Strain Name:

B6.129-Bace1tm1Pcw/J

Stock Number:

004714

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Availability:

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Use Restrictions Apply, see Terms of Use
Primary cultures of cortical neurons isolated from homozygotes aged embryonic day 16.5 do not secrete amyloid beta peptides or beta C-terminal fragments. This mutant mouse strain may be useful in studies of Alzheimer's disease.

Description

Strain Information

Former Names B6.129-Bacetm1Pcw/J    (Changed: 15-DEC-04 )
Type Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Specieslaboratory mouse
GenerationN7F?+N1F13 (11-APR-11)
Generation Definitions
 
Donating Investigator Philip C. Wong,   Johns Hopkins University

Description
Mice that are homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. No gene product (protein) is detected by Western blot analysis of brain tissue. Primary cultures of cortical neurons isolated from homozygotes aged embryonic day 16.5 do not secrete amyloid beta peptides (Aβ1-40/42 or Aβ11-40/42) or beta C-terminal fragments (βCTFs). When transfected with a recombinant adenovirus expressing the mutant humanized Beta amyloid precursor protein (APP), hAPPSwe, cultured embryonic cortical neurons do not secrete detectable levels of Aβ1-40/42 or Aβ11-40/42 peptides. This mutant mouse strain may be useful in studies of Alzheimer's disease.

Development
A targeting vector containing neomycin resistance and herpes simplex virus thymidine kinase genes was used to disrupt 2kb of sequence containing exon 1 of the targeted gene. The construct was electroporated into 129-derived R1 embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6J blastocysts. The resulting chimeric animals were crossed to C57BL/6 mice, and then backcrossed to the same for 7 generations.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

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View Alzheimer's Disease Models     (109 strains)

Additional Web Information

Visit the Alzheimer's Disease Mouse Model Resource site for helpful information on Alzheimer's Disease and research resources.

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Bace1tm1Pcw/Bace1tm1Pcw

        involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
  • behavior/neurological phenotype
  • abnormal locomotor activation
    • swimming speed is lower than controls in Morris water maze   (MGI Ref ID J:123534)
  • abnormal spatial learning   (MGI Ref ID J:123534)
  • abnormal spatial reference memory
    • in Morris water maze, 3-month old mice show normal learning and memory for location of hidden platform, but at 16 months, mutant animals display significantly impaired spatial reference memory during probe trials compared to normal or heterozygous littermates, while performance in hidden platform trials is not significantly different   (MGI Ref ID J:123534)
  • abnormal spatial working memory
    • in spatial working memory tasks using the radial arm water maze, mice are significantly impaired compared to littermates; deficit is observed in Y-maze task, with mutant animals showing deficits in arm alternation   (MGI Ref ID J:123534)
  • decreased anxiety-related response
    • in an open-field task, mice display low anxiety-type behavior like greater distance traveled and more frequent and active visits to open center of field compared to control heterozygotes and wild-type mice   (MGI Ref ID J:123534)
  • nervous system phenotype
  • abnormal long term depression
    • after LTD saturation, mice display a larger de-depression than controls   (MGI Ref ID J:123534)
  • enhanced paired-pulse facilitation
    • the PPF ratio is significantly increased at short interstimulus intervals (ISIs) relative to controls, but not at long ISIs   (MGI Ref ID J:123534)

Bace1tm1Pcw/Bace1tm1Pcw

        involves: 129S1/Sv * 129X1/SvJ
  • behavior/neurological phenotype
  • decreased grip strength
    • mice show reduced grip strength (1.13) relative to wild-type controls (1.26)   (MGI Ref ID J:116162)
  • decreased thermal nociceptive threshold
    • mutants retract paws from thermal stimulus more rapidly than wild-type controls, indicating greater pain sensitivity   (MGI Ref ID J:116162)
  • nervous system phenotype
  • abnormal myelin sheath morphology
    • in 2-month old mice, myelin sheaths are significantly thinner in optic nerves compared to wild-type controls   (MGI Ref ID J:116162)
    • more axons in sciatic nerve of mutants appear smaller in diameter than in wild-type   (MGI Ref ID J:116162)
  • abnormal myelination
    • hypomyelination is observed in hippocampus and cerebral cortex at P15 and P30, but axonal development is normal   (MGI Ref ID J:116162)
    • sciatic nerve is hypomyelinated in mutants   (MGI Ref ID J:116162)
  • integument phenotype
  • decreased thermal nociceptive threshold
    • mutants retract paws from thermal stimulus more rapidly than wild-type controls, indicating greater pain sensitivity   (MGI Ref ID J:116162)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Neurobiology Research
Alzheimer's Disease
      Bace mutants

