd
Gene Symbol and Name		Nos2, nitric oxide synthase 2, inducible
Chromosome		11
Gene Common Name(s)		HEP-NOS; INOS; NOS; NOS-II; NOS2A; Nos-2; nitric oxide synthase-2 (brain);
Molecular Note		A neomycin cassette replaced exons 12 and 13 of the gene, which encode the calmodulin-binding domain. Northern and Western blots of IFNg/LPS-stimulated peritoneal macrophages showed no detectable Nos2 mRNA or protein, respectively. [MGI Ref ID J:29677]
Allele Symbol		chtl
Allele Name		chocolate-like
Allele Type		Spontaneous
Strain of Origin		B6.129P2-Nos2tm1Lau/J
Gene Symbol and Name		chtl, chocolate-like
Chromosome		7
General Note		A test for allelism with homozygous cht mouse mated to a homozygous mutant mouse produced 32/32 progeny with a dull grey phenotype, unlike cht or a/a . These results suggested chtl is a new allele of the cht gene that produces a different phenotype fromthe original cht allele. When two matings of the grey color F1s from the allele test progeny were mated together, however, they produced segregating litters for a total of 10 cht looking mice and 3 normal black a/a mice. The appearance of the black mice means either the two mutations are pseudoalleles or modiefier genes can affect the phenotype expresssion.
Molecular Note		The chocolate-like spontaneous mutation was found at The Jackson Laboratory in 1998. A test for allelism to the cht locus demonstrated that the two mutations are in pseudoalleles or that modifier genes in the two background strains can affect the phenotype expression.

Genotyping

Genotyping Information

Genotyping Protocols

Nos2^tm1Lau, Standard PCR

Helpful Links

Genotyping resources and troubleshooting

References

References

Selected Reference(s)

Ward-Bailey PF; Harris B; Bronson R; Johnson K; Davisson M. 2003. Chocolate-like, a spontaneous mutation causing a dark brown coat color in the mouse. Mouse Mutant Resources Web Site, The Jackson Laboratory, Bar Harbor, Maine (http://www.jax.org/mmr) MGI Direct Data Submission :.  [MGI Ref ID J:82799]

Additional References

Nos2^tm1Lau related

Abu-Ghanem Y; Cohen H; Buskila Y; Grauer E; Amitai Y. 2008. Enhanced stress reactivity in nitric oxide synthase type 2 mutant mice: findings in support of astrocytic nitrosative modulation of behavior. Neuroscience 156(2):257-65. [PubMed: 18723080]  [MGI Ref ID J:141014]

Adams LB; Job CK; Krahenbuhl JL. 2000. Role of inducible nitric oxide synthase in resistance to Mycobacterium leprae in mice. Infect Immun 68(9):5462-5. [PubMed: 10948185]  [MGI Ref ID J:64036]

Ahn B; Ohshima H. 2001. Suppression of intestinal polyposis in Apc(Min/+) mice by inhibiting nitric oxide production. Cancer Res 61(23):8357-60. [PubMed: 11731407]  [MGI Ref ID J:73152]

Akita Y; Otani H; Matsuhisa S; Kyoi S; Enoki C; Hattori R; Imamura H; Kamihata H; Kimura Y; Iwasaka T. 2007. Exercise-induced activation of cardiac sympathetic nerve triggers cardioprotection via redox-sensitive activation of eNOS and upregulation of iNOS. Am J Physiol Heart Circ Physiol 292(5):H2051-9. [PubMed: 17259438]  [MGI Ref ID J:125942]

Anand RJ; Dai S; Rippel C; Leaphart C; Qureshi F; Gribar SC; Kohler JW; Li J; Stolz DB; Sodhi C; Hackam DJ. 2008. Activated macrophages inhibit enterocyte gap junctions via the release of nitric oxide. Am J Physiol Gastrointest Liver Physiol 294(1):G109-19. [PubMed: 17975131]  [MGI Ref ID J:130509]

Ando A; Yang A; Mori K; Yamada H; Yamada E; Takahashi K; Saikia J; Kim M; Melia M; Fishman M; Huang P; Campochiaro PA. 2002. Nitric oxide is proangiogenic in the retina and choroid. J Cell Physiol 191(1):116-24. [PubMed: 11920687]  [MGI Ref ID J:106207]

Andrade RM; Portillo JA; Wessendarp M; Subauste CS. 2005. CD40 signaling in macrophages induces activity against an intracellular pathogen independently of gamma interferon and reactive nitrogen intermediates. Infect Immun 73(5):3115-23. [PubMed: 15845519]  [MGI Ref ID J:97614]

Arantes RM; Marche HH; Bahia MT; Cunha FQ; Rossi MA; Silva JS. 2004. Interferon-gamma-induced nitric oxide causes intrinsic intestinal denervation in Trypanosoma cruzi-infected mice. Am J Pathol 164(4):1361-8. [PubMed: 15039223]  [MGI Ref ID J:89108]

Arnett HA; Hellendall RP; Matsushima GK; Suzuki K; Laubach VE; Sherman P; Ting JP. 2002. The protective role of nitric oxide in a neurotoxicant-induced demyelinating model. J Immunol 168(1):427-33. [PubMed: 11751989]  [MGI Ref ID J:125459]

Bartholdy C; Nansen A; Christensen JE; Marker O; Thomsen AR. 1999. Inducible nitric-oxide synthase plays a minimal role in lymphocytic choriomeningitis virus-induced, T cell-mediated protective immunity and immunopathology. J Gen Virol 80(Pt 11):2997-3005. [PubMed: 10580062]  [MGI Ref ID J:103345]

Beck PL; Li Y; Wong J; Chen CW; Keenan CM; Sharkey KA; McCafferty DM. 2007. Inducible nitric oxide synthase from bone marrow-derived cells plays a critical role in regulating colonic inflammation. Gastroenterology 132(5):1778-90. [PubMed: 17449036]  [MGI Ref ID J:128325]

Beck PL; Xavier R; Wong J; Ezedi I; Mashimo H; Mizoguchi A; Mizoguchi E; Bhan AK; Podolsky DK. 2004. Paradoxical roles of different nitric oxide synthase isoforms in colonic injury. Am J Physiol Gastrointest Liver Physiol 286(1):G137-47. [PubMed: 14665440]  [MGI Ref ID J:87601]

Blanchard TG; Yu F; Hsieh CL; Redline RW. 2003. Severe inflammation and reduced bacteria load in murine helicobacter infection caused by lack of phagocyte oxidase activity. J Infect Dis 187(10):1609-15. [PubMed: 12721941]  [MGI Ref ID J:120653]

