Strain Name:

B6.129P2-Esr1tm1Ksk/J

Stock Number:

004744

Availability:

Repository- Live

Use Restrictions Apply, see Purchasing Information

Description

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Mating SystemHeterozygote x Heterozygote         (Female x Male)
Specieslaboratory mouse
GenerationN10F?+F9 (05-DEC-07)
 
Donating Investigator Kenneth Korach,   LRDT, NIEHS, NIH

Description
At birth, mice homozygous for the targeted allele are viable and normal in size and appearence. Female mice exhibit ovaries that lack corpora lutea and hypoplastic uteri that are unresponsive to estrogen. In males, below normal testis weight is associated with a diminished sperm count (10% of normal). Homozygous females are infertile. The fertility of homozygous males is greatly reduced, but not abolished.

Development
A targeting vector containing a neomycin resistance gene driven by the mouse phosphoglycerate kinase promoter was used to disrupt the second exon of the targeted gene. A herpes simplex virus thymidine kinase was used for negative selection. The construct was electroporated into 129P2/OlaHsd-derived E14TG2a embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6 blastocysts. Correctly targeted ES cells were injected into C57BL/6J blastocysts to obtain chimeric animals.

Control Information

  Allele   Control
 Esr1tm1Ksk  Wild-type from the colony
 
  Considerations for Choosing Controls

Related Strains

View Strains carrying other alleles of Esr1     (11 strains)

Additional Web Information

Congenic Nomenclature

Phenotype

Phenotype Information

Mammalian Phenotype Terms assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Esr1tm1Ksk/Esr1tm1Ksk

        involves: 129P2/OlaHsd * C57BL/6J
  • behavior/neurological phenotype
  • abnormal maternal nurturing (MGI Ref ID J:51468)
    • abnormal pup retrieval (MGI Ref ID J:51468)
      • noninfanticidal female mutants displayed reduced levels of retrieving behavior
    • pup cannibalization (MGI Ref ID J:51468)
      • about 40% of mutant females displayed infanticidal behavior
  • abnormal sexual interaction (MGI Ref ID J:36658)
    • abnormal mating receptivity (MGI Ref ID J:51468)
      • females showed decreased lordosis response
  • increased aggression towards females (MGI Ref ID J:51468)
    • females showed increased aggression toward female intruders
  • reproductive system phenotype
  • abnormal ovary morphology (MGI Ref ID J:16338)
    • containing few granulosa cells
    • abnormal ovarian follicle morphology (MGI Ref ID J:16338)
    • absent corpus luteum (MGI Ref ID J:16338)
    • ovarian cysts (MGI Ref ID J:16338)
      • hemorrhagic ovarian cysts
  • abnormal seminiferous tubule morphology (MGI Ref ID J:36658)
    • tubules are either dilated with disorganized epithelia or lack a lumen and contain mostly sertoli cells
    • seminiferous tubule degeneration (MGI Ref ID J:36658)
      • beginning at 10 to 12 weeks of age
  • abnormal spermatogenesis (MGI Ref ID J:36658)
    • disruption of spermatogenesis evident at 10 weeks of age
    • oligozoospermia (MGI Ref ID J:16338)
      • sperm count was 10% that of wild-type
      • reduced concentration of epididymal sperm at 10 weeks of age
  • asthenozoospermia (MGI Ref ID J:36658)
  • female infertility (MGI Ref ID J:16338)
  • male infertility (MGI Ref ID J:36658)
  • reduced male fertility (MGI Ref ID J:16338)
    • 3 of 15 males sired offspring
  • small testis (MGI Ref ID J:16338)
  • uterine hypoplasia (MGI Ref ID J:16338)
  • endocrine/exocrine gland phenotype
  • abnormal ovary morphology (MGI Ref ID J:16338)
    • containing few granulosa cells
    • abnormal ovarian follicle morphology (MGI Ref ID J:16338)
    • absent corpus luteum (MGI Ref ID J:16338)
    • ovarian cysts (MGI Ref ID J:16338)
      • hemorrhagic ovarian cysts
  • abnormal seminiferous tubule morphology (MGI Ref ID J:36658)
    • tubules are either dilated with disorganized epithelia or lack a lumen and contain mostly sertoli cells
    • seminiferous tubule degeneration (MGI Ref ID J:36658)
      • beginning at 10 to 12 weeks of age
  • small testis (MGI Ref ID J:16338)

Esr1tm1Ksk/Esr1tm1Ksk

        Background Not Specified
  • endocrine/exocrine gland phenotype
  • abnormal efferent ductules of testis (MGI Ref ID J:83231)
    • dilated efferent ductultes
  • small testis (MGI Ref ID J:83231)
    • a transient increase in testicular weight due to accumulation of testicular secretions is followed by atrophy and weight loss by 185 days of age
  • reproductive system phenotype
  • abnormal efferent ductules of testis (MGI Ref ID J:83231)
    • dilated efferent ductultes
  • abnormal epididymis morphology (MGI Ref ID J:60490)
    • luminal areas more than twice the size of those of wild-type
  • oligozoospermia (MGI Ref ID J:83231)
    • sperm was diluted rather than concentrated in the epididymis
  • small testis (MGI Ref ID J:83231)
    • a transient increase in testicular weight due to accumulation of testicular secretions is followed by atrophy and weight loss by 185 days of age

Esr1tm1Ksk/Esr1tm1Ksk

        involves: C57BL/6J
  • behavior/neurological phenotype
  • abnormal sexual interaction (MGI Ref ID J:38600)
    • males mounted females but made fewer intromissions
  • decreased aggression (MGI Ref ID J:38600)
    • male mice showed a decrease in aggressive behavior relative to wild-type
  • hyperactivity (MGI Ref ID J:38600)
    • male mice exhibited female-type open field behavior including increased activity
  • increased vertical activity (MGI Ref ID J:38600)
    • male mice exhibited female-type open field behavior including increased rearing
  • reproductive system phenotype
  • abnormal ejaculation (MGI Ref ID J:38600)