Bace1tm1Pcw related

Neurobiology Research
Alzheimer's Disease

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Bace1tm1Pcw
Allele Name targeted mutation 1, Philip C Wong
Allele Type Targeted (knock-out)
Common Name(s) BACE1-;
Mutation Made By Philip Wong,   Johns Hopkins University
Strain of Origin(129X1/SvJ x 129S1/Sv)F1-Kitl<+>
ES Cell Line NameR1
ES Cell Line Strain(129X1/SvJ x 129S1/Sv)F1-Kitl<+>
Gene Symbol and Name Bace1, beta-site APP cleaving enzyme 1
Chromosome 9
Gene Common Name(s) ASP2; BACE; C76936; HSPC104; expressed sequence C76936;
Molecular Note Exon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. Normal protein was undetected by Western blot analysis of homozygous mutant embryos. [MGI Ref ID J:79847]

Genotyping

Genotyping Information

Genotyping Protocols

Bacetm1Pcw, Melt Curve Analysis
Bace1tm1Pcw, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Cai H; Wang Y; McCarthy D; Wen H; Borchelt DR; Price DL; Wong PC. 2001. BACE1 is the major beta-secretase for generation of Abeta peptides by neurons. Nat Neurosci 4(3):233-4. [PubMed: 11224536]  [MGI Ref ID J:79847]

Additional References

Bace1tm1Pcw related

Bhattacharyya R; Barren C; Kovacs DM. 2013. Palmitoylation of amyloid precursor protein regulates amyloidogenic processing in lipid rafts. J Neurosci 33(27):11169-83. [PubMed: 23825420]  [MGI Ref ID J:199824]

Cao L; Rickenbacher GT; Rodriguez S; Moulia TW; Albers MW. 2012. The precision of axon targeting of mouse olfactory sensory neurons requires the BACE1 protease. Sci Rep 2:231. [PubMed: 22355745]  [MGI Ref ID J:207280]

Cui S; Xiong F; Hong Y; Jung JU; Li XS; Liu JZ; Yan R; Mei L; Feng X; Xiong WC. 2011. APPswe/Abeta regulation of osteoclast activation and RAGE expression in an age-dependent manner. J Bone Miner Res 26(5):1084-98. [PubMed: 21542009]  [MGI Ref ID J:184350]

Devi L; Ohno M. 2010. Genetic reductions of beta-site amyloid precursor protein-cleaving enzyme 1 and amyloid-beta ameliorate impairment of conditioned taste aversion memory in 5XFAD Alzheimer's disease model mice. Eur J Neurosci 31(1):110-8. [PubMed: 20092558]  [MGI Ref ID J:158363]

Devi L; Ohno M. 2012. Mitochondrial dysfunction and accumulation of the beta-secretase-cleaved C-terminal fragment of APP in Alzheimer's disease transgenic mice. Neurobiol Dis 45(1):417-24. [PubMed: 21933711]  [MGI Ref ID J:179837]

Devi L; Ohno M. 2010. Phospho-eIF2alpha level is important for determining abilities of BACE1 reduction to rescue cholinergic neurodegeneration and memory defects in 5XFAD mice. PLoS One 5(9):e12974. [PubMed: 20886088]  [MGI Ref ID J:165103]

Esterhazy D; Stutzer I; Wang H; Rechsteiner MP; Beauchamp J; Dobeli H; Hilpert H; Matile H; Prummer M; Schmidt A; Lieske N; Boehm B; Marselli L; Bosco D; Kerr-Conte J; Aebersold R; Spinas GA; Moch H; Migliorini C; Stoffel M. 2011. Bace2 Is a beta Cell-Enriched Protease that Regulates Pancreatic beta Cell Function and Mass. Cell Metab 14(3):365-77. [PubMed: 21907142]  [MGI Ref ID J:176653]