Bokhari SM; Kim KJ; Pinson DM; Slusser J; Yeh HW; Parmely MJ. 2008. NK cells and gamma interferon coordinate the formation and function of hepatic granulomas in mice infected with the Francisella tularensis live vaccine strain. Infect Immun 76(4):1379-89. [PubMed: 18227174]  [MGI Ref ID J:133531]

Brahmachari S; Pahan K. 2009. Suppression of regulatory T cells by IL-12p40 homodimer via nitric oxide. J Immunol 183(3):2045-58. [PubMed: 19587012]  [MGI Ref ID J:151706]

Bratt JM; Franzi LM; Linderholm AL; Last MS; Kenyon NJ; Last JA. 2009. Arginase enzymes in isolated airways from normal and nitric oxide synthase 2-knockout mice exposed to ovalbumin. Toxicol Appl Pharmacol 234(3):273-80. [PubMed: 19027033]  [MGI Ref ID J:145875]

Breitbach K; Klocke S; Tschernig T; van Rooijen N; Baumann U; Steinmetz I. 2006. Role of Inducible Nitric Oxide Synthase and NADPH Oxidase in Early Control of Burkholderia pseudomallei Infection in Mice. Infect Immun 74(11):6300-6309. [PubMed: 17000727]  [MGI Ref ID J:113561]

Buhtoiarov IN; Lum HD; Berke G; Sondel PM; Rakhmilevich AL. 2006. Synergistic activation of macrophages via CD40 and TLR9 results in T cell independent antitumor effects. J Immunol 176(1):309-18. [PubMed: 16365423]  [MGI Ref ID J:126263]

Burrer R; Buchmeier MJ; Wolfe T; Ting JP; Feuer R; Iglesias A; von Herrath MG. 2007. Exacerbated pathology of viral encephalitis in mice with central nervous system-specific autoantibodies. Am J Pathol 170(2):557-66. [PubMed: 17255324]  [MGI Ref ID J:117906]

Buskila Y; Abu-Ghanem Y; Levi Y; Moran A; Grauer E; Amitai Y. 2007. Enhanced astrocytic nitric oxide production and neuronal modifications in the neocortex of a NOS2 mutant mouse. PLoS ONE 2(9):e843. [PubMed: 17786214]  [MGI Ref ID J:129384]

Buxbaum LU; Uzonna JE; Goldschmidt MH; Scott P. 2002. Control of New World cutaneous leishmaniasis is IL-12 independent but STAT4 dependent. Eur J Immunol 32(11):3206-15. [PubMed: 12555666]  [MGI Ref ID J:115538]

Cambien B; Bergmeier W; Saffaripour S; Mitchell HA; Wagner DD. 2003. Antithrombotic activity of TNF-alpha. J Clin Invest 112(10):1589-96. [PubMed: 14617760]  [MGI Ref ID J:117987]

Carnio EC; Stabile AM; Batalhao ME; Silva JS; Antunes-Rodrigues J; Branco LG; Magder S. 2005. Vasopressin release during endotoxaemic shock in mice lacking inducible nitric oxide synthase. Pflugers Arch 450(6):390-4. [PubMed: 15971084]  [MGI Ref ID J:106197]

Cauwels A; Janssen B; Buys E; Sips P; Brouckaert P. 2006. Anaphylactic shock depends on PI3K and eNOS-derived NO. J Clin Invest 116(8):2244-51. [PubMed: 16886062]  [MGI Ref ID J:113106]

Cauwels A; Van Molle W; Janssen B; Everaerdt B; Huang P; Fiers W; Brouckaert P. 2000. Protection against TNF-induced lethal shock by soluble guanylate cyclase inhibition requires functional inducible nitric oxide synthase. Immunity 13(2):223-31. [PubMed: 10981965]  [MGI Ref ID J:64176]

Chatterjee S; Lardinois O; Bonini MG; Bhattacharjee S; Stadler K; Corbett J; Deterding LJ; Tomer KB; Kadiiska M; Mason RP. 2009. Site-specific carboxypeptidase B1 tyrosine nitration and pathophysiological implications following its physical association with nitric oxide synthase-3 in experimental sepsis. J Immunol 183(6):4055-66. [PubMed: 19717511]  [MGI Ref ID J:152293]

Chauhan SD; Seggara G; Vo PA; Macallister RJ; Hobbs AJ; Ahluwalia A. 2003. Protection against lipopolysaccharide-induced endothelial dysfunction in resistance and conduit vasculature of iNOS knockout mice. FASEB J 17(6):773-5. [PubMed: 12586741]  [MGI Ref ID J:118016]

Chen L; Majde JA; Krueger JM. 2003. Spontaneous sleep in mice with targeted disruptions of neuronal or inducible nitric oxide synthase genes. Brain Res 973(2):214-22. [PubMed: 12738065]  [MGI Ref ID J:83571]

Chen L; Taishi P; Duricka D; Krueger JM. 2004. Brainstem prolactin mRNA is enhanced in mice with suppressed neuronal nitric oxide synthase activity. Brain Res Mol Brain Res 129(1-2):179-84. [PubMed: 15469894]  [MGI Ref ID J:115454]

Chen L; Taishi P; Majde JA; Peterfi Z; Obal F Jr; Krueger JM. 2004. The role of nitric oxide synthases in the sleep responses to tumor necrosis factor-alpha. Brain Behav Immun 18(4):390-8. [PubMed: 15157956]  [MGI Ref ID J:105452]

Choi KS; Song EK; Yim CY. 2008. Cytokines secreted by IL-2-activated lymphocytes induce endogenous nitric oxide synthesis and apoptosis in macrophages. J Leukoc Biol 83(6):1440-50. [PubMed: 18339892]  [MGI Ref ID J:136847]

Chyu KY; Dimayuga P; Zhu J; Nilsson J; Kaul S; Shah PK; Cercek B. 1999. Decreased neointimal thickening after arterial wall injury in inducible nitric oxide synthase knockout mice. Circ Res 85(12):1192-8. [PubMed: 10590247]  [MGI Ref ID J:59834]

Cole MP; Chaiswing L; Oberley TD; Edelmann SE; Piascik MT; Lin SM; Kiningham KK; St Clair DK. 2006. The protective roles of nitric oxide and superoxide dismutase in adriamycin-induced cardiotoxicity. Cardiovasc Res 69(1):186-97. [PubMed: 16157314]  [MGI Ref ID J:133742]

Collazo CM; Meierovics AI; De Pascalis R; Wu TH; Lyons CR; Elkins KL. 2009. T cells from lungs and livers of Francisella tularensis-immune mice control the growth of intracellular bacteria. Infect Immun 77(5):2010-21. [PubMed: 19237526]  [MGI Ref ID J:148524]

Colton CA; Vitek MP; Wink DA; Xu Q; Cantillana V; Previti ML; Van Nostrand WE; Weinberg B; Dawson H. 2006. NO synthase 2 (NOS2) deletion promotes multiple pathologies in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A 103(34):12867-72. [PubMed: 16908860]  [MGI Ref ID J:112919]