Esr1tm1Ksk/Esr1tm1Ksk

        involves: 129P2/OlaHsd
  • reproductive system phenotype
  • abnormal efferent ductules of testis (MGI Ref ID J:125658)
    • ductules dilated compared to wild-type
  • abnormal seminiferous tubule morphology (MGI Ref ID J:125658)
    • rete testes dilated compared to wild-type
  • male infertility (MGI Ref ID J:125658)
    • males are sterile
  • endocrine/exocrine gland phenotype
  • abnormal efferent ductules of testis (MGI Ref ID J:125658)
    • ductules dilated compared to wild-type
  • abnormal seminiferous tubule morphology (MGI Ref ID J:125658)
    • rete testes dilated compared to wild-type

Research Applications

This mouse can be used to support research in many areas including:

Neurobiology Research
Parkinson's Disease (increased vulnerability to MPTP)

Esr1tm1Ksk related

Developmental Biology Research
Internal/Organ Defects (ovary; uterus)

Internal/Organ Research
Other Organ Defects

Reproductive Biology Research
Developmental Defects Affecting Gonads (germ cell deficient)
Fertility Defects

Genes & Alleles

Gene & Allele Information

Allele Symbol Esr1tm1Ksk
Allele Name targeted mutation 1, Kenneth S Korach
Common Name(s) ER1KO; ERKO; ERalpha-; ERalphaKO; ERalphaKOCH; Esr1tm1Unc; alpha-ERKO; alphaERKO;
Mutation Made By Kenneth Korach,   LRDT, NIEHS, NIH
Strain of Origin129P2/OlaHsd
ES Cell Line NameE14TG2a
ES Cell Line Strain129P2/OlaHsd
Gene Symbol and Name Esr1, estrogen receptor 1 (alpha)
Chromosome 10
Gene Common Name(s) AA420328; AU041214; DKFZp686N23123; ER; ER-alpha; ER[a]; ERa; ERalpha; ESR; ESRA; Estr; Estra; NR3A1; RNESTROR; estrogen receptor; estrogen receptor alpha; expressed sequence AA420328; expressed sequence AU041214;
Molecular Note Insertion of a PGK-neomycin resistance cassette into exon 2 disrupted the reading frame downstream of the ATG start site. ELISA studies using antibodies to the carboxy terminus detected low concentrations of endogenous protein in uterine tissue from homozygous mutant mice. [MGI Ref ID J:16338]

Genotyping

Genotyping Information

Genotyping Protocols

Esr1tm1Ksk, SEP PCR, vers. 4

Helpful Links

Optimizing PCR Protocols

References

References

Selected Reference(s)

Lubahn DB; Moyer JS; Golding TS; Couse JF; Korach KS; Smithies O. 1993. Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene. Proc Natl Acad Sci U S A 90(23):11162-6. [PubMed: 8248223]  [MGI Ref ID J:16338]

Additional References

Esr1tm1Ksk related

Abraham IM; Todman MG; Korach KS; Herbison AE. 2004. Critical in vivo roles for classical estrogen receptors in rapid estrogen actions on intracellular signaling in mouse brain. Endocrinology 145(7):3055-61. [PubMed: 14976146]  [MGI Ref ID J:105631]

Akingbemi BT; Ge R; Rosenfeld CS; Newton LG; Hardy DO; Catterall JF; Lubahn DB; Korach KS; Hardy MP. 2003. Estrogen receptor-alpha gene deficiency enhances androgen biosynthesis in the mouse Leydig cell. Endocrinology 144(1):84-93. [PubMed: 12488333]  [MGI Ref ID J:115529]

Allred KF; Smart EJ; Wilson ME. 2006. Estrogen receptor-alpha mediates gender differences in atherosclerosis induced by HIV protease inhibitors. J Biol Chem 281(3):1419-25. [PubMed: 16299001]  [MGI Ref ID J:107322]

Alves SE; McEwen BS; Hayashi S; Korach KS; Pfaff DW; Ogawa S. 2000. Estrogen-regulated progestin receptors are found in the midbrain raphe but not hippocampus of estrogen receptor alpha (ERalpha) gene-disrupted mice J Comp Neurol 427(2):185-95. [PubMed: 11054687]  [MGI Ref ID J:65530]

Barros RP; Machado UF; Warner M; Gustafsson JA. 2006. Muscle GLUT4 regulation by estrogen receptors ERbeta and ERalpha. Proc Natl Acad Sci U S A 103(5):1605-8. [PubMed: 16423895]  [MGI Ref ID J:105982]

Bocchinfuso WP; Hively WP; Couse JF; Varmus HE; Korach KS. 1999. A mouse mammary tumor virus-Wnt-1 transgene induces mammary gland hyperplasia and tumorigenesis in mice lacking estrogen receptor-alpha. Cancer Res 59(8):1869-76. [PubMed: 10213494]  [MGI Ref ID J:54215]

Bocchinfuso WP; Korach KS. 1997. Mammary gland development and tumorigenesis in estrogen receptor knockout mice. J Mammary Gland Biol Neoplasia 2(4):323-34. [PubMed: 10935020]  [MGI Ref ID J:64643]

Bocchinfuso WP; Lindzey JK; Hewitt SC; Clark JA; Myers PH; Cooper R; Korach KS. 2000. Induction of mammary gland development in estrogen receptor-alpha knockout mice. Endocrinology 141(8):2982-94. [PubMed: 10919287]  [MGI Ref ID J:64639]

Borzychowski AM; Chantakru S; Minhas K; Paffaro VA; Yamada AT; He H; Korach KS; Croy BA. 2003. Functional analysis of murine uterine natural killer cells genetically devoid of oestrogen receptors. Placenta 24(4):403-11. [PubMed: 12657515]  [MGI Ref ID J:117832]

Bryzgalova G; Gao H; Ahren B; Zierath JR; Galuska D; Steiler TL; Dahlman-Wright K; Nilsson S; Gustafsson JA; Efendic S; Khan A. 2006. Evidence that oestrogen receptor-alpha plays an important role in the regulation of glucose homeostasis in mice: insulin sensitivity in the liver. Diabetologia 49(3):588-97. [PubMed: 16463047]  [MGI Ref ID J:107888]

Buchanan DL; Kurita T; Taylor JA; Lubahn DB; Cunha GR; Cooke PS. 1998. Role of stromal and epithelial estrogen receptors in vaginal epithelial proliferation, stratification, and cornification. Endocrinology 139(10):4345-52. [PubMed: 9751518]  [MGI Ref ID J:108803]