Farah MH; Pan BH; Hoffman PN; Ferraris D; Tsukamoto T; Nguyen T; Wong PC; Price DL; Slusher BS; Griffin JW. 2011. Reduced BACE1 Activity Enhances Clearance of Myelin Debris and Regeneration of Axons in the Injured Peripheral Nervous System. J Neurosci 31(15):5744-54. [PubMed: 21490216]  [MGI Ref ID J:170970]

Giusti-Rodriguez P; Gao J; Graff J; Rei D; Soda T; Tsai LH. 2011. Synaptic Deficits Are Rescued in the p25/Cdk5 Model of Neurodegeneration by the Reduction of beta-Secretase (BACE1). J Neurosci 31(44):15751-6. [PubMed: 22049418]  [MGI Ref ID J:177847]

Hitt B; Riordan SM; Kukreja L; Eimer WA; Rajapaksha TW; Vassar R. 2012. beta-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1)-deficient mice exhibit a close homolog of L1 (CHL1) loss-of-function phenotype involving axon guidance defects. J Biol Chem 287(46):38408-25. [PubMed: 22988240]  [MGI Ref ID J:192472]

Hitt BD; Jaramillo TC; Chetkovich DM; Vassar R. 2010. BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization. Mol Neurodegener 5:31. [PubMed: 20731874]  [MGI Ref ID J:163907]

Hu X; He W; Diaconu C; Tang X; Kidd GJ; Macklin WB; Trapp BD; Yan R. 2008. Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves. FASEB J 22(8):2970-80. [PubMed: 18413858]  [MGI Ref ID J:137970]

Hu X; He W; Luo X; Tsubota KE; Yan R. 2013. BACE1 regulates hippocampal astrogenesis via the Jagged1-Notch pathway. Cell Rep 4(1):40-9. [PubMed: 23831026]  [MGI Ref ID J:200998]

Hu X; Hicks CW; He W; Wong P; Macklin WB; Trapp BD; Yan R. 2006. Bace1 modulates myelination in the central and peripheral nervous system. Nat Neurosci 9(12):1520-5. [PubMed: 17099708]  [MGI Ref ID J:116162]

Hu X; Schlanger R; He W; Macklin WB; Yan R. 2013. Reversing hypomyelination in BACE1-null mice with Akt-DD overexpression. FASEB J 27(5):1868-73. [PubMed: 23335052]  [MGI Ref ID J:197749]

Hu X; Zhou X; He W; Yang J; Xiong W; Wong P; Wilson CG; Yan R. 2010. BACE1 deficiency causes altered neuronal activity and neurodegeneration. J Neurosci 30(26):8819-29. [PubMed: 20592204]  [MGI Ref ID J:161845]

Kim DY; Gersbacher MT; Inquimbert P; Kovacs DM. 2011. Reduced sodium channel Na(v)1.1 levels in BACE1-null mice. J Biol Chem 286(10):8106-16. [PubMed: 21190943]  [MGI Ref ID J:170564]

Koike MA; Lin AJ; Pham J; Nguyen E; Yeh JJ; Rahimian R; Tromberg BJ; Choi B; Green KN; LaFerla FM. 2012. APP knockout mice experience acute mortality as the result of ischemia. PLoS One 7(8):e42665. [PubMed: 22912719]  [MGI Ref ID J:189875]

Kuhn PH; Koroniak K; Hogl S; Colombo A; Zeitschel U; Willem M; Volbracht C; Schepers U; Imhof A; Hoffmeister A; Haass C; Rossner S; Brase S; Lichtenthaler SF. 2012. Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons. EMBO J 31(14):3157-68. [PubMed: 22728825]  [MGI Ref ID J:186413]

Laird FM; Cai H; Savonenko AV; Farah MH; He K; Melnikova T; Wen H; Chiang HC; Xu G; Koliatsos VE; Borchelt DR; Price DL; Lee HK; Wong PC. 2005. BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions. J Neurosci 25(50):11693-709. [PubMed: 16354928]  [MGI Ref ID J:123534]