Colton CA; Wilcock DM; Wink DA; Davis J; Van Nostrand WE; Vitek MP. 2008. The effects of NOS2 gene deletion on mice expressing mutated human AbetaPP. J Alzheimers Dis 15(4):571-87. [PubMed: 19096157]  [MGI Ref ID J:143551]

Comtois AS; El-Dwairi Q; Laubach VE; Hussain SN. 1999. Lipopolysaccharide-induced diaphragmatic contractile dysfunction in mice lacking the inducible nitric oxide synthase. Am J Respir Crit Care Med 159(6):1975-80. [PubMed: 10351947]  [MGI Ref ID J:57227]

Cowley SC; Hamilton E; Frelinger JA; Su J; Forman J; Elkins KL. 2005. CD4-CD8- T cells control intracellular bacterial infections both in vitro and in vivo. J Exp Med 202(2):309-19. [PubMed: 16027239]  [MGI Ref ID J:100513]

Cuenca J; Martin-Sanz P; Alvarez-Barrientos AM; Bosca L; Goren N. 2006. Infiltration of Inflammatory Cells Plays an Important Role in Matrix Metalloproteinase Expression and Activation in the Heart during Sepsis. Am J Pathol 169(5):1567-76. [PubMed: 17071581]  [MGI Ref ID J:114564]

Dal Secco D; Paron JA; de Oliveira SH; Ferreira SH; Silva JS; Cunha Fde Q. 2003. Neutrophil migration in inflammation: nitric oxide inhibits rolling, adhesion and induces apoptosis. Nitric Oxide 9(3):153-64. [PubMed: 14732339]  [MGI Ref ID J:118999]

Dallaire P; Bellmann K; Laplante M; Gelinas S; Centeno-Baez C; Penfornis P; Peyot ML; Latour MG; Lamontagne J; Trujillo ME; Scherer PE; Prentki M; Deshaies Y; Marette A. 2008. Obese mice lacking inducible nitric oxide synthase are sensitized to the metabolic actions of peroxisome proliferator-activated receptor-gamma agonism. Diabetes 57(8):1999-2011. [PubMed: 18458147]  [MGI Ref ID J:141699]

Davie SA; Maglione JE; Manner CK; Young D; Cardiff RD; MacLeod CL; Ellies LG. 2007. Effects of FVB/NJ and C57Bl/6J strain backgrounds on mammary tumor phenotype in inducible nitric oxide synthase deficient mice. Transgenic Res 16(2):193-201. [PubMed: 17206489]  [MGI Ref ID J:121391]

De Luca G; Di Giorgio RM; Macaione S; Calpona PR; Di Paola ED; Costa N; Cuzzocrea S; Citraro R; Russo E; De Sarro G. 2006. Amino acid levels in some brain areas of inducible nitric oxide synthase knock out mouse (iNOS-/-) before and after pentylenetetrazole kindling. Pharmacol Biochem Behav 85(4):804-12. [PubMed: 17223186]  [MGI Ref ID J:124504]

Demchenko IT; Atochin DN; Gutsaeva DR; Godfrey RR; Huang PL; Piantadosi CA; Allen BW. 2008. Contributions of nitric oxide synthase isoforms to pulmonary oxygen toxicity, local vs. mediated effects. Am J Physiol Lung Cell Mol Physiol 294(5):L984-90. [PubMed: 18326824]  [MGI Ref ID J:136632]

Denda A; Kitayama W; Kishida H; Murata N; Tamura K; Kusuoka O; Tsutsumi M; Nishikawa F; Kita E; Nakae D; Konishi Y; Kuniyasu H. 2007. Expression of inducible nitric oxide (NO) synthase but not prevention by its gene ablation of hepatocarcinogenesis with fibrosis caused by a choline-deficient, L-amino acid-defined diet in rats and mice. Nitric Oxide 16(1):164-76. [PubMed: 16931074]  [MGI Ref ID J:118071]

Di Marco S; Mazroui R; Dallaire P; Chittur S; Tenenbaum SA; Radzioch D; Marette A; Gallouzi IE. 2005. NF-(kappa)B-mediated MyoD decay during muscle wasting requires nitric oxide synthase mRNA stabilization, HuR protein, and nitric oxide release. Mol Cell Biol 25(15):6533-45. [PubMed: 16024790]  [MGI Ref ID J:100108]

DiMagno MJ; Hao Y; Tsunoda Y; Williams JA; Owyang C. 2004. Secretagogue-stimulated pancreatic secretion is differentially regulated by constitutive NOS isoforms in mice. Am J Physiol Gastrointest Liver Physiol 286(3):G428-36. [PubMed: 14551061]  [MGI Ref ID J:95674]

Dias MB; Almeida MC; Carnio EC; Branco LG. 2005. Role of nitric oxide in tolerance to lipopolysaccharide in mice. J Appl Physiol 98(4):1322-7. [PubMed: 15579566]  [MGI Ref ID J:110018]

Diesen DL; Hess DT; Stamler JS. 2008. Hypoxic vasodilation by red blood cells: evidence for an s-nitrosothiol-based signal. Circ Res 103(5):545-53. [PubMed: 18658051]  [MGI Ref ID J:152645]

Edelson BT; Unanue ER. 2002. MyD88-dependent but Toll-like receptor 2-independent innate immunity to Listeria: no role for either in macrophage listericidal activity. J Immunol 169(7):3869-75. [PubMed: 12244184]  [MGI Ref ID J:120406]

Ellies LG. 2003. PyV-mT-induced parotid gland hyperplasia as detected by altered lectin reactivity is not modulated by inducible nitric oxide deficiency. Arch Oral Biol 48(6):415-22. [PubMed: 12749913]  [MGI Ref ID J:84218]

Ellies LG; Fishman M; Hardison J; Kleeman J; Maglione JE; Manner CK; Cardiff RD; MacLeod CL. 2003. Mammary tumor latency is increased in mice lacking the inducible nitric oxide synthase. Int J Cancer 106(1):1-7. [PubMed: 12794750]  [MGI Ref ID J:84004]

Fabis MJ; Scott GS; Kean RB; Koprowski H; Hooper DC. 2007. Loss of blood-brain barrier integrity in the spinal cord is common to experimental allergic encephalomyelitis in knockout mouse models. Proc Natl Acad Sci U S A 104(13):5656-61. [PubMed: 17372191]  [MGI Ref ID J:120115]

Falcone S; Perrotta C; De Palma C; Pisconti A; Sciorati C; Capobianco A; Rovere-Querini P; Manfredi AA; Clementi E. 2004. Activation of acid sphingomyelinase and its inhibition by the nitric oxide/cyclic guanosine 3',5'-monophosphate pathway: key events in Escherichia coli-elicited apoptosis of dendritic cells. J Immunol 173(7):4452-63. [PubMed: 15383576]  [MGI Ref ID J:93735]