Burns KH; Agno JE; Chen L; Haupt B; Ogbonna SC; Korach KS; Matzuk MM. 2003. Sexually dimorphic roles of steroid hormone receptor signaling in gonadal tumorigenesis. Mol Endocrinol 17(10):2039-52. [PubMed: 12855748]  [MGI Ref ID J:84989]

Carey MA; Card JW; Bradbury JA; Moorman MP; Haykal-Coates N; Gavett SH; Graves JP; Walker VR; Flake GP; Voltz JW; Zhu D; Jacobs ER; Dakhama A; Larsen GL; Loader JE; Gelfand EW; Germolec DR; Korach KS; Zeldin DC. 2007. Spontaneous airway hyperresponsiveness in estrogen receptor-alpha-deficient mice. Am J Respir Crit Care Med 175(2):126-35. [PubMed: 17095746]  [MGI Ref ID J:135930]

Carreras E; Turner S; Paharkova-Vatchkova V; Mao A; Dascher C; Kovats S. 2008. Estradiol acts directly on bone marrow myeloid progenitors to differentially regulate GM-CSF or Flt3 ligand-mediated dendritic cell differentiation. J Immunol 180(2):727-38. [PubMed: 18178810]  [MGI Ref ID J:130951]

Chagin AS; Lindberg MK; Andersson N; Moverare S; Gustafsson JA; Savendahl L; Ohlsson C. 2004. Estrogen receptor-beta inhibits skeletal growth and has the capacity to mediate growth plate fusion in female mice. J Bone Miner Res 19(1):72-7. [PubMed: 14753739]  [MGI Ref ID J:111108]

Choleris E; Gustafsson JA; Korach KS; Muglia LJ; Pfaff DW; Ogawa S. 2003. An estrogen-dependent four-gene micronet regulating social recognition: a study with oxytocin and estrogen receptor-alpha and -beta knockout mice. Proc Natl Acad Sci U S A 100(10):6192-7. [PubMed: 12730370]  [MGI Ref ID J:83406]

Choleris E; Ogawa S; Kavaliers M; Gustafsson JA; Korach KS; Muglia LJ; Pfaff DW. 2006. Involvement of estrogen receptor alpha, beta and oxytocin in social discrimination: A detailed behavioral analysis with knockout female mice. Genes Brain Behav 5(7):528-39. [PubMed: 17010099]  [MGI Ref ID J:126499]

Chou YC; Uehara N; Lowry JR; Shyamala G. 2003. Mammary epithelial cells of PR-A transgenic mice exhibit distinct alterations in gene expression and growth potential associated with transformation. Carcinogenesis 24(3):403-9. [PubMed: 12663498]  [MGI Ref ID J:82840]

Corbacho AM; Eiserich JP; Zuniga LA; Valacchi G; Villablanca AC. 2007. Compromised aortic vasoreactivity in male estrogen receptor-alpha-deficient mice during acute lipopolysaccharide-induced inflammation. Endocrinology 148(3):1403-11. [PubMed: 17158209]  [MGI Ref ID J:129588]

Couse JF; Bunch DO; Lindzey J; Schomberg DW; Korach KS. 1999. Prevention of the polycystic ovarian phenotype and characterization of ovulatory capacity in the estrogen receptor-alpha knockout mouse. Endocrinology 140(12):5855-65. [PubMed: 10579351]  [MGI Ref ID J:58578]

Couse JF; Curtis Hewitt S; Korach KS. 2000. Receptor null mice reveal contrasting roles for estrogen receptor alpha and beta in reproductive tissues. J Steroid Biochem Mol Biol 74(5):287-96. [PubMed: 11162937]  [MGI Ref ID J:66741]

Couse JF; Curtis SW; Washburn TF; Eddy EM; Schomberg DW; Korach KS. 1995. Disruption of the mouse oestrogen receptor gene: resulting phenotypes and experimental findings. Biochem Soc Trans 23(4):929-35. [PubMed: 8654869]  [MGI Ref ID J:31065]

Couse JF; Curtis SW; Washburn TF; Lindzey J; Golding TS; Lubahn DB; Smithies O; Korach KS. 1995. Analysis of transcription and estrogen insensitivity in the female mouse after targeted disruption of the estrogen receptor gene. Mol Endocrinol 9(11):1441-54. [PubMed: 8584021]  [MGI Ref ID J:112080]

Couse JF; Dixon D; Yates M; Moore AB; Ma L; Maas R; Korach KS. 2001. Estrogen receptor-alpha knockout mice exhibit resistance to the developmental effects of neonatal diethylstilbestrol exposure on the female reproductive tract. Dev Biol 238(2):224-38. [PubMed: 11784006]  [MGI Ref ID J:72221]

Couse JF; Hewitt SC; Bunch DO; Sar M; Walker VR; Davis BJ; Korach KS. 1999. Postnatal sex reversal of the ovaries in mice lacking estrogen receptors alpha and beta. Science 286(5448):2328-31. [PubMed: 10600740]  [MGI Ref ID J:59105]

Couse JF; Korach KS. 1999. Reproductive phenotypes in the estrogen receptor-alpha knockout mouse. Ann Endocrinol (Paris) 60(2):143-8. [PubMed: 10456188]  [MGI Ref ID J:57398]

Couse JF; Lindzey J; Grandien K; Gustafsson JA; Korach KS. 1997. Tissue distribution and quantitative analysis of estrogen receptor-alpha (ERalpha) and estrogen receptor-beta (ERbeta) messenger ribonucleic acid in the wild-type and ERalpha-knockout mouse. Endocrinology 138(11):4613-21. [PubMed: 9348186]  [MGI Ref ID J:43861]

Couse JF; Yates MM; Deroo BJ; Korach KS. 2005. Estrogen receptor-beta is critical to granulosa cell differentiation and the ovulatory response to gonadotropins. Endocrinology 146(8):3247-62. [PubMed: 15831568]  [MGI Ref ID J:129823]

Couse JF; Yates MM; Rodriguez KF; Johnson JA; Poirier D; Korach KS. 2006. The intraovarian actions of estrogen receptor-alpha are necessary to repress the formation of morphological and functional Leydig-like cells in the female gonad. Endocrinology 147(8):3666-78. [PubMed: 16627580]  [MGI Ref ID J:111680]