Liang X; Wang Q; Hand T; Wu L; Breyer RM; Montine TJ; Andreasson K. 2005. Deletion of the prostaglandin E2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer's disease. J Neurosci 25(44):10180-7. [PubMed: 16267225]  [MGI Ref ID J:102728]

Loane DJ; Pocivavsek A; Moussa CE; Thompson R; Matsuoka Y; Faden AI; Rebeck GW; Burns MP. 2009. Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury. Nat Med 15(4):377-9. [PubMed: 19287391]  [MGI Ref ID J:149374]

Philipson O; Lannfelt L; Nilsson LN. 2009. Genetic and pharmacological evidence of intraneuronal Abeta accumulation in APP transgenic mice. FEBS Lett 583(18):3021-6. [PubMed: 19683527]  [MGI Ref ID J:152969]

Savonenko AV; Melnikova T; Laird FM; Stewart KA; Price DL; Wong PC. 2008. Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice. Proc Natl Acad Sci U S A 105(14):5585-90. [PubMed: 18385378]  [MGI Ref ID J:133643]

Seshadri S; Kamiya A; Yokota Y; Prikulis I; Kano S; Hayashi-Takagi A; Stanco A; Eom TY; Rao S; Ishizuka K; Wong P; Korth C; Anton ES; Sawa A. 2010. Disrupted-in-Schizophrenia-1 expression is regulated by beta-site amyloid precursor protein cleaving enzyme-1-neuregulin cascade. Proc Natl Acad Sci U S A 107(12):5622-7. [PubMed: 20212127]  [MGI Ref ID J:158688]

Varvel NH; Bhaskar K; Kounnas MZ; Wagner SL; Yang Y; Lamb BT; Herrup K. 2009. NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease. J Clin Invest 119(12):3692-702. [PubMed: 19907078]  [MGI Ref ID J:155100]

Varvel NH; Bhaskar K; Patil AR; Pimplikar SW; Herrup K; Lamb BT. 2008. Abeta oligomers induce neuronal cell cycle events in Alzheimer's disease. J Neurosci 28(43):10786-93. [PubMed: 18945886]  [MGI Ref ID J:144634]

Wang H; Song L; Laird F; Wong PC; Lee HK. 2008. BACE1 knock-outs display deficits in activity-dependent potentiation of synaptic transmission at mossy fiber to CA3 synapses in the hippocampus. J Neurosci 28(35):8677-81. [PubMed: 18753368]  [MGI Ref ID J:138795]

Winton MJ; Lee EB; Sun E; Wong MM; Leight S; Zhang B; Trojanowski JQ; Lee VM. 2011. Intraneuronal APP, Not Free A{beta} Peptides in 3xTg-AD Mice: Implications for Tau versus A{beta}-Mediated Alzheimer Neurodegeneration. J Neurosci 31(21):7691-9. [PubMed: 21613482]  [MGI Ref ID J:173328]

Zhang XM; Cai Y; Xiong K; Cai H; Luo XG; Feng JC; Clough RW; Struble RG; Patrylo PR; Yan XX. 2009. Beta-secretase-1 elevation in transgenic mouse models of Alzheimer's disease is associated with synaptic/axonal pathology and amyloidogenesis: implications for neuritic plaque development. Eur J Neurosci 30(12):2271-83. [PubMed: 20092570]  [MGI Ref ID J:157228]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX11

Colony Maintenance

Breeding & HusbandryThe strain is currently maintained by intercrossing homozygotes. Homozygotes of this strain are noticeably smaller than heterozygous or wildtype littermates.
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $195.00Female or MaleHomozygous for Bace1tm1Pcw  
Price per Pair (US dollars $)Pair Genotype
$390.00Homozygous for Bace1tm1Pcw x Homozygous for Bace1tm1Pcw  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $253.50Female or MaleHomozygous for Bace1tm1Pcw  
Price per Pair (US dollars $)Pair Genotype
$507.00Homozygous for Bace1tm1Pcw x Homozygous for Bace1tm1Pcw  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
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JAX® Services
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Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
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Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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