Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Deletion; Additional information on Mice with Chromosomal Aberrations. Type Mutant Stock; Radiation Induced Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation N1pN1

Development
T stock is a tester stock homozygous for seven recessive alleles, a, Tyrp^b, Tyr^c-ch, p, Myo5a^d, Bmp5^se, and Ednrb^s. (Russell et al. 1979. Genetics v.91 p.127). (101/Rl x C3H/Rl)F1 males were mutagenized by exposure to plutonium-239 and bred with T stock Females to identify those carrying recessive mutations allelic with Ednrb^s. Proven heterozygotes were bred to CAST/Ei, which permits identification of the mutant versus CAST/Ei chromosomes through a D14Mit8 polymorphism. Ednrb^s-52Pub heterozygous male offspring were sent from Liane Russell at Oak Ridge National Laboratory to The Jackson Laboratory in July 1997 and bred with C57BL/6J females for re-derivation. In 2003 heterozygous males, from a cross of a heterozygote to BCByB6F1/J, were used for cryopreservation of sperm.

Related Strains

Deletion

005535	B6.129S7-Del(11Cops3-Zfp179)1Jrl/J
003374	B6;129S2-H2dlAb1-Ea/J
005654	B6C3-Del(16Cbr1-ORF9)1Rhr/J
002802	C3.BLiA Pde6b+-Krd/J
004406	C3HeB/FeJ-Pou3f4del-J/J
002142	STOCK 11R30m/J

View Deletion     (6 strains)

Strains carrying other alleles of Ednrb

000577	B6 x STOCK a Oca2p Hps5ru2 Ednrbs/J
003295	B6;129-Ednrbtm1Ywa/J
000674	I/LnJ
000676	LP/J
000308	SSL/LeJ
009063	STOCK Ednrbtm1Nrd/J
000275	V/LeJ

View Strains carrying other alleles of Ednrb     (7 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms

      assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX^® Mice strain.

Ednrb^s-52Pub/Ednrb⁺

        involves: 101/Rl * C3H/Rl

• growth/size phenotype
• decreased body size (MGI Ref ID J:100221)
  • described as small and runted

Ednrb^s-52Pub/Ednrb^s-52Pub

        involves: 101/Rl * C3H/Rl

• lethality-prenatal/perinatal
• prenatal lethality (MGI Ref ID J:100221)

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Ednrb^s-52Pub related

Dermatology Research
Color and White Spotting Defects

Developmental Biology Research
Embryonic Lethality (Homozygous)
Neural Crest Defects

Research Tools
Genetics Research
      Gene Mapping

Genes & Alleles

Gene & Allele Information

Allele Symbol		Ednrbs-52Pub
Allele Name		Pu239 citrate alpha ray induced 52Pub
Allele Type		Radiation induced
Common Name(s)		Ednrbs-38R; s52Pub;
Strain of Origin		(101/Rl x C3H/Rl)F1
Gene Symbol and Name		Ednrb, endothelin receptor type B
Chromosome		14
Gene Common Name(s)		ABCDS; AU022549; ETB; ETBR; ETR-b; ETRB; Ednra; HSCR; HSCR2; Sox10m1; expressed sequence AU022549; piebald; s;
General Note		This allele was induced by [alpha-239]-Pu: Plutonium citrate (alpha particles).
Molecular Note		Large intergenic deletion.

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Genotyping resources and troubleshooting

References

References

Selected Reference(s)

Roix J; Hagge-Greenberg A; Bissonnette D; Rodick S; Russell L; O'Brien T. 2001. Molecular and functional mapping of the piebald deletion complex on mouse chromosome 14. Genetics 157(2):803-15. [PubMed: 11156998]  [MGI Ref ID J:67314]

Additional References

Ednrb^s-52Pub related

Mouse Genome Informatics (MGI). 2005. Information obtained from the Oak Ridge National Laboratory Mutant Mouse Database (ORNL), Oak Ridge, TN (http://bio.lsd.ornl.gov/mouse/) :.  [MGI Ref ID J:100221]

Health & husbandry

Health & Colony Maintenance Information

Currently there no information available for this strain. This may be due to the supply level of this strain.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Supply Details

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.

Supply Notes

Cryorecovery - Standard. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Ordering and Purchasing Information

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Terms of Use

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