Couse JF; Yates MM; Sanford R; Nyska A; Nilson JH; Korach KS. 2004. Formation of cystic ovarian follicles associated with elevated luteinizing hormone requires estrogen receptor-beta. Endocrinology 145(10):4693-702. [PubMed: 15231698]  [MGI Ref ID J:92628]

Couse JF; Yates MM; Walker VR; Korach KS. 2003. Characterization of the hypothalamic-pituitary-gonadal axis in estrogen receptor (ER) Null mice reveals hypergonadism and endocrine sex reversal in females lacking ERalpha but not ERbeta. Mol Endocrinol 17(6):1039-53. [PubMed: 12624116]  [MGI Ref ID J:83626]

Curran EM; Berghaus LJ; Vernetti NJ; Saporita AJ; Lubahn DB; Estes DM. 2001. Natural killer cells express estrogen receptor-alpha and estrogen receptor-beta and can respond to estrogen via a non-estrogen receptor-alpha-mediated pathway. Cell Immunol 214(1):12-20. [PubMed: 11902825]  [MGI Ref ID J:115367]

Curran EM; Judy BM; Newton LG; Lubahn DB; Rottinghaus GE; Macdonald RS; Franklin C; Estes DM. 2004. Dietary soy phytoestrogens and ERalpha signalling modulate interferon gamma production in response to bacterial infection. Clin Exp Immunol 135(2):219-25. [PubMed: 14738448]  [MGI Ref ID J:88475]

Curtis Hewitt S; Goulding EH; Eddy EM; Korach KS. 2002. Studies using the estrogen receptor alpha knockout uterus demonstrate that implantation but not decidualization-associated signaling is estrogen dependent. Biol Reprod 67(4):1268-77. [PubMed: 12297545]  [MGI Ref ID J:108638]

Curtis SW; Clark J; Myers P; Korach KS. 1999. Disruption of estrogen signaling does not prevent progesterone action in the estrogen receptor alpha knockout mouse uterus. Proc Natl Acad Sci U S A 96(7):3646-51. [PubMed: 10097091]  [MGI Ref ID J:54077]

Curtis SW; Washburn T; Sewall C; DiAugustine R; Lindzey J; Couse JF; Korach KS. 1996. Physiological coupling of growth factor and steroid receptor signaling pathways: estrogen receptor knockout mice lack estrogen-like response to epidermal growth factor. Proc Natl Acad Sci U S A 93(22):12626-30. [PubMed: 8901633]  [MGI Ref ID J:36257]

Day JK; Besch-Williford C; McMann TR; Hufford MG; Lubahn DB; MacDonald RS. 2001. Dietary genistein increased DMBA-induced mammary adenocarcinoma in wild-type, but not ER alpha KO, mice. Nutr Cancer 39(2):226-32. [PubMed: 11759285]  [MGI Ref ID J:73536]

Dellovade TL; Merchenthaler I. 2004. Estrogen regulation of neurokinin B gene expression in the mouse arcuate nucleus is mediated by estrogen receptor alpha. Endocrinology 145(2):736-42. [PubMed: 14592957]  [MGI Ref ID J:105513]

Dominguez-Salazar E; Bateman HL; Rissman EF. 2004. Background matters: the effects of estrogen receptor alpha gene disruption on male sexual behavior are modified by background strain. Horm Behav 46(4):482-90. [PubMed: 15465535]  [MGI Ref ID J:101958]

Donaldson KM; Tong SY; Washburn T; Lubahn DB; Eddy EM; Hutson JM; Korach KS. 1996. Morphometric study of the gubernaculum in male estrogen receptor mutant mice. J Androl 17(2):91-5. [PubMed: 8723431]  [MGI Ref ID J:112350]

Dupont S; Dennefeld C; Krust A; Chambon P; Mark M. 2003. Expression of Sox9 in granulosa cells lacking the estrogen receptors, ERalpha and ERbeta. Dev Dyn 226(1):103-6. [PubMed: 12508230]  [MGI Ref ID J:107788]

Eddy EM; Washburn TF; Bunch DO; Goulding EH; Gladen BC; Lubahn DB; Korach KS. 1996. Targeted disruption of the estrogen receptor gene in male mice causes alteration of spermatogenesis and infertility. Endocrinology 137(11):4796-805. [PubMed: 8895349]  [MGI Ref ID J:36658]

Emmen JM; Couse JF; Elmore SA; Yates MM; Kissling GE; Korach KS. 2005. In vitro growth and ovulation of follicles from ovaries of estrogen receptor (ER){alpha} and ER{beta} null mice indicate a role for ER{beta} in follicular maturation. Endocrinology 146(6):2817-26. [PubMed: 15731357]  [MGI Ref ID J:109466]

Erlandsson MC; Jonsson CA; Islander U; Ohlsson C; Carlsten H. 2003. Oestrogen receptor specificity in oestradiol-mediated effects on B lymphopoiesis and immunoglobulin production in male mice. Immunology 108(3):346-51. [PubMed: 12603601]  [MGI Ref ID J:82423]

Erlandsson MC; Ohlsson C; Gustafsson JA; Carlsten H. 2001. Role of oestrogen receptors alpha and beta in immune organ development and in oestrogen-mediated effects on thymus. Immunology 103(1):17-25. [PubMed: 11380688]  [MGI Ref ID J:110416]

Fugger HN; Foster TC; Gustafsson J; Rissman EF. 2000. Novel effects of estradiol and estrogen receptor alpha and beta on cognitive function(1) Brain Res 883(2):258-64. [PubMed: 11074057]  [MGI Ref ID J:65785]

Gabel SA; Walker VR; London RE; Steenbergen C; Korach KS; Murphy E. 2005. Estrogen receptor beta mediates gender differences in ischemia/reperfusion injury. J Mol Cell Cardiol 38(2):289-97. [PubMed: 15698835]  [MGI Ref ID J:101968]

Geary N; Asarian L; Korach KS; Pfaff DW; Ogawa S. 2001. Deficits in e2-dependent control of feeding, weight gain, and cholecystokinin satiation in er-alpha null mice. Endocrinology 142(11):4751-7. [PubMed: 11606440]  [MGI Ref ID J:72792]

Ghosh D; Taylor JA; Green JA; Lubahn DB. 1999. Methoxychlor stimulates estrogen-responsive messenger ribonucleic acids in mouse uterus through a non-estrogen receptor (non-ER) alpha and non-ER beta mechanism. Endocrinology 140(8):3526-33. [PubMed: 10433208]  [MGI Ref ID J:56920]

