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Strain Name:

C57BL/6J-Pde6brd1-2J/J

Stock Number:

004766

Availability:

Repository- Live

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General Terms and Conditions

Former Name      C57BL/6J-Pde6b2J/J    (Changed: 07-AUG-07 )
      C57BL/6J-Pde6bnmf137    (Changed: 15-DEC-04 )
      C57BL/6J-Pde6bnmf137/J    (Changed: 15-DEC-04 )
      NMF137    (Changed: 15-DEC-04 )
Genes & Alleles   Pde6b;   Pde6brd1-2J;

Product Information

Strain Details

Type JAX® GEMM® Strain - Chemically Induced Mutation
Additional information on JAX® GEMM® Strains.
Type JAX® GEMM® Strain - Coisogenic
Type JAX® GEMM® Strain - Mutant Strain
Specieslaboratory mouse
H2 Haplotypeb

Appearance
black
Related Genotype: a/a

Strain Description
View strain phenotype and additional information on the Neuroscience Mutagenesis Facility web page for Pde6b2J entry.

Related Disease (OMIM) Terms

Night Blindness, Congenital Stationary, Autosomal Dominant 2; CSNBAD2
Mammalian Phenotype Terms assigned by genotype

Pde6brd1-2J/Pde6brd1-2J

        C57BL/6J-Pde6brd1-2J/J
  • vision/eye phenotype
  • abnormal eye electrophysiology (MGI Ref ID J:122722)
    • electroretinogram recordings reveal that homozygotes show no detectable rod or cone responses at any age
  • abnormal retinal vasculature (MGI Ref ID J:122722)
    • white retinal vessels are clinically observed at 24 days of age
  • retinal degeneration (MGI Ref ID J:122722)
    • indirect opthalmoscopic examination reveals a mottled retina by 24 days of age, indicative of retinal degeneration
    • histological analysis demonstrates extensive degeneration of the outer nuclear layer of the retina by 16 days of age and no outer nuclear layer remaining by 30 days of age
  • cardiovascular system phenotype
  • abnormal retinal vasculature (MGI Ref ID J:122722)
    • white retinal vessels are clinically observed at 24 days of age

Gene & Allele Details

Allele Symbol Pde6brd1-2J
Allele Name retinal degeneration 1, 2 Jackson
Common Name(s) NMF137; Pde6b2J; Pde6bnmf137; neuroscience mutagenesis facility, 137;
Strain of OriginC57BL/6J
Gene Symbol and Name Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
Chromosome 5
Gene Common Name(s) CSNB3; PDEB; Pdeb; RP40; nmf137; phosphodiesterase, cGMP, rod receptor, beta polypeptide; r; rd; rd-1; rd1; rd10; retinal degeneration; retinal degeneration 1; retinal degeneration 10;
Molecular Note This mutation was shown by genetic complementation analysis to be an allele of Pde6b. Molecular sequence analysis showed that this mutation corresponds to a point mutation in exon 16. [MGI Ref ID J:122722]