Feng HM; Walker DH. 2004. Mechanisms of immunity to Ehrlichia muris: a model of monocytotropic ehrlichiosis. Infect Immun 72(2):966-71. [PubMed: 14742542]  [MGI Ref ID J:87862]

Fernandes KS; Neto EH; Brito MM; Silva JS; Cunha FQ; Barja-Fidalgo C. 2008. Detrimental role of endogenous nitric oxide in host defence against Sporothrix schenckii. Immunology 123(4):469-79. [PubMed: 18194265]  [MGI Ref ID J:136580]

Fukumura D; Gohongi T; Kadambi A; Izumi Y; Ang J; Yun CO; Buerk DG; Huang PL; Jain RK. 2001. Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability. Proc Natl Acad Sci U S A 98(5):2604-9. [PubMed: 11226286]  [MGI Ref ID J:67870]

Ganley L; Babu S; Rajan TV. 2001. Course of Brugia malayi infection in C57BL/6J NOS2 +/+ and -/- mice. Exp Parasitol 98(1):35-43. [PubMed: 11426950]  [MGI Ref ID J:102684]

Ghosn EE; Russo M; Almeida SR. 2006. Nitric oxide-dependent killing of Cryptococcus neoformans by B-1-derived mononuclear phagocyte. J Leukoc Biol 80(1):36-44. [PubMed: 16670124]  [MGI Ref ID J:110472]

Gillman BM; Batchelder J; Flaherty P; Weidanz WP. 2004. Suppression of Plasmodium chabaudi parasitemia is independent of the action of reactive oxygen intermediates and/or nitric oxide. Infect Immun 72(11):6359-66. [PubMed: 15501765]  [MGI Ref ID J:93252]

Gobert AP; Cheng Y; Akhtar M; Mersey BD; Blumberg DR; Cross RK; Chaturvedi R; Drachenberg CB; Boucher JL; Hacker A; Casero RA Jr; Wilson KT. 2004. Protective role of arginase in a mouse model of colitis. J Immunol 173(3):2109-17. [PubMed: 15265947]  [MGI Ref ID J:92035]

Goldmann O; von Kockritz-Blickwede M; Holtje C; Chhatwal GS; Geffers R; Medina E. 2007. Transcriptome analysis of murine macrophages in response to infection with Streptococcus pyogenes reveals an unusual activation program. Infect Immun 75(8):4148-57. [PubMed: 17526748]  [MGI Ref ID J:123374]

Gomez-Ambrosi J; Becerril S; Oroz P; Zabalza S; Rodriguez A; Muruzabal FJ; Archanco M; Gil MJ; Burrell MA; Fruhbeck G. 2004. Reduced adipose tissue mass and hypoleptinemia in iNOS deficient mice: effect of LPS on plasma leptin and adiponectin concentrations. FEBS Lett 577(3):351-6. [PubMed: 15556608]  [MGI Ref ID J:94571]

Gonzalez C; Cuvellier S; Hue-Beauvais C; Levi-Strauss M. 2003. Genetic control of non obese diabetic mice susceptibility to high-dose streptozotocin-induced diabetes. Diabetologia 46(9):1291-5. [PubMed: 12879252]  [MGI Ref ID J:95957]

Gorbunov NV; Kiang JG. 2009. Up-regulation of autophagy in small intestine Paneth cells in response to total-body gamma-irradiation. J Pathol 219(2):242-52. [PubMed: 19681094]  [MGI Ref ID J:152797]

Gramaglia I; Sobolewski P; Meays D; Contreras R; Nolan JP; Frangos JA; Intaglietta M; van der Heyde HC. 2006. Low nitric oxide bioavailability contributes to the genesis of experimental cerebral malaria. Nat Med 12(12):1417-22. [PubMed: 17099710]  [MGI Ref ID J:129543]

Greenberg SS; Ouyang J; Zhao X; Parrish C; Nelson S; Giles TD. 1999. Effects of ethanol on neutrophil recruitment and lung host defense in nitric oxide synthase I and nitric oxide synthase II knockout mice. Alcohol Clin Exp Res 23(9):1435-45. [PubMed: 10512307]  [MGI Ref ID J:59745]

Guhring H; Gorig M; Ates M; Coste O; Zeilhofer HU; Pahl A; Rehse K; Brune K. 2000. Suppressed injury-induced rise in spinal prostaglandin E2 production and reduced early thermal hyperalgesia in iNOS-deficient mice. J Neurosci 20(17):6714-20. [PubMed: 10964977]  [MGI Ref ID J:64215]

Guo Y; Jones WK; Xuan YT; Tang XL; Bao W; Wu WJ; Han H; Laubach VE; Ping P; Yang Z; Qiu Y; Bolli R. 1999. The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene [see comments] Proc Natl Acad Sci U S A 96(20):11507-12. [PubMed: 10500207]  [MGI Ref ID J:57975]

Guthrie SM; Curtis LM; Mames RN; Simon GG; Grant MB; Scott EW. 2005. The nitric oxide pathway modulates hemangioblast activity of adult hematopoietic stem cells. Blood 105(5):1916-22. [PubMed: 15546953]  [MGI Ref ID J:98135]

Hamada T; Duarte S; Tsuchihashi S; Busuttil RW; Coito AJ. 2009. Inducible nitric oxide synthase deficiency impairs matrix metalloproteinase-9 activity and disrupts leukocyte migration in hepatic ischemia/reperfusion injury. Am J Pathol 174(6):2265-77. [PubMed: 19443702]  [MGI Ref ID J:148923]

Hampton TG; Amende I; Fong J; Laubach VE; Li J; Metais C; Simons M. 2000. Basic FGF reduces stunning via a NOS2-dependent pathway in coronary-perfused mouse hearts. Am J Physiol Heart Circ Physiol 279(1):H260-8. [PubMed: 10899065]  [MGI Ref ID J:107850]

Hardiman KM; Lindsey JR; Matalon S. 2001. Lack of amiloride-sensitive transport across alveolar and respiratory epithelium of iNOS(-/-) mice in vivo. Am J Physiol Lung Cell Mol Physiol 281(3):L722-31. [PubMed: 11504701]  [MGI Ref ID J:71505]

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Peng X; Abdulnour RE; Sammani S; Ma SF; Han EJ; Hasan EJ; Tuder R; Garcia JG; Hassoun PM. 2005. Inducible nitric oxide synthase contributes to ventilator-induced lung injury. Am J Respir Crit Care Med 172(4):470-9. [PubMed: 15937288]  [MGI Ref ID J:114335]