Gore AC; Wersinger SR; Rissman EF. 2000. Effects of female pheromones on gonadotropin-releasing hormone gene expression and luteinizing hormone release in male wild-type and oestrogen receptor-alpha knockout mice. J Neuroendocrinol 12(12):1200-4. [PubMed: 11106978]  [MGI Ref ID J:103676]

Gould ML; Hurst PR; Nicholson HD. 2007. The effects of oestrogen receptors {alpha} and {beta} on testicular cell number and steroidogenesis in mice. Reproduction 134(2):271-9. [PubMed: 17660237]  [MGI Ref ID J:123340]

Goyal HO; Braden TD; Cooke PS; Szewczykowski MA; Williams CS; Dalvi P; Williams JW. 2007. Estrogen receptor-{alpha} mediates estrogen-inducible abnormalities in the developing penis. Reproduction 133(5):1057-67. [PubMed: 17616734]  [MGI Ref ID J:122840]

Grummer R; Hewitt SW; Traub O; Korach KS; Winterhager E. 2004. Different regulatory pathways of endometrial connexin expression: preimplantation hormonal-mediated pathway versus embryo implantation-initiated pathway. Biol Reprod 71(1):273-81. [PubMed: 15028626]  [MGI Ref ID J:108494]

Gu Q; Korach KS; Moss RL. 1999. Rapid action of 17beta-estradiol on kainate-induced currents in hippocampal neurons lacking intracellular estrogen receptors. Endocrinology 140(2):660-6. [PubMed: 9927291]  [MGI Ref ID J:52901]

Heine PA; Taylor JA; Iwamoto GA; Lubahn DB; Cooke PS. 2000. Increased adipose tissue in male and female estrogen receptor-alpha knockout mice Proc Natl Acad Sci U S A 97(23):12729-34. [PubMed: 11070086]  [MGI Ref ID J:65806]

Hess RA; Bunick D; Lee KH; Bahr J; Taylor JA; Korach KS; Lubahn DB. 1997. A role for oestrogens in the male reproductive system. Nature 390(6659):509-12. [PubMed: 9393999]  [MGI Ref ID J:83231]

Hess RA; Bunick D; Lubahn DB; Zhou Q; Bouma J. 2000. Morphologic changes in efferent ductules and epididymis in estrogen receptor-alpha knockout mice. J Androl 21(1):107-21. [PubMed: 10670526]  [MGI Ref ID J:60490]

Hewitt SC; Bocchinfuso WP; Zhai J; Harrell C; Koonce L; Clark J; Myers P; Korach KS. 2002. Lack of ductal development in the absence of functional estrogen receptor alpha delays mammary tumor formation induced by transgenic expression of ErbB2/neu. Cancer Res 62(10):2798-805. [PubMed: 12019156]  [MGI Ref ID J:76653]

Hewitt SC; Korach KS. 2003. Oestrogen receptor knockout mice: roles for oestrogen receptors alpha and beta in reproductive tissues. Reproduction 125(2):143-9. [PubMed: 12578528]  [MGI Ref ID J:82473]

Hodgin JB; Krege JH; Reddick RL; Korach KS; Smithies O; Maeda N. 2001. Estrogen receptor alpha is a major mediator of 17beta-estradiol's atheroprotective effects on lesion size in Apoe-/- mice. J Clin Invest 107(3):333-40. [PubMed: 11160157]  [MGI Ref ID J:68574]

Iafrati MD; Karas RH; Aronovitz M; Kim S; Sullivan TR Jr; Lubahn DB ; O'Donnell TF Jr ; Korach KS ; Mendelsohn ME. 1997. Estrogen inhibits the vascular injury response in estrogen receptor alpha-deficient mice. Nat Med 3(5):545-8. [PubMed: 9142124]  [MGI Ref ID J:40183]

Ishimaru N; Arakaki R; Omotehara F; Yamada K; Mishima K; Saito I; Hayashi Y. 2006. Novel role for RbAp48 in tissue-specific, estrogen deficiency-dependent apoptosis in the exocrine glands. Mol Cell Biol 26(8):2924-35. [PubMed: 16581768]  [MGI Ref ID J:107385]

Ishimaru N; Arakaki R; Watanabe M; Kobayashi M; Miyazaki K; Hayashi Y. 2003. Development of autoimmune exocrinopathy resembling Sjogren's syndrome in estrogen-deficient mice of healthy background. Am J Pathol 163(4):1481-90. [PubMed: 14507655]  [MGI Ref ID J:85800]

Islander U; Erlandsson MC; Chavoshi T; Jochems C; Moverare S; Nilsson S; Ohlsson C; Gustafsson JA; Carlsten H. 2005. Estren-mediated inhibition of T lymphopoiesis is estrogen receptor-independent whereas its suppression of T cell-mediated inflammation is estrogen receptor-dependent. Clin Exp Immunol 139(2):210-5. [PubMed: 15654819]  [MGI Ref ID J:95690]

Islander U; Erlandsson MC; Hasseus B; Jonsson CA; Ohlsson C; Gustafsson JA; Dahlgren U; Carlsten H. 2003. Influence of oestrogen receptor alpha and beta on the immune system in aged female mice. Immunology 110(1):149-57. [PubMed: 12941152]  [MGI Ref ID J:113638]

Jelinsky SA; Harris HA; Brown EL; Flanagan K; Zhang X; Tunkey C; Lai K; Lane MV; Simcoe DK; Evans MJ. 2003. Global transcription profiling of estrogen activity: estrogen receptor alpha regulates gene expression in the kidney. Endocrinology 144(2):701-10. [PubMed: 12538633]  [MGI Ref ID J:115555]

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Kurita T; Lee K; Saunders PT; Cooke PS; Taylor JA; Lubahn DB; Zhao C; Makela S; Gustafsson JA; Dahiya R; Cunha GR. 2001. Regulation of progesterone receptors and decidualization in uterine stroma of the estrogen receptor-alpha knockout mouse. Biol Reprod 64(1):272-83. [PubMed: 11133684]  [MGI Ref ID J:68452]