Control Information

  Allele   Control
 Pde6brd1-2J  000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Pde6b
004202   B6.C3 Pde6brd1 Hps4le/+ +-Lmx1adr-8J/J
000002   B6.C3-Pde6brd1 Hps4le/J
004297   B6.CXB1-Pde6brd10/J
001022   B6C3FeF1/J a/a
000652   BDP/J
000653   BUB/BnJ
002439   C3.129P2(B6)-B2mtm1Unc/J
005494   C3.129S1(B6)-Grm1rcw/J
002802   C3.BLiA Pde6b+-Krd/J
000480   C3.MRL-Faslpr/J
001957   C3A Pde6brd1.O20/A-Prph2Rd2/J
001979   C3A.BLiA-Pde6b+.O20-Prph2Rd2/J
001912   C3A.BLiA-Pde6b+/J
005973   C3Bir.129P2(B6)-Il10C3Bir/LtJ
004326   C3Bir.129P2(B6)-Il10tm1Cgn/Lt
003968   C3Bir.129P2(B6)-Il10tm1Cgn/LtJ
001906   C3Ga.Cg-Catb/J
001904   C3H-Atcayji-hes/J
000659   C3H/HeJ
000784   C3H/HeJ-Faslgld/J
000509   C3H/HeJ-Lystbg-2J/J
002433   C3H/HeJ-Spnb4qv-lnd2J/J
005972   C3H/HeJBirLtJ
001824   C3H/HeJSxJ
000635   C3H/HeOuJ
000474   C3H/HeSn
001431   C3H/HeSn-ocd/J
000661   C3H/HeSnJ
002235   C3H/HeSnJ-Ctnna2cdf/J
002333   C3H/HeSnJ-gri/J
006435   C3HeB.SW-Soaa/MonJ
000658   C3HeB/FeJ
001576   C3HeB/FeJ-Atp7btx-J/J
002588   C3HeB/FeJ-Eya1bor/J
001533   C3HeB/FeJ-Mc1rE-so Gli3Xt-J/J
001886   C3HeB/FeJLe a/a-gnd/J
001908   C3HfB/BiJ
001502   C3Sn.B6-Epha4rb/J
003648   C3Sn.BLiA-Pde6b+/Dn
001547   C3Sn.Cg-Cm/J
000656   CBA/J
000813   CBA/J-Atp7aMo-pew/J
000660   DA/HuSnJ
000023   FL/1ReJ
000025   FL/4ReJ
003078   FVB-Tg(WapIgf1)39Dlr/J
003024   FVB.129P2(B6)-Fmr1tm1Cgr/J
002539   FVB.129P2-Abcb4tm1Bor/J
004828   FVB.129P2-Pde6b+ Tyrc-ch/AntJ
002935   FVB.129S2(B6)-Ccnd1tm1Wbg/J
002953   FVB.Cg-Tg(MMTVTGFA)254Rjc/J
003170   FVB.Cg-Tg(Myh6-tTA)6Smbf/J
003257   FVB/N-Tg(GFAPGFP)14Mes/J
002374   FVB/N-Tg(MMTV-PyVT)634Mul/J
002856   FVB/N-Tg(TIE2-lacZ)182Sato/J
002384   FVB/N-Tg(UcpDta)1Kz/J
001800   FVB/NJ
003487   FVB/NJ-Tg(XGFAP-lacZ)3Mes/J
001491   FVB/NMob
000734   MOLD/RkJ
000550   MOLF/EiJ
002423   NON/ShiLtJ
000679   P/J
000680   PL/J
100299   PLSJLF1/J
000269   SB/LeJ
005651   SJL.AK-Thy1a/TseJ
000686   SJL/J
000688   ST/bJ
004808   STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
002648   STOCK a/a Cln6nclf/J
000279   STOCK gr +/+ Ap3d1mh/J
005965   STOCK Tg(Pomc1-cre)16Lowl/J
004770   SW.B6-Soab/J
002023   SWR.M-Emv21 Emv22/J
000689   SWR/J
000939   SWR/J-Clcn1adr-mto/J
000692   WB/ReJ KitW/J
100410   WBB6F1/J-KitW/KitW-v/J
000693   WC/ReJ KitlSl/J
100401   WCB6F1/J KitlSl KitlSl-d
View Strains carrying other alleles of Pde6b     (81 strains)

Animal Health Reports

Room Number           A1

Research Applications

This mouse can be used to support research in many areas including:

Pde6brd1-2J related

Mouse/Human Gene Homologs
retinitis pigmentosa, autosomal recessive

Neurobiology Research
Neuroscience Mutagenesis Facility Strain

Sensorineural Research
Retinal Degeneration

References

Additional References

Price and Supply Information

Strain Name: C57BL/6J-Pde6brd1-2J/J
Stock Number: 004766

Price Details

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Supply Details

Standard SupplyRepository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.
Supply Notes Usually shipped between four and eight weeks of age.
This strain is included in the Eye Mutant Resource within the Mouse Mutant Resource collection.
LicensingSee General Terms and Conditions below  
Control InformationView Control Information in Strain Details.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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