Perreault M; Marette A. 2001. Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle. Nat Med 7(10):1138-43. [PubMed: 11590438]  [MGI Ref ID J:72215]

Peshes-Yaloz N; Rosen D; Sondel PM; Krammer PH; Berke G. 2007. Up-regulation of Fas (CD95) expression in tumour cells in vivo. Immunology 120(4):502-11. [PubMed: 17343612]  [MGI Ref ID J:122702]

Pol O; Sasaki M; Jimenez N; Dawson VL; Dawson TM; Puig MM. 2005. The involvement of nitric oxide in the enhanced expression of mu-opioid receptors during intestinal inflammation in mice. Br J Pharmacol 145(6):758-66. [PubMed: 15852037]  [MGI Ref ID J:114344]

Poljakovic M; Persson K. 2003. Urinary tract infection in iNOS-deficient mice with focus on bacterial sensitivity to nitric oxide. Am J Physiol Renal Physiol 284(1):F22-31. [PubMed: 12494944]  [MGI Ref ID J:127929]

Ponnuswamy P; Ostermeier E; Schrottle A; Chen J; Huang PL; Ertl G; Nieswandt B; Kuhlencordt PJ. 2009. Oxidative stress and compartment of gene expression determine proatherosclerotic effects of inducible nitric oxide synthase. Am J Pathol 174(6):2400-10. [PubMed: 19465644]  [MGI Ref ID J:148912]

Predescu D; Predescu S; Shimizu J; Miyawaki-Shimizu K; Malik AB. 2005. Constitutive eNOS-derived nitric oxide is a determinant of endothelial junctional integrity. Am J Physiol Lung Cell Mol Physiol 289(3):L371-81. [PubMed: 16093363]  [MGI Ref ID J:115733]

Qiu H; Kuolee R; Harris G; Chen W. 2009. Role of NADPH phagocyte oxidase in host defense against acute respiratory Acinetobacter baumannii infection in mice. Infect Immun 77(3):1015-21. [PubMed: 19103777]  [MGI Ref ID J:145717]

Ren G; Su J; Zhao X; Zhang L; Zhang J; Roberts AI; Zhang H; Das G; Shi Y. 2008. Apoptotic cells induce immunosuppression through dendritic cells: critical roles of IFN-gamma and nitric oxide. J Immunol 181(5):3277-84. [PubMed: 18713999]  [MGI Ref ID J:138951]

Reynolds CM; Suliman HB; Hollingsworth JW; Welty-Wolf KE; Carraway MS; Piantadosi CA. 2009. Nitric oxide synthase-2 induction optimizes cardiac mitochondrial biogenesis after endotoxemia. Free Radic Biol Med 46(5):564-72. [PubMed: 19073249]  [MGI Ref ID J:145176]

Rivera J; Mukherjee J; Weiss LM; Casadevall A. 2002. Antibody Efficacy in Murine Pulmonary Cryptococcus neoformans Infection: A Role for Nitric Oxide. J Immunol 168(7):3419-27. [PubMed: 11907100]  [MGI Ref ID J:75578]

Rocha FJ; Schleicher U; Mattner J; Alber G; Bogdan C. 2007. Cytokines, signaling pathways, and effector molecules required for the control of Leishmania (Viannia) braziliensis in mice. Infect Immun 75(8):3823-32. [PubMed: 17517868]  [MGI Ref ID J:123377]

Rosypal AC; Lindsay DS; Duncan R Jr; Ahmed SA; Zajac AM; Dubey JP. 2002. Mice lacking the gene for inducible or endothelial nitric oxide are resistant to sporocyst induced Sarcocystis neurona infections. Vet Parasitol 103(4):315-21. [PubMed: 11777610]  [MGI Ref ID J:106322]

Rothfuchs AG; Gigliotti D; Palmblad K; Andersson U; Wigzell H; Rottenberg ME. 2001. IFN-alphabeta-dependent, IFN-gamma secretion by bone marrow-derived macrophages controls an intracellular bacterial infection. J Immunol 167(11):6453-61. [PubMed: 11714812]  [MGI Ref ID J:72825]

Rottenberg ME; Gigliotti Rothfuchs AC; Gigliotti D; Svanholm C; Bandholtz L; Wigzell H. 1999. Role of innate and adaptive immunity in the outcome of primary infection with Chlamydia pneumoniae, as analyzed in genetically modified mice. J Immunol 162(5):2829-36. [PubMed: 10072530]  [MGI Ref ID J:124536]

Rudkowski JC; Barreiro E; Harfouche R; Goldberg P; Kishta O; D'Orleans-Juste P; Labonte J; Lesur O; Hussain SN. 2004. Roles of iNOS and nNOS in sepsis-induced pulmonary apoptosis. Am J Physiol Lung Cell Mol Physiol 286(4):L793-800. [PubMed: 14660484]  [MGI Ref ID J:108149]

Sam F; Sawyer DB; Xie Z; Chang DL; Ngoy S; Brenner DA; Siwik DA; Singh K; Apstein CS; Colucci WS. 2001. Mice lacking inducible nitric oxide synthase have improved left ventricular contractile function and reduced apoptotic cell death late after myocardial infarction. Circ Res 89(4):351-6. [PubMed: 11509452]  [MGI Ref ID J:115413]

Sato K; Ozaki K; Oh I; Meguro A; Hatanaka K; Nagai T; Muroi K; Ozawa K. 2007. Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells. Blood 109(1):228-34. [PubMed: 16985180]  [MGI Ref ID J:142176]

Scanga CA; Mohan VP; Tanaka K; Alland D; Flynn JL; Chan J. 2001. The Inducible Nitric Oxide Synthase Locus Confers Protection against Aerogenic Challenge of Both Clinical and Laboratory Strains of Mycobacterium tuberculosis in Mice. Infect Immun 69(12):7711-7. [PubMed: 11705952]  [MGI Ref ID J:73135]

Scott DJ; Hull MA; Cartwright EJ; Lam WK; Tisbury A; Poulsom R; Markham AF; Bonifer C; Coletta PL. 2001. Lack of inducible nitric oxide synthase promotes intestinal tumorigenesis in the apc(min/+) mouse. Gastroenterology 121(4):889-99. [PubMed: 11606502]  [MGI Ref ID J:72030]

Sercan O; Hammerling GJ; Arnold B; Schuler T. 2006. Innate immune cells contribute to the IFN-gamma-dependent regulation of antigen-specific CD8+ T cell homeostasis. J Immunol 176(2):735-9. [PubMed: 16393956]  [MGI Ref ID J:126599]

Seril DN; Liao J; Yang GY. 2007. Colorectal carcinoma development in inducible nitric oxide synthase-deficient mice with dextran sulfate sodium-induced ulcerative colitis. Mol Carcinog 46(5):341-53. [PubMed: 17219424]  [MGI Ref ID J:121634]

