Strain Name: |
STOCK Ednrbs-52Pub |
|---|---|
Stock Number: |
004711 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Genes & Alleles | Ednrb; Ednrbs-52Pub; |
Product Information
Strain Details
Type Deletion Additional information on Mice with Chromosomal Aberrations. Type JAX® GEMM® Strain - Mutant Stock Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Radiation Induced Mutation Species laboratory mouse Generation N1pN1 Strain Development
T stock is a tester stock homozygous for seven recessive alleles, a, Tyrpb, Tyrc-ch, p, Myo5ad, Bmp5se, and Ednrbs. (Russell et al. 1979. Genetics v.91 p.127). (101/Rl x C3H/Rl)F1 males were mutagenized by exposure to plutonium-239 and bred with T stock Females to identify those carrying recessive mutations allelic with Ednrbs. Proven heterozygotes were bred to CAST/Ei, which permits identification of the mutant versus CAST/Ei chromosomes through a D14Mit8 polymorphism. Ednrbs-52Pub heterozygous male offspring were sent from Liane Russell at Oak Ridge National Laboratory to The Jackson Laboratory in July 1997 and bred with C57BL/6J females for re-derivation. In 2003 heterozygous males, from a cross of a heterozygote to BCByB6F1/J, were used for cryopreservation of sperm.
Gene & Allele Details
| Allele Symbol | Ednrbs-52Pub | ||
|---|---|---|---|
| Allele Name | Pu239 citrate alpha ray induced 52Pub | ||
| Common Name(s) | s52Pub; | ||
| Strain of Origin | (101/Rl x C3H/Rl)F1 | ||
| Gene Symbol and Name | Ednrb, endothelin receptor type B | ||
| Chromosome | 14 | ||
| Gene Common Name(s) | ABCDS; AU022549; ETB; ETBR; ETRB; Ednra; HSCR; HSCR2; Sox10m1; expressed sequence AU022549; piebald; s; | ||
| General Note | This allele was induced by [alpha-239]-Pu: Plutonium citrate (alpha particles). | ||
| Molecular Note | Large intergenic deletion. | ||
Related Strains
Deletion
005535 B6.129S7-Del(11Cops3-Zfp179)1Jrl/J 003374 B6;129S2-H2dlAb1-Ea/J 005654 B6C3-Del(16Cbr1-ORF9)1Rhr/J 002802 C3.BLiA Pde6b+-Krd/J 004406 C3HeB/FeJ-Pou3f4del-J/J 002142 STOCK 11R30m/J View Deletion (6 strains)
000577 B6 x STOCK a Oca2p Hps5ru2 Ednrbs/J 003295 B6;129-Ednrbtm1Ywa/J 000674 I/LnJ 000676 LP/J 000308 SSL/LeJ 000275 V/LeJ
Research Applications
This mouse can be used to support research in many areas including:Ednrbs-52Pub related
Dermatology Research
Color and White Spotting Defects
Developmental Biology Research
Embryonic Lethality (Homozygous)
Neural Crest Defects
Research Tools
Genetics Research (Gene Mapping)
References
Selected Reference(s)
Roix J; Hagge-Greenberg A; Bissonnette D; Rodick S; Russell L; O'Brien T. 2001. Molecular and functional mapping of the piebald deletion complex on mouse chromosome 14. Genetics 157(2):803-15. [PubMed: 11156998] [MGI Ref ID J:67314]
Price and Supply Information
| Strain Name: | STOCK Ednrbs-52Pub |
| Stock Number: | 004711 |
Price Details
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to the Supply Notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below |
General Terms and Conditions
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The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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