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Muller-Delp JM; Lubahn DB; Nichol KE; Philips BJ; Price EM; Curran EM; Laughlin MH. 2003. Regulation of nitric oxide-dependent vasodilation in coronary arteries of estrogen receptor-alpha-deficient mice. Am J Physiol Heart Circ Physiol 285(5):H2150-7. [PubMed: 12881205]  [MGI Ref ID J:108044]

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Paria BC; Tan J; Lubahn DB; Dey SK; Das SK. 1999. Uterine decidual response occurs in estrogen receptor-alpha-deficient mice. Endocrinology 140(6):2704-10. [PubMed: 10342861]  [MGI Ref ID J:55146]

Parikka V; Peng Z; Hentunen T; Risteli J; Elo T; Vaananen HK; Harkonen P. 2005. Estrogen responsiveness of bone formation in vitro and altered bone phenotype in aged estrogen receptor-alpha-deficient male and female mice. Eur J Endocrinol 152(2):301-14. [PubMed: 15745940]  [MGI Ref ID J:101970]

Pendaries C; Darblade B; Rochaix P; Krust A; Chambon P; Korach KS; Bayard F; Arnal JF. 2002. The AF-1 activation-function of ERalpha may be dispensable to mediate the effect of estradiol on endothelial NO production in mice. Proc Natl Acad Sci U S A 99(4):2205-10. [PubMed: 11854517]  [MGI Ref ID J:74683]

Polanczyk M; Yellayi S; Zamora A; Subramanian S; Tovey M; Vandenbark AA; Offner H; Zachary JF; Fillmore PD; Blankenhorn EP; Gustafsson JA; Teuscher C. 2004. Estrogen receptor-1 (Esr1) and -2 (Esr2) regulate the severity of clinical experimental allergic encephalomyelitis in male mice. Am J Pathol 164(6):1915-24. [PubMed: 15161628]  [MGI Ref ID J:91109]

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Risbridger G; Wang H; Young P; Kurita T; Wang YZ; Lubahn D; Gustafsson JA; Cunha G. 2001. Evidence that epithelial and mesenchymal estrogen receptor-alpha mediates effects of estrogen on prostatic epithelium. Dev Biol 229(2):432-42. [PubMed: 11150243]  [MGI Ref ID J:110625]

Risbridger GP; Wang H; Frydenberg M; Cunha G. 2001. The metaplastic effects of estrogen on mouse prostate epithelium: proliferation of cells with basal cell phenotype. Endocrinology 142(6):2443-50. [PubMed: 11356693]  [MGI Ref ID J:115615]

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Rosenfeld CS; Cooke PS; Welsh TH Jr; Simmer G; Hufford MG; Gustafsson JA; Hess RA; Lubahn DB. 2000. The differential fate of mesonephric tubular-derived efferent ductules in estrogen receptor-alpha knockout versus wild-type female mice. Endocrinology 141(10):3792-8. [PubMed: 11014235]  [MGI Ref ID J:108807]

Rosenfeld CS; Ganjam VK; Taylor JA; Yuan X; Stiehr JR; Hardy MP ; Lubahn DB. 1998. Transcription and translation of estrogen receptor-beta in the male reproductive tract of estrogen receptor-alpha knock-out and wild-type mice. Endocrinology 139(6):2982-7. [PubMed: 9607809]  [MGI Ref ID J:48220]

Rosenfeld CS; Murray AA; Simmer G; Hufford MG; Smith MF; Spears N; Lubahn DB. 2000. Gonadotropin induction of ovulation and corpus luteum formation in young estrogen receptor-alpha knockout mice. Biol Reprod 62(3):599-605. [PubMed: 10684800]  [MGI Ref ID J:108586]

Rubanyi GM; Freay AD; Kauser K; Sukovich D; Burton G; Lubahn DB; Couse JF; Curtis SW; Korach KS. 1997. Vascular estrogen receptors and endothelium-derived nitric oxide production in the mouse aorta. Gender difference and effect of estrogen receptor gene disruption. J Clin Invest 99(10):2429-37. [PubMed: 9153286]  [MGI Ref ID J:40474]

Ruz R; Gregory M; Smith CE; Cyr DG; Lubahn DB; Hess RA; Hermo L. 2006. Expression of aquaporins in the efferent ductules, sperm counts, and sperm motility in estrogen receptor-alpha deficient mice fed lab chow versus casein. Mol Reprod Dev 73(2):226-37. [PubMed: 16261609]  [MGI Ref ID J:104867]

Sato T; Matsumoto T; Kawano H; Watanabe T; Uematsu Y; Sekine K; Fukuda T; Aihara K; Krust A; Yamada T; Nakamichi Y; Yamamoto Y; Nakamura T; Yoshimura K; Yoshizawa T; Metzger D; Chambon P; Kato S. 2004. Brain masculinization requires androgen receptor function. Proc Natl Acad Sci U S A 101(6):1673-8. [PubMed: 14747651]  [MGI Ref ID J:88153]

Savolainen S; Santti R; Streng T; Gustafsson JA; Harkonen P; Makela S. 2005. Sex specific expression of progesterone receptor in mouse lower urinary tract. Mol Cell Endocrinol 230(1-2):17-21. [PubMed: 15664447]  [MGI Ref ID J:104822]

Schomberg DW; Couse JF; Mukherjee A; Lubahn DB; Sar M; Mayo KE; Korach KS. 1999. Targeted disruption of the estrogen receptor-alpha gene in female mice: characterization of ovarian responses and phenotype in the adult. Endocrinology 140(6):2733-44. [PubMed: 10342864]  [MGI Ref ID J:55147]

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Scully KM; Gleiberman AS; Lindzey J; Lubahn DB; Korach KS; Rosenfeld MG. 1997. Role of estrogen receptor-alpha in the anterior pituitary gland. Mol Endocrinol 11(6):674-81. [PubMed: 9171231]  [MGI Ref ID J:40607]

Shim GJ; Kis LL; Warner M; Gustafsson JA. 2004. Autoimmune glomerulonephritis with spontaneous formation of splenic germinal centers in mice lacking the estrogen receptor alpha gene. Proc Natl Acad Sci U S A 101(6):1720-4. [PubMed: 14745006]  [MGI Ref ID J:88156]

Shughrue PJ; Askew GR; Dellovade TL; Merchenthaler I. 2002. Estrogen-binding sites and their functional capacity in estrogen receptor double knockout mouse brain. Endocrinology 143(5):1643-50. [PubMed: 11956145]  [MGI Ref ID J:76322]