Shesely EG; Maeda N; Kim HS; Desai KM; Krege JH; Laubach VE; Sherman PA; Sessa WC; Smithies O. 1996. Elevated blood pressures in mice lacking endothelial nitric oxide synthase. Proc Natl Acad Sci U S A 93(23):13176-81. [PubMed: 8917564]  [MGI Ref ID J:36559]

Simmons CP; Goncalves NS; Ghaem-Maghami M; Bajaj-Elliott M; Clare S; Neves B; Frankel G; Dougan G; MacDonald TT. 2002. Impaired resistance and enhanced pathology during infection with a noninvasive, attaching-effacing enteric bacterial pathogen, Citrobacter rodentium, in mice lacking IL-12 or IFN-gamma. J Immunol 168(4):1804-12. [PubMed: 11823513]  [MGI Ref ID J:74480]

Somers JR; Beck PL; Lees-Miller JP; Roach D; Li Y; Guo J; Loken S; Zhan S; Semeniuk L; Duff HJ. 2008. iNOS in cardiac myocytes plays a critical role in death in a murine model of hypertrophy induced by calcineurin. Am J Physiol Heart Circ Physiol 295(3):H1122-H1131. [PubMed: 18621856]  [MGI Ref ID J:141285]

Speyer CL; Neff TA; Warner RL; Guo RF; Sarma JV; Riedemann NC; Murphy ME; Murphy HS; Ward PA. 2003. Regulatory effects of iNOS on acute lung inflammatory responses in mice. Am J Pathol 163(6):2319-28. [PubMed: 14633605]  [MGI Ref ID J:86598]

Spohr F; Cornelissen AJ; Busch C; Gebhard MM; Motsch J; Martin EO; Weimann J. 2005. Role of endogenous nitric oxide in endotoxin-induced alteration of hypoxic pulmonary vasoconstriction in mice. Am J Physiol Heart Circ Physiol 289(2):H823-31. [PubMed: 15778287]  [MGI Ref ID J:100323]

Stadler K; Bonini MG; Dallas S; Duma D; Mason RP; Kadiiska MB. 2008. Direct evidence of iNOS-mediated in vivo free radical production and protein oxidation in acetone-induced ketosis. Am J Physiol Endocrinol Metab 295(2):E456-62. [PubMed: 18559982]  [MGI Ref ID J:139996]

Strobl B; Bubic I; Bruns U; Steinborn R; Lajko R; Kolbe T; Karaghiosoff M; Kalinke U; Jonjic S; Muller M. 2005. Novel functions of tyrosine kinase 2 in the antiviral defense against murine cytomegalovirus. J Immunol 175(6):4000-8. [PubMed: 16148148]  [MGI Ref ID J:116703]

Sugimura Y; Murase T; Oyama K; Uchida A; Sato N; Hayasaka S; Kano Y; Takagishi Y; Hayashi Y; Oiso Y; Murata Y. 2009. Prevention of neural tube defects by loss of function of inducible nitric oxide synthase in fetuses of a mouse model of streptozotocin-induced diabetes. Diabetologia 52(5):962-71. [PubMed: 19283362]  [MGI Ref ID J:148113]

Sugita H; Fujimoto M; Yasukawa T; Shimizu N; Sugita M; Yasuhara S; Martyn JA; Kaneki M. 2005. Inducible nitric-oxide synthase and NO donor induce insulin receptor substrate-1 degradation in skeletal muscle cells. J Biol Chem 280(14):14203-11. [PubMed: 15805118]  [MGI Ref ID J:98746]

Tangpong J; Sompol P; Vore M; St Clair W; Butterfield DA; St Clair DK. 2008. Tumor necrosis factor alpha-mediated nitric oxide production enhances manganese superoxide dismutase nitration and mitochondrial dysfunction in primary neurons: an insight into the role of glial cells. Neuroscience 151(2):622-9. [PubMed: 18160224]  [MGI Ref ID J:130957]

Tao F; Tao YX; Mao P; Zhao C; Li D; Liaw WJ; Raja SN; Johns RA. 2003. Intact carrageenan-induced thermal hyperalgesia in mice lacking inducible nitric oxide synthase. Neuroscience 120(3):847-54. [PubMed: 12895524]  [MGI Ref ID J:126175]

Tatemichi M; Ogura T; Sakurazawa N; Nagata H; Sugita M; Esumi H. 2003. Roles of inducible nitric oxide synthase in the development and healing of experimentally induced gastric ulcers. Int J Exp Pathol 84(5):213-20. [PubMed: 14690480]  [MGI Ref ID J:87317]

Tavener SA; Kubes P. 2006. Cellular and molecular mechanisms underlying LPS-associated myocyte impairment. Am J Physiol Heart Circ Physiol 290(2):H800-6. [PubMed: 16172157]  [MGI Ref ID J:106721]

TeKippe M; Harrison DE; Chen J. 2003. Expansion of hematopoietic stem cell phenotype and activity in Trp53-null mice. Exp Hematol 31(6):521-7. [PubMed: 12829028]  [MGI Ref ID J:115677]

Theodorakis NG; Wang YN; Skill NJ; Metz MA; Cahill PA; Redmond EM; Sitzmann JV. 2003. The role of nitric oxide synthase isoforms in extrahepatic portal hypertension: studies in gene-knockout mice. Gastroenterology 124(5):1500-8. [PubMed: 12730888]  [MGI Ref ID J:107756]

Thoeni G; Stoitzner P; Brandacher G; Romani N; Heufler C; Werner-Felmayer G; Werner ER. 2005. Tetrahydro-4-aminobiopterin attenuates dendritic cell-induced T cell priming independently from inducible nitric oxide synthase. J Immunol 174(12):7584-91. [PubMed: 15944258]  [MGI Ref ID J:100788]

Tranguch S; Huet-Hudson Y. 2003. Decreased viability of nitric oxide synthase double knockout mice. Mol Reprod Dev 65(2):175-9. [PubMed: 12704728]  [MGI Ref ID J:83112]

Uppington H; Menager N; Boross P; Wood J; Sheppard M; Verbeek S; Mastroeni P. 2006. Effect of immune serum and role of individual Fcgamma receptors on the intracellular distribution and survival of Salmonella enterica serovar Typhimurium in murine macrophages. Immunology 119(2):147-58. [PubMed: 16836651]  [MGI Ref ID J:118526]

Vareniuk I; Pavlov IA; Obrosova IG. 2008. Inducible nitric oxide synthase gene deficiency counteracts multiple manifestations of peripheral neuropathy in a streptozotocin-induced mouse model of diabetes. Diabetologia 51(11):2126-33. [PubMed: 18802679]  [MGI Ref ID J:142727]

