Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Deletion; Additional information on Mice with Chromosomal Aberrations. Type Mutant Stock; Radiation Induced Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation N1pN1 Generation Definitions

Development
T stock is a tester stock homozygous for seven recessive alleles, a, Tyrp^b, Tyr^c-ch, p, Myo5a^d, Bmp5^se, and Ednrb^s. (Russell et al. 1979. Genetics v.91 p.127). (101/Rl x C3H/Rl)F1 males were mutagenized by exposure to plutonium-239 and bred with T stock Females to identify those carrying recessive mutations allelic with Ednrb^s. Proven heterozygotes were bred to CAST/Ei, which permits identification of the mutant versus CAST/Ei chromosomes through a D14Mit8 polymorphism. Ednrb^s-52Pub heterozygous male offspring were sent from Liane Russell at Oak Ridge National Laboratory to The Jackson Laboratory in July 1997 and bred with C57BL/6J females for re-derivation. In 2003 heterozygous males, from a cross of a heterozygote to BCByB6F1/J, were used for cryopreservation of sperm.

Related Strains

Deletion

005535	B6.129S7-Del(11Cops3-Rnf112)1Jrl/J
003374	B6;129S2-H2dlAb1-Ea/J
005654	B6C3-Del(16Cbr1-ORF9)1Rhr/J
002802	C3.BLiA Pde6b+-Krd/J
004406	C3HeB/FeJ-Pou3f4del-J/J
002142	STOCK 11R30m/J

View Deletion     (6 strains)

Strains carrying other alleles of Ednrb

000577	B6 x STOCK a Oca2p Hps5ru2 Ednrbs/J
011080	B6;129-Ednrbtm1.1Nat/J
003295	B6;129-Ednrbtm1Ywa/J
000674	I/LnJ
003720	JF1/Ms
000676	LP/J
000308	SSL/LeJ
009063	STOCK Ednrbtm1Nrd/J
000275	V/LeJ

View Strains carrying other alleles of Ednrb     (9 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI

- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested. Abcd Syndrome; ABCDS   (EDNRB) Hirschsprung Disease, Susceptibility to, 2; HSCR2   (EDNRB) Waardenburg Syndrome, Type 4A; WS4A   (EDNRB)

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI

      assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX^® Mice strain.

Ednrb^s-52Pub/Ednrb⁺

        involves: 101/Rl * C3H/Rl

• growth/size phenotype
• decreased body size
  • described as small and runted   (MGI Ref ID J:100221)

Ednrb^s-52Pub/Ednrb^s-52Pub

        involves: 101/Rl * C3H/Rl

• mortality/aging
• complete prenatal lethality   (MGI Ref ID J:100221)

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Ednrb^s-52Pub related

Dermatology Research
Color and White Spotting Defects

Developmental Biology Research
Embryonic Lethality (Homozygous)
Neural Crest Defects

Research Tools
Genetics Research
      Gene Mapping

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol		Ednrbs-52Pub
Allele Name		Pu239 citrate alpha ray induced 52Pub
Allele Type		Radiation induced
Common Name(s)		Ednrbs-38R; s52Pub;
Strain of Origin		(101/Rl x C3H/Rl)F1
Gene Symbol and Name		Ednrb, endothelin receptor type B
Chromosome		14
Gene Common Name(s)		ABCDS; AU022549; ET-B; ET-BR; ETB; ETBR; ETR-b; ETRB; Ednra; HSCR; HSCR2; Sox10m1; WS4A; expressed sequence AU022549; piebald; s;
General Note		This allele was induced by [alpha-239]-Pu: Plutonium citrate (alpha particles).
Molecular Note		Large intergenic deletion.

Genotyping

Genotyping Information

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Roix J; Hagge-Greenberg A; Bissonnette D; Rodick S; Russell L; O'Brien T. 2001. Molecular and functional mapping of the piebald deletion complex on mouse chromosome 14. Genetics 157(2):803-15. [PubMed: 11156998]  [MGI Ref ID J:67314]

Additional References

Ednrb^s-52Pub related

Oak Ridge National Laboratory. 2005. Information obtained from the Oak Ridge National Laboratory Mutant Mouse Database (ORNL), Oak Ridge, TN Unpublished :.  [MGI Ref ID J:100221]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

---

Ordering Information
JAX^® Mice
Surgical and Preconditioning Services
JAX^® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use

General Terms and Conditions

Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:	207-288-6470
fax:	207-288-6655

JAX^® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.