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Simerly RB; Zee MC; Pendleton JW; Lubahn DB; Korach KS. 1997. Estrogen receptor-dependent sexual differentiation of dopaminergic neurons in the preoptic region of the mouse. Proc Natl Acad Sci U S A 94(25):14077-82. [PubMed: 9391155]  [MGI Ref ID J:99716]

Singh M; Setalo G Jr; Guan X; Frail DE; Toran-Allerand CD. 2000. Estrogen-induced activation of the mitogen-activated protein kinase cascade in the cerebral cortex of estrogen receptor-alpha knock-out mice. J Neurosci 20(5):1694-700. [PubMed: 10684871]  [MGI Ref ID J:60587]

Siracusa MC; Overstreet MG; Housseau F; Scott AL; Klein SL. 2008. 17beta-estradiol alters the activity of conventional and IFN-producing killer dendritic cells. J Immunol 180(3):1423-31. [PubMed: 18209037]  [MGI Ref ID J:131352]

Skavdahl M; Steenbergen C; Clark J; Myers P; Demianenko T; Mao L; Rockman HA; Korach KS; Murphy E. 2005. Estrogen receptor-beta mediates male-female differences in the development of pressure overload hypertrophy. Am J Physiol Heart Circ Physiol 288(2):H469-76. [PubMed: 15374829]  [MGI Ref ID J:96155]

Smithson G; Couse JF; Lubahn DB; Korach KS; Kincade PW. 1998. The role of estrogen receptors and androgen receptors in sex steroid regulation of B lymphopoiesis. J Immunol 161(1):27-34. [PubMed: 9647203]  [MGI Ref ID J:110923]

Staples JE; Gasiewicz TA; Fiore NC; Lubahn DB; Korach KS; Silverstone AE. 1999. Estrogen receptor alpha is necessary in thymic development and estradiol-induced thymic alterations. J Immunol 163(8):4168-74. [PubMed: 10510352]  [MGI Ref ID J:111590]

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Svenson JL; EuDaly J; Ruiz P; Korach KS; Gilkeson GS. 2008. Impact of estrogen receptor deficiency on disease expression in the NZM2410 lupus prone mouse. Clin Immunol 128(2):259-68. [PubMed: 18514033]  [MGI Ref ID J:137724]

Tekmal RR; Liu YG; Nair HB; Jones J; Perla RP; Lubahn DB; Korach KS; Kirma N. 2005. Estrogen receptor alpha is required for mammary development and the induction of mammary hyperplasia and epigenetic alterations in the aromatase transgenic mice. J Steroid Biochem Mol Biol 95(1-5):9-15. [PubMed: 15955696]  [MGI Ref ID J:100292]

Thurmond TS; Murante FG; Staples JE; Silverstone AE; Korach KS; Gasiewicz TA. 2000. Role of estrogen receptor alpha in hematopoietic stem cell development and B lymphocyte maturation in the male mouse. Endocrinology 141(7):2309-18. [PubMed: 10875230]  [MGI Ref ID J:63462]

Tomihara K; Kaitsuka T; Soga T; Korach KS; Pfaff DW; Takahama K; Ogawa S. 2006. Abolition of sex-dependent effects of prenatal exposure to diethylstilbestrol on emotional behavior in estrogen receptor-alpha knockout mice. Neuroreport 17(11):1169-73. [PubMed: 16837848]  [MGI Ref ID J:111819]

Ullrich ND; Krust A; Collins P; MacLeod KT. 2008. Genomic deletion of estrogen receptors ERalpha and ERbeta does not alter estrogen-mediated inhibition of Ca2+ influx and contraction in murine cardiomyocytes. Am J Physiol Heart Circ Physiol 294(6):H2421-7. [PubMed: 18441199]  [MGI Ref ID J:136662]

Umetani M; Domoto H; Gormley AK; Yuhanna IS; Cummins CL; Javitt NB; Korach KS; Shaul PW; Mangelsdorf DJ. 2007. 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen. Nat Med 13(10):1185-92. [PubMed: 17873880]  [MGI Ref ID J:129931]

Van Cromphaut SJ; Rummens K; Stockmans I; Van Herck E; Dijcks FA; Ederveen AG; Carmeliet P; Verhaeghe J; Bouillon R; Carmeliet G. 2003. Intestinal calcium transporter genes are upregulated by estrogens and the reproductive cycle through vitamin D receptor-independent mechanisms. J Bone Miner Res 18(10):1725-36. [PubMed: 14584880]  [MGI Ref ID J:111515]

Vandenput L; Ederveen AG; Erben RG; Stahr K; Swinnen JV; Van Herck E; Verstuyf A; Boonen S; Bouillon R; Vanderschueren D. 2001. Testosterone prevents orchidectomy-induced bone loss in estrogen receptor-alpha knockout mice. Biochem Biophys Res Commun 285(1):70-6. [PubMed: 11437374]  [MGI Ref ID J:70361]

Vidal O; Lindberg M; Savendahl L; Lubahn DB; Ritzen EM; Gustafsson JA; Ohlsson C. 1999. Disproportional body growth in female estrogen receptor-alpha-inactivated mice. Biochem Biophys Res Commun 265(2):569-71. [PubMed: 10558910]  [MGI Ref ID J:114164]

Vidal O; Lindberg MK; Hollberg K; Baylink DJ; Andersson G; Lubahn DB; Mohan S; Gustafsson JA; Ohlsson C. 2000. Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice. Proc Natl Acad Sci U S A 97(10):5474-9. [PubMed: 10805804]  [MGI Ref ID J:62222]

Villablanca A; Lubahn D; Shelby L; Lloyd K; Barthold S. 2004. Susceptibility to early atherosclerosis in male mice is mediated by estrogen receptor alpha. Arterioscler Thromb Vasc Biol 24(6):1055-61. [PubMed: 15117737]  [MGI Ref ID J:102338]

Wang C; Dehghani B; Magrisso IJ; Rick EA; Bonhomme E; Cody DB; Elenich LA; Subramanian S; Murphy SJ; Kelly MJ; Rosenbaum JS; Vandenbark AA; Offner H. 2008. GPR30 Contributes to Estrogen-Induced Thymic Atrophy. Mol Endocrinol 22(3):636-48. [PubMed: 18063692]  [MGI Ref ID J:131313]