Vig M; Srivastava S; Kandpal U; Sade H; Lewis V; Sarin A; George A; Bal V; Durdik JM; Rath S. 2004. Inducible nitric oxide synthase in T cells regulates T cell death and immune memory. J Clin Invest 113(12):1734-42. [PubMed: 15199408]  [MGI Ref ID J:90903]

Villalta SA; Nguyen HX; Deng B; Gotoh T; Tidball JG. 2009. Shifts in macrophage phenotypes and macrophage competition for arginine metabolism affect the severity of muscle pathology in muscular dystrophy. Hum Mol Genet 18(3):482-96. [PubMed: 18996917]  [MGI Ref ID J:143545]

Vissers YL; Hallemeesch MM; Soeters PB; Lamers WH; Deutz NE. 2004. NOS2 deficiency increases intestinal metabolism both in nonstimulated and endotoxemic mice. Am J Physiol Gastrointest Liver Physiol 286(5):G747-51. [PubMed: 14656712]  [MGI Ref ID J:95679]

Wang LF; Mehta S; Weicker S; Scott JA; Joseph M; Razavi HM; McCormack DG. 2001. Relative contribution of hemopoietic and pulmonary parenchymal cells to lung inducible nitric oxide synthase (inos) activity in murine endotoxemia. Biochem Biophys Res Commun 283(3):694-9. [PubMed: 11341781]  [MGI Ref ID J:114281]

Wang T. 2002. Role of iNOS and eNOS in modulating proximal tubule transport and acid-base balance. Am J Physiol Renal Physiol 283(4):F658-62. [PubMed: 12217856]  [MGI Ref ID J:113614]

Watanuki M; Sakai A; Sakata T; Tsurukami H; Miwa M; Uchida Y; Watanabe K; Ikeda K; Nakamura T. 2002. Role of inducible nitric oxide synthase in skeletal adaptation to acute increases in mechanical loading. J Bone Miner Res 17(6):1015-25. [PubMed: 12054156]  [MGI Ref ID J:112399]

White JK; Mastroeni P; Popoff JF; Evans CA; Blackwell JM. 2005. Slc11a1-mediated resistance to Salmonella enterica serovar Typhimurium and Leishmania donovani infections does not require functional inducible nitric oxide synthase or phagocyte oxidase activity. J Leukoc Biol 77(3):311-20. [PubMed: 15601666]  [MGI Ref ID J:97453]

Wilcock DM; Gharkholonarehe N; Van Nostrand WE; Davis J; Vitek MP; Colton CA. 2009. Amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer's disease. J Neurosci 29(25):7957-65. [PubMed: 19553436]  [MGI Ref ID J:150418]

Wilcock DM; Lewis MR; Van Nostrand WE; Davis J; Previti ML; Gharkholonarehe N; Vitek MP; Colton CA. 2008. Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2. J Neurosci 28(7):1537-45. [PubMed: 18272675]  [MGI Ref ID J:132221]

Wilcock DM; Vitek MP; Colton CA. 2009. Vascular amyloid alters astrocytic water and potassium channels in mouse models and humans with Alzheimer's disease. Neuroscience 159(3):1055-69. [PubMed: 19356689]  [MGI Ref ID J:148938]

Wipke BT; Allen PM. 2001. Essential role of neutrophils in the initiation and progression of a murine model of rheumatoid arthritis. J Immunol 167(3):1601-8. [PubMed: 11466382]  [MGI Ref ID J:120467]

Wood KC; Hebbel RP; Lefer DJ; Granger DN. 2006. Critical role of endothelial cell-derived nitric oxide synthase in sickle cell disease-induced microvascular dysfunction. Free Radic Biol Med 40(8):1443-53. [PubMed: 16631534]  [MGI Ref ID J:108238]

Wu D; Xu C; Cederbaum A. 2009. Role of nitric oxide and nuclear factor-kappaB in the CYP2E1 potentiation of tumor necrosis factor alpha hepatotoxicity in mice. Free Radic Biol Med 46(4):480-91. [PubMed: 19063961]  [MGI Ref ID J:145179]

Wuthrich M; Filutowicz HI; Warner T; Klein BS. 2002. Requisite elements in vaccine immunity to Blastomyces dermatitidis: plasticity uncovers vaccine potential in immune-deficient hosts. J Immunol 169(12):6969-76. [PubMed: 12471131]  [MGI Ref ID J:118419]

Xi L; Jarrett NC; Hess ML; Kukreja RC. 1999. Essential role of inducible nitric oxide synthase in monophosphoryl lipid A-induced late cardioprotection: evidence from pharmacological inhibition and gene knockout mice. Circulation 99(16):2157-63. [PubMed: 10217657]  [MGI Ref ID J:54841]

Xi L; Jarrett NC; Hess ML; Kukreja RC. 1999. Myocardial ischemia/reperfusion injury in the inducible nitric oxide synthase knockout mice. Life Sci 65(9):935-45. [PubMed: 10465353]  [MGI Ref ID J:57432]

Xu G; Zhang Y; Zhang L; Ren G; Shi Y. 2008. Bone marrow stromal cells induce apoptosis of lymphoma cells in the presence of IFNgamma and TNF by producing nitric oxide. Biochem Biophys Res Commun 375(4):666-70. [PubMed: 18755151]  [MGI Ref ID J:140996]

Yang JZ; Ajonuma LC; Rowlands DK; Tsang LL; Ho LS; Lam SY; Chen WY; Zhou CX; Chung YW; Cho CY; Tse JY; James AE; Chan HC. 2005. The role of inducible nitric oxide synthase in gamete interaction and fertilization: a comparative study on knockout mice of three NOS isoforms. Cell Biol Int 29(9):785-91. [PubMed: 16087361]  [MGI Ref ID J:112824]

Yang S; Porter VA; Cornfield DN; Milla C; Panoskaltsis-Mortari A; Blazar BR; Haddad IY. 2001. Effects of oxidant stress on inflammation and survival of iNOS knockout mice after marrow transplantation. Am J Physiol Lung Cell Mol Physiol 281(4):L922-30. [PubMed: 11557596]  [MGI Ref ID J:72096]

Yerushalmi HF; Besselsen DG; Ignatenko NA; Blohm-Mangone KA; Padilla-Torres JL; Stringer DE; Cui H; Holubec H; Payne CM; Gerner EW. 2006. The role of NO synthases in arginine-dependent small intestinal and colonic carcinogenesis. Mol Carcinog 45(2):93-105. [PubMed: 16329147]  [MGI Ref ID J:107079]

Yook YH; Kang KH; Maeng O; Kim TR; Lee JO; Kang KI; Kim YS; Paik SG; Lee H. 2004. Nitric oxide induces BNIP3 expression that causes cell death in macrophages. Biochem Biophys Res Commun 321(2):298-305. [PubMed: 15358175]  [MGI Ref ID J:91305]