Wang M; Crisostomo P; Wairiuko GM; Meldrum DR. 2006. Estrogen receptor-alpha mediates acute myocardial protection in females. Am J Physiol Heart Circ Physiol 290(6):H2204-9. [PubMed: 16415070]  [MGI Ref ID J:111852]

Watanabe H; Suzuki A; Mizutani T; Khono S; Lubahn DB; Handa H; Iguchi T. 2002. Genome-wide analysis of changes in early gene expression induced by oestrogen. Genes Cells 7(5):497-507. [PubMed: 12047351]  [MGI Ref ID J:80265]

Wersinger SR; Haisenleder DJ; Lubahn DB; Rissman EF. 1999. Steroid feedback on gonadotropin release and pituitary gonadotropin subunit mRNA in mice lacking a functional estrogen receptor alpha Endocrine 11(2):137-43. [PubMed: 10709760]  [MGI Ref ID J:61298]

Wersinger SR; Rissman EF. 2000. Dopamine activates masculine sexual behavior independent of the estrogen receptor alpha. J Neurosci 20(11):4248-54. [PubMed: 10818161]  [MGI Ref ID J:62233]

Wersinger SR; Rissman EF. 2000. Neuroendocrinology briefings: oestrogen receptor alpha is essential for female-directed chemo-investigatory behaviour but is not required for the pheromone-induced luteinizing hormone surge in male mice J Neuroendocrinol 12(2):103-10. [PubMed: 10718905]  [MGI Ref ID J:61264]

Wintermantel TM; Campbell RE; Porteous R; Bock D; Grone HJ; Todman MG; Korach KS; Greiner E; Perez CA; Schutz G; Herbison AE. 2006. Definition of estrogen receptor pathway critical for estrogen positive feedback to gonadotropin-releasing hormone neurons and fertility. Neuron 52(2):271-80. [PubMed: 17046690]  [MGI Ref ID J:117231]

Xue B; Pamidimukkala J; Lubahn DB; Hay M. 2007. Estrogen receptor-alpha mediates estrogen protection from angiotensin II-induced hypertension in conscious female mice. Am J Physiol Heart Circ Physiol 292(4):H1770-6. [PubMed: 17142339]  [MGI Ref ID J:125828]

Yamamoto Y; Moore R; Hess HA; Guo GL; Gonzalez FJ; Korach KS; Maronpot RR; Negishi M. 2006. Estrogen receptor alpha mediates 17alpha-ethynylestradiol causing hepatotoxicity. J Biol Chem 281(24):16625-31. [PubMed: 16606610]  [MGI Ref ID J:113721]

Yin Y; Huang WW; Lin C; Chen H; Mackenzie A; Ma L. 2008. Estrogen suppresses uterine epithelial apoptosis by inducing birc1 expression. Mol Endocrinol 22(1):113-25. [PubMed: 17901126]  [MGI Ref ID J:130045]

Yue W; Santen RJ; Wang JP; Li Y; Verderame MF; Bocchinfuso WP; Korach KS; Devanesan P; Todorovic R; Rogan EG; Cavalieri EL. 2003. Genotoxic metabolites of estradiol in breast: potential mechanism of estradiol induced carcinogenesis. J Steroid Biochem Mol Biol 86(3-5):477-86. [PubMed: 14623547]  [MGI Ref ID J:86738]

Zhai P; Eurell TE; Cooke PS; Lubahn DB; Gross DR. 2000. Myocardial ischemia-reperfusion injury in estrogen receptor-alpha knockout and wild-type mice. Am J Physiol Heart Circ Physiol 278(5):H1640-7. [PubMed: 10775144]  [MGI Ref ID J:62353]

Zhou Q; Clarke L; Nie R; Carnes K; Lai LW; Lien YH; Verkman A; Lubahn D; Fisher JS; Katzenellenbogen BS; Hess RA. 2001. Estrogen action and male fertility: roles of the sodium/hydrogen exchanger-3 and fluid reabsorption in reproductive tract function. Proc Natl Acad Sci U S A 98(24):14132-7. [PubMed: 11698654]  [MGI Ref ID J:125658]

Zoubina EV; Smith PG. 2001. Sympathetic hyperinnervation of the uterus in the estrogen receptor alpha knock-out mouse. Neuroscience 103(1):237-44. [PubMed: 11311804]  [MGI Ref ID J:85911]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX12

Colony Maintenance

Breeding & HusbandryThis strain originated on a B6;129P2 background and has been backcrossed to C57BL/6 for ten generations. The colony is maintained by mating heterozygous carrier mice. Expected coat color is: Black
Diet Information LabDiet® 5K52/5K67

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations             View   International   Pricing
Weeks of AgePrice*GenderGenotypes Provided
Individual Mouse Price $236.40Female or MaleHeterozygous for Esr1tm1Ksk
$291.90Female or MaleHomozygous for Esr1tm1Ksk
Pairs /Price*Pair Genotype
$472.80Heterozygous for Esr1tm1Ksk x Heterozygous for Esr1tm1Ksk
*Price(s) in US dollars ($)

Supply Details

Standard SupplyRepository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.
Supply Notes

Pricing for International shipping destinations             View   USA, Canada and Mexico   Pricing
Weeks of AgePrice*GenderGenotypes Provided
Individual Mouse Price $307.40Female or MaleHeterozygous for Esr1tm1Ksk
$379.50Female or MaleHomozygous for Esr1tm1Ksk
Pairs /Price*Pair Genotype
$614.70Heterozygous for Esr1tm1Ksk x Heterozygous for Esr1tm1Ksk
*Price(s) in US dollars ($)

Supply Details

Standard SupplyRepository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.
Supply Notes

Control Information

  Allele   Control
 Esr1tm1Ksk  Wild-type from the colony
 
  Considerations for Choosing Controls
  USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
  International - Control Pricing Information for Genetically Engineered Mutant Strains.

General Terms and Conditions

View JAX® Mice & Services Conditions of Use.

For additional Licensing and Use Restrictions view the link(s) below:
- Notice Regarding cre/Esr1 (Tamoxifen Inducible Cre) Strains.
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering and Purchasing Information

      Purchasing Information
      JAX® Mice Orders
      Surgical Services

Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form


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