Zaki MH; Fujii S; Okamoto T; Islam S; Khan S; Ahmed KA; Sawa T; Akaike T. 2009. Cytoprotective function of heme oxygenase 1 induced by a nitrated cyclic nucleotide formed during murine salmonellosis. J Immunol 182(6):3746-56. [PubMed: 19265153]  [MGI Ref ID J:145919]

Zaragoza C; Lopez-Rivera E; Garcia-Rama C; Saura M; Martinez-Ruiz A; Lizarbe TR; Martin-de-Lara F; Lamas S. 2006. Cbfa-1 mediates nitric oxide regulation of MMP-13 in osteoblasts. J Cell Sci 119(Pt 9):1896-902. [PubMed: 16636074]  [MGI Ref ID J:108930]

Zaragoza C; Ocampo CJ; Saura M; Bao C; Leppo M; Lafond-Walker A; Thiemann DR; Hruban R; Lowenstein CJ. 1999. Inducible nitric oxide synthase protection against coxsackievirus pancreatitis. J Immunol 163(10):5497-504. [PubMed: 10553076]  [MGI Ref ID J:58451]

Zeidler PC; Millecchia LM; Castranova V. 2004. Role of inducible nitric oxide synthase-derived nitric oxide in lipopolysaccharide plus interferon-gamma-induced pulmonary inflammation. Toxicol Appl Pharmacol 195(1):45-54. [PubMed: 14962504]  [MGI Ref ID J:87978]

Zell JA; Ignatenko NA; Yerushalmi HF; Ziogas A; Besselsen DG; Gerner EW; Anton-Culver H. 2007. Risk and risk reduction involving arginine intake and meat consumption in colorectal tumorigenesis and survival. Int J Cancer 120(3):459-68. [PubMed: 17096347]  [MGI Ref ID J:117825]

Zhang P; Xu X; Hu X; van Deel ED; Zhu G; Chen Y. 2007. Inducible nitric oxide synthase deficiency protects the heart from systolic overload-induced ventricular hypertrophy and congestive heart failure. Circ Res 100(7):1089-98. [PubMed: 17363700]  [MGI Ref ID J:133913]

Zhao T; Xi L; Chelliah J; Levasseur JE; Kukreja RC. 2000. Inducible nitric oxide synthase mediates delayed myocardial protection induced by activation of adenosine A(1) receptors: evidence from gene-knockout mice. Circulation 102(8):902-7. [PubMed: 10952960]  [MGI Ref ID J:103302]

Zhao Y; Ferguson DJ; Wilson DC; Howard JC; Sibley LD; Yap GS. 2009. Virulent Toxoplasma gondii evade immunity-related GTPase-mediated parasite vacuole disruption within primed macrophages. J Immunol 182(6):3775-81. [PubMed: 19265156]  [MGI Ref ID J:145916]

Zhou J; Dehne N; Brune B. 2009. Nitric oxide causes macrophage migration via the HIF-1-stimulated small GTPases Cdc42 and Rac1. Free Radic Biol Med 47(6):741-9. [PubMed: 19523512]  [MGI Ref ID J:152571]

Zhu B; Bando Y; Xiao S; Yang K; Anderson AC; Kuchroo VK; Khoury SJ. 2007. CD11b+Ly-6C(hi) suppressive monocytes in experimental autoimmune encephalomyelitis. J Immunol 179(8):5228-37. [PubMed: 17911608]  [MGI Ref ID J:153031]

Zhu DY; Liu SH; Sun HS; Lu YM. 2003. Expression of inducible nitric oxide synthase after focal cerebral ischemia stimulates neurogenesis in the adult rodent dentate gyrus. J Neurosci 23(1):223-9. [PubMed: 12514219]  [MGI Ref ID J:124823]

Zhu X; Zhao H; Graveline AR; Buys ES; Schmidt U; Bloch KD; Rosenzweig A; Chao W. 2006. MyD88 and NOS2 are essential for toll-like receptor 4-mediated survival effect in cardiomyocytes. Am J Physiol Heart Circ Physiol 291(4):H1900-9. [PubMed: 16648192]  [MGI Ref ID J:116319]

Zingarelli B; Szabo C; Salzman AL. 1999. Reduced oxidative and nitrosative damage in murine experimental colitis in the absence of inducible nitric oxide synthase. Gut 45(2):199-209. [PubMed: 10403731]  [MGI Ref ID J:56980]

de Jonge WJ; Hallemeesch MM; Kwikkers KL; Ruijter JM; de Gier-de Vries C; van Roon MA; Meijer AJ; Marescau B; de Deyn PP; Deutz NE; Lamers WH. 2002. Overexpression of arginase I in enterocytes of transgenic mice elicits a selective arginine deficiency and affects skin, muscle, and lymphoid development. Am J Clin Nutr 76(1):128-40. [PubMed: 12081826]  [MGI Ref ID J:80556]

de Jonge WJ; Kwikkers KL; te Velde AA; van Deventer SJ; Nolte MA; Mebius RE; Ruijter JM; Lamers MC; Lamers WH. 2002. Arginine deficiency affects early B cell maturation and lymphoid organ development in transgenic mice. J Clin Invest 110(10):1539-48. [PubMed: 12438451]  [MGI Ref ID J:80204]

van Der Heyde HC; Gu Y; Zhang Q; Sun G; Grisham MB. 2000. Nitric oxide is neither necessary nor sufficient for resolution of plasmodium chabaudi malaria in mice J Immunol 165(6):3317-23. [PubMed: 10975849]  [MGI Ref ID J:64564]

van Rossum AM; Lysenko ES; Weiser JN. 2005. Host and bacterial factors contributing to the clearance of colonization by Streptococcus pneumoniae in a murine model. Infect Immun 73(11):7718-26. [PubMed: 16239576]  [MGI Ref ID J:104292]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           A1

Colony Maintenance

Mating System	Homozygote x Homozygote         (Female x Male)   01-MAR-06

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Standard Supply	Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement.
Supply Notes	Usually shipped between four and eight weeks of age. This strain is included in the Mouse Mutant Resource collection. Genomic DNA is available for this strain from the Mouse DNA Resource.
Important Note
This strain is homozygous for Nos2tm1Lau.

Control Information

	Control
	002609 B6.129P2-Nos2tm1Lau/J
	000664 C57BL/6J
		Because chtl arose on B6.129P2-Nos2tm1Lau/J (Stock # 002609) and this chtl-bearing subline remains homozygous for the targeted mutation, B6.129P2-Nos2tm1Lau/J (Stock # 002609) is the best available control for this strain.
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USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
International - Control Pricing Information for Genetically Engineered Mutant Strains.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

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No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. In purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.